Harvard Catalyst Profiles

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Mark W. Feinberg, M.D.

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Mentoring
Available: 10/01/18, Expires: 12/31/21

The laboratory's focus is understanding non-coding RNAs (microRNAs and lncRNAs) in cardiovascular disease states including atherosclerosis, insulin resistance/obesity, post-MI repair, and diabetic wound healing. For this specific project, we have screened and identified novel non-coding RNAs (lncRNAs) from the vascular endothelium of atherosclerotic mice. We seek motivated individuals who will help examine the functional and mechanistic role of 1 of these lncRNAs in established experimental models of vascular disease and in endothelial cells in culture.

Available: 06/01/20, Expires: 06/01/22

W

We have several research projects involving either microRNAs or lncRNAs identified in specific cell types important in cardiovascular diseases such as atherosclerosis, myocardial infarction, ischemia. Studies are examining these non-coding RNAs from mice to human samples and focus on evolutionarily conserved ncRNAs and their targets.

Related projects available involve expression, functional, and mechanistic studies of such factors in a given cell type such as monocyte/macrophages, T cells (T regulatory cells), or endothelial cells. For microRNAs identified, validation studies would also include using available databases and bioinformatics to verify gene targets and binding to 3’-UTR regions. For lncRNAs, both cis and trans-regulated mechanisms are pursued. Key observations will be validated using functional assays in mouse models of vascular disease. The projects would be a great opportunity for a medical student for 3-12 months and would provide a framework for acquiring knowledge and skills of RNA-Seq/miRNA-Seq biology, molecular & cell biology, functional assays (ie. cell adhesion, migration, differentiation, others), and/or analyses of diseased mice depending upon the project. The setting would include laboratory meetings at the Center for Excellence in Vascular Biology at the New Research Building (NRB/ Harvard Institutes of Medicine) as well as weekly divisional meetings. These projects are in various levels of maturity and I would be happy to discuss them to any HMS/HSDM students interested in learning more.

The Role of MicroRNAs in Vascular Transdifferentiation and Re-Endothelialization
Summer, 01/02/13 - 02/09/14
The role of statins in regulatory T cell formation and function
Summer, 05/30/07 - 08/31/07
The Role of MicroRNAs in Vascular Endothelial Cells Inflammation
Summer, 06/16/08 - 08/01/08
Role of MicroRNA-181b in Regulating Hydrogen Peroxide Signaling in Endothelial Cells
Summer, 06/01/15 - 01/01/16
Effect of MicroRNAs on KLF10-mediated Control of T Regulatory Cell Differentiation and Function
Spanish, 06/14/11 - 08/10/11

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL153356 (FEINBERG, MARK W) Jul 15, 2020 - Jun 30, 2024
    NIH
    LncRNA MAARS, macrophage apoptosis, and atherosclerosis
    Role: Principal Investigator
  2. R01HL148207 (FEINBERG, MARK W) May 15, 2020 - Apr 30, 2024
    NIH
    miR-615, AKT/eNOS signaling, and angiogenesis
    Role: Principal Investigator
  3. R01HL148355 (FEINBERG, MARK W) May 15, 2020 - Apr 30, 2024
    NIH
    LncRNA SNHG12, vascular senescence, and atherosclerosis
    Role: Principal Investigator
  4. R01HL134849 (FEINBERG, MARK W) Dec 15, 2016 - Nov 30, 2020
    NIH
    KLF10, CD4+ T cells, and transplant arteriopathy
    Role: Principal Investigator
  5. R01GM115605 (FEINBERG, MARK W) Aug 15, 2015 - May 31, 2019
    NIH
    MicroRNA-181b and Sepsis
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Becker-Greene D, Li H, Perez-Cremades D, Wu W, Bestepe F, Ozdemir D, Niosi CE, Aydogan C, Orgill DP, Feinberg MW, Icli B. MiR-409-3p targets a MAP4K3-ZEB1-PLGF signaling axis and controls brown adipose tissue angiogenesis and insulin resistance. Cell Mol Life Sci. 2021 Oct 26. PMID: 34698882.
