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Cenk Ayata, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS102969 (AYATA, CENK) Jul 15, 2017 - Apr 30, 2022
    NIH/NINDS
    Non-invasive vagus nerve stimulation targeting cortical spreading depression in migrane prophylaxis
    Role: Principal Investigator
  2. R01NS061505 (AYATA, CENK) Jan 15, 2008 - Dec 31, 2013
    NIH/NINDS
    Neural &Vascular Dysfunction As Mechanisms of Injury in Genetic Migraine Models
    Role: Principal Investigator
  3. P01NS055104 (LO, ENG H.) Jul 1, 2007 - Apr 30, 2019
    NIH/NINDS
    Remodeling and recovery in the neurovascular unit
    Role: Co-Principal Investigator
  4. P50NS051343 (GREENBERG, STEVEN M) Apr 1, 2005 - Jun 30, 2014
    NIH/NINDS
    Specialized Programs of Translational Research in Acute Stroke at the Partners
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Chung DY, Sugimoto K, Fischer P, Böhm M, Takizawa T, Sadeghian H, Morais A, Harriott A, Oka F, Qin T, Henninger N, Yaseen MA, Sakadžic S, Ayata C. Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice. J Neurosci Methods. 2018 Sep 04. PMID: 30194041.
    View in: PubMed
  2. Bouley J, Chung DY, Ayata C, Brown RH, Henninger N. Cortical Spreading Depression Denotes Concussion Injury. J Neurotrauma. 2018 Aug 24. PMID: 29999455.
    View in: PubMed
  3. Sadeghian H, Lacoste B, Qin T, Toussay X, Rosa R, Oka F, Chung DY, Takizawa T, Gu C, Ayata C. Spreading depolarizations trigger caveolin-1-dependent endothelial transcytosis. Ann Neurol. 2018 Jul 16. PMID: 30014540.
    View in: PubMed
  4. Ayata C. Monitoring anoxic depolarization at the bedside: A step closer to the 24th century. J Cereb Blood Flow Metab. 2018 Jul; 38(7):1123-1124. PMID: 29961421.
    View in: PubMed
  5. Rosenthal ES, Biswal S, Zafar SF, O'Connor KL, Bechek S, Shenoy AV, Boyle EJ, Shafi MM, Gilmore EJ, Foreman BP, Gaspard N, Leslie-Mazwi TM, Rosand J, Hoch DB, Ayata C, Cash SS, Cole AJ, Patel AB, Westover MB. Continuous electroencephalography predicts delayed cerebral ischemia after subarachnoid hemorrhage: A prospective study of diagnostic accuracy. Ann Neurol. 2018 May; 83(5):958-969. PMID: 29659050.
    View in: PubMed
  6. Akhter M, Qin T, Fischer P, Sadeghian H, Kim HH, Whalen MJ, Goldstein JN, Ayata C. Rho-kinase inhibitors do not expand hematoma volume in acute experimental intracerebral hemorrhage. Ann Clin Transl Neurol. 2018 Jun; 5(6):769-776. PMID: 29928660.
    View in: PubMed
  7. Lan J, Esposito E, Ayata C, Singhal AB, Lo EH, Ji X. Different Effects of Normobaric Oxygen in Normotensive Versus Hypertensive Rats After Focal Cerebral Ischemia. Stroke. 2018 Jun; 49(6):1534-1537. PMID: 29712880.
    View in: PubMed
  8. Xie H, Yu K, Zhou N, Shen X, Tian S, Zhang B, Wang Y, Wu J, Liu G, Jiang C, Hu R, Ayata C, Wu Y. Enriched Environment Elicits Proangiogenic Mechanisms After Focal Cerebral Ischemia. Transl Stroke Res. 2018 Apr 26. PMID: 29700717.
    View in: PubMed
  9. Yalcin N, Chen SP, Yu ES, Liu TT, Yen JC, Atalay YB, Qin T, Celik F, van den Maagdenberg AM, Moskowitz MA, Ayata C, Eikermann-Haerter K. Caffeine does not affect susceptibility to cortical spreading depolarization in mice. J Cereb Blood Flow Metab. 2018 04 13; 271678X18768955. PMID: 29651899.
    View in: PubMed
  10. Bix GJ, Fraser JF, Mack WJ, Carmichael ST, Perez-Pinzon M, Offner H, Sansing L, Bosetti F, Ayata C, Pennypacker KR. Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical. Transl Stroke Res. 2018 Jun; 9(3):258-266. PMID: 29633156.
    View in: PubMed
  11. Iljazi A, Ayata C, Ashina M, Hougaard A. The Role of Endothelin in the Pathophysiology of Migraine-a Systematic Review. Curr Pain Headache Rep. 2018 Mar 19; 22(4):27. PMID: 29557064.
    View in: PubMed
  12. Waddington DEJ, Sarracanie M, Salameh N, Herisson F, Ayata C, Rosen MS. An Overhauser-enhanced-MRI platform for dynamic free radical imaging in vivo. NMR Biomed. 2018 May; 31(5):e3896. PMID: 29493032.
    View in: PubMed
  13. Kura S, Xie H, Fu B, Ayata C, Boas DA, Sakadžic S. Intrinsic optical signal imaging of the blood volume changes is sufficient for mapping the resting state functional connectivity in the rodent cortex. J Neural Eng. 2018 Jun; 15(3):035003. PMID: 29451130.
    View in: PubMed
  14. Chung DY, Sadeghian H, Qin T, Lule S, Lee H, Karakaya F, Goins S, Oka F, Yaseen MA, Houben T, Tolner EA, van den Maagdenberg AMJM, Whalen MJ, Sakadžic S, Ayata C. Determinants of Optogenetic Cortical Spreading Depolarizations. Cereb Cortex. 2018 Feb 07. PMID: 29425263.
    View in: PubMed
  15. Herisson F, Zhou I, Mawet J, Du E, Barfejani AH, Qin T, Cipolla MJ, Sun PZ, Rost NS, Ayata C. Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet. J Cereb Blood Flow Metab. 2018 01 19; 271678X17752795. PMID: 29350576.
    View in: PubMed
  16. Chen SP, Ayata C. Novel Therapeutic Targets Against Spreading Depression. Headache. 2017 Oct; 57(9):1340-1358. PMID: 28842982.
    View in: PubMed
  17. Bosetti F, Koenig JI, Ayata C, Back SA, Becker K, Broderick JP, Carmichael ST, Cho S, Cipolla MJ, Corbett D, Corriveau RA, Cramer SC, Ferguson AR, Finklestein SP, Ford BD, Furie KL, Hemmen TM, Iadecola C, Jakeman LB, Janis S, Jauch EC, Johnston KC, Kochanek PM, Kohn H, Lo EH, Lyden PD, Mallard C, McCullough LD, McGavern LM, Meschia JF, Moy CS, Perez-Pinzon MA, Ramadan I, Savitz SI, Schwamm LH, Steinberg GK, Stenzel-Poore MP, Tymianski M, Warach S, Wechsler LR, Zhang JH, Koroshetz W. Translational Stroke Research: Vision and Opportunities. Stroke. 2017 09; 48(9):2632-2637. PMID: 28751554.
