Harvard Catalyst Profiles

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Cenk Ayata, M.D.

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Other Positions
Title
Institution
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01NS115401 (SAKADZIC, SAVA) May 1, 2020 - Apr 30, 2025
    NIH
    Investigating the microvascular mechanisms of O2 supply-demand mismatch in small vessel disease using novel high-resolution optical imaging
    Role: Co-Principal Investigator
  2. U01NS113443 (AYATA, CENK) Sep 15, 2019 - Jul 31, 2022
    NIH
    Multicenter preclinical trial of rho-kinase inhibitor fasudil in acute focal cerebral ischemia and reperfusion
    Role: Principal Investigator
  3. R01NS102969 (AYATA, CENK) Jul 15, 2017 - Apr 30, 2022
    NIH
    Non-invasive vagus nerve stimulation targeting cortical spreading depression in migrane prophylaxis
    Role: Principal Investigator
  4. R01NS061505 (AYATA, CENK) Jan 15, 2008 - Dec 31, 2013
    NIH
    Neural & Vascular Dysfunction As Mechanisms of Injury in Genetic Migraine Models
    Role: Principal Investigator
  5. P01NS055104 (LO, ENG H.) Jul 1, 2007 - Apr 30, 2020
    NIH
    Remodeling and recovery in the neurovascular unit
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shin P, Pian Q, Ishikawa H, Hamanaka G, Mandeville ET, Shuzhen G, Buyin F, Alfadhel M, Allu SR, Sencan-Egilmez I, Li B, Ran C, Vinogradov SA, Ayata C, Lo EH, Arai K, Devor A, Sakadžic S. Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation. bioRxiv. 2023 Feb 13. PMID: 36824939; PMCID: PMC9949059.
    Citations:    
  2. Morais A, Locascio JJ, Sansing LH, Lamb J, Nagarkatti K, Imai T, van Leyen K, Aronowski J, Koenig JI, Bosetti F, Lyden P, Ayata C. Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial. Stroke. 2023 Feb; 54(2):620-631. PMID: 36601951; PMCID: PMC9870939.
    Citations:    Fields:    Translation:Animals
  3. Sacco S, Harriott AM, Ayata C, Ornello R, Bagur R, Jimenez-Ruiz A, Sposato LA. Microembolism and Other Links Between Migraine and Stroke: Clinical and Pathophysiologic Update. Neurology. 2022 Dec 15. PMID: 36522158.
    Citations:    Fields:    
  4. Aykan SA, Xie H, Zheng Y, Chung DY, Kura S, Han Lai J, Erdogan TD, Morais A, Tamim I, Yagmur D, Ishikawa H, Arai K, Abbas Yaseen M, Boas DA, Sakadzic S, Ayata C. Rho-Kinase Inhibition Improves the Outcome of Focal Subcortical White Matter Lesions. Stroke. 2022 07; 53(7):2369-2376. PMID: 35656825; PMCID: PMC9245195.
    Citations:    Fields:    Translation:HumansAnimals
  5. Oka F, Lee JH, Yuzawa I, Li M, von Bornstaedt D, Eikermann-Haerter K, Qin T, Chung DY, Sadeghian H, Seidel JL, Imai T, Vuralli D, Platt RM, Nelson MT, Joutel A, Sakadzic S, Ayata C. CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis. J Clin Invest. 2022 04 15; 132(8). PMID: 35202003; PMCID: PMC9012276.
    Citations:    Fields:    Translation:Animals
  6. Lai JH, Qin T, Sakadžic S, Ayata C, Chung DY. Correction to: Cortical Spreading Depolarizations in a Mouse Model of Subarachnoid Hemorrhage. Neurocrit Care. 2022 Apr; 36(2):689. PMID: 35041114.
    Citations:    Fields:    
  7. Lyden PD, Bosetti F, Diniz MA, Rogatko A, Koenig JI, Lamb J, Nagarkatti KA, Cabeen RP, Hess DC, Kamat PK, Khan MB, Wood K, Dhandapani K, Arbab AS, Leira EC, Chauhan AK, Dhanesha N, Patel RB, Kumskova M, Thedens D, Morais A, Imai T, Qin T, Ayata C, Boisserand LSB, Herman AL, Beatty HE, Velazquez SE, Diaz-Perez S, Sanganahalli BG, Mihailovic JM, Hyder F, Sansing LH, Koehler RC, Lannon S, Shi Y, Karuppagounder SS, Bibic A, Akhter K, Aronowski J, McCullough LD, Chauhan A, Goh A. The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results. Stroke. 2022 05; 53(5):1802-1812. PMID: 35354299; PMCID: PMC9038686.
    Citations:    Fields:    Translation:HumansAnimals
  8. Oka F, Sadeghian H, Yaseen MA, Fu B, Kura S, Qin T, Sakadžic S, Sugimoto K, Inoue T, Ishihara H, Nomura S, Suzuki M, Ayata C. Intracranial pressure spikes trigger spreading depolarizations. Brain. 2022 03 29; 145(1):194-207. PMID: 34245240; PMCID: PMC9126007.
    Citations: 1     Fields:    Translation:Humans
  9. Vuralli D, Arslan B, Topa E, de Morais AL, Gulbahar O, Ayata C, Bolay H. Migraine susceptibility is modulated by food triggers and analgesic overuse via sulfotransferase inhibition. J Headache Pain. 2022 Mar 14; 23(1):36. PMID: 35282834; PMCID: PMC8919627.
    Citations:    Fields:    Translation:HumansAnimals
  10. Andrew RD, Hartings JA, Ayata C, Brennan KC, Dawson-Scully KD, Farkas E, Herreras O, Kirov SA, Müller M, Ollen-Bittle N, Reiffurth C, Revah O, Robertson RM, Shuttleworth CW, Ullah G, Dreier JP. The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention. Neurocrit Care. 2022 06; 37(Suppl 1):83-101. PMID: 35257321; PMCID: PMC9259543.
    Citations: 2     Fields:    Translation:Humans
  11. Andrew RD, Farkas E, Hartings JA, Brennan KC, Herreras O, Müller M, Kirov SA, Ayata C, Ollen-Bittle N, Reiffurth C, Revah O, Robertson RM, Dawson-Scully KD, Ullah G, Dreier JP. Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization. Neurocrit Care. 2022 06; 37(Suppl 1):11-30. PMID: 35194729; PMCID: PMC9259542.
    Citations: 1     Fields:    Translation:Humans
  12. Liu TT, Morais A, Takizawa T, Mulder I, Simon BJ, Chen SP, Wang SJ, Ayata C, Yen JC. Efficacy profile of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model. J Headache Pain. 2022 Jan 21; 23(1):12. PMID: 35062860; PMCID: PMC8903561.
