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Emmanuel Jean-Marie Mignot, Ph.D., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P50NS023724 (MIGNOT, EMMANUEL J) Apr 1, 2016 - May 31, 2016
    NIH/NINDS
    Center for Narcolepsy and Related Disorders (P50)
    Role: Principal Investigator
  2. T32HL110952 (PACK, ALLAN I) Jul 13, 2013 - Jun 30, 2023
    NIH/NHLBI
    Multi-Institutional Training in Genetic/Genomic Approaches to Sleep Disorders
    Role: Co-Principal Investigator
  3. U01NS073581 (MIGNOT, EMMANUEL J) Aug 15, 2010 - Apr 30, 2014
    NIH/NINDS
    HLA-DQ Sequencing Studies in Narcolepsy/Hypocretin Deficiency
    Role: Principal Investigator
  4. R01NS062798 (MOURRAIN, PHILIPPE) Jul 1, 2008 - Jun 30, 2014
    NIH/NINDS
    Sleep promotion in zebrafish by hypocretin neuronal networks
    Role: Co-Principal Investigator
  5. R01MH080957 (MIGNOT, EMMANUEL J) Sep 15, 2007 - May 31, 2013
    NIH/NIMH
    Molecular Genetics of Kleine-Levin Syndrome
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cheung J, Leary EB, Lu H, Zeitzer JM, Mignot E. PSG Validation of minute-to-minute scoring for sleep and wake periods in a consumer wearable device. PLoS One. 2020; 15(9):e0238464. PMID: 32941498.
    Citations:    
  2. Olesen AN, Jennum PJ, Mignot E, Sorensen HBD. Automatic sleep stage classification with deep residual networks in a mixed-cohort setting. Sleep. 2020 Aug 26. PMID: 32844179.
    Citations:    
  3. Maresca A, Del Dotto V, Capristo M, Scimonelli E, Tagliavini F, Morandi L, Tropeano CV, Caporali L, Mohamed S, Roberti M, Scandiffio L, Zaffagnini M, Rossi J, Cappelletti M, Musiani F, Contin M, Riva R, Liguori R, Pizza F, La Morgia C, Antelmi E, Loguercio Polosa P, Mignot E, Zanna C, Plazzi G, Carelli V. DNMT1 mutations leading to neurodegeneration paradoxically reflect on mitochondrial metabolism. Hum Mol Genet. 2020 Jul 21; 29(11):1864-1881. PMID: 31984424.
    Citations:    
  4. Scammell TE, Luo G, Borker P, Sullivan L, Biddle K, Mignot E. Treatment of narcolepsy with natalizumab. Sleep. 2020 Jul 13; 43(7). PMID: 32249922.
    Citations:    
  5. Mignot E, Black S. Narcolepsy risk and COVID-19. J Clin Sleep Med. 2020 Jul 06. PMID: 32621581.
    Citations:    
  6. Leary EB, Watson KT, Ancoli-Israel S, Redline S, Yaffe K, Ravelo LA, Peppard PE, Zou J, Goodman SN, Mignot E, Stone KL. Association of Rapid Eye Movement Sleep With Mortality in Middle-aged and Older Adults. JAMA Neurol. 2020 Jul 06. PMID: 32628261.
    Citations:    
  7. Brink-Kjaer A, Mignot E, Sorensen HBD, Jennum P. Predicting Age with Deep Neural Networks from Polysomnograms. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:146-149. PMID: 33017951.
    Citations:    
  8. Hanif U, Paulsen RR, Leary EB, Mignot E, Jennum P, Sorensen HBD. Prediction of Patient Demographics using 3D Craniofacial Scans and Multi-view CNNs. Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul; 2020:1950-1953. PMID: 33018384.
    Citations:    
  9. Olesen AN, Jennum P, Mignot E, Sorensen HBD. Deep transfer learning for improving single-EEG arousal detection. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:99-103. PMID: 33017940.
    Citations:    
  10. Olsen M, Mignot E, Jennum PJ, Sorensen HBD. Robust, ECG-based detection of Sleep-disordered breathing in large population-based cohorts. Sleep. 2020 May 12; 43(5). PMID: 31738833.
    Citations:    
  11. Maski K, Mignot E, Scammell TE. COMMENTARY on Lammers et al, Diagnosis of central disorders of hypersomnolence: Challenges in defining central disorders of hypersomnolence. Sleep Med Rev. 2020 08; 52:101327. PMID: 32554241.
    Citations:    
  12. Ambati A, Ju YE, Lin L, Olesen AN, Koch H, Hedou JJ, Leary EB, Sempere VP, Mignot E, Taheri S. Proteomic biomarkers of sleep apnea. Sleep. 2020 May 05. PMID: 32369590.
    Citations:    
  13. Brink-Kjaer A, Olesen AN, Peppard PE, Stone KL, Jennum P, Mignot E, Sorensen HBD. Automatic detection of cortical arousals in sleep and their contribution to daytime sleepiness. Clin Neurophysiol. 2020 Jun; 131(6):1187-1203. PMID: 32299002.
    Citations:    
  14. Muñiz-Castrillo S, Ambati A, Dubois V, Vogrig A, Joubert B, Rogemond V, Picard G, Lin L, Fabien N, Mignot E, Honnorat J. Primary DQ effect in the association between HLA and neurological syndromes with anti-GAD65 antibodies. J Neurol. 2020 Jul; 267(7):1906-1911. PMID: 32152690.
    Citations:    
  15. Carvelli L, Olesen AN, Brink-Kjær A, Leary EB, Peppard PE, Mignot E, Sørensen HBD, Jennum P. Design of a deep learning model for automatic scoring of periodic and non-periodic leg movements during sleep validated against multiple human experts. Sleep Med. 2020 05; 69:109-119. PMID: 32062037.
    Citations:    
  16. Vandi S, Rodolfi S, Pizza F, Moresco M, Antelmi E, Ferri R, Mignot E, Plazzi G, Silvani A. Cardiovascular autonomic dysfunction, altered sleep architecture, and muscle overactivity during nocturnal sleep in pediatric patients with narcolepsy type 1. Sleep. 2019 12 24; 42(12). PMID: 31353416.
    Citations:    
  17. Ravel JM, Mignot EJM. [Narcolepsy: From the discovery of a wake promoting peptide to autoimmune T?cell biology and molecular mimicry with flu epitopes]. Biol Aujourdhui. 2019; 213(3-4):87-108. PMID: 31829930.
    Citations:    
  18. Pizza F, Barateau L, Jaussent I, Vandi S, Antelmi E, Mignot E, Dauvilliers Y, Plazzi G. Validation of Multiple Sleep Latency Test for the diagnosis of pediatric narcolepsy type 1. Neurology. 2019 09 10; 93(11):e1034-e1044. PMID: 31405906.
    Citations:    
  19. Olesen AN, Chambon S, Thorey V, Jennum P, Mignot E, Sorensen HBD. Towards a Flexible Deep Learning Method for Automatic Detection of Clinically Relevant Multi-Modal Events in the Polysomnogram. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:556-561. PMID: 31945960.
