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profileWilma M. Wasco, PH.D.

TitleAssociate Professor of Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMGH Ctr for Aging, Genetics & Neurodeg.
Department of Neurology
114 16th Street
Charlestown MA 02129
Phone617/726-8307
Fax617/724-1823
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AG016361     (WASCO, WILMA M.)Aug 15, 1999 - Jun 30, 2008
NIH/NIA
Calsenilin Interactions with PS2
Role: Principal Investigator

P01AG015379     (SELKOE, DENNIS J)Sep 30, 1998 - Jun 30, 2018
NIH/NIA
Presenilin Biology and the Mechanisms of Alzheimer's Disease
Role: Co-Principal Investigator

R01NS035975     (WASCO, WILMA M.)Feb 1, 1997 - Jan 31, 2000
NIH/NINDS
FUNCTIONAL ANALYSIS OF AD-LINKED PRESENILIN 2 MUTATIONS
Role: Principal Investigator

R01AG011899     (WASCO, WILMA M.)Jan 1, 1994 - Dec 31, 1996
NIH/NIA
APP-RELATED GENES AND ALZHEIMER'S DISEASE
Role: Principal Investigator

F32GM012160     (WASCO, WILMA M.)Mar 14, 1988
NIH/NIGMS
MOLECULAR CHARACTERIZATION OF THE CHARTIN FAMILY OF
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bonini NM, Lee EB, Wasco W, Roses AD. Editorial overview: Molecular & genetic basis of disease. Curr Opin Genet Dev. 2017 Jun; 44:iv-vi. PMID: 28473186.
    View in: PubMed
  2. Li A, Ahsen OO, Liu JJ, Du C, McKee ML, Yang Y, Wasco W, Newton-Cheh CH, O'Donnell CJ, Fujimoto JG, Zhou C, Tanzi RE. Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography. Hum Mol Genet. 2013 Sep 15; 22(18):3798-806. PMID: 23696452; PMCID: PMC3749865.
  3. Jang C, Choi JK, Na YJ, Jang B, Wasco W, Buxbaum JD, Kim YS, Choi EK. Calsenilin regulates presenilin 1/?-secretase-mediated N-cadherin e-cleavage and ß-catenin signaling. FASEB J. 2011 Dec; 25(12):4174-83. PMID: 21852538.
    View in: PubMed
  4. Myre MA, Lumsden AL, Thompson MN, Wasco W, MacDonald ME, Gusella JF. Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideum. PLoS Genet. 2011 Apr; 7(4):e1002052. PMID: 21552328; PMCID: PMC3084204.
  5. Jang C, Choi JK, Kim E, Park ES, Wasco W, Buxbaum JD, Kim YS, Choi EK. Calsenilin is degraded by the ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 2011 Feb 11; 405(2):180-5. PMID: 21216226.
    View in: PubMed
  6. Myre MA, Washicosky K, Moir RD, Tesco G, Tanzi RE, Wasco W. Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1. Cell Signal. 2009 Apr; 21(4):567-76. PMID: 19154786; PMCID: PMC3701301.
  7. Haverkamp S, Specht D, Majumdar S, Zaidi NF, Brandstätter JH, Wasco W, Wässle H, Tom Dieck S. Type 4 OFF cone bipolar cells of the mouse retina express calsenilin and contact cones as well as rods. J Comp Neurol. 2008 Mar 01; 507(1):1087-101. PMID: 18095322.
    View in: PubMed
  8. Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ. The APP family of proteins: similarities and differences. Biochem Soc Trans. 2007 Apr; 35(Pt 2):416-20. PMID: 17371289.
    View in: PubMed
  9. Zaidi NF, Kuplast KG, Washicosky KJ, Kajiwara Y, Buxbaum JD, Wasco W. Calsenilin interacts with transcriptional co-repressor C-terminal binding protein(s). J Neurochem. 2006 Aug; 98(4):1290-301. PMID: 16787403.
    View in: PubMed
  10. Jin JK, Choi JK, Wasco W, Buxbaum JD, Kozlowski PB, Carp RI, Kim YS, Choi EK. Expression of calsenilin in neurons and astrocytes in the Alzheimer's disease brain. Neuroreport. 2005 Apr 04; 16(5):451-5. PMID: 15770150.
