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Sean R. Stowell, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL138714 (STOWELL, SEAN R) Aug 15, 2020 - May 31, 2024
    NIH/NHLBI
    Impact of Anemia and Its Treatment on Gut Injury in Preterm Infants
    Role: Principal Investigator
  2. U01CA242109 (STOWELL, SEAN R) Jul 3, 2019 - Jun 30, 2022
    NIH/NCI
    Integrating microbial glycan arrays with genomic sequences to study host microbe interactions
    Role: Principal Investigator
  3. R01HL138656 (ROBACK, JOHN D) Sep 1, 2017 - Jun 30, 2021
    NIH/NHLBI
    Engineering iPSC-RBCs for Transfusion
    Role: Co-Principal Investigator
  4. R01HL135575 (STOWELL, SEAN R) May 1, 2017 - Apr 30, 2021
    NIH/NHLBI
    Examination of Initiating Factors that Regulate Red Blood Cell Alloimmunization
    Role: Principal Investigator
  5. DP5OD019892 (STOWELL, SEAN R) Sep 12, 2014 - Aug 31, 2019
    NIH
    Examination of Innate Immunity Against Molecular Mimicry
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chonat S, Mener A, Verkerke H, Stowell SR. Role of complement in alloimmunization and hyperhemolysis. Curr Opin Hematol. 2020 Nov; 27(6):406-414. PMID: 32889827.
    Citations:    
  2. Rodriguez Z, Shane AL, Verkerke H, Lough C, Zimmerman MG, Suthar M, Wrammert J, MacDonald H, Wolf M, Clarke S, Roback JD, Arthur CM, Stowell SR, Josephson CD. COVID-19 convalescent plasma clears SARS-CoV-2 refractory to remdesivir in an infant with congenital heart disease. Blood Adv. 2020 09 22; 4(18):4278-4281. PMID: 32915971.
    Citations:    
  3. Moosavi MM, Goodman AL, Duncan A, Stowell SR, Waller EK, Roback JD, Sullivan HC. Development of iron deficiency anemia in patients undergoing extracorporeal photopheresis: Comparison of the UVAR and CELLEX instruments. J Clin Apher. 2020 Sep 07. PMID: 32894888.
    Citations:    
  4. Vallecillo-Zúniga ML, Rathgeber MF, Poulson PD, Hayes S, Luddington JS, Gill HN, Teynor M, Kartchner BC, Valdoz J, Stowell C, Markham AR, Arthur C, Stowell S, Van Ry PM. Treatment with galectin-1 improves myogenic potential and membrane repair in dysferlin-deficient models. PLoS One. 2020; 15(9):e0238441. PMID: 32881965.
    Citations:    
  5. Chonat S, Graciaa S, Shin HS, Newton JG, Quarmyne MO, Boudreaux J, Tang A, Zerra PE, Rollins MR, Josephson CD, Brown C, Joiner CH, Fasano RM, Stowell SR. Eculizumab for complement mediated thrombotic microangiopathy in sickle cell disease. Haematologica. 2020 Jul 30. PMID: 32732358.
    Citations:    
  6. Kudelka MR, Stowell SR, Cummings RD, Neish AS. Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD. Nat Rev Gastroenterol Hepatol. 2020 Oct; 17(10):597-617. PMID: 32710014.
    Citations:    
  7. Jiang Y, Wen T, Yan R, Kim SR, Stowell SR, Wang W, Wang Y, An G, Cummings RD, Ju T. O-glycans on death receptors in cells modulate their sensitivity to TRAIL-induced apoptosis through affecting on their stability and oligomerization. FASEB J. 2020 Jul 21. PMID: 32692906.
    Citations:    
  8. Moosavi MM, Duncan A, Stowell SR, Roback JD, Sullivan HC. Passenger Lymphocyte Syndrome; a Review of the Diagnosis, Treatment, and Proposed Detection Protocol. Transfus Med Rev. 2020 Jul; 34(3):178-187. PMID: 32826130.
    Citations:    
  9. Zerra PE, Arthur CM, Chonat S, Maier CL, Mener A, Shin S, Allen JWL, Baldwin WH, Cox C, Verkerke H, Jajosky RP, Tormey CA, Meeks SL, Stowell SR. Fc Gamma Receptors and Complement Component 3 Facilitate Anti-fVIII Antibody Formation. Front Immunol. 2020; 11:905. PMID: 32582142.
    Citations:    
  10. Suthar MS, Zimmerman MG, Kauffman RC, Mantus G, Linderman SL, Hudson WH, Vanderheiden A, Nyhoff L, Davis CW, Adekunle O, Affer M, Sherman M, Reynolds S, Verkerke HP, Alter DN, Guarner J, Bryksin J, Horwath MC, Arthur CM, Saakadze N, Smith GH, Edupuganti S, Scherer EM, Hellmeister K, Cheng A, Morales JA, Neish AS, Stowell SR, Frank F, Ortlund E, Anderson EJ, Menachery VD, Rouphael N, Mehta AK, Stephens DS, Ahmed R, Roback JD, Wrammert J. Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients. Cell Rep Med. 2020 Jun 23; 1(3):100040. PMID: 32835303.
    Citations:    
  11. Escamilla-Rivera V, Liu J, Gibb DR, Santhanakrishnan M, Liu D, Forsmo JE, Eisenbarth SC, Foxman EF, Stowell SR, Luckey CJ, Zimring JC, Hudson KE, Hendrickson JE. Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice. Blood. 2020 May 28; 135(22):1983-1993. PMID: 32266378.