    Citations:    
  20. Hershner S, Dauvilliers Y, Chung F, Singh M, Wong J, Gali B, Kakkar R, Mignot E, Thorpy M, Auckley D. Knowledge Gaps in the Perioperative Management of Adults With Narcolepsy: A Call for Further Research. Anesth Analg. 2019 07; 129(1):204-211. PMID: 30882519.
    Citations:    
  21. Kim SJ, Kim S, Jeon S, Leary EB, Barwick F, Mignot E. Factors associated with fatigue in patients with insomnia. J Psychiatr Res. 2019 10; 117:24-30. PMID: 31272015.
    Citations:    
  22. Edwards K, Hanquet G, Black S, Mignot E, Jankosky C, Shimabukuro T, Miller E, Nohynek H, Neels P. Meeting report narcolepsy and pandemic influenza vaccination: What we know and what we need to know before the next pandemic? A report from the 2nd IABS meeting. Biologicals. 2019 Jul; 60:1-7. PMID: 31130313.
    Citations:    
  23. Mignot E, Ambati A, Luo G. Response to "H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls". J Neuroimmunol. 2019 08 15; 333:476959. PMID: 31108400.
    Citations:    
  24. Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW. The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science. 2019 04 12; 364(6436). PMID: 30975860.
    Citations:    
  25. Chambon S, Thorey V, Arnal PJ, Mignot E, Gramfort A. DOSED: A deep learning approach to detect multiple sleep micro-events in EEG signal. J Neurosci Methods. 2019 06 01; 321:64-78. PMID: 30946878.
    Citations:    
  26. Hanif U, Schneider LD, Trap L, Leary EB, Moore H, Guilleminault C, Jennum P, Sorensen HBD, Mignot EJM. Non-invasive machine learning estimation of effort differentiates sleep-disordered breathing pathology. Physiol Meas. 2019 02 26; 40(2):025008. PMID: 30736016.
    Citations:    
  27. Sakai N, Matsumura M, Lin L, Mignot E, Nishino S. HPLC analysis of CSF hypocretin-1 in type 1 and 2 narcolepsy. Sci Rep. 2019 01 24; 9(1):477. PMID: 30679597.
    Citations:    
  28. Luo G, Ambati A, Lin L, Bonvalet M, Partinen M, Ji X, Maecker HT, Mignot EJ. Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12323-E12332. PMID: 30541895.
    Citations:    
  29. Stephansen JB, Olesen AN, Olsen M, Ambati A, Leary EB, Moore HE, Carrillo O, Lin L, Han F, Yan H, Sun YL, Dauvilliers Y, Scholz S, Barateau L, Hogl B, Stefani A, Hong SC, Kim TW, Pizza F, Plazzi G, Vandi S, Antelmi E, Perrin D, Kuna ST, Schweitzer PK, Kushida C, Peppard PE, Sorensen HBD, Jennum P, Mignot E. Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy. Nat Commun. 2018 12 06; 9(1):5229. PMID: 30523329.
    Citations:    
  30. Leary EB, Moore HE, Schneider LD, Finn LA, Peppard PE, Mignot E. Periodic limb movements in sleep: Prevalence and associated sleepiness in the Wisconsin Sleep Cohort. Clin Neurophysiol. 2018 11; 129(11):2306-2314. PMID: 30243181.
    Citations:    
  31. Olesen AN, Jennum P, Peppard P, Mignot E, Sorensen HBD. Deep residual networks for automatic sleep stage classification of raw polysomnographic waveforms. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:1-4. PMID: 30440296.
    Citations:    
  32. Plazzi G, Ruoff C, Lecendreux M, Dauvilliers Y, Rosen CL, Black J, Parvataneni R, Guinta D, Wang YG, Mignot E. Treatment of paediatric narcolepsy with sodium oxybate: a double-blind, placebo-controlled, randomised-withdrawal multicentre study and open-label investigation. Lancet Child Adolesc Health. 2018 07; 2(7):483-494. PMID: 30169321.
    Citations:    
  33. Wang W, Ollila HM, Whittemore AS, Demehri S, Ioannidis NM, Jorgenson E, Mignot E, Asgari MM. Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma. Cancer Immunol Immunother. 2018 Jul; 67(7):1123-1133. PMID: 29754218.
    Citations:    Fields:    
  34. Olsen M, Schneider LD, Cheung J, Peppard PE, Jennum PJ, Mignot E, Sorensen HBD. Automatic, electrocardiographic-based detection of autonomic arousals and their association with cortical arousals, leg movements, and respiratory events in sleep. Sleep. 2018 03 01; 41(3). PMID: 29329416.
    Citations:    
  35. Cheung J, Ruoff C, Moore H, Hagerman KA, Perez J, Sakamuri S, Warby SC, Mignot E, Day J, Sampson J. Increased EEG Theta Spectral Power in Sleep in Myotonic Dystrophy Type 1. J Clin Sleep Med. 2018 02 15; 14(2):229-235. PMID: 29394960.
    Citations:    
  36. Ruoff C, Pizza F, Trotti LM, Sonka K, Vandi S, Cheung J, Pinto S, Einen M, Simakajornboon N, Han F, Peppard P, Nevsimalova S, Plazzi G, Rye D, Mignot E. The MSLT is Repeatable in Narcolepsy Type 1 But Not Narcolepsy Type 2: A Retrospective Patient Study. J Clin Sleep Med. 2018 01 15; 14(1):65-74. PMID: 29198301.
    Citations:    
  37. Moresco M, Lecciso M, Ocadlikova D, Filardi M, Melzi S, Kornum BR, Antelmi E, Pizza F, Mignot E, Curti A, Plazzi G. Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease. Sleep Med. 2018 04; 44:53-60. PMID: 29530370.
    Citations:    
  38. Olesen AN, Cesari M, Christensen JAE, Sorensen HBD, Mignot E, Jennum P. A comparative study of methods for automatic detection of rapid eye movement abnormal muscular activity in narcolepsy. Sleep Med. 2018 04; 44:97-105. PMID: 29530376.
    Citations:    
  39. Hillary RP, Ollila HM, Lin L, Desestret V, Rogemond V, Picard G, Small M, Arnulf I, Dauvilliers Y, Honnorat J, Mignot E. Complex HLA association in paraneoplastic cerebellar ataxia with anti-Yo antibodies. J Neuroimmunol. 2018 02 15; 315:28-32. PMID: 29306402.
    Citations: 1     Fields:    
  40. Luo G, Lin L, Jacob L, Bonvalet M, Ambati A, Plazzi G, Pizza F, Leib R, Adams CM, Partinen M, Mignot EJ. Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases. PLoS One. 2017; 12(12):e0187305. PMID: 29220370.
    Citations:    
  41. Belbezier A, Joubert B, Montero-Martin G, Fernandez-Vina M, Fabien N, Rogemond V, Mignot E, Honnorat J. Multiplex family with GAD65-Abs neurologic syndromes. Neurol Neuroimmunol Neuroinflamm. 2018 Jan; 5(1):e416. PMID: 29379821.
