Harvard Catalyst Profiles

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Heena Kumra, Ph.D.

Title
Institution
Department
Address

Biography
education and training
University of Delhi, Delhi, IndiaBSc05/2009Biomedical Sciences
University of Delhi, Delhi, IndiaMSc05/2011Plant Molecular Biology and Biotechnology
McGill University, Montreal, CanadaPhD05/2019Cell Biology, vascular biology and extracellular matrix biology
Massachusetts General Hospital/Harvard Medical School, Boston, MA, USAPostdoctoral Research FellowongoingTumor microenvironment
awards and honors
2008
Summer Research Fellowship
2009 - 2010
Rotary Postgraduate Scholarship
2010 - 2011
Postgraduate Monsanto Scholarship
2011 - 2012
Junior Research Fellowship
2013
Graduate Student Excellence Recruitment Award
2013
Differential Fee Waiver
2013
Student Conference Support
2014
Graduate Research Enhancement and Travel Award
2014
Poster Prize
2014
Differential Fee Waiver
2015
Graduate Research Enhancement and Travel Award
2015 - 2015
Doctoral research scholarship for foreign student
2015
Oral presentation award
2015
Student Conference Support
2015
Travel Award
2016
Oral presentation award
2016
Travel award
2016
Best oral presentation award
2016
International travel grant
2016
Student Conference Support
2016
Graduate Research Enhancement and Travel Award
2017
CIHR Honorable Mention Award
2017
CIHR travel award for CIHR National Research Poster Competition
2017
Best oral presentation
2017
Best poster presentation
2017
Travel Award
2017
Graduate Research Enhancement and Travel Award
2017
Student Conference Support
2018
Travel Award
2019
Travel Award
2019
Registration Support
2020
Founders Award

Overview
overview
I am currently a postdoctoral fellow in the lab of Dr. Rakesh K Jain. The overarching goal of my postdoctoral project is to improve immunotherapy of pancreatic ductal adenocarcinoma (PDAC) by understanding the molecular and cellular mechanisms that fuel PDAC progression and treatment-resistance. I have my expertise developed over 7 years during my doctoral and postdoctoral research (01/2013 - 03/2020) in the field of extracellular matrix biology and vascular biology at McGill University, and almost 2 years of postdoctoral research in pancreatic cancer biology (07/2020 -) in the Steele Laboratories.
keywords
webpage