    Citations:    Fields:    
  2. Ni H, Haemmig S, Deng Y, Chen J, Simion V, Yang D, Sukhova G, Shvartz E, Wara AKMK, Cheng HS, Pérez-Cremades D, Assa C, Sausen G, Zhuang R, Dai Q, Feinberg MW. A Smooth Muscle Cell-Enriched Long Noncoding RNA Regulates Cell Plasticity and Atherosclerosis by Interacting With Serum Response Factor. Arterioscler Thromb Vasc Biol. 2021 09; 41(9):2399-2416. PMID: 34289702.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Nguyen THP, Fagerland MW, Deyab G, Hjeltnes G, Hollan I, Feinberg MW, Eilertsen GØ, Mikkelsen K, Agewall S. Antirheumatic therapy is not associated with changes in circulating N-terminal pro-brain natriuretic peptide levels in patients with autoimmune arthritis. PLoS One. 2021; 16(6):e0253793. PMID: 34170978.
    Citations:    Fields:    
  4. Sun X, Feinberg MW. Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities. Front Physiol. 2021; 12:693067. PMID: 34220553.
    Citations:    
  5. Newman JD, Cornwell MG, Zhou H, Rockman C, Heguy A, Suarez Y, Cheng HS, Feinberg MW, Hochman JS, Ruggles KV, Berger JS. Gene Expression Signature in Patients With Symptomatic Peripheral Artery Disease. Arterioscler Thromb Vasc Biol. 2021 04; 41(4):1521-1533. PMID: 33657880.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Xu X, Shi Y, Luan P, Kou W, Li B, Zhai M, You S, Yu Q, Zhuang J, Jian W, Feinberg MW, Peng W. The subcellular redistribution of NLRC5 promotes angiogenesis via interacting with STAT3 in endothelial cells. Theranostics. 2021; 11(9):4483-4501. PMID: 33754073.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Cai Y, Zhang Y, Chen H, Sun XH, Zhang P, Zhang L, Liao MY, Zhang F, Xia ZY, Man RY, Feinberg MW, Leung SW. MicroRNA-17-3p suppresses NF-?B-mediated endothelial inflammation by targeting NIK and IKKß binding protein. Acta Pharmacol Sin. 2021 Feb 23. PMID: 33623121.
    Citations: 1     Fields:    
  8. Haemmig S, Hashemi Gheinani A, Zaromytidou M, Siasos G, Coskun AU, Cormier MA, Gross DA, Wara AKMK, Antoniadis AP, Sun X, Sukhova GK, Welt FGP, Andreou I, Whatling C, Gan LM, Wikström J, Edelman ER, Libby P, Stone PH, Feinberg MW. Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans. Arterioscler Thromb Vasc Biol. 2021 04; 41(4):1487-1503. PMID: 33567868.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  9. Cheng X, Shihabudeen Haider Ali MS, Moran M, Viana MP, Schlichte SL, Zimmerman MC, Khalimonchuk O, Feinberg MW, Sun X. Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity. Redox Biol. 2021 04; 40:101863. PMID: 33508742.
    Citations: 3     Fields:    Translation:HumansCells
  10. Yang D, Haemmig S, Zhou H, Pérez-Cremades D, Sun X, Chen L, Li J, Haneo-Mejia J, Yang T, Hollan I, Feinberg MW. Methotrexate attenuates vascular inflammation through an adenosine-microRNA-dependent pathway. Elife. 2021 Jan 08; 10. PMID: 33416495.
    Citations: 2     Fields:    
  11. Wara AK, Wang S, Wu C, Fang F, Haemmig S, Weber BN, Aydogan CO, Tesmenitsky Y, Aliakbarian H, Hawse JR, Subramaniam M, Zhao L, Sage PT, Tavakkoli A, Garza A, Lynch L, Banks AS, Feinberg MW. KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver. Cell Rep. 2020 12 29; 33(13):108550. PMID: 33378664.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Pérez-Cremades D, Cheng HS, Feinberg MW. Revisiting Hormonal Control of Vascular Injury and Repair. Circ Res. 2020 12 04; 127(12):1488-1490. PMID: 33270545.
    Citations:    Fields:    Translation:HumansCells
  13. Simion V, Zhou H, Haemmig S, Pierce JB, Mendes S, Tesmenitsky Y, Pérez-Cremades D, Lee JF, Chen AF, Ronda N, Papotti B, Marto JA, Feinberg MW. A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus. Nat Commun. 2020 12 01; 11(1):6135. PMID: 33262333.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  14. Pierce JB, Simion V, Icli B, Pérez-Cremades D, Cheng HS, Feinberg MW. Computational Analysis of Targeting SARS-CoV-2, Viral Entry Proteins ACE2 and TMPRSS2, and Interferon Genes by Host MicroRNAs. Genes (Basel). 2020 11 16; 11(11). PMID: 33207533.
