Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Amy Jo Wagers, Ph.D.

Other Positions

Investigation into Heterotypic Cell Fusion between Muscle and Hematopoietic Cells
Summer, 05/23/05 - 09/02/05

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13CA236216 (WAGERS, AMY JO) Mar 13, 2019 - Feb 29, 2020
    2019 Stem Cells and Cancer Gordon Research Conference(GRC)and Gordon Research Seminar(GRS)
    Role: Principal Investigator
  2. DP1AG063419 (WAGERS, AMY JO) Sep 30, 2018 - Jun 30, 2023
    Uncovering molecular effectors of mammalian aging
    Role: Principal Investigator
  3. R01HL135287 (WAGERS, AMY JO) Mar 1, 2018 - Feb 28, 2022
    In vivo gene editing of hematopoietic stem and progenitor cells
    Role: Principal Investigator
  4. R01AG057428 (WAGERS, AMY JO) Sep 15, 2017 - May 31, 2021
    Investigating GDF11 and MSTN as candidate circulating geronic factors
    Role: Principal Investigator
  5. R56AG052979 (WAGERS, AMY JO) May 1, 2016 - Apr 30, 2017
    GDF11: an age-variant hormonal regulator of tissue homeostasis and repair
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Flow Cytometry Core (JDC) - Core services (14), Instruments (12) and Software (2)

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yoshida H, Lareau CA, Ramirez RN, Rose SA, Maier B, Wroblewska A, Desland F, Chudnovskiy A, Mortha A, Dominguez C, Tellier J, Kim E, Dwyer D, Shinton S, Nabekura T, Qi Y, Yu B, Robinette M, Kim KW, Wagers A, Rhoads A, Nutt SL, Brown BD, Mostafavi S, Buenrostro JD, Benoist C. The cis-Regulatory Atlas of the Mouse Immune System. Cell. 2019 Feb 07; 176(4):897-912.e20. PMID: 30686579.
    Citations:    Fields:    
  2. Burzyn D, Wagers A, Mathis D, Cerletti M. Methods of Isolation and Analysis of TREG Immune Infiltrates from Injured and Dystrophic Skeletal Muscle. Methods Mol Biol. 2019; 1899:229-237. PMID: 30649776.
    Citations:    Fields:    
  3. Rao TN, Gupta MK, Softic S, Wang LD, Jang YC, Thomou T, Bezy O, Kulkarni RN, Kahn CR, Wagers AJ. Attenuation of PKCd enhances metabolic activity and promotes expansion of blood progenitors. EMBO J. 2018 Dec 14; 37(24). PMID: 30446598.
    Citations:    Fields:    
  4. Goldstein JM, Wagers AJ. What's in a (Sub)strain? Stem Cell Reports. 2018 Aug 14; 11(2):303-305. PMID: 30110622.
    Citations:    Fields:    
  5. Bar-Nur O, Gerli MFM, Di Stefano B, Almada AE, Galvin A, Coffey A, Huebner AJ, Feige P, Verheul C, Cheung P, Payzin-Dogru D, Paisant S, Anselmo A, Sadreyev RI, Ott HC, Tajbakhsh S, Rudnicki MA, Wagers AJ, Hochedlinger K. Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 May 08; 10(5):1505-1521. PMID: 29742392.
    Citations:    Fields:    
  6. Teot LA, Schneider M, Thorner AR, Tian J, Chi YY, Ducar M, Lin L, Wlodarski M, Grier HE, Fletcher CDM, van Hummelen P, Skapek SX, Hawkins DS, Wagers AJ, Rodriguez-Galindo C, Hettmer S. Clinical and mutational spectrum of highly differentiated, paired box 3:forkhead box protein o1 fusion-negative rhabdomyosarcoma: A report from the Children's Oncology Group. Cancer. 2018 May 01; 124(9):1973-1981. PMID: 29461635.
    Citations:    Fields:    
  7. Kadoki M, Patil A, Thaiss CC, Brooks DJ, Pandey S, Deep D, Alvarez D, von Andrian UH, Wagers AJ, Nakai K, Mikkelsen TS, Soumillon M, Chevrier N. Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues. Cell. 2017 Oct 05; 171(2):398-413.e21. PMID: 28942919.
    Citations: 4     Fields:    Translation:AnimalsCells
  8. Sinha I, Sakthivel D, Olenchock BA, Kruse CR, Williams J, Varon DE, Smith JD, Madenci AL, Nuutila K, Wagers AJ. Prolyl Hydroxylase Domain-2 Inhibition Improves Skeletal Muscle Regeneration in a Male Murine Model of Obesity. Front Endocrinol (Lausanne). 2017; 8:153. PMID: 28725215.
    Citations: 1     
  9. Walker RG, Czepnik M, Goebel EJ, McCoy JC, Vujic A, Cho M, Oh J, Aykul S, Walton KL, Schang G, Bernard DJ, Hinck AP, Harrison CA, Martinez-Hackert E, Wagers AJ, Lee RT, Thompson TB. Structural basis for potency differences between GDF8 and GDF11. BMC Biol. 2017 03 03; 15(1):19. PMID: 28257634.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  10. Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB. Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci Transl Med. 2016 11 23; 8(366):366ra163. PMID: 27881824.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  11. Oh J, Sinha I, Tan KY, Rosner B, Dreyfuss JM, Gjata O, Tran P, Shoelson SE, Wagers AJ. Age-associated NF-?B signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function. Aging (Albany NY). 2016 11 14; 8(11):2871-2896. PMID: 27852976.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  12. Maesner CC, Almada AE, Wagers AJ. Established cell surface markers efficiently isolate highly overlapping populations of skeletal muscle satellite cells by fluorescence-activated cell sorting. Skelet Muscle. 2016; 6:35. PMID: 27826411.
    Citations: 6     Fields:    Translation:AnimalsCells
  13. Chew WL, Tabebordbar M, Cheng JK, Mali P, Wu EY, Ng AH, Zhu K, Wagers AJ, Church GM. A multifunctional AAV-CRISPR-Cas9 and its host response. Nat Methods. 2016 10; 13(10):868-74. PMID: 27595405.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  14. Song L, Papaioannou G, Zhao H, Luderer HF, Miller C, Dall'Osso C, Nazarian RM, Wagers AJ, Demay MB. The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury. Endocrinology. 2016 Oct; 157(10):4066-4075. PMID: 27526034.
    Citations: 4     Fields:    Translation:AnimalsCells
  15. Rowe RG, Wang LD, Coma S, Han A, Mathieu R, Pearson DS, Ross S, Sousa P, Nguyen PT, Rodriguez A, Wagers AJ, Daley GQ. Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. J Exp Med. 2016 07 25; 213(8):1497-512. PMID: 27401346.
