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Pere Puigserver, Ph.D.


Transcriptional Co-activator PGC1alpha Protects Cartilage from Osteoarthritis
Summer, 06/15/15 - 09/07/15

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK117655 (PUIGSERVER, PERE) Mar 21, 2019 - Feb 29, 2024
    Small molecules targeting hepatic glucose production and insulin resistance
    Role: Principal Investigator
  2. R01GM121452 (PUIGSERVER, PERE) Aug 15, 2017 - May 31, 2021
    Metabolic and Bioenergetic Control in Mitochondrial Diseases
    Role: Principal Investigator
  3. R01CA181217 (PUIGSERVER, PERE) Jul 1, 2014 - Mar 31, 2025
    Metabolic and epigenetic dependencies in melanomas during metastasis and targeted-drug resistance
    Role: Principal Investigator
  4. R01DK089883 (PUIGSERVER, PERE) Apr 1, 2011 - Mar 31, 2021
    Energy Expenditure and Metabolic Effects through Brown/Beige Adipose Clk2 Kinase
    Role: Principal Investigator
  5. R03DA032468 (PUIGSERVER, PERE) Mar 1, 2011 - Feb 28, 2014
    HTS of Compounds Modulating PGC-1a Acetylation and Oxidative Metabolic Function
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bennett CF, O'Malley KE, Perry EA, Balsa E, Latorre-Muro P, Riley CL, Luo C, Jedrychowski M, Gygi SP, Puigserver P. Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly. Nat Chem Biol. 2021 Mar 15. PMID: 33723432.
    Citations:    Fields:    
  2. Latorre-Muro P, O'Malley KE, Bennett CF, Perry EA, Balsa E, Tavares CDJ, Jedrychowski M, Gygi SP, Puigserver P. A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation. Cell Metab. 2021 Mar 02; 33(3):598-614.e7. PMID: 33592173.
    Citations:    Fields:    
  3. Perry EA, Bennett CF, Luo C, Balsa E, Jedrychowski M, O'Malley KE, Latorre-Muro P, Ladley RP, Reda K, Wright PM, Gygi SP, Myers AG, Puigserver P. Tetracyclines promote survival and fitness in mitochondrial disease models. Nat Metab. 2021 01; 3(1):33-42. PMID: 33462515.
    Citations:    Translation:HumansAnimalsCells
  4. Lin H, Sharabi K, Lin L, Ruiz C, Zhu D, Cameron MD, Novick SJ, Griffin PR, Puigserver P, Kamenecka TM. Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production. J Med Chem. 2021 01 28; 64(2):980-990. PMID: 33434430.
    Citations:    Fields:    Translation:AnimalsCells
  5. Tavares CDJ, Aigner S, Sharabi K, Sathe S, Mutlu B, Yeo GW, Puigserver P. Transcriptome-wide analysis of PGC-1a-binding RNAs identifies genes linked to glucagon metabolic action. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22204-22213. PMID: 32848060.
    Citations: 2     Fields:    Translation:AnimalsCells
  6. Mutlu B, Puigserver P. GCN5 acetyltransferase in cellular energetic and metabolic processes. Biochim Biophys Acta Gene Regul Mech. 2021 02; 1864(2):194626. PMID: 32827753.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Luo C, Liang J, Sharabi K, Hatting M, Perry EA, Tavares CDJ, Goyal L, Srivastava A, Bilodeau M, Zhu AX, Sicinski P, Puigserver P. Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency. Cancer Res. 2020 08 15; 80(16):3215-3221. PMID: 32606000.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Balsa E, Perry EA, Bennett CF, Jedrychowski M, Gygi SP, Doench JG, Puigserver P. Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death. Nat Commun. 2020 06 01; 11(1):2714. PMID: 32483148.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  9. Luo C, Balsa E, Perry EA, Liang J, Tavares CD, Vazquez F, Widlund HR, Puigserver P. H3K27me3-mediated PGC1a gene silencing promotes melanoma invasion through WNT5A and YAP. J Clin Invest. 2020 02 03; 130(2):853-862. PMID: 31929186.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  10. Cruces-Sande M, Arcones AC, Vila-Bedmar R, Val-Blasco A, Sharabi K, Díaz-Rodríguez D, Puigserver P, Mayor F, Murga C. Autophagy mediates hepatic GRK2 degradation to facilitate glucagon-induced metabolic adaptation to fasting. FASEB J. 2020 01; 34(1):399-409. PMID: 31914606.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Sharabi K, Tavares CDJ, Puigserver P. Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives. Curr Diab Rep. 2019 09 07; 19(10):98. PMID: 31494755.
    Citations: 1     Fields:    Translation:Humans
  12. Balsa E, Soustek MS, Thomas A, Cogliati S, García-Poyatos C, Martín-García E, Jedrychowski M, Gygi SP, Enriquez JA, Puigserver P. ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2a Axis. Mol Cell. 2019 06 06; 74(5):877-890.e6. PMID: 31023583.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  13. Soustek MS, Balsa E, Barrow JJ, Jedrychowski M, Vogel R, Gygi SP, Puigserver P. Inhibition of the ER stress IRE1a inflammatory pathway protects against cell death in mitochondrial complex I mutant cells. Cell Death Dis. 2018 05 31; 9(6):658. PMID: 29855477.
