Harvard Catalyst Profiles

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Pere Puigserver, Ph.D.


Transcriptional Co-activator PGC1alpha Protects Cartilage from Osteoarthritis
Summer, 06/15/15 - 09/07/15

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56AG074527 (PUIGSERVER, PERE) Sep 1, 2021 - Aug 31, 2022
    Mitochondrial Protein Translation Signaling and Survival Mechanisms
    Role: Principal Investigator
  2. R01DK117655 (PUIGSERVER, PERE) Mar 21, 2019 - Feb 29, 2024
    Small molecules targeting hepatic glucose production and insulin resistance
    Role: Principal Investigator
  3. R01GM121452 (PUIGSERVER, PERE) Aug 15, 2017 - May 31, 2021
    Metabolic and Bioenergetic Control in Mitochondrial Diseases
    Role: Principal Investigator
  4. R01CA181217 (PUIGSERVER, PERE) Jul 1, 2014 - Mar 31, 2025
    Metabolic and epigenetic dependencies in melanomas during metastasis and targeted-drug resistance
    Role: Principal Investigator
  5. R01DK089883 (PUIGSERVER, PERE) Apr 1, 2011 - Mar 31, 2021
    Energy Expenditure and Metabolic Effects through Brown/Beige Adipose Clk2 Kinase
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhang L, Hobeika CS, Khabibullin D, Yu D, Filippakis H, Alchoueiry M, Tang Y, Lam HC, Tsvetkov P, Georgiou G, Lamb C, Stone E, Puigserver P, Priolo C, Henske EP. Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11. Proc Natl Acad Sci U S A. 2022 07 12; 119(28):e2122840119. PMID: 35867762; PMCID: PMC9651629.
    Citations:    Fields:    Translation:Humans
  2. Bennett CF, Latorre-Muro P, Puigserver P. Mechanisms of mitochondrial respiratory adaptation. Nat Rev Mol Cell Biol. 2022 Dec; 23(12):817-835. PMID: 35804199.
    Citations:    Fields:    
  3. Latorre-Muro P, Puigserver P. Atossa: a royal link between OXPHOS metabolism and macrophage migration. EMBO J. 2022 06 14; 41(12):e111290. PMID: 35466422; PMCID: PMC9194787.
    Citations: 1     Fields:    Translation:Cells
  4. Mutlu B, Puigserver P. Controversies surrounding peripheral cannabinoid receptor 1 in fatty liver disease. J Clin Invest. 2021 11 15; 131(22). PMID: 34779413; PMCID: PMC8592531.
    Citations:    Fields:    Translation:HumansCells
  5. Bennett CF, Ronayne CT, Puigserver P. Targeting adaptive cellular responses to mitochondrial bioenergetic deficiencies in human disease. FEBS J. 2022 Nov; 289(22):6969-6993. PMID: 34510753; PMCID: PMC8917243.
    Citations: 1     Fields:    
  6. Bennett CF, O'Malley KE, Perry EA, Balsa E, Latorre-Muro P, Riley CL, Luo C, Jedrychowski M, Gygi SP, Puigserver P. Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly. Nat Chem Biol. 2021 06; 17(6):703-710. PMID: 33723432; PMCID: PMC8159895.
    Citations: 3     Fields:    Translation:HumansCells
  7. Latorre-Muro P, O'Malley KE, Bennett CF, Perry EA, Balsa E, Tavares CDJ, Jedrychowski M, Gygi SP, Puigserver P. A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation. Cell Metab. 2021 03 02; 33(3):598-614.e7. PMID: 33592173; PMCID: PMC7962155.
    Citations: 10     Fields:    Translation:AnimalsCells
  8. Perry EA, Bennett CF, Luo C, Balsa E, Jedrychowski M, O'Malley KE, Latorre-Muro P, Ladley RP, Reda K, Wright PM, Gygi SP, Myers AG, Puigserver P. Tetracyclines promote survival and fitness in mitochondrial disease models. Nat Metab. 2021 01; 3(1):33-42. PMID: 33462515; PMCID: PMC7856165.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  9. Lin H, Sharabi K, Lin L, Ruiz C, Zhu D, Cameron MD, Novick SJ, Griffin PR, Puigserver P, Kamenecka TM. Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production. J Med Chem. 2021 01 28; 64(2):980-990. PMID: 33434430; PMCID: PMC7869975.
    Citations: 1     Fields:    Translation:AnimalsCells
  10. Tavares CDJ, Aigner S, Sharabi K, Sathe S, Mutlu B, Yeo GW, Puigserver P. Transcriptome-wide analysis of PGC-1a-binding RNAs identifies genes linked to glucagon metabolic action. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22204-22213. PMID: 32848060.