    View in: PubMed
  18. Charidimou A, Boulouis G, Gurol ME, Ayata C, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM. Emerging concepts in sporadic cerebral amyloid angiopathy. Brain. 2017 Jul 01; 140(7):1829-1850. PMID: 28334869.
    View in: PubMed
  19. Chen SP, Qin T, Seidel JL, Zheng Y, Eikermann M, Ferrari MD, van den Maagdenberg AMJM, Moskowitz MA, Ayata C, Eikermann-Haerter K. Inhibition of the P2X7-PANX1 complex suppresses spreading depolarization and neuroinflammation. Brain. 2017 Jun 01; 140(6):1643-1656. PMID: 28430869.
    View in: PubMed
  20. Khan S, Amin FM, Holtmannspötter M, Hansen K, Florescu AM, Fakhril-Din Z, Petersen JF, Ghanizada H, Ayata C, Gaist D, Ashina M. Endovascular thrombectomy and post-procedural headache. J Headache Pain. 2017 Dec; 18(1):10. PMID: 28130625.
    View in: PubMed
  21. Sun PZ, Ayata C, Lo EH. Fleeting footprints: finding MRI biomarkers of transient ischaemic attack. Brain. 2017 01; 140(1):8-10. PMID: 28031217.
    View in: PubMed
  22. Kim YS, Yoo A, Son JW, Kim HY, Lee YJ, Hwang S, Lee KY, Lee YJ, Ayata C, Kim HH, Koh SH. Early Activation of Phosphatidylinositol 3-Kinase after Ischemic Stroke Reduces Infarct Volume and Improves Long-Term Behavior. Mol Neurobiol. 2017 09; 54(7):5375-5384. PMID: 27590139.
    View in: PubMed
  23. Mandeville ET, Ayata C, Zheng Y, Mandeville JB. Translational MR Neuroimaging of Stroke and Recovery. Transl Stroke Res. 2017 02; 8(1):22-32. PMID: 27578048.
    View in: PubMed
  24. Boltze J, Ayata C. Challenges and Controversies in Translational Stroke Research - an Introduction. Transl Stroke Res. 2016 10; 7(5):355-7. PMID: 27581304.
    View in: PubMed
  25. Ayata C. Migraine: Treasure hunt in a minefield - exploring migraine with GWAS. Nat Rev Neurol. 2016 09; 12(9):496-8. PMID: 27539559.
    View in: PubMed
  26. Hoffmann U, Sheng H, Ayata C, Warner DS. Anesthesia in Experimental Stroke Research. Transl Stroke Res. 2016 10; 7(5):358-67. PMID: 27534542; PMCID: PMC5016251 [Available on 10/01/17].
  27. Chen SP, Ayata C. Spreading Depression in Primary and Secondary Headache Disorders. Curr Pain Headache Rep. 2016 Jul; 20(7):44. PMID: 27215627.
    View in: PubMed
  28. Boltze J, Wagner DC, Henninger N, Plesnila N, Ayata C. Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines. Transl Stroke Res. 2016 08; 7(4):241-7. PMID: 27297402; PMCID: PMC4927600.
  29. Chung DY, Oka F, Ayata C. Spreading Depolarizations: A Therapeutic Target Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. J Clin Neurophysiol. 2016 Jun; 33(3):196-202. PMID: 27258442; PMCID: PMC4894342 [Available on 06/01/17].
  30. Singhal AB, Maas MB, Goldstein JN, Mills BB, Chen DW, Ayata C, Kacmarek RM, Topcuoglu MA. High-flow oxygen therapy for treatment of acute migraine: A randomized crossover trial. Cephalalgia. 2017 Jul; 37(8):730-736. PMID: 27206964.
    View in: PubMed
  31. Chen SP, Ay I, de Morais AL, Qin T, Zheng Y, Sadeghian H, Oka F, Simon B, Eikermann-Haerter K, Ayata C. Vagus nerve stimulation inhibits cortical spreading depression. Pain. 2016 Apr; 157(4):797-805. PMID: 26645547; PMCID: PMC4943574 [Available on 04/01/17].
  32. Dreier JP, Fabricius M, Ayata C, Sakowitz OW, William Shuttleworth C, Dohmen C, Graf R, Vajkoczy P, Helbok R, Suzuki M, Schiefecker AJ, Major S, Winkler MK, Kang EJ, Milakara D, Oliveira-Ferreira AI, Reiffurth C, Revankar GS, Sugimoto K, Dengler NF, Hecht N, Foreman B, Feyen B, Kondziella D, Friberg CK, Piilgaard H, Rosenthal ES, Westover MB, Maslarova A, Santos E, Hertle D, Sánchez-Porras R, Jewell SL, Balança B, Platz J, Hinzman JM, Lückl J, Schoknecht K, Schöll M, Drenckhahn C, Feuerstein D, Eriksen N, Horst V, Bretz JS, Jahnke P, Scheel M, Bohner G, Rostrup E, Pakkenberg B, Heinemann U, Claassen J, Carlson AP, Kowoll CM, Lublinsky S, Chassidim Y, Shelef I, Friedman A, Brinker G, Reiner M, Kirov SA, Andrew RD, Farkas E, Güresir E, Vatter H, Chung LS, Brennan KC, Lieutaud T, Marinesco S, Maas AI, Sahuquillo J, Dahlem MA, Richter F, Herreras O, Boutelle MG, Okonkwo DO, Bullock MR, Witte OW, Martus P, van den Maagdenberg AM, Ferrari MD, Dijkhuizen RM, Shutter LA, Andaluz N, Schulte AP, MacVicar B, Watanabe T, Woitzik J, Lauritzen M, Strong AJ, Hartings JA. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group. J Cereb Blood Flow Metab. 2017 May; 37(5):1595-1625. PMID: 27317657.
    View in: PubMed
  33. Hartings JA, Shuttleworth CW, Kirov SA, Ayata C, Hinzman JM, Foreman B, Andrew RD, Boutelle MG, Brennan KC, Carlson AP, Dahlem MA, Drenckhahn C, Dohmen C, Fabricius M, Farkas E, Feuerstein D, Graf R, Helbok R, Lauritzen M, Major S, Oliveira-Ferreira AI, Richter F, Rosenthal ES, Sakowitz OW, Sánchez-Porras R, Santos E, Schöll M, Strong AJ, Urbach A, Westover MB, Winkler MK, Witte OW, Woitzik J, Dreier JP. The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão's legacy. J Cereb Blood Flow Metab. 2017 May; 37(5):1571-1594. PMID: 27328690.
    View in: PubMed
  34. Oka F, Hoffmann U, Lee JH, Shin HK, Chung DY, Yuzawa I, Chen SP, Atalay YB, Nozari A, Hopson KP, Qin T, Ayata C. Requisite ischemia for spreading depolarization occurrence after subarachnoid hemorrhage in rodents. J Cereb Blood Flow Metab. 2017 May; 37(5):1829-1840. PMID: 27432225.
