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Siva Sathyanarayana Murthy Uppu Divakara, Ph.D.


Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, IndiaPh.D.05/2016Chemical Biology
Singapore-MIT Alliance for Research and Technology, Singapore10/2018Infectious Diseases & Antimicrobial Resistance
Massachusetts Institute of Technology, Cambridge, Massachusetts04/2018Chemical Engineering
Institute of Basic Science, South Korea03/2020Nanomedicine


Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Uppu DS, Min Y, Kim I, Kumar S, Park J, Cho YK. Glycolipid-Anchored Proteins on Bioengineered Extracellular Vesicles for Lipopolysaccharide Neutralization. ACS Appl Mater Interfaces. 2021 Jun 30; 13(25):29313-29324. PMID: 34137258.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Uppu DSSM, Turvey ME, Sharif ARM, Bidet K, He Y, Ho V, Tambe AD, Lescar J, Tan EY, Fink K, Chen J, Hammond PT. Temporal release of a three-component protein subunit vaccine from polymer multilayers. J Control Release. 2020 01 10; 317:130-141. PMID: 31756392.
    Citations: 9     Fields:    Translation:AnimalsPHPublic Health
  3. Turvey ME, Uppu DSSM, Mohamed Sharif AR, Bidet K, Alonso S, Ooi EE, Hammond PT. Microneedle-based intradermal delivery of stabilized dengue virus. Bioeng Transl Med. 2019 May; 4(2):e10127. PMID: 31249877; PMCID: PMC6584444.
    Citations: 9     
  4. He Y, Hong C, Li J, Howard MT, Li Y, Turvey ME, Uppu DSSM, Martin JR, Zhang K, Irvine DJ, Hammond PT. Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination. ACS Nano. 2018 10 23; 12(10):10272-10280. PMID: 30272942; PMCID: PMC6501205.
    Citations: 10     Fields:    Translation:HumansAnimalsPHPublic Health
  5. Uppu DSSM, Konai MM, Sarkar P, Samaddar S, Fensterseifer ICM, Farias-Junior C, Krishnamoorthy P, Shome BR, Franco OL, Haldar J. Membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards Gram-negative bacteria. PLoS One. 2017; 12(8):e0183263. PMID: 28837596.
    Citations: 13     Fields:    Translation:AnimalsCells
  6. Ghosh C, Sarkar P, Samaddar S, Uppu DSSM, Haldar J. l-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria. Chem Commun (Camb). 2017 Jul 25; 53(60):8427-8430. PMID: 28702588.
    Citations: 4     Fields:    Translation:Cells
  7. Hoque J, Akkapeddi P, Ghosh C, Uppu DS, Haldar J. A Biodegradable Polycationic Paint that Kills Bacteria in Vitro and in Vivo. ACS Appl Mater Interfaces. 2016 Nov 02; 8(43):29298-29309. PMID: 27709890.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  8. Uppu DS, Samaddar S, Hoque J, Konai MM, Krishnamoorthy P, Shome BR, Haldar J. Side Chain Degradable Cationic-Amphiphilic Polymers with Tunable Hydrophobicity Show in Vivo Activity. Biomacromolecules. 2016 09 12; 17(9):3094-102. PMID: 27442617.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  9. Uppu DSSM, Konai MM, Baul U, Singh P, Siersma TK, Samaddar S, Vemparala S, Hamoen LW, Narayana C, Haldar J. Isosteric substitution in cationic-amphiphilic polymers reveals an important role for hydrogen bonding in bacterial membrane interactions. Chem Sci. 2016 Jul 01; 7(7):4613-4623. PMID: 30155109; PMCID: PMC6016443.
    Citations: 7     
  10. Uppu DS, Bhowmik M, Samaddar S, Haldar J. Cyclization and unsaturation rather than isomerisation of side chains govern the selective antibacterial activity of cationic-amphiphilic polymers. Chem Commun (Camb). 2016 Mar 28; 52(25):4644-7. PMID: 26947459.