    Citations:    Fields:    Translation:Animals
  13. Ferrari MD, Goadsby PJ, Burstein R, Kurth T, Ayata C, Charles A, Ashina M, van den Maagdenberg AMJM, Dodick DW. Migraine. Nat Rev Dis Primers. 2022 01 13; 8(1):2. PMID: 35027572.
    Citations: 3     Fields:    Translation:Humans
  14. Lai JH, Qin T, Sakadžic S, Ayata C, Chung DY. Cortical Spreading Depolarizations in a Mouse Model of Subarachnoid Hemorrhage. Neurocrit Care. 2022 06; 37(Suppl 1):123-132. PMID: 34981426; PMCID: PMC9250554.
    Citations:    Fields:    Translation:Animals
  15. Aykan SA, Xie H, Lai JH, Zheng Y, Chung DY, Kura S, Anzabi M, Sugimoto K, McAllister LM, Yaseen MA, Boas DA, Whalen MJ, Sakadzic S, Ayata C. Focal Subcortical White Matter Lesions Disrupt Resting State Cortical Interhemispheric Functional Connectivity in Mice. Cereb Cortex. 2021 10 01; 31(11):4958-4969. PMID: 34037216; PMCID: PMC8491690.
    Citations: 1     Fields:    Translation:HumansAnimals
  16. Smith EE, Charidimou A, Ayata C, Werring DJ, Greenberg SM. Cerebral Amyloid Angiopathy-Related Transient Focal Neurologic Episodes. Neurology. 2021 08 03; 97(5):231-238. PMID: 34016709; PMCID: PMC8356377.
    Citations: 1     Fields:    Translation:Humans
  17. Tamim I, Chung DY, de Morais AL, Loonen ICM, Qin T, Misra A, Schlunk F, Endres M, Schiff SJ, Ayata C. Spreading depression as an innate antiseizure mechanism. Nat Commun. 2021 04 13; 12(1):2206. PMID: 33850125; PMCID: PMC8044138.
    Citations: 5     Fields:    Translation:Animals
  18. Anzabi M, Li B, Wang H, Kura S, Sakadžic S, Boas D, Østergaard L, Ayata C. Optical coherence tomography of arteriolar diameter and capillary perfusion during spreading depolarizations. J Cereb Blood Flow Metab. 2021 09; 41(9):2256-2263. PMID: 33593116; PMCID: PMC8393288.
    Citations:    Fields:    Translation:HumansAnimals
  19. Sugimoto K, Morais A, Sadeghian H, Qin T, Chung DY, Ashina M, Hougaard A, Ayata C. Intravascular Endothelin-1 does not trigger or increase susceptibility to Spreading Depolarizations. J Headache Pain. 2020 Oct 27; 21(1):127. PMID: 33109086.
    Citations:    Fields:    Translation:HumansAnimals
  20. Harriott AM, Chung DY, Uner A, Bozdayi RO, Morais A, Takizawa T, Qin T, Ayata C. Optogenetic Spreading Depression Elicits Trigeminal Pain and Anxiety Behavior. Ann Neurol. 2021 01; 89(1):99-110. PMID: 33016466.
    Citations: 10     Fields:    Translation:Animals
  21. Fischer P, Sugimoto K, Chung DY, Tamim I, Morais A, Takizawa T, Qin T, Gomez CA, Schlunk F, Endres M, Yaseen MA, Sakadzic S, Ayata C. Rapid hematoma growth triggers spreading depolarizations in experimental intracortical hemorrhage. J Cereb Blood Flow Metab. 2021 06; 41(6):1264-1276. PMID: 32936730; PMCID: PMC8142136.
    Citations: 2     Fields:    Translation:Animals
  22. Chung DY, Oka F, Jin G, Harriott A, Kura S, Aykan SA, Qin T, Edmiston WJ, Lee H, Yaseen MA, Sakadžic S, Boas DA, Whalen MJ, Ayata C. Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice. J Cereb Blood Flow Metab. 2021 05; 41(5):975-985. PMID: 32936728.
    Citations: 7     Fields:    Translation:Animals
  23. Yanagisawa T, Zhang H, Suzuki T, Kamio Y, Takizawa T, Morais A, Chung DY, Qin T, Murayama Y, Faber JE, Patel AB, Ayata C. Sex and Genetic Background Effects on the Outcome of Experimental Intracranial Aneurysms. Stroke. 2020 10; 51(10):3083-3094. PMID: 32912097.
    Citations: 4     Fields:    Translation:Animals
  24. Mulder IA, Li M, de Vries T, Qin T, Yanagisawa T, Sugimoto K, van den Bogaerdt A, Danser AHJ, Wermer MJH, van den Maagdenberg AMJM, MaassenVanDenBrink A, Ferrari MD, Ayata C. Anti-migraine Calcitonin Gene-Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice. Ann Neurol. 2020 10; 88(4):771-784. PMID: 32583883; PMCID: PMC7540520.
    Citations: 16     Fields:    Translation:HumansAnimals
  25. Sugimoto K, Chung DY, Böhm M, Fischer P, Takizawa T, Aykan SA, Qin T, Yanagisawa T, Harriott A, Oka F, Yaseen MA, Sakadžic S, Ayata C. Peri-Infarct Hot-Zones Have Higher Susceptibility to Optogenetic Functional Activation-Induced Spreading Depolarizations. Stroke. 2020 08; 51(8):2526-2535. PMID: 32640946.
    Citations: 4     Fields:    Translation:Animals
  26. Negro A, Seidel JL, Houben T, Yu ES, Rosen I, Arreguin AJ, Yalcin N, Shorser-Gentile L, Pearlman L, Sadhegian H, Vetrivelan R, Chamberlin NL, Ayata C, Martelletti P, Moskowitz MA, Eikermann-Haerter K. Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization. J Headache Pain. 2020 Jul 06; 21(1):86. PMID: 32631251.
    Citations: 5     Fields:    Translation:Animals
  27. Morais A, Liu TT, Qin T, Sadhegian H, Ay I, Yagmur D, Mendes da Silva R, Chung D, Simon B, Guedes R, Chen SP, Wang SJ, Yen JC, Ayata C. Vagus nerve stimulation inhibits cortical spreading depression exclusively through central mechanisms. Pain. 2020 07; 161(7):1661-1669. PMID: 32142015; PMCID: PMC7305968.
    Citations: 10     Fields:    Translation:Animals
  28. Takizawa T, Ayata C, Chen SP. Therapeutic implications of cortical spreading depression models in migraine. Prog Brain Res. 2020; 255:29-67. PMID: 33008510.