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Boucher Y, Posada JM, Subudhi S, Kumar AS, Rosario SR, Gu L, Kumra H, Mino-Kenudson M, Talele NP, Duda DG, Fukumura D, Wo JY, Clark JW, Ryan DP, Fernandez-Del Castillo C, Hong TS, Pittet MJ, Jain RK. Addition of losartan to FOLFIRINOX and chemoradiation reduces immunosuppression-associated genes, Tregs and FOXP3+ cancer cells in locally advanced pancreatic cancer. Clin Cancer Res. 2023 Feb 07. PMID: 36749873.
    Citations:    Fields:    
  2. Shi Y, Jones W, Beatty W, Tan Q, Mecham RP, Kumra H, Reinhardt DP, Gibson MA, Reilly MA, Rodriguez J, Bassnett S. Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers. Matrix Biol. 2021 01; 95:15-31. PMID: 33039488.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  3. Zeyer KA, Zhang RM, Kumra H, Hassan A, Reinhardt DP. Corrigendum to "The Fibrillin-1 RGD Integrin Binding Site Regulates Gene Expression and Cell Function Through microRNAs" [J. Mol. Biol. 431 (2) (2019) 401-421]. J Mol Biol. 2020 Feb 14; 432(4):1306. PMID: 31917007.
    Citations:    Fields:    
  4. Zhang RM, Kumra H, Reinhardt DP. Quantification of Extracellular Matrix Fiber Systems Related to ADAMTS Proteins. Methods Mol Biol. 2020; 2043:237-250. PMID: 31463916.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  5. Kumra H, Nelea V, Hakami H, Pagliuzza A, Djokic J, Xu J, Yanagisawa H, Reinhardt DP. Fibulin-4 exerts a dual role in LTBP-4L-mediated matrix assembly and function. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20428-20437. PMID: 31548410.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  6. Kumra H, Dinesh NEH, Reinhardt DP. Lessons from tracheal tube development for understanding congenital tracheal malformations. Eur Respir J. 2019 03; 53(3). PMID: 30846450.
    Citations:    Fields:    Translation:AnimalsCells
  7. Burger J, van Vliet N, van Heijningen P, Kumra H, Kremers GJ, Alves M, van Cappellen G, Yanagisawa H, Reinhardt DP, Kanaar R, van der Pluijm I, Essers J. Fibulin-4 deficiency differentially affects cytoskeleton structure and dynamics as well as TGFß signaling. Cell Signal. 2019 06; 58:65-78. PMID: 30844428.
    Citations: 6     Fields:    Translation:AnimalsCells
  8. Zeyer KA, Zhang RM, Kumra H, Hassan A, Reinhardt DP. The Fibrillin-1 RGD Integrin Binding Site Regulates Gene Expression and Cell Function through microRNAs. J Mol Biol. 2019 01 18; 431(2):401-421. PMID: 30500337.
    Citations: 3     Fields:    Translation:HumansCells
  9. Kumra H, Sabatier L, Hassan A, Sakai T, Mosher DF, Brinckmann J, Reinhardt DP. Roles of fibronectin isoforms in neonatal vascular development and matrix integrity. PLoS Biol. 2018 07; 16(7):e2004812. PMID: 30036393; PMCID: PMC6072322.
    Citations: 7     Fields:    Translation:AnimalsCells
  10. Pezzoli D, Di Paolo J, Kumra H, Fois G, Candiani G, Reinhardt DP, Mantovani D. Fibronectin promotes elastin deposition, elasticity and mechanical strength in cellularised collagen-based scaffolds. Biomaterials. 2018 10; 180:130-142. PMID: 30036726.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  11. Camasão DB, Pezzoli D, Loy C, Kumra H, Levesque L, Reinhardt DP, Candiani G, Mantovani D. Increasing Cell Seeding Density Improves Elastin Expression and Mechanical Properties in Collagen Gel-Based Scaffolds Cellularized with Smooth Muscle Cells. Biotechnol J. 2019 Mar; 14(3):e1700768. PMID: 29802760.
    Citations: 2     Fields:    Translation:HumansCells
  12. Kumra H, Reinhardt DP. Fibrillins. Methods Cell Biol. 2018; 143:223-246. PMID: 29310780.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Lee CS, Fu H, Baratang N, Rousseau J, Kumra H, Sutton VR, Niceta M, Ciolfi A, Yamamoto G, Bertola D, Marcelis CL, Lugtenberg D, Bartuli A, Kim C, Hoover-Fong J, Sobreira N, Pauli R, Bacino C, Krakow D, Parboosingh J, Yap P, Kariminejad A, McDonald MT, Aracena MI, Lausch E, Unger S, Superti-Furga A, Lu JT, Cohn DH, Tartaglia M, Lee BH, Reinhardt DP, Campeau PM. Mutations in Fibronectin Cause a Subtype of Spondylometaphyseal Dysplasia with "Corner Fractures". Am J Hum Genet. 2017 Nov 02; 101(5):815-823. PMID: 29100092; PMCID: PMC5673654.
    Citations: 11     Fields:    Translation:Humans
  14. Loy C, Meghezi S, Lévesque L, Pezzoli D, Kumra H, Reinhardt D, Kizhakkedathu JN, Mantovani D. A planar model of the vessel wall from cellularized-collagen scaffolds: focus on cell-matrix interactions in mono-, bi- and tri-culture models. Biomater Sci. 2016 Dec 20; 5(1):153-162. PMID: 27918018.
    Citations: 2     Fields:    Translation:HumansCells
  15. Kumra H, Reinhardt DP. Fibronectin-targeted drug delivery in cancer. Adv Drug Deliv Rev. 2016 Feb 01; 97:101-10. PMID: 26639577.
    Citations: 44     Fields:    Translation:HumansAnimals
  16. Kaur G, Kumar N, Nandakumar R, Rapthap CC, Sharma G, Neolia S, Kumra H, Mahalwar P, Garg A, Kumar S, Kaur J, Hakim M, Kumar L, Mehra NK. Utility of saliva and hair follicles in donor selection for hematopoietic stem cell transplantation and chimerism monitoring. Chimerism. 2012 Jan-Mar; 3(1):9-17. PMID: 22690267.
    Citations: 1     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.