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Alejandro Bertolet, Ph.D.

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Universidad de Sevilla, Seville, SpainBS09/2014Physics
Hospital Universitario Virgen Macarena, Seville, SpainMedPhys05/2018Clinical Medical Physics
Universidad Nacional de Educación a Distancia, Madrid, SpainMSc06/2018Medical Physics
Universidad de Sevilla, Seville, SpainPhD09/2020Radiation Biophysics


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K99CA267560 (ALEJANDRO BERTOLET REINA) Dec 10, 2021 - Nov 30, 2023
    Radiation dosimetry for alpha-particle radiopharmaceutical therapy and application to pediatric neuroblastoma
    Role Description: The use of a-emitting radionuclides is rapidly growing as a promising approach to treat several types of cancer and metastases. In these radiation-based treatments, maximizing efficacy while minimizing non-desired toxicities is only achievable through an accurate knowledge and prediction of the a radiation interaction with the organism. This project will contribute decisively to a rigorous and complete determination of the radiation dosimetry and biological effects of a-particles in the context of radiopharmaceutical treatments

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bertolet A, Wehrenberg-Klee E, Bobic M, Grassberger C, Perl J, Paganetti H, Schuemann J. Pre- and post-treatment image-based dosimetry in90Y-microsphere radioembolization using the TOPAS Monte Carlo toolkit. Phys Med Biol. 2021 Dec 29; 66(24). PMID: 34915451.
    Citations:    Fields:    
  2. Baratto-Roldán A, Bertolet A, Baiocco G, Carabe A, Cortés-Giraldo MA. Microdosimetry and Dose-Averaged LET Calculations of Protons in Liquid Water: A Novel Geant4-DNA Application. Frontiers in Physics. 2021; 9(October):726787. View Publication.
  3. Bertolet A, Abolfath R, Carlson DJ, Lustig RA, Hill-Kayser C, Alonso-Basanta M, Carabe A. Correlation of LET With MRI Changes in Brain and Potential Implications for Normal Tissue Complication Probability for Patients With Meningioma Treated With Pencil Beam Scanning Proton Therapy. Int J Radiat Oncol Biol Phys. 2022 01 01; 112(1):237-246. PMID: 34425196.
    Citations: 1     Fields:    Translation:HumansCells
  4. Bertolet A, Ramos-Méndez J, Paganetti H, Schuemann J. The relation between microdosimetry and induction of direct damage to DNA by alpha particles. Phys Med Biol. 2021 07 30; 66(15). PMID: 34280910.
    Citations:    Fields:    
  5. Miras Del Río H, Ortiz Lora A, Bertolet Reina A, Terrón León JA. A Monte Carlo dose calculation system for ophthalmic brachytherapy based on a realistic eye model. Med Phys. 2021 Aug; 48(8):4542-4559. PMID: 34250607.
    Citations:    Fields:    Translation:Humans
  6. Bertolet A, Cortés-Giraldo MA, Carabe-Fernandez A. Implementation of the microdosimetric kinetic model using analytical microdosimetry in a treatment planning system for proton therapy. Phys Med. 2021 Jan; 81:69-76. PMID: 33440283.
    Citations: 1     Fields:    Translation:Humans
  7. Bertolet A, Wals A, Miras H, Macías J. Organic generation of real-world real-time data for clinical evidence in radiation oncology. Int J Med Inform. 2020 12; 144:104301. PMID: 33091831.
    Citations:    Fields:    Translation:Humans
  8. Bertolet A, Cortés-Giraldo MA, Carabe-Fernandeza A. An Analytical Microdosimetric Model for Radioimmunotherapeutic Alpha Emitters. Radiat Res. 2020 10 02; 194(4):403-410. PMID: 33045091.
    Citations: 1     Fields:    Translation:Cells
  9. Carabe A, Karagounis IV, Huynh K, Bertolet A, François N, Kim MM, Maity A, Abel E, Dale R. Radiobiological effectiveness difference of proton arc beams versus conventional proton and photon beams. Phys Med Biol. 2020 08 31; 65(16):165002. PMID: 32413889.
    Citations: 5     Fields:    Translation:Humans
  10. Bertolet A, Carabe A. Modelling Dose Effects from Space Irradiations: Combination of High-LET and Low-LET Radiations with a Modified Microdosimetric Kinetic Model. Life (Basel). 2020 Aug 23; 10(9). PMID: 32842519.
    Citations: 1     
  11. Bertolet A, Carabe A. Proton monoenergetic arc therapy (PMAT) to enhance LETd within the target. Phys Med Biol. 2020 08 19; 65(16):165006. PMID: 32428896.
    Citations: 3     Fields:    Translation:HumansCells
  12. Bertolet A, Grilj V, Guardiola C, Harken AD, Cortés-Giraldo MA, Baratto-Roldán A, Carabe A. Experimental validation of an analytical microdosimetric model based on Geant4-DNA simulations by using a silicon-based microdosimeter. Radiat Phys Chem Oxf Engl 1993. 2020 Nov; 176. PMID: 33100611.
  13. Bertolet A, Carabe-Fernandez A. Clinical implications of variable relative biological effectiveness in proton therapy for prostate cancer. Acta Oncol. 2020 Oct; 59(10):1171-1177. PMID: 32427011.
    Citations:    Fields:    Translation:HumansCells
  14. Bertolet A, Cortés-Giraldo MA, Carabe-Fernandez A. On the concepts of dose-mean lineal energy, unrestricted and restricted dose-averaged LET in proton therapy. Phys Med Biol. 2020 04 02; 65(7):075011. PMID: 32023557.
    Citations: 2     Fields:    Translation:HumansCells
  15. Bertolet A, Cortés-Giraldo MA, Souris K, Carabe A. A kernel-based algorithm for the spectral fluence of clinical proton beams to calculate dose-averaged LET and other dosimetric quantities of interest. Med Phys. 2020 Jun; 47(6):2495-2505. PMID: 32124463.
    Citations: 3     Fields:    Translation:Cells
  16. Carabe-Fernandez A, Bertolet-Reina A, Karagounis I, Huynh K, Dale RG. Is there a role for arcing techniques in proton therapy? Br J Radiol. 2020 Mar 01; 93(1107):20190469. PMID: 31860338.
    Citations: 6     Fields:    Translation:Humans
  17. Bertolet A, Cortés-Giraldo MA, Souris K, Cohilis M, Carabe-Fernandez A. Calculation of clinical dose distributions in proton therapy from microdosimetry. Med Phys. 2019 Dec; 46(12):5816-5823. PMID: 31603992.
    Citations: 1     Fields:    
  18. Bertolet A, Baratto-Roldán A, Cortés-Giraldo MA, Carabe-Fernandez A. Segment-averaged LET concept and analytical calculation from microdosimetric quantities in proton radiation therapy. Med Phys. 2019 Sep; 46(9):4204-4214. PMID: 31228264.
    Citations: 4     Fields:    Translation:Cells
  19. Bertolet A, Baratto-Roldán A, Barbieri S, Baiocco G, Carabe A, Cortés-Giraldo MA. Dose-averaged LET calculation for proton track segments using microdosimetric Monte Carlo simulations. Med Phys. 2019 Sep; 46(9):4184-4192. PMID: 31169910.
    Citations: 3     Fields:    Translation:Cells
  20. Miras H, Jiménez R, Perales Á, Terrón JA, Bertolet A, Ortiz A, Macías J. Monte Carlo verification of radiotherapy treatments with CloudMC. Radiat Oncol. 2018 Jun 27; 13(1):99. PMID: 29945681.
    Citations: 3     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.