Harvard Catalyst Profiles

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Yuki Sugimoto, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kawaguchi C, Shintani N, Hayata-Takano A, Hatanaka M, Kuromi A, Nakamura R, Yamano Y, Shintani Y, Nagai K, Tsuchiya S, Sugimoto Y, Ichikawa A, Okuno Y, Urade Y, Hirai H, Nagata KY, Nakamura M, Narumiya S, Nakazawa T, Kasai A, Ago Y, Takuma K, Baba A, Hashimoto H. Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice. Commun Biol. 2020 10 08; 3(1):557. PMID: 33033338.
    Citations: 1     Translation:Animals
  2. Norel X, Sugimoto Y, Ozen G, Abdelazeem H, Amgoud Y, Bouhadoun A, Bassiouni W, Goepp M, Mani S, Manikpurage HD, Senbel A, Longrois D, Heinemann A, Yao C, Clapp LH. International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions. Pharmacol Rev. 2020 10; 72(4):910-968. PMID: 32962984.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  3. Sugimoto Y, Endo D, Aratani Y. Mice Deficient in NOX2 Display Severe Thymic Atrophy, Lymphopenia, and Reduced Lymphopoiesis in a Zymosan-Induced Model of Systemic Inflammation. Inflammation. 2021 Feb; 44(1):371-382. PMID: 32939668.
    Citations: 1     Fields:    Translation:Animals
  4. Iwasaki R, Tsuge K, Kishimoto K, Hayashi Y, Iwaana T, Hohjoh H, Inazumi T, Kawahara A, Tsuchiya S, Sugimoto Y. Essential role of prostaglandin E2 and the EP3 receptor in lymphatic vessel development during zebrafish embryogenesis. Sci Rep. 2019 05 21; 9(1):7650. PMID: 31114004.
    Citations:    Fields:    Translation:Animals
  5. Toyoda Y, Morimoto K, Suno R, Horita S, Yamashita K, Hirata K, Sekiguchi Y, Yasuda S, Shiroishi M, Shimizu T, Urushibata Y, Kajiwara Y, Inazumi T, Hotta Y, Asada H, Nakane T, Shiimura Y, Nakagita T, Tsuge K, Yoshida S, Kuribara T, Hosoya T, Sugimoto Y, Nomura N, Sato M, Hirokawa T, Kinoshita M, Murata T, Takayama K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T. Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface. Nat Chem Biol. 2019 01; 15(1):18-26. PMID: 30510193.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  6. Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N. Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity. Cancer Discov. 2017 05; 7(5):522-538. PMID: 28202625.
    Citations: 86     Fields:    Translation:HumansAnimals
  7. Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C. Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis. J Biol Chem. 2015 Dec 11; 290(50):29781-93. PMID: 26475855.
    Citations: 13     Fields:    Translation:AnimalsCells
  8. Ikeda K, Tomimoto S, Tsuchiya S, Hamagami KI, Shintani N, Sugimoto Y, Ichikawa A, Kasai A, Nakazawa T, Nagayasu K, Hayata-Takano A, Baba A, Hashimoto H. Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice. Biochem Biophys Rep. 2015 Jul; 2:179-183. PMID: 29124161.
  9. Higashi S, Katagi K, Shintani N, Ikeda K, Sugimoto Y, Tsuchiya S, Inoue N, Tanaka S, Koumoto M, Kasai A, Nakazawa T, Hayata-Takano A, Hamagami K, Tomimoto S, Yoshida T, Ohkubo T, Nagayasu K, Ago Y, Onaka Y, Hashimoto R, Ichikawa A, Baba A, Hashimoto H. p13 overexpression in pancreatic ß-cells ameliorates type 2 diabetes in high-fat-fed mice. Biochem Biophys Res Commun. 2015 Jun 12; 461(4):612-7. PMID: 25912136.