    Citations:    
  12. Lee-Sundlov MM, Stowell SR, Hoffmeister KM. Multifaceted role of glycosylation in transfusion medicine, platelets, and red blood cells. J Thromb Haemost. 2020 Jul; 18(7):1535-1547. PMID: 32350996.
    Citations:    
  13. Suthar MS, Zimmerman M, Kauffman R, Mantus G, Linderman S, Vanderheiden A, Nyhoff L, Davis C, Adekunle S, Affer M, Sherman M, Reynolds S, Verkerke H, Alter DN, Guarner J, Bryksin J, Horwath M, Arthur C, Saakadze N, Smith GH, Edupuganti S, Scherer EM, Hellmeister K, Cheng A, Morales JA, Neish AS, Stowell SR, Frank F, Ortlund E, Anderson E, Menachery V, Rouphael N, Metha A, Stephens DS, Ahmed R, Roback J, Wrammert J. Rapid generation of neutralizing antibody responses in COVID-19 patients. medRxiv. 2020 May 08. PMID: 32511565.
    Citations:    
  14. Robinson BS, Saeedi B, Arthur CM, Owens J, Naudin C, Ahmed N, Luo L, Jones R, Neish A, Stowell SR. Galectin-9 Is a Novel Regulator of Epithelial Restitution. Am J Pathol. 2020 08; 190(8):1657-1666. PMID: 32380082.
    Citations:    
  15. Stowell S, Guarner J. Role of serology in the COVID-19 pandemic. Clin Infect Dis. 2020 May 01. PMID: 32357206.
    Citations:    
  16. Carden MA, Gaddh M, Hoskote A, Brown M, Merrill V, Stowell SR, Chandrakasan S, Antun A, Kudchadkar R, Kotanchiyev S, Jaye DL, Bodó I. Rituximab leads to early elimination of circulating CD20+ T and B lymphocytes in patients with iTTP despite ongoing TPEx. Blood Adv. 2020 02 11; 4(3):477-481. PMID: 32027742.
    Citations:    
  17. Thein SL, Pirenne F, Fasano RM, Habibi A, Bartolucci P, Chonat S, Hendrickson JE, Stowell SR. Hemolytic transfusion reactions in sickle cell disease: underappreciated and potentially fatal. Haematologica. 2020 Mar; 105(3):539-544. PMID: 32029505.
    Citations:    
  18. Chou ST, Alsawas M, Fasano RM, Field JJ, Hendrickson JE, Howard J, Kameka M, Kwiatkowski JL, Pirenne F, Shi PA, Stowell SR, Thein SL, Westhoff CM, Wong TE, Akl EA. American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support. Blood Adv. 2020 Jan 28; 4(2):327-355. PMID: 31985807.
    Citations:    
  19. Rodrigues LC, Kabeya LM, Azzolini AECS, Cerri DG, Stowell SR, Cummings RD, Lucisano-Valim YM, Dias-Baruffi M. Corrigendum to "Galectin-1 modulation of neutrophil reactive oxygen species production depends on the cell activation state" [Mol. Immunol. 116 (2019) 80-89]. Mol Immunol. 2020 Mar; 119:59-63. PMID: 31978708.
    Citations:    
  20. Vlaar AP, Stowell SR. Intersection Between Complement and Transfusion Medicine. Transfus Med Rev. 2019 10; 33(4):197-198. PMID: 31679760.
    Citations:    
  21. Cutler CE, Jones MB, Cutler AA, Mener A, Arthur CM, Stowell SR, Cummings RD. Cosmc is required for T cell persistence in the periphery. Glycobiology. 2019 10 21; 29(11):776-788. PMID: 31317176.
    Citations:    
  22. Arthur CM, Chonat S, Fasano R, Yee MEM, Josephson CD, Roback JD, Stowell SR. Examining the Role of Complement in Predicting, Preventing, and Treating Hemolytic Transfusion Reactions. Transfus Med Rev. 2019 10; 33(4):217-224. PMID: 31679762.
    Citations:    
  23. Rodrigues LC, Kabeya LM, Azzolini AECS, Cerri DG, Stowell SR, Cummings RD, Lucisano-Valim YM, Dias-Baruffi M. Galectin-1 modulation of neutrophil reactive oxygen species production depends on the cell activation state. Mol Immunol. 2019 12; 116:80-89. PMID: 31630079.
    Citations:    
  24. Robinson BS, Arthur CM, Evavold B, Roback E, Kamili NA, Stowell CS, Vallecillo-Zúniga ML, Van Ry PM, Dias-Baruffi M, Cummings RD, Stowell SR. The Sweet-Side of Leukocytes: Galectins as Master Regulators of Neutrophil Function. Front Immunol. 2019; 10:1762. PMID: 31440233.
    Citations:    
  25. Patel RM, Shenvi N, Knezevic A, Hinkes M, Bugg GW, Stowell SR, Roback JD, Easley KA, Josephson C. Observational study of cytomegalovirus from breast milk and necrotising enterocolitis. Arch Dis Child Fetal Neonatal Ed. 2019 Jul 20. PMID: 31326920.
    Citations:    
  26. Stowell SR, Stowell CP. Biologic roles of the ABH and Lewis histo-blood group antigens part II: thrombosis, cardiovascular disease and metabolism. Vox Sang. 2019 Aug; 114(6):535-552. PMID: 31090093.
