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Takahiko Imai, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lyden PD, Bosetti F, Diniz MA, Rogatko A, Koenig JI, Lamb J, Nagarkatti KA, Cabeen RP, Hess DC, Kamat PK, Khan MB, Wood K, Dhandapani K, Arbab AS, Leira EC, Chauhan AK, Dhanesha N, Patel RB, Kumskova M, Thedens D, Morais A, Imai T, Qin T, Ayata C, Boisserand LSB, Herman AL, Beatty HE, Velazquez SE, Diaz-Perez S, Sanganahalli BG, Mihailovic JM, Hyder F, Sansing LH, Koehler RC, Lannon S, Shi Y, Karuppagounder SS, Bibic A, Akhter K, Aronowski J, McCullough LD, Chauhan A, Goh A. The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results. Stroke. 2022 Mar 31; 101161STROKEAHA121038047. PMID: 35354299.
    Citations:    Fields:    
  2. Oka F, Lee JH, Yuzawa I, Li M, von Bornstaedt D, Eikermann-Haerter K, Qin T, Chung DY, Sadeghian H, Seidel JL, Imai T, Vuralli D, Platt RF, Nelson MT, Joutel A, Sakadzic S, Ayata C. CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis. J Clin Invest. 2022 Feb 24. PMID: 35202003.
    Citations:    Fields:    
  3. Matsubara H, Imai T, Tsuji S, Oka N, Egashira Y, Enomoto Y, Nakayama N, Nakamura S, Shimazawa M, Iwama T, Hara H. Corrigendum to 'Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice' [Journal of Pharmacological Sciences 148 (2022) 65-72]. J Pharmacol Sci. 2022 Feb; 148(2):279. PMID: 35063144.
    Citations:    Fields:    
  4. Akifuji C, Iwasaki M, Kawahara Y, Sakurai C, Cheng YS, Imai T, Nakagawa M. MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains. Sci Rep. 2021 12 20; 11(1):24254. PMID: 34930932.
    Citations:    Fields:    Translation:HumansCells
  5. Matsubara H, Imai T, Tsuji S, Oka N, Egashira Y, Enomoto Y, Nakayama N, Nakamura S, Shimazawa M, Iwama T, Hara H. Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice. J Pharmacol Sci. 2022 Jan; 148(1):65-72. PMID: 34924132.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Matsubara H, Imai T, Tsuji S, Oka N, Ohba T, Yamada T, Egashira Y, Nakamura S, Shimazawa M, Iwama T, Hara H. Involvement of Cerebral Blood Flow on Neurological and Behavioral Functions after Subarachnoid Hemorrhage in Mice. J Stroke Cerebrovasc Dis. 2021 Sep; 30(9):105952. PMID: 34214963.
    Citations:    Fields:    Translation:Animals
  7. Nishinaka A, Nakamura S, Tanaka M, Masuda T, Inoue Y, Yamamoto T, Imai T, Hidaka Y, Shimazawa M, Hara H. Excess adiponectin in eyes with progressive ocular vascular diseases. FASEB J. 2021 02; 35(2):e21313. PMID: 33484194.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  8. Imai T, Matsubara H, Hara H. Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage. J Cereb Blood Flow Metab. 2021 07; 41(7):1483-1500. PMID: 33444090.
    Citations: 1     Fields:    Translation:HumansAnimals
  9. Tanaka M, Inoue Y, Imai T, Tanida N, Takahashi K, Hara H. Guanabenz and Clonidine, a2-Adrenergic Receptor Agonists, Inhibit Choroidal Neovascularization. Curr Neurovasc Res. 2021; 18(1):85-92. PMID: 34011258.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Tsuji S, Nakamura S, Maoka T, Yamada T, Imai T, Ohba T, Yako T, Hayashi M, Endo K, Saio M, Hara H, Shimazawa M. Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma. Mar Drugs. 2020 Sep 18; 18(9). PMID: 32962073.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  11. Matsubara H, Imai T, Yamada T, Egashira Y, Nakamura S, Shimazawa M, Iwama T, Hara H. Importance of CBF measurement to exclude concomitant cerebral infarction in the murine endovascular perforation SAH model. J Stroke Cerebrovasc Dis. 2020 Nov; 29(11):105243. PMID: 33066951.
    Citations:    Fields:    Translation:Animals
  12. Imai T, Tsuji S, Matsubara H, Ohba T, Sugiyama T, Nakamura S, Hara H, Shimazawa M. Deferasirox, a trivalent iron chelator, ameliorates neuronal damage in hemorrhagic stroke models. Naunyn Schmiedebergs Arch Pharmacol. 2021 01; 394(1):73-84. PMID: 32808069.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Nakamura S, Saito Y, Gouda T, Imai T, Shimazawa M, Nishimura Y, Hara H. Therapeutic Effects of Iron Chelation in Atorvastatin-Induced Intracranial Hemorrhage of Zebrafish Larvae. J Stroke Cerebrovasc Dis. 2020 Nov; 29(11):105215. PMID: 33066911.