    Citations: 4     Fields:    Translation:HumansAnimals
  29. Wuggenig P, Kaya B, Melhem H, Ayata CK, Hruz P, Sayan AE, Tsumura H, Ito M, Roux J, Niess JH. Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice. Commun Biol. 2020 03 18; 3(1):130. PMID: 32188932.
    Citations: 8     Translation:HumansAnimalsCells
  30. Shuttleworth CW, Andrew RD, Akbari Y, Ayata C, Balu R, Brennan KC, Boutelle M, Carlson AP, Dreier JP, Fabricius M, Farkas E, Foreman B, Helbok R, Henninger N, Jewell SL, Jones SC, Kirov SA, Lindquist BE, Maciel CB, Okonkwo D, Reinhart KM, Robertson RM, Rosenthal ES, Watanabe T, Hartings JA. Which Spreading Depolarizations Are Deleterious To Brain Tissue? Neurocrit Care. 2020 02; 32(1):317-322. PMID: 31388871; PMCID: PMC7002178.
    Citations: 12     Fields:    Translation:HumansAnimals
  31. Helbok R, Hartings JA, Schiefecker A, Balança B, Jewel S, Foreman B, Ercole A, Balu R, Ayata C, Ngwenya L, Rosenthal E, Boutelle MG, Farkas E, Dreier JP, Fabricius M, Shuttleworth CW, Carlson A. What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient? Neurocrit Care. 2020 02; 32(1):306-310. PMID: 31338747; PMCID: PMC6980932.
    Citations: 8     Fields:    Translation:Humans
  32. Oka F, Chung DY, Suzuki M, Ayata C. Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental-Clinical Disconnect and the Unmet Need. Neurocrit Care. 2020 02; 32(1):238-251. PMID: 30671784; PMCID: PMC7387950.
    Citations: 11     Fields:    Translation:Animals
  33. Hougaard A, Younis S, Iljazi A, Sugimoto K, Ayata C, Ashina M. Intravenous Endothelin-1 Infusion Does Not Induce Aura or Headache in Migraine Patients With Aura. Headache. 2020 04; 60(4):724-734. PMID: 31994720.
    Citations: 5     Fields:    Translation:Humans
  34. Schulien I, Hockenjos B, van Marck V, Ayata CK, Follo M, Thimme R, Hasselblatt P. Extracellular ATP and Purinergic P2Y2 Receptor Signaling Promote Liver Tumorigenesis in Mice by Exacerbating DNA Damage. Cancer Res. 2020 02 15; 80(4):699-708. PMID: 31822494.
    Citations: 12     Fields:    Translation:AnimalsCells
  35. Chen X, Sobczak F, Chen Y, Jiang Y, Qian C, Lu Z, Ayata C, Logothetis NK, Yu X. Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus. Nat Commun. 2019 11 20; 10(1):5239. PMID: 31748553; PMCID: PMC6868210.
    Citations: 20     Fields:    Translation:AnimalsCells
  36. Harriott AM, Karakaya F, Ayata C. Headache after ischemic stroke: A systematic review and meta-analysis. Neurology. 2020 01 07; 94(1):e75-e86. PMID: 31694924.
    Citations: 8     Fields:    Translation:Humans
  37. Hougaard A, Younis S, Iljazi A, Haanes KA, Lindberg U, Vestergaard MB, Amin FM, Sugimoto K, Kruse LS, Ayata C, Ashina M. Cerebrovascular effects of endothelin-1 investigated using high-resolution magnetic resonance imaging in healthy volunteers. J Cereb Blood Flow Metab. 2020 08; 40(8):1685-1694. PMID: 31500524.
    Citations: 5     Fields:    Translation:Humans
  38. Shvedova M, Litvak MM, Roberts JD, Fukumura D, Suzuki T, Sencan I, Li G, Reventun P, Buys ES, Kim HH, Sakadžic S, Ayata C, Huang PL, Feil R, Atochin DN. cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice. J Cereb Blood Flow Metab. 2019 12; 39(12):2379-2391. PMID: 31423931.
    Citations: 2     Fields:    Translation:AnimalsCells
  39. Balkaya M, Seidel JL, Sadeghian H, Qin T, Chung DY, Eikermann-Haerter K, van den Maagdenberg AMJM, Ferrari MD, Ayata C. Relief Following Chronic Stress Augments Spreading Depolarization Susceptibility in Familial Hemiplegic Migraine Mice. Neuroscience. 2019 09 01; 415:1-9. PMID: 31299346.
    Citations: 2     Fields:    Translation:Animals
  40. Takizawa T, Qin T, Lopes de Morais A, Sugimoto K, Chung JY, Morsett L, Mulder I, Fischer P, Suzuki T, Anzabi M, Böhm M, Qu WS, Yanagisawa T, Hickman S, Khoury JE, Whalen MJ, Harriott AM, Chung DY, Ayata C. Non-invasively triggered spreading depolarizations induce a rapid pro-inflammatory response in cerebral cortex. J Cereb Blood Flow Metab. 2020 05; 40(5):1117-1131. PMID: 31242047.
    Citations: 20     Fields:    Translation:Animals
  41. Radulovic K, Ayata CK, Mak'Anyengo R, Lechner K, Wuggenig P, Kaya B, Hruz P, Gomez de Agüero M, Broz P, Weigmann B, Niess JH. NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death. J Immunol. 2019 07 15; 203(2):544-556. PMID: 31152078.
    Citations: 4     Fields:    Translation:AnimalsCells
  42. Regenhardt RW, Das AS, Ohtomo R, Lo EH, Ayata C, Gurol ME. Pathophysiology of Lacunar Stroke: History's Mysteries and Modern Interpretations. J Stroke Cerebrovasc Dis. 2019 Aug; 28(8):2079-2097. PMID: 31151839.
    Citations: 12     Fields:    Translation:HumansAnimals
  43. Xie H, Chung DY, Kura S, Sugimoto K, Aykan SA, Wu Y, Sakadžic S, Yaseen MA, Boas DA, Ayata C. Differential effects of anesthetics on resting state functional connectivity in the mouse. J Cereb Blood Flow Metab. 2020 04; 40(4):875-884. PMID: 31092086.
    Citations: 12     Fields:    Translation:Animals
  44. Böhm M, Chung DY, Gómez CA, Qin T, Takizawa T, Sadeghian H, Sugimoto K, Sakadžic S, Yaseen MA, Ayata C. Neurovascular coupling during optogenetic functional activation: Local and remote stimulus-response characteristics, and uncoupling by spreading depression. J Cereb Blood Flow Metab. 2020 04; 40(4):808-822. PMID: 31063009.
