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Thomas Roston, Ph.D., M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cheung CC, Roston T, Davies B, Grewal J, Laksman ZW, Krahn AD. Process of Care and a Practical Toolkit for Evaluating and Managing Arrhythmic Risk in the Cardiogenetic Pregnant Patient. Can J Cardiol. 2021 Aug 17. PMID: 34416260.
    Citations:    Fields:    
  2. Kallas D, Roston TM, Franciosi S, Brett L, Lieve KVV, Kwok SY, Kannankeril PJ, Krahn AD, LaPage MJ, Etheridge S, Hill A, Johnsrude C, Perry J, Knight L, Fischbach P, Balaji S, Tisma-Dupanovic S, Law I, Atallah J, Backhoff D, Kamp A, Kubus P, Kean A, Aziz PF, Kovach J, Lau Y, Kron J, Clur SA, Sarquella-Brugada G, Wilde AAM, Sanatani S. Evaluation of age at symptom onset, proband status, and sex as predictors of disease severity in pediatric catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 2021 Jul 29. PMID: 34333088.
    Citations:    Fields:    
  3. Roston TM, Grewal J, Krahn AD. Pregnancy in catecholaminergic polymorphic ventricular tachycardia: therapeutic optimization and multidisciplinary care are key to success. Herzschrittmacherther Elektrophysiol. 2021 Jun; 32(2):199-206. PMID: 33881608.
    Citations:    Fields:    Translation:Humans
  4. Roston TM, Kallas D, Davies B, Franciosi S, De Souza AM, Laksman ZW, Sanatani S, Krahn AD. Burst Exercise Testing Can Unmask Arrhythmias in Patients With Incompletely Penetrant Catecholaminergic Polymorphic Ventricular Tachycardia. JACC Clin Electrophysiol. 2021 04; 7(4):437-441. PMID: 33888264.
    Citations:    Fields:    Translation:Humans
  5. Sun B, Yao J, Ni M, Wei J, Zhong X, Guo W, Zhang L, Wang R, Belke D, Chen YX, Lieve KVV, Broendberg AK, Roston TM, Blankoff I, Kammeraad JA, von Alvensleben JC, Lazarte J, Vallmitjana A, Bohne LJ, Rose RA, Benitez R, Hove-Madsen L, Napolitano C, Hegele RA, Fill M, Sanatani S, Wilde AAM, Roberts JD, Priori SG, Jensen HK, Chen SRW. Cardiac ryanodine receptor calcium release deficiency syndrome. Sci Transl Med. 2021 02 03; 13(579). PMID: 33536282.
    Citations: 2     Fields:    Translation:Animals
  6. Clunies-Ross N, Roston TM, Taylor J, Whyte S, Albert A, Görges M, Chau A. The Effect of Carbetocin Dose on Transmural Dispersion of Myocardial Repolarization in Healthy Parturients Scheduled for Elective Cesarean Delivery Under Spinal Anesthesia: A Prospective, Randomized Clinical Trial. Anesth Analg. 2021 02 01; 132(2):485-492. PMID: 32149759.
    Citations:    Fields:    Translation:Humans
  7. Roston TM, De Souza AM, Romans HV, Franciosi S, Armstrong KR, Sanatani S. Potential overdiagnosis of long QT syndrome using exercise stress and QT stand testing in children and adolescents with a low probability of disease. J Cardiovasc Electrophysiol. 2021 02; 32(2):500-506. PMID: 33382510.
    Citations:    Fields:    Translation:Humans
  8. Roston TM, Hylind RJ, Abrams DJ. Causal Genetic Variants in Stillbirth. N Engl J Med. 2020 12 31; 383(27):2687. PMID: 33382937.
    Citations:    Fields:    Translation:Humans
  9. Huang K, Trinder M, Roston TM, Laksman ZW, Brunham LR. The Interplay Between Titin, Polygenic Risk, and Modifiable Cardiovascular Risk Factors in Atrial Fibrillation. Can J Cardiol. 2021 Jun; 37(6):848-856. PMID: 33373724.