    View in: PubMed
  35. Haerter F, Simons JC, Foerster U, Moreno Duarte I, Diaz-Gil D, Ganapati S, Eikermann-Haerter K, Ayata C, Zhang B, Blobner M, Isaacs L, Eikermann M. Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents. Anesthesiology. 2015 Dec; 123(6):1337-49. PMID: 26418697.
    View in: PubMed
  36. Mawet J, Eikermann-Haerter K, Park KY, Helenius J, Daneshmand A, Pearlman L, Avery R, Negro A, Velioglu M, Arsava EM, Ay H, Ayata C. Sensitivity to acute cerebral ischemic injury in migraineurs: A retrospective case-control study. Neurology. 2015 Dec 01; 85(22):1945-9. PMID: 26537055.
    View in: PubMed
  37. Seidel JL, Escartin C, Ayata C, Bonvento G, Shuttleworth CW. Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury? Glia. 2016 Jan; 64(1):5-20. PMID: 26301517; PMCID: PMC4715804 [Available on 01/01/17].
  38. Srinivasan VJ, Yu E, Radhakrishnan H, Can A, Climov M, Leahy C, Ayata C, Eikermann-Haerter K. Micro-heterogeneity of flow in a mouse model of chronic cerebral hypoperfusion revealed by longitudinal Doppler optical coherence tomography and angiography. J Cereb Blood Flow Metab. 2015 Oct; 35(10):1552-60. PMID: 26243708; PMCID: PMC4640323 [Available on 10/01/16].
  39. Buckley EM, Miller BF, Golinski JM, Sadeghian H, McAllister LM, Vangel M, Ayata C, Meehan WP, Franceschini MA, Whalen MJ. Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice. J Cereb Blood Flow Metab. 2015 Dec; 35(12):1995-2000. PMID: 26154866; PMCID: PMC4671120 [Available on 12/01/16].
  40. Eikermann-Haerter K, Arbel-Ornath M, Yalcin N, Yu ES, Kuchibhotla KV, Yuzawa I, Hudry E, Willard CR, Climov M, Keles F, Belcher AM, Sengul B, Negro A, Rosen IA, Arreguin A, Ferrari MD, van den Maagdenberg AM, Bacskai BJ, Ayata C. Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. Ann Neurol. 2015 Aug; 78(2):193-210. PMID: 26032020; PMCID: PMC4515184.
  41. Ayata C, Lauritzen M. Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiol Rev. 2015 Jul; 95(3):953-93. PMID: 26133935; PMCID: PMC4491545.
  42. Wilks MQ, Normandin MD, Yuan H, Cho H, Guo Y, Herisson F, Ayata C, Wooten DW, El Fakhri G, Josephson L. Imaging PEG-like nanoprobes in tumor, transient ischemia, and inflammatory disease models. Bioconjug Chem. 2015 Jun 17; 26(6):1061-9. PMID: 25971846.
    View in: PubMed
  43. Sakadžic S, Lee J, Boas DA, Ayata C. High-resolution in vivo optical imaging of stroke injury and repair. Brain Res. 2015 Oct 14; 1623:174-92. PMID: 25960347; PMCID: PMC4569527 [Available on 10/14/16].
  44. Blasi F, Herisson F, Wang S, Mao J, Ayata C. Late-onset thermal hypersensitivity after focal ischemic thalamic infarcts as a model for central post-stroke pain in rats. J Cereb Blood Flow Metab. 2015 Jul; 35(7):1100-3. PMID: 25899295; PMCID: PMC4640279.
  45. von Bornstädt D, Houben T, Seidel JL, Zheng Y, Dilekoz E, Qin T, Sandow N, Kura S, Eikermann-Haerter K, Endres M, Boas DA, Moskowitz MA, Lo EH, Dreier JP, Woitzik J, Sakadžic S, Ayata C. Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations. Neuron. 2015 Mar 04; 85(5):1117-31. PMID: 25741731; PMCID: PMC4351476.
  46. Chaparro RE, Izutsu M, Sasaki T, Sheng H, Zheng Y, Sadeghian H, Qin T, von Bornstadt D, Herisson F, Duan B, Li JS, Jiang K, Pearlstein M, Pearlstein RD, Smith DE, Goldberg ID, Ayata C, Warner DS. Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice. J Cereb Blood Flow Metab. 2015 Jun; 35(6):1044-53. PMID: 25712497; PMCID: PMC4640251.
  47. Dilekoz E, Houben T, Eikermann-Haerter K, Balkaya M, Lenselink AM, Whalen MJ, Spijker S, Ferrari MD, van den Maagdenberg AM, Ayata C. Migraine mutations impair hippocampal learning despite enhanced long-term potentiation. J Neurosci. 2015 Feb 25; 35(8):3397-402. PMID: 25716839; PMCID: PMC4339352.
  48. Blasi F, Whalen MJ, Ayata C. Lasting pure-motor deficits after focal posterior internal capsule white-matter infarcts in rats. J Cereb Blood Flow Metab. 2015 Jun; 35(6):977-84. PMID: 25649992; PMCID: PMC4640262.
  49. Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf NA, Wang H, Silverman RB, Ayata C, Maxwell MM, Steegborn C, Schwarzschild MA, Outeiro TF, Kazantsev AG. The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. PLoS One. 2015; 10(1):e0116919. PMID: 25608039; PMCID: PMC4301865.
  50. Ferrari MD, Klever RR, Terwindt GM, Ayata C, van den Maagdenberg AM. Migraine pathophysiology: lessons from mouse models and human genetics. Lancet Neurol. 2015 Jan; 14(1):65-80. PMID: 25496898.
    View in: PubMed
  51. Diaz-Gil D, Mueller N, Moreno-Duarte I, Lin H, Ayata C, Cusin C, Cotten JF, Eikermann M. Etomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in Rats. Pharmaceuticals (Basel). 2014 Dec 29; 8(1):21-37. PMID: 25551398; PMCID: PMC4381199.
  52. Sakadžic S, Mandeville ET, Gagnon L, Musacchia JJ, Yaseen MA, Yucel MA, Lefebvre J, Lesage F, Dale AM, Eikermann-Haerter K, Ayata C, Srinivasan VJ, Lo EH, Devor A, Boas DA. Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue. Nat Commun. 2014 Dec 08; 5:5734. PMID: 25483924; PMCID: PMC4260810.
  53. Eikermann-Haerter K, Lee JH, Yalcin N, Yu ES, Daneshmand A, Wei Y, Zheng Y, Can A, Sengul B, Ferrari MD, van den Maagdenberg AM, Ayata C. Migraine prophylaxis, ischemic depolarizations, and stroke outcomes in mice. Stroke. 2015 Jan; 46(1):229-36. PMID: 25424478; PMCID: PMC4276468.
  54. Shin HK, Oka F, Kim JH, Atochin D, Huang PL, Ayata C. Endothelial dysfunction abrogates the efficacy of normobaric hyperoxia in stroke. J Neurosci. 2014 Nov 12; 34(46):15200-7. PMID: 25392489; PMCID: PMC4228129.