    Citations: 6     Fields:    Translation:Animals
  45. Schlunk F, Böhm M, Boulouis G, Qin T, Arbel M, Tamim I, Fischer P, Bacskai BJ, Frosch MP, Endres M, Greenberg SM, Ayata C. Secondary Bleeding During Acute Experimental Intracerebral Hemorrhage. Stroke. 2019 05; 50(5):1210-1215. PMID: 31009358; PMCID: PMC6478448.
    Citations: 4     Fields:    Translation:Animals
  46. Suzuki T, Takizawa T, Kamio Y, Qin T, Hashimoto T, Fujii Y, Murayama Y, Patel AB, Ayata C. Noninvasive Vagus Nerve Stimulation Prevents Ruptures and Improves Outcomes in a Model of Intracranial Aneurysm in Mice. Stroke. 2019 05; 50(5):1216-1223. PMID: 30943885; PMCID: PMC6476688.
    Citations: 5     Fields:    Translation:Animals
  47. Ashina M, Ayata C. Neurovascular origin of primary headaches. J Cereb Blood Flow Metab. 2019 04; 39(4):571-572. PMID: 30929598; PMCID: PMC6446421.
    Citations:    Fields:    Translation:Humans
  48. Chung DY, Sadeghian H, Qin T, Lule S, Lee H, Karakaya F, Goins S, Oka F, Yaseen MA, Houben T, Tolner EA, van den Maagdenberg AMJM, Whalen MJ, Sakadžic S, Ayata C. Determinants of Optogenetic Cortical Spreading Depolarizations. Cereb Cortex. 2019 03 01; 29(3):1150-1161. PMID: 29425263.
    Citations: 15     Fields:    Translation:AnimalsCells
  49. Vuralli D, Ayata C, Bolay H. Cognitive dysfunction and migraine. J Headache Pain. 2018 Nov 15; 19(1):109. PMID: 30442090; PMCID: PMC6755588.
    Citations: 34     Fields:    Translation:Humans
  50. Chung DY, Sugimoto K, Fischer P, Böhm M, Takizawa T, Sadeghian H, Morais A, Harriott A, Oka F, Qin T, Henninger N, Yaseen MA, Sakadžic S, Ayata C. Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice. J Neurosci Methods. 2018 11 01; 309:143-146. PMID: 30194041; PMCID: PMC6214472.
    Citations: 15     Fields:    Translation:Animals
  51. Sadeghian H, Lacoste B, Qin T, Toussay X, Rosa R, Oka F, Chung DY, Takizawa T, Gu C, Ayata C. Spreading depolarizations trigger caveolin-1-dependent endothelial transcytosis. Ann Neurol. 2018 09; 84(3):409-423. PMID: 30014540.
    Citations: 33     Fields:    Translation:AnimalsCells
  52. Bouley J, Chung DY, Ayata C, Brown RH, Henninger N. Cortical Spreading Depression Denotes Concussion Injury. J Neurotrauma. 2019 04 01; 36(7):1008-1017. PMID: 29999455; PMCID: PMC6444888.
    Citations: 14     Fields:    Translation:Animals
  53. Ayata C. Monitoring anoxic depolarization at the bedside: A step closer to the 24th century. J Cereb Blood Flow Metab. 2018 07; 38(7):1123-1124. PMID: 29961421; PMCID: PMC6434453.
    Citations: 3     Fields:    Translation:Humans
  54. Rosenthal ES, Biswal S, Zafar SF, O'Connor KL, Bechek S, Shenoy AV, Boyle EJ, Shafi MM, Gilmore EJ, Foreman BP, Gaspard N, Leslie-Mazwi TM, Rosand J, Hoch DB, Ayata C, Cash SS, Cole AJ, Patel AB, Westover MB. Continuous electroencephalography predicts delayed cerebral ischemia after subarachnoid hemorrhage: A prospective study of diagnostic accuracy. Ann Neurol. 2018 05; 83(5):958-969. PMID: 29659050; PMCID: PMC6021198.
    Citations: 23     Fields:    Translation:Humans
  55. Akhter M, Qin T, Fischer P, Sadeghian H, Kim HH, Whalen MJ, Goldstein JN, Ayata C. Rho-kinase inhibitors do not expand hematoma volume in acute experimental intracerebral hemorrhage. Ann Clin Transl Neurol. 2018 Jun; 5(6):769-776. PMID: 29928660.
    Citations: 4     Fields:    
  56. Lan J, Esposito E, Ayata C, Singhal AB, Lo EH, Ji X. Different Effects of Normobaric Oxygen in Normotensive Versus Hypertensive Rats After Focal Cerebral Ischemia. Stroke. 2018 06; 49(6):1534-1537. PMID: 29712880.
    Citations: 5     Fields:    Translation:Animals
  57. Xie H, Yu K, Zhou N, Shen X, Tian S, Zhang B, Wang Y, Wu J, Liu G, Jiang C, Hu R, Ayata C, Wu Y. Enriched Environment Elicits Proangiogenic Mechanisms After Focal Cerebral Ischemia. Transl Stroke Res. 2019 04; 10(2):150-159. PMID: 29700717.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  58. Yalcin N, Chen SP, Yu ES, Liu TT, Yen JC, Atalay YB, Qin T, Celik F, van den Maagdenberg AM, Moskowitz MA, Ayata C, Eikermann-Haerter K. Caffeine does not affect susceptibility to cortical spreading depolarization in mice. J Cereb Blood Flow Metab. 2019 04; 39(4):740-750. PMID: 29651899; PMCID: PMC6446422.
    Citations: 6     Fields:    Translation:Animals
  59. Bix GJ, Fraser JF, Mack WJ, Carmichael ST, Perez-Pinzon M, Offner H, Sansing L, Bosetti F, Ayata C, Pennypacker KR. Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical. Transl Stroke Res. 2018 06; 9(3):258-266. PMID: 29633156; PMCID: PMC5982459.
    Citations: 6     Fields:    Translation:HumansAnimals
  60. Iljazi A, Ayata C, Ashina M, Hougaard A. The Role of Endothelin in the Pathophysiology of Migraine-a Systematic Review. Curr Pain Headache Rep. 2018 Mar 19; 22(4):27. PMID: 29557064.
    Citations: 11     Fields:    Translation:HumansAnimals
  61. Waddington DEJ, Sarracanie M, Salameh N, Herisson F, Ayata C, Rosen MS. An Overhauser-enhanced-MRI platform for dynamic free radical imaging in vivo. NMR Biomed. 2018 05; 31(5):e3896. PMID: 29493032.
    Citations: 4     Fields:    Translation:Animals
  62. Kura S, Xie H, Fu B, Ayata C, Boas DA, Sakadžic S. Intrinsic optical signal imaging of the blood volume changes is sufficient for mapping the resting state functional connectivity in the rodent cortex. J Neural Eng. 2018 06; 15(3):035003. PMID: 29451130.