    Citations: 11     Fields:    Translation:HumansCells
  15. Zhou H, Simion V, Pierce JB, Haemmig S, Chen AF, Feinberg MW. LncRNA-MAP3K4 regulates vascular inflammation through the p38 MAPK signaling pathway and cis-modulation of MAP3K4. FASEB J. 2021 01; 35(1):e21133. PMID: 33184917.
    Citations:    Fields:    Translation:AnimalsCells
  16. Simion V, Zhou H, Pierce JB, Yang D, Haemmig S, Tesmenitsky Y, Sukhova G, Stone PH, Libby P, Feinberg MW. LncRNA VINAS regulates atherosclerosis by modulating NF-?B and MAPK signaling. JCI Insight. 2020 11 05; 5(21). PMID: 33021969.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  17. Feinberg MW. Editorial: The Role of Oxidative Stress, Epigenetics and Non-coding RNA in Regulating Trained Immunity. Front Immunol. 2020; 11:2114. PMID: 33013891.
    Citations:    Fields:    Translation:HumansAnimals
  18. Parmer C, De Sousa-Coelho AL, Cheng HS, Daher G, Burkart A, Dreyfuss JM, Pan H, Prenner JC, Keilson JM, Pande R, Henkin S, Feinberg MW, Patti ME, Creager MA. Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease. Vasc Med. 2020 10; 25(5):401-410. PMID: 32853041.
    Citations:    Fields:    Translation:HumansAnimals
  19. Zhuang R, Feinberg MW. Regulatory T cells in ischemic cardiovascular injury and repair. J Mol Cell Cardiol. 2020 10; 147:1-11. PMID: 32777294.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  20. Pierce JB, Feinberg MW. Long Noncoding RNAs in Atherosclerosis and Vascular Injury: Pathobiology, Biomarkers, and Targets for Therapy. Arterioscler Thromb Vasc Biol. 2020 09; 40(9):2002-2017. PMID: 32698685.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  21. Haemmig S, Yang D, Sun X, Das D, Ghaffari S, Molinaro R, Chen L, Deng Y, Freeman D, Moullan N, Tesmenitsky Y, Wara AKMK, Simion V, Shvartz E, Lee JF, Yang T, Sukova G, Marto JA, Stone PH, Lee WL, Auwerx J, Libby P, Feinberg MW. Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence. Sci Transl Med. 2020 02 19; 12(531). PMID: 32075942.
    Citations: 18     Fields:    Translation:HumansAnimals
  22. Barnett JV, Beckman JA, Bonaca MP, Carnethon MR, Cassis LA, Creager MA, Daugherty A, Feinberg MW, Freiberg MS, Goodney PP, Greenland P, Leeuwenburgh C, LeMaire SA, McDermott MM, Sabatine MS, Shen YH, Wasserman DH, Webb NR, Wells QS. American Heart Association Vascular Disease Strategically Focused Research Network. Arterioscler Thromb Vasc Biol. 2020 03; 40(3):e47-e54. PMID: 31969016.
    Citations:    Fields:    Translation:HumansAnimals
  23. Icli B, Li H, Pérez-Cremades D, Wu W, Ozdemir D, Haemmig S, Guimaraes RB, Manica A, Marchini JF, Orgill DP, Feinberg MW. MiR-4674 regulates angiogenesis in tissue injury by targeting p38K signaling in endothelial cells. Am J Physiol Cell Physiol. 2020 03 01; 318(3):C524-C535. PMID: 31913696.
    Citations: 1     Fields:    Translation:HumansCells
  24. Pérez-Cremades D, Cheng HS, Feinberg MW. Noncoding RNAs in Critical Limb Ischemia. Arterioscler Thromb Vasc Biol. 2020 03; 40(3):523-533. PMID: 31893949.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  25. Pierce JB, Feinberg MW. Editorial commentary: MicroRNAs as effectors and indicators of aspirin therapeutic potential. Trends Cardiovasc Med. 2020 07; 30(5):255-256. PMID: 31547951.
    Citations:    Fields:    Translation:Humans
  26. Luan P, Jian W, Xu X, Kou W, Yu Q, Hu H, Li D, Wang W, Feinberg MW, Zhuang J, Xu Y, Peng W. NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPAR?. Nat Commun. 2019 06 28; 10(1):2882. PMID: 31253783.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  27. Icli B, Wu W, Ozdemir D, Li H, Cheng HS, Haemmig S, Liu X, Giatsidis G, Avci SN, Lee N, Guimaraes RB, Manica A, Marchini JF, Rynning SE, Risnes I, Hollan I, Croce K, Yang X, Orgill DP, Feinberg MW. MicroRNA-615-5p Regulates Angiogenesis and Tissue Repair by Targeting AKT/eNOS (Protein Kinase B/Endothelial Nitric Oxide Synthase) Signaling in Endothelial Cells. Arterioscler Thromb Vasc Biol. 2019 07; 39(7):1458-1474. PMID: 31092013.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  28. Shihabudeen Haider Ali MS, Cheng X, Moran M, Haemmig S, Naldrett MJ, Alvarez S, Feinberg MW, Sun X. LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Nucleic Acids Res. 2019 02 20; 47(3):1505-1522. PMID: 30476192.
