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Ayata, Cenk
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Cenk Ayata, M.D.
Title
Professor of Neurology
Institution
Massachusetts General Hospital
Department
Neurology
Address
Massachusetts General Hospital
Room 6405, Neuroscience Center
149 13th Street
Charlestown MA 02129
Phone
617/726-0816
Fax
617/726-2547
vCard
Download vCard
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login for email
)
Other Positions
Title
Associate Professor of Radiology
Institution
Massachusetts General Hospital
Department
Radiology
research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R01NS115401
(SAKADZIC, SAVA)
May 1, 2020 - Apr 30, 2025
NIH
Investigating the microvascular mechanisms of O2 supply-demand mismatch in small vessel disease using novel high-resolution optical imaging
Role: Co-Principal Investigator
U01NS113443
(AYATA, CENK)
Sep 15, 2019 - Jul 31, 2022
NIH
Multicenter preclinical trial of rho-kinase inhibitor fasudil in acute focal cerebral ischemia and reperfusion
Role: Principal Investigator
R01NS102969
(AYATA, CENK)
Jul 15, 2017 - Apr 30, 2022
NIH
Non-invasive vagus nerve stimulation targeting cortical spreading depression in migrane prophylaxis
Role: Principal Investigator
R01NS061505
(AYATA, CENK)
Jan 15, 2008 - Dec 31, 2013
NIH
Neural & Vascular Dysfunction As Mechanisms of Injury in Genetic Migraine Models
Role: Principal Investigator
P01NS055104
(LO, ENG H.)
Jul 1, 2007 - Apr 30, 2020
NIH
Remodeling and recovery in the neurovascular unit
Role: Co-Principal Investigator
P50NS051343
(GREENBERG, STEVEN M)
Apr 1, 2005 - Jun 30, 2017
NIH
Specialized Programs of Translational Research in Acute Stroke at the Partners
Role: Co-Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Shin P,
Pian Q
, Ishikawa H,
Hamanaka G
,
Mandeville ET
, Shuzhen G, Buyin F, Alfadhel M, Allu SR, Sencan-Egilmez I, Li B,
Ran C
, Vinogradov SA,
Ayata C
,
Lo EH
, Arai K, Devor A, Sakadžic S. Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation. bioRxiv. 2023 Feb 13.
PMID:
36824939
; PMCID:
PMC9949059
.
Citations:
Morais A,
Locascio JJ
, Sansing LH, Lamb J, Nagarkatti K,
Imai T
,
van Leyen K
, Aronowski J, Koenig JI, Bosetti F, Lyden P,
Ayata C
. Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial. Stroke. 2023 Feb; 54(2):620-631.
PMID:
36601951
; PMCID:
PMC9870939
.
Citations:
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Animals
Sacco S,
Harriott AM
,
Ayata C
, Ornello R, Bagur R, Jimenez-Ruiz A, Sposato LA. Microembolism and Other Links Between Migraine and Stroke: Clinical and Pathophysiologic Update. Neurology. 2022 Dec 15.
PMID:
36522158
.
Citations:
Fields:
Neu
Neurology
Aykan SA
, Xie H, Zheng Y,
Chung DY
, Kura S, Han Lai J, Erdogan TD, Morais A, Tamim I, Yagmur D, Ishikawa H,
Arai K
, Abbas Yaseen M, Boas DA,
Sakadzic S
,
Ayata C
. Rho-Kinase Inhibition Improves the Outcome of Focal Subcortical White Matter Lesions. Stroke. 2022 07; 53(7):2369-2376.
PMID:
35656825
; PMCID:
PMC9245195
.
Citations:
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Humans
Animals
Oka F, Lee JH, Yuzawa I, Li M, von Bornstaedt D, Eikermann-Haerter K, Qin T,
Chung DY
, Sadeghian H, Seidel JL,
Imai T
, Vuralli D, Platt RM, Nelson MT, Joutel A,
Sakadzic S
,
Ayata C
. CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis. J Clin Invest. 2022 04 15; 132(8).
PMID:
35202003
; PMCID:
PMC9012276
.
Citations:
Fields:
Med
Medicine (General)
Translation:
Animals
Lai JH, Qin T, Sakadžic S,
Ayata C
,
Chung DY
. Correction to: Cortical Spreading Depolarizations in a Mouse Model of Subarachnoid Hemorrhage. Neurocrit Care. 2022 Apr; 36(2):689.
PMID:
35041114
.
Citations:
Fields:
Cri
Critical Care
Neu
Neurology
Lyden PD, Bosetti F, Diniz MA, Rogatko A, Koenig JI, Lamb J, Nagarkatti KA, Cabeen RP, Hess DC, Kamat PK, Khan MB, Wood K, Dhandapani K, Arbab AS, Leira EC, Chauhan AK, Dhanesha N, Patel RB, Kumskova M, Thedens D, Morais A,
Imai T
, Qin T,
Ayata C
, Boisserand LSB, Herman AL, Beatty HE, Velazquez SE, Diaz-Perez S, Sanganahalli BG, Mihailovic JM, Hyder F, Sansing LH, Koehler RC, Lannon S, Shi Y, Karuppagounder SS, Bibic A, Akhter K, Aronowski J, McCullough LD, Chauhan A, Goh A. The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results. Stroke. 2022 05; 53(5):1802-1812.
PMID:
35354299
; PMCID:
PMC9038686
.
Citations:
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Humans
Animals
Oka F, Sadeghian H, Yaseen MA, Fu B, Kura S, Qin T, Sakadžic S, Sugimoto K, Inoue T, Ishihara H, Nomura S, Suzuki M,
Ayata C
. Intracranial pressure spikes trigger spreading depolarizations. Brain. 2022 03 29; 145(1):194-207.
PMID:
34245240
; PMCID:
PMC9126007
.
Citations:
1
Fields:
Bra
Brain
Neu
Neurology
Translation:
Humans
Vuralli D, Arslan B, Topa E, de Morais AL, Gulbahar O,
Ayata C
, Bolay H. Migraine susceptibility is modulated by food triggers and analgesic overuse via sulfotransferase inhibition. J Headache Pain. 2022 Mar 14; 23(1):36.
PMID:
35282834
; PMCID:
PMC8919627
.
Citations:
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Humans
Animals
Andrew RD, Hartings JA,
Ayata C
, Brennan KC, Dawson-Scully KD, Farkas E, Herreras O, Kirov SA, Müller M, Ollen-Bittle N, Reiffurth C, Revah O, Robertson RM, Shuttleworth CW, Ullah G, Dreier JP. The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention. Neurocrit Care. 2022 06; 37(Suppl 1):83-101.
PMID:
35257321
; PMCID:
PMC9259543
.
Citations:
2
Fields:
Cri
Critical Care
Neu
Neurology
Translation:
Humans
Andrew RD, Farkas E, Hartings JA, Brennan KC, Herreras O, Müller M, Kirov SA,
Ayata C
, Ollen-Bittle N, Reiffurth C, Revah O, Robertson RM, Dawson-Scully KD, Ullah G, Dreier JP. Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization. Neurocrit Care. 2022 06; 37(Suppl 1):11-30.