  55. Shyti R, Eikermann-Haerter K, van Heiningen SH, Meijer OC, Ayata C, Joëls M, Ferrari MD, van den Maagdenberg AM, Tolner EA. Stress hormone corticosterone enhances susceptibility to cortical spreading depression in familial hemiplegic migraine type 1 mutant mice. Exp Neurol. 2015 Jan; 263:214-20. PMID: 25447936.
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  56. Ebrahimkhani MR, Daneshmand A, Mazumder A, Allocca M, Calvo JA, Abolhassani N, Jhun I, Muthupalani S, Ayata C, Samson LD. Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):E4878-86. PMID: 25349415; PMCID: PMC4234618.
  57. Mawet J, Kurth T, Ayata C. Migraine and stroke: in search of shared mechanisms. Cephalalgia. 2015 Feb; 35(2):165-81. PMID: 25228681.
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  58. Blasi F, Wei Y, Balkaya M, Tikka S, Mandeville JB, Waeber C, Ayata C, Moskowitz MA. Recognition memory impairments after subcortical white matter stroke in mice. Stroke. 2014 May; 45(5):1468-73. PMID: 24723319.
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  59. Lu L, Barfejani AH, Qin T, Dong Q, Ayata C, Waeber C. Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage. Brain Res. 2014 Mar 25; 1555:89-96. PMID: 24502984; PMCID: PMC3994537.
  60. Boltze J, Ayata C, Wagner DC, Plesnila N. Preclinical phase III trials in translational stroke research: call for collective design of framework and guidelines. Stroke. 2014 Feb; 45(2):357. PMID: 24407954; PMCID: PMC3970114.
  61. Lee JH, Zheng Y, von Bornstadt D, Wei Y, Balcioglu A, Daneshmand A, Yalcin N, Yu E, Herisson F, Atalay YB, Kim MH, Ahn YJ, Balkaya M, Sweetnam P, Schueller O, Poyurovsky MV, Kim HH, Lo EH, Furie KL, Ayata C. Selective ROCK2 Inhibition In Focal Cerebral Ischemia. Ann Clin Transl Neurol. 2014 Jan 01; 1(1):2-14. PMID: 24466563.
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  62. Shin HK, Huang PL, Ayata C. Rho-kinase inhibition improves ischemic perfusion deficit in hyperlipidemic mice. J Cereb Blood Flow Metab. 2014 Feb; 34(2):284-7. PMID: 24192634; PMCID: PMC3915205.
  63. Srinivasan VJ, Mandeville ET, Can A, Blasi F, Climov M, Daneshmand A, Lee JH, Yu E, Radhakrishnan H, Lo EH, Sakadžic S, Eikermann-Haerter K, Ayata C. Multiparametric, longitudinal optical coherence tomography imaging reveals acute injury and chronic recovery in experimental ischemic stroke. PLoS One. 2013; 8(8):e71478. PMID: 23940761; PMCID: PMC3737090.
  64. Hoffmann U, Grosse-Sundrup M, Eikermann-Haerter K, Zaremba S, Ayata C, Zhang B, Ma D, Isaacs L, Eikermann M. Calabadion: A new agent to reverse the effects of benzylisoquinoline and steroidal neuromuscular-blocking agents. Anesthesiology. 2013 Aug; 119(2):317-25. PMID: 23549405.
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  65. Miyamoto N, Pham LD, Hayakawa K, Matsuzaki T, Seo JH, Magnain C, Ayata C, Kim KW, Boas D, Lo EH, Arai K. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke. 2013 Sep; 44(9):2573-8. PMID: 23881957; PMCID: PMC3818687.
  66. Costa C, Tozzi A, Rainero I, Cupini LM, Calabresi P, Ayata C, Sarchielli P. Cortical spreading depression as a target for anti-migraine agents. J Headache Pain. 2013 Jul 23; 14:62. PMID: 23879550; PMCID: PMC3728002.
  67. Ayata C. Spreading depression and neurovascular coupling. Stroke. 2013 Jun; 44(6 Suppl 1):S87-9. PMID: 23709742.
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  68. Ayata C. Pearls and pitfalls in experimental models of spreading depression. Cephalalgia. 2013 Jun; 33(8):604-13. PMID: 23671256.
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  69. Ayata C, Shin HK, Dileköz E, Atochin DN, Kashiwagi S, Eikermann-Haerter K, Huang PL. Hyperlipidemia disrupts cerebrovascular reflexes and worsens ischemic perfusion defect. J Cereb Blood Flow Metab. 2013 Jun; 33(6):954-62. PMID: 23486293; PMCID: PMC3677117.
  70. Koide M, Sukhotinsky I, Ayata C, Wellman GC. Subarachnoid hemorrhage, spreading depolarizations and impaired neurovascular coupling. Stroke Res Treat. 2013; 2013:819340. PMID: 23577279; PMCID: PMC3610342.
  71. Dapul HR, Park J, Zhang J, Lee C, DanEshmand A, Lok J, Ayata C, Gray T, Scalzo A, Qiu J, Lo EH, Whalen MJ. Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in mice. J Neurotrauma. 2013 Mar 01; 30(5):382-91. PMID: 23153355; PMCID: PMC3593692.
  72. Lee J, Radhakrishnan H, Wu W, Daneshmand A, Climov M, Ayata C, Boas DA. Quantitative imaging of cerebral blood flow velocity and intracellular motility using dynamic light scattering-optical coherence tomography. J Cereb Blood Flow Metab. 2013 Jun; 33(6):819-25. PMID: 23403378; PMCID: PMC3677104.
  73. Seo JH, Miyamoto N, Hayakawa K, Pham LD, Maki T, Ayata C, Kim KW, Lo EH, Arai K. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest. 2013 Feb; 123(2):782-6. PMID: 23281396; PMCID: PMC3561802.
  74. Eikermann-Haerter K, Negro A, Ayata C. Spreading depression and the clinical correlates of migraine. Rev Neurosci. 2013; 24(4):353-63. PMID: 23907418.
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  75. Hoffmann U, Ayata C. Neurovascular coupling during spreading depolarizations. Acta Neurochir Suppl. 2013; 115:161-5. PMID: 22890663.
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  76. Hoffmann U, Sukhotinsky I, Eikermann-Haerter K, Ayata C. Glucose modulation of spreading depression susceptibility. J Cereb Blood Flow Metab. 2013 Feb; 33(2):191-5. PMID: 22968322; PMCID: PMC3564186.
  77. Hoffmann U, Sukhotinsky I, Atalay YB, Eikermann-Haerter K, Ayata C. Increased glucose availability does not restore prolonged spreading depression durations in hypotensive rats without brain injury. Exp Neurol. 2012 Dec; 238(2):130-2. PMID: 22981452; PMCID: PMC3498578.
  78. Eikermann-Haerter K, Can A, Ayata C. Pharmacological targeting of spreading depression in migraine. Expert Rev Neurother. 2012 Mar; 12(3):297-306. PMID: 22364328; PMCID: PMC3321647.
  79. Lee JH, Bacskai BJ, Ayata C. Genetic animal models of cerebral vasculopathies. Prog Mol Biol Transl Sci. 2012; 105:25-55. PMID: 22137428; PMCID: PMC3910291.