    Citations: 19     Fields:    Translation:HumansCells
  29. Icli B, Wu W, Ozdemir D, Li H, Haemmig S, Liu X, Giatsidis G, Cheng HS, Avci SN, Kurt M, Lee N, Guimaraes RB, Manica A, Marchini JF, Rynning SE, Risnes I, Hollan I, Croce K, Orgill DP, Feinberg MW. MicroRNA-135a-3p regulates angiogenesis and tissue repair by targeting p38 signaling in endothelial cells. FASEB J. 2019 04; 33(4):5599-5614. PMID: 30668922.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  30. Ozdemir D, Feinberg MW. MicroRNAs in diabetic wound healing: Pathophysiology and therapeutic opportunities. Trends Cardiovasc Med. 2019 04; 29(3):131-137. PMID: 30143275.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  31. Haemmig S, Simion V, Feinberg MW. Long Non-Coding RNAs in Vascular Inflammation. Front Cardiovasc Med. 2018; 5:22. PMID: 29662883.
    Citations: 11     
  32. Simion V, Haemmig S, Feinberg MW. LncRNAs in vascular biology and disease. Vascul Pharmacol. 2019 03; 114:145-156. PMID: 29425892.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  33. Haemmig S, Simion V, Yang D, Deng Y, Feinberg MW. Long noncoding RNAs in cardiovascular disease, diagnosis, and therapy. Curr Opin Cardiol. 2017 11; 32(6):776-783. PMID: 28786864.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  34. Kennedy SB, Bolay F, Kieh M, Grandits G, Badio M, Ballou R, Eckes R, Feinberg M, Follmann D, Grund B, Gupta S, Hensley L, Higgs E, Janosko K, Johnson M, Kateh F, Logue J, Marchand J, Monath T, Nason M, Nyenswah T, Roman F, Stavale E, Wolfson J, Neaton JD, Lane HC. Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia. N Engl J Med. 2017 10 12; 377(15):1438-1447. PMID: 29020589.
    Citations: 69     Fields:    Translation:HumansAnimalsCellsPHPublic HealthCTClinical Trials
  35. Feinberg MW. Editorial commentary: Let it snow-Emerging roles for snoRNAs in cardiovascular disease. Trends Cardiovasc Med. 2018 02; 28(2):91-93. PMID: 28882366.
    Citations:    Fields:    Translation:Humans
  36. Icli B, Feinberg MW. MicroRNAs in dysfunctional adipose tissue: cardiovascular implications. Cardiovasc Res. 2017 Jul 01; 113(9):1024-1034. PMID: 28505257.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  37. Zhang Y, Sun X, Icli B, Feinberg MW. Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy. Endocr Rev. 2017 04 01; 38(2):145-168. PMID: 28323921.
    Citations: 41     Fields:    Translation:Humans
  38. Zhang Y, Sun X, Icli B, Feinberg MW. Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy. Endocr Rev. 2017 Apr 01; 2017(1):1-22. PMID: 28520942.
    Citations:    
  39. Haemmig S, Feinberg MW. Targeting LncRNAs in Cardiovascular Disease: Options and Expeditions. Circ Res. 2017 02 17; 120(4):620-623. PMID: 28209793.
    Citations: 13     Fields:    Translation:Humans
  40. Haemmig S, Feinberg MW. MicroRNAs as Harbingers of High-Risk Carotid Artery Atherosclerotic Disease? Circ Res. 2017 02 17; 120(4):596-598. PMID: 28209785.
    Citations: 1     Fields:    Translation:Humans
  41. Røttingen JA, Gouglas D, Feinberg M, Plotkin S, Raghavan KV, Witty A, Draghia-Akli R, Stoffels P, Piot P. New Vaccines against Epidemic Infectious Diseases. N Engl J Med. 2017 Feb 16; 376(7):610-613. PMID: 28099066.
    Citations: 20     Fields:    Translation:HumansPHPublic Health
  42. Feinberg MW. No small task: therapeutic targeting of Lp(a) for cardiovascular disease. Lancet. 2016 Nov 05; 388(10057):2211-2212. PMID: 27665227.