    Citations: 6     Fields:    Translation:AnimalsCells
  11. Mutlu B, Puigserver P. GCN5 acetyltransferase in cellular energetic and metabolic processes. Biochim Biophys Acta Gene Regul Mech. 2021 02; 1864(2):194626. PMID: 32827753; PMCID: PMC7854474.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  12. Luo C, Liang J, Sharabi K, Hatting M, Perry EA, Tavares CDJ, Goyal L, Srivastava A, Bilodeau M, Zhu AX, Sicinski P, Puigserver P. Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency. Cancer Res. 2020 08 15; 80(16):3215-3221. PMID: 32606000; PMCID: PMC7442681.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Balsa E, Perry EA, Bennett CF, Jedrychowski M, Gygi SP, Doench JG, Puigserver P. Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death. Nat Commun. 2020 06 01; 11(1):2714. PMID: 32483148.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  14. Luo C, Balsa E, Perry EA, Liang J, Tavares CD, Vazquez F, Widlund HR, Puigserver P. H3K27me3-mediated PGC1a gene silencing promotes melanoma invasion through WNT5A and YAP. J Clin Invest. 2020 02 03; 130(2):853-862. PMID: 31929186; PMCID: PMC6994149.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  15. Cruces-Sande M, Arcones AC, Vila-Bedmar R, Val-Blasco A, Sharabi K, Díaz-Rodríguez D, Puigserver P, Mayor F, Murga C. Autophagy mediates hepatic GRK2 degradation to facilitate glucagon-induced metabolic adaptation to fasting. FASEB J. 2020 01; 34(1):399-409. PMID: 31914606.
    Citations: 3     Fields:    Translation:AnimalsCells
  16. Sharabi K, Tavares CDJ, Puigserver P. Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives. Curr Diab Rep. 2019 09 07; 19(10):98. PMID: 31494755; PMCID: PMC7050202.
    Citations: 3     Fields:    Translation:Humans
  17. Balsa E, Soustek MS, Thomas A, Cogliati S, García-Poyatos C, Martín-García E, Jedrychowski M, Gygi SP, Enriquez JA, Puigserver P. ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2a Axis. Mol Cell. 2019 06 06; 74(5):877-890.e6. PMID: 31023583; PMCID: PMC6555668.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  18. Soustek MS, Balsa E, Barrow JJ, Jedrychowski M, Vogel R, Gygi SP, Puigserver P. Inhibition of the ER stress IRE1a inflammatory pathway protects against cell death in mitochondrial complex I mutant cells. Cell Death Dis. 2018 05 31; 9(6):658. PMID: 29855477; PMCID: PMC5981317.
    Citations: 13     Fields:    Translation:HumansCells
  19. Hatting M, Tavares CDJ, Sharabi K, Rines AK, Puigserver P. Insulin regulation of gluconeogenesis. Ann N Y Acad Sci. 2018 01; 1411(1):21-35. PMID: 28868790; PMCID: PMC5927596.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  20. Luo C, Balsa E, Thomas A, Hatting M, Jedrychowski M, Gygi SP, Widlund HR, Puigserver P. ERRa Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1a-Elevated Melanomas. Mol Cancer Res. 2017 10; 15(10):1366-1375. PMID: 28596418; PMCID: PMC5954239.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  21. Sharabi K, Lin H, Tavares CDJ, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P. Selective Chemical Inhibition of PGC-1a Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017 03 23; 169(1):148-160.e15. PMID: 28340340.
    Citations: 60     Fields:    Translation:AnimalsCells
  22. Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017 03 09; 543(7644):252-256. PMID: 28219080.
    Citations: 228     Fields:    Translation:HumansAnimalsCells
  23. Hatting M, Rines AK, Luo C, Tabata M, Sharabi K, Hall JA, Verdeguer F, Trautwein C, Puigserver P. Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting. Cell Metab. 2017 02 07; 25(2):428-437. PMID: 28089567; PMCID: PMC5299049.
    Citations: 14     Fields:    Translation:AnimalsCells
  24. Luo C, Widlund HR, Puigserver P. PGC-1 Coactivators: Shepherding the Mitochondrial Biogenesis of Tumors. Trends Cancer. 2016 10; 2(10):619-631. PMID: 28607951.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  25. Barrow JJ, Balsa E, Verdeguer F, Tavares CD, Soustek MS, Hollingsworth LR, Jedrychowski M, Vogel R, Paulo JA, Smeitink J, Gygi SP, Doench J, Root DE, Puigserver P. Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations. Mol Cell. 2016 10 06; 64(1):163-175. PMID: 27666594; PMCID: PMC5055448.
    Citations: 16     Fields:    Translation:HumansCells
  26. Luo C, Lim JH, Lee Y, Granter SR, Thomas A, Vazquez F, Widlund HR, Puigserver P. A PGC1a-mediated transcriptional axis suppresses melanoma metastasis. Nature. 2016 09 15; 537(7620):422-426. PMID: 27580028; PMCID: PMC5161587.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  27. Rines AK, Sharabi K, Tavares CD, Puigserver P. Targeting hepatic glucose metabolism in the treatment of type 2 diabetes. Nat Rev Drug Discov. 2016 11; 15(11):786-804. PMID: 27516169; PMCID: PMC5751421.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  28. Luo C, Puigserver P, Widlund HR. Breaking BRAF(V600E)-drug resistance by stressing mitochondria. Pigment Cell Melanoma Res. 2016 07; 29(4):401-3. PMID: 27135210.
    Citations: 3     Fields:    Translation:HumansCells
  29. Tavares CD, Sharabi K, Dominy JE, Lee Y, Isasa M, Orozco JM, Jedrychowski MP, Kamenecka TM, Griffin PR, Gygi SP, Puigserver P. The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1a Transcriptional Coactivator. J Biol Chem. 2016 May 13; 291(20):10635-45. PMID: 27022023.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  30. Luo C, Puigserver P. Stem cells: Dietary fat promotes intestinal dysregulation. Nature. 2016 Mar 03; 531(7592):42-3. PMID: 26935693.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  31. Lee G, Won HS, Lee YM, Choi JW, Oh TI, Jang JH, Choi DK, Lim BO, Kim YJ, Park JW, Puigserver P, Lim JH. Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1a Activation. Sci Rep. 2016 Jan 07; 6:18928. PMID: 26740011.