  80. Eikermann-Haerter K, Lee JH, Yuzawa I, Liu CH, Zhou Z, Shin HK, Zheng Y, Qin T, Kurth T, Waeber C, Ferrari MD, van den Maagdenberg AM, Moskowitz MA, Ayata C. Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations. Circulation. 2012 Jan 17; 125(2):335-45. PMID: 22144569; PMCID: PMC3276214.
  81. Garcia-Alloza M, Gregory J, Kuchibhotla KV, Fine S, Wei Y, Ayata C, Frosch MP, Greenberg SM, Bacskai BJ. Cerebrovascular lesions induce transient ß-amyloid deposition. Brain. 2011 Dec; 134(Pt 12):3697-707. PMID: 22120142; PMCID: PMC3235567.
  82. Yuzawa I, Sakadžic S, Srinivasan VJ, Shin HK, Eikermann-Haerter K, Boas DA, Ayata C. Cortical spreading depression impairs oxygen delivery and metabolism in mice. J Cereb Blood Flow Metab. 2012 Feb; 32(2):376-86. PMID: 22008729; PMCID: PMC3272607.
  83. Sukhotinsky I, Dilekoz E, Wang Y, Qin T, Eikermann-Haerter K, Waeber C, Ayata C. Chronic daily cortical spreading depressions suppress spreading depression susceptibility. Cephalalgia. 2011 Dec; 31(16):1601-8. PMID: 22013142.
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  84. Baraghis E, Devor A, Fang Q, Srinivasan VJ, Wu W, Lesage F, Ayata C, Kasischke KA, Boas DA, Sakadzic S. Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response. J Biomed Opt. 2011 Oct; 16(10):106003. PMID: 22029350; PMCID: PMC3206923.
  85. Arboleda-Velasquez JF, Manent J, Lee JH, Tikka S, Ospina C, Vanderburg CR, Frosch MP, Rodríguez-Falcón M, Villen J, Gygi S, Lopera F, Kalimo H, Moskowitz MA, Ayata C, Louvi A, Artavanis-Tsakonas S. Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):E128-35. PMID: 21555590; PMCID: PMC3102344.
  86. Vieira RP, Müller T, Grimm M, von Gernler V, Vetter B, Dürk T, Cicko S, Ayata CK, Sorichter S, Robaye B, Zeiser R, Ferrari D, Kirschbaum A, Zissel G, Virchow JC, Boeynaems JM, Idzko M. Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation. Am J Respir Crit Care Med. 2011 Jul 15; 184(2):215-23. PMID: 21512170.
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  87. Hoffmann U, Lee JH, Qin T, Eikermann-Haerter K, Ayata C. Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations. J Cereb Blood Flow Metab. 2011 Jul; 31(7):1578-82. PMID: 21505480; PMCID: PMC3137475.
  88. Eikermann-Haerter K, Yuzawa I, Qin T, Wang Y, Baek K, Kim YR, Hoffmann U, Dilekoz E, Waeber C, Ferrari MD, van den Maagdenberg AM, Moskowitz MA, Ayata C. Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice. J Neurosci. 2011 Apr 13; 31(15):5755-63. PMID: 21490217; PMCID: PMC3135337.
  89. Srinivasan VJ, Atochin DN, Radhakrishnan H, Jiang JY, Ruvinskaya S, Wu W, Barry S, Cable AE, Ayata C, Huang PL, Boas DA. Optical coherence tomography for the quantitative study of cerebrovascular physiology. J Cereb Blood Flow Metab. 2011 Jun; 31(6):1339-45. PMID: 21364599; PMCID: PMC3130321.
  90. Eikermann-Haerter K, Yuzawa I, Dilekoz E, Joutel A, Moskowitz MA, Ayata C. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome mutations increase susceptibility to spreading depression. Ann Neurol. 2011 Feb; 69(2):413-8. PMID: 21387384; PMCID: PMC3058390.
  91. Hoffmann U, Dileköz E, Kudo C, Ayata C. Oxcarbazepine does not suppress cortical spreading depression. Cephalalgia. 2011 Apr; 31(5):537-42. PMID: 21059627.
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  92. Ayata C. CADASIL: experimental insights from animal models. Stroke. 2010 Oct; 41(10 Suppl):S129-34. PMID: 20876488; PMCID: PMC2953736.
  93. Atochin DN, Yuzawa I, Li Q, Rauwerdink KM, Malhotra R, Chang J, Brouckaert P, Ayata C, Moskowitz MA, Bloch KD, Huang PL, Buys ES. Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury. Stroke. 2010 Aug; 41(8):1815-9. PMID: 20595671; PMCID: PMC3047459.
  94. Hoffmann U, Dileköz E, Kudo C, Ayata C. Gabapentin suppresses cortical spreading depression susceptibility. J Cereb Blood Flow Metab. 2010 Sep; 30(9):1588-92. PMID: 20588320; PMCID: PMC2949257.
  95. Eikermann-Haerter K, Ayata C. Cortical spreading depression and migraine. Curr Neurol Neurosci Rep. 2010 May; 10(3):167-73. PMID: 20425031.
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  96. Ayata C. Cortical spreading depression triggers migraine attack: pro. Headache. 2010 Apr; 50(4):725-30. PMID: 20456160.
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  97. Gohil VM, Sheth SA, Nilsson R, Wojtovich AP, Lee JH, Perocchi F, Chen W, Clish CB, Ayata C, Brookes PS, Mootha VK. Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nat Biotechnol. 2010 Mar; 28(3):249-55. PMID: 20160716; PMCID: PMC3135002.
  98. Nozari A, Dilekoz E, Sukhotinsky I, Stein T, Eikermann-Haerter K, Liu C, Wang Y, Frosch MP, Waeber C, Ayata C, Moskowitz MA. Microemboli may link spreading depression, migraine aura, and patent foramen ovale. Ann Neurol. 2010 Feb; 67(2):221-9. PMID: 20225282; PMCID: PMC2921919.
  99. Sukhotinsky I, Yaseen MA, Sakadzic S, Ruvinskaya S, Sims JR, Boas DA, Moskowitz MA, Ayata C. Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1168-77. PMID: 20087371; PMCID: PMC2921789.
  100. Jin G, Sun PZ, Singhal AB, Ayata C, Lo EH. First-order mathematical modeling of brain swelling in focal cerebral ischemia. Transl Stroke Res. 2010 Mar; 1(1):65-70. PMID: 24323451.
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  101. Ayata C. Spreading depression: from serendipity to targeted therapy in migraine prophylaxis. Cephalalgia. 2009 Oct; 29(10):1095-114. PMID: 19735536.
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  102. Eikermann-Haerter K, Baum MJ, Ferrari MD, van den Maagdenberg AM, Moskowitz MA, Ayata C. Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice. Ann Neurol. 2009 Oct; 66(4):564-8. PMID: 19847904; PMCID: PMC2783310.
