Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Richard Joseph Grand, M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R13HL088725 (GRAND, RICHARD J) Apr 20, 2007 - Mar 31, 2008
    NIH
    4th International Congress on Shwachman-Diamond Syndrome
    Role: Principal Investigator
  2. P30DK046200 (PERISSI, VALENTINA) Sep 30, 1992 - May 31, 2022
    NIH
    Boston Nutrition Obesity Research Center
    Role: Co-Principal Investigator
  3. U09RG011661 (GOLDSMITH, LOWELL ALAN) Jul 1, 1985 - Jun 30, 1992
    NIH
    GENERAL MEDICINE A STUDY SECTION
    Role: Co-Principal Investigator
  4. M01RR002172 (MANDELL, JAMES WILLIAM) Jan 1, 1983 - Mar 31, 2009
    NIH
    General Clinical Research Center
    Role: Co-Principal Investigator
  5. T32DK007471 (GRAND, RICHARD J) Jan 1, 1983 - Nov 30, 2004
    NIH
    PEDIATRIC GASTROENTEROLOGY RESEARCH TRAINING GRANT
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lusman SS, Borowitz D, Marshall BC, Narkewicz MR, Gonska T, Grand RJ, Simon RH, Mascarenhas MR, Schwarzenberg SJ, Freedman SD. DIGEST: Developing innovative gastroenterology specialty training. J Cyst Fibros. 2021 07; 20(4):586-590. PMID: 32736950; PMCID: PMC7387932.
    Citations:    Fields:    Translation:Humans
  2. Palmer NP, Silvester JA, Lee JJ, Beam AL, Fried I, Valtchinov VI, Rahimov F, Kong SW, Ghodoussipour S, Hood HC, Bousvaros A, Grand RJ, Kunkel LM, Kohane IS. Concordance between gene expression in peripheral whole blood and colonic tissue in children with inflammatory bowel disease. PLoS One. 2019; 14(10):e0222952. PMID: 31618209; PMCID: PMC6795427.
    Citations: 9     Fields:    Translation:Humans
  3. Leseva MN, Grand RJ, Klett H, Boerries M, Busch H, Binder AM, Michels KB. Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals. Sci Rep. 2018 04 04; 8(1):5649. PMID: 29618745.
    Citations: 9     Fields:    Translation:HumansCells
  4. Lifschitz CH, Vanderhoof J, Winter H, Guandalini S, Klish W, Grand R, Walker A, Perman J. Chapter 4. The Relationship Between the European and North American Societies for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2018 04; 66 Suppl 1:S44-S53. PMID: 29596164.
    Citations:    Fields:    Translation:Humans
  5. Nobile S, Grand RJ, Pappa HM. Risk factors for low bone mineral density in pediatric inflammatory bowel disease: the positive role of physical activity. Eur J Gastroenterol Hepatol. 2018 Apr; 30(4):471-476. PMID: 29438136.
    Citations: 7     Fields:    Translation:Humans
  6. Lusman SS, Grand R. Approach to chronic abdominal pain in Cystic Fibrosis. J Cyst Fibros. 2017 Nov; 16 Suppl 2:S24-S31. PMID: 28986021.
    Citations: 4     Fields:    Translation:Humans
  7. Grover AS, Kadiyala V, Banks PA, Grand RJ, Conwell DL, Lightdale JR. The Utility of the Systemic Inflammatory Respsonse Syndrome Score on Admission in Children With Acute Pancreatitis. Pancreas. 2017 01; 46(1):106-109. PMID: 27841791.
    Citations: 4     Fields:    Translation:Humans
  8. Ong MS, Grand RJ, Mandl KD. Trends in Pharmacologic Interventions for Preventing Recurrence of Crohn's Disease After Ileocolonic Surgery. Inflamm Bowel Dis. 2016 10; 22(10):2432-41. PMID: 27631599.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  9. Leung DH, Grand RJ. 50 Years Ago in TheJournal ofPediatrics: Macroscopic Cysts of the Pancreas in a Case of Cystic Fibrosis. J Pediatr. 2016 09; 176:133. PMID: 27568251.
    Citations:    Fields:    Translation:Humans
  10. Baffour-Awuah NY, Fleet S, Montgomery RK, Baker SS, Butler JL, Campbell C, Tischfield S, Mitchell PD, Allende-Richter S, Moon JE, Fishman L, Bousvaros A, Fox V, Kuokkanen M, Grand RJ, Hirschhorn JN. Functional significance of single nucleotide polymorphisms in the lactase gene in diverse US patients and evidence for a novel lactase persistence allele at -13909 in those of European ancestry. J Pediatr Gastroenterol Nutr. 2015 Feb; 60(2):182-91. PMID: 25625576; PMCID: PMC4308731.