    Citations: 9     Fields:    Translation:HumansCells
  14. Hatting M, Tavares CDJ, Sharabi K, Rines AK, Puigserver P. Insulin regulation of gluconeogenesis. Ann N Y Acad Sci. 2018 01; 1411(1):21-35. PMID: 28868790.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  15. Luo C, Balsa E, Thomas A, Hatting M, Jedrychowski M, Gygi SP, Widlund HR, Puigserver P. ERRa Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1a-Elevated Melanomas. Mol Cancer Res. 2017 10; 15(10):1366-1375. PMID: 28596418.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  16. Sharabi K, Lin H, Tavares CDJ, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P. Selective Chemical Inhibition of PGC-1a Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017 03 23; 169(1):148-160.e15. PMID: 28340340.
    Citations: 37     Fields:    Translation:AnimalsCells
  17. Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017 03 09; 543(7644):252-256. PMID: 28219080.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  18. Hatting M, Rines AK, Luo C, Tabata M, Sharabi K, Hall JA, Verdeguer F, Trautwein C, Puigserver P. Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting. Cell Metab. 2017 02 07; 25(2):428-437. PMID: 28089567.
    Citations: 9     Fields:    Translation:AnimalsCells
  19. Luo C, Widlund HR, Puigserver P. PGC-1 Coactivators: Shepherding the Mitochondrial Biogenesis of Tumors. Trends Cancer. 2016 10; 2(10):619-631. PMID: 28607951.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  20. Barrow JJ, Balsa E, Verdeguer F, Tavares CD, Soustek MS, Hollingsworth LR, Jedrychowski M, Vogel R, Paulo JA, Smeitink J, Gygi SP, Doench J, Root DE, Puigserver P. Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations. Mol Cell. 2016 10 06; 64(1):163-175. PMID: 27666594.
    Citations: 10     Fields:    Translation:HumansCells
  21. Luo C, Lim JH, Lee Y, Granter SR, Thomas A, Vazquez F, Widlund HR, Puigserver P. A PGC1a-mediated transcriptional axis suppresses melanoma metastasis. Nature. 2016 09 15; 537(7620):422-426. PMID: 27580028.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  22. Rines AK, Sharabi K, Tavares CD, Puigserver P. Targeting hepatic glucose metabolism in the treatment of type 2 diabetes. Nat Rev Drug Discov. 2016 11; 15(11):786-804. PMID: 27516169.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  23. Luo C, Puigserver P, Widlund HR. Breaking BRAF(V600E)-drug resistance by stressing mitochondria. Pigment Cell Melanoma Res. 2016 07; 29(4):401-3. PMID: 27135210.
    Citations: 2     Fields:    Translation:HumansCells
  24. Tavares CD, Sharabi K, Dominy JE, Lee Y, Isasa M, Orozco JM, Jedrychowski MP, Kamenecka TM, Griffin PR, Gygi SP, Puigserver P. The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1a Transcriptional Coactivator. J Biol Chem. 2016 May 13; 291(20):10635-45. PMID: 27022023.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  25. Luo C, Puigserver P. Stem cells: Dietary fat promotes intestinal dysregulation. Nature. 2016 Mar 03; 531(7592):42-3. PMID: 26935693.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  26. Lee G, Won HS, Lee YM, Choi JW, Oh TI, Jang JH, Choi DK, Lim BO, Kim YJ, Park JW, Puigserver P, Lim JH. Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1a Activation. Sci Rep. 2016 Jan 07; 6:18928. PMID: 26740011.
    Citations: 32     Fields:    Translation:HumansCells
  27. Balsa-Martinez E, Puigserver P. Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth. Mol Cell. 2015 Nov 19; 60(4):509-11. PMID: 26590709.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  28. Sharabi K, Tavares CD, Rines AK, Puigserver P. Molecular pathophysiology of hepatic glucose production. Mol Aspects Med. 2015 Dec; 46:21-33. PMID: 26549348.
    Citations: 46     Fields:    Translation:HumansCells
  29. Verdeguer F, Soustek MS, Hatting M, Blättler SM, McDonald D, Barrow JJ, Puigserver P. Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity. Mol Cell Biol. 2015 Oct 26; 36(1):184-96. PMID: 26503783.
    Citations: 13     Fields:    Translation:AnimalsCells
  30. Soustek MS, Puigserver P. Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity. EMBO J. 2015 Apr 15; 34(8):981-3. PMID: 25736377.