  103. Sakadzic S, Yuan S, Dilekoz E, Ruvinskaya S, Vinogradov SA, Ayata C, Boas DA. Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression. Appl Opt. 2009 Apr 01; 48(10):D169-77. PMID: 19340106; PMCID: PMC2692697.
  104. Eikermann-Haerter K, Dileköz E, Kudo C, Savitz SI, Waeber C, Baum MJ, Ferrari MD, van den Maagdenberg AM, Moskowitz MA, Ayata C. Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. J Clin Invest. 2009 Jan; 119(1):99-109. PMID: 19104150.
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  105. Shin HK, Salomone S, Ayata C. Targeting cerebrovascular Rho-kinase in stroke. Expert Opin Ther Targets. 2008 Dec; 12(12):1547-64. PMID: 19007322.
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  106. Chou SH, Smith EE, Badjatia N, Nogueira RG, Sims JR, Ogilvy CS, Rordorf GA, Ayata C. A randomized, double-blind, placebo-controlled pilot study of simvastatin in aneurysmal subarachnoid hemorrhage. Stroke. 2008 Oct; 39(10):2891-3. PMID: 18658043.
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  107. Jones PB, Shin HK, Boas DA, Hyman BT, Moskowitz MA, Ayata C, Dunn AK. Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia. J Biomed Opt. 2008 Jul-Aug; 13(4):044007. PMID: 19021335; PMCID: PMC2790046.
  108. Berzi A, Ayata CK, Cavalcante P, Falcone C, Candiago E, Motta T, Bernasconi P, Hohlfeld R, Mantegazza R, Meinl E, Farina C. BDNF and its receptors in human myasthenic thymus: implications for cell fate in thymic pathology. J Neuroimmunol. 2008 Jul 15; 197(2):128-39. PMID: 18555538.
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  109. Sukhotinsky I, Dilekoz E, Moskowitz MA, Ayata C. Hypoxia and hypotension transform the blood flow response to cortical spreading depression from hyperemia into hypoperfusion in the rat. J Cereb Blood Flow Metab. 2008 Jul; 28(7):1369-76. PMID: 18446167.
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  110. Kudo C, Nozari A, Moskowitz MA, Ayata C. The impact of anesthetics and hyperoxia on cortical spreading depression. Exp Neurol. 2008 Jul; 212(1):201-6. PMID: 18501348; PMCID: PMC2459317.
  111. Arboleda-Velasquez JF, Zhou Z, Shin HK, Louvi A, Kim HH, Savitz SI, Liao JK, Salomone S, Ayata C, Moskowitz MA, Artavanis-Tsakonas S. Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4856-61. PMID: 18347334; PMCID: PMC2290794.
  112. Shin HK, Nishimura M, Jones PB, Ay H, Boas DA, Moskowitz MA, Ayata C. Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia. Stroke. 2008 May; 39(5):1548-55. PMID: 18340095; PMCID: PMC3023416.
  113. Lee SR, Lok J, Rosell A, Kim HY, Murata Y, Atochin D, Huang PL, Wang X, Ayata C, Moskowitz MA, Lo EH. Reduction of hippocampal cell death and proteolytic responses in tissue plasminogen activator knockout mice after transient global cerebral ischemia. Neuroscience. 2007 Nov 30; 150(1):50-7. PMID: 17936515; PMCID: PMC3814181.
  114. Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007 Nov; 38(11):2979-84. PMID: 17901381.
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  115. Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain. 2007 Sep; 130(Pt 9):2310-9. PMID: 17638859.
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  116. Atochin DN, Wang A, Liu VW, Critchlow JD, Dantas AP, Looft-Wilson R, Murata T, Salomone S, Shin HK, Ayata C, Moskowitz MA, Michel T, Sessa WC, Huang PL. The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest. 2007 Jul; 117(7):1961-7. PMID: 17557122; PMCID: PMC1884686.
  117. Shin HK, Dunn AK, Jones PB, Boas DA, Lo EH, Moskowitz MA, Ayata C. Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia. Brain. 2007 Jun; 130(Pt 6):1631-42. PMID: 17468117; PMCID: PMC3023418.
  118. Hwa Kyoung Shin, Sean Savitz, Christian Waeber, Michael A. Moskowitz, Cenk Ayata. Distal middle cerebral artery occlusion model for real time optical monitoring of cerebral blood flow and metabolism. BRAIN'07. 2007.
  119. Katharina Eikermann-Haerter, Ergin Dilekoz, Hwa Kyoung Shin, Sean Savitz, Christian Waeber, Arn M. J. M. van den Maagdenberg, Michel Ferrari, Michael A. Moskowitz, Cenk Ayata. Severe and prolonged neurological deficits after cortical spreading depression in Familial Hemiplegic Migraine-1 (R192Q) knock-in mice. SFN 2007. 2007.
  120. Chiho Kudo, Michael A. Moskowitz, Cenk Ayata. The impact of anesthetics and normobaric hyperoxia on susceptibility to cortical spreading depression. BRAIN'07. 2007.
  121. Hwa Kyoung Shin, Ph.D., Phillip B. Jones, Ph.D., Monica Garcia-Alloza, Ph.D., Laura Borrelli, B.S., Steven M. Greenberg, M.D., Ph.D., Brian J. Bacskai, Ph.D., Matthew P. Frosch, M.D., Ph.D., Bradley T. Hyman, M.D., Ph.D., Michael A. Moskowitz, M.D., Cenk Ayata, M.D. AGE-DEPENDENT CEREBROVASCULAR DYSFUNCTION IN A TRANSGENIC MOUSE MODEL OF CEREBRAL AMYLOID ANGIOPATHY. Cerebral Amyloid Angiopathy: emerging concepts. 2007.
  122. Hwa Kyoung Shin, Monica Garcia-Alloza, Phillip B. Jones, Laura Borrelli, Brian J. Bacskai, Matthew P. Frosch, Bradley T. Hyman, Michael A. Moskowitz, Cenk Ayata. Age-dependent cerebrovascular dysfunction in Tg2576 transgenic mouse model of human cerebral amyloid angiopathy. BRAIN'7. 2007.
  123. Hwa Kyoung Shin, James A. Lapointe II, Dmitriy N. Atochin, Michael A. Moskowitz, Paul L. Huang, Cenk Ayata. Hypercholesterolemia worsens the blood flow deficit in focal cerebral ischemia in the absence of atherosclerosis. BRAIN'07. 2007.
  124. Shin HK, Salomone S, Potts EM, Lee SW, Millican E, Noma K, Huang PL, Boas DA, Liao JK, Moskowitz MA, Ayata C. Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms. J Cereb Blood Flow Metab. 2007 May; 27(5):998-1009. PMID: 17033691; PMCID: PMC2614438.
  125. Ayata C, Jin H, Kudo C, Dalkara T, Moskowitz MA. Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol. 2006 Apr; 59(4):652-61. PMID: 16450381.
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  126. Ay H, Koroshetz WJ, Benner T, Vangel MG, Melinosky C, Arsava EM, Ayata C, Zhu M, Schwamm LH, Sorensen AG. Neuroanatomic correlates of stroke-related myocardial injury. Neurology. 2006 May 09; 66(9):1325-9. PMID: 16525122.