    Citations:    
  42. Bonvalet M, Ollila HM, Ambati A, Mignot E. Autoimmunity in narcolepsy. Curr Opin Pulm Med. 2017 11; 23(6):522-529. PMID: 28991006.
    Citations: 3     Fields:    Translation:HumansCells
  43. Koch H, Schneider LD, Finn LA, Leary EB, Peppard PE, Hagen E, Sorensen HBD, Jennum P, Mignot E. Breathing Disturbances Without Hypoxia Are Associated With Objective Sleepiness in Sleep Apnea. Sleep. 2017 11 01; 40(11). PMID: 29029253.
    Citations:    
  44. Schneider L, Mignot E. Diagnosis and Management of Narcolepsy. Semin Neurol. 2017 08; 37(4):446-460. PMID: 28837992.
    Citations:    
  45. Ju YS, Ooms SJ, Sutphen C, Macauley SL, Zangrilli MA, Jerome G, Fagan AM, Mignot E, Zempel JM, Claassen JAHR, Holtzman DM. Slow wave sleep disruption increases cerebrospinal fluid amyloid-ß levels. Brain. 2017 Aug 01; 140(8):2104-2111. PMID: 28899014.
    Citations: 4     Fields:    Translation:Humans
  46. Olsen AV, Stephansen J, Leary E, Peppard PE, Sheungshul H, Jennum PJ, Sorensen H, Mignot E. Diagnostic value of sleep stage dissociation as visualized on a 2-dimensional sleep state space in human narcolepsy. J Neurosci Methods. 2017 Apr 15; 282:9-19. PMID: 28219726.
    Citations:    
  47. Goldberg S, Ollila HM, Lin L, Sharifi H, Rico T, Andlauer O, Aran A, Bloomrosen E, Faraco J, Fang H, Mignot E. Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers. PLoS One. 2017; 12(1):e0168930. PMID: 28045995.
    Citations:    Fields:    Translation:Humans
  48. Nguyen QT, Groos E, Leclair-Visonneau L, Monaca-Charley C, Rico T, Farber N, Mignot E, Arnulf I. Familial Kleine-Levin Syndrome: A Specific Entity? Sleep. 2016 Aug 01; 39(8):1535-42. PMID: 27253765.
    Citations:    
  49. Gavrilov YV, Ellison BA, Yamamoto M, Reddy H, Haybaeck J, Mignot E, Baumann CR, Scammell TE, Valko PO. Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area. Sleep. 2016 05 01; 39(5):1059-62. PMID: 26951397.
    Citations: 1     Fields:    Translation:HumansCells
  50. Plante DT, Finn LA, Hagen EW, Mignot E, Peppard PE. Subjective and Objective Measures of Hypersomnolence Demonstrate Divergent Associations with Depression among Participants in the Wisconsin Sleep Cohort Study. J Clin Sleep Med. 2016 Apr 15; 12(4):571-8. PMID: 26888592.
    Citations:    
  51. Blackman A, Foster GD, Zammit G, Rosenberg R, Aronne L, Wadden T, Claudius B, Jensen CB, Mignot E. Effect of liraglutide 3.0?mg in individuals with obesity and moderate or severe obstructive sleep apnea: the SCALE Sleep Apnea randomized clinical trial. Int J Obes (Lond). 2016 08; 40(8):1310-9. PMID: 27005405.
    Citations:    
  52. Jacob L, Mignot E. [Not Available]. Hist Sci Med. 2016 Jan-Mar; 50(1):69-74. PMID: 27349127.
    Citations:    
  53. Kawai M, O'Hara R, Einen M, Lin L, Mignot E. Narcolepsy in African Americans. Sleep. 2015 Nov 01; 38(11):1673-81. PMID: 26158891.
    Citations:    
  54. Christensen JA, Munk EG, Peppard PE, Young T, Mignot E, Sorensen HB, Jennum P. The diagnostic value of power spectra analysis of the sleep electroencephalography in narcoleptic patients. Sleep Med. 2015 Dec; 16(12):1516-27. PMID: 26611950.
    Citations:    
  55. Moore H, Leary E, Lee SY, Carrillo O, Stubbs R, Peppard P, Young T, Widrow B, Mignot E. Correction: Design and Validation of a Periodic Leg Movement Detector. PLoS One. 2015; 10(9):e0138205. PMID: 26356080.
    Citations:    
  56. Pizza F, Vandi S, Iloti M, Franceschini C, Liguori R, Mignot E, Plazzi G. Nocturnal Sleep Dynamics Identify Narcolepsy Type 1. Sleep. 2015 Aug 01; 38(8):1277-84. PMID: 25845690.
    Citations:    
  57. Christensen JA, Carrillo O, Leary EB, Peppard PE, Young T, Sorensen HB, Jennum P, Mignot E. Sleep-stage transitions during polysomnographic recordings as diagnostic features of type 1 narcolepsy. Sleep Med. 2015 Dec; 16(12):1558-66. PMID: 26299470.
    Citations:    
  58. Li J, Moore H, Lin L, Young T, Finn L, Peppard PE, Mignot E. Association of low ferritin with PLM in the Wisconsin Sleep Cohort. Sleep Med. 2015 Nov; 16(11):1413-1418. PMID: 26498245.
    Citations:    
  59. Mignot EJ. Erratum to: History of narcolepsy at Stanford University. Immunol Res. 2015 Jun; 62(2):253. PMID: 25948476.
    Citations:    
  60. Kornum BR, Rico T, Lin L, Huang YS, Arnulf I, Jennum P, Mignot E. Serum cytokine levels in Kleine-Levin syndrome. Sleep Med. 2015 Aug; 16(8):961-5. PMID: 26116465.
    Citations:    
  61. Christensen JA, Nikolic M, Warby SC, Koch H, Zoetmulder M, Frandsen R, Moghadam KK, Sorensen HB, Mignot E, Jennum PJ. Sleep spindle alterations in patients with Parkinson's disease. Front Hum Neurosci. 2015; 9:233. PMID: 25983685.
    Citations:    
  62. Kornum BR, Pizza F, Knudsen S, Plazzi G, Jennum P, Mignot E. Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset. Brain Behav Immun. 2015 Oct; 49:54-8. PMID: 25771509.
    Citations:    
  63. Holm A, Lin L, Faraco J, Mostafavi S, Battle A, Zhu X, Levinson DF, Han F, Gammeltoft S, Jennum P, Mignot E, Kornum BR. EIF3G is associated with narcolepsy across ethnicities. Eur J Hum Genet. 2015 Nov; 23(11):1573-80. PMID: 25669430.
