Harvard Catalyst Profiles

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Rene Maehr, B.S.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI132963 (BREHM, MICHAEL ALLEN) May 1, 2017 - Apr 30, 2022
    NIH/NIAID
    Novel humanized mouse model developed from cord blood CD34 positive HSC and autologous iPS cell derived thymus
    Role: Co-Principal Investigator
  2. DP3DK111898 (MEISSNER, ALEXANDER) Sep 30, 2016 - Jun 30, 2021
    NIH/NIDDK
    Deciphering the molecular basis of T1D in human cells using functional genomics
    Role: Co-Principal Investigator
  3. R56AI114525 (MAEHR, RENE) Aug 1, 2015 - Jul 31, 2016
    NIH/NIAID
    Using pluripotent stem cells to study gene dosage-dependent immunodeficiency
    Role: Principal Investigator
  4. R21AI119885 (MAEHR, RENE) Apr 15, 2015 - Mar 31, 2017
    NIH/NIAID
    Functionally dissecting the transcriptional regulatory network of the innate immune response using CRISPR-effectors
    Role: Principal Investigator
  5. U01DK104218 (GREINER, DALE LESLIE) Sep 25, 2014 - May 31, 2023
    NIH/NIDDK
    Humanized Mouse Avatars for T1D
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Han L, Choudhury S, Mich-Basso JD, Ammanamanchi N, Ganapathy B, Suresh S, Khaladkar M, Singh J, Maehr R, Zuppo DA, Kim J, Eberwine JH, Wyman SK, Wu YL, Kühn B. Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration. Dev Cell. 2020 Apr 06; 53(1):42-59.e11. PMID: 32109383.
    Citations:    
  2. Fischer DS, Fiedler AK, Kernfeld EM, Genga RMJ, Bastidas-Ponce A, Bakhti M, Lickert H, Hasenauer J, Maehr R, Theis FJ. Inferring population dynamics from single-cell RNA-sequencing time series data. Nat Biotechnol. 2019 04; 37(4):461-468. PMID: 30936567.
    Citations:    
  3. Chen YJ, Finkbeiner SR, Weinblatt D, Emmett MJ, Tameire F, Yousefi M, Yang C, Maehr R, Zhou Q, Shemer R, Dor Y, Li C, Spence JR, Stanger BZ. De novo formation of insulin-producing "neo-ß cell islets" from intestinal crypts. Cell Rep. 2014 Mar 27; 6(6):1046-1058. PMID: 24613355.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  4. Sherwood RI, Maehr R, Mazzoni EO, Melton DA. Wnt signaling specifies and patterns intestinal endoderm. Mech Dev. 2011 Sep-Dec; 128(7-10):387-400. PMID: 21854845.
    Citations: 39     Fields:    Translation:AnimalsCells
  5. Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME. The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell. 2010 Mar 05; 140(5):704-16. PMID: 20211139.
    Citations: 200     Fields:    Translation:HumansAnimalsCells
  6. Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 2010 Feb 01; 24(3):312-26. PMID: 20123909.
    Citations: 96     Fields:    Translation:AnimalsCells
  7. Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA. Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15768-73. PMID: 19720998.
    Citations: 191     Fields:    Translation:HumansCells
  8. Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 2009 Apr 03; 4(4):348-58. PMID: 19341624.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  9. Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr; 5(4):258-65. PMID: 19287398.
    Citations: 155     Fields:    Translation:HumansAnimalsCells
  10. Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol. 2008 Nov; 26(11):1269-75. PMID: 18849973.
    Citations: 452     Fields:    Translation:HumansAnimalsCells
  11. Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Ploegh HL, Plough HL, Barrett TA, Weissleder R, Khazaie K. Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One. 2008 Aug 13; 3(8):e2916. PMID: 18698347.
    Citations: 44     Fields:    Translation:AnimalsCells
  12. Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol. 2008 Jul; 26(7):795-7. PMID: 18568017.