    Citations: 7     Fields:    
  11. Uppu DS, Haldar J. Lipopolysaccharide Neutralization by Cationic-Amphiphilic Polymers through Pseudoaggregate Formation. Biomacromolecules. 2016 Mar 14; 17(3):862-73. PMID: 26839947.
    Citations: 15     Fields:    Translation:HumansCells
  12. Ghosh C, Manjunath GB, Konai MM, Uppu DS, Hoque J, Paramanandham K, Shome BR, Haldar J. Aryl-Alkyl-Lysines: Agents That Kill Planktonic Cells, Persister Cells, Biofilms of MRSA and Protect Mice from Skin-Infection. PLoS One. 2015; 10(12):e0144094. PMID: 26669634.
    Citations: 12     Fields:    Translation:AnimalsCells
  13. Ghosh C, Manjunath GB, Konai MM, Uppu DS, Paramanandham K, Shome BR, Ravikumar R, Haldar J. Aryl-alkyl-lysines: Membrane-Active Small Molecules Active against Murine Model of Burn Infection. ACS Infect Dis. 2016 02 12; 2(2):111-22. PMID: 27624962.
    Citations: 5     Fields:    Translation:AnimalsCells
  14. Uppu DS, Samaddar S, Ghosh C, Paramanandham K, Shome BR, Haldar J. Amide side chain amphiphilic polymers disrupt surface established bacterial bio-films and protect mice from chronic Acinetobacter baumannii infection. Biomaterials. 2016 Jan; 74:131-43. PMID: 26454051.
    Citations: 14     Fields:    Translation:AnimalsCells
  15. Uppu DS, Manjunath GB, Yarlagadda V, Kaviyil JE, Ravikumar R, Paramanandham K, Shome BR, Haldar J. Correction: Membrane-active macromolecules resensitize NDM-1 gram-negative clinical isolates to tetracycline antibiotics. PLoS One. 2015; 10(4):e0126757. PMID: 25879927; PMCID: PMC4400169.
    Citations:    Fields:    Translation:HumansAnimalsCells
  16. Uppu DS, Manjunath GB, Yarlagadda V, Kaviyil JE, Ravikumar R, Paramanandham K, Shome BR, Haldar J. Membrane-active macromolecules resensitize NDM-1 gram-negative clinical isolates to tetracycline antibiotics. PLoS One. 2015; 10(3):e0119422. PMID: 25789871.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  17. Uppu DS, Ghosh C, Haldar J. Surviving sepsis in the era of antibiotic resistance: are there any alternative approaches to antibiotic therapy? Microb Pathog. 2015 Mar; 80:7-13. PMID: 25677832.
    Citations: 10     Fields:    Translation:Humans
  18. Hoque J, Akkapeddi P, Yadav V, Manjunath GB, Uppu DS, Konai MM, Yarlagadda V, Sanyal K, Haldar J. Broad spectrum antibacterial and antifungal polymeric paint materials: synthesis, structure-activity relationship, and membrane-active mode of action. ACS Appl Mater Interfaces. 2015 Jan 28; 7(3):1804-15. PMID: 25541751.
    Citations: 19     Fields:    Translation:HumansCells
  19. Ghosh C, Manjunath GB, Akkapeddi P, Yarlagadda V, Hoque J, Uppu DS, Konai MM, Haldar J. Small molecular antibacterial peptoid mimics: the simpler the better! J Med Chem. 2014 Feb 27; 57(4):1428-36. PMID: 24479371.
    Citations: 41     Fields:    Translation:Cells
  20. Uppu DS, Akkapeddi P, Manjunath GB, Yarlagadda V, Hoque J, Haldar J. Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents. Chem Commun (Camb). 2013 Oct 21; 49(82):9389-91. PMID: 23868724.
    Citations: 17     Fields:    Translation:HumansCells
  21. Hoque J, Akkapeddi P, Yarlagadda V, Uppu DS, Kumar P, Haldar J. Cleavable cationic antibacterial amphiphiles: synthesis, mechanism of action, and cytotoxicities. Langmuir. 2012 Aug 21; 28(33):12225-34. PMID: 22838496.
    Citations: 19     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.