    Citations: 7     Fields:    Translation:Humans
  11. Lee JJ, Mitchell PD, Hood HC, Grand RJ, Cohen LE. Potential role of IGF-1 z score to predict permanent linear growth impairment in children with IBD. J Pediatr Gastroenterol Nutr. 2014 Apr; 58(4):472-6. PMID: 24663033.
    Citations: 1     Fields:    Translation:Humans
  12. Sedgwick GG, Townsend K, Martin A, Shimwell NJ, Grand RJ, Stewart GS, Nilsson J, Turnell AS. Transcriptional intermediary factor 1? binds to the anaphase-promoting complex/cyclosome and promotes mitosis. Oncogene. 2013 Sep 26; 32(39):4622-33. PMID: 23160376; PMCID: PMC3882591.
    Citations: 11     Fields:    Translation:HumansCells
  13. Mrakotsky C, Forbes PW, Bernstein JH, Grand RJ, Bousvaros A, Szigethy E, Waber DP. Acute cognitive and behavioral effects of systemic corticosteroids in children treated for inflammatory bowel disease. J Int Neuropsychol Soc. 2013 Jan; 19(1):96-109. PMID: 23157730.
    Citations: 16     Fields:    Translation:Humans
  14. Pappa HM, Langereis EJ, Grand RJ, Gordon CM. Prevalence and risk factors for hypovitaminosis D in young patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2011 Oct; 53(4):361-4. PMID: 21613964.
    Citations: 20     Fields:    Translation:Humans
  15. Pappa HM, Saslowsky TM, Filip-Dhima R, DiFabio D, Hassani Lahsinoui H, Akkad A, Grand RJ, Gordon CM. Efficacy and harms of nasal calcitonin in improving bone density in young patients with inflammatory bowel disease: a randomized, placebo-controlled, double-blind trial. Am J Gastroenterol. 2011 Aug; 106(8):1527-43. PMID: 21519359.
    Citations: 6     Fields:    Translation:Humans
  16. Burpee T, Mitchell P, Fishman D, Islam S, Nemeth E, Westerman M, Wessling-Resnick M, Grand RJ. Intestinal ferroportin expression in pediatric Crohn's disease. Inflamm Bowel Dis. 2011 Feb; 17(2):524-31. PMID: 20564534.
    Citations: 2     Fields:    Translation:Humans
  17. Baffour-Awuah NY, Delemarre E, Fujiwara Y, Heijmans J, Boerwinkel D, Algra S, Fialkovich JJ, Islam S, Bosse T, Grand RJ, Krasinski SD, Montgomery RK. Characterization of expression in mice of a transgene containing 3.3 kb of the human lactase-phlorizin hydrolase (LPH) 5' flanking sequence. Dig Dis Sci. 2011 Jan; 56(1):59-69. PMID: 21086165; PMCID: PMC3408868.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  18. Lee JJ, Escher JC, Shuman MJ, Forbes PW, Delemarre LC, Harr BW, Kruijer M, Moret M, Allende-Richter S, Grand RJ. Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z-score. Inflamm Bowel Dis. 2010 Oct; 16(10):1669-77. PMID: 20127995.
    Citations: 22     Fields:    Translation:Humans
  19. Lee JJ, Essers JB, Kugathasan S, Escher JC, Lettre G, Butler JL, Stephens MC, Ramoni MF, Grand RJ, Hirschhorn J. Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. Ann Hum Genet. 2010 Nov; 74(6):489-97. PMID: 20846217; PMCID: PMC2955808.
    Citations: 10     Fields:    Translation:Humans
  20. Islam S, Loizides AM, Fialkovich JJ, Grand RJ, Montgomery RK. Developmental expression of Eph and ephrin family genes in mammalian small intestine. Dig Dis Sci. 2010 Sep; 55(9):2478-88. PMID: 20112066; PMCID: PMC3947671.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  21. Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D, Silber G, Wrobel I, Quiros A, Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmuda MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwillam R, Tremelling M, Delukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ, Heyman MB, Ferry GD, Kirschner B, Lee J, Essers J, Grand R, Stephens M, Levine A, Piccoli D, Van Limbergen J, Cucchiara S, Monos DS, Guthery SL, Denson L, Wilson DC, Grant SF, Daly M, Silverberg MS, Satsangi J, Hakonarson H. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. 2009 Dec; 41(12):1335-40. PMID: 19915574; PMCID: PMC3267927.