    Citations:    Fields:    Translation:HumansAnimalsCells
  31. Rines AK, Verdeguer F, Puigserver P. Adenosine activates thermogenic adipocytes. Cell Res. 2015 Feb; 25(2):155-6. PMID: 25449131.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  32. Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature. 2014 Jun 26; 510(7506):547-51. PMID: 24870244.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  33. Lim JH, Luo C, Vazquez F, Puigserver P. Targeting mitochondrial oxidative metabolism in melanoma causes metabolic compensation through glucose and glutamine utilization. Cancer Res. 2014 Jul 01; 74(13):3535-45. PMID: 24812272.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  34. Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10; 508(7495):258-62. PMID: 24717514.
    Citations: 131     Fields:    Translation:AnimalsCells
  35. Hall JA, Tabata M, Rodgers JT, Puigserver P. USP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy. Mol Endocrinol. 2014 Jun; 28(6):912-24. PMID: 24694308.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  36. Chow JD, Lawrence RT, Healy ME, Dominy JE, Liao JA, Breen DS, Byrne FL, Kenwood BM, Lackner C, Okutsu S, Mas VR, Caldwell SH, Tomsig JL, Cooney GJ, Puigserver PB, Turner N, James DE, Villén J, Hoehn KL. Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation. Mol Metab. 2014 Jul; 3(4):419-31. PMID: 24944901.
    Citations: 28     Fields:    
  37. Verdeguer F, Blättler SM, Cunningham JT, Hall JA, Chim H, Puigserver P. Decreased genetic dosage of hepatic Yin Yang 1 causes diabetic-like symptoms. Mol Endocrinol. 2014 Mar; 28(3):308-16. PMID: 24467246.
    Citations: 2     Fields:    Translation:AnimalsCells
  38. Tabata M, Rodgers JT, Hall JA, Lee Y, Jedrychowski MP, Gygi SP, Puigserver P. Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1a and MED1 complex. Diabetes. 2014 May; 63(5):1519-32. PMID: 24458359.
    Citations: 14     Fields:    Translation:AnimalsCells
  39. Dominy JE, Puigserver P. Mitochondrial biogenesis through activation of nuclear signaling proteins. Cold Spring Harb Perspect Biol. 2013 Jul 01; 5(7). PMID: 23818499.
    Citations: 63     Fields:    Translation:HumansCells
  40. Hall JA, Dominy JE, Lee Y, Puigserver P. The sirtuin family's role in aging and age-associated pathologies. J Clin Invest. 2013 Mar; 123(3):973-9. PMID: 23454760.
    Citations: 74     Fields:    Translation:HumansAnimals
  41. Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, Puigserver P. PGC1a expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell. 2013 Mar 18; 23(3):287-301. PMID: 23416000.
    Citations: 252     Fields:    Translation:HumansAnimalsCells
  42. Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P. Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1a complex. J Biol Chem. 2013 Mar 08; 288(10):7117-26. PMID: 23329830.
    Citations: 58     Fields:    Translation:AnimalsCells
  43. Dominy J, Puigserver P, Cantó C. In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity. Methods Mol Biol. 2013; 1077:217-37. PMID: 24014410.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  44. Dominy JE, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol Cell. 2012 Dec 28; 48(6):900-13. PMID: 23142079.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  45. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110. PMID: 23021218.
    Citations: 124     Fields:    Translation:AnimalsCells
  46. Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP. A metabolic prosurvival role for PML in breast cancer. J Clin Invest. 2012 Sep; 122(9):3088-100. PMID: 22886304.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  47. Blättler SM, Verdeguer F, Liesa M, Cunningham JT, Vogel RO, Chim H, Liu H, Romanino K, Shirihai OS, Vazquez F, Rüegg MA, Shi Y, Puigserver P. Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Mol Cell Biol. 2012 Aug; 32(16):3333-46. PMID: 22711985.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  48. Blättler SM, Cunningham JT, Verdeguer F, Chim H, Haas W, Liu H, Romanino K, Rüegg MA, Gygi SP, Shi Y, Puigserver P. Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metab. 2012 Apr 04; 15(4):505-17. PMID: 22482732.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  49. Dominy JE, Gerhart-Hines Z, Puigserver P. Nutrient-dependent acetylation controls basic regulatory metabolic switches and cellular reprogramming. Cold Spring Harb Symp Quant Biol. 2011; 76:203-9. PMID: 22371372.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  50. Dominy JE, Vazquez F, Puigserver P. Glycine decarboxylase cleaves a "malignant" metabolic path to promote tumor initiation. Cancer Cell. 2012 Feb 14; 21(2):143-5. PMID: 22340586.
    Citations: 2     Fields:    
  51. Gerhart-Hines Z, Dominy JE, Blättler SM, Jedrychowski MP, Banks AS, Lim JH, Chim H, Gygi SP, Puigserver P. The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Mol Cell. 2011 Dec 23; 44(6):851-63. PMID: 22195961.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  52. Romanino K, Mazelin L, Albert V, Conjard-Duplany A, Lin S, Bentzinger CF, Handschin C, Puigserver P, Zorzato F, Schaeffer L, Gangloff YG, Rüegg MA. Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20808-13. PMID: 22143799.