    Citations: 5     Fields:    Translation:AnimalsCells
  16. Gage FH, Guarente LP, Wagers AJ. Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. Trends Mol Med. 2016 08; 22(8):633-634. PMID: 27396512.
    Citations:    Fields:    Translation:HumansAnimals
  17. Wang LD, Ficarro SB, Hutchinson JN, Csepanyi-Komi R, Nguyen PT, Wisniewski E, Sullivan J, Hofmann O, Ligeti E, Marto JA, Wagers AJ. Phosphoproteomic profiling of mouse primary HSPCs reveals new regulators of HSPC mobilization. Blood. 2016 09 15; 128(11):1465-74. PMID: 27365422.
    Citations: 1     Fields:    Translation:AnimalsCells
  18. Katagiri S, Park K, Maeda Y, Rao TN, Khamaisi M, Li Q, Yokomizo H, Mima A, Lancerotto L, Wagers A, Orgill DP, King GL. Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance. Diabetes. 2016 09; 65(9):2760-71. PMID: 27217486; PMCID: PMC5001189.
    Citations: 3     Fields:    Translation:AnimalsCells
  19. Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG. EGLN1 Inhibition and Rerouting of a-Ketoglutarate Suffice for Remote Ischemic Protection. Cell. 2016 Apr 07; 165(2):497. PMID: 27058668.
    Citations: 2     Fields:    
  20. Walker RG, Poggioli T, Katsimpardi L, Buchanan SM, Oh J, Wattrus S, Heidecker B, Fong YW, Rubin LL, Ganz P, Thompson TB, Wagers AJ, Lee RT. Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation. Circ Res. 2016 Apr 01; 118(7):1125-41; discussion 1142. PMID: 27034275; PMCID: PMC4818972.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  21. Almada AE, Wagers AJ. Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease. Nat Rev Mol Cell Biol. 2016 05; 17(5):267-79. PMID: 26956195; PMCID: PMC4918817.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  22. Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG. EGLN1 Inhibition and Rerouting of a-Ketoglutarate Suffice for Remote Ischemic Protection. Cell. 2016 Feb 25; 164(5):884-95. PMID: 26919427; PMCID: PMC4819986.
    Citations: 22     Fields:    Translation:Animals
  23. Kuswanto W, Burzyn D, Panduro M, Wang KK, Jang YC, Wagers AJ, Benoist C, Mathis D. Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells. Immunity. 2016 Feb 16; 44(2):355-67. PMID: 26872699; PMCID: PMC4764071.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  24. Khamaisi M, Katagiri S, Keenan H, Park K, Maeda Y, Li Q, Qi W, Thomou T, Eschuk D, Tellechea A, Veves A, Huang C, Orgill DP, Wagers A, King GL. PKCd inhibition normalizes the wound-healing capacity of diabetic human fibroblasts. J Clin Invest. 2016 Mar 01; 126(3):837-53. PMID: 26808499; PMCID: PMC4767341.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  25. Tabebordbar M, Zhu K, Cheng JKW, Chew WL, Widrick JJ, Yan WX, Maesner C, Wu EY, Xiao R, Ran FA, Cong L, Zhang F, Vandenberghe LH, Church GM, Wagers AJ. In vivo gene editing in dystrophic mouse muscle and muscle stem cells. Science. 2016 Jan 22; 351(6271):407-411. PMID: 26721686; PMCID: PMC4924477.
    Citations: 195     Fields:    Translation:AnimalsCells
  26. Hettmer S, Schinzel AC, Tchessalova D, Schneider M, Parker CL, Bronson RT, Richards NG, Hahn WC, Wagers AJ. Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma. Elife. 2015 Oct 24; 4. PMID: 26499495; PMCID: PMC4695385.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  27. Poggioli T, Vujic A, Yang P, Macias-Trevino C, Uygur A, Loffredo FS, Pancoast JR, Cho M, Goldstein J, Tandias RM, Gonzalez E, Walker RG, Thompson TB, Wagers AJ, Fong YW, Lee RT. Circulating Growth Differentiation Factor 11/8 Levels Decline With Age. Circ Res. 2016 Jan 08; 118(1):29-37. PMID: 26489925; PMCID: PMC4748736.
    Citations: 33     Fields:    Translation:Animals
  28. Hettmer S, Lin MM, Tchessalova D, Tortorici SJ, Castiglioni A, Desai T, Mao J, McMahon AP, Wagers AJ. Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity. Exp Cell Res. 2016 Jan 01; 340(1):43-52. PMID: 26460176; PMCID: PMC4718790.
    Citations: 1     Fields:    Translation:Animals
  29. Kowalczyk MS, Tirosh I, Heckl D, Rao TN, Dixit A, Haas BJ, Schneider RK, Wagers AJ, Ebert BL, Regev A. Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells. Genome Res. 2015 Dec; 25(12):1860-72. PMID: 26430063; PMCID: PMC4665007.
    Citations: 49     Fields:    Translation:AnimalsCells
  30. Gupta MK, Teo AK, Rao TN, Bhatt S, Kleinridders A, Shirakawa J, Takatani T, Hu J, De Jesus DF, Windmueller R, Wagers AJ, Kulkarni RN. Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts. Stem Cells Transl Med. 2015 Oct; 4(10):1101-8. PMID: 26253715; PMCID: PMC4572895.
    Citations: 3     Fields:    Translation:HumansCells
  31. Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL, Kulkarni RN. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Cell Metab. 2015 Aug 04; 22(2):239-52. PMID: 26244933; PMCID: PMC4589213.
    Citations: 9     Fields:    Translation:HumansCells
  32. Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Muñoz-Cánoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y. Stem Cells and Aging: What's Next? Cell Stem Cell. 2015 Jun 04; 16(6):578-81. PMID: 26247067.
    Citations:    Fields:    Translation:HumansCells
  33. Castiglioni A, Corna G, Rigamonti E, Basso V, Vezzoli M, Monno A, Almada AE, Mondino A, Wagers AJ, Manfredi AA, Rovere-Querini P. FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration. PLoS One. 2015; 10(6):e0128094. PMID: 26039259; PMCID: PMC4454513.
    Citations: 22     Fields:    Translation:AnimalsCells
  34. Reeves AZ, Spears WE, Du J, Tan KY, Wagers AJ, Lesser CF. Engineering Escherichia coli into a protein delivery system for mammalian cells. ACS Synth Biol. 2015 May 15; 4(5):644-54. PMID: 25853840; PMCID: PMC4487226.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  35. Kim MJ, Miller CM, Shadrach JL, Wagers AJ, Serwold T. Young, proliferative thymic epithelial cells engraft and function in aging thymuses. J Immunol. 2015 May 15; 194(10):4784-95. PMID: 25870244; PMCID: PMC4481326.