    Citations: 221     Fields:    Translation:Humans
  22. Essers JB, Lee JJ, Kugathasan S, Stevens CR, Grand RJ, Daly MJ. Established genetic risk factors do not distinguish early and later onset Crohn's disease. Inflamm Bowel Dis. 2009 Oct; 15(10):1508-14. PMID: 19322901.
    Citations: 19     Fields:    Translation:HumansCells
  23. Lu Y, Jacobson DL, Ashworth LA, Grand RJ, Meyer AL, McNeal MM, Gregas MC, Burchett SK, Bousvaros A. Immune response to influenza vaccine in children with inflammatory bowel disease. Am J Gastroenterol. 2009 Feb; 104(2):444-53. PMID: 19174786.
    Citations: 51     Fields:    Translation:HumansCellsCTClinical Trials
  24. Szigethy E, Craig AE, Iobst EA, Grand RJ, Keljo D, DeMaso D, Noll R. Profile of depression in adolescents with inflammatory bowel disease: implications for treatment. Inflamm Bowel Dis. 2009 Jan; 15(1):69-74. PMID: 18831071; PMCID: PMC2638168.
    Citations: 15     Fields:    Translation:Humans
  25. Shimwell NJ, Martin A, Bruton RK, Blackford AN, Sedgwick GG, Gallimore PH, Turnell AS, Grand RJ. Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway. Oncogene. 2009 Feb 05; 28(5):686-97. PMID: 19029952.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  26. Kappelman MD, Grand RJ. Does inflammatory bowel disease develop in infants? Inflamm Bowel Dis. 2008 Oct; 14 Suppl 2:S6-8. PMID: 18816729; PMCID: PMC3805279.
    Citations: 3     Fields:    Translation:Humans
  27. Peterson N, Guthery S, Denson L, Lee J, Saeed S, Prahalad S, Biank V, Ehlert R, Tomer G, Grand R, Rudolph C, Kugathasan S. Genetic variants in the autophagy pathway contribute to paediatric Crohn's disease. Gut. 2008 Sep; 57(9):1336-7; author reply 1337. PMID: 18719149.
    Citations: 10     Fields:    Translation:Humans
  28. Beuling E, Bosse T, aan de Kerk DJ, Piaseckyj CM, Fujiwara Y, Katz SG, Orkin SH, Grand RJ, Krasinski SD. GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Dev Biol. 2008 Oct 01; 322(1):179-89. PMID: 18692040.
    Citations: 25     Fields:    Translation:AnimalsCells
  29. Pappa HM, Bern E, Kamin D, Grand RJ. Vitamin D status in gastrointestinal and liver disease. Curr Opin Gastroenterol. 2008 Mar; 24(2):176-83. PMID: 18301268.
    Citations: 19     Fields:    Translation:Humans
  30. Grand RJ, Montgomery RK. Lactose malabsorption. Curr Treat Options Gastroenterol. 2008 Feb; 11(1):19-25. PMID: 21063860.
    Citations: 2     
  31. Montgomery RK, Krasinski SD, Hirschhorn JN, Grand RJ. Lactose and lactase--who is lactose intolerant and why? J Pediatr Gastroenterol Nutr. 2007 Dec; 45 Suppl 2:S131-7. PMID: 18185074.
    Citations: 11     Fields:    Translation:Humans
  32. Kappelman MD, Rifas-Shiman SL, Kleinman K, Ollendorf D, Bousvaros A, Grand RJ, Finkelstein JA. The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States. Clin Gastroenterol Hepatol. 2007 Dec; 5(12):1424-9. PMID: 17904915.
    Citations: 333     Fields:    Translation:Humans
  33. Kappelman MD, Bousvaros A, Hyams J, Markowitz J, Pfefferkorn M, Kugathasan S, Rosh J, Otley A, Mack D, Griffiths A, Evans J, Grand R, Langton C, Kleinman K, Finkelstein JA. Intercenter variation in initial management of children with Crohn's disease. Inflamm Bowel Dis. 2007 Jul; 13(7):890-5. PMID: 17286275.
    Citations: 28     Fields:    Translation:Humans
  34. Bruton RK, Rasti M, Mapp KL, Young N, Carter RZ, Abramowicz IA, Sedgwick GG, Onion DF, Shuen M, Mymryk JS, Turnell AS, Grand RJ. C-terminal-binding protein interacting protein binds directly to adenovirus early region 1A through its N-terminal region and conserved region 3. Oncogene. 2007 Nov 22; 26(53):7467-79. PMID: 17546052.
    Citations: 4     Fields:    Translation:HumansCells
  35. Richard Grand, MD, Christopher Duggan, MD, PhD, and Catherine Gordon, MD. Lactose Intolerance in Children. Pediatric Views. 2007; 3.