    Citations: 18     Fields:    Translation:AnimalsCells
  53. Bhalla K, Hwang BJ, Dewi RE, Ou L, Twaddel W, Fang HB, Vafai SB, Vazquez F, Puigserver P, Boros L, Girnun GD. PGC1a promotes tumor growth by inducing gene expression programs supporting lipogenesis. Cancer Res. 2011 Nov 01; 71(21):6888-98. PMID: 21914785.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  54. Kelly TJ, Souza AL, Clish CB, Puigserver P. A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol. 2011 Jul; 31(13):2696-706. PMID: 21555452.
    Citations: 85     Fields:    Translation:HumansCells
  55. Rodgers JT, Vogel RO, Puigserver P. Clk2 and B56ß mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt. Mol Cell. 2011 Feb 18; 41(4):471-9. PMID: 21329884.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  56. Dominy JE, Puigserver P. Nuclear FoxO1 inflames insulin resistance. EMBO J. 2010 Dec 15; 29(24):4068-9. PMID: 21157481.
    Citations: 3     Fields:    Translation:AnimalsCells
  57. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 01; 24(13):1403-17. PMID: 20595232.
    Citations: 154     Fields:    Translation:HumansAnimalsCells
  58. Rodgers JT, Haas W, Gygi SP, Puigserver P. Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Cell Metab. 2010 Jan; 11(1):23-34. PMID: 20074525.
    Citations: 63     Fields:    Translation:AnimalsCells
  59. Dominy JE, Lee Y, Gerhart-Hines Z, Puigserver P. Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5. Biochim Biophys Acta. 2010 Aug; 1804(8):1676-83. PMID: 20005308.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  60. Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med. 2009 Nov; 15(11):1307-11. PMID: 19838201.
    Citations: 122     Fields:    Translation:AnimalsCells
  61. Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature. 2009 Sep 03; 461(7260):109-13. PMID: 19693011.
    Citations: 392     Fields:    Translation:HumansCells
  62. Kelly TJ, Lerin C, Haas W, Gygi SP, Puigserver P. GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. J Biol Chem. 2009 Jul 24; 284(30):19945-52. PMID: 19491097.
    Citations: 50     Fields:    Translation:HumansCells
  63. Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009 Apr 23; 458(7241):1056-60. PMID: 19262508.
    Citations: 1002     Fields:    Translation:AnimalsCells
  64. Rodgers JT, Puigserver P. Insulin resistance: beta-arrestin development. Cell Res. 2009 Mar; 19(3):275-6. PMID: 19252509.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  65. Housley MP, Udeshi ND, Rodgers JT, Shabanowitz J, Puigserver P, Hunt DF, Hart GW. A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose. J Biol Chem. 2009 Feb 20; 284(8):5148-57. PMID: 19103600.
    Citations: 85     Fields:    Translation:HumansCells
  66. Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Commun. 2009 Jan 23; 378(4):836-41. PMID: 19071085.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  67. Coste A, Louet JF, Lagouge M, Lerin C, Antal MC, Meziane H, Schoonjans K, Puigserver P, O'Malley BW, Auwerx J. The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17187-92. PMID: 18957541.
    Citations: 87     Fields:    Translation:AnimalsCells
  68. Housley MP, Rodgers JT, Udeshi ND, Kelly TJ, Shabanowitz J, Hunt DF, Puigserver P, Hart GW. O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem. 2008 Jun 13; 283(24):16283-92. PMID: 18420577.
    Citations: 134     Fields:    Translation:HumansAnimals
  69. J. T. Rodgers, C. Lerin, Z. Gerhart-Hines and P. Puigserver. Metabolic Adaptations Through PGC-1α and SIRT1 Pathways. FEBS Letters. 2008; 582:46-53.
  70. Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature. 2007 Nov 29; 450(7170):736-40. PMID: 18046414.
    Citations: 534     Fields:    Translation:AnimalsCells
  71. Rodgers JT, Lerin C, Gerhart-Hines Z, Puigserver P. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett. 2008 Jan 09; 582(1):46-53. PMID: 18036349.
    Citations: 229     Fields:    Translation:AnimalsCells
  72. Rodgers JT, Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12861-6. PMID: 17646659.
    Citations: 238     Fields:    Translation:Animals
  73. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11; 26(13):3169-79. PMID: 17581637.
    Citations: 404     Fields:    Translation:HumansAnimalsCells
  74. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 2007 Apr 04; 26(7):1913-23. PMID: 17347648.
    Citations: 481     Fields:    Translation:AnimalsCells
  75. Rodgers JT, Puigserver P. Receptor feasts on sugar and cholesterol. Nat Med. 2007 Feb; 13(2):128-9. PMID: 17290267.
    Citations: 1     Fields:    Translation:HumansCells
  76. J.T. Rodgers and P. Puigserver. Fasting-Dependent Glucose and Lipid Metabolic Response through Hepatic SIRT1. Proc. Natl. Acad. Sci. USA. 2007; 104(31):12861-66.
  77. J.T. Cunningham, J.T. Rodgers, D. Arlow, F. Vazquez, V.K. Mootha and P. Puigserver. mTOR controls mitochondrial oxidative function through a YY1/PGC-1α complex. Nature. 2007; 450:736-740.