PMID:
35194729
; PMCID:
PMC9259542
.
Citations:
1
Fields:
Cri
Critical Care
Neu
Neurology
Translation:
Humans
Liu TT, Morais A, Takizawa T, Mulder I, Simon BJ, Chen SP, Wang SJ,
Ayata C
, Yen JC. Efficacy profile of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model. J Headache Pain. 2022 Jan 21; 23(1):12.
PMID:
35062860
; PMCID:
PMC8903561
.
Citations:
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Animals
Ferrari MD, Goadsby PJ,
Burstein R
,
Kurth T
,
Ayata C
, Charles A, Ashina M, van den Maagdenberg AMJM, Dodick DW. Migraine. Nat Rev Dis Primers. 2022 01 13; 8(1):2.
PMID:
35027572
.
Citations:
3
Fields:
Med
Medicine (General)
Translation:
Humans
Lai JH, Qin T, Sakadžic S,
Ayata C
,
Chung DY
. Cortical Spreading Depolarizations in a Mouse Model of Subarachnoid Hemorrhage. Neurocrit Care. 2022 06; 37(Suppl 1):123-132.
PMID:
34981426
; PMCID:
PMC9250554
.
Citations:
Fields:
Cri
Critical Care
Neu
Neurology
Translation:
Animals
Aykan SA
, Xie H, Lai JH, Zheng Y,
Chung DY
, Kura S, Anzabi M, Sugimoto K, McAllister LM, Yaseen MA, Boas DA,
Whalen MJ
,
Sakadzic S
,
Ayata C
. Focal Subcortical White Matter Lesions Disrupt Resting State Cortical Interhemispheric Functional Connectivity in Mice. Cereb Cortex. 2021 10 01; 31(11):4958-4969.
PMID:
34037216
; PMCID:
PMC8491690
.
Citations:
1
Fields:
Bra
Brain
Translation:
Humans
Animals
Smith EE, Charidimou A,
Ayata C
, Werring DJ,
Greenberg SM
. Cerebral Amyloid Angiopathy-Related Transient Focal Neurologic Episodes. Neurology. 2021 08 03; 97(5):231-238.
PMID:
34016709
; PMCID:
PMC8356377
.
Citations:
1
Fields:
Neu
Neurology
Translation:
Humans
Tamim I,
Chung DY
, de Morais AL,
Loonen ICM
, Qin T, Misra A, Schlunk F, Endres M, Schiff SJ,
Ayata C
. Spreading depression as an innate antiseizure mechanism. Nat Commun. 2021 04 13; 12(1):2206.
PMID:
33850125
; PMCID:
PMC8044138
.
Citations:
5
Fields:
Bio
Biology
Sci
Science
Translation:
Animals
Anzabi M, Li B, Wang H, Kura S, Sakadžic S, Boas D, Østergaard L,
Ayata C
. Optical coherence tomography of arteriolar diameter and capillary perfusion during spreading depolarizations. J Cereb Blood Flow Metab. 2021 09; 41(9):2256-2263.
PMID:
33593116
; PMCID:
PMC8393288
.
Citations:
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Humans
Animals
Sugimoto K, Morais A, Sadeghian H, Qin T,
Chung DY
, Ashina M, Hougaard A,
Ayata C
. Intravascular Endothelin-1 does not trigger or increase susceptibility to Spreading Depolarizations. J Headache Pain. 2020 Oct 27; 21(1):127.
PMID:
33109086
.
Citations:
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Humans
Animals
Harriott AM
,
Chung DY
, Uner A, Bozdayi RO, Morais A, Takizawa T, Qin T,
Ayata C
. Optogenetic Spreading Depression Elicits Trigeminal Pain and Anxiety Behavior. Ann Neurol. 2021 01; 89(1):99-110.
PMID:
33016466
.
Citations:
10
Fields:
Neu
Neurology
Translation:
Animals
Fischer P, Sugimoto K,
Chung DY
, Tamim I, Morais A, Takizawa T, Qin T, Gomez CA, Schlunk F, Endres M, Yaseen MA,
Sakadzic S
,
Ayata C
. Rapid hematoma growth triggers spreading depolarizations in experimental intracortical hemorrhage. J Cereb Blood Flow Metab. 2021 06; 41(6):1264-1276.
PMID:
32936730
; PMCID:
PMC8142136
.
Citations:
2
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Chung DY
, Oka F, Jin G,
Harriott A
, Kura S,
Aykan SA
, Qin T, Edmiston WJ,
Lee H
, Yaseen MA, Sakadžic S, Boas DA,
Whalen MJ
,
Ayata C
. Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice. J Cereb Blood Flow Metab. 2021 05; 41(5):975-985.
PMID:
32936728
.
Citations:
7
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Yanagisawa T, Zhang H, Suzuki T, Kamio Y, Takizawa T, Morais A,
Chung DY
, Qin T, Murayama Y, Faber JE,
Patel AB
,
Ayata C
. Sex and Genetic Background Effects on the Outcome of Experimental Intracranial Aneurysms. Stroke. 2020 10; 51(10):3083-3094.
PMID:
32912097
.
Citations:
4
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Animals
Mulder IA, Li M, de Vries T, Qin T, Yanagisawa T, Sugimoto K, van den Bogaerdt A, Danser AHJ, Wermer MJH, van den Maagdenberg AMJM, MaassenVanDenBrink A, Ferrari MD,
Ayata C
. Anti-migraine Calcitonin Gene-Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice. Ann Neurol. 2020 10; 88(4):771-784.
PMID:
32583883
; PMCID:
PMC7540520
.
Citations:
16
Fields:
Neu
Neurology
Translation:
Humans
Animals
Sugimoto K,
Chung DY
, Böhm M, Fischer P, Takizawa T,
Aykan SA
, Qin T, Yanagisawa T,
Harriott A
, Oka F, Yaseen MA, Sakadžic S,
Ayata C
. Peri-Infarct Hot-Zones Have Higher Susceptibility to Optogenetic Functional Activation-Induced Spreading Depolarizations. Stroke. 2020 08; 51(8):2526-2535.
PMID:
32640946
.
Citations:
4
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Animals
Negro A, Seidel JL, Houben T, Yu ES, Rosen I, Arreguin AJ, Yalcin N, Shorser-Gentile L, Pearlman L, Sadhegian H, Vetrivelan R, Chamberlin NL,
Ayata C
, Martelletti P,
Moskowitz MA
, Eikermann-Haerter K. Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization. J Headache Pain. 2020 Jul 06; 21(1):86.
PMID:
32631251
.
Citations:
5
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Animals
Morais A, Liu TT, Qin T, Sadhegian H,
Ay I
, Yagmur D, Mendes da Silva R,
Chung D
, Simon B, Guedes R, Chen SP, Wang SJ, Yen JC,
Ayata C
. Vagus nerve stimulation inhibits cortical spreading depression exclusively through central mechanisms. Pain. 2020 07; 161(7):1661-1669.