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  127. Shin HK, Jones PB, Dunn AK, Boas DA, Moskowitz MA, Ayata C. Mild induced hypertension improves cerebral blood flow and oxygen metabolism in acute focal ischemia: a combined laser speckle flowmetry and multispectral reflectance imaging study. Society for Neuroscience Annual Meeting 2006. 2006.
  128. Haerter K, Kudo C, Ferrari MD, van den Maagdenberg AMJM, Moskowitz MA, Ayata C. Susceptibility to cortical spreading depression in Familial Hemiplegic Migraine-1 (R192Q) knockin mice: gene-dosage relationship and modulation by female sex. Society for Neuroscience Annual Meeting. 2006.
  129. Ayata C, Shin HK, Atochin DN, Huang PL, Moskowitz MA. Endothelial nitric oxide synthase S1179 phosphorylation improves cerebral blood flow and metabolic rate of oxygen, and reduces infarct size in focal cerebral ischemia. Society for Neuroscience Annual Meeting. 2006.
  130. Kudo C, Haerter K, Moskowitz MA, Ayata C. Estrogen modulates the susceptibility to cortical spreading depression, in vivo. Society for Neuroscience Annual Meeting. 2006.
  131. Zhou Z, Haerter K, Nishimura M, Shin HK, Ferrari MD, van den Maagdenberg AMJM, Moskowitz MA, Ayata C. Focal cerebral ischemia in Familial Hemiplegic Migraine-1 (R192Q) knockin mice. Society for Neuroscience Annual Meeting. 2006.
  132. Shin HK, Dunn AK, Jones PB, Boas DA, Moskowitz MA, Ayata C. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab. 2006 Aug; 26(8):1018-30. PMID: 16340958.
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  133. Ayata C, Moskowitz MA. Cortical spreading depression confounds concentration-dependent pial arteriolar dilation during N-methyl-D-aspartate superfusion. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1837-41. PMID: 16299263.
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  134. Haerter K, Ayata C, Moskowitz MA. Cortical spreading depression: a model for understanding migraine biology and future drug targets. Headache Currents. 2005; 2(5):1-7.
  135. Shin HK, Jones PB, Dunn AK, Boas DA, Moskowitz MA, Ayata C. Normobaric Hyperoxia Increases Oxygenation in Focal Ischemic Core. Society for Neuroscience Annual Meeting. 2005.
  136. Shin HK, Jones PB, Dunn AK, Boas DA, Moskowitz MA, Ayata C. Simultaneous multimodal optical imaging of cerebral blood flow and oxygenation in focal ischemic core and penumbra in mice. International Society for Cerebral Blood Flow and Metabolism Brain'05 Meeting. 2005.
  137. Jones PB, Shin HK, Dunn AK, Hyman BT, Boas DA, Moskowitz MA, Ayata C. Simultaneous, time resolved blood volume, oxygenation, and velocity imaging in mouse cortex. 2005.
  138. Ayata C, Badjatia N, Chou S, Nogueira RG, Smith EE, Carter BS, Ogilvy CS, Rordorf G. A randomized, double-blind, placebo-controlled trial of simvastatin on subarachnoid hemorrhage-induced vasospasm. Neurocritical Care Society Annual Meeting. 2005.
  139. Ayata C, Badjatia N, Chou S, Nogueira RG, Smith EE, Carter BS, Ogilvy CS, Rordorf G. A randomized, double-blind, placebo-controlled trial of simvastatin on subarachnoid hemorrhage-induced vasospasm. International Stroke Conference. 2005.
  140. Ayata C, Shin HK, Salomone S, Ozdemir-Gursoy Y, Boas DA, Dunn AK, Moskowitz MA. Pronounced hypoperfusion during spreading depression in mouse cortex. J Cereb Blood Flow Metab. 2004 Oct; 24(10):1172-82. PMID: 15529018.
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  141. Atochin DN, Murciano JC, Gürsoy-Ozdemir Y, Krasik T, Noda F, Ayata C, Dunn AK, Moskowitz MA, Huang PL, Muzykantov VR. Mouse model of microembolic stroke and reperfusion. Stroke. 2004 Sep; 35(9):2177-82. PMID: 15256680.
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  142. Ayata C, Dunn AK, Gursoy-OZdemir Y, Huang Z, Boas DA, Moskowitz MA. Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex. J Cereb Blood Flow Metab. 2004 Jul; 24(7):744-55. PMID: 15241182.
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  143. Badjatia N, O'Donnell J, Baker JR, Huang D, Ayata C, Greer DM, Carter BS, Ogilvy CS, McDonald CT. Achieving normothermia in patients with febrile subarachnoid hemorrhage: feasibility and safety of a novel intravascular cooling catheter. Neurocrit Care. 2004; 1(2):145-56. PMID: 16174910.
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  144. Ayata C, Rordorf G. . Craniocervical Endovascular Stenting and Angioplasty. Karen L. Furie, Peter J. Kelley, eds. Handbook of Stroke Prevention in Clinical Practice. 2004; 167-186.
  145. Atochin DN, Ayata C, Salomone S, Noda F, Moskowitz MA, Huang PL. Cerebral ischemia-reperfusion injury on ApoE/eNOS deficient mice on western diet. Society for Neuroscience Annual Meeting. 2004.
  146. Ropper AH, Ayata C, Adelman L. Vasculitis of the spinal cord. Arch Neurol. 2003 Dec; 60(12):1791-4. PMID: 14676059.
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  147. Ayata C, Ropper AH. Intensive care management of specific stroke treatment. Adv Neurol. 2003; 92:361-77. PMID: 12760202.
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  148. Qureshi AI, Suarez JI, Yahia AM, Mohammad Y, Uzun G, Suri MF, Zaidat OO, Ayata C, Ali Z, Wityk RJ. Timing of neurologic deterioration in massive middle cerebral artery infarction: a multicenter review. Crit Care Med. 2003 Jan; 31(1):272-7. PMID: 12545028.
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  149. Topcuoglu MA, Ayata C, Koroshetz WJ, Carter BS, Ogilvy CS, Buonanno FS, Singhal AB. . Effects of Common Vasoactive Drug Use on Vasospasm after Aneurysmal Subarachnoid Hemorrhage. 28th International Stroke Conference, Phoenix. 2003.
  150. Ayata C, Atochin DN, Huang Z, Huang PL, Dunn AK, Boad DA, Moskowitz MA. . Impaired cerebrovascular responses in ApoE-deficient mice. Society for Neuroscience Annual Meeting. 2003.
  151. Ayata C, Ropper AH. Ischaemic brain oedema. J Clin Neurosci. 2002 Mar; 9(2):113-24. PMID: 11922696.
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  152. Toran MB, Ayata C, Jones HR. . Low intracranial pressure headache. Cobb Assembly, Boston. 2001.
  153. Ayata C, Shimizu-Sasamata M, Lo EH, Noebels JL, Moskowitz MA. Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels. Neuroscience. 2000; 95(3):639-45. PMID: 10670432.