    Citations:    
  27. Stowell CP, Stowell SR. Biologic roles of the ABH and Lewis histo-blood group antigens Part I: infection and immunity. Vox Sang. 2019 Jul; 114(5):426-442. PMID: 31070258.
    Citations:    
  28. Chonat S, Arthur CM, Zerra PE, Maier CL, Jajosky RP, Yee MEM, Miller MJ, Josephson CD, Roback JD, Fasano R, Stowell SR. Challenges in preventing and treating hemolytic complications associated with red blood cell transfusion. Transfus Clin Biol. 2019 May; 26(2):130-134. PMID: 30979566.
    Citations:    
  29. Arthur CM, Nalbant D, Feldman HA, Saeedi BJ, Matthews J, Robinson BS, Kamili NA, Bennett A, Cress GA, Sola-Visner M, Jones RM, Zimmerman MB, Neish AS, Patel RM, Nopoulos P, Georgieff MK, Roback JD, Widness JA, Josephson CD, Stowell SR. Anemia induces gut inflammation and injury in an animal model of preterm infants. Transfusion. 2019 04; 59(4):1233-1245. PMID: 30897226.
    Citations:    
  30. Dean CL, Maier CL, Chonat S, Chang A, Carden MA, El Rassi F, McLemore ML, Stowell SR, Fasano RM. Challenges in the treatment and prevention of delayed hemolytic transfusion reactions with hyperhemolysis in sickle cell disease patients. Transfusion. 2019 05; 59(5):1698-1705. PMID: 30848512.
    Citations:    
  31. Fasano RM, Miller MJ, Chonat S, Stowell SR. Clinical presentation of delayed hemolytic transfusion reactions and hyperhemolysis in sickle cell disease. Transfus Clin Biol. 2019 May; 26(2):94-98. PMID: 30837199.
    Citations:    
  32. Maier CL, Asbury WH, Duncan A, Robbins A, Ingle A, Webb A, Stowell SR, Roback JD. Using an old test for new tricks: Measuring direct oral anti-Xa drug levels by conventional heparin-calibrated anti-Xa assay. Am J Hematol. 2019 05; 94(5):E132-E134. PMID: 30734369.
    Citations:    
  33. Sullivan HC, Stowell SR, Meyer EK, Duncan AD, Guarner J. Development, Implementation, and Evaluation of a Fourth-Year Medical School Elective Course in Blood Banking and Transfusion Medicine. Am J Clin Pathol. 2019 01 01; 151(1):116-121. PMID: 30239572.
    Citations:    
  34. Patel RM, Josephson CD, Shenvi N, Maheshwari A, Easley KA, Stowell S, Sola-Visner M, Ferrer-Marin F. Platelet transfusions and mortality in necrotizing enterocolitis. Transfusion. 2019 03; 59(3):981-988. PMID: 30597571.
    Citations:    Fields:    
  35. Mener A, Patel SR, Arthur CM, Stowell SR. Antibody-mediated immunosuppression can result from RBC antigen loss independent of Fc? receptors in mice. Transfusion. 2019 01; 59(1):371-384. PMID: 30474857.
    Citations:    
  36. Patel SR, Gibb DR, Girard-Pierce K, Zhou X, Rodrigues LC, Arthur CM, Bennett AL, Jajosky RP, Fuller M, Maier CL, Zerra PE, Chonat S, Smith NH, Tormey CA, Hendrickson JE, Stowell SR. Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion. Front Immunol. 2018; 9:2516. PMID: 30505302.
    Citations:    
  37. Mener A, Patel SR, Arthur CM, Chonat S, Wieland A, Santhanakrishnan M, Liu J, Maier CL, Jajosky RP, Girard-Pierce K, Bennett A, Zerra PE, Smith NH, Hendrickson JE, Stowell SR. Complement serves as a switch between CD4+ T cell-independent and -dependent RBC antibody responses. JCI Insight. 2018 11 15; 3(22). PMID: 30429364.
    Citations:    
  38. Maier CL, Mener A, Patel SR, Jajosky RP, Bennett AL, Arthur CM, Hendrickson JE, Stowell SR. Antibody-mediated immune suppression by antigen modulation is antigen-specific. Blood Adv. 2018 11 13; 2(21):2986-3000. PMID: 30413434.
    Citations:    
  39. Dean CL, Maier CL, Roback JD, Stowell SR. Multiple hemolytic transfusion reactions misinterpreted as severe vaso-occlusive crisis in a patient with sickle cell disease. Transfusion. 2019 02; 59(2):448-453. PMID: 30412270.
    Citations:    
  40. Madrid DJ, Santhanakrishnan M, Liu J, Gibb DR, Liu D, Natarajan P, Beitler D, Shi Z, Mo C, Tormey CA, Patel SR, Stowell SR, Hendrickson JE. Transfused platelets enhance alloimmune responses to transfused KEL-expressing red blood cells in a murine model. Blood Transfus. 2019 09; 17(5):368-377. PMID: 30418129.
    Citations:    
  41. Dean CL, Sullivan HC, Stowell SR, Fasano RM, West LJ, Robitaille N, Josephson CD. Current state of transfusion practices for ABO-incompatible pediatric heart transplant patients in the United States and Canada. Transfusion. 2018 09; 58(9):2243-2249. PMID: 30145826.