    View in: PubMed
  11. Zaidi NF, Thomson EE, Choi EK, Buxbaum JD, Wasco W. Intracellular calcium modulates the nuclear translocation of calsenilin. J Neurochem. 2004 May; 89(3):593-601. PMID: 15086516.
    View in: PubMed
  12. Lilliehook C, Bozdagi O, Yao J, Gomez-Ramirez M, Zaidi NF, Wasco W, Gandy S, Santucci AC, Haroutunian V, Huntley GW, Buxbaum JD. Altered Abeta formation and long-term potentiation in a calsenilin knock-out. J Neurosci. 2003 Oct 08; 23(27):9097-106. PMID: 14534243.
    View in: PubMed
  13. Choi EK, Miller JS, Zaidi NF, Salih E, Buxbaum JD, Wasco W. Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3. Mol Cell Neurosci. 2003 Jul; 23(3):495-506. PMID: 12837631.
    View in: PubMed
  14. Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 2003 Jun 10; 42(22):6664-73. PMID: 12779321.
    View in: PubMed
  15. Lilliehook C, Chan S, Choi EK, Zaidi NF, Wasco W, Mattson MP, Buxbaum JD. Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. Mol Cell Neurosci. 2002 Apr; 19(4):552-9. PMID: 11988022.
    View in: PubMed
  16. Zaidi NF, Berezovska O, Choi EK, Miller JS, Chan H, Lilliehook C, Hyman BT, Buxbaum JD, Wasco W. Biochemical and immunocytochemical characterization of calsenilin in mouse brain. Neuroscience. 2002; 114(1):247-63. PMID: 12207970.
    View in: PubMed
  17. Wasco W and Fausett HJ. Central Pain. Manual of Pain Management. 2002; 189-192.
  18. Tekirian TL, Merriam DE, Marshansky V, Miller J, Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W. Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments. Brain Res Mol Brain Res. 2001 Nov 30; 96(1-2):14-20. PMID: 11731004.
    View in: PubMed
  19. Osawa M, Tong KI, Lilliehook C, Wasco W, Buxbaum JD, Cheng HY, Penninger JM, Ikura M, Ames JB. Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3. J Biol Chem. 2001 Nov 02; 276(44):41005-13. PMID: 11535596.
    View in: PubMed
  20. Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W. Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. J Biol Chem. 2001 Jun 01; 276(22):19197-204. PMID: 11278424.
    View in: PubMed
  21. Wasco W. Molecular Genetics of Alzheimers Disease. In Neurobiology of Alzheimer's Disease. 2001; 52-74.
  22. Buxbaum JD, Lilliehook C, Chan JY, Go RC, Bassett SS, Tanzi RE, Wasco W, Blacker D. Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease. Neurosci Lett. 2000 Nov 24; 294(3):135-8. PMID: 11072133.
    View in: PubMed
  23. Leissring MA, Yamasaki TR, Wasco W, Buxbaum JD, Parker I, LaFerla FM. Calsenilin reverses presenilin-mediated enhancement of calcium signaling. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8590-3. PMID: 10900016; PMCID: PMC26992.
  24. Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med. 1998 Oct; 4(10):1177-81. PMID: 9771752.
    View in: PubMed
  25. McNamara MJ, Ruff CT, Wasco W, Tanzi RE, Thinakaran G, Hyman BT. Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains. Brain Res. 1998 Aug 31; 804(1):45-51. PMID: 9729270.
    View in: PubMed
  26. Wasco W. Molecular Biology of Presenilin 2. Molecular Biology of Alzheimer's Disease. 1998; 207-218.
  27. Wasco W. Amyloid ß-protein precursor. Human Protein Data. 1998.
  28. Gómez-Isla T, Wasco W, Pettingell WP, Gurubhagavatula S, Schmidt SD, Jondro PD, McNamara M, Rodes LA, DiBlasi T, Growdon WB, Seubert P, Schenk D, Growdon JH, Hyman BT, Tanzi RE. A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes. Ann Neurol. 1997 Jun; 41(6):809-13. PMID: 9189043.
    View in: PubMed
  29. Kim TW, Pettingell WH, Hallmark OG, Moir RD, Wasco W, Tanzi RE. Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. J Biol Chem. 1997 Apr 25; 272(17):11006-10. PMID: 9110991.
