Harvard Catalyst Profiles

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Nathan W Zammit, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bartonicek N, Rouet R, Warren J, Loetsch C, Rodriguez GS, Walters S, Lin F, Zahra D, Blackburn J, Hammond JM, Reis ALM, Deveson IW, Zammit N, Zeraati M, Grey S, Christ D, Mattick JS, Chtanova T, Brink R, Dinger ME, Weatheritt RJ, Sprent J, King C. The retroelement Lx9 puts a brake on the immune response to virus infection. Nature. 2022 08; 608(7924):757-765. PMID: 35948641.
    Citations:    Fields:    Translation:AnimalsCells
  2. Zammit NW, McDowell J, Warren J, Muskovic W, Gamble J, Shi YC, Kaczorowski D, Chan CL, Powell J, Ormandy C, Brown D, Oakes SR, Grey ST. TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS Inflammation. Front Immunol. 2022; 13:811525. PMID: 35464428; PMCID: PMC9027572.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Zammit NW, Seeberger KL, Zamerli J, Walters SN, Lisowski L, Korbutt GS, Grey ST. Selection of a novel AAV2/TNFAIP3 vector for local suppression of islet xenograft inflammation. Xenotransplantation. 2021 05; 28(3):e12669. PMID: 33316848.
    Citations:    Fields:    Translation:AnimalsCells
  4. Aksoy YA, Yang B, Chen W, Hung T, Kuchel RP, Zammit NW, Grey ST, Goldys EM, Deng W. Spatial and Temporal Control of CRISPR-Cas9-Mediated Gene Editing Delivered via a Light-Triggered Liposome System. ACS Appl Mater Interfaces. 2020 Nov 25; 12(47):52433-52444. PMID: 33174413.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  5. Cultrone D, Zammit NW, Self E, Postert B, Han JZR, Bailey J, Warren J, Croucher DR, Kikuchi K, Bogdanovic O, Chtanova T, Hesselson D, Grey ST. A zebrafish functional genomics model to investigate the role of human A20 variants in vivo. Sci Rep. 2020 11 05; 10(1):19085. PMID: 33154446.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Zammit NW, Walters SN, Seeberger KL, O'Connell PJ, Korbutt GS, Grey ST. A20 as an immune tolerance factor can determine islet transplant outcomes. JCI Insight. 2019 11 01; 4(21). PMID: 31581152.
    Citations: 6     Fields:    Translation:Humans
  7. Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, Zahra D, Chaudhri G, Karupiah G, Whittle B, Roots C, Bertram E, Yamada M, Jeelall Y, Enders A, Clifton BE, Mabbitt PD, Jackson CJ, Watson SR, Jenne CN, Lanier LL, Wiltshire T, Spitzer MH, Nolan GP, Schmitz F, Aderem A, Porebski BT, Buckle AM, Abbott DW, Ziegler JB, Craig ME, Benitez-Aguirre P, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST. Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity. Nat Immunol. 2019 10; 20(10):1299-1310. PMID: 31534238.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  8. Zammit NW, Grey ST. Equipping the islet graft for self defence: targeting nuclear factor ?B and implications for tolerance. Curr Opin Organ Transplant. 2018 02; 23(1):97-105. PMID: 29120883.
    Citations: 1     Fields:    Translation:HumansAnimals
  9. Schuetz C, Anazawa T, Cross SE, Labriola L, Meier RPH, Redfield RR, Scholz H, Stock PG, Zammit NW. ß Cell Replacement Therapy: The Next 10 Years. Transplantation. 2018 02; 102(2):215-229. PMID: 28885496.
    Citations: 14     Fields:    Translation:HumansCells
  10. Hsu AC, Dua K, Starkey MR, Haw TJ, Nair PM, Nichol K, Zammit N, Grey ST, Baines KJ, Foster PS, Hansbro PM, Wark PA. MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD. JCI Insight. 2017 04 06; 2(7):e90443. PMID: 28405612.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  11. Villanueva JE, Walters SN, Saito M, Malle EK, Zammit NW, Watson KA, Brink R, La Gruta NL, Alexander SI, Grey ST. Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice. Diabetologia. 2017 04; 60(4):679-689. PMID: 28062921.
    Citations: 3     Fields:    Translation:AnimalsCells
  12. Malle EK, Zammit NW, Walters SN, Koay YC, Wu J, Tan BM, Villanueva JE, Brink R, Loudovaris T, Cantley J, McAlpine SR, Hesselson D, Grey ST. Nuclear factor ?B-inducing kinase activation as a mechanism of pancreatic ß cell failure in obesity. J Exp Med. 2015 Jul 27; 212(8):1239-54. PMID: 26122662; PMCID: PMC4516791.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  13. Villanueva JE, Malle EK, Gardam S, Silveira PA, Zammit NW, Walters SN, Brink R, Grey ST. TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15. Eur J Immunol. 2015 Jun; 45(6):1820-31. PMID: 25931426.
    Citations: 7     Fields:    Translation:AnimalsCells
  14. Zammit NW, Grey ST. Emerging roles for A20 in islet biology and pathology. Adv Exp Med Biol. 2014; 809:141-62. PMID: 25302370.
    Citations: 3     Fields:    Translation:Humans
  15. Zammit NW, Tan BM, Walters SN, Liuwantara D, Villanueva JE, Malle EK, Grey ST. Low-dose rapamycin unmasks the protective potential of targeting intragraft NF-?B for islet transplants. Cell Transplant. 2013; 22(12):2355-66. PMID: 23127588.
    Citations: 8     Fields:    Translation:AnimalsCells
  16. Wyatt AR, Zammit NW, Wilson MR. Acute phase proteins are major clients for the chaperone action of a2-macroglobulin in human plasma. Cell Stress Chaperones. 2013 Mar; 18(2):161-70. PMID: 22896034.
    Citations: 7     Fields:    Translation:HumansCells
  17. Cowley MJ, Weinberg A, Zammit NW, Walters SN, Hawthorne WJ, Loudovaris T, Thomas H, Kay T, Gunton JE, Alexander SI, Kaplan W, Chapman J, O'Connell PJ, Grey ST. Human islets express a marked proinflammatory molecular signature prior to transplantation. Cell Transplant. 2012; 21(9):2063-78. PMID: 22404979.
    Citations: 33     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.