    Citations: 8     Fields:    Translation:AnimalsCells
  36. Kolodin D, van Panhuys N, Li C, Magnuson AM, Cipolletta D, Miller CM, Wagers A, Germain RN, Benoist C, Mathis D. Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell Metab. 2015 Apr 07; 21(4):543-57. PMID: 25863247; PMCID: PMC4747251.
    Citations: 59     Fields:    Translation:AnimalsCells
  37. Hettmer S, Teot LA, Kozakewich H, Werger AM, Davies KJ, Fletcher CD, Grier HE, Rodriguez-Galindo C, Wagers AJ. Myogenic tumors in nevoid Basal cell carcinoma syndrome. J Pediatr Hematol Oncol. 2015 Mar; 37(2):147-9. PMID: 24517962; PMCID: PMC4127382.
    Citations: 3     Fields:    Translation:Humans
  38. Hettmer S, Bronson RT, Wagers AJ. Distinct malignant behaviors of mouse myogenic tumors induced by different oncogenetic lesions. Front Oncol. 2015; 5:50. PMID: 25759794; PMCID: PMC4338657.
    Citations: 3     
  39. Rao TN, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN, Serwold T, Pimanda JE, Wagers AJ. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Stem Cell Res. 2015 May; 14(3):307-22. PMID: 25840412; PMCID: PMC4439311.
    Citations: 3     Fields:    Translation:AnimalsCells
  40. Wang LD, Rao TN, Rowe RG, Nguyen PT, Sullivan JL, Pearson DS, Doulatov S, Wu L, Lindsley RC, Zhu H, DeAngelo DJ, Daley GQ, Wagers AJ. The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy. Leukemia. 2015 Jun; 29(6):1320-30. PMID: 25655194; PMCID: PMC4456252.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  41. Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C. Rhabdomyosarcoma: current challenges and their implications for developing therapies. Cold Spring Harb Perspect Med. 2014 Nov 03; 4(11):a025650. PMID: 25368019.
    Citations: 15     Fields:    Translation:Humans
  42. Wagers AJ. How stem cells get "turned on". EMBO J. 2014 Dec 01; 33(23):2743-4. PMID: 25344560; PMCID: PMC4282553.
    Citations:    Fields:    Translation:AnimalsCells
  43. Mostafavi S, Ortiz-Lopez A, Bogue MA, Hattori K, Pop C, Koller D, Mathis D, Benoist C. Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains. J Immunol. 2014 Nov 01; 193(9):4485-96. PMID: 25267973; PMCID: PMC4201955.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  44. Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT. Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning. Blood. 2014 Nov 06; 124(19):2937-47. PMID: 25202142; PMCID: PMC4224192.
    Citations: 9     Fields:    Translation:AnimalsCells
  45. Oh J, Lee YD, Wagers AJ. Stem cell aging: mechanisms, regulators and therapeutic opportunities. Nat Med. 2014 Aug; 20(8):870-80. PMID: 25100532; PMCID: PMC4160113.
    Citations: 92     Fields:    Translation:HumansCells
  46. Tremblay AM, Missiaglia E, Galli GG, Hettmer S, Urcia R, Carrara M, Judson RN, Thway K, Nadal G, Selfe JL, Murray G, Calogero RA, De Bari C, Zammit PS, Delorenzi M, Wagers AJ, Shipley J, Wackerhage H, Camargo FD. The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation. Cancer Cell. 2014 Aug 11; 26(2):273-87. PMID: 25087979.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  47. Painter MW, Brosius Lutz A, Cheng YC, Latremoliere A, Duong K, Miller CM, Posada S, Cobos EJ, Zhang AX, Wagers AJ, Havton LA, Barres B, Omura T, Woolf CJ. Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration. Neuron. 2014 Jul 16; 83(2):331-343. PMID: 25033179; PMCID: PMC4106408.
    Citations: 34     Fields:    Translation:AnimalsCells
  48. Abraham J, Nuñez-Álvarez Y, Hettmer S, Carrió E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansoor A, Chen Y, Suelves M, Rubin BP, Keller C. Lineage of origin in rhabdomyosarcoma informs pharmacological response. Genes Dev. 2014 Jul 15; 28(14):1578-91. PMID: 25030697; PMCID: PMC4102765.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  49. Hung CM, Calejman CM, Sanchez-Gurmaches J, Li H, Clish CB, Hettmer S, Wagers AJ, Guertin DA. Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease. Cell Rep. 2014 Jul 10; 8(1):256-71. PMID: 25001283; PMCID: PMC4096327.
    Citations: 18     Fields:    Translation:AnimalsCells
  50. Sinha I, Sinha-Hikim AP, Wagers AJ, Sinha-Hikim I. Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model. Cell Tissue Res. 2014 Sep; 357(3):815-21. PMID: 24859218; PMCID: PMC4149819.
    Citations: 8     Fields:    Translation:AnimalsCells
  51. Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. 2014 May 09; 344(6184):630-4. PMID: 24797482; PMCID: PMC4123747.
    Citations: 164     Fields:    Translation:AnimalsCells
  52. Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. 2014 May 09; 344(6184):649-52. PMID: 24797481; PMCID: PMC4104429.
    Citations: 181     Fields:    Translation:AnimalsCells
  53. Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim CF. Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis. Cell. 2014 Jan 30; 156(3):440-55. PMID: 24485453.
    Citations: 79     Fields:    Translation:AnimalsCells
  54. Kikuchi K, Hettmer S, Aslam MI, Michalek JE, Laub W, Wilky BA, Loeb DM, Rubin BP, Wagers AJ, Keller C. Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma. PLoS Genet. 2014 Jan; 10(1):e1004107. PMID: 24453992; PMCID: PMC3894165.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  55. Castiglioni A, Hettmer S, Lynes MD, Rao TN, Tchessalova D, Sinha I, Lee BT, Tseng YH, Wagers AJ. Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle. Stem Cell Reports. 2014 Jan 14; 2(1):92-106. PMID: 24678452; PMCID: PMC3966115.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  56. Castiglioni A, Hettmer S, Lynes MD, Rao TN, Tchessalova D, Sinha I, Lee BT, Tseng YH, Wagers AJ. Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle. Stem Cell Reports. 2014 Jan 14; 2(1):92-106. PMID: 28039752.
  57. Hettmer S, Archer NM, Somers GR, Novokmet A, Wagers AJ, Diller L, Rodriguez-Galindo C, Teot LA, Malkin D. Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers. Cancer. 2014 Apr 01; 120(7):1068-75. PMID: 24382691; PMCID: PMC4173134.