    Citations: 2     Fields:    Translation:Animals
  14. Imai T, Matsubara H, Nakamura S, Hara H, Shimazawa M. The Mitochondria-targeted Peptide, Bendavia, Attenuated Ischemia/Reperfusion-induced Stroke Damage. Neuroscience. 2020 09 01; 443:110-119. PMID: 32738431.
    Citations: 6     Fields:    Translation:AnimalsCells
  15. Imai T, Sugiyama T, Iwata S, Nakamura S, Shimazawa M, Hara H. Levetiracetam, an Antiepileptic Drug has Neuroprotective Effects on Intracranial Hemorrhage Injury. Neuroscience. 2020 04 01; 431:25-33. PMID: 32058064.
    Citations:    Fields:    Translation:HumansAnimals
  16. Imai T, Iwata S, Miyo D, Nakamura S, Shimazawa M, Hara H. A novel free radical scavenger, NSP-116, ameliorated the brain injury in both ischemic and hemorrhagic stroke models. J Pharmacol Sci. 2019 Nov; 141(3):119-126. PMID: 31679961.
    Citations: 7     Fields:    Translation:HumansAnimals
  17. Imai T, Iwata S, Hirayama T, Nagasawa H, Nakamura S, Shimazawa M, Hara H. Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage. Sci Rep. 2019 04 17; 9(1):6228. PMID: 30996325.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  18. Hyakkoku K, Umeda N, Shimada S, Imai T, Morioka Y, Sakaguchi G, Hara H. Post-stroke pain caused by peripheral sensory hypersensitization after transient focal cerebral ischemia in rats. Brain Res. 2019 07 15; 1715:35-40. PMID: 30898673.
    Citations:    Fields:    Translation:AnimalsCells
  19. Imai T, Tanaka H, Hamazaki Y, Minato N. Rap1 signal modulators control the maintenance of hematopoietic progenitors in bone marrow and adult long-term hematopoiesis. Cancer Sci. 2019 Apr; 110(4):1317-1330. PMID: 30767320.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Sugiyama T, Imai T, Nakamura S, Yamauchi K, Sawada S, Shimazawa M, Hara H. A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase. Brain Res. 2018 12 15; 1701:137-145. PMID: 30142309.
    Citations: 15     Fields:    Translation:AnimalsCells
  21. Iwata S, Imai T, Shimazawa M, Ishibashi T, Hayashi M, Hara H, Nakamura S. Protective effects of the astaxanthin derivative, adonixanthin, on brain hemorrhagic injury. Brain Res. 2018 11 01; 1698:130-138. PMID: 30092231.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  22. Yamauchi K, Imai T, Shimazawa M, Iwama T, Hara H. Effects of ticagrelor in a mouse model of ischemic stroke. Sci Rep. 2017 09 21; 7(1):12088. PMID: 28935927.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  23. Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y. Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis. J Clin Invest. 2017 Oct 02; 127(10):3784-3795. PMID: 28891812.
    Citations: 16     Fields:    Translation:AnimalsCells
  24. Imai T, Matsukawa H, Takagi T, Tsuruma K, Shimazawa M, Hara H. The phosphodiesterase III inhibitor cilostazol protects the brain microvasculature from collagenase injury. Neuroreport. 2017 Jul 05; 28(10):555-560. PMID: 28574925.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  25. Uotani Y, Kitahara R, Imai T, Tsutsumi N, Sasakawa C, Nagai S, Nagano T. Efficacy of an avian colibacillosis live vaccine for layer breeder in Japan. J Vet Med Sci. 2017 Jul 19; 79(7):1215-1219. PMID: 28603216.
    Citations:    Fields:    Translation:Animals
  26. Imai T, Mishiro K, Takagi T, Isono A, Nagasawa H, Tsuruma K, Shimazawa M, Hara H. Protective Effect of Bendavia (SS-31) Against Oxygen/Glucose-Deprivation Stress-Induced Mitochondrial Damage in Human Brain Microvascular Endothelial Cells. Curr Neurovasc Res. 2017; 14(1):53-59. PMID: 27855593.
    Citations: 4     Fields:    Translation:HumansCells
  27. Yamauchi K, Nakano Y, Imai T, Takagi T, Tsuruma K, Shimazawa M, Iwama T, Hara H. A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice. Neuroscience. 2016 10 01; 333:302-10. PMID: 27474227.
    Citations: 17     Fields:    Translation:Animals
  28. Imai T, Takagi T, Kitashoji A, Yamauchi K, Shimazawa M, Hara H. Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation. Neurobiol Dis. 2016 May; 89:136-46. PMID: 26850917.
    Citations: 17     Fields:    Translation:AnimalsCells
  29. Takagi T, Imai T, Mishiro K, Ishisaka M, Tsujimoto M, Ito H, Nagashima K, Matsukawa H, Tsuruma K, Shimazawa M, Yoshimura S, Kozawa O, Iwama T, Hara H. Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood-brain barrier. J Cereb Blood Flow Metab. 2017 01; 37(1):123-139. PMID: 26661252.