    Citations: 54     Fields:    Translation:HumansCells
  32. Balsa-Martinez E, Puigserver P. Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth. Mol Cell. 2015 Nov 19; 60(4):509-11. PMID: 26590709.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  33. Sharabi K, Tavares CD, Rines AK, Puigserver P. Molecular pathophysiology of hepatic glucose production. Mol Aspects Med. 2015 Dec; 46:21-33. PMID: 26549348; PMCID: PMC4674831.
    Citations: 71     Fields:    Translation:HumansCells
  34. Verdeguer F, Soustek MS, Hatting M, Blättler SM, McDonald D, Barrow JJ, Puigserver P. Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity. Mol Cell Biol. 2015 Oct 26; 36(1):184-96. PMID: 26503783; PMCID: PMC4702598.
    Citations: 13     Fields:    Translation:AnimalsCells
  35. Soustek MS, Puigserver P. Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity. EMBO J. 2015 Apr 15; 34(8):981-3. PMID: 25736377; PMCID: PMC4406646.
    Citations:    Fields:    Translation:HumansAnimalsCells
  36. Rines AK, Verdeguer F, Puigserver P. Adenosine activates thermogenic adipocytes. Cell Res. 2015 Feb; 25(2):155-6. PMID: 25449131; PMCID: PMC4650567.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  37. Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature. 2014 Jun 26; 510(7506):547-51. PMID: 24870244.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  38. Lim JH, Luo C, Vazquez F, Puigserver P. Targeting mitochondrial oxidative metabolism in melanoma causes metabolic compensation through glucose and glutamine utilization. Cancer Res. 2014 Jul 01; 74(13):3535-45. PMID: 24812272.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  39. Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10; 508(7495):258-62. PMID: 24717514; PMCID: PMC4107212.
    Citations: 195     Fields:    Translation:AnimalsCells
  40. Hall JA, Tabata M, Rodgers JT, Puigserver P. USP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy. Mol Endocrinol. 2014 Jun; 28(6):912-24. PMID: 24694308.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  41. Chow JD, Lawrence RT, Healy ME, Dominy JE, Liao JA, Breen DS, Byrne FL, Kenwood BM, Lackner C, Okutsu S, Mas VR, Caldwell SH, Tomsig JL, Cooney GJ, Puigserver PB, Turner N, James DE, Villén J, Hoehn KL. Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation. Mol Metab. 2014 Jul; 3(4):419-31. PMID: 24944901.
    Citations: 37     Fields:    
  42. Verdeguer F, Blättler SM, Cunningham JT, Hall JA, Chim H, Puigserver P. Decreased genetic dosage of hepatic Yin Yang 1 causes diabetic-like symptoms. Mol Endocrinol. 2014 Mar; 28(3):308-16. PMID: 24467246.
    Citations: 3     Fields:    Translation:AnimalsCells
  43. Tabata M, Rodgers JT, Hall JA, Lee Y, Jedrychowski MP, Gygi SP, Puigserver P. Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1a and MED1 complex. Diabetes. 2014 May; 63(5):1519-32. PMID: 24458359; PMCID: PMC3994960.
    Citations: 14     Fields:    Translation:AnimalsCells
  44. Dominy JE, Puigserver P. Mitochondrial biogenesis through activation of nuclear signaling proteins. Cold Spring Harb Perspect Biol. 2013 Jul 01; 5(7). PMID: 23818499.
    Citations: 91     Fields:    Translation:HumansCells
  45. Hall JA, Dominy JE, Lee Y, Puigserver P. The sirtuin family's role in aging and age-associated pathologies. J Clin Invest. 2013 Mar; 123(3):973-9. PMID: 23454760; PMCID: PMC3582122.
    Citations: 88     Fields:    Translation:HumansAnimals
  46. Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, Puigserver P. PGC1a expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell. 2013 Mar 18; 23(3):287-301. PMID: 23416000.
    Citations: 328     Fields:    Translation:HumansAnimalsCells
  47. Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P. Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1a complex. J Biol Chem. 2013 Mar 08; 288(10):7117-26. PMID: 23329830.
    Citations: 70     Fields:    Translation:AnimalsCells
  48. Dominy J, Puigserver P, Cantó C. In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity. Methods Mol Biol. 2013; 1077:217-37. PMID: 24014410.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  49. Dominy JE, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol Cell. 2012 Dec 28; 48(6):900-13. PMID: 23142079.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  50. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110. PMID: 23021218.
    Citations: 149     Fields:    Translation:AnimalsCells
  51. Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP. A metabolic prosurvival role for PML in breast cancer. J Clin Invest. 2012 Sep; 122(9):3088-100. PMID: 22886304; PMCID: PMC3433768.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  52. Blättler SM, Verdeguer F, Liesa M, Cunningham JT, Vogel RO, Chim H, Liu H, Romanino K, Shirihai OS, Vazquez F, Rüegg MA, Shi Y, Puigserver P. Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Mol Cell Biol. 2012 Aug; 32(16):3333-46. PMID: 22711985; PMCID: PMC3434543.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  53. Blättler SM, Cunningham JT, Verdeguer F, Chim H, Haas W, Liu H, Romanino K, Rüegg MA, Gygi SP, Shi Y, Puigserver P. Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metab. 2012 Apr 04; 15(4):505-17. PMID: 22482732.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  54. Dominy JE, Gerhart-Hines Z, Puigserver P. Nutrient-dependent acetylation controls basic regulatory metabolic switches and cellular reprogramming. Cold Spring Harb Symp Quant Biol. 2011; 76:203-9. PMID: 22371372.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  55. Dominy JE, Vazquez F, Puigserver P. Glycine decarboxylase cleaves a "malignant" metabolic path to promote tumor initiation. Cancer Cell. 2012 Feb 14; 21(2):143-5. PMID: 22340586.