    Citations: 8     Fields:    Translation:Humans
  58. Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, Sefik E, Tan TG, Wagers AJ, Benoist C, Mathis D. A special population of regulatory T cells potentiates muscle repair. Cell. 2013 Dec 05; 155(6):1282-95. PMID: 24315098; PMCID: PMC3894749.
    Citations: 210     Fields:    Translation:AnimalsCells
  59. Xu C, Tabebordbar M, Iovino S, Ciarlo C, Liu J, Castiglioni A, Price E, Liu M, Barton ER, Kahn CR, Wagers AJ, Zon LI. A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species. Cell. 2013 Nov 07; 155(4):909-921. PMID: 24209627; PMCID: PMC3902670.
    Citations: 53     Fields:    Translation:AnimalsCells
  60. Teo AK, Wagers AJ, Kulkarni RN. New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism. Cell Metab. 2013 Dec 03; 18(6):775-91. PMID: 24035588; PMCID: PMC3858409.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  61. Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol. 2013 Oct; 31(10):898-907. PMID: 24013197; PMCID: PMC4058317.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  62. Hettmer S, Teot LA, van Hummelen P, MacConaill L, Bronson RT, Dall'Osso C, Mao J, McMahon AP, Gruber PJ, Grier HE, Rodriguez-Galindo C, Fletcher CD, Wagers AJ. Mutations in Hedgehog pathway genes in fetal rhabdomyomas. J Pathol. 2013 Sep; 231(1):44-52. PMID: 23780909; PMCID: PMC3875333.
    Citations: 11     Fields:    Translation:HumansAnimals
  63. Gazit R, Garrison BS, Rao TN, Shay T, Costello J, Ericson J, Kim F, Collins JJ, Regev A, Wagers AJ, Rossi DJ. Transcriptome analysis identifies regulators of hematopoietic stem and progenitor cells. Stem Cell Reports. 2013; 1(3):266-80. PMID: 24319662; PMCID: PMC3849420.
    Citations: 39     Fields:    Translation:Cells
  64. Aslam MI, Hettmer S, Abraham J, Latocha D, Soundararajan A, Huang ET, Goros MW, Michalek JE, Wang S, Mansoor A, Druker BJ, Wagers AJ, Tyner JW, Keller C. Dynamic and nuclear expression of PDGFRa and IGF-1R in alveolar Rhabdomyosarcoma. Mol Cancer Res. 2013 Nov; 11(11):1303-13. PMID: 23928059; PMCID: PMC3834004.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  65. Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, van Wijngaarden P, Wagers AJ, Williams A, Franklin RJM, Ffrench-Constant C. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci. 2013 Sep; 16(9):1211-1218. PMID: 23872599.
    Citations: 280     Fields:    Translation:HumansAnimalsCells
  66. Schepers K, Pietras EM, Reynaud D, Flach J, Binnewies M, Garg T, Wagers AJ, Hsiao EC, Passegué E. Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell. 2013 Sep 05; 13(3):285-99. PMID: 23850243; PMCID: PMC3769504.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  67. Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013 May 09; 153(4):828-39. PMID: 23663781; PMCID: PMC3677132.
    Citations: 190     Fields:    Translation:HumansAnimalsCells
  68. Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Nageswara Rao T, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S. The transcriptional landscape of aß T cell differentiation. Nat Immunol. 2013 Jun; 14(6):619-32. PMID: 23644507; PMCID: PMC3660436.
    Citations: 77     Fields:    Translation:AnimalsCells
  69. Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemarte-Pelletier A, Malhotra D, Turley S. Identification of transcriptional regulators in the mouse immune system. Nat Immunol. 2013 Jun; 14(6):633-43. PMID: 23624555; PMCID: PMC3690947.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  70. Le X, Pugach EK, Hettmer S, Storer NY, Liu J, Wills AA, DiBiase A, Chen EY, Ignatius MS, Poss KD, Wagers AJ, Langenau DM, Zon LI. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Development. 2013 Jun; 140(11):2354-64. PMID: 23615277.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  71. Nabors LK, Wang LD, Wagers AJ, Kansas GS. Overlapping roles for endothelial selectins in murine hematopoietic stem/progenitor cell homing to bone marrow. Exp Hematol. 2013 Jul; 41(7):588-96. PMID: 23499761.
    Citations: 4     Fields:    Translation:AnimalsCells
  72. Best JA, Blair DA, Knell J, Yang E, Mayya V, Doedens A, Dustin ML, Goldrath AW. Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nat Immunol. 2013 Apr; 14(4):404-12. PMID: 23396170; PMCID: PMC3689652.
    Citations: 85     Fields:    Translation:AnimalsCells
  73. El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN. Liver-derived systemic factors drive ß cell hyperplasia in insulin-resistant states. Cell Rep. 2013 Feb 21; 3(2):401-10. PMID: 23375376.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  74. Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB. Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nat Immunol. 2013 Jan; 14(1):90-9. PMID: 23202270; PMCID: PMC3764492.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  75. Tabebordbar M, Wang ET, Wagers AJ. Skeletal muscle degenerative diseases and strategies for therapeutic muscle repair. Annu Rev Pathol. 2013 Jan 24; 8:441-75. PMID: 23121053.
    Citations: 13     Fields:    Translation:HumansAnimals
  76. Liu J, Hettmer S, Milsom MD, Hofmann I, Hua F, Miller C, Bronson RT, Wagers AJ. Induction of histiocytic sarcoma in mouse skeletal muscle. PLoS One. 2012; 7(8):e44044. PMID: 22952867; PMCID: PMC3432091.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  77. Hayhurst M, Wagner AK, Cerletti M, Wagers AJ, Rubin LL. A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein. Dev Biol. 2012 Aug 15; 368(2):323-34. PMID: 22705478; PMCID: PMC3851302.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  78. Gottumukkala RV, Lv H, Cornivelli L, Wagers AJ, Kwong RY, Bronson R, Stewart GC, Schulze PC, Chutkow W, Wolpert HA, Lee RT, Lipes MA. Myocardial infarction triggers chronic cardiac autoimmunity in type 1 diabetes. Sci Transl Med. 2012 Jun 13; 4(138):138ra80. PMID: 22700956; PMCID: PMC4303259.
    Citations: 8     Fields:    Translation:Animals
  79. Cerletti M, Jang YC, Finley LW, Haigis MC, Wagers AJ. Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell. 2012 May 04; 10(5):515-9. PMID: 22560075; PMCID: PMC3561899.