    Citations: 1     Fields:    
  10. Ng K, Titus EW, Lieve KV, Roston TM, Mazzanti A, Deiter FH, Denjoy I, Ingles J, Till J, Robyns T, Connors SP, Steinberg C, Abrams DJ, Pang B, Scheinman MM, Bos JM, Duffett SA, van der Werf C, Maltret A, Green MS, Rutberg J, Balaji S, Cadrin-Tourigny J, Orland KM, Knight LM, Brateng C, Wu J, Tang AS, Skanes AC, Manlucu J, Healey JS, January CT, Krahn AD, Collins KK, Maginot KR, Fischbach P, Etheridge SP, Eckhardt LL, Hamilton RM, Ackerman MJ, Noguer FRI, Semsarian C, Jura N, Leenhardt A, Gollob MH, Priori SG, Sanatani S, Wilde AAM, Deo RC, Roberts JD. An International Multicenter Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2-Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation. 2020 09 08; 142(10):932-947. PMID: 32693635.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  11. Lieve KVV, Dusi V, van der Werf C, Bos JM, Lane CM, Stokke MK, Roston TM, Djupsjöbacka A, Wada Y, Denjoy I, Bundgaard H, Noguer FRI, Semsarian C, Robyns T, Hofman N, Tanck MW, van den Berg MP, Kammeraad JAE, Krahn AD, Clur SB, Sacher F, Till J, Skinner JR, Tfelt-Hansen J, Probst V, Leenhardt A, Horie M, Swan H, Roberts JD, Sanatani S, Haugaa KH, Schwartz PJ, Ackerman MJ, Wilde AAM. Heart Rate Recovery After Exercise Is Associated With Arrhythmic Events in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Arrhythm Electrophysiol. 2020 03; 13(3):e007471. PMID: 32063070.
    Citations: 1     Fields:    Translation:Humans
  12. Cunningham T, Roston TM, Franciosi S, Liu MC, Atallah J, Escudero CA, Udupa S, Roberts JD, Dhillon S, Dallaire F, Fournier A, Fatah M, Hamilton R, Sanatani S. Initially unexplained cardiac arrest in children and adolescents: A national experience from the Canadian Pediatric Heart Rhythm Network. Heart Rhythm. 2020 06; 17(6):975-981. PMID: 32036023.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  13. Li CO, Roston TM, MacEwing C, Sanatani S. To play or not to play? sports participation and shared decision-making in athletes with inherited heart rhythm disorders. Br J Sports Med. 2020 Oct; 54(19):1126-1128. PMID: 31980420.
    Citations:    Fields:    Translation:Humans
  14. Roberts JD, Asaki SY, Mazzanti A, Bos JM, Tuleta I, Muir AR, Crotti L, Krahn AD, Kutyifa V, Shoemaker MB, Johnsrude CL, Aiba T, Marcondes L, Baban A, Udupa S, Dechert B, Fischbach P, Knight LM, Vittinghoff E, Kukavica D, Stallmeyer B, Giudicessi JR, Spazzolini C, Shimamoto K, Tadros R, Cadrin-Tourigny J, Duff HJ, Simpson CS, Roston TM, Wijeyeratne YD, El Hajjaji I, Yousif MD, Gula LJ, Leong-Sit P, Chavali N, Landstrom AP, Marcus GM, Dittmann S, Wilde AAM, Behr ER, Tfelt-Hansen J, Scheinman MM, Perez MV, Kaski JP, Gow RM, Drago F, Aziz PF, Abrams DJ, Gollob MH, Skinner JR, Shimizu W, Kaufman ES, Roden DM, Zareba W, Schwartz PJ, Schulze-Bahr E, Etheridge SP, Priori SG, Ackerman MJ. An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition. Circulation. 2020 02 11; 141(6):429-439. PMID: 31941373.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  15. Cheung CC, Roston TM, Andrade JG, Bennett MT, Davis MK. Arrhythmias in Cardiac Amyloidosis: Challenges in Risk Stratification and Treatment. Can J Cardiol. 2020 03; 36(3):416-423. PMID: 32145868.