    Citations: 2     Fields:    
  56. Gerhart-Hines Z, Dominy JE, Blättler SM, Jedrychowski MP, Banks AS, Lim JH, Chim H, Gygi SP, Puigserver P. The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Mol Cell. 2011 Dec 23; 44(6):851-63. PMID: 22195961.
    Citations: 158     Fields:    Translation:HumansAnimalsCells
  57. Romanino K, Mazelin L, Albert V, Conjard-Duplany A, Lin S, Bentzinger CF, Handschin C, Puigserver P, Zorzato F, Schaeffer L, Gangloff YG, Rüegg MA. Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20808-13. PMID: 22143799; PMCID: PMC3251091.
    Citations: 23     Fields:    Translation:AnimalsCells
  58. Bhalla K, Hwang BJ, Dewi RE, Ou L, Twaddel W, Fang HB, Vafai SB, Vazquez F, Puigserver P, Boros L, Girnun GD. PGC1a promotes tumor growth by inducing gene expression programs supporting lipogenesis. Cancer Res. 2011 Nov 01; 71(21):6888-98. PMID: 21914785.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  59. Kelly TJ, Souza AL, Clish CB, Puigserver P. A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol. 2011 Jul; 31(13):2696-706. PMID: 21555452.
    Citations: 95     Fields:    Translation:HumansCells
  60. Rodgers JT, Vogel RO, Puigserver P. Clk2 and B56ß mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt. Mol Cell. 2011 Feb 18; 41(4):471-9. PMID: 21329884; PMCID: PMC3060660.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  61. Dominy JE, Puigserver P. Nuclear FoxO1 inflames insulin resistance. EMBO J. 2010 Dec 15; 29(24):4068-9. PMID: 21157481.
    Citations: 3     Fields:    Translation:AnimalsCells
  62. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 01; 24(13):1403-17. PMID: 20595232.
    Citations: 170     Fields:    Translation:HumansAnimalsCells
  63. Rodgers JT, Haas W, Gygi SP, Puigserver P. Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Cell Metab. 2010 Jan; 11(1):23-34. PMID: 20074525; PMCID: PMC2807620.
    Citations: 65     Fields:    Translation:AnimalsCells
  64. Dominy JE, Lee Y, Gerhart-Hines Z, Puigserver P. Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5. Biochim Biophys Acta. 2010 Aug; 1804(8):1676-83. PMID: 20005308.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  65. Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med. 2009 Nov; 15(11):1307-11. PMID: 19838201.
    Citations: 144     Fields:    Translation:AnimalsCells
  66. Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature. 2009 Sep 03; 461(7260):109-13. PMID: 19693011.
    Citations: 478     Fields:    Translation:HumansCells
  67. Kelly TJ, Lerin C, Haas W, Gygi SP, Puigserver P. GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. J Biol Chem. 2009 Jul 24; 284(30):19945-52. PMID: 19491097.
    Citations: 64     Fields:    Translation:HumansCells
  68. Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009 Apr 23; 458(7241):1056-60. PMID: 19262508.
    Citations: 1222     Fields:    Translation:AnimalsCells
  69. Rodgers JT, Puigserver P. Insulin resistance: beta-arrestin development. Cell Res. 2009 Mar; 19(3):275-6. PMID: 19252509.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  70. Housley MP, Udeshi ND, Rodgers JT, Shabanowitz J, Puigserver P, Hunt DF, Hart GW. A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose. J Biol Chem. 2009 Feb 20; 284(8):5148-57. PMID: 19103600.
    Citations: 97     Fields:    Translation:HumansCells
  71. Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Commun. 2009 Jan 23; 378(4):836-41. PMID: 19071085.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  72. Coste A, Louet JF, Lagouge M, Lerin C, Antal MC, Meziane H, Schoonjans K, Puigserver P, O'Malley BW, Auwerx J. The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17187-92. PMID: 18957541; PMCID: PMC2579399.
    Citations: 93     Fields:    Translation:AnimalsCells
  73. Housley MP, Rodgers JT, Udeshi ND, Kelly TJ, Shabanowitz J, Hunt DF, Puigserver P, Hart GW. O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem. 2008 Jun 13; 283(24):16283-92. PMID: 18420577.
    Citations: 154     Fields:    Translation:HumansAnimals
  74. J. T. Rodgers, C. Lerin, Z. Gerhart-Hines and P. Puigserver. Metabolic Adaptations Through PGC-1α and SIRT1 Pathways. FEBS Letters. 2008; 582:46-53.
  75. Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature. 2007 Nov 29; 450(7170):736-40. PMID: 18046414.
    Citations: 645     Fields:    Translation:AnimalsCells
  76. Rodgers JT, Lerin C, Gerhart-Hines Z, Puigserver P. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett. 2008 Jan 09; 582(1):46-53. PMID: 18036349.