    Citations: 15     Fields:    Translation:Animals
  63. Liebeskind DS, Ayata C, Brown S, Raychev R, Scalzo F, Broderick JP, Tomsick TA, Cipolla MJ. Abstract 79: Chronic and Acute Hypertension in Ischemic Stroke Are Distinct Markers of Impaired Collateral Circulation. Stroke. 2018 Jan 22; 49(Suppl_1):A79. PMID: 30520353.
    Citations:    Fields:    
  64. Herisson F, Zhou I, Mawet J, Du E, Barfejani AH, Qin T, Cipolla MJ, Sun PZ, Rost NS, Ayata C. Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet. J Cereb Blood Flow Metab. 2019 07; 39(7):1232-1246. PMID: 29350576; PMCID: PMC6668522.
    Citations: 4     Fields:    Translation:HumansAnimals
  65. Chen SP, Ayata C. Novel Therapeutic Targets Against Spreading Depression. Headache. 2017 Oct; 57(9):1340-1358. PMID: 28842982.
    Citations: 7     Fields:    Translation:HumansAnimals
  66. Bosetti F, Koenig JI, Ayata C, Back SA, Becker K, Broderick JP, Carmichael ST, Cho S, Cipolla MJ, Corbett D, Corriveau RA, Cramer SC, Ferguson AR, Finklestein SP, Ford BD, Furie KL, Hemmen TM, Iadecola C, Jakeman LB, Janis S, Jauch EC, Johnston KC, Kochanek PM, Kohn H, Lo EH, Lyden PD, Mallard C, McCullough LD, McGavern LM, Meschia JF, Moy CS, Perez-Pinzon MA, Ramadan I, Savitz SI, Schwamm LH, Steinberg GK, Stenzel-Poore MP, Tymianski M, Warach S, Wechsler LR, Zhang JH, Koroshetz W. Translational Stroke Research: Vision and Opportunities. Stroke. 2017 09; 48(9):2632-2637. PMID: 28751554; PMCID: PMC5599159.
    Citations: 44     Fields:    Translation:HumansAnimals
  67. Charidimou A, Boulouis G, Gurol ME, Ayata C, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM. Emerging concepts in sporadic cerebral amyloid angiopathy. Brain. 2017 Jul 01; 140(7):1829-1850. PMID: 28334869; PMCID: PMC6059159.
    Citations: 113     Fields:    Translation:Humans
  68. Chen SP, Qin T, Seidel JL, Zheng Y, Eikermann M, Ferrari MD, van den Maagdenberg AMJM, Moskowitz MA, Ayata C, Eikermann-Haerter K. Inhibition of the P2X7-PANX1 complex suppresses spreading depolarization and neuroinflammation. Brain. 2017 Jun 01; 140(6):1643-1656. PMID: 28430869; PMCID: PMC7526725.
    Citations: 36     Fields:    Translation:HumansAnimals
  69. Khan S, Amin FM, Holtmannspötter M, Hansen K, Florescu AM, Fakhril-Din Z, Petersen JF, Ghanizada H, Ayata C, Gaist D, Ashina M. Endovascular thrombectomy and post-procedural headache. J Headache Pain. 2017 Dec; 18(1):10. PMID: 28130625; PMCID: PMC5272848.
    Citations: 2     Fields:    Translation:Humans
  70. Sun PZ, Ayata C, Lo EH. Fleeting footprints: finding MRI biomarkers of transient ischaemic attack. Brain. 2017 01; 140(1):8-10. PMID: 28031217.
    Citations: 2     Fields:    Translation:Humans
  71. Kim YS, Yoo A, Son JW, Kim HY, Lee YJ, Hwang S, Lee KY, Lee YJ, Ayata C, Kim HH, Koh SH. Early Activation of Phosphatidylinositol 3-Kinase after Ischemic Stroke Reduces Infarct Volume and Improves Long-Term Behavior. Mol Neurobiol. 2017 09; 54(7):5375-5384. PMID: 27590139.
    Citations: 8     Fields:    Translation:AnimalsCells
  72. Mandeville ET, Ayata C, Zheng Y, Mandeville JB. Translational MR Neuroimaging of Stroke and Recovery. Transl Stroke Res. 2017 02; 8(1):22-32. PMID: 27578048; PMCID: PMC5243530.
    Citations: 21     Fields:    Translation:HumansAnimals
  73. Boltze J, Ayata C. Challenges and Controversies in Translational Stroke Research - an Introduction. Transl Stroke Res. 2016 10; 7(5):355-7. PMID: 27581304.
    Citations: 11     Fields:    Translation:Humans
  74. Ayata C. Migraine: Treasure hunt in a minefield - exploring migraine with GWAS. Nat Rev Neurol. 2016 09; 12(9):496-8. PMID: 27539559.
    Citations: 2     Fields:    Translation:Humans
  75. Hoffmann U, Sheng H, Ayata C, Warner DS. Anesthesia in Experimental Stroke Research. Transl Stroke Res. 2016 10; 7(5):358-67. PMID: 27534542.
    Citations: 20     Fields:    Translation:HumansAnimals
  76. Chen SP, Ayata C. Spreading Depression in Primary and Secondary Headache Disorders. Curr Pain Headache Rep. 2016 Jul; 20(7):44. PMID: 27215627.
    Citations: 11     Fields:    Translation:Humans
  77. Boltze J, Wagner DC, Henninger N, Plesnila N, Ayata C. Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines. Transl Stroke Res. 2016 08; 7(4):241-7. PMID: 27297402; PMCID: PMC4927600.
    Citations: 16     Fields:    Translation:Humans
  78. Chung DY, Oka F, Ayata C. Spreading Depolarizations: A Therapeutic Target Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. J Clin Neurophysiol. 2016 Jun; 33(3):196-202. PMID: 27258442.
    Citations: 19     Fields:    Translation:Humans
  79. Singhal AB, Maas MB, Goldstein JN, Mills BB, Chen DW, Ayata C, Kacmarek RM, Topcuoglu MA. High-flow oxygen therapy for treatment of acute migraine: A randomized crossover trial. Cephalalgia. 2017 Jul; 37(8):730-736. PMID: 27206964.
    Citations: 4     Fields:    Translation:Humans
  80. Chen SP, Ay I, Lopes de Morais A, Qin T, Zheng Y, Sadeghian H, Oka F, Simon B, Eikermann-Haerter K, Ayata C. Vagus nerve stimulation inhibits cortical spreading depression. Pain. 2016 Apr; 157(4):797-805. PMID: 26645547; PMCID: PMC4943574.
