Harvard Catalyst Profiles

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Robert Pleasants Sparks, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Patel RS, Lui A, Hudson C, Moss L, Sparks RP, Hill SE, Shi Y, Cai J, Blair LJ, Bickford PC, Patel NA. Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model. Sci Rep. 2023 01 06; 13(1):317. PMID: 36609440; PMCID: PMC9822944.
    Citations:    Fields:    Translation:AnimalsCells
  2. Sparks RP, Arango AS, Starr ML, Aboff ZL, Hurst LR, Rivera-Kohr DA, Zhang C, Harnden KA, Jenkins JL, Guida WC, Tajkhorshid E, Fratti RA. Correction: A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion. J Biol Chem. 2022 Nov; 298(11):102576. PMID: 36257250; PMCID: PMC9579040.
    Citations:    Fields:    
  3. Patel A, Dobbins T, Kong X, Patel R, Carter G, Harding L, Sparks RP, Patel NA, Cooper DR. Induction of beige-like adipocyte markers and functions in 3T3-L1 cells by Clk1 and PKCßII inhibitory molecules. J Cell Mol Med. 2022 08; 26(15):4183-4194. PMID: 35801494; PMCID: PMC9344812.
    Citations:    Fields:    
  4. Li W, Chen JY, Sun C, Sparks RP, Pantano L, Rahman RU, Moran SP, Pondick JV, Kirchner R, Wrobel D, Bieler M, Sauer A, Ho Sui SJ, Doerner JF, Rippmann JF, Mullen AC. Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. Elife. 2022 05 26; 11. PMID: 35617485; PMCID: PMC9135407.
    Citations:    Fields:    Translation:HumansCells
  5. Sparks RP, Lawless W, Arango AS, Tajkhorshid E, Fratti RA. Use of Microscale Thermophoresis to Measure Protein-Lipid Interactions. J Vis Exp. 2022 02 10; (180). PMID: 35225279.
    Citations:    Fields:    Translation:Cells
  6. Sparks RP, Arango AS, Jenkins JL, Guida WC, Tajkhorshid E, Sparks CE, Sparks JD, Fratti RA. An Allosteric Binding Site on Sortilin Regulates the Trafficking of VLDL, PCSK9, and LDLR in Hepatocytes. Biochemistry. 2020 11 17; 59(45):4321-4335. PMID: 33153264.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Sparks RP, Arango AS, Starr ML, Aboff ZL, Hurst LR, Rivera-Kohr DA, Zhang C, Harnden KA, Jenkins JL, Guida WC, Tajkhorshid E, Fratti RA. A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion. J Biol Chem. 2019 11 15; 294(46):17168-17185. PMID: 31515268; PMCID: PMC6873166.
    Citations: 2     Fields:    Translation:AnimalsCells
  8. Starr ML, Sparks RP, Arango AS, Hurst LR, Zhao Z, Lihan M, Jenkins JL, Tajkhorshid E, Fratti RA. Phosphatidic acid induces conformational changes in Sec18 protomers that prevent SNARE priming. J Biol Chem. 2019 03 01; 294(9):3100-3116. PMID: 30617180.
    Citations: 9     Fields:    Translation:AnimalsCells
  9. Sparks RP, Jenkins JL, Fratti R. Use of Surface Plasmon Resonance (SPR) to Determine Binding Affinities and Kinetic Parameters Between Components Important in Fusion Machinery. Methods Mol Biol. 2019; 1860:199-210. PMID: 30317506.
    Citations: 6     Fields:    Translation:Cells
  10. Sparks RP, Fratti R. Use of Microscale Thermophoresis (MST) to Measure Binding Affinities of Components of the Fusion Machinery. Methods Mol Biol. 2019; 1860:191-198. PMID: 30317505.
    Citations: 7     Fields:    Translation:Cells
  11. Sparks RP, Jenkins JL, Miner GE, Wang Y, Guida WC, Sparks CE, Fratti RA, Sparks JD. Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding. Biochem Biophys Res Commun. 2016 Oct 21; 479(3):551-556. PMID: 27666481; PMCID: PMC5056161.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  12. Sparks RP, Guida WC, Sowden MP, Jenkins JL, Starr ML, Fratti RA, Sparks CE, Sparks JD. Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells. Biochem Biophys Res Commun. 2016 09 16; 478(2):546-52. PMID: 27495870; PMCID: PMC5002383.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  13. Miner GE, Starr ML, Hurst LR, Sparks RP, Padolina M, Fratti RA. The Central Polybasic Region of the Soluble SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Vam7 Affects Binding to Phosphatidylinositol 3-Phosphate by the PX (Phox Homology) Domain. J Biol Chem. 2016 08 19; 291(34):17651-63. PMID: 27365394.
    Citations: 12     Fields:    Translation:AnimalsCells
  14. Sparks CE, Sparks RP, Sparks JD. The enigmatic role of sortilin in lipoprotein metabolism. Curr Opin Lipidol. 2015 Dec; 26(6):598-600. PMID: 26780014; PMCID: PMC4725061.
    Citations: 7     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.