Harvard Catalyst Profiles

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Byron Brook, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Dowling DJ, Barman S, Smith AJ, Borriello F, Chaney D, Brightman SE, Melhem G, Brook B, Menon M, Soni D, Schüller S, Siram K, Nanishi E, Bazin HG, Burkhart DJ, Levy O, Evans JT. Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination. Sci Rep. 2022 Oct 18; 12(1):16860. PMID: 36258023; PMCID: PMC9579132.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  2. Barman S, Borriello F, Brook B, Pietrasanta C, De Leon M, Sweitzer C, Menon M, van Haren SD, Soni D, Saito Y, Nanishi E, Yi S, Bobbala S, Levy O, Scott EA, Dowling DJ. Shaping Neonatal Immunization by Tuning the Delivery of Synergistic Adjuvants via Nanocarriers. ACS Chem Biol. 2022 Sep 16; 17(9):2559-2571. PMID: 36028220; PMCID: PMC9486804.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  3. Nanishi E, McGrath ME, O'Meara TR, Barman S, Yu J, Wan H, Dillen CA, Menon M, Seo HS, Song K, Xu AZ, Sebastian L, Brook B, Bosco AN, Borriello F, Ernst RK, Barouch DH, Dhe-Paganon S, Levy O, Frieman MB, Dowling DJ. mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant. Commun Biol. 2022 08 06; 5(1):790. PMID: 35933439; PMCID: PMC9357006.
    Citations: 1     Translation:HumansAnimalsCellsPHPublic Health
  4. Barman S, Soni D, Brook B, Nanishi E, Dowling DJ. Precision Vaccine Development: Cues From Natural Immunity. Front Immunol. 2021; 12:662218. PMID: 35222350; PMCID: PMC8866702.
    Citations:    Fields:    Translation:HumansCells
  5. Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, Prevost-Reilly A, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Sage PT, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice. Sci Transl Med. 2022 Jan 26; 14(629):eabj5305. PMID: 34783582.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  6. Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Brook B, Chen J, Diray-Arce J, Doss-Gollin S, Leon M, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. bioRxiv. 2021 May 21. PMID: 34031655; PMCID: PMC8142652.
    Citations: 1     
  7. Stevens NE, van Wolfswinkel M, Bao W, Ryan FJ, Brook B, Amenyogbe N, Marshall HS, Lynn MA, Kollmann TR, Tumes DJ, Lynn DJ. Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice. Vaccine. 2022 03 08; 40(11):1594-1605. PMID: 33895015.
    Citations: 1     Fields:    Translation:AnimalsPHPublic Health
  8. Brook B, Schaltz-Buchholzer F, Ben-Othman R, Kollmann T, Amenyogbe N. A place for neutrophils in the beneficial pathogen-agnostic effects of the BCG vaccine. Vaccine. 2022 03 08; 40(11):1534-1539. PMID: 33863572.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  9. Brook B, Harbeson DJ, Shannon CP, Cai B, He D, Ben-Othman R, Francis F, Huang J, Varankovich N, Liu A, Bao W, Bjerregaard-Andersen M, Schaltz-Buchholzer F, Sanca L, Golding CN, Larsen KL, Levy O, Kampmann B, Tan R, Charles A, Wynn JL, Shann F, Aaby P, Benn CS, Tebbutt SJ, Kollmann TR, Amenyogbe N. BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis. Sci Transl Med. 2020 05 06; 12(542). PMID: 32376769.
    Citations: 25     Fields:    Translation:HumansPHPublic Health
  10. Brook B, Harbeson D, Amenyogbe N, Ben-Othman R, Kollmann TR, Aniba R. Robust health-score based survival prediction for a neonatal mouse model of polymicrobial sepsis. PLoS One. 2019; 14(6):e0218714. PMID: 31233529; PMCID: PMC6590826.
    Citations: 3     Fields:    Translation:HumansAnimals
  11. Francis F, Varankovich N, Brook B, Amenyogbe N, Ben-Othman R, Cai B, Harbeson D, Liu AC, Dai B, McErlane S, Andrews K, Kollmann TR, Panigrahi P. Probiotic Studies in Neonatal Mice Using Gavage. J Vis Exp. 2019 01 27; (143). PMID: 30741256.
    Citations: 4     Fields:    Translation:Animals
  12. Brook B, Amenyogbe N, Ben-Othman R, Cai B, Harbeson D, Francis F, Liu AC, Varankovich N, Wynn J, Kollmann TR. A Controlled Mouse Model for Neonatal Polymicrobial Sepsis. J Vis Exp. 2019 01 27; (143). PMID: 30741260.
    Citations: 6     Fields:    Translation:HumansAnimals
  13. Brook B, Harbeson D, Ben-Othman R, Viemann D, Kollmann TR. Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen. Semin Immunopathol. 2017 11; 39(6):615-625. PMID: 29098373.
    Citations: 14     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.