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Takahiko Imai, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Morais A, Locascio JJ, Sansing LH, Lamb J, Nagarkatti K, Imai T, van Leyen K, Aronowski J, Koenig JI, Bosetti F, Lyden P, Ayata C. Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial. Stroke. 2023 Feb; 54(2):620-631. PMID: 36601951; PMCID: PMC9870939.
    Citations:    Fields:    Translation:Animals
  2. Oka N, Doan VTH, Matsubara H, Imai T, Yoshioka Y, Katsuki J, Fujii S, Nakamura S, Shimazawa M, Hara H, Sakurai K. Protective effects of alpha-mangostin encapsulated in cyclodextrin-nanoparticle on cerebral ischemia. J Control Release. 2023 01; 353:216-228. PMID: 36410615.
    Citations:    Fields:    Translation:HumansAnimals
  3. Oka F, Lee JH, Yuzawa I, Li M, von Bornstaedt D, Eikermann-Haerter K, Qin T, Chung DY, Sadeghian H, Seidel JL, Imai T, Vuralli D, Platt RM, Nelson MT, Joutel A, Sakadzic S, Ayata C. CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis. J Clin Invest. 2022 04 15; 132(8). PMID: 35202003; PMCID: PMC9012276.
    Citations:    Fields:    Translation:Animals
  4. Lyden PD, Bosetti F, Diniz MA, Rogatko A, Koenig JI, Lamb J, Nagarkatti KA, Cabeen RP, Hess DC, Kamat PK, Khan MB, Wood K, Dhandapani K, Arbab AS, Leira EC, Chauhan AK, Dhanesha N, Patel RB, Kumskova M, Thedens D, Morais A, Imai T, Qin T, Ayata C, Boisserand LSB, Herman AL, Beatty HE, Velazquez SE, Diaz-Perez S, Sanganahalli BG, Mihailovic JM, Hyder F, Sansing LH, Koehler RC, Lannon S, Shi Y, Karuppagounder SS, Bibic A, Akhter K, Aronowski J, McCullough LD, Chauhan A, Goh A. The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results. Stroke. 2022 05; 53(5):1802-1812. PMID: 35354299; PMCID: PMC9038686.
    Citations: 3     Fields:    Translation:HumansAnimals
  5. Matsubara H, Imai T, Tsuji S, Oka N, Egashira Y, Enomoto Y, Nakayama N, Nakamura S, Shimazawa M, Iwama T, Hara H. Corrigendum to 'Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice' [Journal of Pharmacological Sciences 148 (2022) 65-72]. J Pharmacol Sci. 2022 Feb; 148(2):279. PMID: 35063144.
    Citations:    Fields:    
  6. Matsubara H, Imai T, Tsuji S, Oka N, Egashira Y, Enomoto Y, Nakayama N, Nakamura S, Shimazawa M, Iwama T, Hara H. Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice. J Pharmacol Sci. 2022 Jan; 148(1):65-72. PMID: 34924132.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Matsubara H, Imai T, Tsuji S, Oka N, Ohba T, Yamada T, Egashira Y, Nakamura S, Shimazawa M, Iwama T, Hara H. Involvement of Cerebral Blood Flow on Neurological and Behavioral Functions after Subarachnoid Hemorrhage in Mice. J Stroke Cerebrovasc Dis. 2021 Sep; 30(9):105952. PMID: 34214963.
    Citations: 1     Fields:    Translation:Animals
  8. Nishinaka A, Nakamura S, Tanaka M, Masuda T, Inoue Y, Yamamoto T, Imai T, Hidaka Y, Shimazawa M, Hara H. Excess adiponectin in eyes with progressive ocular vascular diseases. FASEB J. 2021 02; 35(2):e21313. PMID: 33484194.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  9. Imai T, Matsubara H, Hara H. Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage. J Cereb Blood Flow Metab. 2021 07; 41(7):1483-1500. PMID: 33444090; PMCID: PMC8221764.
    Citations: 13     Fields:    Translation:HumansAnimals
  10. Tanaka M, Inoue Y, Imai T, Tanida N, Takahashi K, Hara H. Guanabenz and Clonidine, a2-Adrenergic Receptor Agonists, Inhibit Choroidal Neovascularization. Curr Neurovasc Res. 2021; 18(1):85-92. PMID: 34011258.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Tsuji S, Nakamura S, Maoka T, Yamada T, Imai T, Ohba T, Yako T, Hayashi M, Endo K, Saio M, Hara H, Shimazawa M. Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma. Mar Drugs. 2020 Sep 18; 18(9). PMID: 32962073.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  12. Matsubara H, Imai T, Yamada T, Egashira Y, Nakamura S, Shimazawa M, Iwama T, Hara H. Importance of CBF measurement to exclude concomitant cerebral infarction in the murine endovascular perforation SAH model. J Stroke Cerebrovasc Dis. 2020 Nov; 29(11):105243. PMID: 33066951.
    Citations:    Fields:    Translation:Animals
  13. Imai T, Tsuji S, Matsubara H, Ohba T, Sugiyama T, Nakamura S, Hara H, Shimazawa M. Deferasirox, a trivalent iron chelator, ameliorates neuronal damage in hemorrhagic stroke models. Naunyn Schmiedebergs Arch Pharmacol. 2021 01; 394(1):73-84. PMID: 32808069.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  14. Nakamura S, Saito Y, Gouda T, Imai T, Shimazawa M, Nishimura Y, Hara H. Therapeutic Effects of Iron Chelation in Atorvastatin-Induced Intracranial Hemorrhage of Zebrafish Larvae. J Stroke Cerebrovasc Dis. 2020 Nov; 29(11):105215. PMID: 33066911.