    Citations: 41     Fields:    Translation:Animals
  81. Oka F, Hoffmann U, Lee JH, Shin HK, Chung DY, Yuzawa I, Chen SP, Atalay YB, Nozari A, Hopson KP, Qin T, Ayata C. Requisite ischemia for spreading depolarization occurrence after subarachnoid hemorrhage in rodents. J Cereb Blood Flow Metab. 2017 May; 37(5):1829-1840. PMID: 27432225; PMCID: PMC5435293.
    Citations: 15     Fields:    Translation:Animals
  82. Hartings JA, Shuttleworth CW, Kirov SA, Ayata C, Hinzman JM, Foreman B, Andrew RD, Boutelle MG, Brennan KC, Carlson AP, Dahlem MA, Drenckhahn C, Dohmen C, Fabricius M, Farkas E, Feuerstein D, Graf R, Helbok R, Lauritzen M, Major S, Oliveira-Ferreira AI, Richter F, Rosenthal ES, Sakowitz OW, Sánchez-Porras R, Santos E, Schöll M, Strong AJ, Urbach A, Westover MB, Winkler MK, Witte OW, Woitzik J, Dreier JP. The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão's legacy. J Cereb Blood Flow Metab. 2017 May; 37(5):1571-1594. PMID: 27328690; PMCID: PMC5435288.
    Citations: 126     Fields:    Translation:Humans
  83. Dreier JP, Fabricius M, Ayata C, Sakowitz OW, Shuttleworth CW, Dohmen C, Graf R, Vajkoczy P, Helbok R, Suzuki M, Schiefecker AJ, Major S, Winkler MK, Kang EJ, Milakara D, Oliveira-Ferreira AI, Reiffurth C, Revankar GS, Sugimoto K, Dengler NF, Hecht N, Foreman B, Feyen B, Kondziella D, Friberg CK, Piilgaard H, Rosenthal ES, Westover MB, Maslarova A, Santos E, Hertle D, Sánchez-Porras R, Jewell SL, Balança B, Platz J, Hinzman JM, Lückl J, Schoknecht K, Schöll M, Drenckhahn C, Feuerstein D, Eriksen N, Horst V, Bretz JS, Jahnke P, Scheel M, Bohner G, Rostrup E, Pakkenberg B, Heinemann U, Claassen J, Carlson AP, Kowoll CM, Lublinsky S, Chassidim Y, Shelef I, Friedman A, Brinker G, Reiner M, Kirov SA, Andrew RD, Farkas E, Güresir E, Vatter H, Chung LS, Brennan KC, Lieutaud T, Marinesco S, Maas AI, Sahuquillo J, Dahlem MA, Richter F, Herreras O, Boutelle MG, Okonkwo DO, Bullock MR, Witte OW, Martus P, van den Maagdenberg AM, Ferrari MD, Dijkhuizen RM, Shutter LA, Andaluz N, Schulte AP, MacVicar B, Watanabe T, Woitzik J, Lauritzen M, Strong AJ, Hartings JA. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group. J Cereb Blood Flow Metab. 2017 05; 37(5):1595-1625. PMID: 27317657; PMCID: PMC5435289.
    Citations: 111     Fields:    Translation:Humans
  84. Haerter F, Simons JC, Foerster U, Moreno Duarte I, Diaz-Gil D, Ganapati S, Eikermann-Haerter K, Ayata C, Zhang B, Blobner M, Isaacs L, Eikermann M. Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents. Anesthesiology. 2015 Dec; 123(6):1337-49. PMID: 26418697; PMCID: PMC4679413.
    Citations: 33     Fields:    Translation:Animals
  85. Mawet J, Eikermann-Haerter K, Park KY, Helenius J, Daneshmand A, Pearlman L, Avery R, Negro A, Velioglu M, Arsava EM, Ay H, Ayata C. Sensitivity to acute cerebral ischemic injury in migraineurs: A retrospective case-control study. Neurology. 2015 Dec 01; 85(22):1945-9. PMID: 26537055; PMCID: PMC4664124.
    Citations: 9     Fields:    Translation:Humans
  86. Seidel JL, Escartin C, Ayata C, Bonvento G, Shuttleworth CW. Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury? Glia. 2016 Jan; 64(1):5-20. PMID: 26301517.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  87. Srinivasan VJ, Yu E, Radhakrishnan H, Can A, Climov M, Leahy C, Ayata C, Eikermann-Haerter K. Micro-heterogeneity of flow in a mouse model of chronic cerebral hypoperfusion revealed by longitudinal Doppler optical coherence tomography and angiography. J Cereb Blood Flow Metab. 2015 Oct; 35(10):1552-60. PMID: 26243708; PMCID: PMC4640323.
    Citations: 16     Fields:    Translation:AnimalsCells
  88. Buckley EM, Miller BF, Golinski JM, Sadeghian H, McAllister LM, Vangel M, Ayata C, Meehan WP, Franceschini MA, Whalen MJ. Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice. J Cereb Blood Flow Metab. 2015 Dec; 35(12):1995-2000. PMID: 26154866; PMCID: PMC4671120.
    Citations: 19     Fields:    Translation:Animals
  89. Eikermann-Haerter K, Arbel-Ornath M, Yalcin N, Yu ES, Kuchibhotla KV, Yuzawa I, Hudry E, Willard CR, Climov M, Keles F, Belcher AM, Sengul B, Negro A, Rosen IA, Arreguin A, Ferrari MD, van den Maagdenberg AM, Bacskai BJ, Ayata C. Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. Ann Neurol. 2015 Aug; 78(2):193-210. PMID: 26032020; PMCID: PMC4515184.
    Citations: 17     Fields:    Translation:AnimalsCells
  90. Ayata C, Lauritzen M. Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiol Rev. 2015 Jul; 95(3):953-93. PMID: 26133935; PMCID: PMC4491545.
    Citations: 173     Fields:    Translation:HumansAnimalsCells
  91. Wilks MQ, Normandin MD, Yuan H, Cho H, Guo Y, Herisson F, Ayata C, Wooten DW, El Fakhri G, Josephson L. Imaging PEG-like nanoprobes in tumor, transient ischemia, and inflammatory disease models. Bioconjug Chem. 2015 Jun 17; 26(6):1061-9. PMID: 25971846; PMCID: PMC5378316.
    Citations: 3     Fields:    Translation:AnimalsCells
  92. Sakadžic S, Lee J, Boas DA, Ayata C. High-resolution in vivo optical imaging of stroke injury and repair. Brain Res. 2015 Oct 14; 1623:174-92. PMID: 25960347; PMCID: PMC4569527.
    Citations: 15     Fields:    Translation:Animals
  93. Blasi F, Herisson F, Wang S, Mao J, Ayata C. Late-onset thermal hypersensitivity after focal ischemic thalamic infarcts as a model for central post-stroke pain in rats. J Cereb Blood Flow Metab. 2015 Jul; 35(7):1100-3. PMID: 25899295; PMCID: PMC4640279.