  78. Z. Gerhart-Hines, J.T. Rodgers, O. Bare, C. Lerin, S.H. Kim, R. Mostoslavsky, F.W. Alt, Z. Wu and P. Puigserver. Metabolic Control of Mitochondrial Function and Fatty Acid Oxidation Through PGC-1α/SIRT1. EMBO J. 2007; 26:1913-1923.
  79. P. Puigserver and C.R. Kahn. Mammalian Metabolism in Aging. Molecular Biology of Aging. Edited by L. Guarente, L. Partridge and D.C. Wallace. Cold Spring Harbor Monograph Series. 2007; 51.
  80. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15; 127(6):1109-22. PMID: 17112576.
    Citations: 1358     Fields:    Translation:HumansAnimalsCells
  81. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16; 444(7117):337-42. PMID: 17086191.
    Citations: 1416     Fields:    Translation:AnimalsCells
  82. Cha SH, Rodgers JT, Puigserver P, Chohnan S, Lane MD. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15410-5. PMID: 17030788.
    Citations: 17     Fields:    Translation:AnimalsCells
  83. Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006 Aug 04; 281(31):21745-21754. PMID: 16751189.
    Citations: 228     Fields:    Translation:HumansAnimalsCells
  84. Lerin C, Rodgers JT, Kalume DE, Kim SH, Pandey A, Puigserver P. GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab. 2006 Jun; 3(6):429-38. PMID: 16753578.
    Citations: 187     Fields:    Translation:HumansAnimalsCells
  85. Rodgers JT, Puigserver P. Certainly can't live without this: SIRT6. Cell Metab. 2006 Feb; 3(2):77-8. PMID: 16459306.
    Citations: 9     Fields:    Translation:AnimalsCells
  86. Puigserver P, Rodgers JT. Foxa2, a novel transcriptional regulator of insulin sensitivity. Nat Med. 2006 Jan; 12(1):38-9. PMID: 16397559.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  87. M. Lagouge, Argmann, C., Gerhart-Hines, Z., Meziane, H., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Lerin, C., Geny, B., Laakso, M., Puigserver, P., Auwerx, J. Resveratrol promotes mitochondrial biogenesis and protects against metabolic disease through activating SIRT1 and PGC-1α activity. Cell. 2006; 127(6):1109-22.
  88. S.H. Cha, Rodgers J.T., Puigserver, P., Chohnan, S. and Lane, M.D. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1α. Proc. Natl. Acad. Sci. 2006; 103(42):15410-5.
  89. J. T. Rodgers and P. Puigserver. Certainly you can’t live without it: SIRT6. Cell Metabolism. 2006; 3(2):77-8.
  90. Pere Puigserver, Joseph T. Rodgers, Jill Milne and Karl Normington. Modulators of cdc2-like kinases (CLKs) and methods of use thereof. 2005.
  91. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005 Mar 03; 434(7029):113-8. PMID: 15744310.
    Citations: 1182     Fields:    Translation:AnimalsCells
  92. Puigserver P. Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha. Int J Obes (Lond). 2005 Mar; 29 Suppl 1:S5-9. PMID: 15711583.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  93. P. Puigserver. Tissue-Specific Regulation of Metabolic Pathways Through the Transcriptional Coactivator PGC-1α. Int. J. Obes. Relat. Metab. Disord. 2005; 29:S5-9.
  94. J.T. Rodgers, C. Lerin, W. Haas, S.P. Gygi, B.M. Spiegelman and P.Puigserver. Nutrient Control of Gluconeogenesis Through PGC-1α/SIRT1 Deacetylase Complex. Nature. 2005; 434:113-8.
  95. Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6570-5. PMID: 15100410.
    Citations: 266     Fields:    Translation:AnimalsCells
  96. Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol. 2004 Apr; 24(7):3057-67. PMID: 15024092.
    Citations: 205     Fields:    Translation:HumansAnimalsCells
  97. Fan M, Rhee J, St-Pierre J, Handschin C, Puigserver P, Lin J, Jäeger S, Erdjument-Bromage H, Tempst P, Spiegelman BM. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev. 2004 Feb 01; 18(3):278-89. PMID: 14744933.
    Citations: 113     Fields:    Translation:AnimalsCells
  98. M. Fan, J. Rhee, J. St-Pierre, C. Handshin, P. Puigserver, J. Lin, S. Jaeger, H. Erdjument-Bromage, P. Tempst and B. M. Spiegelman. Suppression of Mitochondrial Respiration via p160 Myb Binding Protein Docking on PGC-1α: Modulation by p38 MAPK. Genes Dev. 2004; 18:278-289.
  99. V.K. Mootha, C. Handschin, D. Arlow, X. Xie, J. St Pierre, S. Sihag, W. Yang, D. Altshuler, P. Puigserver, N. Patterson, P.J. Willy, I.G. Schulman, R.A. Heyman, E.S. Lander, B.M. Spiegelman. ERRalpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc. Natl. Acad. Sci. USA. 2004; 101:6570-5.