    View in: PubMed
  30. Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y. Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry. 1997 Apr 15; 36(15):4643-9. PMID: 9109675.
    View in: PubMed
  31. Berezovska O, Xia MQ, Page K, Wasco W, Tanzi RE, Hyman BT. Developmental regulation of presenilin mRNA expression parallels notch expression. J Neuropathol Exp Neurol. 1997 Jan; 56(1):40-4. PMID: 8990127.
    View in: PubMed
  32. Johnston JA, Norgren S, Ravid R, Wasco W, Winblad B, Lannfelt L, Cowburn RF. Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brains. Brain Res Mol Brain Res. 1996 Dec 31; 43(1-2):85-95. PMID: 9037522.
    View in: PubMed
  33. Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacanà E, Sunderland T, Zhao B, Kusiak JW, Wasco W, D'Adamio L. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science. 1996 Dec 06; 274(5293):1710-3. PMID: 8939861.
    View in: PubMed
  34. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med. 1996 Aug; 2(8):864-70. PMID: 8705854.
    View in: PubMed
  35. Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med. 1996 Feb; 2(2):224-9. PMID: 8574969.
    View in: PubMed
  36. Wasco W and Tanzi RE. Etiological clues from gene defects causing early-onset familial Alzheimer's disease. Molecular Models of Dementia. 1996; 1-20.
  37. Tanzi RE, Kovacs DM, Kim TW, Moir RD, Guenette SY, Wasco W. The gene defects responsible for familial Alzheimer's disease. Neurobiol Dis. 1996; 3(3):159-68. PMID: 8980016.
    View in: PubMed
  38. Tanzi, R.E., Kovacs, D.M., Kim, T.-W., Moir, R.D., Guénette, S.Y. and Wasco, W. . The presenilin genes and their role in early-onset Alzheimer's disease. Alzheimer's Disease Review. 1996; 1:90-98.
  39. Kovacs DM, Wasco W, Witherby J, Felsenstein KM, Brunel F, Roeder RG, Tanzi RE. The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene. Hum Mol Genet. 1995 Sep; 4(9):1527-33. PMID: 8541835.
    View in: PubMed
  40. Wasco W, Pettingell WP, Jondro PD, Schmidt SD, Gurubhagavatula S, Rodes L, DiBlasi T, Romano DM, Guenette SY, Kovacs DM, et al. Familial Alzheimer's chromosome 14 mutations. Nat Med. 1995 Sep; 1(9):848. PMID: 7585193.
    View in: PubMed
  41. Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu CE, Jondro PD, Schmidt SD, Wang K, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science. 1995 Aug 18; 269(5226):973-7. PMID: 7638622.
    View in: PubMed
  42. Webster MT, Groome N, Francis PT, Pearce BR, Sherriff FE, Thinakaran G, Felsenstein KM, Wasco W, Tanzi RE, Bowen DM. A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media. Biochem J. 1995 Aug 15; 310 ( Pt 1):95-9. PMID: 7646477; PMCID: PMC1135859.
  43. Kim TW, Wu K, Xu JL, McAuliffe G, Tanzi RE, Wasco W, Black IB. Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. Brain Res Mol Brain Res. 1995 Aug; 32(1):36-44. PMID: 7494461.
    View in: PubMed
  44. Wasco, W and Tanzi, RE. Molecular genetics of amyloid and apolipoprotein E in Alzheimer's disease. Neurobiology of Alzheimer's Disease. 1995; 51-76.
  45. Bush AI, Pettingell WH, de Paradis M, Tanzi RE, Wasco W. The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. J Biol Chem. 1994 Oct 28; 269(43):26618-21. PMID: 7929392.
    View in: PubMed
  46. Ali G, Wasco W, Cai X, Szabo P, Sheu KF, Cooper AJ, Gaston SM, Gusella JF, Tanzi RE, Blass JP. Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex. Somat Cell Mol Genet. 1994 Mar; 20(2):99-105. PMID: 8009371.
    View in: PubMed
  47. Tanzi RE, Bush AI, Wasco W. Genetic studies of Alzheimer's disease: lessons learned and future imperatives. Neurobiol Aging. 1994; 15 Suppl 2:S145-8. PMID: 7700440.
