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Alejandro Bertolet, Ph.D.

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Universidad de Sevilla, Seville, SpainBS09/2014Physics
Hospital Universitario Virgen Macarena, Seville, SpainMedPhys05/2018Clinical Medical Physics
Universidad Nacional de Educación a Distancia, Madrid, SpainMSc06/2018Medical Physics
Universidad de Sevilla, Seville, SpainPhD09/2020Radiation Biophysics


Available: 12/01/23, Expires: 09/01/24

Transarterial radioembolization (TARE) is one of the therapeutic options to treat unresectable hepatocellular carcinoma (HCC) and other liver-related cancers. This procedure employs microspheres equipped with a radioactive isotope delivered through the hepatic artery so that they get lodged in the small vessels near the tumor. This is favored by the preferential blood flow towards the tumor with respect to the healthy liver. Radiation emitted near the tumor is utilized for therapeutic effect. Despite the success of TARE as an effective treatment for HCC, patient-specific optimization is expected to lead to large improvements in treatment response. In this project, the student will join a multi-disciplinary team, including physicians, physicists, and machine-learning engineers, to study the patient-specific factors and biomarkers impacting the response to TARE treatments, as well as the relationship between radiation dose and clinical outcomes.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 1R21CA279068-01 (BERTOLET REINA, ALEJANDRO) Sep 8, 2023 - Sep 7, 2025
    GPU-based SPECT reconstruction using reverse Monte Carlo simulations
    Role Description: This project explores a GPU-accelerated Monte Carlo method with reverse physics for SPECT reconstruction
    Role: PI
  2. 1R01CA278882-01 (PRYMA, DANIEL) Sep 1, 2023 - Aug 31, 2028
    Optimizing theranostic radiopharmaceutical therapy to combat resistance to PARP inhibition in advanced ovarian cancer
    Role Description: In this project, we aim to better understand the comparative radiobiology of the alpha emitting drug [211At]PTT in tumor and normal tissues. We will develop an optimized strategy for translation to clinical trials in women with advanced PARPi resistant ovarian cancer. The PET imaging companion diagnostic [18F]FTT will be developed in parallel as a prognostic biomarker as well as for image-guided treatment planning.
    Role: Site PI
  3. 2022 Warshaw Institute Research Pilot Grant Fundin (BERTOLET REINA, ALEJANDRO) Jul 1, 2022 - Dec 31, 2023
    Andrew L. Warshaw, M.D., Institute for Pancreatic Cancer Research, Massachusetts General Hospital
    Radiobiological modeling of alpha-particle radiopharmaceutical therapy for pancreatic adenocarcinoma
    Role Description: Providing valuable knowledge to guide the design of new pre-clinical studies in which our results can be validated; and modeling different factors impacting the dosimetry and biological effects of a-particles with the future ambition of optimizing clinical treatments of pancreatic ductal adenocarcinoma.
  4. K99CA267560 (BERTOLET REINA, ALEJANDRO) Dec 10, 2021 - Nov 30, 2023
    Radiation dosimetry for alpha-particle radiopharmaceutical therapy and application to pediatric neuroblastoma
    Role Description: The project will study radiopharmaceutical treatments with a-particles, focusing on the treatment of pediatric neuroblastoma using the radiopharmaceutical [211At]MM4, which targets the overexpression of PARP-1 proteins in pediatric neuroblastoma tumors.

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.