    Citations: 81     Fields:    Translation:AnimalsCells
  80. Wagers AJ. The stem cell niche in regenerative medicine. Cell Stem Cell. 2012 Apr 06; 10(4):362-9. PMID: 22482502.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  81. Jiang X, Clark RA, Liu L, Wagers AJ, Fuhlbrigge RC, Kupper TS. Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature. 2012 Feb 29; 483(7388):227-31. PMID: 22388819; PMCID: PMC3437663.
    Citations: 227     Fields:    Translation:AnimalsCells
  82. Gibney BC, Chamoto K, Lee GS, Simpson DC, Miele LF, Tsuda A, Konerding MA, Wagers A, Mentzer SJ. Cross-circulation and cell distribution kinetics in parabiotic mice. J Cell Physiol. 2012 Feb; 227(2):821-8. PMID: 21503883; PMCID: PMC3160515.
    Citations: 14     Fields:    Translation:AnimalsCells
  83. Ruckh JM, Zhao JW, Shadrach JL, van Wijngaarden P, Rao TN, Wagers AJ, Franklin RJ. Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell. 2012 Jan 06; 10(1):96-103. PMID: 22226359.
    Citations: 144     Fields:    Translation:AnimalsCells
  84. Hettmer S, Liu J, Miller CM, Lindsay MC, Sparks CA, Guertin DA, Bronson RT, Langenau DM, Wagers AJ. Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20002-7. PMID: 22135462; PMCID: PMC3250188.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  85. Tan KY, Eminli S, Hettmer S, Hochedlinger K, Wagers AJ. Efficient generation of iPS cells from skeletal muscle stem cells. PLoS One. 2011; 6(10):e26406. PMID: 22028872; PMCID: PMC3196574.
    Citations: 20     Fields:    Translation:AnimalsCells
  86. Jang YC, Sinha M, Cerletti M, Dall'Osso C, Wagers AJ. Skeletal muscle stem cells: effects of aging and metabolism on muscle regenerative function. Cold Spring Harb Symp Quant Biol. 2011; 76:101-11. PMID: 21960527.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  87. Wang LD, Wagers AJ. Dynamic niches in the origination and differentiation of haematopoietic stem cells. Nat Rev Mol Cell Biol. 2011 Sep 02; 12(10):643-55. PMID: 21886187; PMCID: PMC4040463.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  88. Shadrach JL, Wagers AJ. Stem cells for skeletal muscle repair. Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12; 366(1575):2297-306. PMID: 21727135; PMCID: PMC3130421.
    Citations: 22     Fields:    Translation:HumansCells
  89. Hettmer S, Liu J, Miller CM, Bronson RT, Langenau DM, Wagers AJ. Use of cellular context to determine sarcoma phenotype in a new mouse sarcoma model. J Clin Oncol. 2011 May 20; 29(15_suppl):10029. PMID: 28021101.
  90. Woo M, Isganaitis E, Cerletti M, Fitzpatrick C, Wagers AJ, Jimenez-Chillaron J, Patti ME. Early life nutrition modulates muscle stem cell number: implications for muscle mass and repair. Stem Cells Dev. 2011 Oct; 20(10):1763-9. PMID: 21247245; PMCID: PMC3182031.
    Citations: 27     Fields:    Translation:AnimalsCells
  91. Schulz TJ, Huang TL, Tran TT, Zhang H, Townsend KL, Shadrach JL, Cerletti M, McDougall LE, Giorgadze N, Tchkonia T, Schrier D, Falb D, Kirkland JL, Wagers AJ, Tseng YH. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):143-8. PMID: 21173238; PMCID: PMC3017184.
    Citations: 174     Fields:    Translation:HumansAnimalsCells
  92. Wagers A. Delivering on a promise. Interviewed by Kristie Nybo. Biotechniques. 2010 Aug; 49(2):545. PMID: 20945585.
    Citations:    Fields:    Translation:HumansAnimalsCells
  93. Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, Tan KY, Apostolou E, Stadtfeld M, Li Y, Shioda T, Natesan S, Wagers AJ, Melnick A, Evans T, Hochedlinger K. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol. 2010 Aug; 28(8):848-55. PMID: 20644536; PMCID: PMC3148605.
    Citations: 448     Fields:    Translation:AnimalsCells
  94. Young AP, Wagers AJ. Pax3 induces differentiation of juvenile skeletal muscle stem cells without transcriptional upregulation of canonical myogenic regulatory factors. J Cell Sci. 2010 Aug 01; 123(Pt 15):2632-9. PMID: 20605921; PMCID: PMC2908050.
    Citations: 14     Fields:    Translation:HumansCells
  95. Taylor PL, Barker RA, Blume KG, Cattaneo E, Colman A, Deng H, Edgar H, Fox IJ, Gerstle C, Goldstein LS, High KA, Lyall A, Parkman R, Pitossi FJ, Prentice ED, Rooke HM, Sipp DA, Srivastava A, Stayn S, Steinberg GK, Wagers AJ, Weissman IL. Patients beware: commercialized stem cell treatments on the web. Cell Stem Cell. 2010 Jul 02; 7(1):43-9. PMID: 20621049.
    Citations: 13     Fields:    Translation:HumansCells
  96. Song G, Nguyen DT, Pietramaggiori G, Scherer S, Chen B, Zhan Q, Ogawa R, Yannas IV, Wagers AJ, Orgill DP, Murphy GF. Use of the parabiotic model in studies of cutaneous wound healing to define the participation of circulating cells. Wound Repair Regen. 2010 Jul-Aug; 18(4):426-32. PMID: 20546556; PMCID: PMC2935287.
    Citations: 11     Fields:    Translation:AnimalsCells
  97. Rask-Madsen C, Li Q, Freund B, Feather D, Abramov R, Wu IH, Chen K, Yamamoto-Hiraoka J, Goldenbogen J, Sotiropoulos KB, Clermont A, Geraldes P, Dall'Osso C, Wagers AJ, Huang PL, Rekhter M, Scalia R, Kahn CR, King GL. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab. 2010 May 05; 11(5):379-89. PMID: 20444418; PMCID: PMC3020149.
    Citations: 93     Fields:    Translation:AnimalsCells
  98. Hettmer S, Wagers AJ. Muscling in: Uncovering the origins of rhabdomyosarcoma. Nat Med. 2010 Feb; 16(2):171-3. PMID: 20134473.
    Citations: 36     Fields:    Translation:HumansAnimals
  99. Mayack SR, Shadrach JL, Kim FS, Wagers AJ. Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Nature. 2010 Jan 28; 463(7280):495-500. PMID: 20110993.
    Citations: 41     Fields:    Translation:AnimalsCells
  100. Forsberg EC, Passegué E, Prohaska SS, Wagers AJ, Koeva M, Stuart JM, Weissman IL. Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells. PLoS One. 2010 Jan 20; 5(1):e8785. PMID: 20098702; PMCID: PMC2808351.