    Citations:    
  64. Ollila HM, Ravel JM, Han F, Faraco J, Lin L, Zheng X, Plazzi G, Dauvilliers Y, Pizza F, Hong SC, Jennum P, Knudsen S, Kornum BR, Dong XS, Yan H, Hong H, Coquillard C, Mahlios J, Jolanki O, Einen M, Arnulf I, Lavault S, Högl B, Frauscher B, Crowe C, Partinen M, Huang YS, Bourgin P, Vaarala O, Désautels A, Montplaisir J, Mack SJ, Mindrinos M, Fernandez-Vina M, Mignot E. HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy. Am J Hum Genet. 2015 Jan 08; 96(1):136-46. PMID: 25574827.
    Citations: 16     Fields:    Translation:HumansCells
  65. Ollila HM, Fernandez-Vina M, Mignot E. HLA-DQ allele competition in narcolepsy: a comment on Tafti et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe. Sleep. 2015 Jan 01; 38(1):147-51. PMID: 25325462.
    Citations: 2     Fields:    Translation:Humans
  66. Moore H, Leary E, Lee SY, Carrillo O, Stubbs R, Peppard P, Young T, Widrow B, Mignot E. Design and validation of a periodic leg movement detector. PLoS One. 2014; 9(12):e114565. PMID: 25489744.
    Citations:    
  67. Jacob L, Leib R, Ollila HM, Bonvalet M, Adams CM, Mignot E. Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development. Brain Behav Immun. 2015 Jul; 47:44-57. PMID: 25452148.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  68. Wendt SL, Welinder P, Sorensen HB, Peppard PE, Jennum P, Perona P, Mignot E, Warby SC. Inter-expert and intra-expert reliability in sleep spindle scoring. Clin Neurophysiol. 2015 Aug; 126(8):1548-56. PMID: 25434753.
    Citations:    
  69. Pizza F, Vandi S, Liguori R, Parchi P, Avoni P, Mignot E, Plazzi G. Primary progressive narcolepsy type 1: the other side of the coin. Neurology. 2014 Dec 02; 83(23):2189-90. PMID: 25355832.
    Citations:    
  70. Han F, Lin L, Schormair B, Pizza F, Plazzi G, Ollila HM, Nevsimalova S, Jennum P, Knudsen S, Winkelmann J, Coquillard C, Babrzadeh F, Strom TM, Wang C, Mindrinos M, Fernandez Vina M, Mignot E. HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency. Sleep. 2014 Oct 01; 37(10):1601-8. PMID: 25197808.
    Citations: 12     Fields:    Translation:Humans
  71. Montplaisir J, Petit D, Quinn MJ, Ouakki M, Deceuninck G, Desautels A, Mignot E, De Wals P. Risk of narcolepsy associated with inactivated adjuvanted (AS03) A/H1N1 (2009) pandemic influenza vaccine in Quebec. PLoS One. 2014; 9(9):e108489. PMID: 25264897.
    Citations:    
  72. Canellas F, Lin L, Julià MR, Clemente A, Vives-Bauza C, Ollila HM, Hong SC, Arboleya SM, Einen MA, Faraco J, Fernandez-Vina M, Mignot E. Dual cases of type 1 narcolepsy with schizophrenia and other psychotic disorders. J Clin Sleep Med. 2014 Sep 15; 10(9):1011-8. PMID: 25142772.
    Citations: 4     Fields:    Translation:Humans
  73. Moore H, Winkelmann J, Lin L, Finn L, Peppard P, Mignot E. Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD. Sleep. 2014 Sep 01; 37(9):1535-42. PMID: 25142570.
    Citations:    
  74. De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E. Retraction of the research article: "CD4? T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy". Sci Transl Med. 2014 Jul 30; 6(247):247rt1. PMID: 25080479.
    Citations:    
  75. Goldbart A, Peppard P, Finn L, Ruoff CM, Barnet J, Young T, Mignot E. Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort. Sleep. 2014 Jun 01; 37(6):1043-51. PMID: 24882899.
    Citations:    
  76. Baumann CR, Mignot E, Lammers GJ, Overeem S, Arnulf I, Rye D, Dauvilliers Y, Honda M, Owens JA, Plazzi G, Scammell TE. Challenges in diagnosing narcolepsy without cataplexy: a consensus statement. Sleep. 2014 Jun 01; 37(6):1035-42. PMID: 24882898.
    Citations: 18     Fields:    Translation:Humans
  77. Mignot EJ. History of narcolepsy at Stanford University. Immunol Res. 2014 May; 58(2-3):315-39. PMID: 24825774.
    Citations:    
  78. Moghadam KK, Pizza F, La Morgia C, Franceschini C, Tonon C, Lodi R, Barboni P, Seri M, Ferrari S, Liguori R, Donadio V, Parchi P, Cornelio F, Inzitari D, Mignarri A, Capocchi G, Dotti MT, Winkelmann J, Lin L, Mignot E, Carelli V, Plazzi G. Narcolepsy is a common phenotype in HSAN IE and ADCA-DN. Brain. 2014 Jun; 137(Pt 6):1643-55. PMID: 24727570.
    Citations:    
  79. Warby SC, Wendt SL, Welinder P, Munk EG, Carrillo O, Sorensen HB, Jennum P, Peppard PE, Perona P, Mignot E. Sleep-spindle detection: crowdsourcing and evaluating performance of experts, non-experts and automated methods. Nat Methods. 2014 Apr; 11(4):385-92. PMID: 24562424.
    Citations:    
  80. Merikangas KR, Zhang J, Emsellem H, Swanson SA, Vgontzas A, Belouad F, Blank MM, Chen W, Einen M, He JP, Heaton L, Nakamura E, Rooholamini S, Mignot E. The structured diagnostic interview for sleep patterns and disorders: rationale and initial evaluation. Sleep Med. 2014 May; 15(5):530-5. PMID: 24780136.
    Citations: 3     Fields:    Translation:Humans
  81. Black J, Reaven NL, Funk SE, McGaughey K, Ohayon M, Guilleminault C, Ruoff C, Mignot E. The Burden of Narcolepsy Disease (BOND) study: health-care utilization and cost findings. Sleep Med. 2014 May; 15(5):522-9. PMID: 24768358.
    Citations:    
  82. Moghadam KK, Pizza F, Tonon C, Lodi R, Carelli V, Poli F, Franceschini C, Barboni P, Seri M, Ferrari S, La Morgia C, Testa C, Cornelio F, Liguori R, Winkelmann J, Lin L, Mignot E, Plazzi G. Polysomnographic and neurometabolic features may mark preclinical autosomal dominant cerebellar ataxia, deafness, and narcolepsy due to a mutation in the DNA (cytosine-5-)-methyltransferase gene, DNMT1. Sleep Med. 2014 May; 15(5):582-5. PMID: 24709307.
    Citations:    
  83. Moore HE, Andlauer O, Simon N, Mignot E. Exploring medical diagnostic performance using interactive, multi-parameter sourced receiver operating characteristic scatter plots. Comput Biol Med. 2014 Apr; 47:120-9. PMID: 24561350.
    Citations:    
  84. De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E. CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy. Sci Transl Med. 2013 Dec 18; 5(216):216ra176. PMID: 24353159.