    Citations: 6     Fields:    Translation:Animals
  94. von Bornstädt D, Houben T, Seidel JL, Zheng Y, Dilekoz E, Qin T, Sandow N, Kura S, Eikermann-Haerter K, Endres M, Boas DA, Moskowitz MA, Lo EH, Dreier JP, Woitzik J, Sakadžic S, Ayata C. Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations. Neuron. 2015 Mar 04; 85(5):1117-31. PMID: 25741731; PMCID: PMC4351476.
    Citations: 80     Fields:    Translation:HumansAnimals
  95. Chaparro RE, Izutsu M, Sasaki T, Sheng H, Zheng Y, Sadeghian H, Qin T, von Bornstadt D, Herisson F, Duan B, Li JS, Jiang K, Pearlstein M, Pearlstein RD, Smith DE, Goldberg ID, Ayata C, Warner DS. Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice. J Cereb Blood Flow Metab. 2015 Jun; 35(6):1044-53. PMID: 25712497; PMCID: PMC4640251.
    Citations: 9     Fields:    Translation:Animals
  96. Dilekoz E, Houben T, Eikermann-Haerter K, Balkaya M, Lenselink AM, Whalen MJ, Spijker S, Ferrari MD, van den Maagdenberg AM, Ayata C. Migraine mutations impair hippocampal learning despite enhanced long-term potentiation. J Neurosci. 2015 Feb 25; 35(8):3397-402. PMID: 25716839; PMCID: PMC4339352.
    Citations: 16     Fields:    Translation:Animals
  97. Blasi F, Whalen MJ, Ayata C. Lasting pure-motor deficits after focal posterior internal capsule white-matter infarcts in rats. J Cereb Blood Flow Metab. 2015 Jun; 35(6):977-84. PMID: 25649992; PMCID: PMC4640262.
    Citations: 12     Fields:    Translation:AnimalsCells
  98. Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf NA, Wang H, Silverman RB, Ayata C, Maxwell MM, Steegborn C, Schwarzschild MA, Outeiro TF, Kazantsev AG. The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. PLoS One. 2015; 10(1):e0116919. PMID: 25608039.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  99. Ferrari MD, Klever RR, Terwindt GM, Ayata C, van den Maagdenberg AM. Migraine pathophysiology: lessons from mouse models and human genetics. Lancet Neurol. 2015 Jan; 14(1):65-80. PMID: 25496898.
    Citations: 112     Fields:    Translation:HumansAnimals
  100. Diaz-Gil D, Mueller N, Moreno-Duarte I, Lin H, Ayata C, Cusin C, Cotten JF, Eikermann M. Etomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in Rats. Pharmaceuticals (Basel). 2014 Dec 29; 8(1):21-37. PMID: 25551398; PMCID: PMC4381199.
    Citations: 3     
  101. Sakadžic S, Mandeville ET, Gagnon L, Musacchia JJ, Yaseen MA, Yucel MA, Lefebvre J, Lesage F, Dale AM, Eikermann-Haerter K, Ayata C, Srinivasan VJ, Lo EH, Devor A, Boas DA. Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue. Nat Commun. 2014 Dec 08; 5:5734. PMID: 25483924.
    Citations: 86     Fields:    Translation:AnimalsCells
  102. Eikermann-Haerter K, Lee JH, Yalcin N, Yu ES, Daneshmand A, Wei Y, Zheng Y, Can A, Sengul B, Ferrari MD, van den Maagdenberg AM, Ayata C. Migraine prophylaxis, ischemic depolarizations, and stroke outcomes in mice. Stroke. 2015 Jan; 46(1):229-36. PMID: 25424478.
    Citations: 19     Fields:    Translation:Animals
  103. Shin HK, Oka F, Kim JH, Atochin D, Huang PL, Ayata C. Endothelial dysfunction abrogates the efficacy of normobaric hyperoxia in stroke. J Neurosci. 2014 Nov 12; 34(46):15200-7. PMID: 25392489; PMCID: PMC4228129.
    Citations: 9     Fields:    Translation:Animals
  104. Shyti R, Eikermann-Haerter K, van Heiningen SH, Meijer OC, Ayata C, Joëls M, Ferrari MD, van den Maagdenberg AM, Tolner EA. Stress hormone corticosterone enhances susceptibility to cortical spreading depression in familial hemiplegic migraine type 1 mutant mice. Exp Neurol. 2015 Jan; 263:214-20. PMID: 25447936.
    Citations: 15     Fields:    Translation:Animals
  105. Ebrahimkhani MR, Daneshmand A, Mazumder A, Allocca M, Calvo JA, Abolhassani N, Jhun I, Muthupalani S, Ayata C, Samson LD. Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):E4878-86. PMID: 25349415; PMCID: PMC4234618.
    Citations: 29     Fields:    Translation:AnimalsCells
  106. Mawet J, Kurth T, Ayata C. Migraine and stroke: in search of shared mechanisms. Cephalalgia. 2015 Feb; 35(2):165-81. PMID: 25228681.
    Citations: 27     Fields:    Translation:Humans
  107. Blasi F, Wei Y, Balkaya M, Tikka S, Mandeville JB, Waeber C, Ayata C, Moskowitz MA. Recognition memory impairments after subcortical white matter stroke in mice. Stroke. 2014 May; 45(5):1468-73. PMID: 24723319.
    Citations: 15     Fields:    Translation:Animals
  108. Lu L, Barfejani AH, Qin T, Dong Q, Ayata C, Waeber C. Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage. Brain Res. 2014 Mar 25; 1555:89-96. PMID: 24502984.
    Citations: 34     Fields:    Translation:Animals
  109. Boltze J, Ayata C, Wagner DC, Plesnila N. Preclinical phase III trials in translational stroke research: call for collective design of framework and guidelines. Stroke. 2014 Feb; 45(2):357. PMID: 24407954; PMCID: PMC3970114.
    Citations: 7     Fields:    Translation:Humans
  110. Lee JH, Zheng Y, von Bornstadt D, Wei Y, Balcioglu A, Daneshmand A, Yalcin N, Yu E, Herisson F, Atalay YB, Kim MH, Ahn YJ, Balkaya M, Sweetnam P, Schueller O, Poyurovsky MV, Kim HH, Lo EH, Furie KL, Ayata C. Selective ROCK2 Inhibition In Focal Cerebral Ischemia. Ann Clin Transl Neurol. 2014 Jan 01; 1(1):2-14. PMID: 24466563.
    Citations: 41     Fields:    
  111. Shin HK, Huang PL, Ayata C. Rho-kinase inhibition improves ischemic perfusion deficit in hyperlipidemic mice. J Cereb Blood Flow Metab. 2014 Feb; 34(2):284-7. PMID: 24192634.