    Citations: 2     Fields:    Translation:Humans
  43. Icli B, Feinberg MW. Plasticity of Arterial and Venous Endothelial Cell Identity: Some Nerve! Circ Res. 2016 08 19; 119(5):574-6. PMID: 27539966.
    Citations: 2     Fields:    Translation:Cells
  44. Lin J, He S, Sun X, Franck G, Deng Y, Yang D, Haemmig S, Wara AK, Icli B, Li D, Feinberg MW. MicroRNA-181b inhibits thrombin-mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10. FASEB J. 2016 09; 30(9):3216-26. PMID: 27297585.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  45. Benson MD, Lapedis CJ, Adler DS, Feinberg MW, Bhatt DL. Bulging at the Root: An Inflammatory Tale. Circulation. 2016 May 17; 133(20):1969-77. PMID: 27185024.
    Citations: 1     Fields:    Translation:Humans
  46. Feinberg MW, Moore KJ. MicroRNA Regulation of Atherosclerosis. Circ Res. 2016 Feb 19; 118(4):703-20. PMID: 26892968.
    Citations: 158     Fields:    Translation:HumansAnimalsCells
  47. Icli B, Nabzdyk CS, Lujan-Hernandez J, Cahill M, Auster ME, Wara AK, Sun X, Ozdemir D, Giatsidis G, Orgill DP, Feinberg MW. Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a. J Mol Cell Cardiol. 2016 Feb; 91:151-9. PMID: 26776318.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  48. Sun X, Lin J, Zhang Y, Kang S, Belkin N, Wara AK, Icli B, Hamburg NM, Li D, Feinberg MW. MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue. Circ Res. 2016 Mar 04; 118(5):810-21. PMID: 26830849.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  49. Feinberg MW. MicroRNAs as pathophysiological targets: An emerging nexus for personalized medicine in heart failure? Trends Cardiovasc Med. 2016 Feb; 26(2):111-4. PMID: 26166307.
    Citations: 1     Fields:    Translation:HumansCells
  50. Andreou I, Sun X, Stone PH, Edelman ER, Feinberg MW. miRNAs in atherosclerotic plaque initiation, progression, and rupture. Trends Mol Med. 2015 May; 21(5):307-18. PMID: 25771097.
    Citations: 45     Fields:    Translation:Humans
  51. Khedkar SA, Sun X, Rigby AC, Feinberg MW. Discovery of small molecule inhibitors to Krüppel-like factor 10 (KLF10): implications for modulation of T regulatory cell differentiation. J Med Chem. 2015 Feb 12; 58(3):1466-78. PMID: 25581017.
    Citations: 6     Fields:    Translation:HumansCells
  52. Feinberg MW. Fine-tuning innate and adaptive immune responses: another KLFhanger. Focus on "Krüppel-like factor KLF10 regulates transforming growth factor receptor II expression and TGF-ß signaling in CD8+ T lymphocytes". . 2015 Mar 01; 308(5):C359-61. PMID: 25567811.
    Citations: 1     Translation:HumansAnimalsCells
  53. Sun X, Feinberg MW. Regulation of endothelial cell metabolism: just go with the flow. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):13-5. PMID: 25520522.
    Citations: 3     Fields:    Translation:AnimalsCells
  54. Feinberg MW. Healing the injured vessel wall using microRNA-facilitated gene delivery. J Clin Invest. 2014 Sep; 124(9):3694-7. PMID: 25133421.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  55. Sun X, Feinberg MW. MicroRNA-management of lipoprotein homeostasis. Circ Res. 2014 Jun 20; 115(1):2-6. PMID: 24951757.
    Citations: 7     Fields:    Translation:Animals
  56. Icli B, Dorbala P, Feinberg MW. An emerging role for the miR-26 family in cardiovascular disease. Trends Cardiovasc Med. 2014 Aug; 24(6):241-8. PMID: 25066487.
    Citations: 21     Fields:    Translation:HumansCells
  57. Sun X, Belkin N, Feinberg MW. Endothelial microRNAs and atherosclerosis. Curr Atheroscler Rep. 2013 Dec; 15(12):372. PMID: 24158362.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  58. Sun X, Sit A, Feinberg MW. Role of miR-181 family in regulating vascular inflammation and immunity. Trends Cardiovasc Med. 2014 Apr; 24(3):105-12. PMID: 24183793.