PMID:
32142015
; PMCID:
PMC7305968
.
Citations:
10
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Animals
Takizawa T,
Ayata C
, Chen SP. Therapeutic implications of cortical spreading depression models in migraine. Prog Brain Res. 2020; 255:29-67.
PMID:
33008510
.
Citations:
4
Fields:
Bra
Brain
Translation:
Humans
Animals
Wuggenig P, Kaya B, Melhem H,
Ayata CK
, Hruz P, Sayan AE, Tsumura H, Ito M, Roux J, Niess JH. Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice. Commun Biol. 2020 03 18; 3(1):130.
PMID:
32188932
.
Citations:
8
Translation:
Humans
Animals
Cells
Shuttleworth CW, Andrew RD, Akbari Y,
Ayata C
, Balu R, Brennan KC, Boutelle M, Carlson AP, Dreier JP, Fabricius M, Farkas E, Foreman B, Helbok R, Henninger N, Jewell SL, Jones SC, Kirov SA, Lindquist BE, Maciel CB, Okonkwo D, Reinhart KM, Robertson RM,
Rosenthal ES
, Watanabe T, Hartings JA. Which Spreading Depolarizations Are Deleterious To Brain Tissue? Neurocrit Care. 2020 02; 32(1):317-322.
PMID:
31388871
; PMCID:
PMC7002178
.
Citations:
12
Fields:
Cri
Critical Care
Neu
Neurology
Translation:
Humans
Animals
Helbok R, Hartings JA, Schiefecker A, Balança B, Jewel S, Foreman B, Ercole A, Balu R,
Ayata C
, Ngwenya L, Rosenthal E, Boutelle MG, Farkas E, Dreier JP, Fabricius M, Shuttleworth CW, Carlson A. What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient? Neurocrit Care. 2020 02; 32(1):306-310.
PMID:
31338747
; PMCID:
PMC6980932
.
Citations:
8
Fields:
Cri
Critical Care
Neu
Neurology
Translation:
Humans
Oka F,
Chung DY
, Suzuki M,
Ayata C
. Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental-Clinical Disconnect and the Unmet Need. Neurocrit Care. 2020 02; 32(1):238-251.
PMID:
30671784
; PMCID:
PMC7387950
.
Citations:
11
Fields:
Cri
Critical Care
Neu
Neurology
Translation:
Animals
Hougaard A, Younis S, Iljazi A, Sugimoto K,
Ayata C
, Ashina M. Intravenous Endothelin-1 Infusion Does Not Induce Aura or Headache in Migraine Patients With Aura. Headache. 2020 04; 60(4):724-734.
PMID:
31994720
.
Citations:
5
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Humans
Schulien I, Hockenjos B, van Marck V,
Ayata CK
, Follo M, Thimme R, Hasselblatt P. Extracellular ATP and Purinergic P2Y2 Receptor Signaling Promote Liver Tumorigenesis in Mice by Exacerbating DNA Damage. Cancer Res. 2020 02 15; 80(4):699-708.
PMID:
31822494
.
Citations:
12
Fields:
Neo
Neoplasms
Translation:
Animals
Cells
Chen X, Sobczak F, Chen Y,
Jiang Y
, Qian C, Lu Z,
Ayata C
, Logothetis NK,
Yu X
. Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus. Nat Commun. 2019 11 20; 10(1):5239.
PMID:
31748553
; PMCID:
PMC6868210
.
Citations:
20
Fields:
Bio
Biology
Sci
Science
Translation:
Animals
Cells
Harriott AM
, Karakaya F,
Ayata C
. Headache after ischemic stroke: A systematic review and meta-analysis. Neurology. 2020 01 07; 94(1):e75-e86.
PMID:
31694924
.
Citations:
8
Fields:
Neu
Neurology
Translation:
Humans
Hougaard A, Younis S, Iljazi A, Haanes KA, Lindberg U, Vestergaard MB, Amin FM, Sugimoto K, Kruse LS,
Ayata C
, Ashina M. Cerebrovascular effects of endothelin-1 investigated using high-resolution magnetic resonance imaging in healthy volunteers. J Cereb Blood Flow Metab. 2020 08; 40(8):1685-1694.
PMID:
31500524
.
Citations:
5
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Humans
Shvedova M
, Litvak MM,
Roberts JD
,
Fukumura D
, Suzuki T, Sencan I, Li G, Reventun P, Buys ES, Kim HH, Sakadžic S,
Ayata C
,
Huang PL
, Feil R,
Atochin DN
. cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice. J Cereb Blood Flow Metab. 2019 12; 39(12):2379-2391.
PMID:
31423931
.
Citations:
2
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Cells
Balkaya M, Seidel JL, Sadeghian H, Qin T,
Chung DY
, Eikermann-Haerter K, van den Maagdenberg AMJM, Ferrari MD,
Ayata C
. Relief Following Chronic Stress Augments Spreading Depolarization Susceptibility in Familial Hemiplegic Migraine Mice. Neuroscience. 2019 09 01; 415:1-9.
PMID:
31299346
.
Citations:
2
Fields:
Neu
Neurology
Translation:
Animals
Takizawa T, Qin T, Lopes de Morais A, Sugimoto K, Chung JY, Morsett L, Mulder I, Fischer P, Suzuki T, Anzabi M, Böhm M, Qu WS, Yanagisawa T, Hickman S, Khoury JE,
Whalen MJ
,
Harriott AM
,
Chung DY
,
Ayata C
. Non-invasively triggered spreading depolarizations induce a rapid pro-inflammatory response in cerebral cortex. J Cereb Blood Flow Metab. 2020 05; 40(5):1117-1131.
PMID:
31242047
.
Citations:
20
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Radulovic K,
Ayata CK
, Mak'Anyengo R, Lechner K, Wuggenig P, Kaya B, Hruz P, Gomez de Agüero M, Broz P, Weigmann B, Niess JH. NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death. J Immunol. 2019 07 15; 203(2):544-556.
PMID:
31152078
.
Citations:
4
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Regenhardt RW
,
Das AS
, Ohtomo R,
Lo EH
,
Ayata C
,
Gurol ME
. Pathophysiology of Lacunar Stroke: History's Mysteries and Modern Interpretations. J Stroke Cerebrovasc Dis. 2019 Aug; 28(8):2079-2097.
PMID:
31151839
.
Citations:
12
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Humans
Animals
Xie H,
Chung DY
, Kura S, Sugimoto K,
Aykan SA
, Wu Y, Sakadžic S, Yaseen MA, Boas DA,
Ayata C
. Differential effects of anesthetics on resting state functional connectivity in the mouse. J Cereb Blood Flow Metab. 2020 04; 40(4):875-884.
PMID:
31092086
.
Citations:
12
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Böhm M,
Chung DY
, Gómez CA, Qin T, Takizawa T, Sadeghian H, Sugimoto K, Sakadžic S, Yaseen MA,
Ayata C
. Neurovascular coupling during optogenetic functional activation: Local and remote stimulus-response characteristics, and uncoupling by spreading depression. J Cereb Blood Flow Metab. 2020 04; 40(4):808-822.