    Citations: 3     Fields:    Translation:Humans
  16. Roston TM, Krahn AD, Ong K, Sanatani S. The merits of the ICD for inherited heart rhythm disorders: A critical re-appraisal. Trends Cardiovasc Med. 2020 10; 30(7):415-421. PMID: 31685385.
    Citations:    Fields:    Translation:Humans
  17. van der Werf C, Lieve KV, Bos JM, Lane CM, Denjoy I, Roses-Noguer F, Aiba T, Wada Y, Ingles J, Leren IS, Rudic B, Schwartz PJ, Maltret A, Sacher F, Skinner JR, Krahn AD, Roston TM, Tfelt-Hansen J, Swan H, Robyns T, Ohno S, Roberts JD, van den Berg MP, Kammeraad JA, Probst V, Kannankeril PJ, Blom NA, Behr ER, Borggrefe M, Haugaa KH, Semsarian C, Horie M, Shimizu W, Till JA, Leenhardt A, Ackerman MJ, Wilde AA. Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest. Eur Heart J. 2019 09 14; 40(35):2953-2961. PMID: 31145795.
    Citations: 10     Fields:    
  18. Roston TM, van der Werf C, Cheung CC, Grewal J, Davies B, Wilde AAM, Krahn AD. Caring for the pregnant woman with an inherited arrhythmia syndrome. Heart Rhythm. 2020 02; 17(2):341-348. PMID: 31400520.
    Citations: 8     Fields:    Translation:Humans
  19. Roston TM, Hart A, Krahn AD, Sanatani S. The challenge of implantable cardioverter-defibrillator programming and shock interpretation in treatment-refractory catecholaminergic polymorphic ventricular tachycardia. J Cardiovasc Med (Hagerstown). 2019 Aug; 20(8):569-571. PMID: 31090560.
    Citations:    Fields:    Translation:Humans
  20. Franciosi S, Roston TM, Perry FKG, Knollmann BC, Kannankeril PJ, Sanatani S. Chronotropic incompetence as a risk predictor in children and young adults with catecholaminergic polymorphic ventricular tachycardia. J Cardiovasc Electrophysiol. 2019 10; 30(10):1923-1929. PMID: 31231889.
    Citations: 2     Fields:    Translation:Humans
  21. Laksman Z, Barichello S, Roston TM, Deyell MW, Krahn AD. Acute Management of Ventricular Arrhythmia in Patients With Suspected Inherited Heart Rhythm Disorders. JACC Clin Electrophysiol. 2019 Mar; 5(3):267-283. PMID: 30898228.
    Citations:    Fields:    Translation:Humans
  22. Roston TM, Chua D, Lum E, Krahn AD. Switching Between ß-Blockers: An Empiric Tool for the Cardiovascular Practitioner. Can J Cardiol. 2019 04; 35(4):539-543. PMID: 30935645.
    Citations: 1     Fields:    Translation:Humans
  23. Cheung CC, Lieve KV, Roston TM, van der Ree MH, Deyell MW, Andrade JG, Laksman ZW, Nannenberg EA, Tadros R, Pang B, Rutberg J, Green MS, Conacher S, Seifer CM, Roberts JD, Steinberg C, Sanatani S, Wilde AA, Krahn AD. Pregnancy in Catecholaminergic Polymorphic Ventricular Tachycardia. JACC Clin Electrophysiol. 2019 03; 5(3):387-394. PMID: 30898243.
    Citations: 4     Fields:    Translation:Humans
  24. Roston TM, Haji-Ghassemi O, LaPage MJ, Batra AS, Bar-Cohen Y, Anderson C, Lau YR, Maginot K, Gebauer RA, Etheridge SP, Potts JE, Van Petegem F, Sanatani S. Catecholaminergic polymorphic ventricular tachycardia patients with multiple genetic variants in the PACES CPVT Registry. PLoS One. 2018; 13(11):e0205925. PMID: 30403697.
