Harvard Catalyst Profiles

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Sean Davies, M.B.,B.S.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tao H, Huang J, Yancey PG, Yermalitsky V, Blakemore JL, Zhang Y, Ding L, Zagol-Ikapitte I, Ye F, Amarnath V, Boutaud O, Oates JA, Roberts LJ, Davies SS, Linton MF. Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr-/- mice. Nat Commun. 2020 08 14; 11(1):4084. PMID: 32796843.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  2. Beavers WN, Monteith AJ, Amarnath V, Mernaugh RL, Roberts LJ, Chazin WJ, Davies SS, Skaar EP. Arachidonic Acid Kills Staphylococcus aureus through a Lipid Peroxidation Mechanism. mBio. 2019 10 01; 10(5). PMID: 31575763; PMCID: PMC6775451.
    Citations: 14     Fields:    Translation:AnimalsCells
  3. Yermalitsky VN, Matafonova E, Tallman K, Li Z, Zackert W, Roberts LJ, Amarnath V, Davies SS. Simplified LC/MS assay for the measurement of isolevuglandin protein adducts in plasma and tissue samples. Anal Biochem. 2019 02 01; 566:89-101. PMID: 30458125.
    Citations: 5     Fields:    Translation:AnimalsCells
  4. May-Zhang LS, Yermalitsky V, Huang J, Pleasent T, Borja MS, Oda MN, Jerome WG, Yancey PG, Linton MF, Davies SS. Modification by isolevuglandins, highly reactive ?-ketoaldehydes, deleteriously alters high-density lipoprotein structure and function. J Biol Chem. 2018 06 15; 293(24):9176-9187. PMID: 29712723.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  5. Longato L, Andreola F, Davies SS, Roberts JL, Fusai G, Pinzani M, Moore K, Rombouts K. Reactive gamma-ketoaldehydes as novel activators of hepatic stellate cells in vitro. Free Radic Biol Med. 2017 01; 102:162-173. PMID: 27890721.
    Citations: 3     Fields:    Translation:HumansCells
  6. Ormseth MJ, Yancey PG, Solus JF, Bridges SL, Curtis JR, Linton MF, Fazio S, Davies SS, Roberts LJ, Vickers KC, Kon V, Michael Stein C. Effect of Drug Therapy on Net Cholesterol Efflux Capacity of High-Density Lipoprotein-Enriched Serum in Rheumatoid Arthritis. Arthritis Rheumatol. 2016 09; 68(9):2099-105. PMID: 26991245; PMCID: PMC5001900.
    Citations: 18     Fields:    Translation:Humans
  7. Ormseth MJ, Yancey PG, Yamamoto S, Oeser AM, Gebretsadik T, Shintani A, Linton MF, Fazio S, Davies SS, Roberts LJ, Vickers KC, Raggi P, Kon V, Stein CM. Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis. IJC Metab Endocr. 2016 Dec; 13:6-11. PMID: 28243578; PMCID: PMC5325720.
    Citations: 6     
  8. Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ, Madhur MS, Harrison DG. Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest. 2016 Apr 01; 126(4):1607. PMID: 27035819; PMCID: PMC4811163.
    Citations: 18     Fields:    
  9. Bomar L, Brugger SD, Yost BH, Davies SS, Lemon KP. Corynebacterium accolens Releases Antipneumococcal Free Fatty Acids from Human Nostril and Skin Surface Triacylglycerols. mBio. 2016 Jan 05; 7(1):e01725-15. PMID: 26733066.
    Citations: 101     Fields:    Translation:HumansCells
  10. Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ, Madhur MS, Harrison DG. Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest. 2016 Jan; 126(1):50-67. PMID: 26595812; PMCID: PMC4701546.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  11. Sidorova TN, Yermalitskaya LV, Mace LC, Wells KS, Boutaud O, Prinsen JK, Davies SS, Roberts LJ, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT. Reactive ?-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells. J Mol Cell Cardiol. 2015 Feb; 79:295-302. PMID: 25463275; PMCID: PMC4302000.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  12. Guo L, Chen Z, Amarnath V, Davies SS. Identification of novel bioactive aldehyde-modified phosphatidylethanolamines formed by lipid peroxidation. Free Radic Biol Med. 2012 Sep 15; 53(6):1226-38. PMID: 22898174.