    Citations: 65     Fields:    Translation:HumansCells
  59. Sun X, He S, Wara AKM, Icli B, Shvartz E, Tesmenitsky Y, Belkin N, Li D, Blackwell TS, Sukhova GK, Croce K, Feinberg MW. Systemic delivery of microRNA-181b inhibits nuclear factor-?B activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice. Circ Res. 2014 Jan 03; 114(1):32-40. PMID: 24084690.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  60. Icli B, Wara AK, Moslehi J, Sun X, Plovie E, Cahill M, Marchini JF, Schissler A, Padera RF, Shi J, Cheng HW, Raghuram S, Arany Z, Liao R, Croce K, MacRae C, Feinberg MW. MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling. Circ Res. 2013 Nov 08; 113(11):1231-41. PMID: 24047927.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  61. Wara AK, Manica A, Marchini JF, Sun X, Icli B, Tesmenitsky Y, Croce K, Feinberg MW. Bone marrow-derived Kruppel-like factor 10 controls reendothelialization in response to arterial injury. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1552-60. PMID: 23685559.
    Citations: 11     Fields:    Translation:AnimalsCells
  62. Feinberg MW. OutFOXing myeloid cells in atherosclerosis with FoxOs. Circ Res. 2013 Mar 29; 112(7):978-82. PMID: 23538272.
    Citations: 3     Fields:    Translation:AnimalsCells
  63. Sun X, Feinberg MW. NF-?B and hypoxia: a double-edged sword in atherosclerosis. Am J Pathol. 2012 Nov; 181(5):1513-7. PMID: 22999810.
    Citations: 1     Fields:    Translation:Animals
  64. Sun X, Feinberg MW. Knocking out viral myocarditis: reality or a miRage? Circ Res. 2012 Aug 03; 111(4):388-91. PMID: 22859666.
    Citations: 2     Fields:    Translation:HumansAnimals
  65. Sun X, Icli B, Wara AK, Belkin N, He S, Kobzik L, Hunninghake GM, Vera MP, Blackwell TS, Baron RM, Feinberg MW. MicroRNA-181b regulates NF-?B-mediated vascular inflammation. J Clin Invest. 2012 Jun; 122(6):1973-90. PMID: 22622040.
    Citations: 219     Fields:    Translation:HumansAnimalsCells
  66. Wara AK, Croce K, Foo S, Sun X, Icli B, Tesmenitsky Y, Esen F, Rosenzweig A, Feinberg MW. Bone marrow-derived CMPs and GMPs represent highly functional proangiogenic cells: implications for ischemic cardiovascular disease. Blood. 2011 Dec 08; 118(24):6461-4. PMID: 21828132.
    Citations: 24     Fields:    Translation:AnimalsCells
  67. Wara AK, Foo S, Croce K, Sun X, Icli B, Tesmenitsky Y, Esen F, Lee JS, Subramaniam M, Spelsberg TC, Lev EI, Leshem-Lev D, Pande RL, Creager MA, Rosenzweig A, Feinberg MW. TGF-ß1 signaling and Krüppel-like factor 10 regulate bone marrow-derived proangiogenic cell differentiation, function, and neovascularization. Blood. 2011 Dec 08; 118(24):6450-60. PMID: 21828131.
    Citations: 26     Fields:    Translation:AnimalsCells
  68. Cao Z, Sun X, Icli B, Wara AK, Feinberg MW. Role of Kruppel-like factors in leukocyte development, function, and disease. Blood. 2010 Nov 25; 116(22):4404-14. PMID: 20616217.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  69. Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson GK, Spelsberg TC, Libby P, Feinberg MW. Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells. J Biol Chem. 2009 Sep 11; 284(37):24914-24. PMID: 19602726.
    Citations: 48     Fields:    Translation:AnimalsCells
  70. Cao Z, Wara AKM, Icli B, Packard R, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson G, Spelsberg T, Libby P, Feinberg MW. The Kruppel-like Factor KLF10 is protective in atherosclerotic lesion formation and a critical regulator of CD4+CD25– T cells and T regulatory cells through distinct mechanisms. Manuscript in preparation. 2008.
  71. Liu L, Chavan R, Feinberg MB. Dendritic cells are preferentially targeted among hematolymphocytes by Modified Vaccinia Virus Ankara and play a key role in the induction of virus-specific T cell responses in vivo. BMC Immunol. 2008 Apr 15; 9:15. PMID: 18412969.
    Citations: 35     Fields:    Translation:AnimalsCells
  72. Minami M, Shimizu K, Okamoto Y, Folco E, Ilasaca ML, Feinberg MW, Aikawa M, Libby P. Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J Biol Chem. 2008 Apr 11; 283(15):9692-703. PMID: 18270204.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  73. Feinberg MW. Use of myeloid progenitor cell subsets in cardiovascular regeneration. 2008.
