Harvard Catalyst Profiles

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Xikun Han, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Han X, Steven K, Qassim A, Marshall HN, Bean C, Tremeer M, An J, Siggs OM, Gharahkhani P, Craig JE, Hewitt AW, Trzaskowski M, MacGregor S. Automated AI labeling of optic nerve head enables insights into cross-ancestry glaucoma risk and genetic discovery in >280,000 images from UKB and CLSA. Am J Hum Genet. 2021 07 01; 108(7):1204-1216. PMID: 34077762.
    Citations: 2     Fields:    Translation:Humans
  2. Han X, Lee SS, Ingold N, McArdle N, Khawaja AP, MacGregor S, Mackey DA. Associations of sleep apnoea with glaucoma and age-related macular degeneration: an analysis in the United Kingdom Biobank and the Canadian Longitudinal Study on Aging. BMC Med. 2021 05 11; 19(1):104. PMID: 33971878.
    Citations:    Fields:    
  3. Han X, Ong JS, Hewitt AW, Gharahkhani P, MacGregor S. The effects of eight serum lipid biomarkers on age-related macular degeneration risk: a Mendelian randomization study. Int J Epidemiol. 2021 03 03; 50(1):325-336. PMID: 33211829.
    Citations: 1     Fields:    Translation:Humans
  4. Gharahkhani P, Jorgenson E, Hysi P, Khawaja AP, Pendergrass S, Han X, Ong JS, Hewitt AW, Segrè AV, Rouhana JM, Hamel AR, Igo RP, Choquet H, Qassim A, Josyula NS, Cooke Bailey JN, Bonnemaijer PWM, Iglesias A, Siggs OM, Young TL, Vitart V, Thiadens AAHJ, Karjalainen J, Uebe S, Melles RB, Nair KS, Luben R, Simcoe M, Amersinghe N, Cree AJ, Hohn R, Poplawski A, Chen LJ, Rong SS, Aung T, Vithana EN, Tamiya G, Shiga Y, Yamamoto M, Nakazawa T, Currant H, Birney E, Wang X, Auton A, Lupton MK, Martin NG, Ashaye A, Olawoye O, Williams SE, Akafo S, Ramsay M, Hashimoto K, Kamatani Y, Akiyama M, Momozawa Y, Foster PJ, Khaw PT, Morgan JE, Strouthidis NG, Kraft P, Kang JH, Pang CP, Pasutto F, Mitchell P, Lotery AJ, Palotie A, van Duijn C, Haines JL, Hammond C, Pasquale LR, Klaver CCW, Hauser M, Khor CC, Mackey DA, Kubo M, Cheng CY, Craig JE, MacGregor S, Wiggs JL. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat Commun. 2021 02 24; 12(1):1258. PMID: 33627673.
    Citations: 9     Fields:    Translation:Humans
  5. Han X, Hewitt AW, MacGregor S. Predicting the Future of Genetic Risk Profiling of Glaucoma: A Narrative Review. JAMA Ophthalmol. 2021 02 01; 139(2):224-231. PMID: 33331888.
    Citations:    Fields:    Translation:Humans
  6. Ong JS, Dixon-Suen SC, Han X, An J, Liyanage U, Dusingize JC, Schumacher J, Gockel I, Böhmer A, Jankowski J, Palles C, O'Mara T, Spurdle A, Law MH, Iles MM, Pharoah P, Berchuck A, Zheng W, Thrift AP, Olsen C, Neale RE, Gharahkhani P, Webb PM, MacGregor S. A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization. Nat Commun. 2021 01 11; 12(1):246. PMID: 33431812.
    Citations: 2     Fields:    Translation:Humans
  7. Zhu D, Mishra SR, Han X, Santo K. Social distancing in Latin America during the COVID-19 pandemic: an analysis using the Stringency Index and Google Community Mobility Reports. J Travel Med. 2020 12 23; 27(8). PMID: 32729931.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  8. Qassim A, Mullany S, Awadalla MS, Hassall MM, Nguyen T, Marshall H, Kolovos A, Schulz AM, Han X, Gharahkhani P, Galanopoulos A, Agar A, Healey PR, Hewitt AW, Landers J, Casson RJ, Graham SL, MacGregor S, Souzeau E, Siggs OM, Craig JE. A Polygenic Risk Score Predicts Intraocular Pressure Readings Outside Office Hours and Early Morning Spikes as Measured by Home Tonometry. Ophthalmol Glaucoma. 2021 Jul-Aug; 4(4):411-420. PMID: 33316431.