    Citations: 259     Fields:    Translation:AnimalsCells
  77. Rodgers JT, Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12861-6. PMID: 17646659; PMCID: PMC1937557.
    Citations: 266     Fields:    Translation:Animals
  78. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11; 26(13):3169-79. PMID: 17581637; PMCID: PMC1914106.
    Citations: 462     Fields:    Translation:HumansAnimalsCells
  79. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 2007 Apr 04; 26(7):1913-23. PMID: 17347648; PMCID: PMC1847661.
    Citations: 548     Fields:    Translation:AnimalsCells
  80. Rodgers JT, Puigserver P. Receptor feasts on sugar and cholesterol. Nat Med. 2007 Feb; 13(2):128-9. PMID: 17290267.
    Citations: 1     Fields:    Translation:HumansCells
  81. J.T. Rodgers and P. Puigserver. Fasting-Dependent Glucose and Lipid Metabolic Response through Hepatic SIRT1. Proc. Natl. Acad. Sci. USA. 2007; 104(31):12861-66.
  82. Z. Gerhart-Hines, J.T. Rodgers, O. Bare, C. Lerin, S.H. Kim, R. Mostoslavsky, F.W. Alt, Z. Wu and P. Puigserver. Metabolic Control of Mitochondrial Function and Fatty Acid Oxidation Through PGC-1α/SIRT1. EMBO J. 2007; 26:1913-1923.
  83. J.T. Cunningham, J.T. Rodgers, D. Arlow, F. Vazquez, V.K. Mootha and P. Puigserver. mTOR controls mitochondrial oxidative function through a YY1/PGC-1α complex. Nature. 2007; 450:736-740.
  84. P. Puigserver and C.R. Kahn. Mammalian Metabolism in Aging. Molecular Biology of Aging. Edited by L. Guarente, L. Partridge and D.C. Wallace. Cold Spring Harbor Monograph Series. 2007; 51.
  85. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15; 127(6):1109-22. PMID: 17112576.
    Citations: 1574     Fields:    Translation:HumansAnimalsCells
  86. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16; 444(7117):337-42. PMID: 17086191.
    Citations: 1596     Fields:    Translation:AnimalsCells
  87. Cha SH, Rodgers JT, Puigserver P, Chohnan S, Lane MD. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15410-5. PMID: 17030788; PMCID: PMC1622837.
    Citations: 17     Fields:    Translation:AnimalsCells
  88. Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006 Aug 04; 281(31):21745-21754. PMID: 16751189.
    Citations: 270     Fields:    Translation:HumansAnimalsCells
  89. Lerin C, Rodgers JT, Kalume DE, Kim SH, Pandey A, Puigserver P. GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab. 2006 Jun; 3(6):429-38. PMID: 16753578.
    Citations: 217     Fields:    Translation:HumansAnimalsCells
  90. Rodgers JT, Puigserver P. Certainly can't live without this: SIRT6. Cell Metab. 2006 Feb; 3(2):77-8. PMID: 16459306.
    Citations: 10     Fields:    Translation:AnimalsCells
  91. Puigserver P, Rodgers JT. Foxa2, a novel transcriptional regulator of insulin sensitivity. Nat Med. 2006 Jan; 12(1):38-9. PMID: 16397559.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  92. J. T. Rodgers and P. Puigserver. Certainly you can’t live without it: SIRT6. Cell Metabolism. 2006; 3(2):77-8.
  93. S.H. Cha, Rodgers J.T., Puigserver, P., Chohnan, S. and Lane, M.D. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1α. Proc. Natl. Acad. Sci. 2006; 103(42):15410-5.
  94. M. Lagouge, Argmann, C., Gerhart-Hines, Z., Meziane, H., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Lerin, C., Geny, B., Laakso, M., Puigserver, P., Auwerx, J. Resveratrol promotes mitochondrial biogenesis and protects against metabolic disease through activating SIRT1 and PGC-1α activity. Cell. 2006; 127(6):1109-22.
  95. Pere Puigserver, Joseph T. Rodgers, Jill Milne and Karl Normington. Modulators of cdc2-like kinases (CLKs) and methods of use thereof. 2005.
  96. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005 Mar 03; 434(7029):113-8. PMID: 15744310.
    Citations: 1370     Fields:    Translation:AnimalsCells
  97. Puigserver P. Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha. Int J Obes (Lond). 2005 Mar; 29 Suppl 1:S5-9. PMID: 15711583.
    Citations: 118     Fields:    Translation:HumansAnimalsCells
  98. J.T. Rodgers, C. Lerin, W. Haas, S.P. Gygi, B.M. Spiegelman and P.Puigserver. Nutrient Control of Gluconeogenesis Through PGC-1α/SIRT1 Deacetylase Complex. Nature. 2005; 434:113-8.
  99. P. Puigserver. Tissue-Specific Regulation of Metabolic Pathways Through the Transcriptional Coactivator PGC-1α. Int. J. Obes. Relat. Metab. Disord. 2005; 29:S5-9.
  100. Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6570-5. PMID: 15100410; PMCID: PMC404086.
    Citations: 289     Fields:    Translation:AnimalsCells
  101. Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol. 2004 Apr; 24(7):3057-67. PMID: 15024092.