  100. W. Cao, K.W. Daniel, J. Rabidoux, P. Puigserver, A.V. Medvedev, X. Bai, L.M. Floering, B.M. Spiegelman and S. Collins. p38 Mitogen-Activated Protein Kinase is the Central Regulator of cAMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene. Mol.Cell Biol. 2004; 24:3057-3067.
  101. Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell. 2003 Jul; 5(1):73-83. PMID: 12852853.
    Citations: 60     Fields:    Translation:AnimalsCells
  102. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003 Jul; 34(3):267-73. PMID: 12808457.
    Citations: 2913     Fields:    Translation:HumansAnimalsCells
  103. Lin J, Tarr PT, Yang R, Rhee J, Puigserver P, Newgard CB, Spiegelman BM. PGC-1beta in the regulation of hepatic glucose and energy metabolism. J Biol Chem. 2003 Aug 15; 278(33):30843-8. PMID: 12807885.
    Citations: 95     Fields:    Translation:AnimalsCells
  104. Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 2003 May 29; 423(6939):550-5. PMID: 12754525.
    Citations: 521     Fields:    Translation:AnimalsCells
  105. Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, Spiegelman BM. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4012-7. PMID: 12651943.
    Citations: 211     Fields:    Translation:AnimalsCells
  106. Puigserver P, Spiegelman BM. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev. 2003 Feb; 24(1):78-90. PMID: 12588810.
    Citations: 642     Fields:    Translation:HumansAnimalsCells
  107. Tritos NA, Mastaitis JW, Kokkotou EG, Puigserver P, Spiegelman BM, Maratos-Flier E. Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain. Brain Res. 2003 Jan 31; 961(2):255-60. PMID: 12531492.
    Citations: 11     Fields:    Translation:Animals
  108. B.M. Spiegelman and P. Puigserver. PGC-1α: Metabolic Regulator and Transcriptional Coactivator. Endocr. Rev. 2003; 24(1):78-90.
  109. J. Cliff Yoon, G. Xu, J.T. Deeny, S. Yang, J. Rhee, P. Puigserver, R. Yang, C. Zhang, B.B. Lowell, P.O. Berggren, C.B. Newgard, S. Bonner-Weir, G. Weir and B. M. Spiegelman. Suppression of β-Cell Energy Metabolism and Insulin release by PGC-1α. Dev. Cell. 2003; 5:73-83.
  110. P. Puigserver, J. Rhee, J. Donovan, C.J. Walkey, J.C. Yoon, F. Oriente, Y. Kitamura, J. Altomonte, H. Dong, D. Accili and B.M. Spiegelman. Insulin-Regulated Hepatic Gluconeogenesis Through FOXO1/PGC-1α Interaction. Nature. 2003; 423:550-5.
  111. J. Rhee, Y. Inoue, J.C. Yoon, P. Puigserver, M. Fan, F.J. Gonzalez, B.M. Spiegelman. Regulation of hepatic fasting response by PPARgamma coactivator-1 alpha (PGC-1): Requirement for hepatocyte nuclear factor 4 alpha in gluconeogenesis. Proc. Natl. Acad. Sci. USA. 2003; 100:4012-7.
  112. Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature. 2002 Aug 15; 418(6899):797-801. PMID: 12181572.
    Citations: 890     Fields:    Translation:AnimalsCells
  113. J. Lin, H. Wu, P. Tarr, C.Y. Zhang, Z. Wu, O. Boss, L.F. Michael, P. Puigserver, E. Isotani, E. N. Olson, B. Lowell, R. Bassel-Duby and B.M. Spiegelman. Transcriptional Co-activator PGC-1α drives the formation of slow-twitch muscle fibers. Nature. 2002; 418:797-801.
  114. J. Lin, P. Puigserver, J. Donovan, P. Tarr and B.M. Spiegelman. PGC-1β: A novel transcription coactivator associated with host cell factor. J. Biol. Chem. 2002; 277:1645-1648.
  115. Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem. 2002 Jan 18; 277(3):1645-8. PMID: 11733490.
    Citations: 197     Fields:    Translation:AnimalsCells
  116. Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell. 2001 Nov; 8(5):971-82. PMID: 11741533.
    Citations: 258     Fields:    Translation:HumansAnimalsCells
  117. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):131-8. PMID: 11557972.
    Citations: 628     Fields:    Translation:AnimalsCells
  118. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):179-83. PMID: 11557984.
    Citations: 513     Fields:    Translation:HumansAnimalsCells
  119. Michael LF, Wu Z, Cheatham RB, Puigserver P, Adelmant G, Lehman JJ, Kelly DP, Spiegelman BM. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3820-5. PMID: 11274399.
    Citations: 216     Fields:    Translation:AnimalsCells
  120. S. Herzig, F. Long, U. Jhala, S. Hedrick, R. Quinn, A. Bauer, D. Rudolph, G. Schutz, J.C. Yoon, P. Puigserver, B.M. Spiegelman, and M. Montminy. CREB Regulates Hepatic Gluconeogenesis via the Co-activator PGC-1. Nature. 2001; 413:179-183.