    Citations: 17     Fields:    Translation:HumansCells
  13. Milne GL, Yin H, Hardy KD, Davies SS, Roberts LJ. Isoprostane generation and function. Chem Rev. 2011 Oct 12; 111(10):5973-96. PMID: 21848345.
    Citations: 111     Fields:    Translation:HumansCells
  14. Traustadóttir T, Davies SS, Su Y, Choi L, Brown-Borg HM, Roberts LJ, Harman SM. Oxidative stress in older adults: effects of physical fitness. Age (Dordr). 2012 Aug; 34(4):969-82. PMID: 21671197.
    Citations: 21     Fields:    Translation:HumansCells
  15. Friel JK, Diehl-Jones B, Cockell KA, Chiu A, Rabanni R, Davies SS, Roberts LJ. Evidence of oxidative stress in relation to feeding type during early life in premature infants. Pediatr Res. 2011 Feb; 69(2):160-4. PMID: 21045751.
    Citations: 16     Fields:    Translation:HumansCells
  16. Davies SS, Bodine C, Matafonova E, Pantazides BG, Bernoud-Hubac N, Harrison FE, Olson SJ, Montine TJ, Amarnath V, Roberts LJ. Treatment with a ?-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice. J Alzheimers Dis. 2011; 27(1):49-59. PMID: 21709376.
    Citations: 26     Fields:    Translation:HumansAnimals
  17. Davies SS, Roberts LJ. F2-isoprostanes as an indicator and risk factor for coronary heart disease. Free Radic Biol Med. 2011 Mar 01; 50(5):559-66. PMID: 21126576.
    Citations: 49     Fields:    Translation:HumansCells
  18. Stavrovskaya IG, Baranov SV, Guo X, Davies SS, Roberts LJ, Kristal BS. Reactive gamma-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis. Free Radic Biol Med. 2010 Aug 15; 49(4):567-79. PMID: 20472054.
    Citations: 20     Fields:    Translation:AnimalsCells
  19. Zagol-Ikapitte IA, Matafonova E, Amarnath V, Bodine CL, Boutaud O, Tirona RG, Oates JA, Roberts LJ, Davies SS. Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent ?-Ketoaldehyde Scavenger, by LC/MS/MS. Pharmaceutics. 2010 Mar; 2(1):18-29. PMID: 21822464.
    Citations: 19     
  20. Sullivan CB, Matafonova E, Roberts LJ, Amarnath V, Davies SS. Isoketals form cytotoxic phosphatidylethanolamine adducts in cells. J Lipid Res. 2010 May; 51(5):999-1009. PMID: 19965577.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  21. Traustadóttir T, Davies SS, Stock AA, Su Y, Heward CB, Roberts LJ, Harman SM. Tart cherry juice decreases oxidative stress in healthy older men and women. J Nutr. 2009 Oct; 139(10):1896-900. PMID: 19692530.
    Citations: 47     Fields:    Translation:HumansAnimals
  22. Davies SS, Traustadóttir T, Stock AA, Ye F, Shyr Y, Harman SM, Roberts LJ. Ischemia/reperfusion unveils impaired capacity of older adults to restrain oxidative insult. Free Radic Biol Med. 2009 Oct 01; 47(7):1014-8. PMID: 19596063.
    Citations: 9     Fields:    Translation:Humans
  23. Bernoud-Hubac N, Alam DA, Lefils J, Davies SS, Amarnath V, Guichardant M, Roberts LJ, Lagarde M. Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation. Biochim Biophys Acta. 2009 Apr; 1791(4):307-13. PMID: 19233311.
    Citations: 11     Fields:    Translation:HumansCells
  24. Boyden PA, Davies SS, Viswanathan PC, Amarnath V, Balser JR, Roberts LJ. Potential role of isoketals formed via the isoprostane pathway of lipid peroxidation in ischemic arrhythmias. J Cardiovasc Pharmacol. 2007 Nov; 50(5):480-6. PMID: 18030056.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  25. Frisard MI, Broussard A, Davies SS, Roberts LJ, Rood J, de Jonge L, Fang X, Jazwinski SM, Deutsch WA, Ravussin E. Aging, resting metabolic rate, and oxidative damage: results from the Louisiana Healthy Aging Study. J Gerontol A Biol Sci Med Sci. 2007 Jul; 62(7):752-9. PMID: 17634323; PMCID: PMC2692620.