    Citations:    
  42. Marin T, Patel RM, Roback JD, Stowell SR, Guo Y, Easley K, Warnock M, Skvarich J, Josephson CD. Does red blood cell irradiation and/or anemia trigger intestinal injury in premature infants with birth weight?=?1250 g? An observational birth cohort study. BMC Pediatr. 2018 08 11; 18(1):270. PMID: 30098602.
    Citations:    
  43. Ferreira RG, Rodrigues LC, Nascimento DC, Kanashiro A, Melo PH, Borges VF, Gozzi A, da Silva Prado D, Borges MC, Ramalho FS, Stowell SR, Cummings RD, Dias-Baruffi M, Cunha FQ, Alves-Filho JC. Galectin-3 aggravates experimental polymicrobial sepsis by impairing neutrophil recruitment to the infectious focus. J Infect. 2018 11; 77(5):391-397. PMID: 30226191.
    Citations:    Fields:    
  44. Mener A, Arthur CM, Patel SR, Liu J, Hendrickson JE, Stowell SR. Complement Component 3 Negatively Regulates Antibody Response by Modulation of Red Blood Cell Antigen. Front Immunol. 2018; 9:676. PMID: 29942300.
    Citations:    
  45. Chonat S, Quarmyne MO, Bennett CM, Dean CL, Joiner CH, Fasano RM, Stowell SR. Contribution of alternative complement pathway to delayed hemolytic transfusion reaction in sickle cell disease. Haematologica. 2018 10; 103(10):e483-e485. PMID: 29794144.
    Citations:    
  46. Yee MEM, Josephson CD, Winkler AM, Webb J, Luban NLC, Leong T, Stowell SR, Roback JD, Fasano RM. Hemoglobin A clearance in children with sickle cell anemia on chronic transfusion therapy. Transfusion. 2018 06; 58(6):1363-1371. PMID: 29664198.
    Citations:    
  47. Maier CL, Gross PJ, Dean CL, Chonat S, Ip A, McLemore M, El Rassi F, Stowell SR, Josephson CD, Fasano RM. Transfusion-transmitted malaria masquerading as sickle cell crisis with multisystem organ failure. Transfusion. 2018 06; 58(6):1550-1554. PMID: 29524230.
    Citations:    
  48. Sagiv E, Fasano RM, Luban NLC, Josephson CD, Stowell SR, Roback JD, Francis RO, Yee MEM. Glucose-6-phosphate-dehydrogenase deficient red blood cell units are associated with decreased posttransfusion red blood cell survival in children with sickle cell disease. Am J Hematol. 2018 05; 93(5):630-634. PMID: 29377292.
    Citations:    
  49. Sullivan HC, Arthur CM, Thompson L, Patel SR, Stowell SR, Hendrickson JE, Lazarus AH. Anti-RhD reduces levels of detectable RhD antigen following anti-RhD infusion. Transfusion. 2018 02; 58(2):542-544. PMID: 29411397.
    Citations:    
  50. Patel SR, Bennett A, Girard-Pierce K, Maier CL, Chonat S, Arthur CM, Zerra PE, Mener A, Stowell SR. Recipient priming to one RBC alloantigen directly enhances subsequent alloimmunization in mice. Blood Adv. 2018 01 23; 2(2):105-115. PMID: 29365318.
    Citations:    
  51. Nickel RS, Qayed M, Worthington-White D, Stowell SR, Chiang KY. Infusion hemolysis after pediatric major ABO-mismatched bone marrow transplant: Comparison of two red blood cell depletion techniques. Pediatr Blood Cancer. 2018 03; 65(3). PMID: 29115715.
    Citations:    
  52. Zerra PE, Cox C, Baldwin WH, Patel SR, Arthur CM, Lollar P, Meeks SL, Stowell SR. Marginal zone B cells are critical to factor VIII inhibitor formation in mice with hemophilia A. Blood. 2017 12 07; 130(23):2559-2568. PMID: 28978569.
    Citations:    
  53. Yee MEM, Josephson CD, Winkler AM, Webb J, Luban NLC, Leong T, Stowell SR, Fasano RM. Red blood cell minor antigen mismatches during chronic transfusion therapy for sickle cell anemia. Transfusion. 2017 11; 57(11):2738-2746. PMID: 28840600.
    Citations:    
  54. Gibb DR, Liu J, Santhanakrishnan M, Natarajan P, Madrid DJ, Patel S, Eisenbarth SC, Tormey CA, Stowell SR, Iwasaki A, Hendrickson JE. B cells require Type 1 interferon to produce alloantibodies to transfused KEL-expressing red blood cells in mice. Transfusion. 2017 11; 57(11):2595-2608. PMID: 28836263.
    Citations:    
  55. Natarajan P, Liu D, Patel SR, Santhanakrishnan M, Beitler D, Liu J, Gibb DR, Liepkalns JS, Madrid DJ, Eisenbarth SC, Stowell SR, Hendrickson JE. CD4 Depletion or CD40L Blockade Results in Antigen-Specific Tolerance in a Red Blood Cell Alloimmunization Model. Front Immunol. 2017; 8:907. PMID: 28824633.
    Citations:    
  56. Brazil JC, Sumagin R, Stowell SR, Lee G, Louis NA, Cummings RD, Parkos CA. Expression of Lewis-a glycans on polymorphonuclear leukocytes augments function by increasing transmigration. J Leukoc Biol. 2017 09; 102(3):753-762. PMID: 28600306.