  121. L.F. Michael, Z. Wu, R.B. Cheatham, P. Puigserver, G. Adelmant, J.J. Lehman, D.P. Kelly, and B.M. Spiegelman. Restoration of Insulin-Sensitive Glucose Transporter (GLUT-4) Gene Expression in Muscle Cells by the Transcriptional Coactivator PGC-1. Proc. Natl. Acad. Sci. 2001; 98:3820-3825.
  122. P. Puigserver, ,J. Rhee, J. Lin, Z. Wu, J.C. Yoon, C. Zhang, S. Krauss, V. Mootha. B.B. Lowell and B. M. Spiegelman. Cytokine-Activation of Energy Expenditure through p38 MAP kinase phosphorylation of the PPARγ coactivator (PGC-1). Mol. Cell. 2001; 8:971-982.
  123. Spiegelman BM, Puigserver P, Wu Z. Regulation of adipogenesis and energy balance by PPARgamma and PGC-1. Int J Obes Relat Metab Disord. 2000 Nov; 24 Suppl 4:S8-10. PMID: 11126248.
    Citations: 34     Fields:    Translation:HumansCells
  124. Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM. Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol Cell. 2000 Aug; 6(2):307-16. PMID: 10983978.
    Citations: 137     Fields:    Translation:HumansAnimalsCells
  125. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes Dev. 2000 Jun 01; 14(11):1293-307. PMID: 10837022.
    Citations: 522     Fields:    Translation:HumansAnimalsCells
  126. Tcherepanova I, Puigserver P, Norris JD, Spiegelman BM, McDonnell DP. Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. J Biol Chem. 2000 May 26; 275(21):16302-8. PMID: 10748020.
    Citations: 71     Fields:    Translation:HumansCells
  127. B. M. Spiegelman, P. Puigserver, Z. Wu. Regulation of adipogenesis and energy balance by PPARγ and PGC-1. Int. J. Obes. Relat. Metab. Disord. 2000; 24(4):S8-10.
  128. Wu Z, Puigserver P, Spiegelman BM. Transcriptional activation of adipogenesis. Curr Opin Cell Biol. 1999 Dec; 11(6):689-94. PMID: 10600710.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  129. Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM. Activation of PPARgamma coactivator-1 through transcription factor docking. Science. 1999 Nov 12; 286(5443):1368-71. PMID: 10558993.
    Citations: 216     Fields:    Translation:AnimalsCells
  130. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 1999 Jul 09; 98(1):115-24. PMID: 10412986.
    Citations: 1305     Fields:    Translation:AnimalsCells
  131. Serra F, Bonet ML, Puigserver P, Oliver J, Palou A. Stimulation of uncoupling protein 1 expression in brown adipocytes by naturally occurring carotenoids. Int J Obes Relat Metab Disord. 1999 Jun; 23(6):650-5. PMID: 10411240.
    Citations: 11     Fields:    Translation:AnimalsCells
  132. B.M. Spiegelman, G. Castillo, S. Hauser and P. Puigserver. Regulation of energy balance by PPARγ and its coactivators. Progress in Obesity Research. Edited by B. Guy-Grand and G. Ailhaud. 1999; 39-46.
  133. F. Serra, M.L. Bonet, P. Puigserver, J. Oliver, A. Palou. Stimulation of uncoupling protein 1 expression in brown adipocyte by naturally occurring carotenoids. Int. J. Obes. Relat. Metab. Disord. 1999; 23:650-5.
  134. P. Puigserver, G. Adelmant, Z. Wu, M. Fan, J. Xu, B. O’Malley, B.M. Spiegelman. Activation of PPARγ Coactivator (PGC-1) Through Transcription Factor Docking. Science. 1999; 286(5443):1368-71.
  135. Picó C, Puigserver P, Oliver P, Palou A. 2-Methoxyestradiol, an endogenous metabolite of 17beta-estradiol, inhibits adipocyte proliferation. Mol Cell Biochem. 1998 Dec; 189(1-2):1-7. PMID: 9879647.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  136. Puigserver P, Ribot J, Serra F, Gianotti M, Bonet ML, Nadal-Ginard B, Palou A. Involvement of the retinoblastoma protein in brown and white adipocyte cell differentiation: functional and physical association with the adipogenic transcription factor C/EBPalpha. Eur J Cell Biol. 1998 Oct; 77(2):117-23. PMID: 9840461.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  137. Bruce M. Spiegelman, Pere Puigserver and Zhidan Wu. PGC-1alpha. Novel Brown Fat PPARgamma coactivator. 1998.
  138. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998 Mar 20; 92(6):829-39. PMID: 9529258.
    Citations: 1201     Fields:    Translation:AnimalsCells
  139. C. Pico, P. Puigserver, P. Oliver, A. Palou. 2-Methoxyoestradiol, an endogenous metabolite of 17-β-estradiol, inhibits adipocyte proliferation. Mol. Cell. Biochem. 1998; 189:1-7.