    Citations: 5     Fields:    Translation:AnimalsCells
  10. Kawahara K, Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y. Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors. Biochim Biophys Acta. 2015 Apr; 1851(4):414-21. PMID: 25038274.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  11. Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T. 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. J Exp Med. 2014 Jun 02; 211(6):1063-78. PMID: 24821912.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  12. Morimoto K, Shirata N, Taketomi Y, Tsuchiya S, Segi-Nishida E, Inazumi T, Kabashima K, Tanaka S, Murakami M, Narumiya S, Sugimoto Y. Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation. J Immunol. 2014 Feb 01; 192(3):1130-7. PMID: 24342806.
    Citations: 32     Fields:    Translation:AnimalsCells
  13. Nakazawa S, Sakanaka M, Furuta K, Natsuhara M, Takano H, Tsuchiya S, Okuno Y, Ohtsu H, Nishibori M, Thurmond RL, Hirasawa N, Nakayama K, Ichikawa A, Sugimoto Y, Tanaka S. Histamine synthesis is required for granule maturation in murine mast cells. Eur J Immunol. 2014 Jan; 44(1):204-14. PMID: 24002822.
    Citations: 15     Fields:    Translation:AnimalsCells
  14. Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S, Murakami M. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol. 2013 Jun; 14(6):554-63. PMID: 23624557.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  15. Nakagawa N, Yuhki K, Kawabe J, Fujino T, Takahata O, Kabara M, Abe K, Kojima F, Kashiwagi H, Hasebe N, Kikuchi K, Sugimoto Y, Narumiya S, Ushikubi F. The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice. Kidney Int. 2012 Jul; 82(2):158-71. PMID: 22513820.
    Citations: 31     Fields:    Translation:AnimalsCells
  16. Hoshino T, Namba T, Takehara M, Murao N, Matsushima T, Sugimoto Y, Narumiya S, Suzuki T, Mizushima T. Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor. J Neurochem. 2012 Mar; 120(5):795-805. PMID: 22044482.
    Citations: 14     Fields:    Translation:Animals
  17. Takano H, Furuta K, Yamashita K, Sakanaka M, Itano N, Gohda E, Nakayama K, Kimata K, Sugimoto Y, Ichikawa A, Tanaka S. Restriction of mast cell proliferation through hyaluronan synthesis by co-cultured fibroblasts. Biol Pharm Bull. 2012; 35(3):408-12. PMID: 22382329.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Inazumi T, Shirata N, Morimoto K, Takano H, Segi-Nishida E, Sugimoto Y. Prostaglandin E2-EP4 signaling suppresses adipocyte differentiation in mouse embryonic fibroblasts via an autocrine mechanism. J Lipid Res. 2011 Aug; 52(8):1500-8. PMID: 21646392.
    Citations: 16     Fields:    Translation:AnimalsCells
  19. Mizuguchi S, Ohno T, Hattori Y, Ae T, Minamino T, Satoh T, Arai K, Saeki T, Hayashi I, Sugimoto Y, Narumiya S, Saigenji K, Majima M. Roles of prostaglandin E2-EP1 receptor signaling in regulation of gastric motor activity and emptying. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1078-86. PMID: 20798358.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Tamba S, Yodoi R, Morimoto K, Inazumi T, Sukeno M, Segi-Nishida E, Okuno Y, Tsujimoto G, Narumiya S, Sugimoto Y. Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling. Biochimie. 2010 Jun; 92(6):665-75. PMID: 20399827.
    Citations: 6     Fields:    Translation:AnimalsCells
  21. Katoh H, Hosono K, Ito Y, Suzuki T, Ogawa Y, Kubo H, Kamata H, Mishima T, Tamaki H, Sakagami H, Sugimoto Y, Narumiya S, Watanabe M, Majima M. COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. Am J Pathol. 2010 Mar; 176(3):1469-83. PMID: 20110411.
    Citations: 49     Fields:    Translation:AnimalsCells
  22. Ichikawa A, Sugimoto Y, Tanaka S. Molecular biology of histidine decarboxylase and prostaglandin receptors. Proc Jpn Acad Ser B Phys Biol Sci. 2010; 86(8):848-66. PMID: 20948178.
    Citations: 10     Fields:    Translation:HumansAnimals
  23. Kubo H, Hosono K, Suzuki T, Ogawa Y, Kato H, Kamata H, Ito Y, Amano H, Kato T, Sakagami H, Hayashi I, Sugimoto Y, Narumiya S, Watanabe M, Majima M. Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis. Biomed Pharmacother. 2010 Feb; 64(2):101-6. PMID: 20034758.
    Citations: 16     Fields:    Translation:AnimalsCells
  24. Yamaoka K, Yano A, Kuroiwa K, Morimoto K, Inazumi T, Hatae N, Tabata H, Segi-Nishida E, Tanaka S, Ichikawa A, Sugimoto Y. Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner. Biochem Biophys Res Commun. 2009 Nov 27; 389(4):678-82. PMID: 19769944.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  25. Amano H, Ito Y, Suzuki T, Kato S, Matsui Y, Ogawa F, Murata T, Sugimoto Y, Senior R, Kitasato H, Hayashi I, Satoh Y, Narumiya S, Majima M. Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis. Cancer Sci. 2009 Dec; 100(12):2318-24. PMID: 19799610.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  26. Yao C, Sakata D, Esaki Y, Li Y, Matsuoka T, Kuroiwa K, Sugimoto Y, Narumiya S. Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat Med. 2009 Jun; 15(6):633-40. PMID: 19465928.
    Citations: 189     Fields:    Translation:AnimalsCells
  27. Hoshino T, Namba T, Takehara M, Nakaya T, Sugimoto Y, Araki W, Narumiya S, Suzuki T, Mizushima T. Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. J Biol Chem. 2009 Jul 03; 284(27):18493-502. PMID: 19407341.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  28. Yodoi R, Tamba S, Morimoto K, Segi-Nishida E, Nishihara M, Ichikawa A, Narumiya S, Sugimoto Y. RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly. Endocrinology. 2009 Jul; 150(7):3345-52. PMID: 19342461.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  29. Ogawa Y, Suzuki T, Oikawa A, Hosono K, Kubo H, Amano H, Ito Y, Kitasato H, Hayashi I, Kato T, Sugimoto Y, Narumiya S, Watanabe M, Majima M. Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth. Biochem Biophys Res Commun. 2009 May 15; 382(4):720-5. PMID: 19318087.
    Citations: 11     Fields:    Translation:AnimalsCells
  30. Takano H, Nakazawa S, Shirata N, Tamba S, Furuta K, Tsuchiya S, Morimoto K, Itano N, Irie A, Ichikawa A, Kimata K, Nakayama K, Sugimoto Y, Tanaka S. Involvement of CD44 in mast cell proliferation during terminal differentiation. Lab Invest. 2009 Apr; 89(4):446-55. PMID: 19204665.
    Citations: 3     Fields:    Translation:AnimalsCells
  31. Sakanaka M, Tanaka S, Sugimoto Y, Ichikawa A. Essential role of EP3 subtype in prostaglandin E2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix. . 2008 Nov; 295(5):C1427-33. PMID: 18815228.
    Citations: 4     Translation:AnimalsCells
  32. Tamba S, Yodoi R, Segi-Nishida E, Ichikawa A, Narumiya S, Sugimoto Y. Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14539-44. PMID: 18794532.
    Citations: 18     Fields:    Translation:AnimalsCells
  33. Yano Y, Yano A, Oishi S, Sugimoto Y, Tsujimoto G, Fujii N, Matsuzaki K. Coiled-coil tag--probe system for quick labeling of membrane receptors in living cell. ACS Chem Biol. 2008 Jun 20; 3(6):341-5. PMID: 18533657.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  34. Yano Y, Shimbo T, Sugimoto Y, Matsuzaki K. Intracellular third loop-C-terminal tail interaction in prostaglandin EP3beta receptor. Biochem Biophys Res Commun. 2008 Jul 11; 371(4):846-9. PMID: 18474230.
    Citations:    Fields:    Translation:AnimalsCells
  35. Takano H, Nakazawa S, Okuno Y, Shirata N, Tsuchiya S, Kainoh T, Takamatsu S, Furuta K, Taketomi Y, Naito Y, Takematsu H, Kozutsumi Y, Tsujimoto G, Murakami M, Kudo I, Ichikawa A, Nakayama K, Sugimoto Y, Tanaka S. Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells. FEBS Lett. 2008 Apr 30; 582(10):1444-50. PMID: 18381075.
    Citations: 15     Fields:    Translation:AnimalsCells
  36. Tsuchiya H, Oka T, Nakamura K, Ichikawa A, Saper CB, Sugimoto Y. Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors. J Biol Chem. 2008 Apr 18; 283(16):11064-71. PMID: 18292084.
    Citations: 5     Fields:    Translation:AnimalsCells
  37. Yuhki K, Ushikubi F, Naraba H, Ueno A, Kato H, Kojima F, Narumiya S, Sugimoto Y, Matsushita M, Oh-Ishi S. Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy. J Pharmacol Exp Ther. 2008 May; 325(2):601-9. PMID: 18256172.
    Citations: 8     Fields:    Translation:Animals
  38. Hoshino T, Nakaya T, Homan T, Tanaka K, Sugimoto Y, Araki W, Narita M, Narumiya S, Suzuki T, Mizushima T. Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo. J Biol Chem. 2007 Nov 09; 282(45):32676-88. PMID: 17767011.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  39. Suzuki-Yamamoto T, Sugimoto Y, Ichikawa A, Ishimura K. Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells. Histochem Cell Biol. 2007 Oct; 128(4):317-22. PMID: 17674023.
    Citations: 2     Fields:    Translation:AnimalsCells
  40. Taketomi Y, Sunaga K, Tanaka S, Nakamura M, Arata S, Okuda T, Moon TC, Chang HW, Sugimoto Y, Kokame K, Miyata T, Murakami M, Kudo I. Impaired mast cell maturation and degranulation and attenuated allergic responses in Ndrg1-deficient mice. J Immunol. 2007 Jun 01; 178(11):7042-53. PMID: 17513753.
    Citations: 16     Fields:    Translation:AnimalsCells
  41. Furuta K, Nakayama K, Sugimoto Y, Ichikawa A, Tanaka S. Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815. J Biol Chem. 2007 May 04; 282(18):13438-46. PMID: 17360717.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  42. Sugimoto Y, Narumiya S. Prostaglandin E receptors. J Biol Chem. 2007 Apr 20; 282(16):11613-7. PMID: 17329241.
    Citations: 407     Fields:    Translation:HumansAnimalsCells
  43. Yokoyama U, Minamisawa S, Quan H, Ghatak S, Akaike T, Segi-Nishida E, Iwasaki S, Iwamoto M, Misra S, Tamura K, Hori H, Yokota S, Toole BP, Sugimoto Y, Ishikawa Y. Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus. J Clin Invest. 2006 Nov; 116(11):3026-34. PMID: 17080198.
    Citations: 51     Fields:    Translation:AnimalsCells
  44. Trivedi DB, Sugimoto Y, Loftin CD. Attenuated cyclooxygenase-2 expression contributes to patent ductus arteriosus in preterm mice. Pediatr Res. 2006 Dec; 60(6):669-74. PMID: 17065565.
    Citations: 8     Fields:    Translation:Animals
  45. Kim H, Arakawa H, Hatae N, Sugimoto Y, Matsumoto O, Osada T, Ichikawa A, Ikai A. Quantification of the number of EP3 receptors on a living CHO cell surface by the AFM. Ultramicroscopy. 2006 Jun-Jul; 106(8-9):652-62. PMID: 16677763.
    Citations: 9     Fields:    Translation:AnimalsCells
  46. Liu Y, Furuta K, Teshima R, Shirata N, Sugimoto Y, Ichikawa A, Tanaka S. Critical role of protein kinase C betaII in activation of mast cells by monomeric IgE. J Biol Chem. 2005 Nov 25; 280(47):38976-81. PMID: 16183638.
    Citations: 3     Fields:    Translation:AnimalsCells
  47. Takasaki I, Nojima H, Shiraki K, Sugimoto Y, Ichikawa A, Ushikubi F, Narumiya S, Kuraishi Y. Involvement of cyclooxygenase-2 and EP3 prostaglandin receptor in acute herpetic but not postherpetic pain in mice. Neuropharmacology. 2005 Sep; 49(3):283-92. PMID: 15925391.
    Citations: 3     Fields:    Translation:AnimalsCells
  48. Sugimoto Y, Fukada Y, Mori D, Tanaka S, Yamane H, Okuno Y, Deai K, Tsuchiya S, Tsujimoto G, Ichikawa A. Prostaglandin E2 stimulates granulocyte colony-stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils. J Immunol. 2005 Aug 15; 175(4):2606-12. PMID: 16081835.
    Citations: 8     Fields:    Translation:AnimalsCells
  49. Shoji Y, Takahashi M, Takasuka N, Niho N, Kitamura T, Sato H, Maruyama T, Sugimoto Y, Narumiya S, Sugimura T, Wakabayashi K. Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis. Carcinogenesis. 2005 Dec; 26(12):2116-22. PMID: 16051640.
    Citations: 13     Fields:    Translation:Animals
  50. Kunikata T, Yamane H, Segi E, Matsuoka T, Sugimoto Y, Tanaka S, Tanaka H, Nagai H, Ichikawa A, Narumiya S. Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nat Immunol. 2005 May; 6(5):524-31. PMID: 15806106.
    Citations: 63     Fields:    Translation:Animals
  51. Tanaka S, Mikura S, Hashimoto E, Sugimoto Y, Ichikawa A. Ca2+ influx-mediated histamine synthesis and IL-6 release in mast cells activated by monomeric IgE. Eur J Immunol. 2005 Feb; 35(2):460-8. PMID: 15668925.
    Citations: 12     Fields:    Translation:AnimalsCells
  52. Moriyama T, Higashi T, Togashi K, Iida T, Segi E, Sugimoto Y, Tominaga T, Narumiya S, Tominaga M. Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain. 2005 Jan 17; 1:3. PMID: 15813989.
    Citations: 152     Fields:    Translation:HumansAnimalsCells
  53. Sugimoto Y, Tsuboi H, Okuno Y, Tamba S, Tsuchiya S, Tsujimoto G, Ichikawa A. Microarray evaluation of EP4 receptor-mediated prostaglandin E2 suppression of 3T3-L1 adipocyte differentiation. Biochem Biophys Res Commun. 2004 Sep 24; 322(3):911-7. PMID: 15336550.
    Citations: 12     Fields:    Translation:AnimalsCells
  54. Tsuboi H, Sugimoto Y, Kainoh T, Ichikawa A. Prostanoid EP4 receptor is involved in suppression of 3T3-L1 adipocyte differentiation. Biochem Biophys Res Commun. 2004 Sep 24; 322(3):1066-72. PMID: 15336573.
    Citations: 24     Fields:    Translation:AnimalsCells
  55. Tanaka S, Deai K, Konomi A, Takahashi K, Yamane H, Sugimoto Y, Ichikawa A. Expression of L-histidine decarboxylase in granules of elicited mouse polymorphonuclear leukocytes. Eur J Immunol. 2004 May; 34(5):1472-82. PMID: 15114681.
    Citations: 9     Fields:    Translation:AnimalsCells
  56. Sugimoto Y, Nakato T, Kita A, Takahashi Y, Hatae N, Tabata H, Tanaka S, Ichikawa A. A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors. J Biol Chem. 2004 Mar 19; 279(12):11016-26. PMID: 14699136.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  57. Sugimoto Y, Nakato T, Kita A, Hatae N, Tabata H, Tanaka S, Ichikawa A. Functional domains essential for Gs activity in prostaglandin EP2 and EP3 receptors. Life Sci. 2003 Dec 05; 74(2-3):135-41. PMID: 14607240.
    Citations: 3     Fields:    Translation:AnimalsCells
  58. Tsuchiya S, Tanaka S, Sugimoto Y, Katsuyama M, Ikegami R, Ichikawa A. Identification and characterization of a novel progesterone receptor-binding element in the mouse prostaglandin E receptor subtype EP2 gene. Genes Cells. 2003 Sep; 8(9):747-58. PMID: 12940822.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  59. Oka T, Oka K, Kobayashi T, Sugimoto Y, Ichikawa A, Ushikubi F, Narumiya S, Saper CB. Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors. J Physiol. 2003 Sep 15; 551(Pt 3):945-54. PMID: 12837930.
    Citations: 47     Fields:    Translation:Animals
  60. Minami T, Matsumura S, Mabuchi T, Kobayashi T, Sugimoto Y, Ushikubi F, Ichikawa A, Narumiya S, Ito S. Functional evidence for interaction between prostaglandin EP3 and kappa-opioid receptor pathways in tactile pain induced by human immunodeficiency virus type-1 (HIV-1) glycoprotein gp120. Neuropharmacology. 2003 Jul; 45(1):96-105. PMID: 12814662.
    Citations: 10     Fields:    Translation:AnimalsCells
  61. Shoda J, Ueda T, Kawamoto T, Todoroki T, Asano T, Sugimoto Y, Ichikawa A, Maruyama T, Nimura Y, Tanaka N. Prostaglandin E receptors in bile ducts of hepatolithiasis patients and the pathobiological significance for cholangitis. Clin Gastroenterol Hepatol. 2003 Jul; 1(4):285-96. PMID: 15017670.
    Citations: 3     Fields:    Translation:HumansCells
  62. Hatae N, Kita A, Tanaka S, Sugimoto Y, Ichikawa A. Induction of adherent activity in mastocytoma P-815 cells by the cooperation of two prostaglandin E2 receptor subtypes, EP3 and EP4. J Biol Chem. 2003 May 16; 278(20):17977-81. PMID: 12637575.
    Citations: 2     Fields:    Translation:AnimalsCells
  63. Saito O, Guan Y, Qi Z, Davis LS, Kömhoff M, Sugimoto Y, Narumiya S, Breyer RM, Breyer MD. Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract. Am J Physiol Renal Physiol. 2003 Jun; 284(6):F1164-70. PMID: 12631554.
    Citations: 14     Fields:    Translation:Animals
  64. Tsuboi K, Iwane A, Nakazawa S, Sugimoto Y, Ichikawa A. Role of prostaglandin H2 synthase 2 in murine parturition: study on ovariectomy-induced parturition in prostaglandin F receptor-deficient mice. Biol Reprod. 2003 Jul; 69(1):195-201. PMID: 12620936.
    Citations: 11     Fields:    Translation:Animals
  65. Segi E, Haraguchi K, Sugimoto Y, Tsuji M, Tsunekawa H, Tamba S, Tsuboi K, Tanaka S, Ichikawa A. Expression of messenger RNA for prostaglandin E receptor subtypes EP4/EP2 and cyclooxygenase isozymes in mouse periovulatory follicles and oviducts during superovulation. Biol Reprod. 2003 Mar; 68(3):804-11. PMID: 12604629.
    Citations: 20     Fields:    Translation:Animals
  66. Amano H, Hayashi I, Endo H, Kitasato H, Yamashina S, Maruyama T, Kobayashi M, Satoh K, Narita M, Sugimoto Y, Murata T, Yoshimura H, Narumiya S, Majima M. Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med. 2003 Jan 20; 197(2):221-32. PMID: 12538661.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  67. Mu J, Kanzaki T, Si X, Tomimatsu T, Fukuda H, Shioji M, Murata Y, Sugimoto Y, Ichikawa A. Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice. Biol Reprod. 2003 Jun; 68(6):1968-74. PMID: 12606450.
    Citations: 6     Fields:    Translation:AnimalsCells
  68. Tabata H, Tanaka S, Sugimoto Y, Kanki H, Kaneko S, Ichikawa A. Possible coupling of prostaglandin E receptor EP(1) to TRP5 expressed in Xenopus laevis oocytes. Biochem Biophys Res Commun. 2002 Nov 01; 298(3):398-402. PMID: 12413954.
    Citations: 17     Fields:    Translation:AnimalsCells
  69. Tsuboi K, Sugimoto Y, Ichikawa A. Prostanoid receptor subtypes. Prostaglandins Other Lipid Mediat. 2002 Aug; 68-69:535-56. PMID: 12432942.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  70. Hatae N, Sugimoto Y, Ichikawa A. Prostaglandin receptors: advances in the study of EP3 receptor signaling. J Biochem. 2002 Jun; 131(6):781-4. PMID: 12038972.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  71. Mu J, Kanzaki T, Si X, Tomimatsu T, Fukuda H, Fujii E, Hosono T, Murata Y, Sugimoto Y, Ichikawa A. Apoptosis and related proteins during parturition in prostaglandin F receptor-deficient mice. Biochem Biophys Res Commun. 2002 Apr 05; 292(3):675-81. PMID: 11922619.
    Citations: 2     Fields:    Translation:HumansAnimals
  72. Asano T, Shoda J, Ueda T, Kawamoto T, Todoroki T, Shimonishi M, Tanabe T, Sugimoto Y, Ichikawa A, Mutoh M, Tanaka N, Miwa M. Expressions of cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression. Clin Cancer Res. 2002 Apr; 8(4):1157-67. PMID: 11948128.
    Citations: 23     Fields:    Translation:HumansCells
  73. Kabashima K, Saji T, Murata T, Nagamachi M, Matsuoka T, Segi E, Tsuboi K, Sugimoto Y, Kobayashi T, Miyachi Y, Ichikawa A, Narumiya S. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest. 2002 Apr; 109(7):883-93. PMID: 11927615.
    Citations: 148     Fields:    Translation:AnimalsCells
  74. Yoshida K, Oida H, Kobayashi T, Maruyama T, Tanaka M, Katayama T, Yamaguchi K, Segi E, Tsuboyama T, Matsushita M, Ito K, Ito Y, Sugimoto Y, Ushikubi F, Ohuchida S, Kondo K, Nakamura T, Narumiya S. Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4580-5. PMID: 11917107.
    Citations: 67     Fields:    Translation:AnimalsCells
  75. Fennekohl A, Sugimoto Y, Segi E, Maruyama T, Ichikawa A, Püschel GP. Contribution of the two Gs-coupled PGE2-receptors EP2-receptor and EP4-receptor to the inhibition by PGE2 of the LPS-induced TNFalpha-formation in Kupffer cells from EP2-or EP4-receptor-deficient mice. Pivotal role for the EP4-receptor in wild type Kupffer cells. J Hepatol. 2002 Mar; 36(3):328-34. PMID: 11867175.
    Citations: 15     Fields:    Translation:AnimalsCells
  76. Safina F, Tanaka S, Inagaki M, Tsuboi K, Sugimoto Y, Ichikawa A. Expression of L-histidine decarboxylase in mouse male germ cells. J Biol Chem. 2002 Apr 19; 277(16):14211-5. PMID: 11827977.
    Citations: 5     Fields:    Translation:AnimalsCells
  77. Torii E, Segi E, Sugimoto Y, Takahashi K, Kabashima K, Ikai K, Ichikawa A. Expression of prostaglandin E(2) receptor subtypes in mouse hair follicles. Biochem Biophys Res Commun. 2002 Jan 18; 290(2):696-700. PMID: 11785955.
    Citations: 6     Fields:    Translation:Animals
  78. Hatae N, Yamaoka K, Sugimoto Y, Negishi M, Ichikawa A. Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbetagamma subunit-independent manner. Biochem Biophys Res Commun. 2002 Jan 11; 290(1):162-8. PMID: 11779148.
    Citations: 9     Fields:    Translation:AnimalsCells
  79. Mutoh M, Watanabe K, Kitamura T, Shoji Y, Takahashi M, Kawamori T, Tani K, Kobayashi M, Maruyama T, Kobayashi K, Ohuchida S, Sugimoto Y, Narumiya S, Sugimura T, Wakabayashi K. Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. Cancer Res. 2002 Jan 01; 62(1):28-32. PMID: 11782353.
    Citations: 98     Fields:    Translation:Animals
  80. Tsuboi K, Sugimoto Y, Iwane A, Yamamoto K, Yamamoto S, Ichikawa A. Uterine Expression of Prostaglandin H2 Synthase in Late Pregnancy and during Parturition in Prostaglandin F Receptor-Deficient Mice1. Endocrinology. 2000 Jan 01; 141(1):315-324. PMID: 28200877.
    Citations:    Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.