Harvard Catalyst Profiles

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Paul Brian Dieffenbach, M.D.

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  1. K08HL143197 (DIEFFENBACH, PAUL BRIAN) Jul 15, 2018 - Jun 30, 2023
    NIH
    YAP/TAZ-mediated Mechanotransduction in Pulmonary Hypertension Pathogenesis
    Role: Principal Investigator
  2. F32HL131228 (DIEFFENBACH, PAUL BRIAN) Feb 4, 2016 - Feb 3, 2018
    NIH
    Pulmonary Vascular Cellular Response to Pathologic Matrix Stiffness in Pulmonary Arterial Hypertension
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shen Y, Goncharov DA, Pena A, Baust J, Chavez Barragan A, Ray A, Rode A, Bachman TN, Chang B, Jiang L, Dieffenbach P, Fredenburgh LE, Rojas M, DeLisser H, Mora AL, Kudryashova TV, Goncharova EA. Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension. Sci Signal. 2022 12 06; 15(763):eabn2743. PMID: 36473049; PMCID: PMC9869933.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Train SE, Dieffenbach PB, Massaro AF, Devlin JW. Sedation, Neuromuscular Blockade, and Mortality in Acute Respiratory Distress Syndrome: Important Questions Remain. Crit Care Med. 2022 01 01; 50(1):e89-e90. PMID: 34914654.
    Citations:    Fields:    Translation:Humans
  3. Dieffenbach PB, Mallarino Haeger C, Rehman R, Corcoran AM, Coronata AMF, Vellarikkal SK, Chrobak I, Waxman AB, Vitali SH, Sholl LM, Padera RF, Lagares D, Polverino F, Owen CA, Fredenburgh LE. A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature. Am J Respir Crit Care Med. 2021 12 15; 204(12):1433-1451. PMID: 34550870; PMCID: PMC8865706.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  4. Dieffenbach PB, Aravamudhan A, Fredenburgh LE, Tschumperlin DJ. The Mechanobiology of Vascular Remodeling in the Aging Lung. Physiology (Bethesda). 2022 01 01; 37(1):28-38. PMID: 34514871; PMCID: PMC8742727.
    Citations: 1     Fields:    Translation:Humans
  5. Kuo YW, Harris RS, Hess DR, Dieffenbach PB, Choi AMK, Fredenburgh LE, Winkler T. Endogenous Carbon Monoxide Production and Diffusing Capacity of the Lung for Carbon Monoxide in Sepsis-Induced Acute Respiratory Distress Syndrome. Crit Care Explor. 2020 Dec; 2(12):e0286. PMID: 33283194.
    Citations: 1     
  6. Rehman R, Vijayakumar VE, Jaiswal A, Jain V, Mukherjee S, Vellarikkal SK, Dieffenbach PB, Fredenburgh LE, Prakash YS, Ghosh B, Agrawal A, Mabalirajan U. Noncanonical role for Ku70/80 in the prevention of allergic airway inflammation via maintenance of airway epithelial cell organelle homeostasis. Am J Physiol Lung Cell Mol Physiol. 2020 10 01; 319(4):L728-L741. PMID: 32877223.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Mason SE, Dieffenbach PB, Englert JA, Rogers AA, Massaro AF, Fredenburgh LE, Higuera A, Pinilla-Vera M, Vilas M, San Jose Estepar R, Washko GR, Baron RM, Ash SY. Semi-quantitative visual assessment of chest radiography is associated with clinical outcomes in critically ill patients. Respir Res. 2019 Oct 12; 20(1):218. PMID: 31606045; PMCID: PMC6790038.
    Citations: 7     Fields:    Translation:Humans
  8. Hudalla H, Michael Z, Christodoulou N, Willis GR, Fernandez-Gonzalez A, Filatava EJ, Dieffenbach P, Fredenburgh LE, Stearman RS, Geraci MW, Kourembanas S, Christou H. Carbonic Anhydrase Inhibition Ameliorates Inflammation and Experimental Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019 10; 61(4):512-524. PMID: 30951642; PMCID: PMC6775956.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  9. Atri D, Shappell C, Dieffenbach PB, Sun YP. A Tight Squeeze: Focal Tamponade and Obstructive Shock From Esophageal Stenting. JACC Case Rep. 2019 Jun; 1(1):70-72. PMID: 34316748.