    Citations:    
  85. Valko PO, Gavrilov YV, Yamamoto M, Reddy H, Haybaeck J, Mignot E, Baumann CR, Scammell TE. Increase of histaminergic tuberomammillary neurons in narcolepsy. Ann Neurol. 2013 Dec; 74(6):794-804. PMID: 24006291.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  86. Han F, Faraco J, Dong XS, Ollila HM, Lin L, Li J, An P, Wang S, Jiang KW, Gao ZC, Zhao L, Yan H, Liu YN, Li QH, Zhang XZ, Hu Y, Wang JY, Lu YH, Lu CJ, Zhou W, Hallmayer J, Huang YS, Strohl KP, Pollmächer T, Mignot E. Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic. PLoS Genet. 2013 Oct; 9(10):e1003880. PMID: 24204295.
    Citations: 23     Fields:    Translation:HumansCells
  87. Pizza F, Franceschini C, Peltola H, Vandi S, Finotti E, Ingravallo F, Nobili L, Bruni O, Lin L, Edwards MJ, Partinen M, Dauvilliers Y, Mignot E, Bhatia KP, Plazzi G. Clinical and polysomnographic course of childhood narcolepsy with cataplexy. Brain. 2013 Dec; 136(Pt 12):3787-95. PMID: 24142146.
    Citations:    
  88. Roth T, Dauvilliers Y, Mignot E, Montplaisir J, Paul J, Swick T, Zee P. Disrupted nighttime sleep in narcolepsy. J Clin Sleep Med. 2013 Sep 15; 9(9):955-65. PMID: 23997709.
    Citations:    
  89. Pedroso JL, Povoas Barsottini OG, Lin L, Melberg A, Oliveira AS, Mignot E. A novel de novo exon 21 DNMT1 mutation causes cerebellar ataxia, deafness, and narcolepsy in a Brazilian patient. Sleep. 2013 Aug 01; 36(8):1257-9, 1259A. PMID: 23904686.
    Citations:    
  90. Andlauer O, Moore H, Jouhier L, Drake C, Peppard PE, Han F, Hong SC, Poli F, Plazzi G, O'Hara R, Haffen E, Roth T, Young T, Mignot E. Nocturnal rapid eye movement sleep latency for identifying patients with narcolepsy/hypocretin deficiency. JAMA Neurol. 2013 Jul; 70(7):891-902. PMID: 23649748.
    Citations:    
  91. Pizza F, Vandi S, Poli F, Moghadam KK, Franceschini C, Bellucci C, Cipolli C, Ingravallo F, Natalini G, Mignot E, Plazzi G. Narcolepsy with cataplexy mimicry: the strange case of two sisters. J Clin Sleep Med. 2013 Jun 15; 9(6):611-2. PMID: 23772196.
    Citations:    
  92. Nikodemova M, Finn L, Mignot E, Salzieder N, Peppard PE. Association of sleep disordered breathing and cognitive deficit in APOE e4 carriers. Sleep. 2013 Jun 01; 36(6):873-80. PMID: 23729930.
    Citations:    
  93. Mahlios J, De la Herrán-Arita AK, Mignot E. The autoimmune basis of narcolepsy. Curr Opin Neurobiol. 2013 Oct; 23(5):767-73. PMID: 23725858.
    Citations:    
  94. Dong XS, Ma SF, Cao CW, Li J, An P, Zhao L, Liu NY, Yan H, Hu QT, Mignot E, Strohl KP, Gao ZC, Zeng C, Han F. Hypocretin (orexin) neuropeptide precursor gene, HCRT, polymorphisms in early-onset narcolepsy with cataplexy. Sleep Med. 2013 Jun; 14(6):482-7. PMID: 23643651.
    Citations:    
  95. Khor SS, Miyagawa T, Toyoda H, Yamasaki M, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Lin L, Faraco J, Rico T, Honda Y, Honda M, Mignot E, Tokunaga K. Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. PeerJ. 2013; 1:e66. PMID: 23646285.
    Citations:    
  96. Mignot E. Physiology. The perfect hypnotic? Science. 2013 Apr 05; 340(6128):36-8. PMID: 23559238.
    Citations:    
  97. Singh AK, Mahlios J, Mignot E. Genetic association, seasonal infections and autoimmune basis of narcolepsy. J Autoimmun. 2013 Jun; 43:26-31. PMID: 23497937.
    Citations:    
  98. Faraco J, Lin L, Kornum BR, Kenny EE, Trynka G, Einen M, Rico TJ, Lichtner P, Dauvilliers Y, Arnulf I, Lecendreux M, Javidi S, Geisler P, Mayer G, Pizza F, Poli F, Plazzi G, Overeem S, Lammers GJ, Kemlink D, Sonka K, Nevsimalova S, Rouleau G, Desautels A, Montplaisir J, Frauscher B, Ehrmann L, Högl B, Jennum P, Bourgin P, Peraita-Adrados R, Iranzo A, Bassetti C, Chen WM, Concannon P, Thompson SD, Damotte V, Fontaine B, Breban M, Gieger C, Klopp N, Deloukas P, Wijmenga C, Hallmayer J, Onengut-Gumuscu S, Rich SS, Winkelmann J, Mignot E. ImmunoChip study implicates antigen presentation to T cells in narcolepsy. PLoS Genet. 2013; 9(2):e1003270. PMID: 23459209.
    Citations: 46     Fields:    Translation:Humans
  99. Poli F, Pizza F, Mignot E, Ferri R, Pagotto U, Taheri S, Finotti E, Bernardi F, Pirazzoli P, Cicognani A, Balsamo A, Nobili L, Bruni O, Plazzi G. High prevalence of precocious puberty and obesity in childhood narcolepsy with cataplexy. Sleep. 2013 Feb 01; 36(2):175-81. PMID: 23372264.
    Citations:    
  100. Han F, Lin L, Li J, Dong XS, Mignot E. Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic. Ann Neurol. 2013 Apr; 73(4):560. PMID: 23225098.
    Citations:    
  101. Mignot EJ. A practical guide to the therapy of narcolepsy and hypersomnia syndromes. Neurotherapeutics. 2012 Oct; 9(4):739-52. PMID: 23065655.
    Citations:    
  102. Arnulf I, Rico TJ, Mignot E. Diagnosis, disease course, and management of patients with Kleine-Levin syndrome. Lancet Neurol. 2012 Oct; 11(10):918-28. PMID: 22995695.
    Citations:    
  103. Pelayo R, Mignot E. The treatment of sleep disorders. Neurotherapeutics. 2012 Oct; 9(4):685-6. PMID: 23070732.
    Citations:    
  104. Andlauer O, Moore H, Hong SC, Dauvilliers Y, Kanbayashi T, Nishino S, Han F, Silber MH, Rico T, Einen M, Kornum BR, Jennum P, Knudsen S, Nevsimalova S, Poli F, Plazzi G, Mignot E. Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy. Sleep. 2012 Sep 01; 35(9):1247-55F. PMID: 22942503.