    Citations:    Fields:    Translation:HumansCells
  57. Sullivan HC, Gerner-Smidt C, Nooka AK, Arthur CM, Thompson L, Mener A, Patel SR, Yee M, Fasano RM, Josephson CD, Kaufman RM, Roback JD, Lonial S, Stowell SR. Daratumumab (anti-CD38) induces loss of CD38 on red blood cells. Blood. 2017 06 01; 129(22):3033-3037. PMID: 28373263.
    Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
  58. Fasano RM, Sullivan HC, Bray RA, Gebel HM, Meyer EK, Winkler AM, Josephson CD, Stowell SR, Sandy Duncan A, Roback JD. Genotyping Applications for Transplantation and Transfusion Management: The Emory Experience. Arch Pathol Lab Med. 2017 Mar; 141(3):329-340. PMID: 28234571.
    Citations:    
  59. Stowell SR. Toward functional assays for assessing the significance of anti-ABO(H) alloantibodies. Transfusion. 2017 03; 57(3):491-494. PMID: 28297078.
    Citations:    
  60. Arthur CM, Patel SR, Smith NH, Bennett A, Kamili NA, Mener A, Gerner-Smidt C, Sullivan HC, Hale JS, Wieland A, Youngblood B, Zimring JC, Hendrickson JE, Stowell SR. Antigen Density Dictates Immune Responsiveness following Red Blood Cell Transfusion. J Immunol. 2017 04 01; 198(7):2671-2680. PMID: 28250159.
    Citations:    
  61. Holt BA, Bellavia MC, Potter D, White D, Stowell SR, Sulchek T. Fc microparticles can modulate the physical extent and magnitude of complement activity. Biomater Sci. 2017 Feb 28; 5(3):463-474. PMID: 28067347.
    Citations:    
  62. Kudelka MR, Hinrichs BH, Darby T, Moreno CS, Nishio H, Cutler CE, Wang J, Wu H, Zeng J, Wang Y, Ju T, Stowell SR, Nusrat A, Jones RM, Neish AS, Cummings RD. Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk. Proc Natl Acad Sci U S A. 2016 12 20; 113(51):14787-14792. PMID: 27930307.
    Citations: 6     Fields:    Translation:AnimalsCells
  63. Kamili NA, Arthur CM, Gerner-Smidt C, Tafesse E, Blenda A, Dias-Baruffi M, Stowell SR. Key regulators of galectin-glycan interactions. Proteomics. 2016 12; 16(24):3111-3125. PMID: 27582340.
    Citations:    
  64. Kamili NA, Stowell SR. Editorial: Feel the burn: blocking galectin-12 helps leukemic cells differentiate while staying lean. J Leukoc Biol. 2016 10; 100(4):640-642. PMID: 27697918.
    Citations:    
  65. Liu J, Santhanakrishnan M, Natarajan P, Gibb DR, Eisenbarth SC, Tormey CA, Siddon AJ, Stowell SR, Branch DR, Hendrickson JE. Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice. Blood. 2016 12 29; 128(26):3159-3168. PMID: 27688803.
    Citations:    
  66. Rodrigues LC, Secatto A, Sorgi CA, Dejani NN, Medeiros AI, Prado MK, Ramos SG, Cummings RD, Stowell SR, Faccioli LH, Dias-Baruffi M. Protective Effect of Galectin-1 during Histoplasma capsulatum Infection Is Associated with Prostaglandin E2 and Nitric Oxide Modulation. Mediators Inflamm. 2016; 2016:5813794. PMID: 27698545.
    Citations: 1     Fields:    Translation:HumansAnimals
  67. Stowell SR. Working together to block alloimmunization. Blood. 2016 08 25; 128(8):1029-30. PMID: 27563146.
    Citations:    
  68. Sparger KA, Assmann SF, Granger S, Winston A, Christensen RD, Widness JA, Josephson C, Stowell SR, Saxonhouse M, Sola-Visner M. Platelet Transfusion Practices Among Very-Low-Birth-Weight Infants. JAMA Pediatr. 2016 07 01; 170(7):687-94. PMID: 27213618.
    Citations: 3     Fields:    Translation:Humans
  69. Calabro S, Gallman A, Gowthaman U, Liu D, Chen P, Liu J, Krishnaswamy JK, Nascimento MS, Xu L, Patel SR, Williams A, Tormey CA, Hod EA, Spitalnik SL, Zimring JC, Hendrickson JE, Stowell SR, Eisenbarth SC. Bridging channel dendritic cells induce immunity to transfused red blood cells. J Exp Med. 2016 05 30; 213(6):887-96. PMID: 27185856.
    Citations:    
  70. Arthur CM, Patel SR, Sullivan HC, Winkler AM, Tormey CA, Hendrickson JE, Stowell SR. CD8+ T cells mediate antibody-independent platelet clearance in mice. Blood. 2016 Apr 07; 127(14):1823-7. PMID: 26787734.
    Citations:    
  71. Arthur CM, Patel SR, Mener A, Kamili NA, Fasano RM, Meyer E, Winkler AM, Sola-Visner M, Josephson CD, Stowell SR. Innate immunity against molecular mimicry: Examining galectin-mediated antimicrobial activity. Bioessays. 2015 Dec; 37(12):1327-37. PMID: 26577077.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  72. Nickel RS, Hendrickson JE, Fasano RM, Meyer EK, Winkler AM, Yee MM, Lane PA, Jones YA, Pashankar FD, New T, Josephson CD, Stowell SR. Impact of red blood cell alloimmunization on sickle cell disease mortality: a case series. Transfusion. 2016 Jan; 56(1):107-14. PMID: 26509333.