    Citations: 40     Fields:    Translation:Humans
  26. Davies SS, Amarnath V, Brame CJ, Boutaud O, Roberts LJ. Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry. Nat Protoc. 2007; 2(9):2079-91. PMID: 17853863.
    Citations: 21     Fields:    Translation:Cells
  27. Davies SS, Brantley EJ, Voziyan PA, Amarnath V, Zagol-Ikapitte I, Boutaud O, Hudson BG, Oates JA, Roberts LJ. Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity. Biochemistry. 2006 Dec 26; 45(51):15756-67. PMID: 17176098.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  28. Talati M, Meyrick B, Peebles RS, Davies SS, Dworski R, Mernaugh R, Mitchell D, Boothby M, Roberts LJ, Sheller JR. Oxidant stress modulates murine allergic airway responses. Free Radic Biol Med. 2006 Apr 01; 40(7):1210-9. PMID: 16545689.
    Citations: 21     Fields:    Translation:AnimalsCells
  29. Fukuda K, Davies SS, Nakajima T, Ong BH, Kupershmidt S, Fessel J, Amarnath V, Anderson ME, Boyden PA, Viswanathan PC, Roberts LJ, Balser JR. Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels. Circ Res. 2005 Dec 09; 97(12):1262-9. PMID: 16284182.
    Citations: 65     Fields:    Translation:HumansCells
  30. Davies SS, Zackert W, Luo Y, Cunningham CC, Frisard M, Roberts LJ. Quantification of dinor, dihydro metabolites of F2-isoprostanes in urine by liquid chromatography/tandem mass spectrometry. Anal Biochem. 2006 Jan 15; 348(2):185-91. PMID: 16309621.
    Citations: 18     Fields:    Translation:Humans
  31. Roberts LJ, Fessel JP, Davies SS. The biochemistry of the isoprostane, neuroprostane, and isofuran Pathways of lipid peroxidation. Brain Pathol. 2005 Apr; 15(2):143-8. PMID: 15912887.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  32. Bernoud-Hubac N, Fay LB, Armarnath V, Guichardant M, Bacot S, Davies SS, Roberts LJ, Lagarde M. Covalent binding of isoketals to ethanolamine phospholipids. Free Radic Biol Med. 2004 Nov 15; 37(10):1604-11. PMID: 15477011.
    Citations: 21     Fields:    
  33. Davies SS, Talati M, Wang X, Mernaugh RL, Amarnath V, Fessel J, Meyrick BO, Sheller J, Roberts LJ. Localization of isoketal adducts in vivo using a single-chain antibody. Free Radic Biol Med. 2004 May 01; 36(9):1163-74. PMID: 15082070.
    Citations: 32     Fields:    Translation:AnimalsCells
  34. Davies SS, Amarnath V, Roberts LJ. Isoketals: highly reactive gamma-ketoaldehydes formed from the H2-isoprostane pathway. Chem Phys Lipids. 2004 Mar; 128(1-2):85-99. PMID: 15037155.
    Citations: 28     Fields:    
  35. Brame CJ, Boutaud O, Davies SS, Yang T, Oates JA, Roden D, Roberts LJ. Modification of proteins by isoketal-containing oxidized phospholipids. J Biol Chem. 2004 Apr 02; 279(14):13447-51. PMID: 14715668.
    Citations: 36     Fields:    Translation:AnimalsCells
  36. Boutaud O, Li J, Zagol I, Shipp EA, Davies SS, Roberts LJ, Oates JA. Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation. J Biol Chem. 2003 May 09; 278(19):16926-8. PMID: 12637576.
    Citations: 17     Fields:    Translation:HumansCells
  37. Davies SS, Ju WK, Neufeld AH, Abran D, Chemtob S, Roberts LJ. Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro. J Ocul Pharmacol Ther. 2003 Feb; 19(1):45-54. PMID: 12648303.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  38. Davies SS, Amarnath V, Montine KS, Bernoud-Hubac N, Boutaud O, Montine TJ, Roberts LJ. Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function. FASEB J. 2002 May; 16(7):715-7. PMID: 11978738.
    Citations: 36     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.