PMID:
31063009
.
Citations:
6
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Schlunk F, Böhm M, Boulouis G, Qin T, Arbel M, Tamim I, Fischer P,
Bacskai BJ
,
Frosch MP
, Endres M,
Greenberg SM
,
Ayata C
. Secondary Bleeding During Acute Experimental Intracerebral Hemorrhage. Stroke. 2019 05; 50(5):1210-1215.
PMID:
31009358
; PMCID:
PMC6478448
.
Citations:
4
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Animals
Suzuki T, Takizawa T, Kamio Y, Qin T, Hashimoto T, Fujii Y, Murayama Y,
Patel AB
,
Ayata C
. Noninvasive Vagus Nerve Stimulation Prevents Ruptures and Improves Outcomes in a Model of Intracranial Aneurysm in Mice. Stroke. 2019 05; 50(5):1216-1223.
PMID:
30943885
; PMCID:
PMC6476688
.
Citations:
5
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Animals
Ashina M,
Ayata C
. Neurovascular origin of primary headaches. J Cereb Blood Flow Metab. 2019 04; 39(4):571-572.
PMID:
30929598
; PMCID:
PMC6446421
.
Citations:
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Humans
Chung DY
, Sadeghian H, Qin T, Lule S,
Lee H
, Karakaya F, Goins S, Oka F, Yaseen MA, Houben T, Tolner EA, van den Maagdenberg AMJM,
Whalen MJ
, Sakadžic S,
Ayata C
. Determinants of Optogenetic Cortical Spreading Depolarizations. Cereb Cortex. 2019 03 01; 29(3):1150-1161.
PMID:
29425263
.
Citations:
15
Fields:
Bra
Brain
Translation:
Animals
Cells
Vuralli D,
Ayata C
, Bolay H. Cognitive dysfunction and migraine. J Headache Pain. 2018 Nov 15; 19(1):109.
PMID:
30442090
; PMCID:
PMC6755588
.
Citations:
34
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Humans
Chung DY
, Sugimoto K, Fischer P, Böhm M, Takizawa T, Sadeghian H, Morais A,
Harriott A
, Oka F, Qin T, Henninger N, Yaseen MA, Sakadžic S,
Ayata C
. Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice. J Neurosci Methods. 2018 11 01; 309:143-146.
PMID:
30194041
; PMCID:
PMC6214472
.
Citations:
15
Fields:
Neu
Neurology
Translation:
Animals
Sadeghian H, Lacoste B, Qin T, Toussay X, Rosa R, Oka F,
Chung DY
, Takizawa T, Gu C,
Ayata C
. Spreading depolarizations trigger caveolin-1-dependent endothelial transcytosis. Ann Neurol. 2018 09; 84(3):409-423.
PMID:
30014540
.
Citations:
33
Fields:
Neu
Neurology
Translation:
Animals
Cells
Bouley J,
Chung DY
,
Ayata C
, Brown RH, Henninger N. Cortical Spreading Depression Denotes Concussion Injury. J Neurotrauma. 2019 04 01; 36(7):1008-1017.
PMID:
29999455
; PMCID:
PMC6444888
.
Citations:
14
Fields:
Neu
Neurology
Tra
Traumatology
Translation:
Animals
Ayata C
. Monitoring anoxic depolarization at the bedside: A step closer to the 24th century. J Cereb Blood Flow Metab. 2018 07; 38(7):1123-1124.
PMID:
29961421
; PMCID:
PMC6434453
.
Citations:
3
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Humans
Rosenthal ES
, Biswal S,
Zafar SF
, O'Connor KL,
Bechek S
, Shenoy AV, Boyle EJ,
Shafi MM
, Gilmore EJ, Foreman BP, Gaspard N, Leslie-Mazwi TM,
Rosand J
,
Hoch DB
,
Ayata C
,
Cash SS
,
Cole AJ
,
Patel AB
,
Westover MB
. Continuous electroencephalography predicts delayed cerebral ischemia after subarachnoid hemorrhage: A prospective study of diagnostic accuracy. Ann Neurol. 2018 05; 83(5):958-969.
PMID:
29659050
; PMCID:
PMC6021198
.
Citations:
23
Fields:
Neu
Neurology
Translation:
Humans
Akhter M, Qin T, Fischer P, Sadeghian H, Kim HH,
Whalen MJ
,
Goldstein JN
,
Ayata C
. Rho-kinase inhibitors do not expand hematoma volume in acute experimental intracerebral hemorrhage. Ann Clin Transl Neurol. 2018 Jun; 5(6):769-776.
PMID:
29928660
.
Citations:
4
Fields:
Neu
Neurology
Lan J,
Esposito E
,
Ayata C
,
Singhal AB
,
Lo EH
, Ji X. Different Effects of Normobaric Oxygen in Normotensive Versus Hypertensive Rats After Focal Cerebral Ischemia. Stroke. 2018 06; 49(6):1534-1537.
PMID:
29712880
.
Citations:
5
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Animals
Xie H, Yu K, Zhou N, Shen X, Tian S, Zhang B, Wang Y, Wu J, Liu G, Jiang C, Hu R,
Ayata C
, Wu Y. Enriched Environment Elicits Proangiogenic Mechanisms After Focal Cerebral Ischemia. Transl Stroke Res. 2019 04; 10(2):150-159.
PMID:
29700717
.
Citations:
7
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
Yalcin N, Chen SP, Yu ES, Liu TT, Yen JC, Atalay YB, Qin T, Celik F, van den Maagdenberg AM,
Moskowitz MA
,
Ayata C
, Eikermann-Haerter K. Caffeine does not affect susceptibility to cortical spreading depolarization in mice. J Cereb Blood Flow Metab. 2019 04; 39(4):740-750.
PMID:
29651899
; PMCID:
PMC6446422
.
Citations:
6
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Bix GJ, Fraser JF, Mack WJ, Carmichael ST, Perez-Pinzon M, Offner H, Sansing L, Bosetti F,
Ayata C
, Pennypacker KR. Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical. Transl Stroke Res. 2018 06; 9(3):258-266.
PMID:
29633156
; PMCID:
PMC5982459
.
Citations:
6
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Humans
Animals
Iljazi A,
Ayata C
, Ashina M, Hougaard A. The Role of Endothelin in the Pathophysiology of Migraine-a Systematic Review. Curr Pain Headache Rep. 2018 Mar 19; 22(4):27.
PMID:
29557064
.
Citations:
11
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Humans
Animals
Waddington DEJ, Sarracanie M, Salameh N, Herisson F,
Ayata C
,
Rosen MS
. An Overhauser-enhanced-MRI platform for dynamic free radical imaging in vivo. NMR Biomed. 2018 05; 31(5):e3896.
PMID:
29493032
.
Citations:
4
Fields:
Dia
Diagnostic Imaging
Nuc
Nuclear Medicine
Translation:
Animals
Kura S, Xie H, Fu B,
Ayata C
, Boas DA, Sakadžic S. Intrinsic optical signal imaging of the blood volume changes is sufficient for mapping the resting state functional connectivity in the rodent cortex. J Neural Eng. 2018 06; 15(3):035003.