    Citations: 44     Fields:    Translation:AnimalsCells
  101. Schemionek M, Elling C, Steidl U, Bäumer N, Hamilton A, Spieker T, Göthert JR, Stehling M, Wagers A, Huettner CS, Tenen DG, Tickenbrock L, Berdel WE, Serve H, Holyoake TL, Müller-Tidow C, Koschmieder S. BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells. Blood. 2010 Apr 22; 115(16):3185-95. PMID: 20053753; PMCID: PMC2858483.
    Citations: 44     Fields:    Translation:AnimalsCells
  102. Conboy MJ, Cerletti M, Wagers AJ, Conboy IM. Immuno-analysis and FACS sorting of adult muscle fiber-associated stem/precursor cells. Methods Mol Biol. 2010; 621:165-73. PMID: 20405366.
    Citations: 25     Fields:    Translation:AnimalsCells
  103. Liu J, Sato C, Cerletti M, Wagers A. Notch signaling in the regulation of stem cell self-renewal and differentiation. Curr Top Dev Biol. 2010; 92:367-409. PMID: 20816402.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  104. Guibal FC, Alberich-Jorda M, Hirai H, Ebralidze A, Levantini E, Di Ruscio A, Zhang P, Santana-Lemos BA, Neuberg D, Wagers AJ, Rego EM, Tenen DG. Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia. Blood. 2009 Dec 24; 114(27):5415-25. PMID: 19797526; PMCID: PMC2798860.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  105. Kumar D, Shadrach JL, Wagers AJ, Lassar AB. Id3 is a direct transcriptional target of Pax7 in quiescent satellite cells. Mol Biol Cell. 2009 Jul; 20(14):3170-7. PMID: 19458195.
    Citations: 35     Fields:    Translation:AnimalsCells
  106. Pietramaggiori G, Scherer SS, Alperovich M, Chen B, Orgill DP, Wagers AJ. Improved cutaneous healing in diabetic mice exposed to healthy peripheral circulation. J Invest Dermatol. 2009 Sep; 129(9):2265-74. PMID: 19295612.
    Citations: 18     Fields:    Translation:Animals
  107. Cerletti M, Shadrach JL, Jurga S, Sherwood R, Wagers AJ. Regulation and function of skeletal muscle stem cells. Cold Spring Harb Symp Quant Biol. 2008; 73:317-22. PMID: 19204065.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  108. Breault DT, Min IM, Carlone DL, Farilla LG, Ambruzs DM, Henderson DE, Algra S, Montgomery RK, Wagers AJ, Hole N. Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10420-5. PMID: 18650388; PMCID: PMC2492454.
    Citations: 47     Fields:    Translation:AnimalsCells
  109. Cerletti M, Jurga S, Witczak CA, Hirshman MF, Shadrach JL, Goodyear LJ, Wagers AJ. Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles. Cell. 2008 Jul 11; 134(1):37-47. PMID: 18614009; PMCID: PMC3665268.
    Citations: 174     Fields:    Translation:HumansAnimalsCells
  110. Cao YA, Wagers AJ, Karsunky H, Zhao H, Reeves R, Wong RJ, Stevenson DK, Weissman IL, Contag CH. Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors. Blood. 2008 Dec 01; 112(12):4494-502. PMID: 18509090; PMCID: PMC2597124.
    Citations: 18     Fields:    Translation:AnimalsCells
  111. Mayack SR, Wagers AJ. Osteolineage niche cells initiate hematopoietic stem cell mobilization. Blood. 2008 Aug 01; 112(3):519-31. PMID: 18456874; PMCID: PMC2481533.
    Citations: 38     Fields:    Translation:AnimalsCells
  112. Min IM, Pietramaggiori G, Kim FS, Passegué E, Stevenson KE, Wagers AJ. The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells. Cell Stem Cell. 2008 Apr 10; 2(4):380-91. PMID: 18397757.
    Citations: 85     Fields:    Translation:AnimalsCells
  113. Jakubzick C, Tacke F, Ginhoux F, Wagers AJ, van Rooijen N, Mack M, Merad M, Randolph GJ. Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations. J Immunol. 2008 Mar 01; 180(5):3019-27. PMID: 18292524.
    Citations: 99     Fields:    Translation:AnimalsCells
  114. Laird DJ, von Andrian UH, Wagers AJ. Stem cell trafficking in tissue development, growth, and disease. Cell. 2008 Feb 22; 132(4):612-30. PMID: 18295579.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  115. Wagers AJ. Wnt not, waste not. Cell Stem Cell. 2008 Jan 10; 2(1):6-7. PMID: 18371413.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  116. Jones DL, Wagers AJ. No place like home: anatomy and function of the stem cell niche. Nat Rev Mol Cell Biol. 2008 Jan; 9(1):11-21. PMID: 18097443.
    Citations: 188     Fields:    Translation:HumansAnimalsCells
  117. Massberg S, Schaerli P, Knezevic-Maramica I, Köllnberger M, Tubo N, Moseman EA, Huff IV, Junt T, Wagers AJ, Mazo IB, von Andrian UH. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell. 2007 Nov 30; 131(5):994-1008. PMID: 18045540; PMCID: PMC2330270.
    Citations: 260     Fields:    Translation:AnimalsCells
  118. Monach PA, Verschoor A, Jacobs JP, Carroll MC, Wagers AJ, Benoist C, Mathis D. Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model. Arthritis Rheum. 2007 Sep; 56(9):2968-74. PMID: 17763447; PMCID: PMC2559465.
    Citations: 10     Fields:    Translation:Animals
  119. Sherwood RI, Wagers AJ, Weissman IL. Isolation and characterization of muscle regenerating cells(pending). 2007.
  120. Monach PA, Verschoor A, Jacobs JP, Carroll MC, Wagers AJ, Benoist C, Mathis D. Circulating C3 is necessary and sufficient for autoantibody-mediated arthritis. Arthritis & Rheumatism. 2007.
  121. Wagers AJ, Min IM. Enhancing stem cell mobilization (pending). 2007.
  122. Bogunovic M, Ginhoux F, Wagers A, Loubeau M, Isola LM, Lubrano L, Najfeld V, Phelps RG, Grosskreutz C, Scigliano E, Frenette PS, Merad M. Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men. J Exp Med. 2006 Nov 27; 203(12):2627-38. PMID: 17116734; PMCID: PMC2118165.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  123. Santarelli JG, Udani V, Yung YC, Cheshier S, Wagers A, Brekken RA, Weissman I, Tse V. Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain. Neurosurgery. 2006 Aug; 59(2):374-82; discussion 374-82. PMID: 16883178.