    Citations: 1     
  9. Han X, Ong JS, An J, Craig JE, Gharahkhani P, Hewitt AW, MacGregor S. Association of Myopia and Intraocular Pressure With Retinal Detachment in European Descent Participants of the UK Biobank Cohort: A Mendelian Randomization Study. JAMA Ophthalmol. 2020 06 01; 138(6):671-678. PMID: 32352494.
    Citations: 1     Fields:    Translation:Humans
  10. Han X, Gharahkhani P, Mitchell P, Liew G, Hewitt AW, MacGregor S. Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration. J Hum Genet. 2020 Aug; 65(8):657-665. PMID: 32277175.
    Citations: 12     Fields:    Translation:Humans
  11. Craig JE, Han X, Qassim A, Hassall M, Cooke Bailey JN, Kinzy TG, Khawaja AP, An J, Marshall H, Gharahkhani P, Igo RP, Graham SL, Healey PR, Ong JS, Zhou T, Siggs O, Law MH, Souzeau E, Ridge B, Hysi PG, Burdon KP, Mills RA, Landers J, Ruddle JB, Agar A, Galanopoulos A, White AJR, Willoughby CE, Andrew NH, Best S, Vincent AL, Goldberg I, Radford-Smith G, Martin NG, Montgomery GW, Vitart V, Hoehn R, Wojciechowski R, Jonas JB, Aung T, Pasquale LR, Cree AJ, Sivaprasad S, Vallabh NA, Viswanathan AC, Pasutto F, Haines JL, Klaver CCW, van Duijn CM, Casson RJ, Foster PJ, Khaw PT, Hammond CJ, Mackey DA, Mitchell P, Lotery AJ, Wiggs JL, Hewitt AW, MacGregor S. Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression. Nat Genet. 2020 02; 52(2):160-166. PMID: 31959993.
    Citations: 27     Fields:    Translation:Humans
  12. Qassim A, Souzeau E, Siggs OM, Hassall MM, Han X, Griffiths HL, Frost NA, Vallabh NA, Kirwan JF, Menon G, Cree AJ, Galanopoulos A, Agar A, Healey PR, Graham SL, Landers J, Casson RJ, Gharahkhani P, Willoughby CE, Hewitt AW, Lotery AJ, MacGregor S, Craig JE. An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity. Ophthalmology. 2020 07; 127(7):901-907. PMID: 32081492.
    Citations: 3     Fields:    Translation:Humans
  13. Han X, Ong JS, An J, Hewitt AW, Gharahkhani P, MacGregor S. Using Mendelian randomization to evaluate the causal relationship between serum C-reactive protein levels and age-related macular degeneration. Eur J Epidemiol. 2020 Feb; 35(2):139-146. PMID: 31900758.
    Citations: 10     Fields:    Translation:Humans
  14. An J, Gharahkhani P, Law MH, Ong JS, Han X, Olsen CM, Neale RE, Lai J, Vaughan TL, Gockel I, Thieme R, Böhmer AC, Jankowski J, Fitzgerald RC, Schumacher J, Palles C, Whiteman DC, MacGregor S. Author Correction: Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases. Nat Commun. 2019 Dec 04; 10(1):5617. PMID: 31796739.
    Citations:    Fields:    
  15. Han X, Qassim A, An J, Marshall H, Zhou T, Ong JS, Hassall MM, Hysi PG, Foster PJ, Khaw PT, Mackey DA, Gharahkhani P, Khawaja AP, Hewitt AW, Craig JE, MacGregor S. Genome-wide association analysis of 95?549 individuals identifies novel loci and genes influencing optic disc morphology. Hum Mol Genet. 2019 11 01; 28(21):3680-3690. PMID: 31809533.
    Citations: 3     Fields:    Translation:Humans
  16. Ong JS, Law MH, An J, Han X, Gharahkhani P, Whiteman DC, Neale RE, MacGregor S. Association between coffee consumption and overall risk of being diagnosed with or dying from cancer among >300 000 UK Biobank participants in a large-scale Mendelian randomization study. Int J Epidemiol. 2019 10 01; 48(5):1447-1456. PMID: 31412118.
    Citations: 7     Fields:    Translation:Humans
  17. An J, Gharahkhani P, Law MH, Ong JS, Han X, Olsen CM, Neale RE, Lai J, Vaughan TL, Gockel I, Thieme R, Böhmer AC, Jankowski J, Fitzgerald RC, Schumacher J, Palles C, Whiteman DC, MacGregor S. Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases. Nat Commun. 2019 09 16; 10(1):4219. PMID: 31527586.