    Citations: 236     Fields:    Translation:HumansAnimalsCells
  102. Fan M, Rhee J, St-Pierre J, Handschin C, Puigserver P, Lin J, Jäeger S, Erdjument-Bromage H, Tempst P, Spiegelman BM. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev. 2004 Feb 01; 18(3):278-89. PMID: 14744933; PMCID: PMC338281.
    Citations: 123     Fields:    Translation:AnimalsCells
  103. M. Fan, J. Rhee, J. St-Pierre, C. Handshin, P. Puigserver, J. Lin, S. Jaeger, H. Erdjument-Bromage, P. Tempst and B. M. Spiegelman. Suppression of Mitochondrial Respiration via p160 Myb Binding Protein Docking on PGC-1α: Modulation by p38 MAPK. Genes Dev. 2004; 18:278-289.
  104. V.K. Mootha, C. Handschin, D. Arlow, X. Xie, J. St Pierre, S. Sihag, W. Yang, D. Altshuler, P. Puigserver, N. Patterson, P.J. Willy, I.G. Schulman, R.A. Heyman, E.S. Lander, B.M. Spiegelman. ERRalpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc. Natl. Acad. Sci. USA. 2004; 101:6570-5.
  105. W. Cao, K.W. Daniel, J. Rabidoux, P. Puigserver, A.V. Medvedev, X. Bai, L.M. Floering, B.M. Spiegelman and S. Collins. p38 Mitogen-Activated Protein Kinase is the Central Regulator of cAMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene. Mol.Cell Biol. 2004; 24:3057-3067.
  106. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003 Jul; 34(3):267-73. PMID: 12808457.
    Citations: 3770     Fields:    Translation:HumansAnimalsCells
  107. Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell. 2003 Jul; 5(1):73-83. PMID: 12852853.
    Citations: 63     Fields:    Translation:AnimalsCells
  108. Lin J, Tarr PT, Yang R, Rhee J, Puigserver P, Newgard CB, Spiegelman BM. PGC-1beta in the regulation of hepatic glucose and energy metabolism. J Biol Chem. 2003 Aug 15; 278(33):30843-8. PMID: 12807885.
    Citations: 104     Fields:    Translation:AnimalsCells
  109. Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 2003 May 29; 423(6939):550-5. PMID: 12754525.
    Citations: 585     Fields:    Translation:AnimalsCells
  110. Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, Spiegelman BM. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4012-7. PMID: 12651943; PMCID: PMC153039.
    Citations: 231     Fields:    Translation:AnimalsCells
  111. Puigserver P, Spiegelman BM. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev. 2003 Feb; 24(1):78-90. PMID: 12588810.
    Citations: 717     Fields:    Translation:HumansAnimalsCells
  112. Tritos NA, Mastaitis JW, Kokkotou EG, Puigserver P, Spiegelman BM, Maratos-Flier E. Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain. Brain Res. 2003 Jan 31; 961(2):255-60. PMID: 12531492.
    Citations: 15     Fields:    Translation:Animals
  113. J. Cliff Yoon, G. Xu, J.T. Deeny, S. Yang, J. Rhee, P. Puigserver, R. Yang, C. Zhang, B.B. Lowell, P.O. Berggren, C.B. Newgard, S. Bonner-Weir, G. Weir and B. M. Spiegelman. Suppression of β-Cell Energy Metabolism and Insulin release by PGC-1α. Dev. Cell. 2003; 5:73-83.
  114. J. Rhee, Y. Inoue, J.C. Yoon, P. Puigserver, M. Fan, F.J. Gonzalez, B.M. Spiegelman. Regulation of hepatic fasting response by PPARgamma coactivator-1 alpha (PGC-1): Requirement for hepatocyte nuclear factor 4 alpha in gluconeogenesis. Proc. Natl. Acad. Sci. USA. 2003; 100:4012-7.
  115. B.M. Spiegelman and P. Puigserver. PGC-1α: Metabolic Regulator and Transcriptional Coactivator. Endocr. Rev. 2003; 24(1):78-90.
  116. P. Puigserver, J. Rhee, J. Donovan, C.J. Walkey, J.C. Yoon, F. Oriente, Y. Kitamura, J. Altomonte, H. Dong, D. Accili and B.M. Spiegelman. Insulin-Regulated Hepatic Gluconeogenesis Through FOXO1/PGC-1α Interaction. Nature. 2003; 423:550-5.
  117. Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature. 2002 Aug 15; 418(6899):797-801. PMID: 12181572.
    Citations: 1007     Fields:    Translation:AnimalsCells
  118. J. Lin, P. Puigserver, J. Donovan, P. Tarr and B.M. Spiegelman. PGC-1β: A novel transcription coactivator associated with host cell factor. J. Biol. Chem. 2002; 277:1645-1648.
  119. J. Lin, H. Wu, P. Tarr, C.Y. Zhang, Z. Wu, O. Boss, L.F. Michael, P. Puigserver, E. Isotani, E. N. Olson, B. Lowell, R. Bassel-Duby and B.M. Spiegelman. Transcriptional Co-activator PGC-1α drives the formation of slow-twitch muscle fibers. Nature. 2002; 418:797-801.
  120. Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem. 2002 Jan 18; 277(3):1645-8. PMID: 11733490.
    Citations: 209     Fields:    Translation:AnimalsCells
  121. Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell. 2001 Nov; 8(5):971-82. PMID: 11741533.
    Citations: 295     Fields:    Translation:HumansAnimalsCells
  122. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):131-8. PMID: 11557972.