    Citations: 4     Fields:    Translation:HumansCells
  25. Kallas D, Franciosi S, Tester M, Roston TM, Sanatani S. Dynamic Electrocardiographic Abnormalities Captured in Timothy Syndrome. JACC Clin Electrophysiol. 2018 11; 4(11):1486-1487. PMID: 30466860.
    Citations:    Fields:    Translation:Humans
  26. Roston TM, Sanatani S. Beyond the exercise stress test: Does the cardiac ryanodine receptor affect intellectual function? Heart Rhythm. 2019 02; 16(2):229-230. PMID: 30217527.
    Citations:    Fields:    Translation:Humans
  27. Roston TM, Jones K, Hawkins NM, Bos JM, Schwartz PJ, Perry F, Ackerman MJ, Laksman ZWM, Kaul P, Lieve KVV, Atallah J, Krahn AD, Sanatani S. Implantable cardioverter-defibrillator use in catecholaminergic polymorphic ventricular tachycardia: A systematic review. Heart Rhythm. 2018 12; 15(12):1791-1799. PMID: 30063211.
    Citations: 13     Fields:    Translation:Humans
  28. Roston TM, Yuchi Z, Kannankeril PJ, Hathaway J, Vinocur JM, Etheridge SP, Potts JE, Maginot KR, Salerno JC, Cohen MI, Hamilton RM, Pflaumer A, Mohammed S, Kimlicka L, Kanter RJ, LaPage MJ, Collins KK, Gebauer RA, Temple JD, Batra AS, Erickson C, Miszczak-Knecht M, Kubuš P, Bar-Cohen Y, Kantoch M, Thomas VC, Hessling G, Anderson C, Young ML, Choi SHJ, Cabrera Ortega M, Lau YR, Johnsrude CL, Fournier A, Van Petegem F, Sanatani S. The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry. Europace. 2018 03 01; 20(3):541-547. PMID: 28158428.
    Citations: 20     Fields:    Translation:HumansCells
  29. Sergeev V, Perry F, Roston TM, Sanatani S, Tibbits GF, Claydon TW. Functional characterization of a novel hERG variant in a family with recurrent sudden infant death syndrome: Retracting a genetic diagnosis. Forensic Sci Int. 2018 Mar; 284:39-45. PMID: 29331839.
    Citations:    Fields:    Translation:Humans
  30. Roston TM, Tran DT, Sanatani S, Sandhu R, Sheldon R, Kaul P. A Population-Based Study of Syncope in the Young. Can J Cardiol. 2018 02; 34(2):195-201. PMID: 29407009.
    Citations: 2     Fields:    Translation:Humans
  31. Roston TM, Dewar L, Franciosi S, Hathaway J, Bartels K, Cunningham T, Gibbs KA, Sheps S, Laksman ZWM, Sanatani S, Krahn AD. The accessibility and utilization of genetic testing for inherited heart rhythm disorders: a Canadian cross-sectional survey study. J Community Genet. 2018 Jul; 9(3):257-262. PMID: 29170972.
    Citations: 3     
  32. Roston T, Krahn AD. My Approach to the patient with a borderline long QT interval. Trends Cardiovasc Med. 2017 10; 27(7):516-517. PMID: 28684210.
    Citations:    Fields:    Translation:Humans
  33. Franciosi S, Perry FKG, Roston TM, Armstrong KR, Claydon VE, Sanatani S. The role of the autonomic nervous system in arrhythmias and sudden cardiac death. Auton Neurosci. 2017 07; 205:1-11. PMID: 28392310.
