Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

David Matthew Altshuler, M.D., Ph.D.

Co-Author

This page shows the publications co-authored by David Altshuler and Sekar Kathiresan.
Connection Strength

3.208
  1. Prospective functional classification of all possible missense variants in PPARG. Nat Genet. 2016 12; 48(12):1570-1575.
    View in: PubMed
    Score: 0.171
  2. Association of Exome Sequences With Cardiovascular Traits Among Blacks in the Jackson Heart Study. Circ Cardiovasc Genet. 2016 Aug; 9(4):368-74.
    View in: PubMed
    Score: 0.168
  3. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 2015 Feb 05; 518(7537):102-6.
    View in: PubMed
    Score: 0.150
  4. Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med. 2014 Nov 27; 371(22):2072-82.
    View in: PubMed
    Score: 0.149
  5. Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med. 2014 Jul 03; 371(1):22-31.
    View in: PubMed
    Score: 0.145
  6. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat Genet. 2014 Apr; 46(4):357-63.
    View in: PubMed
    Score: 0.142
  7. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet. 2013 Nov; 45(11):1345-52.
    View in: PubMed
    Score: 0.138
  8. Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nat Genet. 2013 Nov; 45(11):1380-5.
    View in: PubMed
    Score: 0.138
  9. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 2012 Aug 11; 380(9841):572-80.
    View in: PubMed
    Score: 0.126
  10. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012; 8(3):e1002607.
    View in: PubMed
    Score: 0.124
  11. Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. N Engl J Med. 2010 Dec 02; 363(23):2220-7.
    View in: PubMed
    Score: 0.112
  12. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010 Aug 05; 466(7307):707-13.
    View in: PubMed
    Score: 0.111
  13. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet. 2009 Mar; 41(3):334-41.
    View in: PubMed
    Score: 0.100
  14. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009 Jan; 41(1):56-65.
    View in: PubMed
    Score: 0.099
  15. Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes. 2008 Nov; 57(11):3112-21.
    View in: PubMed
    Score: 0.097
  16. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med. 2008 Mar 20; 358(12):1240-9.
    View in: PubMed
    Score: 0.094
  17. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet. 2008 Feb; 40(2):189-97.
    View in: PubMed
    Score: 0.093
  18. Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nat Commun. 2018 06 13; 9(1):2252.
    View in: PubMed
    Score: 0.048
  19. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 2016 08 18; 536(7616):285-91.
    View in: PubMed
    Score: 0.042
  20. A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans. BMC Endocr Disord. 2016 Jan 28; 16:7.
    View in: PubMed
    Score: 0.041
  21. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet. 2015 Dec; 47(12):1415-25.
    View in: PubMed
    Score: 0.040
  22. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014 Dec 25; 371(26):2488-98.
    View in: PubMed
    Score: 0.037
  23. Distribution and medical impact of loss-of-function variants in the Finnish founder population. PLoS Genet. 2014 Jul; 10(7):e1004494.
    View in: PubMed
    Score: 0.037
  24. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014 Mar; 46(3):234-44.
    View in: PubMed
    Score: 0.035
  25. Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet. 2014 Feb 06; 94(2):233-45.
    View in: PubMed
    Score: 0.035
  26. Increased burden of cardiovascular disease in carriers of APOL1 genetic variants. Circ Res. 2014 Feb 28; 114(5):845-50.
    View in: PubMed
    Score: 0.035
  27. Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2013 Dec; 33(12):2909-14.
    View in: PubMed
    Score: 0.034
  28. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2013 Jan; 45(1):25-33.
    View in: PubMed
    Score: 0.033
  29. Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. Am J Hum Genet. 2012 Sep 07; 91(3):513-9.
    View in: PubMed
    Score: 0.032
  30. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet. 2012 Sep; 44(9):981-90.
    View in: PubMed
    Score: 0.032
  31. The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet. 2012; 8(8):e1002793.
    View in: PubMed
    Score: 0.032
  32. Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction. PLoS One. 2012; 7(8):e41730.
    View in: PubMed
    Score: 0.032
  33. Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. Circulation. 2011 Dec 20; 124(25):2855-64.
    View in: PubMed
    Score: 0.030
  34. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11; 478(7367):103-9.
    View in: PubMed
    Score: 0.030
  35. Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction. Nat Genet. 2011 Jul 24; 43(8):801-5.
    View in: PubMed
    Score: 0.030
  36. Influence of 9p21.3 genetic variants on clinical and angiographic outcomes in early-onset myocardial infarction. J Am Coll Cardiol. 2011 Jul 19; 58(4):426-34.
    View in: PubMed
    Score: 0.030
  37. DASH: a method for identical-by-descent haplotype mapping uncovers association with recent variation. Am J Hum Genet. 2011 Jun 10; 88(6):706-717.
    View in: PubMed
    Score: 0.029
  38. A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circ Cardiovasc Genet. 2011 Aug 01; 4(4):403-12.
    View in: PubMed
    Score: 0.029
  39. Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants. Genet Epidemiol. 2011 May; 35(4):236-46.
    View in: PubMed
    Score: 0.029
  40. Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism. J Clin Endocrinol Metab. 2011 Jul; 96(7):E1142-7.
    View in: PubMed
    Score: 0.029
  41. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011 Mar 06; 43(4):333-8.
    View in: PubMed
    Score: 0.029
  42. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet. 2011 Jun 01; 20(11):2273-84.
    View in: PubMed
    Score: 0.029
  43. Testing for an unusual distribution of rare variants. PLoS Genet. 2011 Mar; 7(3):e1001322.
    View in: PubMed
    Score: 0.029
  44. Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction. Atherosclerosis. 2011 Feb; 214(2):397-403.
    View in: PubMed
    Score: 0.028
  45. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol. 2010 Nov 02; 56(19):1552-63.
    View in: PubMed
    Score: 0.028
  46. Common variants at 10 genomic loci influence hemoglobin A1(C) levels via glycemic and nonglycemic pathways. Diabetes. 2010 Dec; 59(12):3229-39.
    View in: PubMed
    Score: 0.028
  47. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet. 2009 Nov; 41(11):1182-90.
    View in: PubMed
    Score: 0.026
  48. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet. 2009 Jun; 41(6):666-76.
    View in: PubMed
    Score: 0.025
  49. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet. 2009 Mar; 41(3):280-2.
    View in: PubMed
    Score: 0.025
  50. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007 Jun 01; 316(5829):1331-6.
    View in: PubMed
    Score: 0.022
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.