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James R. Baylis, Ph.D.

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Mentoring
Available: 02/18/22, Expires: 06/01/22

Oral formulations are the patient-preferred way to take drugs. Oral formulations of small molecules have high bioavailability, but large molecules and biologics have very low bioavailability compared to intravenous and intramuscular injections. Devices and formulations which can overcome the transport barriers in the gastrointestinal tract could enable new strategies for oral delivery of biologics. The student would conceive, design, build, and test new concepts for oral delivery of biologics. This could involve any fabrication techniques (e.g., machining, 3D modeling and printing) and in vitro and ex vivo drug delivery assays. Skills in any of these are appreciated.


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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ali-Mohamad N, Cau MF, Baylis JR, Semple H, Kastrup CJ, Beckett A. Videoconferencing for Large Animal Trauma Experiments During COVID-19: A Cross-Continent Experience. Mil Med. 2022 Mar 01. PMID: 35231116.
    Citations:    Fields:    
  2. Cau MF, Ali-Mohamad N, Baylis JR, Zenova V, Khavari A, Peng N, McFadden A, Donnellan F, Owen DR, Schaeffer DF, Nagaswami C, Litvinov RI, Weisel JW, Rezende-Neto J, Semple HA, Beckett A, Kastrup CJ. Percutaneous delivery of self-propelling hemostatic powder for managing non-compressible abdominal hemorrhage: a proof-of-concept study in swine. Injury. 2022 Jan 15. PMID: 35067343.
    Citations:    Fields:    
  3. Ali-Mohamad N, Cau M, Baylis J, Zenova V, Semple H, Beckett A, McFadden A, Donnellan F, Kastrup C. Severe upper gastrointestinal bleeding is halted by endoscopically delivered self-propelling thrombin powder: A porcine pilot study. Endosc Int Open. 2021 May; 9(5):E693-E698. PMID: 33937509.
    Citations: 1     
  4. Chan KYT, Yong ASM, Wang X, Ringgold KM, St John AE, Baylis JR, White NJ, Kastrup CJ. The adhesion of clots in wounds contributes to hemostasis and can be enhanced by coagulation factor XIII. Sci Rep. 2020 11 18; 10(1):20116. PMID: 33208779.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Mazinani N, Strilchuk AW, Baylis JR, Hur WS, Jefferies WA, Kastrup CJ. Bleeding is increased in amyloid precursor protein knockout mouse. Res Pract Thromb Haemost. 2020 Jul; 4(5):823-828. PMID: 32685890.
    Citations: 1     
  6. Baylis JR, Lee MM, St John AE, Wang X, Simonson E, Cau M, Kazerooni A, Gusti V, Statz ML, Yoon JSJ, Liggins RT, White NJ, Kastrup CJ. Topical tranexamic acid inhibits fibrinolysis more effectively when formulated with self-propelling particles. J Thromb Haemost. 2019 10; 17(10):1645-1654. PMID: 31145837.
    Citations: 1     Fields:    Translation:HumansAnimals
  7. Yeon JH, Mazinani N, Schlappi TS, Chan KY, Baylis JR, Smith SA, Donovan AJ, Kudela D, Stucky GD, Liu Y, Morrissey JH, Kastrup CJ. Localization of Short-Chain Polyphosphate Enhances its Ability to Clot Flowing Blood Plasma. Sci Rep. 2017 02 10; 7:42119. PMID: 28186112.
    Citations: 4     Fields:    Translation:HumansCells
  8. Baylis JR, St John AE, Wang X, Lim EB, Statz ML, Chien D, Simonson E, Stern SA, Liggins RT, White NJ, Kastrup CJ. Self-Propelled Dressings Containing Thrombin and Tranexamic Acid Improve Short-Term Survival in a Swine Model of Lethal Junctional Hemorrhage. Shock. 2016 09; 46(3 Suppl 1):123-8. PMID: 27206277.
    Citations: 5     Fields:    Translation:Animals
  9. Baylis JR, Chan KY, Kastrup CJ. Halting hemorrhage with self-propelling particles and local drug delivery. Thromb Res. 2016 May; 141 Suppl 2:S36-9. PMID: 27207421.
    Citations: 3     Fields:    Translation:HumansAnimals
  10. Baylis JR, Yeon JH, Thomson MH, Kazerooni A, Wang X, St John AE, Lim EB, Chien D, Lee A, Zhang JQ, Piret JM, Machan LS, Burke TF, White NJ, Kastrup CJ. Self-propelled particles that transport cargo through flowing blood and halt hemorrhage. Sci Adv. 2015 Oct; 1(9):e1500379. PMID: 26601282.
    Citations: 25     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.