    Citations:    
  10. Englert JA, Cho MH, Lamb AE, Shumyatcher M, Barragan-Bradford D, Basil MC, Higuera A, Isabelle C, Vera MP, Dieffenbach PB, Fredenburgh LE, Kang JB, Bhatt AS, Antin JH, Ho VT, Soiffer RJ, Howrylak JA, Himes BE, Baron RM. Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation. Respir Res. 2019 Jan 21; 20(1):15. PMID: 30665420.
    Citations: 11     Fields:    Translation:HumansCells
  11. Fredenburgh LE, Perrella MA, Barragan-Bradford D, Hess DR, Peters E, Welty-Wolf KE, Kraft BD, Harris RS, Maurer R, Nakahira K, Oromendia C, Davies JD, Higuera A, Schiffer KT, Englert JA, Dieffenbach PB, Berlin DA, Lagambina S, Bouthot M, Sullivan AI, Nuccio PF, Kone MT, Malik MJ, Porras MAP, Finkelsztein E, Winkler T, Hurwitz S, Serhan CN, Piantadosi CA, Baron RM, Thompson BT, Choi AM. A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. JCI Insight. 2018 12 06; 3(23). PMID: 30518685; PMCID: PMC6328240.
    Citations: 38     Fields:    Translation:HumansCTClinical Trials
  12. Dieffenbach PB, Maracle M, Tschumperlin DJ, Fredenburgh LE. Mechanobiological Feedback in Pulmonary Vascular Disease. Front Physiol. 2018; 9:951. PMID: 30090065; PMCID: PMC6068271.
    Citations: 15     
  13. Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 06 13; 10(445). PMID: 29899023.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  14. Dieffenbach PB, Haeger CM, Coronata AMF, Choi KM, Varelas X, Tschumperlin DJ, Fredenburgh LE. Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 01; 313(3):L628-L647. PMID: 28642262; PMCID: PMC5625262.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  15. Putman RK, Hunninghake GM, Dieffenbach PB, Barragan-Bradford D, Serhan K, Adams U, Hatabu H, Nishino M, Padera RF, Fredenburgh LE, Baron RM, Englert JA. Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017 01 01; 195(1):138-141. PMID: 28035861; PMCID: PMC5214919.
    Citations: 19     Fields:    Translation:Humans
  16. Liu F, Haeger CM, Dieffenbach PB, Sicard D, Chrobak I, Coronata AM, Suárez Velandia MM, Vitali S, Colas RA, Norris PC, Marinkovic A, Liu X, Ma J, Rose CD, Lee SJ, Comhair SA, Erzurum SC, McDonald JD, Serhan CN, Walsh SR, Tschumperlin DJ, Fredenburgh LE. Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension. JCI Insight. 2016 Jun 02; 1(8). PMID: 27347562.
    Citations: 39     Fields:    
  17. Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY. Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. Cell Rep. 2015 Nov 03; 13(5):1016-32. PMID: 26565914.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  18. Park SK, Nguyen MD, Fischer A, Luke MP, Affar el B, Dieffenbach PB, Tseng HC, Shi Y, Tsai LH. Par-4 links dopamine signaling and depression. Cell. 2005 Jul 29; 122(2):275-87. PMID: 16051151.
    Citations: 47     Fields:    Translation:AnimalsCells
  19. Marko NF, Dieffenbach PB, Yan G, Ceryak S, Howell RW, McCaffrey TA, Hu VW. Does metabolic radiolabeling stimulate the stress response? Gene expression profiling reveals differential cellular responses to internal beta vs. external gamma radiation. FASEB J. 2003 Aug; 17(11):1470-86. PMID: 12890701.
    Citations: 8     Fields:    Translation:HumansCells
  20. Hu VW, Heikka DS, Dieffenbach PB, Ha L. Metabolic radiolabeling: experimental tool or Trojan horse? (35)S-Methionine induces DNA fragmentation and p53-dependent ROS production. FASEB J. 2001 Jul; 15(9):1562-8. PMID: 11427488.
    Citations: 10     Fields:    Translation:AnimalsCells
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© 2023 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.