    View in: PubMed
  48. Tanzi, R., Romano, D., Gaston, S., Crowley, A., Bush, A., Peppercorn, J., Paradis, M., Pettingell, W., Gurubhagavatula, S., Kovacs, D., Haines, J., St George-Hyslop, P., and Wasco, W. . The diverse molecular nature of inherited Alzheimer's disease. Amyloid precursor protein in development, aging and Alzheimer's disease,. 1994; 180-189.
  49. Tanzi RE, Petrukhin K, Chernov I, Pellequer JL, Wasco W, Ross B, Romano DM, Parano E, Pavone L, Brzustowicz LM, et al. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nat Genet. 1993 Dec; 5(4):344-50. PMID: 8298641.
    View in: PubMed
  50. Wasco W, Peppercorn J, Tanzi RE. Search for the genes responsible for familial Alzheimer's disease. Ann N Y Acad Sci. 1993 Sep 24; 695:203-8. PMID: 8239284.
    View in: PubMed
  51. Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL, Tanzi RE. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat Genet. 1993 Sep; 5(1):95-100. PMID: 8220435.
    View in: PubMed
  52. Wasco W, Brook JD, Tanzi RE. The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. Genomics. 1993 Jan; 15(1):237-9. PMID: 8432545.
    View in: PubMed
  53. Tanzi R, Gaston S, Bush A, Romano D, Pettingell W, Peppercorn J, Paradis M, Gurubhagavatula S, Jenkins B, Wasco W. Genetic heterogeneity of gene defects responsible for familial Alzheimer disease. Genetica. 1993; 91(1-3):255-63. PMID: 8125274.
    View in: PubMed
  54. Wasco W, Bupp K, Magendantz M, Gusella JF, Tanzi RE, Solomon F. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10758-62. PMID: 1279693; PMCID: PMC50421.
  55. Tanzi RE, Vaula G, Romano DM, Mortilla M, Huang TL, Tupler RG, Wasco W, Hyman BT, Haines JL, Jenkins BJ, et al. Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. Am J Hum Genet. 1992 Aug; 51(2):273-82. PMID: 1642228; PMCID: PMC1682666.
  56. Bulawa CE, Wasco W. Chitin and nodulation. Nature. 1991 Oct 24; 353(6346):710. PMID: 1834944.
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  57. Horowitz JA, Voulalas P, Wasco W, MacLeod J, Paupard MC, Orr GA. Biochemical and immunological characterization of the flagellar-associated regulatory subunit of a type II cyclic adenosine 5'-monophosphate-dependent protein kinase. Arch Biochem Biophys. 1989 May 01; 270(2):411-8. PMID: 2650622.
    View in: PubMed
  58. Wasco WM, Kincaid RL, Orr GA. Identification and characterization of calmodulin-binding proteins in mammalian sperm flagella. J Biol Chem. 1989 Mar 25; 264(9):5104-11. PMID: 2538474.
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  59. Lieberman SJ, Wasco W, MacLeod J, Satir P, Orr GA. Immunogold localization of the regulatory subunit of a type II cAMP-dependent protein kinase tightly associated with mammalian sperm flagella. J Cell Biol. 1988 Nov; 107(5):1809-16. PMID: 2972731; PMCID: PMC2115342.
  60. Paupard MC, MacLeod J, Wasco W, Orr GA. Major 56,000-dalton, soluble phosphoprotein present in bovine sperm is the regulatory subunit of a type II cAMP-dependent protein kinase. J Cell Biochem. 1988 Jun; 37(2):161-75. PMID: 3397399.
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  61. Horowitz JA, Wasco W, Leiser M, Orr GA. Interaction of the regulatory subunit of a type II cAMP-dependent protein kinase with mammalian sperm flagellum. J Biol Chem. 1988 Feb 05; 263(4):2098-104. PMID: 3276682.
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  62. Wilma Wasco. Regulation of Sperm Motility by Calcium and Calmodulin. 1987.
  63. Wasco WM, Orr GA. Function of calmodulin in mammalian sperm: presence of a calmodulin-dependent cyclic nucleotide phosphodiesterase associated with demembranated rat caudal epididymal sperm. Biochem Biophys Res Commun. 1984 Jan 30; 118(2):636-42. PMID: 6322756.
    View in: PubMed
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