    Citations: 687     Fields:    Translation:AnimalsCells
  123. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):179-83. PMID: 11557984.
    Citations: 572     Fields:    Translation:HumansAnimalsCells
  124. Michael LF, Wu Z, Cheatham RB, Puigserver P, Adelmant G, Lehman JJ, Kelly DP, Spiegelman BM. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3820-5. PMID: 11274399; PMCID: PMC31136.
    Citations: 236     Fields:    Translation:AnimalsCells
  125. P. Puigserver, ,J. Rhee, J. Lin, Z. Wu, J.C. Yoon, C. Zhang, S. Krauss, V. Mootha. B.B. Lowell and B. M. Spiegelman. Cytokine-Activation of Energy Expenditure through p38 MAP kinase phosphorylation of the PPARγ coactivator (PGC-1). Mol. Cell. 2001; 8:971-982.
  126. L.F. Michael, Z. Wu, R.B. Cheatham, P. Puigserver, G. Adelmant, J.J. Lehman, D.P. Kelly, and B.M. Spiegelman. Restoration of Insulin-Sensitive Glucose Transporter (GLUT-4) Gene Expression in Muscle Cells by the Transcriptional Coactivator PGC-1. Proc. Natl. Acad. Sci. 2001; 98:3820-3825.
  127. S. Herzig, F. Long, U. Jhala, S. Hedrick, R. Quinn, A. Bauer, D. Rudolph, G. Schutz, J.C. Yoon, P. Puigserver, B.M. Spiegelman, and M. Montminy. CREB Regulates Hepatic Gluconeogenesis via the Co-activator PGC-1. Nature. 2001; 413:179-183.
  128. Spiegelman BM, Puigserver P, Wu Z. Regulation of adipogenesis and energy balance by PPARgamma and PGC-1. Int J Obes Relat Metab Disord. 2000 Nov; 24 Suppl 4:S8-10. PMID: 11126248.
    Citations: 38     Fields:    Translation:HumansCells
  129. Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM. Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol Cell. 2000 Aug; 6(2):307-16. PMID: 10983978.
    Citations: 150     Fields:    Translation:HumansAnimalsCells
  130. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes Dev. 2000 Jun 01; 14(11):1293-307. PMID: 10837022.
    Citations: 570     Fields:    Translation:HumansAnimalsCells
  131. Tcherepanova I, Puigserver P, Norris JD, Spiegelman BM, McDonnell DP. Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. J Biol Chem. 2000 May 26; 275(21):16302-8. PMID: 10748020.
    Citations: 75     Fields:    Translation:HumansCells
  132. B. M. Spiegelman, P. Puigserver, Z. Wu. Regulation of adipogenesis and energy balance by PPARγ and PGC-1. Int. J. Obes. Relat. Metab. Disord. 2000; 24(4):S8-10.
  133. Wu Z, Puigserver P, Spiegelman BM. Transcriptional activation of adipogenesis. Curr Opin Cell Biol. 1999 Dec; 11(6):689-94. PMID: 10600710.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  134. Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM. Activation of PPARgamma coactivator-1 through transcription factor docking. Science. 1999 Nov 12; 286(5443):1368-71. PMID: 10558993.
    Citations: 238     Fields:    Translation:AnimalsCells
  135. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 1999 Jul 09; 98(1):115-24. PMID: 10412986.
    Citations: 1522     Fields:    Translation:AnimalsCells
  136. Serra F, Bonet ML, Puigserver P, Oliver J, Palou A. Stimulation of uncoupling protein 1 expression in brown adipocytes by naturally occurring carotenoids. Int J Obes Relat Metab Disord. 1999 Jun; 23(6):650-5. PMID: 10411240.
    Citations: 14     Fields:    Translation:AnimalsCells
  137. B.M. Spiegelman, G. Castillo, S. Hauser and P. Puigserver. Regulation of energy balance by PPARγ and its coactivators. Progress in Obesity Research. Edited by B. Guy-Grand and G. Ailhaud. 1999; 39-46.
  138. F. Serra, M.L. Bonet, P. Puigserver, J. Oliver, A. Palou. Stimulation of uncoupling protein 1 expression in brown adipocyte by naturally occurring carotenoids. Int. J. Obes. Relat. Metab. Disord. 1999; 23:650-5.
  139. P. Puigserver, G. Adelmant, Z. Wu, M. Fan, J. Xu, B. O’Malley, B.M. Spiegelman. Activation of PPARγ Coactivator (PGC-1) Through Transcription Factor Docking. Science. 1999; 286(5443):1368-71.
  140. Picó C, Puigserver P, Oliver P, Palou A. 2-Methoxyestradiol, an endogenous metabolite of 17beta-estradiol, inhibits adipocyte proliferation. Mol Cell Biochem. 1998 Dec; 189(1-2):1-7. PMID: 9879647.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  141. Puigserver P, Ribot J, Serra F, Gianotti M, Bonet ML, Nadal-Ginard B, Palou A. Involvement of the retinoblastoma protein in brown and white adipocyte cell differentiation: functional and physical association with the adipogenic transcription factor C/EBPalpha. Eur J Cell Biol. 1998 Oct; 77(2):117-23. PMID: 9840461.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  142. Bruce M. Spiegelman, Pere Puigserver and Zhidan Wu. PGC-1alpha. Novel Brown Fat PPARgamma coactivator. 1998.
  143. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998 Mar 20; 92(6):829-39. PMID: 9529258.