    Citations: 13     Fields:    Translation:AnimalsCells
  30. Supper E, Tahir S, Imai T, Inoue J, Minato N. Modification of Gene Expression, Proliferation, and Function of OP9 Stroma Cells by Bcr-Abl-Expressing Leukemia Cells. PLoS One. 2015; 10(7):e0134026. PMID: 26218064.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  31. Doi K, Imai T, Kressler C, Yagita H, Agata Y, Vooijs M, Hamazaki Y, Inoue J, Minato N. Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia. Sci Rep. 2015 Jan 23; 5:7978. PMID: 25613394.
    Citations: 7     Fields:    Translation:AnimalsCells
  32. Sato A, Suwanto A, Okabe M, Sato S, Nochi T, Imai T, Koyanagi N, Kunisawa J, Kawaguchi Y, Kiyono H. Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease. J Virol. 2014 Dec; 88(23):13699-708. PMID: 25231301.
    Citations: 19     Fields:    Translation:AnimalsCells
  33. Mishiro K, Imai T, Sugitani S, Kitashoji A, Suzuki Y, Takagi T, Chen H, Oumi Y, Tsuruma K, Shimazawa M, Hara H. Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis. PLoS One. 2014; 9(8):e103818. PMID: 25133692.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  34. Koyanagi N, Imai T, Arii J, Kato A, Kawaguchi Y. Role of herpes simplex virus 1 Us3 in viral neuroinvasiveness. Microbiol Immunol. 2014 Jan; 58(1):31-7. PMID: 24200420.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  35. Imai T, Koyanagi N, Ogawa R, Shindo K, Suenaga T, Sato A, Arii J, Kato A, Kiyono H, Arase H, Kawaguchi Y. Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells. PLoS One. 2013; 8(8):e72050. PMID: 23951282.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  36. Kuroiwa Y, Takakusagi Y, Kusayanagi T, Kuramochi K, Imai T, Hirayama T, Ito I, Yoshida M, Sakaguchi K, Sugawara F. Identification and characterization of the direct interaction between methotrexate (MTX) and high-mobility group box 1 (HMGB1) protein. PLoS One. 2013; 8(5):e63073. PMID: 23658798.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  37. Kato A, Liu Z, Minowa A, Imai T, Tanaka M, Sugimoto K, Nishiyama Y, Arii J, Kawaguchi Y. Herpes simplex virus 1 protein kinase Us3 and major tegument protein UL47 reciprocally regulate their subcellular localization in infected cells. J Virol. 2011 Sep; 85(18):9599-613. PMID: 21734045.
    Citations: 26     Fields:    Translation:AnimalsCells
  38. Imai T, Arii J, Minowa A, Kakimoto A, Koyanagi N, Kato A, Kawaguchi Y. Role of the herpes simplex virus 1 Us3 kinase phosphorylation site and endocytosis motifs in the intracellular transport and neurovirulence of envelope glycoprotein B. J Virol. 2011 May; 85(10):5003-15. PMID: 21389132.
    Citations: 20     Fields:    Translation:AnimalsCells
  39. Arii J, Goto H, Suenaga T, Oyama M, Kozuka-Hata H, Imai T, Minowa A, Akashi H, Arase H, Kawaoka Y, Kawaguchi Y. Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1. Nature. 2010 Oct 14; 467(7317):859-62. PMID: 20944748.
    Citations: 117     Fields:    Translation:HumansAnimalsCells
  40. Imai T, Sagou K, Arii J, Kawaguchi Y. Effects of phosphorylation of herpes simplex virus 1 envelope glycoprotein B by Us3 kinase in vivo and in vitro. J Virol. 2010 Jan; 84(1):153-62. PMID: 19846518.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  41. Konno H, Yamamoto T, Yamazaki K, Gohda J, Akiyama T, Semba K, Goto H, Kato A, Yujiri T, Imai T, Kawaguchi Y, Su B, Takeuchi O, Akira S, Tsunetsugu-Yokota Y, Inoue J. TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA. PLoS One. 2009 May 25; 4(5):e5674. PMID: 19479062.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  42. Sagou K, Imai T, Sagara H, Uema M, Kawaguchi Y. Regulation of the catalytic activity of herpes simplex virus 1 protein kinase Us3 by autophosphorylation and its role in pathogenesis. J Virol. 2009 Jun; 83(11):5773-83. PMID: 19297494.
    Citations: 32     Fields:    Translation:AnimalsCells
  43. Saitoh T, Kuramochi K, Imai T, Takata K, Takehara M, Kobayashi S, Sakaguchi K, Sugawara F. Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro. Bioorg Med Chem. 2008 May 15; 16(10):5815-25. PMID: 18396405.
    Citations: 3     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.