Harvard Catalyst Profiles

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Veera Chandra Sekhar Reddy Chittepu, Ph.D.

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Available: 12/13/22, Expires: 04/30/25

Cancer immunotherapy has revolutionized cancer treatment, but is only moderately effective and associated with significant toxicity. Advances in targeted delivery technologies using nanotechnology and cell engineering approaches will be utilized in our lab to deliver chemicals, peptides, and biologics to and modify the tumor microenvironment (TME), boost anti-tumor immunity, decrease the toxicity and addresses some other drawbacks of treatments. We take this opportunity to train new or existing undergraduate or graduate students to learn and advance existing technologies to treat cancer. The proposed and available projects will assist students in gaining new molecular insights into cancer immunotherapy and later progressing in developing combination therapies, as well as using targeted delivery strategies to reach tumors and modify TME to boost anti-tumor immunity. The strategies taught to the student during his stay in our lab prepare him to apply techniques in general to understand cancer biology and the potential opportunity to translate findings from bench to clinic in the future. The student will have the opportunity to present his findings in meetings, conferences, and publish in peer-reviewed journals.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhu Z, Ma AH, Zhang H, Lin TY, Xue X, Farrukh H, Zhu S, Shi W, Yuan R, Cao Z, Chittepu VCSR, Prabhala R, Li Y, Lam KS, Pan CX. Phototherapy with Cancer-Specific Nanoporphyrin Potentiates Immunotherapy in Bladder Cancer. Clin Cancer Res. 2022 11 01; 28(21):4820-4831. PMID: 35921526; PMCID: PMC9633390.
    Citations:    Fields:    Translation:AnimalsCells
  2. Pan K, Farrukh H, Chittepu VCSR, Xu H, Pan CX, Zhu Z. CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy. J Exp Clin Cancer Res. 2022 Mar 31; 41(1):119. PMID: 35361234; PMCID: PMC8969382.
    Citations: 1     Fields:    Translation:HumansCells
  3. Zhu S, Ma AH, Zhu Z, Adib E, Rao T, Li N, Ni K, Chittepu VCSR, Prabhala R, Garisto Risco J, Kwiatkowski D, Mouw K, Sonpavde G, Cheng F, Pan CX. Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer. J Immunother Cancer. 2021 11; 9(11). PMID: 34725212; PMCID: PMC8562536.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  4. Kalhotra P, Chittepu VCSR, Osorio-Revilla G, Gallardo-Velazquez T. Field-Template, QSAR, Ensemble Molecular Docking, and 3D-RISM Solvation Studies Expose Potential of FDA-Approved Marine Drugs as SARS-CoVID-2 Main Protease Inhibitors. Molecules. 2021 Feb 10; 26(4). PMID: 33578831; PMCID: PMC7916619.
    Citations: 3     Fields:    Translation:HumansCells
  5. Kalhotra P, Chittepu VCSR, Osorio-Revilla G, Gallardo-Velazquez T. Phytochemicals in Garlic Extract Inhibit Therapeutic Enzyme DPP-4 and Induce Skeletal Muscle Cell Proliferation: A Possible Mechanism of Action to Benefit the Treatment of Diabetes Mellitus. Biomolecules. 2020 02 14; 10(2). PMID: 32075130.
    Citations: 7     Fields:    Translation:Animals
  6. Chittepu VCSR, Kalhotra P, Osorio-Gallardo T, Jiménez-Martínez C, Torre RRR, Gallardo-Velazquez T, Osorio-Revilla G. New Molecular Insights into the Inhibition of Dipeptidyl Peptidase-4 by Natural Cyclic Peptide Oxytocin. Molecules. 2019 Oct 28; 24(21). PMID: 31661941; PMCID: PMC6864445.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  7. Chittepu VCSR, Kalhotra P, Osorio-Gallardo T, Gallardo-Velázquez T, Osorio-Revilla G. Repurposing of FDA-Approved NSAIDs for DPP-4 Inhibition as an Alternative for Diabetes Mellitus Treatment: Computational and in Vitro Study. Pharmaceutics. 2019 May 17; 11(5). PMID: 31108878; PMCID: PMC6572294.
    Citations: 5     
  8. Kalhotra P, Chittepu VCSR, Osorio-Revilla G, Gallardo-Velázquez T. Discovery of Galangin as a Potential DPP-4 Inhibitor That Improves Insulin-Stimulated Skeletal Muscle Glucose Uptake: A Combinational Therapy for Diabetes. Int J Mol Sci. 2019 Mar 11; 20(5). PMID: 30862104; PMCID: PMC6429117.
    Citations: 8     Fields:    Translation:AnimalsCells
  9. Chittepu VCSR, Kalhotra P, Gallardo-Velázquez T, Robles-de la Torre RR, Osorio-Revilla G. Designed Functional Dispersion for Insulin Protection from Pepsin Degradation and Skeletal Muscle Cell Proliferation: In Silico and In Vitro Study. Nanomaterials (Basel). 2018 Oct 19; 8(10). PMID: 30347680; PMCID: PMC6215209.
    Citations: 2     
  10. Kalhotra P, Chittepu VCSR, Osorio-Revilla G, Gallardo-Velázquez T. Structure?Activity Relationship and Molecular Docking of Natural Product Library Reveal Chrysin as a Novel Dipeptidyl Peptidase-4 (DPP-4) Inhibitor: An Integrated In Silico and In Vitro Study. Molecules. 2018 06 06; 23(6). PMID: 29882783.
    Citations: 16     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.