  140. Garcia-Palmer FJ, Pericas J, Matamala JC, Puigserver P, Bonet ML, Palou A, Gianotti M. Diminished response to food deprivation of the rat brown adipose tissue mitochondrial uncoupling system with age. Biochem Mol Biol Int. 1997 Sep; 42(6):1151-61. PMID: 9305533.
    Citations:    Fields:    Translation:AnimalsCells
  141. Bonet ML, Puigserver P, Serra F, Ribot J, Vázquez F, Pico C, Palou A. Retinoic acid modulates retinoid X receptor alpha and retinoic acid receptor alpha levels of cultured brown adipocytes. FEBS Lett. 1997 Apr 07; 406(1-2):196-200. PMID: 9109417.
    Citations: 8     Fields:    Translation:AnimalsCells
  142. F.J. Garcia-Palmer, J. Pericas, J.C. Matamala, P. Puigserver, M.L. Bonet, A Palou, M. Gianotti. Diminished response to food deprivation of the rat brown adipose tissue mitochondrial uncoupling system with age. Biochem. Mol. Biol. Int. 1997; 42:1151-1161.
  143. M.L. Bonet, P. Puigserver, F. Serra, F. Vazquez, C. Pico, A. Palou. Retinoic acid modulates RARα and RXRα levels in cultured brown adipocytes. FEBS Lett. 1997; 406:196-200.
  144. Puigserver P, Vázquez F, Bonet ML, Picó C, Palou A. In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid. Biochem J. 1996 Aug 01; 317 ( Pt 3):827-33. PMID: 8760369.
    Citations: 27     Fields:    Translation:AnimalsCells
  145. Puigserver P, Picó C, Stock MJ, Palou A. Effect of selective beta-adrenoceptor stimulation on UCP synthesis in primary cultures of brown adipocytes. Mol Cell Endocrinol. 1996 Mar 01; 117(1):7-16. PMID: 8734469.
    Citations: 7     Fields:    Translation:AnimalsCells
  146. P. Puigserver, F. Vazquez, M.L. Bonet, C. Pico, A. Palou. In vitro an in vivo induction of the uncoupling protein thermogenin by retinoids. Biochem. J. 1996; 317:827-833.
  147. P. Puigserver, C. Pico, M.J. Stock, A. Palou. Effect of selective ß-adrenoceptor stimulation on UCP expression in primary cultures of brown adipocytes. Mol. Cell Endocrinol. 1996; 117:7-16.
  148. Moreno M, Puigserver P, Llull J, Gianotti M, Lanni A, Goglia F, Palou A. Cold exposure induces different uncoupling-protein thermogenin masking/unmasking processes in brown adipose tissue depending on mitochondrial subtypes. Biochem J. 1994 Jun 01; 300 ( Pt 2):463-8. PMID: 8002952.
    Citations: 7     Fields:    Translation:AnimalsCells
  149. Puigserver P, Palou A, Gianotti M. Dietary regulation of fasting-induced mitochondrial protein degradation in adult rat brown adipose tissue. Biochem Int. 1992 Sep; 27(6):1037-46. PMID: 1332718.
    Citations:    Fields:    Translation:AnimalsCells
  150. Puigserver P, Herron D, Gianotti M, Palou A, Cannon B, Nedergaard J. Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool. Biochem J. 1992 Jun 01; 284 ( Pt 2):393-8. PMID: 1599423.
    Citations: 30     Fields:    Translation:AnimalsCells
  151. Puigserver P, Gianotti M, Palou A. Impaired starvation-induced loss of mitochondrial protein in the brown adipose tissue of dietary obese rats. Int J Obes Relat Metab Disord. 1992 Apr; 16(4):255-61. PMID: 1318279.
    Citations: 3     Fields:    Translation:AnimalsCells
  152. Pere Puigserver. Adrenergic stimulation and obesity status regulate induction and degradation of the thermogenic uncoupling protein in brown adipose in-vitro and in-vivo. 1992.
  153. P. Puigserver, A. Palou, M. Gianotti. Impaired starvation-induced loss of mitochondrial protein in the brown adipose tissue of dietary obese rats. Int. J. Obes. 1992; 16:255-261.
  154. Puigserver P, Lladó I, Palou A, Gianotti M. Evidence for masking of brown adipose tissue mitochondrial GDP-binding sites in response to fasting in rats made obese by dietary manipulation. Effects of reversion to standard diet. Biochem J. 1991 Oct 15; 279 ( Pt 2):575-9. PMID: 1953651.
    Citations: 8     Fields:    Translation:AnimalsCells
  155. J. Nedergaard, M. Néchad, S. Rehnmark, D. Herron, A. Jacobsson, P. Kuusela, P. Puigserver, J. Houstek, G. Bronnikov and B. Cannon. Adrenergic regulation of differentiation and proliferation in brown adipocyte cultures. Obesity in Europe. Edited by G. Ailhaud et al. 1991; 355-361.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.