Harvard Catalyst Profiles

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Ryan Austin Denu, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F30CA203271 (DENU, RYAN AUSTIN) Sep 1, 2016 - Aug 31, 2020
    Identifying causes and consequences of centrosome amplification in cancer
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Denu RA, Hematti P. Optimization of oxidative stress for mesenchymal stromal/stem cell engraftment, function and longevity. Free Radic Biol Med. 2021 May 01; 167:193-200. PMID: 33677063.
    Citations:    Fields:    
  2. Matson DR, Denu RA, Zasadil LM, Burkard ME, Weaver BA, Flynn C, Stukenberg PT. High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability. BMC Cancer. 2021 Feb 23; 21(1):186. PMID: 33622270.
    Citations:    Fields:    Translation:HumansCells
  3. Denu RA, Burkard ME. Analysis of the "centrosome-ome" identifies MCPH1 deletion as a cause of centrosome amplification in human cancer. Sci Rep. 2020 07 17; 10(1):11921. PMID: 32681070.
    Citations:    Fields:    Translation:HumansCells
  4. Singh A, Denu RA, Wolfe SK, Sperger JM, Schehr J, Witkowsky T, Esbona K, Chappell RJ, Weaver BA, Burkard ME, Lang JM. Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer. Mol Oncol. 2020 08; 14(8):1898-1909. PMID: 32255253.
    Citations:    Fields:    
  5. Denu RA, Fost N. The Number of Discarded Kidneys Is Likely Much Larger Than Reported. JAMA Intern Med. 2020 03 01; 180(3):466-467. PMID: 32119043.
    Citations:    Fields:    Translation:Humans
  6. Denu RA, Patel D, Becker BJ, Shiffler T, Kleinschmidt P. MRSA Septicemia With Septic Arthritis and Prostatic, Intraretinal, Periapical, and Lung Abscesses. WMJ. 2020 Mar; 119(1):62-65. PMID: 32348075.
    Citations:    Fields:    Translation:HumansCells
  7. Denu RA, Matson DR, Davis MJ, Tedford NJ, Brichta CE, Diamond CA, Hoover-Regan ML. Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient. Case Rep Hematol. 2019; 2019:1425151. PMID: 31929920.
  8. Denu RA, Maloney J, Tomasallo CD, Jacobs NM, Krebsbach JK, Schmaling AL, Perez E, Bersch AJ, LeCaire TJ, Meiman JG, Malecki KM, LoConte NK. Survey of Radon Testing and Mitigation by Wisconsin Residents, Landlords, and School Districts. WMJ. 2019 Dec; 118(4):169-176. PMID: 31978285.
    Citations:    Fields:    Translation:HumansPHPublic Health
  9. Denu RA, Kaur G, Sass MM, Lakkaraju A, Burkard ME. Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition. Mol Cancer Res. 2020 01; 18(1):33-45. PMID: 31604847.
    Citations: 3     Fields:    Translation:HumansCells
  10. Denu RA, Sass MM, Johnson JM, Potts GK, Choudhary A, Coon JJ, Burkard ME. Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131). J Biol Chem. 2019 04 19; 294(16):6531-6549. PMID: 30804208.
    Citations: 5     Fields:    Translation:HumansCells
  11. Denu RA. Reported Biologic Differences in Breast Cancer by Race Due to Disparities in Screening. JAMA Oncol. 2018 06 01; 4(6):883. PMID: 29543935.
    Citations:    Fields:    Translation:HumansPHPublic Health
  12. Denu RA, Shabbir M, Nihal M, Singh CK, Longley BJ, Burkard ME, Ahmad N. Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma. Mol Cancer Res. 2018 03; 16(3):517-527. PMID: 29330283.
    Citations: 15     Fields:    Translation:HumansCells
  13. Denu RA, Mendonca EA, Fost N. Potential yield of imminent death kidney donation. Am J Transplant. 2018 02; 18(2):486-491. PMID: 28975705.
    Citations:    Fields:    Translation:Humans
  14. Denu RA, Hampton JM, Currey A, Anderson RT, Cress RD, Fleming ST, Lipscomb J, Wu XC, Wilson JF, Trentham-Dietz A. Racial and Socioeconomic Disparities Are More Pronounced in Inflammatory Breast Cancer Than Other Breast Cancers. J Cancer Epidemiol. 2017; 2017:7574946. PMID: 28894467.
    Citations: 1     
  15. Denu RA. SIRT3 Enhances Mesenchymal Stem Cell Longevity and Differentiation. Oxid Med Cell Longev. 2017; 2017:5841716. PMID: 28717408.