    Citations: 4     Fields:    Translation:Humans
  18. Liyanage UE, Law MH, Han X, An J, Ong JS, Gharahkhani P, Gordon S, Neale RE, Olsen CM, MacGregor S, Whiteman DC. Combined analysis of keratinocyte cancers identifies novel genome-wide loci. Hum Mol Genet. 2019 09 15; 28(18):3148-3160. PMID: 31174203.
    Citations: 10     Fields:    Translation:HumansCells
  19. Han X, Souzeau E, Ong JS, An J, Siggs OM, Burdon KP, Best S, Goldberg I, Healey PR, Graham SL, Ruddle JB, Mills RA, Landers J, Galanopoulos A, White AJR, Casson R, Mackey DA, Hewitt AW, Gharahkhani P, Craig JE, MacGregor S. Myocilin Gene Gln368Ter Variant Penetrance and Association With Glaucoma in Population-Based and Registry-Based Studies. JAMA Ophthalmol. 2019 01 01; 137(1):28-35. PMID: 30267046.
    Citations: 2     Fields:    Translation:Humans
  20. Gong X, Han X, Lu X, Chen J, Huang J, Kelly TN, Chen CS, He J, Gu D, Chen S. Association of Kir genes with blood pressure responses to dietary sodium intervention: the GenSalt study. Hypertens Res. 2018 Dec; 41(12):1045-1053. PMID: 30323262.
    Citations:    Fields:    Translation:Humans
  21. MacGregor S, Ong JS, An J, Han X, Zhou T, Siggs OM, Law MH, Souzeau E, Sharma S, Lynn DJ, Beesley J, Sheldrick B, Mills RA, Landers J, Ruddle JB, Graham SL, Healey PR, White AJR, Casson RJ, Best S, Grigg JR, Goldberg I, Powell JE, Whiteman DC, Radford-Smith GL, Martin NG, Montgomery GW, Burdon KP, Mackey DA, Gharahkhani P, Craig JE, Hewitt AW. Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma. Nat Genet. 2018 08; 50(8):1067-1071. PMID: 30054594.
    Citations: 45     Fields:    Translation:Humans
  22. Li L, Wang L, Li H, Han X, Chen S, Yang B, Hu Z, Zhu H, Cai C, Chen J, Li X, Huang J, Gu D. Characterization of LncRNA expression profile and identification of novel LncRNA biomarkers to diagnose coronary artery disease. Atherosclerosis. 2018 08; 275:359-367. PMID: 30015300.
    Citations: 24     Fields:    Translation:HumansCells
  23. Li H, Han X, Hu Z, Huang J, Chen J, Hixson JE, Rao DC, He J, Gu D, Chen S. Associations of NADPH oxidase-related genes with blood pressure changes and incident hypertension: The GenSalt Study. J Hum Hypertens. 2018 04; 32(4):287-293. PMID: 29463833.
    Citations: 6     Fields:    Translation:Humans
  24. Huang P, Yu Y, Han X, Yang Y. Efficacy of Short-term Dual Antiplatelet Therapy after Implantation of Second-generation Drug-eluting Stents: A Meta-analysis and Systematic Review. Chin Med Sci J. 2017 04 10; 32(1):1-12. PMID: 28399979.
    Citations:    Fields:    Translation:Humans
  25. Han X, Hu Z, Chen J, Huang J, Huang C, Liu F, Gu C, Yang X, Hixson JE, Lu X, Wang L, Liu DP, He J, Chen S, Gu D. Associations Between Genetic Variants of NADPH Oxidase-Related Genes and Blood Pressure Responses to Dietary Sodium Intervention: The GenSalt Study. Am J Hypertens. 2017 Apr 01; 30(4):427-434. PMID: 28200110.
    Citations: 6     Fields:    Translation:Humans
  26. Wang L, Li H, Yang B, Guo L, Han X, Li L, Li M, Huang J, Gu D. The Hypertension Risk Variant Rs820430 Functions as an Enhancer of SLC4A7. Am J Hypertens. 2017 Feb; 30(2):202-208. PMID: 27784683.
    Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
  27. Huang K, Liu F, Han X, Huang C, Huang J, Gu D, Yang X. Association of BMI with total mortality and recurrent stroke among stroke patients: A meta-analysis of cohort studies. Atherosclerosis. 2016 10; 253:94-101. PMID: 27596134.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.