    Citations: 528     Fields:    Translation:AnimalsCells
  13. Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ. SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature. 2008 Mar 20; 452(7185):370-4. PMID: 18354483.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  14. Ryu KY, Maehr R, Gilchrist CA, Long MA, Bouley DM, Mueller B, Ploegh HL, Kopito RR. The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J. 2007 Jun 06; 26(11):2693-706. PMID: 17491588.
    Citations: 51     Fields:    Translation:AnimalsCells
  15. Kumazaki K, Tirosh B, Maehr R, Boes M, Honjo T, Ploegh HL. AID-/-mus-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells. J Immunol. 2007 Feb 15; 178(4):2192-203. PMID: 17277124.
    Citations: 16     Fields:    Translation:AnimalsCells
  16. Hang HC, Loureiro J, Spooner E, van der Velden AW, Kim YM, Pollington AM, Maehr R, Starnbach MN, Ploegh HL. Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells. ACS Chem Biol. 2006 Dec 20; 1(11):713-23. PMID: 17184136.
    Citations: 20     Fields:    Translation:AnimalsCells
  17. Koch KS, Son KH, Maehr R, Pellicciotta I, Ploegh HL, Zanetti M, Sell S, Leffert HL. Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines. Immunology. 2006 Sep; 119(1):98-115. PMID: 16836618.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  18. Maehr R, Mintern JD, Herman AE, Lennon-Duménil AM, Mathis D, Benoist C, Ploegh HL. Cathepsin L is essential for onset of autoimmune diabetes in NOD mice. J Clin Invest. 2005 Oct; 115(10):2934-43. PMID: 16184198.
    Citations: 29     Fields:    Translation:AnimalsCells
  19. Maehr R, Hang HC, Mintern JD, Kim YM, Cuvillier A, Nishimura M, Yamada K, Shirahama-Noda K, Hara-Nishimura I, Ploegh HL. Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. J Immunol. 2005 Jun 01; 174(11):7066-74. PMID: 15905550.
    Citations: 32     Fields:    Translation:AnimalsCells
  20. Maehr R, Kraus M, Ploegh HL. Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment. Eur J Immunol. 2004 Aug; 34(8):2230-6. PMID: 15259020.
    Citations: 7     Fields:    Translation:AnimalsCells
  21. van Swieten PF, Maehr R, van den Nieuwendijk AM, Kessler BM, Reich M, Wong CS, Kalbacher H, Leeuwenburgh MA, Driessen C, van der Marel GA, Ploegh HL, Overkleeft HS. Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. Bioorg Med Chem Lett. 2004 Jun 21; 14(12):3131-4. PMID: 15149659.
    Citations: 3     Fields:    
  22. Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H, Ploegh HL, Coyle AJ, Rajewsky K. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4566-71. PMID: 15070758.
    Citations: 99     Fields:    Translation:AnimalsCells
  23. Kocks C, Maehr R, Overkleeft HS, Wang EW, Iyer LK, Lennon-Dumenil AM, Ploegh HL, Kessler BM. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Mol Cell Proteomics. 2003 Nov; 2(11):1188-97. PMID: 13130081.
    Citations: 11     Fields:    Translation:AnimalsCells
  24. Fiebiger E, Maehr R, Villadangos J, Weber E, Erickson A, Bikoff E, Ploegh HL, Lennon-Duménil AM. Invariant chain controls the activity of extracellular cathepsin L. J Exp Med. 2002 Nov 04; 196(9):1263-9. PMID: 12417635.
    Citations: 18     Fields:    Translation:AnimalsCells
  25. Vugmeyster Y, Borodovsky A, Maurice MM, Maehr R, Furman MH, Ploegh HL. The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP). Mol Immunol. 2002 Nov; 39(7-8):431-41. PMID: 12413694.
    Citations: 6     Fields:    Translation:AnimalsCells
  26. Lennon-Duménil AM, Bakker AH, Maehr R, Fiebiger E, Overkleeft HS, Rosemblatt M, Ploegh HL, Lagaudrière-Gesbert C. Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. J Exp Med. 2002 Aug 19; 196(4):529-40. PMID: 12186844.
    Citations: 59     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.