  36. Bosse T, Fialkovich JJ, Piaseckyj CM, Beuling E, Broekman H, Grand RJ, Montgomery RK, Krasinski SD. Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development. Am J Physiol Gastrointest Liver Physiol. 2007 May; 292(5):G1302-14. PMID: 17272516.
    Citations: 20     Fields:    Translation:Animals
  37. Pappa HM, Grand RJ, Gordon CM. Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease. Inflamm Bowel Dis. 2006 Dec; 12(12):1162-74. PMID: 17119391.
    Citations: 53     Fields:    Translation:Humans
  38. Semrin G, Fishman DS, Bousvaros A, Zholudev A, Saunders AC, Correia CE, Nemeth E, Grand RJ, Weinstein DA. Impaired intestinal iron absorption in Crohn's disease correlates with disease activity and markers of inflammation. Inflamm Bowel Dis. 2006 Dec; 12(12):1101-6. PMID: 17119383; PMCID: PMC2788427.
    Citations: 57     Fields:    Translation:Humans
  39. Pappa HM, Gordon CM, Saslowsky TM, Zholudev A, Horr B, Shih MC, Grand RJ. Vitamin D status in children and young adults with inflammatory bowel disease. Pediatrics. 2006 Nov; 118(5):1950-61. PMID: 17079566; PMCID: PMC3205440.
    Citations: 79     Fields:    Translation:Humans
  40. Saeed SA, Integlia MJ, Pleskow RG, Calenda KA, Rohrer RJ, Dayal Y, Grand RJ. Tacrolimus-associated eosinophilic gastroenterocolitis in pediatric liver transplant recipients: role of potential food allergies in pathogenesis. Pediatr Transplant. 2006 Sep; 10(6):730-5. PMID: 16911498.
    Citations: 21     Fields:    Translation:Humans
  41. Bosse T, van Wering HM, Gielen M, Dowling LN, Fialkovich JJ, Piaseckyj CM, Gonzalez FJ, Akiyama TE, Montgomery RK, Grand RJ, Krasinski SD. Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G1016-24. PMID: 16223943.
    Citations: 10     Fields:    Translation:AnimalsCells
  42. Islam S, Montgomery RK, Fialkovich JJ, Grand RJ. Developmental and regional expression and localization of mRNAs encoding proteins involved in RNA translocation. J Histochem Cytochem. 2005 Dec; 53(12):1501-9. PMID: 16009965; PMCID: PMC3957543.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  43. Hait E, Hait L, Bousvaros A, Grand R. Pediatric inflammatory bowel disease: what children can teach adults. Inflamm Bowel Dis. 2005 Jun; 11(6):519-27. PMID: 15905698.
    Citations: 12     Fields:    Translation:Humans
  44. Calenda KA, Schornagel IL, Sadeghi-Nejad A, Grand RJ. Effect of recombinant growth hormone treatment on children with Crohn's disease and short stature: a pilot study. Inflamm Bowel Dis. 2005 May; 11(5):435-41. PMID: 15867582.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  45. Grand RJ. Inverting the therapeutic triangle. J Pediatr Gastroenterol Nutr. 2005 Apr; 40 Suppl 1:S50-2. PMID: 15805856.
    Citations:    Fields:    Translation:Humans
  46. Fiocchi C, Cucchiara S, Czinn SJ, Grand RJ, Levine AD, Seidman EG. Introduction: First International Symposium on: pediatric inflammatory bowel disease: September 16-18, 2003; Irvington, Virginia, U.S.A. J Pediatr Gastroenterol Nutr. 2005 Apr; 40 Suppl 1:S1. PMID: 15805828.
    Citations:    Fields:    Translation:Humans
  47. Griffiths AM, Otley AR, Hyams J, Quiros AR, Grand RJ, Bousvaros A, Feagan BG, Ferry GR. A review of activity indices and end points for clinical trials in children with Crohn's disease. Inflamm Bowel Dis. 2005 Feb; 11(2):185-96. PMID: 15677913.
    Citations: 15     Fields:    Translation:Humans
  48. Verhave M, Krasinski SD, Christian SI, Van Schaik S, Van Den Brink GR, Doting EM, Maas SM, Wolthers KC, Grand RJ, Montgomery RK. Regulatory regions in the rat lactase-phlorizin hydrolase gene that control cell-specific expression. J Pediatr Gastroenterol Nutr. 2004 Sep; 39(3):275-85. PMID: 15319629.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  49. Pappa HM, Semrin G, Walker TR, Grand RJ. Pediatric inflammatory bowel disease. Curr Opin Gastroenterol. 2004 Jul; 20(4):333-40. PMID: 15703661.
    Citations: 3     Fields: