Harvard Catalyst Profiles

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Jacqueline Shirley Dron, Ph.D.

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Western University, London, CanadaPhD12/2020Biochemistry
Western University, London, CanadaBSc06/2015Genetics

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. Banting Postdoctoral Fellowship (DRON, SHIRLEY JACQUELINE)
    Leveraging genomic, metabolomic, and proteomic data to identify clinically-relevant subtypes and new pathways driving risk of coronary artery disease
  2. BioData Catalyst Fellowship (DRON, SHIRLEY JACQUELINE)
    Modeling lifetime coronary artery disease trajectories of naturally occurring DNA variation linked to low circulating triglycerides

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Brockman DG, Petronio L, Dron JS, Kwon BC, Vosburg T, Nip L, Tang A, O'Reilly M, Lennon N, Wong B, Ng K, Huang KH, Fahed AC, Khera AV. Design and user experience testing of a polygenic score report: a qualitative study of prospective users. BMC Med Genomics. 2021 10 01; 14(1):238. PMID: 34598685.
    Citations: 2     Fields:    Translation:Humans
  2. Dron JS, Hegele RA. Editorial: Discussing polygenic risk with lipid clinic patients. Curr Opin Lipidol. 2021 08 01; 32(4):273-275. PMID: 34054107.
    Citations:    Fields:    Translation:Humans
  3. Lazarte J, Laksman ZW, Wang J, Robinson JF, Dron JS, Leach E, Liew J, McIntyre AD, Skanes AC, Gula LJ, Leong-Sit P, Cao H, Trost B, Scherer SW, Hegele RA, Roberts JD. Enrichment of loss-of-function and copy number variants in ventricular cardiomyopathy genes in 'lone' atrial fibrillation. Europace. 2021 06 07; 23(6):844-850. PMID: 33682005.
    Citations:    Fields:    Translation:Humans
  4. Gill PK, Dron JS, Hegele RA. Genetics of hypertriglyceridemia and atherosclerosis. Curr Opin Cardiol. 2021 05 01; 36(3):264-271. PMID: 33818545.
    Citations: 4     Fields:    Translation:Humans
  5. Wand H, Lambert SA, Tamburro C, Iacocca MA, O'Sullivan JW, Sillari C, Kullo IJ, Rowley R, Dron JS, Brockman D, Venner E, McCarthy MI, Antoniou AC, Easton DF, Hegele RA, Khera AV, Chatterjee N, Kooperberg C, Edwards K, Vlessis K, Kinnear K, Danesh JN, Parkinson H, Ramos EM, Roberts MC, Ormond KE, Khoury MJ, Janssens ACJW, Goddard KAB, Kraft P, MacArthur JAL, Inouye M, Wojcik GL. Improving reporting standards for polygenic scores in risk prediction studies. Nature. 2021 03; 591(7849):211-219. PMID: 33692554.
    Citations: 31     Fields:    Translation:Humans
  6. May SC, Dron JS, Hegele RA, Sahoo D. Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions. J Lipid Res. 2021; 62:100045. PMID: 33577783.
    Citations: 2     Fields:    Translation:Animals
  7. Lazarte J, Dron JS, McIntyre AD, Skanes AC, Gula LJ, Tang AS, Tadros R, Laksman ZW, Hegele RA, Roberts JD. Evaluating Polygenic Risk Scores in "Lone" Atrial Fibrillation. CJC Open. 2021 Jun; 3(6):751-757. PMID: 34169254.
  8. Lazarte J, Dron JS, McIntyre AD, Skanes AC, Gula LJ, Tang AS, Tadros R, Laksman ZW, Hegele RA, Roberts JD. Role of Common Genetic Variation in Lone Atrial Fibrillation. Circ Genom Precis Med. 2021 02; 14(1):e003179. PMID: 33517663.
    Citations: 1     Fields:    Translation:Humans
  9. Dron JS, Wang M, Patel AP, Kartoun U, Ng K, Hegele RA, Khera AV. Genetic Predictor to Identify Individuals With High Lipoprotein(a) Concentrations. Circ Genom Precis Med. 2021 02; 14(1):e003182. PMID: 33522245.
    Citations:    Fields:    Translation:Humans
  10. Gill PK, Dron JS, Dilliott AA, McIntyre AD, Cao H, Wang J, Movsesyan IG, Malloy MJ, Pullinger CR, Kane JP, Hegele RA. Ancestry-specific profiles of genetic determinants of severe hypertriglyceridemia. J Clin Lipidol. 2021 Jan-Feb; 15(1):88-96. PMID: 33303403.
    Citations: 1     Fields:    Translation:Humans
  11. Gill PK, Dron JS, Berberich AJ, Wang J, McIntyre AD, Cao H, Hegele RA. Combined hyperlipidemia is genetically similar to isolated hypertriglyceridemia. J Clin Lipidol. 2021 Jan-Feb; 15(1):79-87. PMID: 33303402.
    Citations:    Fields:    Translation:Humans
  12. Hegele RA, Dron JS. 2019 George Lyman Duff Memorial Lecture: Three Decades of Examining DNA in Patients With Dyslipidemia. Arterioscler Thromb Vasc Biol. 2020 09; 40(9):1970-1981. PMID: 32762461.
    Citations: 1     Fields:    Translation:Humans
  13. Dron JS, Hegele RA. Genetics of Hypertriglyceridemia. Front Endocrinol (Lausanne). 2020; 11:455. PMID: 32793115.
    Citations: 15     Fields:    Translation:Humans
  14. Dron JS, Dilliott AA, Lawson A, McIntyre AD, Davis BD, Wang J, Cao H, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA. Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia. Arterioscler Thromb Vasc Biol. 2020 08; 40(8):1935-1941. PMID: 32580631.
    Citations: 5     Fields:    Translation:Humans
  15. Dron JS, Wang J, McIntyre AD, Iacocca MA, Robinson JF, Ban MR, Cao H, Hegele RA. Six years' experience with LipidSeq: clinical and research learnings from a hybrid, targeted sequencing panel for dyslipidemias. BMC Med Genomics. 2020 02 10; 13(1):23. PMID: 32041611.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  16. Dron JS, Wang J, McIntyre AD, Cao H, Hegele RA. The polygenic nature of mild-to-moderate hypertriglyceridemia. J Clin Lipidol. 2020 Jan - Feb; 14(1):28-34.e2. PMID: 32033914.
    Citations: 4     Fields:    Translation:Humans
  17. Dron JS, Hegele RA. A tip of the CAP1 to cholesterol metabolism. Eur Heart J. 2020 01 07; 41(2):253-254. PMID: 31665282.
    Citations: 1     Fields:    
  18. Dron JS, Hegele RA. Ischemic Event Reduction and Triglycerides. J Am Coll Cardiol. 2019 10 08; 74(14):1848-1849. PMID: 31582149.
    Citations:    Fields:    Translation:Humans
  19. Dron JS, Wang J, McIntyre AD, Cao H, Robinson JF, Duell PB, Manjoo P, Feng J, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA. Partial LPL deletions: rare copy-number variants contributing towards severe hypertriglyceridemia. J Lipid Res. 2019 11; 60(11):1953-1958. PMID: 31519763.
    Citations: 2     Fields:    Translation:Humans
  20. Berg MD, Giguere DJ, Dron JS, Lant JT, Genereaux J, Liao C, Wang J, Robinson JF, Gloor GB, Hegele RA, O'Donoghue P, Brandl CJ. Targeted sequencing reveals expanded genetic diversity of human transfer RNAs. RNA Biol. 2019 11; 16(11):1574-1585. PMID: 31407949.
    Citations: 4     Fields:    Translation:HumansCells
  21. Gulilat M, Lamb T, Teft WA, Wang J, Dron JS, Robinson JF, Tirona RG, Hegele RA, Kim RB, Schwarz UI. Targeted next generation sequencing as a tool for precision medicine. BMC Med Genomics. 2019 06 03; 12(1):81. PMID: 31159795.
    Citations: 13     Fields:    Translation:Humans
  22. Dron JS, Hegele RA. The evolution of genetic-based risk scores for lipids and cardiovascular disease. Curr Opin Lipidol. 2019 04; 30(2):71-81. PMID: 30676533.
    Citations: 12     Fields:    Translation:Humans
  23. Iacocca MA, Dron JS, Hegele RA. Progress in finding pathogenic DNA copy number variations in dyslipidemia. Curr Opin Lipidol. 2019 04; 30(2):63-70. PMID: 30664016.