PMID:
29451130
.
Citations:
15
Fields:
Bio
Biomedical Engineering
Neu
Neurology
Translation:
Animals
Liebeskind DS,
Ayata C
, Brown S, Raychev R, Scalzo F, Broderick JP, Tomsick TA, Cipolla MJ. Abstract 79: Chronic and Acute Hypertension in Ischemic Stroke Are Distinct Markers of Impaired Collateral Circulation. Stroke. 2018 Jan 22; 49(Suppl_1):A79.
PMID:
30520353
.
Citations:
Fields:
Bra
Brain
Vas
Vascular Diseases
Herisson F, Zhou I, Mawet J, Du E, Barfejani AH, Qin T, Cipolla MJ, Sun PZ,
Rost NS
,
Ayata C
. Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet. J Cereb Blood Flow Metab. 2019 07; 39(7):1232-1246.
PMID:
29350576
; PMCID:
PMC6668522
.
Citations:
4
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Humans
Animals
Chen SP,
Ayata C
. Novel Therapeutic Targets Against Spreading Depression. Headache. 2017 Oct; 57(9):1340-1358.
PMID:
28842982
.
Citations:
7
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Humans
Animals
Bosetti F, Koenig JI,
Ayata C
, Back SA, Becker K, Broderick JP, Carmichael ST, Cho S, Cipolla MJ, Corbett D, Corriveau RA, Cramer SC, Ferguson AR,
Finklestein SP
, Ford BD, Furie KL, Hemmen TM, Iadecola C, Jakeman LB, Janis S, Jauch EC, Johnston KC, Kochanek PM, Kohn H,
Lo EH
, Lyden PD, Mallard C, McCullough LD, McGavern LM, Meschia JF, Moy CS, Perez-Pinzon MA, Ramadan I, Savitz SI,
Schwamm LH
, Steinberg GK, Stenzel-Poore MP, Tymianski M, Warach S, Wechsler LR, Zhang JH, Koroshetz W. Translational Stroke Research: Vision and Opportunities. Stroke. 2017 09; 48(9):2632-2637.
PMID:
28751554
; PMCID:
PMC5599159
.
Citations:
44
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Humans
Animals
Charidimou A, Boulouis G,
Gurol ME
,
Ayata C
,
Bacskai BJ
,
Frosch MP
,
Viswanathan A
,
Greenberg SM
. Emerging concepts in sporadic cerebral amyloid angiopathy. Brain. 2017 Jul 01; 140(7):1829-1850.
PMID:
28334869
; PMCID:
PMC6059159
.
Citations:
113
Fields:
Bra
Brain
Neu
Neurology
Translation:
Humans
Chen SP, Qin T, Seidel JL, Zheng Y, Eikermann M, Ferrari MD, van den Maagdenberg AMJM,
Moskowitz MA
,
Ayata C
, Eikermann-Haerter K. Inhibition of the P2X7-PANX1 complex suppresses spreading depolarization and neuroinflammation. Brain. 2017 Jun 01; 140(6):1643-1656.
PMID:
28430869
; PMCID:
PMC7526725
.
Citations:
36
Fields:
Bra
Brain
Neu
Neurology
Translation:
Humans
Animals
Khan S, Amin FM, Holtmannspötter M, Hansen K, Florescu AM, Fakhril-Din Z, Petersen JF, Ghanizada H,
Ayata C
, Gaist D, Ashina M. Endovascular thrombectomy and post-procedural headache. J Headache Pain. 2017 Dec; 18(1):10.
PMID:
28130625
; PMCID:
PMC5272848
.
Citations:
2
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Humans
Sun PZ,
Ayata C
,
Lo EH
. Fleeting footprints: finding MRI biomarkers of transient ischaemic attack. Brain. 2017 01; 140(1):8-10.
PMID:
28031217
.
Citations:
2
Fields:
Bra
Brain
Neu
Neurology
Translation:
Humans
Kim YS, Yoo A, Son JW, Kim HY, Lee YJ, Hwang S, Lee KY, Lee YJ,
Ayata C
, Kim HH, Koh SH. Early Activation of Phosphatidylinositol 3-Kinase after Ischemic Stroke Reduces Infarct Volume and Improves Long-Term Behavior. Mol Neurobiol. 2017 09; 54(7):5375-5384.
PMID:
27590139
.
Citations:
8
Fields:
Mol
Molecular Biology
Neu
Neurology
Translation:
Animals
Cells
Mandeville ET
,
Ayata C
, Zheng Y,
Mandeville JB
. Translational MR Neuroimaging of Stroke and Recovery. Transl Stroke Res. 2017 02; 8(1):22-32.
PMID:
27578048
; PMCID:
PMC5243530
.
Citations:
21
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Humans
Animals
Boltze J,
Ayata C
. Challenges and Controversies in Translational Stroke Research - an Introduction. Transl Stroke Res. 2016 10; 7(5):355-7.
PMID:
27581304
.
Citations:
11
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Humans
Ayata C
. Migraine: Treasure hunt in a minefield - exploring migraine with GWAS. Nat Rev Neurol. 2016 09; 12(9):496-8.
PMID:
27539559
.
Citations:
2
Fields:
Neu
Neurology
Translation:
Humans
Hoffmann U, Sheng H,
Ayata C
, Warner DS. Anesthesia in Experimental Stroke Research. Transl Stroke Res. 2016 10; 7(5):358-67.
PMID:
27534542
.
Citations:
20
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Humans
Animals
Chen SP,
Ayata C
. Spreading Depression in Primary and Secondary Headache Disorders. Curr Pain Headache Rep. 2016 Jul; 20(7):44.
PMID:
27215627
.
Citations:
11
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Humans
Boltze J, Wagner DC, Henninger N, Plesnila N,
Ayata C
. Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines. Transl Stroke Res. 2016 08; 7(4):241-7.
PMID:
27297402
; PMCID:
PMC4927600
.
Citations:
16
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Humans
Chung DY
, Oka F,
Ayata C
. Spreading Depolarizations: A Therapeutic Target Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. J Clin Neurophysiol. 2016 Jun; 33(3):196-202.
PMID:
27258442
.
Citations:
19
Fields:
Neu
Neurology
Phy
Physiology
Translation:
Humans
Singhal AB
, Maas MB,
Goldstein JN
, Mills BB, Chen DW,
Ayata C
, Kacmarek RM, Topcuoglu MA. High-flow oxygen therapy for treatment of acute migraine: A randomized crossover trial. Cephalalgia. 2017 Jul; 37(8):730-736.
PMID:
27206964
.
Citations:
4
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Humans
Chen SP,
Ay I
, Lopes de Morais A, Qin T, Zheng Y, Sadeghian H, Oka F, Simon B, Eikermann-Haerter K,
Ayata C
. Vagus nerve stimulation inhibits cortical spreading depression. Pain. 2016 Apr; 157(4):797-805.
PMID:
26645547
; PMCID:
PMC4943574
.