    Citations:    
  73. Stowell SR, Arthur CM, Girard-Pierce KR, Sullivan HC, Santhanakrishnan M, Natarajan P, Patel SR, Tormey CA, Zimring JC, Hendrickson JE. Anti-KEL sera prevents alloimmunization to transfused KEL RBCs in a murine model. Haematologica. 2015 Oct; 100(10):e394-7. PMID: 26185172.
    Citations:    
  74. Wieland A, Shashidharamurthy R, Kamphorst AO, Han JH, Aubert RD, Choudhury BP, Stowell SR, Lee J, Punkosdy GA, Shlomchik MJ, Selvaraj P, Ahmed R. Antibody effector functions mediated by Fc?-receptors are compromised during persistent viral infection. Immunity. 2015 Feb 17; 42(2):367-378. PMID: 25680276.
    Citations:    
  75. Leppänen A, Arthur CM, Stowell SR, Cummings RD. Examination of whole cell galectin binding by solid phase and flow cytometric analysis. Methods Mol Biol. 2015; 1207:91-104. PMID: 25253135.
    Citations:    Fields:    Translation:HumansAnimalsCells
  76. Stowell SR, Arthur CM, Cummings RD, Feasley CL. Alkylation of galectin-1 with iodoacetamide and mass spectrometric mapping of the sites of incorporation. Methods Mol Biol. 2015; 1207:51-62. PMID: 25253132.
    Citations: 1     Fields:    Translation:Cells
  77. Stowell SR, Ju T, Cummings RD. Protein glycosylation in cancer. Annu Rev Pathol. 2015; 10:473-510. PMID: 25621663.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  78. Arthur CM, Rodrigues LC, Baruffi MD, Sullivan HC, Heimburg-Molinaro J, Smith DF, Cummings RD, Stowell SR. Examining galectin binding specificity using glycan microarrays. Methods Mol Biol. 2015; 1207:115-31. PMID: 25253137.
    Citations: 1     Fields:    Translation:Cells
  79. Cerri DG, Arthur CM, Rodrigues LC, Fermino ML, Rocha LB, Stowell SR, Baruffi MD. Examination of galectin localization using confocal microscopy. Methods Mol Biol. 2015; 1207:343-54. PMID: 25253152.
    Citations:    
  80. Arthur CM, Cummings RD, Stowell SR. Evaluation of the bactericidal activity of galectins. Methods Mol Biol. 2015; 1207:421-30. PMID: 25253156.
    Citations: 2     Fields:    Translation:Cells
  81. Arthur CM, Rodrigues LC, Baruffi MD, Sullivan HC, Cummings RD, Stowell SR. Detection of phosphatidylserine exposure on leukocytes following treatment with human galectins. Methods Mol Biol. 2015; 1207:185-200. PMID: 25253141.
    Citations: 1     Fields:    Translation:HumansCells
  82. Arthur CM, Baruffi MD, Cummings RD, Stowell SR. Evolving mechanistic insights into galectin functions. Methods Mol Biol. 2015; 1207:1-35. PMID: 25253130.
    Citations: 11     Fields:    Translation:HumansAnimals
  83. Toledo KA, Fermino ML, Andrade Cdel C, Riul TB, Alves RT, Muller VD, Russo RR, Stowell SR, Cummings RD, Aquino VH, Dias-Baruffi M. Galectin-1 exerts inhibitory effects during DENV-1 infection. PLoS One. 2014; 9(11):e112474. PMID: 25392933.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  84. Yu H, Stowell SR, Bernardo L, Hendrickson JE, Zimring JC, Amash A, Uchikawa M, Lazarus AH. Antibody-mediated immune suppression of erythrocyte alloimmunization can occur independently from red cell clearance or epitope masking in a murine model. J Immunol. 2014 Sep 15; 193(6):2902-10. PMID: 25122924.
    Citations:    
  85. Sartim MA, Riul TB, Del Cistia-Andrade C, Stowell SR, Arthur CM, Sorgi CA, Faccioli LH, Cummings RD, Dias-Baruffi M, Sampaio SV. Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation. Glycobiology. 2014 Nov; 24(11):1010-21. PMID: 24973254.
    Citations: 2     Fields:    Translation:AnimalsCells
  86. Stowell SR, Arthur CM, McBride R, Berger O, Razi N, Heimburg-Molinaro J, Rodrigues LC, Gourdine JP, Noll AJ, von Gunten S, Smith DF, Knirel YA, Paulson JC, Cummings RD. Microbial glycan microarrays define key features of host-microbial interactions. Nat Chem Biol. 2014 Jun; 10(6):470-6. PMID: 24814672.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  87. Jiang K, Rankin CR, Nava P, Sumagin R, Kamekura R, Stowell SR, Feng M, Parkos CA, Nusrat A. Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion. J Biol Chem. 2014 Apr 11; 289(15):10510-7. PMID: 24567334.
    Citations:    
  88. Arthur CM, Cummings RD, Stowell SR. Using glycan microarrays to understand immunity. Curr Opin Chem Biol. 2014 Feb; 18:55-61. PMID: 24486647.