    Citations:    
  105. Han F, Lin L, Li J, Dong SX, An P, Zhao L, Liu NY, Li QY, Yan H, Gao ZC, Faraco J, Strohl KP, Liu X, Miyadera H, Mignot E. HLA-DQ association and allele competition in Chinese narcolepsy. Tissue Antigens. 2012 Oct; 80(4):328-35. PMID: 22862152.
    Citations:    
  106. Knudsen S, Biering-Sørensen B, Kornum BR, Petersen ER, Ibsen JD, Gammeltoft S, Mignot E, Jennum PJ. Early IVIg treatment has no effect on post-H1N1 narcolepsy phenotype or hypocretin deficiency. Neurology. 2012 Jul 03; 79(1):102-3. PMID: 22722630.
    Citations:    
  107. Pizza F, Moghadam KK, Vandi S, Detto S, Poli F, Mignot E, Ferri R, Plazzi G. Daytime continuous polysomnography predicts MSLT results in hypersomnias of central origin. J Sleep Res. 2013 Feb; 22(1):32-40. PMID: 22716477.
    Citations:    
  108. Winkelmann J, Lin L, Schormair B, Kornum BR, Faraco J, Plazzi G, Melberg A, Cornelio F, Urban AE, Pizza F, Poli F, Grubert F, Wieland T, Graf E, Hallmayer J, Strom TM, Mignot E. Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy. Hum Mol Genet. 2012 May 15; 21(10):2205-10. PMID: 22328086.
    Citations:    
  109. Aran A, Shors I, Lin L, Mignot E, Schimmel MS. CSF levels of hypocretin-1 (orexin-A) peak during early infancy in humans. Sleep. 2012 Feb 01; 35(2):187-91. PMID: 22294808.
    Citations:    
  110. Weiner Lachmi K, Lin L, Kornum BR, Rico T, Lo B, Aran A, Mignot E. DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status. Hum Immunol. 2012 Apr; 73(4):405-10. PMID: 22326585.
    Citations:    
  111. Goel N, Banks S, Lin L, Mignot E, Dinges DF. Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss. PLoS One. 2011; 6(12):e29283. PMID: 22216231.
    Citations:    
  112. Han F, Lin L, Li J, Aran A, Dong SX, An P, Zhao L, Li QY, Yan H, Wang JS, Gao HY, Li M, Gao ZC, Strohl KP, Mignot E. TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy. Sleep Med. 2012 Mar; 13(3):269-72. PMID: 22177342.
    Citations:    
  113. Palaia V, Poli F, Pizza F, Antelmi E, Franceschini C, Moghadam KK, Provini F, Pagotto U, Montagna P, Schenck CH, Mignot E, Plazzi G. Narcolepsy with cataplexy associated with nocturnal compulsive behaviors: a case-control study. Sleep. 2011 Oct 01; 34(10):1365-71. PMID: 21966068.
    Citations:    
  114. Kornum BR, Faraco J, Mignot E. Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain. Curr Opin Neurobiol. 2011 Dec; 21(6):897-903. PMID: 21963829.
    Citations:    
  115. Aran A, Lin L, Finn LA, Weiner K, Peppard P, Young T, Mignot E. Post-streptococcal antibodies are associated with metabolic syndrome in a population-based cohort. PLoS One. 2011; 6(9):e25017. PMID: 21949836.
    Citations:    
  116. Plazzi G, Pizza F, Palaia V, Franceschini C, Poli F, Moghadam KK, Cortelli P, Nobili L, Bruni O, Dauvilliers Y, Lin L, Edwards MJ, Mignot E, Bhatia KP. Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. Brain. 2011 Dec; 134(Pt 12):3477-89. PMID: 21930661.
    Citations:    
  117. Zeitzer JM, Kodama T, Buckmaster CL, Honda Y, Lyons DM, Nishino S, Mignot E. Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey. J Sleep Res. 2012 Apr; 21(2):189-94. PMID: 21910776.
    Citations:    
  118. Han F, Lin L, Warby SC, Faraco J, Li J, Dong SX, An P, Zhao L, Wang LH, Li QY, Yan H, Gao ZC, Yuan Y, Strohl KP, Mignot E. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol. 2011 Sep; 70(3):410-7. PMID: 21866560.
    Citations:    
  119. Winkelmann J, Czamara D, Schormair B, Knauf F, Schulte EC, Trenkwalder C, Dauvilliers Y, Polo O, Högl B, Berger K, Fuhs A, Gross N, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Xiong L, Montplaisir J, Rouleau GA, Fietze I, Vávrová J, Kemlink D, Sonka K, Nevsimalova S, Lin SC, Wszolek Z, Vilariño-Güell C, Farrer MJ, Gschliesser V, Frauscher B, Falkenstetter T, Poewe W, Allen RP, Earley CJ, Ondo WG, Le WD, Spieler D, Kaffe M, Zimprich A, Kettunen J, Perola M, Silander K, Cournu-Rebeix I, Francavilla M, Fontenille C, Fontaine B, Vodicka P, Prokisch H, Lichtner P, Peppard P, Faraco J, Mignot E, Gieger C, Illig T, Wichmann HE, Müller-Myhsok B, Meitinger T. Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. PLoS Genet. 2011 Jul; 7(7):e1002171. PMID: 21779176.
    Citations:    
  120. Han F, Lin L, Li J, Aran A, Dong SX, An P, Zhao L, Li M, Li QY, Yan H, Wang JS, Gao HY, Li M, Gao ZC, Strohl KP, Mignot E. Presentations of primary hypersomnia in Chinese children. Sleep. 2011 May 01; 34(5):627-32. PMID: 21532956.
    Citations:    
  121. Vardeny O, Peppard PE, Finn LA, Faraco JH, Mignot E, Hla KM. ß2 adrenergic receptor polymorphisms and nocturnal blood pressure dipping status in the Wisconsin Sleep Cohort Study. J Am Soc Hypertens. 2011 Mar-Apr; 5(2):114-22. PMID: 21414566.
    Citations:    
  122. Zeitzer JM, Fisicaro RA, Grove ME, Mignot E, Yesavage JA, Friedman L. Faster REM sleep EEG and worse restedness in older insomniacs with HLA DQB1*0602. Psychiatry Res. 2011 May 30; 187(3):397-400. PMID: 21292329.
    Citations:    
  123. Nishino S, Mignot E. Narcolepsy and cataplexy. Handb Clin Neurol. 2011; 99:783-814. PMID: 21056228.
    Citations:    
  124. Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E. Common variants in P2RY11 are associated with narcolepsy. Nat Genet. 2011 Jan; 43(1):66-71. PMID: 21170044.
    Citations:    
  125. Tanaka S, Kodama T, Nonaka T, Toyoda H, Arai M, Fukazawa M, Honda Y, Honda M, Mignot E. Transcriptional regulation of the hypocretin/orexin gene by NR6A1. Biochem Biophys Res Commun. 2010 Dec 10; 403(2):178-83. PMID: 21056546.