    Citations: 2     Fields:    Translation:Animals
  15. Imai T, Matsubara H, Nakamura S, Hara H, Shimazawa M. The Mitochondria-targeted Peptide, Bendavia, Attenuated Ischemia/Reperfusion-induced Stroke Damage. Neuroscience. 2020 09 01; 443:110-119. PMID: 32738431.
    Citations: 7     Fields:    Translation:AnimalsCells
  16. Imai T, Sugiyama T, Iwata S, Nakamura S, Shimazawa M, Hara H. Levetiracetam, an Antiepileptic Drug has Neuroprotective Effects on Intracranial Hemorrhage Injury. Neuroscience. 2020 04 01; 431:25-33. PMID: 32058064.
    Citations: 1     Fields:    Translation:HumansAnimals
  17. Imai T, Iwata S, Miyo D, Nakamura S, Shimazawa M, Hara H. A novel free radical scavenger, NSP-116, ameliorated the brain injury in both ischemic and hemorrhagic stroke models. J Pharmacol Sci. 2019 Nov; 141(3):119-126. PMID: 31679961.
    Citations: 8     Fields:    Translation:HumansAnimals
  18. Imai T, Iwata S, Hirayama T, Nagasawa H, Nakamura S, Shimazawa M, Hara H. Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage. Sci Rep. 2019 04 17; 9(1):6228. PMID: 30996325.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  19. Hyakkoku K, Umeda N, Shimada S, Imai T, Morioka Y, Sakaguchi G, Hara H. Post-stroke pain caused by peripheral sensory hypersensitization after transient focal cerebral ischemia in rats. Brain Res. 2019 07 15; 1715:35-40. PMID: 30898673.
    Citations:    Fields:    Translation:AnimalsCells
  20. Imai T, Tanaka H, Hamazaki Y, Minato N. Rap1 signal modulators control the maintenance of hematopoietic progenitors in bone marrow and adult long-term hematopoiesis. Cancer Sci. 2019 Apr; 110(4):1317-1330. PMID: 30767320; PMCID: PMC6447830.
    Citations: 3     Fields:    Translation:AnimalsCells
  21. Sugiyama T, Imai T, Nakamura S, Yamauchi K, Sawada S, Shimazawa M, Hara H. A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase. Brain Res. 2018 12 15; 1701:137-145. PMID: 30142309.
    Citations: 18     Fields:    Translation:AnimalsCells
  22. Iwata S, Imai T, Shimazawa M, Ishibashi T, Hayashi M, Hara H, Nakamura S. Protective effects of the astaxanthin derivative, adonixanthin, on brain hemorrhagic injury. Brain Res. 2018 11 01; 1698:130-138. PMID: 30092231.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  23. Yamauchi K, Imai T, Shimazawa M, Iwama T, Hara H. Effects of ticagrelor in a mouse model of ischemic stroke. Sci Rep. 2017 09 21; 7(1):12088. PMID: 28935927.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  24. Imai T, Matsukawa H, Takagi T, Tsuruma K, Shimazawa M, Hara H. The phosphodiesterase III inhibitor cilostazol protects the brain microvasculature from collagenase injury. Neuroreport. 2017 Jul 05; 28(10):555-560. PMID: 28574925.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  25. Imai T, Mishiro K, Takagi T, Isono A, Nagasawa H, Tsuruma K, Shimazawa M, Hara H. Protective Effect of Bendavia (SS-31) Against Oxygen/Glucose-Deprivation Stress-Induced Mitochondrial Damage in Human Brain Microvascular Endothelial Cells. Curr Neurovasc Res. 2017; 14(1):53-59. PMID: 27855593.
    Citations: 4     Fields:    Translation:HumansCells
  26. Yamauchi K, Nakano Y, Imai T, Takagi T, Tsuruma K, Shimazawa M, Iwama T, Hara H. A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice. Neuroscience. 2016 10 01; 333:302-10. PMID: 27474227.
    Citations: 22     Fields:    Translation:Animals
  27. Imai T, Takagi T, Kitashoji A, Yamauchi K, Shimazawa M, Hara H. Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation. Neurobiol Dis. 2016 May; 89:136-46. PMID: 26850917.
    Citations: 18     Fields:    Translation:AnimalsCells
  28. Takagi T, Imai T, Mishiro K, Ishisaka M, Tsujimoto M, Ito H, Nagashima K, Matsukawa H, Tsuruma K, Shimazawa M, Yoshimura S, Kozawa O, Iwama T, Hara H. Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood-brain barrier. J Cereb Blood Flow Metab. 2017 01; 37(1):123-139. PMID: 26661252; PMCID: PMC5363736.
    Citations: 15     Fields:    Translation:AnimalsCells
  29. Mishiro K, Imai T, Sugitani S, Kitashoji A, Suzuki Y, Takagi T, Chen H, Oumi Y, Tsuruma K, Shimazawa M, Hara H. Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis. PLoS One. 2014; 9(8):e103818. PMID: 25133692.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.