    Citations: 24     Fields:    Translation:HumansAnimals
  34. Roston TM, Cunningham T, Lehman A, Laksman ZW, Krahn AD, Sanatani S. Beyond the Electrocardiogram: Mutations in Cardiac Ion Channel Genes Underlie Nonarrhythmic Phenotypes. Clin Med Insights Cardiol. 2017; 11:1179546817698134. PMID: 28469493.
    Citations:    
  35. Roston TM, Van Petegem F, Sanatani S. Catecholaminergic polymorphic ventricular tachycardia: a model for genotype-specific therapy. Curr Opin Cardiol. 2017 01; 32(1):78-85. PMID: 27861184.
    Citations: 10     Fields:    Translation:HumansAnimals
  36. Roston TM, Cunningham TC, Sanatani S. Advances in the diagnosis and treatment of catecholaminergic polymorphic ventricular tachycardia. Cardiol Young. 2017 Jan; 27(S1):S49-S56. PMID: 28084961.
    Citations: 1     Fields:    Translation:Humans
  37. Roston TM, Sanatani S. Management of Gene-Positive Catecholaminergic Polymorphic Ventricular Tachycardia: Are the Long Term Outcomes on Therapy Really So Poor? Circ J. 2016 Nov 25; 80(12):2565. PMID: 27840378.
    Citations:    Fields:    Translation:Humans
  38. Roston TM, Sanatani S, Chen SR. Suppression-of-function mutations in the cardiac ryanodine receptor: Emerging evidence for a novel arrhythmia syndrome? Heart Rhythm. 2017 01; 14(1):108-109. PMID: 27818320.
    Citations: 4     Fields:    Translation:Humans
  39. Roston TM, Guo W, Krahn AD, Wang R, Van Petegem F, Sanatani S, Chen SR, Lehman A. A novel RYR2 loss-of-function mutation (I4855M) is associated with left ventricular non-compaction and atypical catecholaminergic polymorphic ventricular tachycardia. J Electrocardiol. 2017 Mar - Apr; 50(2):227-233. PMID: 27646203.
    Citations: 12     Fields:    Translation:Humans
  40. Padfield GJ, AlAhmari L, Lieve KV, AlAhmari T, Roston TM, Wilde AA, Krahn AD, Sanatani S. Flecainide monotherapy is an option for selected patients with catecholaminergic polymorphic ventricular tachycardia intolerant of ß-blockade. Heart Rhythm. 2016 Feb; 13(2):609-13. PMID: 26416620.
    Citations: 10     Fields:    Translation:Humans
  41. Roston TM, AlAhmari L, Krahn AD, Sherwin E, Sanatani S. Choking-induced cardiac arrest unmasks a diagnosis of catecholaminergic polymorphic ventricular tachycardia. HeartRhythm Case Rep. 2015 Nov; 1(6):494-497. PMID: 28491614.
    Citations:    
  42. Roston TM, Vinocur JM, Maginot KR, Mohammed S, Salerno JC, Etheridge SP, Cohen M, Hamilton RM, Pflaumer A, Kanter RJ, Potts JE, LaPage MJ, Collins KK, Gebauer RA, Temple JD, Batra AS, Erickson C, Miszczak-Knecht M, Kubuš P, Bar-Cohen Y, Kantoch M, Thomas VC, Hessling G, Anderson C, Young ML, Cabrera Ortega M, Lau YR, Johnsrude CL, Fournier A, Kannankeril PJ, Sanatani S. Catecholaminergic polymorphic ventricular tachycardia in children: analysis of therapeutic strategies and outcomes from an international multicenter registry. Circ Arrhythm Electrophysiol. 2015 Jun; 8(3):633-42. PMID: 25713214.
    Citations: 40     Fields:    Translation:Humans
  43. Roston TM, De Souza AM, Sandor GG, Sanatani S, Potts JE. Physical activity recommendations for patients with electrophysiologic and structural congenital heart disease: a survey of Canadian health care providers. Pediatr Cardiol. 2013 Aug; 34(6):1374-81. PMID: 23435716.
    Citations: 2     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.