    Citations:    
  126. Dauvilliers Y, Montplaisir J, Cochen V, Desautels A, Einen M, Lin L, Kawashima M, Bayard S, Monaca C, Tiberge M, Filipini D, Tripathy A, Nguyen BH, Kotagal S, Mignot E. Post-H1N1 narcolepsy-cataplexy. Sleep. 2010 Nov; 33(11):1428-30. PMID: 21102981.
    Citations:    
  127. Aran A, Einen M, Lin L, Plazzi G, Nishino S, Mignot E. Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children. Sleep. 2010 Nov; 33(11):1457-64. PMID: 21102987.
    Citations:    
  128. Goel N, Banks S, Mignot E, Dinges DF. DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness, and fatigue. Neurology. 2010 Oct 26; 75(17):1509-19. PMID: 20975052.
    Citations:    
  129. Appelbaum L, Wang G, Yokogawa T, Skariah GM, Smith SJ, Mourrain P, Mignot E. Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons. Neuron. 2010 Oct 06; 68(1):87-98. PMID: 20920793.
    Citations:    
  130. Aran A, Weiner K, Lin L, Finn LA, Greco MA, Peppard P, Young T, Ofran Y, Mignot E. Post-streptococcal auto-antibodies inhibit protein disulfide isomerase and are associated with insulin resistance. PLoS One. 2010 Sep 23; 5(9):e12875. PMID: 20886095.
    Citations:    
  131. Schwimmer H, Stauss HM, Abboud F, Nishino S, Mignot E, Zeitzer JM. Effects of sleep on the cardiovascular and thermoregulatory systems: a possible role for hypocretins. J Appl Physiol (1985). 2010 Oct; 109(4):1053-63. PMID: 20705949.
    Citations:    
  132. Kawashima M, Lin L, Tanaka S, Jennum P, Knudsen S, Nevsimalova S, Plazzi G, Mignot E. Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy. Sleep. 2010 Jul; 33(7):869-74. PMID: 20614846.
    Citations:    
  133. Plazzi G, Tonon C, Rubboli G, Poli F, Franceschini C, Pizza F, Bisulli A, Rizzo G, Mignot E, Montagna P, Lodi R. Narcolepsy with cataplexy associated with holoprosencephaly misdiagnosed as epileptic drop attacks. Mov Disord. 2010 Apr 30; 25(6):788-90. PMID: 20131387.
    Citations:    
  134. Hirst J, Mignot E, Stein MT. Episodic hypersomnia and unusual behaviors in a 14-year old adolescent. J Dev Behav Pediatr. 2010 Apr; 31(3 Suppl):S18-20. PMID: 20414066.
    Citations:    
  135. Han F, Mignot E, Wei YC, Dong SX, Li J, Lin L, An P, Wang LH, Wang JS, He MZ, Gao HY, Li M, Gao ZC, Strohl KP. Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status. Eur Respir J. 2010 Sep; 36(3):577-83. PMID: 20110394.
    Citations:    
  136. Berman JR, Skariah G, Maro GS, Mignot E, Mourrain P. Characterization of two melanin-concentrating hormone genes in zebrafish reveals evolutionary and physiological links with the mammalian MCH system. J Comp Neurol. 2009 Dec 10; 517(5):695-710. PMID: 19827161.
    Citations:    
  137. Appelbaum L, Wang GX, Maro GS, Mori R, Tovin A, Marin W, Yokogawa T, Kawakami K, Smith SJ, Gothilf Y, Mignot E, Mourrain P. Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21942-7. PMID: 19966231.
    Citations:    
  138. Vetrugno R, D'Angelo R, Moghadam KK, Vandi S, Franceschini C, Mignot E, Montagna P, Plazzi G. Behavioural and neurophysiological correlates of human cataplexy: a video-polygraphic study. Clin Neurophysiol. 2010 Feb; 121(2):153-62. PMID: 19955018.
    Citations:    
  139. Poli F, Plazzi G, Di Dalmazi G, Ribichini D, Vicennati V, Pizza F, Mignot E, Montagna P, Pasquali R, Pagotto U. Body mass index-independent metabolic alterations in narcolepsy with cataplexy. Sleep. 2009 Nov; 32(11):1491-7. PMID: 19928388.
    Citations:    
  140. Lammers GJ, Bassetti C, Billiard M, Black J, Broughton R, Dauvilliers Y, Ferini Strambi L, Garcia-Borreguero D, Goswami M, Högl B, Iranzo A, Jennum P, Khatami R, Lecendreux M, Mayer G, Mignot E, Montplaisir J, Nevsimalova S, Peraita-Adrados R, Plazzi G, Scammell T, Silber M, Sonka K, Tafti M, Thorpy M. Sodium oxybate is an effective and safe treatment for narcolepsy. Sleep Med. 2010 Jan; 11(1):105-6; author reply 106-8. PMID: 19846338.
    Citations: 4     Fields:    Translation:HumansAnimals
  141. Zeitzer JM, Buckmaster CL, Landolt HP, Lyons DM, Mignot E. Modafinil and ?-hydroxybutyrate have sleep state-specific pharmacological actions on hypocretin-1 physiology in a primate model of human sleep. Behav Pharmacol. 2009 Oct; 20(7):643-52. PMID: 19752724.
    Citations:    
  142. Mignot E, Huguenard JR. Resting our cortices by going DOWN to sleep. Neuron. 2009 Sep 24; 63(6):719-21. PMID: 19778500.
    Citations:    
  143. Eriksson KS, Mignot E. T-box 3 is expressed in the adult mouse hypothalamus and medulla. Brain Res. 2009 Dec 11; 1302:233-9. PMID: 19765559.
    Citations:    
  144. Honda M, Arai T, Fukazawa M, Honda Y, Tsuchiya K, Salehi A, Akiyama H, Mignot E. Absence of ubiquitinated inclusions in hypocretin neurons of patients with narcolepsy. Neurology. 2009 Aug 18; 73(7):511-7. PMID: 19687452.
    Citations:    
  145. Aran A, Lin L, Nevsimalova S, Plazzi G, Hong SC, Weiner K, Zeitzer J, Mignot E. Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep. 2009 Aug; 32(8):979-83. PMID: 19725248.
    Citations:    
  146. Goel N, Banks S, Mignot E, Dinges DF. PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation. PLoS One. 2009 Jun 11; 4(6):e5874. PMID: 19516903.
    Citations:    
  147. Hallmayer J, Faraco J, Lin L, Hesselson S, Winkelmann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, Hong SC, Hong SS, Honda Y, Honda M, Högl B, Longstreth WT, Montplaisir J, Kemlink D, Einen M, Chen J, Musone SL, Akana M, Miyagawa T, Duan J, Desautels A, Erhardt C, Hesla PE, Poli F, Frauscher B, Jeong JH, Lee SP, Ton TG, Kvale M, Kolesar L, Dobrovolná M, Nepom GT, Salomon D, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Young T, Peppard P, Tokunaga K, Kwok PY, Risch N, Mignot E. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet. 2009 Jun; 41(6):708-11. PMID: 19412176.