    Citations: 17     Fields:    Translation:AnimalsCells
  124. Wagers, AJ. Podcast Special: Stem Cells. 2006.
  125. Eggan K, Jurga S, Gosden R, Min IM, Wagers AJ. Ovulated oocytes in adult mice derive from non-circulating germ cells. Nature. 2006 Jun 29; 441(7097):1109-14. PMID: 16799565.
    Citations: 61     Fields:    Translation:AnimalsCells
  126. Sherwood RI, Wagers AJ. Harnessing the potential of myogenic satellite cells. Trends Mol Med. 2006 May; 12(5):189-92. PMID: 16595190.
    Citations: 2     Fields:    Translation:AnimalsCells
  127. Passegué E, Wagers AJ. Regulating quiescence: new insights into hematopoietic stem cell biology. Dev Cell. 2006 Apr; 10(4):415-7. PMID: 16580989.
    Citations: 11     Fields:    Translation:AnimalsCells
  128. Bogunovic M, Ginhoux F, Wagers A, Loubeau M, Isola LM, Lubrano L, Najfeld V, Phelps RG, Grosskreutz C, Scigliano E, Frenette P, Merad M. Identification of a cycling and radio-resistant dendritic cell population in mouse and human dermis: potential impact on graft versus host disease. Journal of Experimental Medicine. 2006; 203:2627-38.
  129. Wagers AJ, Weissman IL. Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cells. Stem Cells. 2006 Apr; 24(4):1087-94. PMID: 16373693.
    Citations: 14     Fields:    Translation:AnimalsCells
  130. Passegué E, Wagers AJ, Giuriato S, Anderson WC, Weissman IL. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med. 2005 Dec 05; 202(11):1599-611. PMID: 16330818; PMCID: PMC2213324.
    Citations: 240     Fields:    Translation:HumansAnimalsCells
  131. Udani VM, Santarelli JG, Yung YC, Wagers AJ, Cheshier SH, Weissman IL, Tse V. Hematopoietic stem cells give rise to perivascular endothelial-like cells during brain tumor angiogenesis. Stem Cells Dev. 2005 Oct; 14(5):478-86. PMID: 16305333.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  132. Wagers AJ, Conboy IM. Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis. Cell. 2005 Sep 09; 122(5):659-67. PMID: 16143100.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  133. Surdez D, Kunz B, Wagers AJ, Weissman IL, Terskikh AV. Simple and efficient isolation of hematopoietic stem cells from H2K-zFP transgenic mice. Stem Cells. 2005 Nov-Dec; 23(10):1617-25. PMID: 16091556.
    Citations: 1     Fields:    Translation:AnimalsCells
  134. Wagers AJ. Stem cell grand SLAM. Cell. 2005 Jul 01; 121(7):967-70. PMID: 15989946.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  135. Rossi DJ, Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ, Weissman IL. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9194-9. PMID: 15967997; PMCID: PMC1153718.
    Citations: 296     Fields:    Translation:AnimalsCells
  136. Massengale M, Wagers AJ, Vogel H, Weissman IL. Hematopoietic cells maintain hematopoietic fates upon entering the brain. J Exp Med. 2005 May 16; 201(10):1579-89. PMID: 15897275; PMCID: PMC2212913.
    Citations: 35     Fields:    Translation:AnimalsCells
  137. Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005 Feb 17; 433(7027):760-4. PMID: 15716955.
    Citations: 596     Fields:    Translation:AnimalsCells
  138. Santarelli JG, Udani V, Yung CY, Cheshier S, Wagers A, Brekken RA, Weissman I, Tse V. Preuss Resident Research Award: bone marrow-derived Flk-1-expressing CD34+ cells contribute to the endothelium of tumor vessels in mouse brain. Clin Neurosurg. 2005; 52:384-8. PMID: 16626098.
    Citations: 2     Fields:    Translation:HumansAnimals
  139. Rossi DJ, Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ, Weissman IL. Cell intrinsic alterations underlie hematopoietic stem cells aging. Proceeding of the National Academy of Science USA. 2005; 102:9194-99.
  140. Domen J, Wagers A, Weissman IL. Hematopoietic stem cells. In Stem Cells: Scientific Progress and Future Research Directions. Department of Health and Human Services. 2005.
  141. Yung YC, Cheshier S, Santarelli JG, Huang Z, Wagers A, Weissman I, Tse V. Incorporation of naive bone marrow derived cells into the vascular architecture of brain tumor. Microcirculation. 2004 Dec; 11(8):699-708. PMID: 15726837.
    Citations: 1     Fields:    Translation:AnimalsCells
  142. Sherwood RI, Christensen JL, Conboy IM, Conboy MJ, Rando TA, Weissman IL, Wagers AJ. Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. Cell. 2004 Nov 12; 119(4):543-54. PMID: 15537543.
    Citations: 170     Fields:    Translation:AnimalsCells
  143. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature. 2004 Apr 08; 428(6983):668-73. PMID: 15034594.
    Citations: 384     Fields:    Translation:AnimalsCells
  144. Christensen JL, Wright DE, Wagers AJ, Weissman IL. Circulation and chemotaxis of fetal hematopoietic stem cells. PLoS Biol. 2004 Mar; 2(3):E75. PMID: 15024423; PMCID: PMC368169.
    Citations: 69     Fields:    Translation:AnimalsCells
  145. Wagers AJ, Weissman IL. Plasticity of adult stem cells. Cell. 2004 Mar 05; 116(5):639-48. PMID: 15006347.
    Citations: 229     Fields:    Translation:HumansAnimalsCells
  146. Sherwood RI, Christensen JL, Weissman IL, Wagers AJ. Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cells. Stem Cells. 2004; 22(7):1292-304. PMID: 15579647.
    Citations: 21     Fields:    Translation:AnimalsCells
  147. Yung Y, Cheshier S, Santarelli JG, Huang Z, Wagers AJ, Weissman IL, Tse V. Incorporation of naïve bone marrow derived cells into the vascular architecture of brain tumor. Microcirculation 2004. 2004; 11:699-708.
  148. Cao Y*, Wagers AJ*, Beilhack A, Dusich J, Bachmann MH, Negrin RS, Weissman IL, Contag CH *Equal contributors. Shifting Foci of Hematopoiesis during Reconstitution by Single Stem Cells. Proceedings of the National Academy of Science USA. 2004; 101:221-6.
  149. Christensen JL, Wright DE, Wagers AJ, Weissman IL. Constitutive circulation of HSC in fetal blood. PLoS Biology. 2004; 2:368-77.
  150. Cao YA, Wagers AJ, Beilhack A, Dusich J, Bachmann MH, Negrin RS, Weissman IL, Contag CH. Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):221-6. PMID: 14688412; PMCID: PMC314166.