Citations:
41
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Animals
Oka F, Hoffmann U, Lee JH, Shin HK,
Chung DY
, Yuzawa I, Chen SP, Atalay YB, Nozari A, Hopson KP, Qin T,
Ayata C
. Requisite ischemia for spreading depolarization occurrence after subarachnoid hemorrhage in rodents. J Cereb Blood Flow Metab. 2017 May; 37(5):1829-1840.
PMID:
27432225
; PMCID:
PMC5435293
.
Citations:
15
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Hartings JA, Shuttleworth CW, Kirov SA,
Ayata C
, Hinzman JM, Foreman B, Andrew RD, Boutelle MG, Brennan KC, Carlson AP, Dahlem MA, Drenckhahn C, Dohmen C, Fabricius M, Farkas E, Feuerstein D, Graf R, Helbok R, Lauritzen M, Major S, Oliveira-Ferreira AI, Richter F,
Rosenthal ES
, Sakowitz OW, Sánchez-Porras R, Santos E, Schöll M, Strong AJ, Urbach A,
Westover MB
, Winkler MK, Witte OW, Woitzik J, Dreier JP. The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão's legacy. J Cereb Blood Flow Metab. 2017 May; 37(5):1571-1594.
PMID:
27328690
; PMCID:
PMC5435288
.
Citations:
126
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Humans
Dreier JP, Fabricius M,
Ayata C
, Sakowitz OW, Shuttleworth CW, Dohmen C, Graf R, Vajkoczy P, Helbok R, Suzuki M, Schiefecker AJ, Major S, Winkler MK, Kang EJ, Milakara D, Oliveira-Ferreira AI, Reiffurth C, Revankar GS, Sugimoto K, Dengler NF, Hecht N, Foreman B, Feyen B, Kondziella D, Friberg CK, Piilgaard H,
Rosenthal ES
,
Westover MB
, Maslarova A, Santos E, Hertle D, Sánchez-Porras R, Jewell SL, Balança B, Platz J, Hinzman JM, Lückl J, Schoknecht K, Schöll M, Drenckhahn C, Feuerstein D, Eriksen N, Horst V, Bretz JS, Jahnke P, Scheel M, Bohner G, Rostrup E, Pakkenberg B, Heinemann U, Claassen J, Carlson AP, Kowoll CM, Lublinsky S, Chassidim Y, Shelef I, Friedman A, Brinker G, Reiner M, Kirov SA, Andrew RD, Farkas E, Güresir E, Vatter H, Chung LS, Brennan KC, Lieutaud T, Marinesco S, Maas AI, Sahuquillo J, Dahlem MA, Richter F, Herreras O, Boutelle MG, Okonkwo DO, Bullock MR, Witte OW, Martus P, van den Maagdenberg AM, Ferrari MD, Dijkhuizen RM, Shutter LA, Andaluz N, Schulte AP, MacVicar B, Watanabe T, Woitzik J, Lauritzen M, Strong AJ, Hartings JA. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group. J Cereb Blood Flow Metab. 2017 05; 37(5):1595-1625.
PMID:
27317657
; PMCID:
PMC5435289
.
Citations:
111
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Humans
Haerter F, Simons JC, Foerster U, Moreno Duarte I,
Diaz-Gil D
, Ganapati S, Eikermann-Haerter K,
Ayata C
, Zhang B, Blobner M, Isaacs L, Eikermann M. Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents. Anesthesiology. 2015 Dec; 123(6):1337-49.
PMID:
26418697
; PMCID:
PMC4679413
.
Citations:
33
Fields:
Ane
Anesthesiology
Translation:
Animals
Mawet J, Eikermann-Haerter K, Park KY, Helenius J, Daneshmand A, Pearlman L, Avery R, Negro A, Velioglu M, Arsava EM,
Ay H
,
Ayata C
. Sensitivity to acute cerebral ischemic injury in migraineurs: A retrospective case-control study. Neurology. 2015 Dec 01; 85(22):1945-9.
PMID:
26537055
; PMCID:
PMC4664124
.
Citations:
9
Fields:
Neu
Neurology
Translation:
Humans
Seidel JL, Escartin C,
Ayata C
, Bonvento G, Shuttleworth CW. Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury? Glia. 2016 Jan; 64(1):5-20.
PMID:
26301517
.
Citations:
28
Fields:
Neu
Neurology
Translation:
Humans
Animals
Cells
Srinivasan VJ, Yu E, Radhakrishnan H, Can A, Climov M, Leahy C,
Ayata C
, Eikermann-Haerter K. Micro-heterogeneity of flow in a mouse model of chronic cerebral hypoperfusion revealed by longitudinal Doppler optical coherence tomography and angiography. J Cereb Blood Flow Metab. 2015 Oct; 35(10):1552-60.
PMID:
26243708
; PMCID:
PMC4640323
.
Citations:
16
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Cells
Buckley EM, Miller BF, Golinski JM, Sadeghian H, McAllister LM,
Vangel M
,
Ayata C
,
Meehan WP
,
Franceschini MA
,
Whalen MJ
. Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice. J Cereb Blood Flow Metab. 2015 Dec; 35(12):1995-2000.
PMID:
26154866
; PMCID:
PMC4671120
.
Citations:
19
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Eikermann-Haerter K, Arbel-Ornath M, Yalcin N, Yu ES, Kuchibhotla KV, Yuzawa I, Hudry E, Willard CR, Climov M, Keles F, Belcher AM, Sengul B, Negro A, Rosen IA, Arreguin A, Ferrari MD, van den Maagdenberg AM,
Bacskai BJ
,
Ayata C
. Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. Ann Neurol. 2015 Aug; 78(2):193-210.
PMID:
26032020
; PMCID:
PMC4515184
.
Citations:
17
Fields:
Neu
Neurology
Translation:
Animals
Cells
Ayata C
, Lauritzen M. Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiol Rev. 2015 Jul; 95(3):953-93.
PMID:
26133935
; PMCID:
PMC4491545
.
Citations:
173
Fields:
Phy
Physiology
Translation:
Humans
Animals
Cells
Wilks MQ
,
Normandin MD
,
Yuan H
, Cho H, Guo Y, Herisson F,
Ayata C
,
Wooten DW
,
El Fakhri G
,
Josephson L
. Imaging PEG-like nanoprobes in tumor, transient ischemia, and inflammatory disease models. Bioconjug Chem. 2015 Jun 17; 26(6):1061-9.
PMID:
25971846
; PMCID:
PMC5378316
.
Citations:
3
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Sakadžic S, Lee J, Boas DA,
Ayata C
. High-resolution in vivo optical imaging of stroke injury and repair. Brain Res. 2015 Oct 14; 1623:174-92.
PMID:
25960347
; PMCID:
PMC4569527
.
Citations:
15
Fields:
Bra
Brain
Translation:
Animals
Blasi F, Herisson F, Wang S,
Mao J
,
Ayata C
. Late-onset thermal hypersensitivity after focal ischemic thalamic infarcts as a model for central post-stroke pain in rats. J Cereb Blood Flow Metab. 2015 Jul; 35(7):1100-3.