    Citations:    
  148. Nishino S, Sakurai E, Nevsimalova S, Yoshida Y, Watanabe T, Yanai K, Mignot E. Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls. Sleep. 2009 Feb; 32(2):175-80. PMID: 19238804.
    Citations:    
  149. Honda M, Eriksson KS, Zhang S, Tanaka S, Lin L, Salehi A, Hesla PE, Maehlen J, Gaus SE, Yanagisawa M, Sakurai T, Taheri S, Tsuchiya K, Honda Y, Mignot E. IGFBP3 colocalizes with and regulates hypocretin (orexin). PLoS One. 2009; 4(1):e4254. PMID: 19158946.
    Citations:    
  150. Donadio V, Plazzi G, Vandi S, Franceschini C, Karlsson T, Montagna P, Vetrugno R, Bugiardini E, Mignot E, Liguori R. Sympathetic and cardiovascular activity during cataplexy in narcolepsy. J Sleep Res. 2008 Dec; 17(4):458-63. PMID: 19021855.
    Citations:    
  151. Miyagawa T, Kawashima M, Nishida N, Ohashi J, Kimura R, Fujimoto A, Shimada M, Morishita S, Shigeta T, Lin L, Hong SC, Faraco J, Shin YK, Jeong JH, Okazaki Y, Tsuji S, Honda M, Honda Y, Mignot E, Tokunaga K. Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. Nat Genet. 2008 Nov; 40(11):1324-8. PMID: 18820697.
    Citations:    
  152. Plazzi G, Poli F, Franceschini C, Parmeggiani A, Pirazzoli P, Bernardi F, Mignot E, Cicognani A, Montagna P. Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy. J Neurol. 2008 Oct; 255(10):1549-54. PMID: 18769859.
    Citations:    
  153. Alaez C, Lin L, Flores-A H, Vazquez M, Munguia A, Mignot E, Haro R, Baker H, Gorodezky C. Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggested. BMC Med Genet. 2008 Aug 15; 9:79. PMID: 18706091.
    Citations:    
  154. Mishima K, Fujiki N, Yoshida Y, Sakurai T, Honda M, Mignot E, Nishino S. Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy. Sleep. 2008 Aug; 31(8):1119-26. PMID: 18714784.
    Citations:    
  155. Bourgin P, Zeitzer JM, Mignot E. CSF hypocretin-1 assessment in sleep and neurological disorders. Lancet Neurol. 2008 Jul; 7(7):649-62. PMID: 18565458.
    Citations:    
  156. Reiss AL, Hoeft F, Tenforde AS, Chen W, Mobbs D, Mignot EJ. Anomalous hypothalamic responses to humor in cataplexy. PLoS One. 2008 May 21; 3(5):e2225. PMID: 18493621.
    Citations: 10     Fields:    Translation:Humans
  157. Serra L, Montagna P, Mignot E, Lugaresi E, Plazzi G. Cataplexy features in childhood narcolepsy. Mov Disord. 2008 Apr 30; 23(6):858-65. PMID: 18307264.
    Citations:    
  158. Mignot E. Why we sleep: the temporal organization of recovery. PLoS Biol. 2008 Apr 29; 6(4):e106. PMID: 18447584.
    Citations:    
  159. Mignot E. Excessive daytime sleepiness: population and etiology versus nosology. Sleep Med Rev. 2008 Apr; 12(2):87-94. PMID: 18342260.
    Citations:    
  160. Arnulf I, Lin L, Gadoth N, File J, Lecendreux M, Franco P, Zeitzer J, Lo B, Faraco JH, Mignot E. Kleine-Levin syndrome: a systematic study of 108 patients. Ann Neurol. 2008 Apr; 63(4):482-93. PMID: 18438947.
    Citations:    
  161. Eriksson KS, Zhang S, Lin L, Larivière RC, Julien JP, Mignot E. The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse. BMC Neurosci. 2008 Feb 24; 9:26. PMID: 18294400.
    Citations:    
  162. Ciafaloni E, Mignot E, Sansone V, Hilbert JE, Lin L, Lin X, Liu LC, Pigeon WR, Perlis ML, Thornton CA. The hypocretin neurotransmission system in myotonic dystrophy type 1. Neurology. 2008 Jan 15; 70(3):226-30. PMID: 18195268.
    Citations:    
  163. Yokogawa T, Marin W, Faraco J, Pézeron G, Appelbaum L, Zhang J, Rosa F, Mourrain P, Mignot E. Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol. 2007 Oct 16; 5(10):e277. PMID: 17941721.
    Citations:    
  164. Szklo-Coxe M, Young T, Finn L, Mignot E. Depression: relationships to sleep paralysis and other sleep disturbances in a community sample. J Sleep Res. 2007 Sep; 16(3):297-312. PMID: 17716279.
    Citations:    
  165. Appelbaum L, Skariah G, Mourrain P, Mignot E. Comparative expression of p2x receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish. Brain Res. 2007 Oct 12; 1174:66-75. PMID: 17868657.
    Citations:    
  166. Zeitzer JM, Buckmaster CL, Lyons DM, Mignot E. Increasing length of wakefulness and modulation of hypocretin-1 in the wake-consolidated squirrel monkey. . 2007 Oct; 293(4):R1736-42. PMID: 17686881.
    Citations:    
  167. Taheri S, Austin D, Lin L, Nieto FJ, Young T, Mignot E. Correlates of serum C-reactive protein (CRP)--no association with sleep duration or sleep disordered breathing. Sleep. 2007 Aug; 30(8):991-6. PMID: 17702268.
    Citations:    
  168. Colas D, Valletta JS, Takimoto-Kimura R, Nishino S, Fujiki N, Mobley WC, Mignot E. Sleep and EEG features in genetic models of Down syndrome. Neurobiol Dis. 2008 Apr; 30(1):1-7. PMID: 18282758.
    Citations:    
  169. Zhang S, Lin L, Kaur S, Thankachan S, Blanco-Centurion C, Yanagisawa M, Mignot E, Shiromani PJ. The development of hypocretin (orexin) deficiency in hypocretin/ataxin-3 transgenic rats. Neuroscience. 2007 Aug 10; 148(1):34-43. PMID: 17618058.
    Citations: 23     Fields:    Translation:AnimalsCells
  170. Nevsimalova S, Prihodova I, Kemlink D, Lin L, Mignot E. REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy. Sleep Med. 2007 Nov; 8(7-8):784-6. PMID: 17569582.
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  171. Lindberg J, Saetre P, Nishino S, Mignot E, Jazin E. Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain. BMC Neurosci. 2007 May 23; 8:34. PMID: 17521418.
    Citations:    
  172. Schenck CH, Bassetti CL, Arnulf I, Mignot E. English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th century, with commentary. J Clin Sleep Med. 2007 Apr 15; 3(3):301-11. PMID: 17561602.
    Citations: 11     Fields:    Translation:Humans
  173. Patel SR, Larkin EK, Mignot E, Lin L, Redline S. The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertension. Sleep. 2007 Apr; 30(4):531-3. PMID: 17520798.
    Citations: 11