Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Xu Zhou, Ph.D.

Title
Institution
Department
Address
Profile Picture

Biography
Peking University, Beijing, ChinaBS06/2006Biological Sciences
Harvard University, Cambridge, MAPhD06/2013Biochemistry
Yale School of Medicine, New Haven, CTPostdoc12/2020Immunobiology
2014 - 2017
Jane Coffin Childs Postdoctoral fellowship

Overview
Xu Zhou is a Principal Investigator in the Division of Gastroenterology, Hepatology and Nutrition, at the department of Pediatrics of Boston Childrens Hospital, and a member of faculty at Harvard Medical School. Dr. Zhou earned a B.S. from Peking University studying viral capsule protein of Hepatitis virus B. He obtained a Ph.D. with Dr. Erin OShea in the Department of Molecular and Cellular Biology at Harvard University, studying systems biology and transcriptional regulation. He then completed his postdoctoral training with Dr. Ruslan Medzhitov in the Department of Immunobiology at Yale University School of Medicine, investigating the mechanisms of tissue homeostasis and inflammation. The Zhou lab opened its door at Boston Childrens Hospital in 2021. The long-term goal of the Zhou lab is to decipher molecular and cellular mechanisms regulating tissue homeostasis and inflammation, and to understand how dysregulation of these processes leads to inflammatory disorders. To achieve this goal, they apply interdisciplinary approaches across immunology, systems biology, molecular and cellular biology, with a focus on the communication between immune and non-immune cell types and between cells and their microenvironment.

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Meizlish ML, Franklin RA, Zhou X, Medzhitov R. Tissue Homeostasis and Inflammation. Annu Rev Immunol. 2021 Mar 02. PMID: 33651964.
    Citations:    Fields:    
  2. Adler M, Mayo A, Zhou X, Franklin RA, Meizlish ML, Medzhitov R, Kallenberger SM, Alon U. Principles of Cell Circuits for Tissue Repair and Fibrosis. iScience. 2020 Feb 21; 23(2):100841. PMID: 32058955.
    Citations: 6     
  3. Allen NC, Philip NH, Hui L, Zhou X, Franklin RA, Kong Y, Medzhitov R. Desynchronization of the molecular clock contributes to the heterogeneity of the inflammatory response. Sci Signal. 2019 03 05; 12(571). PMID: 30837303.
    Citations: 7     Fields:    Translation:AnimalsCells
  4. Wang J, Sun J, Liu LN, Flies DB, Nie X, Toki M, Zhang J, Song C, Zarr M, Zhou X, Han X, Archer KA, O'Neill T, Herbst RS, Boto AN, Sanmamed MF, Langermann S, Rimm DL, Chen L. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nat Med. 2019 04; 25(4):656-666. PMID: 30833750.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  5. Li MD, Vera NB, Yang Y, Zhang B, Ni W, Ziso-Qejvanaj E, Ding S, Zhang K, Yin R, Wang S, Zhou X, Fang EX, Xu T, Erion DM, Yang X. Adipocyte OGT governs diet-induced hyperphagia and obesity. Nat Commun. 2018 11 30; 9(1):5103. PMID: 30504766.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  6. Adler M, Mayo A, Zhou X, Franklin RA, Jacox JB, Medzhitov R, Alon U. Endocytosis as a stabilizing mechanism for tissue homeostasis. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):E1926-E1935. PMID: 29429964.
    Citations: 5     Fields:    Translation:Cells
  7. Zhou X, Franklin RA, Adler M, Jacox JB, Bailis W, Shyer JA, Flavell RA, Mayo A, Alon U, Medzhitov R. Circuit Design Features of a Stable Two-Cell System. Cell. 2018 02 08; 172(4):744-757.e17. PMID: 29398113.
    Citations: 48     Fields:    Translation:AnimalsCells
  8. Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nat Med. 2017 Aug; 23(8):997-1003. PMID: 28692063.
    Citations: 41     Fields:    Translation:Animals
  9. He BZ, Zhou X, O'Shea EK. Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway. Elife. 2017 05 09; 6. PMID: 28485712.
    Citations: 7     Fields:    Translation:Animals
  10. Zhou X, Blocker AW, Airoldi EM, O'Shea EK. A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution. Elife. 2016 09 13; 5. PMID: 27623011.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  11. Zhang F, Li X, Zhang Y, Coates B, Zhou XJ, Cheng D. Bacterial symbionts, Buchnera, and starvation on wing dimorphism in English grain aphid, Sitobion avenae (F.) (Homoptera: Aphididae). Front Physiol. 2015; 6:155. PMID: 26042046.
    Citations: 5     
  12. Su T, Bondar T, Zhou X, Zhang C, He H, Medzhitov R. Two-signal requirement for growth-promoting function of Yap in hepatocytes. Elife. 2015 Feb 10; 4. PMID: 25667983.
    Citations: 20     Fields:    Translation:AnimalsCells
  13. Zhou X, O'Shea EK. Integrated approaches reveal determinants of genome-wide binding and function of the transcription factor Pho4. Mol Cell. 2011 Jun 24; 42(6):826-36. PMID: 21700227.
    Citations: 57     Fields:    Translation:AnimalsCells
  14. Lian M, Zhou X, Chen B, Li C, Gu X, Luo M, Zheng X. Identification of the critical regions in hepatitis B virus preS required for its stability. J Pept Sci. 2008 Mar; 14(3):307-12. PMID: 17918766.
    Citations: 5     Fields:    Translation:Cells
  15. Lian M, Zhou X, Wei L, Qiu S, Zhou T, Li L, Gu X, Luo M, Zheng X. Serum levels of preS antigen (HBpreSAg) in chronic hepatitis B virus infected patients. Virol J. 2007 Sep 24; 4:93. PMID: 17892580.
    Citations: 2     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Zhou's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (113)
Explore
_
Co-Authors (2)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.