    Citations: 1373     Fields:    Translation:AnimalsCells
  144. C. Pico, P. Puigserver, P. Oliver, A. Palou. 2-Methoxyoestradiol, an endogenous metabolite of 17-β-estradiol, inhibits adipocyte proliferation. Mol. Cell. Biochem. 1998; 189:1-7.
  145. Garcia-Palmer FJ, Pericas J, Matamala JC, Puigserver P, Bonet ML, Palou A, Gianotti M. Diminished response to food deprivation of the rat brown adipose tissue mitochondrial uncoupling system with age. Biochem Mol Biol Int. 1997 Sep; 42(6):1151-61. PMID: 9305533.
    Citations:    Fields:    Translation:AnimalsCells
  146. Bonet ML, Puigserver P, Serra F, Ribot J, Vázquez F, Pico C, Palou A. Retinoic acid modulates retinoid X receptor alpha and retinoic acid receptor alpha levels of cultured brown adipocytes. FEBS Lett. 1997 Apr 07; 406(1-2):196-200. PMID: 9109417.
    Citations: 9     Fields:    Translation:AnimalsCells
  147. M.L. Bonet, P. Puigserver, F. Serra, F. Vazquez, C. Pico, A. Palou. Retinoic acid modulates RARα and RXRα levels in cultured brown adipocytes. FEBS Lett. 1997; 406:196-200.
  148. F.J. Garcia-Palmer, J. Pericas, J.C. Matamala, P. Puigserver, M.L. Bonet, A Palou, M. Gianotti. Diminished response to food deprivation of the rat brown adipose tissue mitochondrial uncoupling system with age. Biochem. Mol. Biol. Int. 1997; 42:1151-1161.
  149. Puigserver P, Vázquez F, Bonet ML, Picó C, Palou A. In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid. Biochem J. 1996 Aug 01; 317 ( Pt 3):827-33. PMID: 8760369; PMCID: PMC1217559.
    Citations: 32     Fields:    Translation:AnimalsCells
  150. Puigserver P, Picó C, Stock MJ, Palou A. Effect of selective beta-adrenoceptor stimulation on UCP synthesis in primary cultures of brown adipocytes. Mol Cell Endocrinol. 1996 Mar 01; 117(1):7-16. PMID: 8734469.
    Citations: 8     Fields:    Translation:AnimalsCells
  151. P. Puigserver, C. Pico, M.J. Stock, A. Palou. Effect of selective ß-adrenoceptor stimulation on UCP expression in primary cultures of brown adipocytes. Mol. Cell Endocrinol. 1996; 117:7-16.
  152. P. Puigserver, F. Vazquez, M.L. Bonet, C. Pico, A. Palou. In vitro an in vivo induction of the uncoupling protein thermogenin by retinoids. Biochem. J. 1996; 317:827-833.
  153. Moreno M, Puigserver P, Llull J, Gianotti M, Lanni A, Goglia F, Palou A. Cold exposure induces different uncoupling-protein thermogenin masking/unmasking processes in brown adipose tissue depending on mitochondrial subtypes. Biochem J. 1994 Jun 01; 300 ( Pt 2):463-8. PMID: 8002952; PMCID: PMC1138185.
    Citations: 7     Fields:    Translation:AnimalsCells
  154. Puigserver P, Palou A, Gianotti M. Dietary regulation of fasting-induced mitochondrial protein degradation in adult rat brown adipose tissue. Biochem Int. 1992 Sep; 27(6):1037-46. PMID: 1332718.
    Citations:    Fields:    Translation:AnimalsCells
  155. Puigserver P, Herron D, Gianotti M, Palou A, Cannon B, Nedergaard J. Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool. Biochem J. 1992 Jun 01; 284 ( Pt 2):393-8. PMID: 1599423; PMCID: PMC1132651.
    Citations: 34     Fields:    Translation:AnimalsCells
  156. Puigserver P, Gianotti M, Palou A. Impaired starvation-induced loss of mitochondrial protein in the brown adipose tissue of dietary obese rats. Int J Obes Relat Metab Disord. 1992 Apr; 16(4):255-61. PMID: 1318279.
    Citations: 3     Fields:    Translation:AnimalsCells
  157. P. Puigserver, A. Palou, M. Gianotti. Impaired starvation-induced loss of mitochondrial protein in the brown adipose tissue of dietary obese rats. Int. J. Obes. 1992; 16:255-261.
  158. Pere Puigserver. Adrenergic stimulation and obesity status regulate induction and degradation of the thermogenic uncoupling protein in brown adipose in-vitro and in-vivo. 1992.
  159. Puigserver P, Lladó I, Palou A, Gianotti M. Evidence for masking of brown adipose tissue mitochondrial GDP-binding sites in response to fasting in rats made obese by dietary manipulation. Effects of reversion to standard diet. Biochem J. 1991 Oct 15; 279 ( Pt 2):575-9. PMID: 1953651; PMCID: PMC1151642.
    Citations: 9     Fields:    Translation:AnimalsCells
  160. J. Nedergaard, M. Néchad, S. Rehnmark, D. Herron, A. Jacobsson, P. Kuusela, P. Puigserver, J. Houstek, G. Bronnikov and B. Cannon. Adrenergic regulation of differentiation and proliferation in brown adipocyte cultures. Obesity in Europe. Edited by G. Ailhaud et al. 1991; 355-361.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.