PMID:
25899295
; PMCID:
PMC4640279
.
Citations:
6
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
von Bornstädt D, Houben T, Seidel JL, Zheng Y, Dilekoz E, Qin T, Sandow N, Kura S, Eikermann-Haerter K, Endres M, Boas DA,
Moskowitz MA
,
Lo EH
, Dreier JP, Woitzik J, Sakadžic S,
Ayata C
. Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations. Neuron. 2015 Mar 04; 85(5):1117-31.
PMID:
25741731
; PMCID:
PMC4351476
.
Citations:
80
Fields:
Neu
Neurology
Translation:
Humans
Animals
Chaparro RE, Izutsu M, Sasaki T, Sheng H, Zheng Y, Sadeghian H, Qin T, von Bornstadt D, Herisson F, Duan B, Li JS, Jiang K, Pearlstein M, Pearlstein RD, Smith DE, Goldberg ID,
Ayata C
, Warner DS. Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice. J Cereb Blood Flow Metab. 2015 Jun; 35(6):1044-53.
PMID:
25712497
; PMCID:
PMC4640251
.
Citations:
9
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Dilekoz E, Houben T, Eikermann-Haerter K, Balkaya M, Lenselink AM,
Whalen MJ
, Spijker S, Ferrari MD, van den Maagdenberg AM,
Ayata C
. Migraine mutations impair hippocampal learning despite enhanced long-term potentiation. J Neurosci. 2015 Feb 25; 35(8):3397-402.
PMID:
25716839
; PMCID:
PMC4339352
.
Citations:
16
Fields:
Neu
Neurology
Translation:
Animals
Blasi F,
Whalen MJ
,
Ayata C
. Lasting pure-motor deficits after focal posterior internal capsule white-matter infarcts in rats. J Cereb Blood Flow Metab. 2015 Jun; 35(6):977-84.
PMID:
25649992
; PMCID:
PMC4640262
.
Citations:
12
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Cells
Chen X, Wales P,
Quinti L
, Zuo F, Moniot S, Herisson F, Rauf NA, Wang H, Silverman RB,
Ayata C
, Maxwell MM, Steegborn C,
Schwarzschild MA
, Outeiro TF, Kazantsev AG. The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. PLoS One. 2015; 10(1):e0116919.
PMID:
25608039
.
Citations:
51
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Ferrari MD, Klever RR, Terwindt GM,
Ayata C
, van den Maagdenberg AM. Migraine pathophysiology: lessons from mouse models and human genetics. Lancet Neurol. 2015 Jan; 14(1):65-80.
PMID:
25496898
.
Citations:
112
Fields:
Neu
Neurology
Translation:
Humans
Animals
Diaz-Gil D
, Mueller N, Moreno-Duarte I, Lin H,
Ayata C
,
Cusin C
,
Cotten JF
, Eikermann M. Etomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in Rats. Pharmaceuticals (Basel). 2014 Dec 29; 8(1):21-37.
PMID:
25551398
; PMCID:
PMC4381199
.
Citations:
3
Sakadžic S,
Mandeville ET
, Gagnon L, Musacchia JJ, Yaseen MA, Yucel MA, Lefebvre J, Lesage F, Dale AM, Eikermann-Haerter K,
Ayata C
, Srinivasan VJ,
Lo EH
, Devor A, Boas DA. Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue. Nat Commun. 2014 Dec 08; 5:5734.
PMID:
25483924
.
Citations:
86
Fields:
Bio
Biology
Sci
Science
Translation:
Animals
Cells
Eikermann-Haerter K, Lee JH, Yalcin N, Yu ES, Daneshmand A, Wei Y, Zheng Y, Can A, Sengul B, Ferrari MD, van den Maagdenberg AM,
Ayata C
. Migraine prophylaxis, ischemic depolarizations, and stroke outcomes in mice. Stroke. 2015 Jan; 46(1):229-36.
PMID:
25424478
.
Citations:
19
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Animals
Shin HK, Oka F, Kim JH,
Atochin D
,
Huang PL
,
Ayata C
. Endothelial dysfunction abrogates the efficacy of normobaric hyperoxia in stroke. J Neurosci. 2014 Nov 12; 34(46):15200-7.
PMID:
25392489
; PMCID:
PMC4228129
.
Citations:
9
Fields:
Neu
Neurology
Translation:
Animals
Shyti R, Eikermann-Haerter K, van Heiningen SH, Meijer OC,
Ayata C
, Joëls M, Ferrari MD, van den Maagdenberg AM, Tolner EA. Stress hormone corticosterone enhances susceptibility to cortical spreading depression in familial hemiplegic migraine type 1 mutant mice. Exp Neurol. 2015 Jan; 263:214-20.
PMID:
25447936
.
Citations:
15
Fields:
Neu
Neurology
Translation:
Animals
Ebrahimkhani MR, Daneshmand A, Mazumder A, Allocca M, Calvo JA, Abolhassani N, Jhun I, Muthupalani S,
Ayata C
, Samson LD. Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):E4878-86.
PMID:
25349415
; PMCID:
PMC4234618
.
Citations:
29
Fields:
Sci
Science
Translation:
Animals
Cells
Mawet J,
Kurth T
,
Ayata C
. Migraine and stroke: in search of shared mechanisms. Cephalalgia. 2015 Feb; 35(2):165-81.
PMID:
25228681
.
Citations:
27
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Humans
Blasi F, Wei Y, Balkaya M, Tikka S,
Mandeville JB
, Waeber C,
Ayata C
,
Moskowitz MA
. Recognition memory impairments after subcortical white matter stroke in mice. Stroke. 2014 May; 45(5):1468-73.
PMID:
24723319
.
Citations:
15
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Animals
Lu L, Barfejani AH, Qin T, Dong Q,
Ayata C
, Waeber C. Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage. Brain Res. 2014 Mar 25; 1555:89-96.
PMID:
24502984
.
Citations:
34
Fields:
Bra
Brain
Translation:
Animals
Boltze J,
Ayata C
, Wagner DC, Plesnila N. Preclinical phase III trials in translational stroke research: call for collective design of framework and guidelines. Stroke. 2014 Feb; 45(2):357.
PMID:
24407954
; PMCID:
PMC3970114
.
Citations:
7
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Humans
Lee JH, Zheng Y, von Bornstadt D, Wei Y,
Balcioglu A
, Daneshmand A, Yalcin N, Yu E, Herisson F, Atalay YB, Kim MH, Ahn YJ, Balkaya M, Sweetnam P, Schueller O, Poyurovsky MV, Kim HH,
Lo EH
, Furie KL,
Ayata C
. Selective ROCK2 Inhibition In Focal Cerebral Ischemia. Ann Clin Transl Neurol. 2014 Jan 01; 1(1):2-14.
PMID:
24466563
.
Citations:
41
Fields:
Neu
Neurology
Shin HK,
Huang PL
,
Ayata C
. Rho-kinase inhibition improves ischemic perfusion deficit in hyperlipidemic mice. J Cereb Blood Flow Metab. 2014 Feb; 34(2):284-7.