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  154. Mandeville JB, Marota JJ, Ayata C, Moskowitz MA, Weisskoff RM, Rosen BR. MRI measurement of the temporal evolution of relative CMRO(2) during rat forepaw stimulation. Magn Reson Med. 1999 Nov; 42(5):944-51. PMID: 10542354.
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  155. Mandeville JB, Marota JJ, Ayata C, Zaharchuk G, Moskowitz MA, Rosen BR, Weisskoff RM. Evidence of a cerebrovascular postarteriole windkessel with delayed compliance. J Cereb Blood Flow Metab. 1999 Jun; 19(6):679-89. PMID: 10366199.
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  156. Browne SE, Ayata C, Huang PL, Moskowitz MA, Beal MF. The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice. J Cereb Blood Flow Metab. 1999 Feb; 19(2):144-8. PMID: 10027769.
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  157. Marota JJ, Ayata C, Moskowitz MA, Weisskoff RM, Rosen BR, Mandeville JB. Investigation of the early response to rat forepaw stimulation. Magn Reson Med. 1999 Feb; 41(2):247-52. PMID: 10080270.
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  158. Dalkara T, Ayata C, Moskowitz MA. Constitutive nitric oxide synthase and ischemic/excitotoxic brain injury. Ruffolo RR Jr., Feuerstein G, Hunter AJ, Poste G, BW Metcalf BW, eds. Inflammatory Cells and Mediators in CNS Diseases. 1999; 85-96.
  159. Ayata C, Thaler DE. . A 29 year old female with ‘frog heart’ and first stroke. Massachusetts Neurological Association Annual Meeting. 1999.
  160. Ayata C, Guo MZ, Hreib K. Neurological complications of TTP: importance of early diagnosis and intervention. Cobb Assembly, Boston. 1999.
  161. Meng W, Ayata C, Waeber C, Huang PL, Moskowitz MA. Neuronal NOS-cGMP-dependent ACh-induced relaxation in pial arterioles of endothelial NOS knockout mice. Am J Physiol. 1998 Feb; 274(2 Pt 2):H411-5. PMID: 9486242.
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  162. Ayata C, Ayata G, Hara H, Matthews RT, Beal MF, Ferrante RJ, Endres M, Kim A, Christie RH, Waeber C, Huang PL, Hyman BT, Moskowitz MA. Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice. J Neurosci. 1997 Sep 15; 17(18):6908-17. PMID: 9278526.
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  163. Hara H, Ayata C, Huang PL, Waeber C, Ayata G, Fujii M, Moskowitz MA. [3H]L-NG-nitroarginine binding after transient focal ischemia and NMDA-induced excitotoxicity in type I and type III nitric oxide synthase null mice. J Cereb Blood Flow Metab. 1997 May; 17(5):515-26. PMID: 9183289.
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  164. Demirci M, Ayata C, Dalkara T, Erdemli G, Onur R. Monitoring cellular edema at single-neuron level by electrical resistance measurements. J Neurosci Methods. 1997 Apr 04; 72(2):175-81. PMID: 9133582.
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  165. Okamoto H, Meng W, Ma J, Ayata C, Roman RJ, Bosnjak ZJ, Kampine JP, Huang PL, Moskowitz MA, Hudetz AG. Isoflurane-induced cerebral hyperemia in neuronal nitric oxide synthase gene deficient mice. Anesthesiology. 1997 Apr; 86(4):875-84. PMID: 9105232.
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  166. Hara H, Friedlander RM, Gagliardini V, Ayata C, Fink K, Huang Z, Shimizu-Sasamata M, Yuan J, Moskowitz MA. Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):2007-12. PMID: 9050895; PMCID: PMC20033.
  167. Moskowitz MA, Ayata C. A neurological double-header: Spontaneous mouse mutations provide novel insights and new implications for migraine and epilepsy. Neurology Network Commentary. 1997; 1:265-268.
  168. J. Marota, J.B. Mandeville, C. Ayata, B. Kosovsky, R. Weissleder, S. Hyman, M.A. Moskowitz, R.M. Weisskoff, B.R. Rosen. Activation of rat brain by cocaine: Functional imaging with BOLD and cerebral blood volume. International Society for Magnetic Resonance in Medicine, 5th Scientific Meeting. 1997.
  169. Ma J, Meng W, Ayata C, Huang PL, Fishman MC, Moskowitz MA. L-NNA-sensitive regional cerebral blood flow augmentation during hypercapnia in type III NOS mutant mice. Am J Physiol. 1996 Oct; 271(4 Pt 2):H1717-9. PMID: 8897969.
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  170. Huang Z, Huang PL, Ma J, Meng W, Ayata C, Fishman MC, Moskowitz MA. Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine. J Cereb Blood Flow Metab. 1996 Sep; 16(5):981-7. PMID: 8784243.
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  171. Meng W, Ma J, Ayata C, Hara H, Huang PL, Fishman MC, Moskowitz MA. ACh dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms. Am J Physiol. 1996 Sep; 271(3 Pt 2):H1145-50. PMID: 8853353.
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  172. Ayata C, Ma J, Meng W, Huang P, Moskowitz MA. L-NA-sensitive rCBF augmentation during vibrissal stimulation in type III nitric oxide synthase mutant mice. J Cereb Blood Flow Metab. 1996 Jul; 16(4):539-41. PMID: 8964791.
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  173. Ma J, Ayata C, Huang PL, Fishman MC, Moskowitz MA. Regional cerebral blood flow response to vibrissal stimulation in mice lacking type I NOS gene expression. Am J Physiol. 1996 Mar; 270(3 Pt 2):H1085-90. PMID: 8780207.
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  174. Dalkara T, Ayata C, Demirci M, Erdemli G, Onur R. Effects of cerebral ischemia on N-methyl-D-aspartate and dihydropyridine-sensitive calcium currents. An electrophysiological study in the rat hippocampus in situ. Stroke. 1996 Jan; 27(1):127-33. PMID: 8553388.
    View in: PubMed
  175. Ayata C, Moskowitz MA. . Ketamine antagonizes NO release from cerebral cortex after middle cerebral artery ligation. Stroke. 1996; 27:752.
  176. Moskowitz MA, Ayata C. . Potentiation of oxygen-glucose deprivation-induced neuronal death after induction of iNOS. Stroke. 1996; 27:1591.
  177. Onur R, Bozdagi O, Ayata C. Effects of aconitine on neurotransmitter release in the rat neuromuscular junction. Neuropharmacology. 1995 Sep; 34(9):1139-45. PMID: 8532184.
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  178. Lee WS, Limmroth V, Ayata C, Cutrer FM, Waeber C, Yu X, Moskowitz MA. Peripheral GABAA receptor-mediated effects of sodium valproate on dural plasma protein extravasation to substance P and trigeminal stimulation. Br J Pharmacol. 1995 Sep; 116(1):1661-7. PMID: 8564234; PMCID: PMC1908914.
  179. Dalkara T, Ayata C, Erdemli G, Onur R. . Carbamazepine and phenytoin inhibit NMDA receptor-mediated currents in the rat hippocampus. Society for Neuroscience Annual Meeting. 1992.
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