Assistant Professor of Pediatrics
Boston Children's Hospital
|Peking University, Beijing, China||BS||06/2006||Biological Sciences|
|Harvard University, Cambridge, MA||PhD||06/2013||Biochemistry|
|Yale School of Medicine, New Haven, CT||Postdoc||12/2020||Immunobiology|
2014 - 2017
Jane Coffin Childs Postdoctoral fellowship
Xu Zhou is a Principal Investigator in the Division of Gastroenterology, Hepatology and Nutrition, at the department of Pediatrics of Boston Childrens Hospital, and a member of faculty at Harvard Medical School. Dr. Zhou earned a B.S. from Peking University studying viral capsule protein of Hepatitis virus B. He obtained a Ph.D. with Dr. Erin OShea in the Department of Molecular and Cellular Biology at Harvard University, studying systems biology and transcriptional regulation. He then completed his postdoctoral training with Dr. Ruslan Medzhitov in the Department of Immunobiology at Yale University School of Medicine, investigating the mechanisms of tissue homeostasis and inflammation. The Zhou lab opened its door at Boston Childrens Hospital in 2021. The long-term goal of the Zhou lab is to decipher molecular and cellular mechanisms regulating tissue homeostasis and inflammation, and to understand how dysregulation of these processes leads to inflammatory disorders. To achieve this goal, they apply interdisciplinary approaches across immunology, systems biology, molecular and cellular biology, with a focus on the communication between immune and non-immune cell types and between cells and their microenvironment.
Available: 04/01/22, Expires: 03/01/26
Our immune system is specialized into sensing and responding to infections and injuries. Immune cells are also equipped with sensors that monitor tissue microenvironment, such pH. Interstitial pH is often impacted by inflammatory response, injury and cancer. We are interested in dissecting how changes in pH modulate immune functions as a potential strategy to control inflammation. This project will employ cell culture, animal models and immunology experimental techniques. Students will be working closely with PI and members in the lab to design and contact experiments, analyze, summarize and present their findings. Knowledge of immunology, and prior experience of cell culture and animal models is preferred.
Available: 04/01/22, Expires: 03/01/25
Although immune cells are well-known for their mobility, it's becoming clear that tissue resident immune cells, such as macrophages, are organized into unique spatial patterns within tissues. Recently, the interactions between myeloid and stromal cells are found associated with several inflammatory disorders, including Crohns disease and Ulcerative Colitis. We are interested in uncovering cellular mechanisms that regulate the interactions between myeloid and stromal cells, and how such organization dictates their homeostatic and inflammatory functions. This project will employ cell culture, molecular cloning, gene editing and a variety of cell biology and immunology experimental techniques. Students will be working closely with PI and members in the lab to design and contact experiments, analyze, summarize and present their findings. Knowledge of molecular and cellular biology, immunology, and prior experience of cell culture is preferred.
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