  74. Okamoto Y, Folco EJ, Minami M, Wara AK, Feinberg MW, Sukhova GK, Colvin RA, Kihara S, Funahashi T, Luster AD, Libby P. Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res. 2008 Feb 01; 102(2):218-25. PMID: 17991878.
    Citations: 82     Fields:    Translation:HumansCells
  75. Feinberg MW, Wara AK, Cao Z, Lebedeva MA, Rosenbauer F, Iwasaki H, Hirai H, Katz JP, Haspel RL, Gray S, Akashi K, Segre J, Kaestner KH, Tenen DG, Jain MK. The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. EMBO J. 2007 Sep 19; 26(18):4138-48. PMID: 17762869.
    Citations: 132     Fields:    Translation:HumansAnimalsCells
  76. Hamik A, Lin Z, Kumar A, Balcells M, Sinha S, Katz J, Feinberg MW, Gerzsten RE, Edelman ER, Jain MK. Kruppel-like factor 4 regulates endothelial inflammation. J Biol Chem. 2007 May 04; 282(18):13769-79. PMID: 17339326.
    Citations: 160     Fields:    Translation:HumansAnimalsCells
  77. Das H, Kumar A, Lin Z, Patino WD, Hwang PM, Feinberg MW, Majumder PK, Jain MK. Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6653-8. PMID: 16617118.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  78. Feinberg MW. Use of the T regulatory cell modulator Kruppel-like Factor 10 (KLF10) as a novel method to diagnose, monitor, or treat inflammation. 2006.
  79. Feinberg MW. Detection of Organ Rejection using microRNAs. 2006.
  80. Mustafa MU, Cohen M, Zapotulko K, Feinberg M, Miller MF, Aueron F, Wasty N, Tanwir A, Rogal G. The lack of a simple relation between physician's percutaneous coronary intervention volume and outcomes in the era of coronary stenting: a two-centre experience. Int J Clin Pract. 2005 Dec; 59(12):1401-7. PMID: 16351671.
    Citations:    Fields:    Translation:Humans
  81. Feinberg MW, Cao Z, Wara AK, Lebedeva MA, Senbanerjee S, Jain MK. Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages. J Biol Chem. 2005 Nov 18; 280(46):38247-58. PMID: 16169848.
    Citations: 127     Fields:    Translation:AnimalsCells
  82. Feinberg MW, Jain MK. Role of transforming growth factor-beta1/Smads in regulating vascular inflammation and atherogenesis. Panminerva Med. 2005 Sep; 47(3):169-86. PMID: 16462725.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  83. Newman LS, Feinberg MW, LeWine HE. Clinical problem-solving. A bitter tale. N Engl J Med. 2004 Aug 05; 351(6):594-9. PMID: 15295053.
    Citations:    Fields:    Translation:HumansAnimals
  84. Feinberg MW, Lin Z, Fisch S, Jain MK. An emerging role for Krüppel-like factors in vascular biology. Trends Cardiovasc Med. 2004 Aug; 14(6):241-6. PMID: 15451516.
    Citations: 30     Fields:    Translation:HumansCells
  85. Shi C, Zhang X, Chen Z, Sulaiman K, Feinberg MW, Ballantyne CM, Jain MK, Simon DI. Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1. J Clin Invest. 2004 Aug; 114(3):408-18. PMID: 15286807.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  86. SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, García-Cardeña G, Jain MK. KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med. 2004 May 17; 199(10):1305-15. PMID: 15136591.
    Citations: 239     Fields:    Translation:HumansCells
  87. Feinberg MW, Watanabe M, Lebedeva MA, Depina AS, Hanai J, Mammoto T, Frederick JP, Wang XF, Sukhatme VP, Jain MK. Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. J Biol Chem. 2004 Apr 16; 279(16):16388-93. PMID: 14754879.
    Citations: 15     Fields:    Translation:AnimalsCells
  88. Feinberg MW, Shimizu K, Lebedeva M, Haspel R, Takayama K, Chen Z, Frederick JP, Wang XF, Simon DI, Libby P, Mitchell RN, Jain MK. Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. Circ Res. 2004 Mar 19; 94(5):601-8. PMID: 14752027.