    Citations: 12     Fields:    Translation:HumansCells
  16. Denu RA. Estimates of Cancer Deaths Prevented by Raising Cigarette Taxes. JAMA Intern Med. 2017 05 01; 177(5):739. PMID: 28460094.
    Citations:    Fields:    Translation:Humans
  17. Denu RA, Rosenberg SA, Howard SP. Familial Trigeminal Neuralgia Treated with Stereotactic Radiosurgery: A Case Report and Literature Review. J Radiat Oncol. 2017 Jun; 6(2):149-152. PMID: 29201285.
    Citations: 2     
  18. Denu RA, Burkard ME. Synchronous Bilateral Breast Cancer in a Patient With Nager Syndrome. Clin Breast Cancer. 2017 06; 17(3):e151-e153. PMID: 28139434.
    Citations: 2     Fields:    Translation:Humans
  19. Denu RA, Hematti P. Effects of Oxidative Stress on Mesenchymal Stem Cell Biology. Oxid Med Cell Longev. 2016; 2016:2989076. PMID: 27413419.
    Citations: 73     Fields:    Translation:HumansCells
  20. Denu RA, Nemcek S, Bloom DD, Goodrich AD, Kim J, Mosher DF, Hematti P. Fibroblasts and Mesenchymal Stromal/Stem Cells Are Phenotypically Indistinguishable. Acta Haematol. 2016; 136(2):85-97. PMID: 27188909.
    Citations: 46     Fields:    Translation:HumansCells
  21. Denu RA, Henrich Lobo R, Mattison RJ. Management of differentiation syndrome in an elderly patient with acute promyelocytic leukemia who subsequently developed refractory anemia with ring sideroblasts. Leuk Lymphoma. 2016 12; 57(12):2905-2907. PMID: 27073113.
    Citations:    Fields:    Translation:Humans
  22. Denu RA, Zasadil LM, Kanugh C, Laffin J, Weaver BA, Burkard ME. Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer. BMC Cancer. 2016 Jan 29; 16:47. PMID: 26832928.
    Citations: 33     Fields:    Translation:HumansCells
  23. Yu W, Denu RA, Krautkramer KA, Grindle KM, Yang DT, Asimakopoulos F, Hematti P, Denu JM. Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies. J Biol Chem. 2016 Feb 12; 291(7):3268-79. PMID: 26631723.
    Citations: 33     Fields:    Translation:HumansCells
  24. Denu RA, Hampton JM, Currey A, Anderson RT, Cress RD, Fleming ST, Lipscomb J, Sabatino SA, Wu XC, Wilson JF, Trentham-Dietz A. Influence of patient, physician, and hospital characteristics on the receipt of guideline-concordant care for inflammatory breast cancer. Cancer Epidemiol. 2016 Feb; 40:7-14. PMID: 26605428.
    Citations: 3     Fields:    Translation:Humans
  25. Choudhary A, Zachek B, Lera RF, Zasadil LM, Lasek A, Denu RA, Kim H, Kanugh C, Laffin JJ, Harter JM, Wisinski KB, Saha S, Weaver BA, Burkard ME. Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. . 2016 Jan; 15(1):48-59. PMID: 26586723.
    Citations: 7     Translation:HumansCells
  26. Denu RA, Rush PS, Ahrens SE, Westergaard RP. Idiopathic CD4 lymphocytopenia with giant cell arteritis and pulmonary mucormycosis. Med Mycol Case Rep. 2014 Oct; 6:73-5. PMID: 25473601.
    Citations: 2     
  27. Asimakopoulos F, Kim J, Denu RA, Hope C, Jensen JL, Ollar SJ, Hebron E, Flanagan C, Callander N, Hematti P. Macrophages in multiple myeloma: emerging concepts and therapeutic implications. Leuk Lymphoma. 2013 Oct; 54(10):2112-21. PMID: 23432691.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  28. Kim J, Denu RA, Dollar BA, Escalante LE, Kuether JP, Callander NS, Asimakopoulos F, Hematti P. Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells. Br J Haematol. 2012 Aug; 158(3):336-46. PMID: 22583117.
    Citations: 48     Fields:    Translation:HumansCells
  29. Kim J, Breunig MJ, Escalante LE, Bhatia N, Denu RA, Dollar BA, Stein AP, Hanson SE, Naderi N, Radek J, Haughy D, Bloom DD, Assadi-Porter FM, Hematti P. Biologic and immunomodulatory properties of mesenchymal stromal cells derived from human pancreatic islets. Cytotherapy. 2012 Sep; 14(8):925-35. PMID: 22571381.
    Citations: 12     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.