    Citations: 2     Fields:    Translation:Humans
  24. Dron JS, Lazarte J, Hegele RA. Recent Highlights of ATVB. Arterioscler Thromb Vasc Biol. 2018 11; 38(11):e185-e197. PMID: 30354244.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  25. Dron JS, Wang J, Cao H, McIntyre AD, Iacocca MA, Menard JR, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA. Severe hypertriglyceridemia is primarily polygenic. J Clin Lipidol. 2019 Jan - Feb; 13(1):80-88. PMID: 30466821.
    Citations: 29     Fields:    Translation:Humans
  26. Iacocca MA, Wang J, Sarkar S, Dron JS, Lagace T, McIntyre AD, Lau P, Robinson JF, Yang P, Knoll JH, Cao H, McPherson R, Hegele RA. Whole-Gene Duplication of PCSK9 as a Novel Genetic Mechanism for Severe Familial Hypercholesterolemia. Can J Cardiol. 2018 10; 34(10):1316-1324. PMID: 30269829.
    Citations: 7     Fields:    Translation:Humans
  27. Dron JS, Wang J, Berberich AJ, Iacocca MA, Cao H, Yang P, Knoll J, Tremblay K, Brisson D, Netzer C, Gouni-Berthold I, Gaudet D, Hegele RA. Large-scale deletions of the ABCA1 gene in patients with hypoalphalipoproteinemia. J Lipid Res. 2018 08; 59(8):1529-1535. PMID: 29866657.
    Citations: 6     Fields:    Translation:Humans
  28. Dron JS, Hegele RA. Polygenic influences on dyslipidemias. Curr Opin Lipidol. 2018 04; 29(2):133-143. PMID: 29300201.
    Citations: 16     Fields:    Translation:Humans
  29. Dron JS, Ho R, Hegele RA. Recent Advances in the Genetics of Atherothrombotic Disease and Its Determinants. Arterioscler Thromb Vasc Biol. 2017 10; 37(10):e158-e166. PMID: 28954809.
    Citations: 2     Fields:    Translation:HumansAnimals
  30. Iacocca MA, Wang J, Dron JS, Robinson JF, McIntyre AD, Cao H, Hegele RA. Use of next-generation sequencing to detect LDLR gene copy number variation in familial hypercholesterolemia. J Lipid Res. 2017 11; 58(11):2202-2209. PMID: 28874442.
    Citations: 12     Fields:    Translation:Humans
  31. Dron JS, Wang J, Low-Kam C, Khetarpal SA, Robinson JF, McIntyre AD, Ban MR, Cao H, Rhainds D, Dubé MP, Rader DJ, Lettre G, Tardif JC, Hegele RA. Polygenic determinants in extremes of high-density lipoprotein cholesterol. J Lipid Res. 2017 11; 58(11):2162-2170. PMID: 28870971.
    Citations: 15     Fields:    Translation:Humans
  32. Dron JS, Hegele RA. Genetics of Triglycerides and the Risk of Atherosclerosis. Curr Atheroscler Rep. 2017 Jul; 19(7):31. PMID: 28534127.
    Citations: 31     Fields:    Translation:Humans
  33. Dron JS, Hegele RA. Complexity of mechanisms among human proprotein convertase subtilisin-kexin type 9 variants. Curr Opin Lipidol. 2017 Apr; 28(2):161-169. PMID: 28157721.
    Citations: 13     Fields:    Translation:HumansAnimals
  34. Wang J, Dron JS, Ban MR, Robinson JF, McIntyre AD, Alazzam M, Zhao PJ, Dilliott AA, Cao H, Huff MW, Rhainds D, Low-Kam C, Dubé MP, Lettre G, Tardif JC, Hegele RA. Polygenic Versus Monogenic Causes of Hypercholesterolemia Ascertained Clinically. Arterioscler Thromb Vasc Biol. 2016 12; 36(12):2439-2445. PMID: 27765764.
    Citations: 46     Fields:    Translation:Humans
  35. Burke AC, Dron JS, Hegele RA, Huff MW. PCSK9: Regulation and Target for Drug Development for Dyslipidemia. Annu Rev Pharmacol Toxicol. 2017 01 06; 57:223-244. PMID: 27575716.
    Citations: 15     Fields:    Translation:HumansAnimals
  36. Dron JS, Hegele RA. Genetics of Lipid and Lipoprotein Disorders and Traits. Curr Genet Med Rep. 2016; 4(3):130-141. PMID: 28286704.
    Citations: 24     
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.