Harvard Catalyst Profiles

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Shambhu Yadav, Ph.D.

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Biography
education and training
Brigham and Women’s Hospital, Harvard Medical School, Boston, USAWorkingNeurovascular System
University of Tennessee Health Science Center - Memphis, USA10/2020Postdoc in Cardiovascular physiology
Indian Institute of Science Education and Research Mohali, IndiaPhD07/2019Redox Biochemistry: Sulfur Metabolism (Glutathione Cycle)
Indian Institute of Science Education and Research Mohali, IndiaInt. MS05/2014Life Sciences
awards and honors
2022
GRS best talk award sponsored by sFRBM at GRS/GRC NOX Family NADPH Oxidases
2018
Travel Award to present PhD Thesis work in the European Calcium Society (E.C.S) Meeting 2018.
2015 - 2019
DST-INSPIRE Fellowship provided by Department of Science and Technology, India
2009 - 2014
DST-INSPIRE Scholarship
2014
JRF by Wellcome Trust-DBT India Alliance

Overview
overview
I am passionately focused on redox metabolism and oxidant-modulated signaling in both cell and animal models. Currently, I am studying the signal transduction in the cardiovascular and neurovascular system in health and disease with a focus on using chemogenetic approaches to dissect the role of cellular oxidants in neurodegenerative diseases.
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Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Waldeck-Weiermair M, Yadav S, Kaynert J, Thulabandu VR, Pandey AK, Spyropoulos F, Covington T, Das AA, Krüger C, Michel T. Differential endothelial hydrogen peroxide signaling via Nox isoforms: Critical roles for Rac1 and modulation by statins. Redox Biol. 2022 12; 58:102539. PMID: 36401888; PMCID: PMC9673117.
    Citations:    Fields:    Translation:HumansCells
  2. Pandey AK, Waldeck-Weiermair M, Wells QS, Xiao W, Yadav S, Eroglu E, Michel T, Loscalzo J. Expression of CD70 Modulates Nitric Oxide and Redox Status in Endothelial Cells. Arterioscler Thromb Vasc Biol. 2022 09; 42(9):1169-1185. PMID: 35924558; PMCID: PMC9394499.
    Citations:    Fields:    Translation:HumansCells
  3. Dieniffer Peixoto-Neves, Shambhu Yadav, Charles Mackay, M Dennis Leo, Alejandro Mata-Daboin, Ulrich C Mbiakop, Jonathan H Jaggar. Vasodilators stimulate SK3 channel anterograde trafficking in endothelial cells to elicit vasodilation. 2022; 36(S1):R3871. View Publication.
  4. Waldeck-Weiermair M, Yadav S, Spyropoulos F, Krüger C, Pandey AK, Michel T. Dissecting in vivo and in vitro redox responses using chemogenetics. Free Radic Biol Med. 2021 12; 177:360-369. PMID: 34752919; PMCID: PMC8639655.
    Citations: 3     Fields:    Translation:AnimalsCells
  5. Bachhawat AK, Yadav S, Jainarayanan AK, Dubey P. Heart failure and the glutathione cycle: an integrated view. Biochem J. 2020 09 18; 477(17):3123-3130. PMID: 32886767.
    Citations: 5     Fields:    Translation:HumansAnimals
  6. Yadav S, Chawla B, Khursheed MA, Ramachandran R, Bachhawat AK. Correction: The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium. Biochem J. 2020 02 28; 477(4):815. PMID: 32106303.
    Citations:    Fields:    
  7. Yadav S, Mody TA, Sharma A, Bachhawat AK. A Genetic Screen To Identify Genes Influencing the Secondary Redox Couple NADPH/NADP+ in the Yeast Saccharomyces cerevisiae. G3 (Bethesda). 2020 01 07; 10(1):371-378. PMID: 31757928.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Jainarayanan AK, Yadav S, Bachhawat AK. Yeast glutaredoxin, GRX4, functions as a glutathione S-transferase required for red ade pigment formation in Saccharomyces cerevisiae. J Biosci. 2020; 45. PMID: 32098918.
    Citations:    Fields:    Translation:AnimalsCells
  9. Shambhu Yadav And Anand K Bachhawat. Studies on altered glutathione metabolism in Zebrafish and the yeast Saccharomyces cerevisiae. 2019.
  10. Yadav S, Chawla B, Khursheed MA, Ramachandran R, Bachhawat AK. The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium. Biochem J. 2019 07 02; 476(13):1857-1873. PMID: 31189567.
    Citations: 2     Fields:    Translation:AnimalsCells
  11. Bachhawat AK, Yadav S. The glutathione cycle: Glutathione metabolism beyond the ?-glutamyl cycle. IUBMB Life. 2018 07; 70(7):585-592. PMID: 29667297.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  12. Zulkifli M, Yadav S, Thakur A, Singla S, Sharma M, Bachhawat AK. Substrate specificity and mapping of residues critical for transport in the high-affinity glutathione transporter Hgt1p. Biochem J. 2016 08 01; 473(15):2369-82. PMID: 27252386.
    Citations: 1     Fields:    Translation:AnimalsCells
  13. Shambhu Yadav and Anand K Bachhawat. Mutational Study of the Transmembrane Domains of the Yeast Glutathione Transporter, Hgt1p of Saccharomyces cerevisiae. 2014.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.