PMID:
24192634
.
Citations:
12
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Srinivasan VJ,
Mandeville ET
, Can A, Blasi F, Climov M, Daneshmand A, Lee JH, Yu E, Radhakrishnan H,
Lo EH
, Sakadžic S, Eikermann-Haerter K,
Ayata C
. Multiparametric, longitudinal optical coherence tomography imaging reveals acute injury and chronic recovery in experimental ischemic stroke. PLoS One. 2013; 8(8):e71478.
PMID:
23940761
.
Citations:
40
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Hoffmann U, Grosse-Sundrup M, Eikermann-Haerter K, Zaremba S,
Ayata C
, Zhang B, Ma D, Isaacs L, Eikermann M. Calabadion: A new agent to reverse the effects of benzylisoquinoline and steroidal neuromuscular-blocking agents. Anesthesiology. 2013 Aug; 119(2):317-25.
PMID:
23549405
.
Citations:
28
Fields:
Ane
Anesthesiology
Translation:
Animals
Miyamoto N, Pham LD,
Hayakawa K
, Matsuzaki T, Seo JH,
Magnain C
,
Ayata C
, Kim KW, Boas D,
Lo EH
,
Arai K
. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke. 2013 Sep; 44(9):2573-8.
PMID:
23881957
.
Citations:
50
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Animals
Cells
Costa C, Tozzi A, Rainero I, Cupini LM, Calabresi P,
Ayata C
, Sarchielli P. Cortical spreading depression as a target for anti-migraine agents. J Headache Pain. 2013 Jul 23; 14:62.
PMID:
23879550
.
Citations:
43
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Humans
Ayata C
. Pearls and pitfalls in experimental models of spreading depression. Cephalalgia. 2013 Jun; 33(8):604-13.
PMID:
23671256
.
Citations:
30
Fields:
Neu
Neurology
Psy
Psychophysiology
Translation:
Humans
Animals
Ayata C
. Spreading depression and neurovascular coupling. Stroke. 2013 Jun; 44(6 Suppl 1):S87-9.
PMID:
23709742
.
Citations:
26
Fields:
Bra
Brain
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
Ayata C
, Shin HK, Dileköz E,
Atochin DN
,
Kashiwagi S
, Eikermann-Haerter K,
Huang PL
. Hyperlipidemia disrupts cerebrovascular reflexes and worsens ischemic perfusion defect. J Cereb Blood Flow Metab. 2013 Jun; 33(6):954-62.
PMID:
23486293
.
Citations:
24
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Cells
Koide M, Sukhotinsky I,
Ayata C
, Wellman GC. Subarachnoid hemorrhage, spreading depolarizations and impaired neurovascular coupling. Stroke Res Treat. 2013; 2013:819340.
PMID:
23577279
.
Citations:
21
Dapul HR, Park J, Zhang J, Lee C, DanEshmand A, Lok J,
Ayata C
, Gray T, Scalzo A, Qiu J,
Lo EH
,
Whalen MJ
. Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in mice. J Neurotrauma. 2013 Mar 01; 30(5):382-91.
PMID:
23153355
.
Citations:
7
Fields:
Neu
Neurology
Tra
Traumatology
Translation:
Animals
Lee J, Radhakrishnan H, Wu W, Daneshmand A, Climov M,
Ayata C
, Boas DA. Quantitative imaging of cerebral blood flow velocity and intracellular motility using dynamic light scattering-optical coherence tomography. J Cereb Blood Flow Metab. 2013 Jun; 33(6):819-25.
PMID:
23403378
.
Citations:
24
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Cells
Seo JH, Miyamoto N,
Hayakawa K
, Pham LD, Maki T,
Ayata C
, Kim KW,
Lo EH
,
Arai K
. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest. 2013 Feb; 123(2):782-6.
PMID:
23281396
; PMCID:
PMC3561802
.
Citations:
84
Fields:
Med
Medicine (General)
Translation:
Animals
Cells
Eikermann-Haerter K, Negro A,
Ayata C
. Spreading depression and the clinical correlates of migraine. Rev Neurosci. 2013; 24(4):353-63.
PMID:
23907418
.
Citations:
18
Fields:
Neu
Neurology
Translation:
Humans
Animals
Hoffmann U,
Ayata C
. Neurovascular coupling during spreading depolarizations. Acta Neurochir Suppl. 2013; 115:161-5.
PMID:
22890663
.
Citations:
12
Fields:
Neu
Neurosurgery
Translation:
Humans
Animals
Hoffmann U, Sukhotinsky I, Eikermann-Haerter K,
Ayata C
. Glucose modulation of spreading depression susceptibility. J Cereb Blood Flow Metab. 2013 Feb; 33(2):191-5.
PMID:
22968322
.
Citations:
27
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals
Hoffmann U, Sukhotinsky I, Atalay YB, Eikermann-Haerter K,
Ayata C
. Increased glucose availability does not restore prolonged spreading depression durations in hypotensive rats without brain injury. Exp Neurol. 2012 Dec; 238(2):130-2.
PMID:
22981452
.
Citations:
7
Fields:
Neu
Neurology
Translation:
Animals
Eikermann-Haerter K, Can A,
Ayata C
. Pharmacological targeting of spreading depression in migraine. Expert Rev Neurother. 2012 Mar; 12(3):297-306.
PMID:
22364328
.
Citations:
11
Fields:
Neu
Neurology
The
Therapeutics
Translation:
Humans
Animals
Lee JH,
Bacskai BJ
,
Ayata C
. Genetic animal models of cerebral vasculopathies. Prog Mol Biol Transl Sci. 2012; 105:25-55.
PMID:
22137428
.
Citations:
6
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Eikermann-Haerter K, Lee JH, Yuzawa I, Liu CH, Zhou Z, Shin HK, Zheng Y, Qin T,
Kurth T
, Waeber C, Ferrari MD, van den Maagdenberg AM,
Moskowitz MA
,
Ayata C
. Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations. Circulation. 2012 Jan 17; 125(2):335-45.
PMID:
22144569
; PMCID:
PMC3276214
.
Citations:
63
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Garcia-Alloza M, Gregory J, Kuchibhotla KV, Fine S, Wei Y,
Ayata C
,
Frosch MP
,
Greenberg SM
,
Bacskai BJ
. Cerebrovascular lesions induce transient ß-amyloid deposition. Brain. 2011 Dec; 134(Pt 12):3697-707.
PMID:
22120142
; PMCID:
PMC3235567
.
Citations:
85
Fields:
Bra
Brain
Neu
Neurology
Translation:
Humans
Animals
Cells
Yuzawa I, Sakadžic S, Srinivasan VJ, Shin HK, Eikermann-Haerter K, Boas DA,
Ayata C
. Cortical spreading depression impairs oxygen delivery and metabolism in mice. J Cereb Blood Flow Metab. 2012 Feb; 32(2):376-86.
PMID:
22008729
.
Citations:
28
Fields:
Bra
Brain
Met
Metabolism
Vas
Vascular Diseases
Translation:
Animals