    Citations: 126     Fields:    Translation:AnimalsCells
  151. Kondo M, Wagers AJ, Manz MG, Prohaska SS, Scherer DC, Beilhack GF, Shizuru JA, Weissman IL. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol. 2003; 21:759-806. PMID: 12615892.
    Citations: 264     Fields:    Translation:HumansAnimalsCells
  152. Merad M, Manz MG, Karsunky H, Wagers A, Peters W, Charo I, Weissman IL, Cyster JG, Engleman EG. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol. 2002 Dec; 3(12):1135-41. PMID: 12415265; PMCID: PMC4727838.
    Citations: 249     Fields:    Translation:AnimalsCells
  153. Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science. 2002 Sep 27; 297(5590):2256-9. PMID: 12215650.
    Citations: 309     Fields:    Translation:AnimalsCells
  154. Wright DE, Bowman EP, Wagers AJ, Butcher EC, Weissman IL. Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med. 2002 May 06; 195(9):1145-54. PMID: 11994419; PMCID: PMC2193709.
    Citations: 122     Fields:    Translation:AnimalsCells
  155. Wagers AJ, Christensen JL, Weissman IL. Cell fate determination from stem cells. Gene Ther. 2002 May; 9(10):606-12. PMID: 12032706.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  156. Wagers AJ, Allsopp RC, Weissman IL. Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor. Exp Hematol. 2002 Feb; 30(2):176-85. PMID: 11823053.
    Citations: 31     Fields:    Translation:AnimalsCells
  157. Wright DE, Bowman EP, Wagers AJ, Butcher EC, Weissman IL. Highly enriched hematopoietic stem cells are uniquely selective in their migratory response to chemokines. Journal of Experimental Medicine. 2002; 195:1145-54.
  158. Wagers AJ, Allsopp RA, Weissman, IL. Changes in integrin expression are associated with altered homing properties of hematopoietic stem cells following mobilization by cyclophosphamide/ granulocyte colony-stimulating factor. Experimantal Hematology. 2002; (30):176-85.
  159. Wright DE, Wagers AJ, Gulati AP, Johnson FL, Weissman IL. Physiological migration of hematopoietic stem and progenitor cells. Science. 2001 Nov 30; 294(5548):1933-6. PMID: 11729320.
    Citations: 265     Fields:    Translation:AnimalsCells
  160. Wright DE, Cheshier SH, Wagers AJ, Randall TD, Christensen JL, Weissman IL. Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Blood. 2001 Apr 15; 97(8):2278-85. PMID: 11290588.
    Citations: 67     Fields:    Translation:AnimalsCells
  161. Wagers AJ, Kansas GS. Potent induction of alpha(1,3)-fucosyltransferase VII in activated CD4+ T cells by TGF-beta 1 through a p38 mitogen-activated protein kinase-dependent pathway. J Immunol. 2000 Nov 01; 165(9):5011-6. PMID: 11046029.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  162. Wagers AJ, Kansas GS. Potent induction of FucT-VII in activated CD4+ T cells by TGF-b1 through a p38 MAP kinase-dependent pathway. Journal of Immunology. 2000; 165:5011-6.
  163. Lim YC, Henault L, Wagers AJ, Kansas GS, Luscinskas FW, Lichtman AH. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J Immunol. 1999 Mar 15; 162(6):3193-201. PMID: 10092770.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  164. Lim YC, Henault L, Wagers AJ, Kansas GS, Luscinskas FW, Lichtman AH. Expression of functional selectin ligands on helper T cells is differentially regulated by interleukin-12 and interleukin-4. Journal of Immunology. 1999; 162:3193-201.
  165. Wagers AJ. Regulation of alpha(1,3)-fucosyltransferase expression controls leukocyte adhesion to vascular selectins [dissertation]. 1999.
  166. Wagers AJ, Waters CM, Stoolman LM, Kansas GS. Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on alpha1, 3-fucosyltransferase VII gene expression. J Exp Med. 1998 Dec 21; 188(12):2225-31. PMID: 9858509; PMCID: PMC2212430.
    Citations: 38     Fields:    Translation:HumansCells
  167. Wagers AJ, Stoolman LM, Craig R, Knibbs RN, Kansas GS. An sLex-deficient variant of HL60 cells exhibits high levels of adhesion to vascular selectins: further evidence that HECA-452 and CSLEX1 monoclonal antibody epitopes are not essential for high avidity binding to vascular selectins. J Immunol. 1998 May 15; 160(10):5122-9. PMID: 9590264.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  168. Wagers AJ, Waters CM, Stoolman LM, Kansas GS. IL-12 and IL-4 control T cell adhesion to endothelial selectins through opposite effects on FucT-VII gene expression. Journal of Experimental Medicine. 1998; 188:2225-31.
  169. Wagers AJ, Stoolman LM, Craig R, Knibbs RN, Kansas GS. An sLex-deficient variant of HL60 Cells exhibits high levels of adhesion to vascular selectins: further evidence that HECA-452 and CSLEX1 monoclonal antibody epitopes are not essential for high avidity binding to vascular selectins. Journal of Immunology. 1998; 160:3193-201.
  170. Wagers AJ, Stoolman LM, Kannagi R, Craig R, Kansas GS. Expression of leukocyte fucosyltransferases regulates binding to E-selectin: relationship to previously implicated carbohydrate epitopes. J Immunol. 1997 Aug 15; 159(4):1917-29. PMID: 9257857.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  171. Snapp KR, Wagers AJ, Craig R, Stoolman LM, Kansas GS. P-selectin glycoprotein ligand-1 is essential for adhesion to P-selectin but not E-selectin in stably transfected hematopoietic cell lines. Blood. 1997 Feb 01; 89(3):896-901. PMID: 9028320.
    Citations: 19     Fields:    Translation:HumansCells
  172. Wagers AJ, Craig R, Kannagi R, Stoolman LM, Kansas GS. Expression of leukocyte fucosyltransferases regulates binding to E-selectin: relationship to previously implicated carbohydrate epitopes. Journal of Immunology. 1997; 159:1917-29.
  173. Wagers AJ, Lowe JB, Kansas GS. An important role for the alpha 1,3 fucosyltransferase, FucT-VII, in leukocyte adhesion to E-selectin. Blood. 1996 Sep 15; 88(6):2125-32. PMID: 8822932.
    Citations: 23     Fields:    Translation:HumansCells
  174. BRECKENRIDGE RL, WAGERS AJ, BALTZELL WH. Lethal granuloma of the midline facial tissues; granuloma gangraenescens. Ann Otol Rhinol Laryngol. 1954 Jun; 63(2):278-95. PMID: 13189300.
    Citations: 2     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.