    Citations: 22     Fields:    Translation:HumansAnimals
  89. Stowell SR, Liepkalns JS, Hendrickson JE, Girard-Pierce KR, Smith NH, Arthur CM, Zimring JC. Antigen modulation confers protection to red blood cells from antibody through Fc? receptor ligation. J Immunol. 2013 Nov 15; 191(10):5013-25. PMID: 24108700.
    Citations:    
  90. Girard-Pierce KR, Stowell SR, Smith NH, Arthur CM, Sullivan HC, Hendrickson JE, Zimring JC. A novel role for C3 in antibody-induced red blood cell clearance and antigen modulation. Blood. 2013 Sep 05; 122(10):1793-801. PMID: 23878139.
    Citations:    
  91. Stowell SR, Henry KL, Smith NH, Hudson KE, Halverson GR, Park JC, Bennett AM, Girard-Pierce KR, Arthur CM, Bunting ST, Zimring JC, Hendrickson JE. Alloantibodies to a paternally derived RBC KEL antigen lead to hemolytic disease of the fetus/newborn in a murine model. Blood. 2013 Aug 22; 122(8):1494-504. PMID: 23801629.
    Citations:    
  92. Zimring JC, Smith N, Stowell SR, Johnsen JM, Bell LN, Francis RO, Hod EA, Hendrickson JE, Roback JD, Spitalnik SL. Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model. Transfusion. 2014 Jan; 54(1):137-48. PMID: 23721209.
    Citations:    
  93. Stowell SR, Girard-Pierce KR, Smith NH, Henry KL, Arthur CM, Zimring JC, Hendrickson JE. Transfusion of murine red blood cells expressing the human KEL glycoprotein induces clinically significant alloantibodies. Transfusion. 2014 Jan; 54(1):179-89. PMID: 23621760.
    Citations:    
  94. Stowell SR, Smith NH, Zimring JC, Fu X, Palmer AF, Fontes J, Banerjee U, Yazer MH. Addition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization. Transfusion. 2013 Oct; 53(10):2248-57. PMID: 23384196.
    Citations:    
  95. Molinaro RJ, Winkler AM, Kraft CS, Fantz CR, Stowell SR, Ritchie JC, Koch DD, Heron S, Liebzeit J, Santen SA, Guarner J. Teaching laboratory medicine to medical students: implementation and evaluation. Arch Pathol Lab Med. 2012 Nov; 136(11):1423-9. PMID: 23106588.
    Citations:    
  96. Stowell SR, Winkler AM, Maier CL, Arthur CM, Smith NH, Girard-Pierce KR, Cummings RD, Zimring JC, Hendrickson JE. Initiation and regulation of complement during hemolytic transfusion reactions. Clin Dev Immunol. 2012; 2012:307093. PMID: 23118779.
    Citations: 10     Fields:    Translation:HumansAnimals
  97. Liepkalns JS, Cadwell CM, Stowell SR, Hod EA, Spitalnik SL, Zimring JC. Resistance of a subset of red blood cells to clearance by antibodies in a mouse model of incompatible transfusion. Transfusion. 2013 Jun; 53(6):1319-27. PMID: 23033973.
    Citations:    
  98. Zimring JC, Stowell SR, Johnsen JM, Hendrickson JE. Effects of genetic, epigenetic, and environmental factors on alloimmunization to transfused antigens: Current paradigms and future considerations. Transfus Clin Biol. 2012 Jun; 19(3):125-31. PMID: 22682308.
    Citations:    
  99. Liepkalns JS, Hod EA, Stowell SR, Cadwell CM, Spitalnik SL, Zimring JC. Biphasic clearance of incompatible red blood cells through a novel mechanism requiring neither complement nor Fc? receptors in a murine model. Transfusion. 2012 Dec; 52(12):2631-45. PMID: 22502635.
    Citations:    
  100. Cerliani JP, Stowell SR, Mascanfroni ID, Arthur CM, Cummings RD, Rabinovich GA. Expanding the universe of cytokines and pattern recognition receptors: galectins and glycans in innate immunity. J Clin Immunol. 2011 Feb; 31(1):10-21. PMID: 21184154.
    Citations: 25     Fields:    Translation:HumansAnimals
  101. Poland PA, Rondanino C, Kinlough CL, Heimburg-Molinaro J, Arthur CM, Stowell SR, Smith DF, Hughey RP. Identification and characterization of endogenous galectins expressed in Madin Darby canine kidney cells. J Biol Chem. 2011 Feb 25; 286(8):6780-90. PMID: 21127048.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  102. Shaz BH, Stowell SR, Hillyer CD. Transfusion-related acute lung injury: from bedside to bench and back. Blood. 2011 Feb 03; 117(5):1463-71. PMID: 20944069.
    Citations:    
  103. Lee WY, Weber DA, Laur O, Stowell SR, McCall I, Andargachew R, Cummings RD, Parkos CA. The role of cis dimerization of signal regulatory protein alpha (SIRPalpha) in binding to CD47. J Biol Chem. 2010 Dec 03; 285(49):37953-63. PMID: 20826801.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  104. Stowell SR, Arthur CM, Dias-Baruffi M, Rodrigues LC, Gourdine JP, Heimburg-Molinaro J, Ju T, Molinaro RJ, Rivera-Marrero C, Xia B, Smith DF, Cummings RD. Innate immune lectins kill bacteria expressing blood group antigen. Nat Med. 2010 Mar; 16(3):295-301. PMID: 20154696.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  105. Dias-Baruffi M, Stowell SR, Song SC, Arthur CM, Cho M, Rodrigues LC, Montes MA, Rossi MA, James JA, McEver RP, Cummings RD. Differential expression of immunomodulatory galectin-1 in peripheral leukocytes and adult tissues and its cytosolic organization in striated muscle. Glycobiology. 2010 May; 20(5):507-20. PMID: 20053628.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  106. Babu P, North SJ, Jang-Lee J, Chalabi S, Mackerness K, Stowell SR, Cummings RD, Rankin S, Dell A, Haslam SM. Structural characterisation of neutrophil glycans by ultra sensitive mass spectrometric glycomics methodology. Glycoconj J. 2009 Nov; 26(8):975-86. PMID: 18587645.