    Citations: 12     Fields:    Translation:Animals
  112. Srinivasan VJ, Mandeville ET, Can A, Blasi F, Climov M, Daneshmand A, Lee JH, Yu E, Radhakrishnan H, Lo EH, Sakadžic S, Eikermann-Haerter K, Ayata C. Multiparametric, longitudinal optical coherence tomography imaging reveals acute injury and chronic recovery in experimental ischemic stroke. PLoS One. 2013; 8(8):e71478. PMID: 23940761.
    Citations: 40     Fields:    Translation:Animals
  113. Hoffmann U, Grosse-Sundrup M, Eikermann-Haerter K, Zaremba S, Ayata C, Zhang B, Ma D, Isaacs L, Eikermann M. Calabadion: A new agent to reverse the effects of benzylisoquinoline and steroidal neuromuscular-blocking agents. Anesthesiology. 2013 Aug; 119(2):317-25. PMID: 23549405.
    Citations: 28     Fields:    Translation:Animals
  114. Miyamoto N, Pham LD, Hayakawa K, Matsuzaki T, Seo JH, Magnain C, Ayata C, Kim KW, Boas D, Lo EH, Arai K. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke. 2013 Sep; 44(9):2573-8. PMID: 23881957.
    Citations: 50     Fields:    Translation:AnimalsCells
  115. Costa C, Tozzi A, Rainero I, Cupini LM, Calabresi P, Ayata C, Sarchielli P. Cortical spreading depression as a target for anti-migraine agents. J Headache Pain. 2013 Jul 23; 14:62. PMID: 23879550.
    Citations: 43     Fields:    Translation:Humans
  116. Ayata C. Pearls and pitfalls in experimental models of spreading depression. Cephalalgia. 2013 Jun; 33(8):604-13. PMID: 23671256.
    Citations: 30     Fields:    Translation:HumansAnimals
  117. Ayata C. Spreading depression and neurovascular coupling. Stroke. 2013 Jun; 44(6 Suppl 1):S87-9. PMID: 23709742.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  118. Ayata C, Shin HK, Dileköz E, Atochin DN, Kashiwagi S, Eikermann-Haerter K, Huang PL. Hyperlipidemia disrupts cerebrovascular reflexes and worsens ischemic perfusion defect. J Cereb Blood Flow Metab. 2013 Jun; 33(6):954-62. PMID: 23486293.
    Citations: 24     Fields:    Translation:AnimalsCells
  119. Koide M, Sukhotinsky I, Ayata C, Wellman GC. Subarachnoid hemorrhage, spreading depolarizations and impaired neurovascular coupling. Stroke Res Treat. 2013; 2013:819340. PMID: 23577279.
    Citations: 21     
  120. Dapul HR, Park J, Zhang J, Lee C, DanEshmand A, Lok J, Ayata C, Gray T, Scalzo A, Qiu J, Lo EH, Whalen MJ. Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in mice. J Neurotrauma. 2013 Mar 01; 30(5):382-91. PMID: 23153355.
    Citations: 7     Fields:    Translation:Animals
  121. Lee J, Radhakrishnan H, Wu W, Daneshmand A, Climov M, Ayata C, Boas DA. Quantitative imaging of cerebral blood flow velocity and intracellular motility using dynamic light scattering-optical coherence tomography. J Cereb Blood Flow Metab. 2013 Jun; 33(6):819-25. PMID: 23403378.
    Citations: 24     Fields:    Translation:AnimalsCells
  122. Seo JH, Miyamoto N, Hayakawa K, Pham LD, Maki T, Ayata C, Kim KW, Lo EH, Arai K. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest. 2013 Feb; 123(2):782-6. PMID: 23281396; PMCID: PMC3561802.
    Citations: 84     Fields:    Translation:AnimalsCells
  123. Eikermann-Haerter K, Negro A, Ayata C. Spreading depression and the clinical correlates of migraine. Rev Neurosci. 2013; 24(4):353-63. PMID: 23907418.
    Citations: 18     Fields:    Translation:HumansAnimals
  124. Hoffmann U, Ayata C. Neurovascular coupling during spreading depolarizations. Acta Neurochir Suppl. 2013; 115:161-5. PMID: 22890663.
    Citations: 12     Fields:    Translation:HumansAnimals
  125. Hoffmann U, Sukhotinsky I, Eikermann-Haerter K, Ayata C. Glucose modulation of spreading depression susceptibility. J Cereb Blood Flow Metab. 2013 Feb; 33(2):191-5. PMID: 22968322.
    Citations: 27     Fields:    Translation:Animals
  126. Hoffmann U, Sukhotinsky I, Atalay YB, Eikermann-Haerter K, Ayata C. Increased glucose availability does not restore prolonged spreading depression durations in hypotensive rats without brain injury. Exp Neurol. 2012 Dec; 238(2):130-2. PMID: 22981452.
    Citations: 7     Fields:    Translation:Animals
  127. Eikermann-Haerter K, Can A, Ayata C. Pharmacological targeting of spreading depression in migraine. Expert Rev Neurother. 2012 Mar; 12(3):297-306. PMID: 22364328.
    Citations: 11     Fields:    Translation:HumansAnimals
  128. Lee JH, Bacskai BJ, Ayata C. Genetic animal models of cerebral vasculopathies. Prog Mol Biol Transl Sci. 2012; 105:25-55. PMID: 22137428.
    Citations: 6     Fields:    Translation:HumansAnimals
  129. Eikermann-Haerter K, Lee JH, Yuzawa I, Liu CH, Zhou Z, Shin HK, Zheng Y, Qin T, Kurth T, Waeber C, Ferrari MD, van den Maagdenberg AM, Moskowitz MA, Ayata C. Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations. Circulation. 2012 Jan 17; 125(2):335-45. PMID: 22144569; PMCID: PMC3276214.
    Citations: 63     Fields:    Translation:Animals
  130. Garcia-Alloza M, Gregory J, Kuchibhotla KV, Fine S, Wei Y, Ayata C, Frosch MP, Greenberg SM, Bacskai BJ. Cerebrovascular lesions induce transient ß-amyloid deposition. Brain. 2011 Dec; 134(Pt 12):3697-707. PMID: 22120142; PMCID: PMC3235567.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  131. Yuzawa I, Sakadžic S, Srinivasan VJ, Shin HK, Eikermann-Haerter K, Boas DA, Ayata C. Cortical spreading depression impairs oxygen delivery and metabolism in mice. J Cereb Blood Flow Metab. 2012 Feb; 32(2):376-86. PMID: 22008729.
    Citations: 28     Fields:    Translation:Animals