    Citations: 35     Fields:    Translation:AnimalsCells
  89. Banerjee SS, Feinberg MW, Watanabe M, Gray S, Haspel RL, Denkinger DJ, Kawahara R, Hauner H, Jain MK. The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis. J Biol Chem. 2003 Jan 24; 278(4):2581-4. PMID: 12426306.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  90. Gray S, Feinberg MW, Hull S, Kuo CT, Watanabe M, Sen-Banerjee S, DePina A, Haspel R, Jain MK. The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J Biol Chem. 2002 Sep 13; 277(37):34322-8. PMID: 12097321.
    Citations: 88     Fields:    Translation:AnimalsCells
  91. Sibinga NE, Feinberg MW, Yang H, Werner F, Jain MK. Macrophage-restricted and interferon gamma-inducible expression of the allograft inflammatory factor-1 gene requires Pu.1. J Biol Chem. 2002 May 03; 277(18):16202-10. PMID: 11861656.
    Citations: 10     Fields:    Translation:AnimalsCells
  92. Kaur A, Alexander L, Staprans SI, Denekamp L, Hale CL, McClure HM, Feinberg MB, Desrosiers RC, Johnson RP. Emergence of cytotoxic T lymphocyte escape mutations in nonpathogenic simian immunodeficiency virus infection. Eur J Immunol. 2001 Nov; 31(11):3207-17. PMID: 11745337.
    Citations: 28     Fields:    Translation:AnimalsCells
  93. Perrella MA, Pellacani A, Layne MD, Patel A, Zhao D, Schreiber BM, Storch J, Feinberg MW, Hsieh CM, Haber E, Lee ME. Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J. 2001 Aug; 15(10):1774-6. PMID: 11481226.
    Citations: 8     Fields:    Translation:AnimalsCells
  94. Pellacani A, Wiesel P, Razavi S, Vasilj V, Feinberg MW, Chin MT, Reeves R, Perrella MA. Down-regulation of high mobility group-I(Y) protein contributes to the inhibition of nitric-oxide synthase 2 by transforming growth factor-beta1. J Biol Chem. 2001 Jan 12; 276(2):1653-9. PMID: 11056164.
    Citations: 11     Fields:    Translation:AnimalsCells
  95. Werner F, Jain MK, Feinberg MW, Sibinga NE, Pellacani A, Wiesel P, Chin MT, Topper JN, Perrella MA, Lee ME. Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3. J Biol Chem. 2000 Nov 24; 275(47):36653-8. PMID: 10973958.
    Citations: 55     Fields:    Translation:AnimalsCells
  96. Feinberg MW, Jain MK, Werner F, Sibinga NE, Wiesel P, Wang H, Topper JN, Perrella MA, Lee ME. Transforming growth factor-beta 1 inhibits cytokine-mediated induction of human metalloelastase in macrophages. J Biol Chem. 2000 Aug 18; 275(33):25766-73. PMID: 10825169.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  97. Shi C, Feinberg MW, Zhang D, Patel A, Sim CU, Dong ZM, Chapman SM, Gutierrez-Ramos JC, Wagner DD, Sibinga NE, Haber E. Donor MHC and adhesion molecules in transplant arteriosclerosis. J Clin Invest. 1999 Feb; 103(4):469-74. PMID: 10021454.
    Citations: 8     Fields:    Translation:Animals
  98. Jain MK, Kashiki S, Hsieh CM, Layne MD, Yet SF, Sibinga NE, Chin MT, Feinberg MW, Woo I, Maas RL, Haber E, Lee ME. Embryonic expression suggests an important role for CRP2/SmLIM in the developing cardiovascular system. Circ Res. 1998 Nov 16; 83(10):980-5. PMID: 9815145.
    Citations: 16     Fields:    Translation:AnimalsCells
  99. Jain MK, Layne MD, Watanabe M, Chin MT, Feinberg MW, Sibinga NE, Hsieh CM, Yet SF, Stemple DL, Lee ME. In vitro system for differentiating pluripotent neural crest cells into smooth muscle cells. J Biol Chem. 1998 Mar 13; 273(11):5993-6. PMID: 9497310.
    Citations: 13     Fields:    Translation:AnimalsCells
  100. Harrer T, Harrer E, Kalams SA, Barbosa P, Barbosa P, Trocha A, Johnson RP, Elbeik T, Feinberg MB, Buchbinder SP, Walker BD. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load. J Immunol. 1996 Apr 01; 156(7):2616-23. PMID: 8786327.
    Citations: 74     Fields:    Translation:HumansCells
  101. Kumar A, Shipley JE, Eiser AS, Feinberg M, Flegel P, Grunhaus L, Haskett RF. Clinical correlates of sleep onset REM periods in depression. Biol Psychiatry. 1987 Dec; 22(12):1477-81. PMID: 3676375.
    Citations: 2     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.