    Citations: 29     Fields:    Translation:HumansCells
  107. Song X, Xia B, Stowell SR, Lasanajak Y, Smith DF, Cummings RD. Novel fluorescent glycan microarray strategy reveals ligands for galectins. Chem Biol. 2009 Jan 30; 16(1):36-47. PMID: 19171304.
    Citations: 66     Fields:    Translation:Animals
  108. Stowell SR, Karmakar S, Arthur CM, Ju T, Rodrigues LC, Riul TB, Dias-Baruffi M, Miner J, McEver RP, Cummings RD. Galectin-1 induces reversible phosphatidylserine exposure at the plasma membrane. Mol Biol Cell. 2009 Mar; 20(5):1408-18. PMID: 19116313.
    Citations: 24     Fields:    Translation:HumansCells
  109. Stowell SR, Cho M, Feasley CL, Arthur CM, Song X, Colucci JK, Karmakar S, Mehta P, Dias-Baruffi M, McEver RP, Cummings RD. Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation. J Biol Chem. 2009 Feb 20; 284(8):4989-99. PMID: 19103599.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  110. Cerri DG, Rodrigues LC, Stowell SR, Araujo DD, Coelho MC, Oliveira SR, Bizario JC, Cummings RD, Dias-Baruffi M, Costa MC. Degeneration of dystrophic or injured skeletal muscles induces high expression of Galectin-1. Glycobiology. 2008 Nov; 18(11):842-50. PMID: 18723690.
    Citations:    
  111. Karmakar S, Stowell SR, Cummings RD, McEver RP. Galectin-1 signaling in leukocytes requires expression of complex-type N-glycans. Glycobiology. 2008 Oct; 18(10):770-8. PMID: 18633135.
    Citations: 16     Fields:    Translation:HumansCells
  112. Stowell SR, Arthur CM, Slanina KA, Horton JR, Smith DF, Cummings RD. Dimeric Galectin-8 induces phosphatidylserine exposure in leukocytes through polylactosamine recognition by the C-terminal domain. J Biol Chem. 2008 Jul 18; 283(29):20547-59. PMID: 18456665.
    Citations: 45     Fields:    Translation:HumansCells
  113. Ju T, Lanneau GS, Gautam T, Wang Y, Xia B, Stowell SR, Willard MT, Wang W, Xia JY, Zuna RE, Laszik Z, Benbrook DM, Hanigan MH, Cummings RD. Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc. Cancer Res. 2008 Mar 15; 68(6):1636-46. PMID: 18339842.
    Citations: 72     Fields:    Translation:HumansCells
  114. Stowell SR, Qian Y, Karmakar S, Koyama NS, Dias-Baruffi M, Leffler H, McEver RP, Cummings RD. Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion. J Immunol. 2008 Mar 01; 180(5):3091-102. PMID: 18292532.
    Citations: 67     Fields:    Translation:HumansCells
  115. Stowell SR, Arthur CM, Mehta P, Slanina KA, Blixt O, Leffler H, Smith DF, Cummings RD. Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens. J Biol Chem. 2008 Apr 11; 283(15):10109-23. PMID: 18216021.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  116. Lanneau GS, Skaggs V, Moore K, Stowell S, Zuna R, Gold MA. A LEEP cervical conization is rarely indicated for a two-step discrepancy. J Low Genit Tract Dis. 2007 Jul; 11(3):134-7. PMID: 17596756.
    Citations:    
  117. Rogerio AP, Cardoso CR, Fontanari C, Souza MA, Afonso-Cardoso SR, Silva EV, Koyama NS, Basei FL, Soares EG, Calixto JB, Stowell SR, Dias-Baruffi M, Faccioli LH. Anti-asthmatic potential of a D-galactose-binding lectin from Synadenium carinatum latex. Glycobiology. 2007 Aug; 17(8):795-804. PMID: 17522108.
    Citations:    
  118. Stowell SR, Karmakar S, Stowell CJ, Dias-Baruffi M, McEver RP, Cummings RD. Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells. Blood. 2007 Jan 01; 109(1):219-27. PMID: 16940423.
    Citations: 36     Fields:    Translation:HumansCells
  119. Leppänen A, Stowell S, Blixt O, Cummings RD. Dimeric galectin-1 binds with high affinity to alpha2,3-sialylated and non-sialylated terminal N-acetyllactosamine units on surface-bound extended glycans. J Biol Chem. 2005 Feb 18; 280(7):5549-62. PMID: 15556936.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  120. Stowell SR, Dias-Baruffi M, Penttilä L, Renkonen O, Nyame AK, Cummings RD. Human galectin-1 recognition of poly-N-acetyllactosamine and chimeric polysaccharides. Glycobiology. 2004 Feb; 14(2):157-67. PMID: 14576172.
    Citations: 30     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.