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Wayne C Koff, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Goudsmit J, van den Biggelaar AHJ, Koudstaal W, Hofman A, Koff WC, Schenkelberg T, Alter G, Mina MJ, Wu JW. Immune age and biological age as determinants of vaccine responsiveness among elderly populations: the Human Immunomics Initiative research program. Eur J Epidemiol. 2021 Jul; 36(7):753-762. PMID: 34117979.
    Citations:    Fields:    
  2. Yu ED, Grifoni A, Sutherland A, Voic H, Wang E, Frazier A, Jimenez-Truque N, Yoder S, Welsh S, Wooden S, Koff W, Creech B, Sette A, da Silva Antunes R. Balanced Cellular and Humoral Immune Responses Targeting Multiple Antigens in Adults Receiving a Quadrivalent Inactivated Influenza Vaccine. Vaccines (Basel). 2021 Apr 23; 9(5). PMID: 33922875.
  3. Koff WC, Berkley SF. A universal coronavirus vaccine. Science. 2021 02 19; 371(6531):759. PMID: 33602830.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Koff WC, Schenkelberg T, Williams T, Baric RS, McDermott A, Cameron CM, Cameron MJ, Friemann MB, Neumann G, Kawaoka Y, Kelvin AA, Ross TM, Schultz-Cherry S, Mastro TD, Priddy FH, Moore KA, Ostrowsky JT, Osterholm MT, Goudsmit J. Development and deployment of COVID-19 vaccines for those most vulnerable. Sci Transl Med. 2021 02 03; 13(579). PMID: 33536277.
    Citations: 7     Fields:    Translation:HumansAnimals
  5. Shannon CP, Blimkie TM, Ben-Othman R, Gladish N, Amenyogbe N, Drissler S, Edgar RD, Chan Q, Krajden M, Foster LJ, Kobor MS, Mohn WW, Brinkman RR, Le Cao KA, Scheuermann RH, Tebbutt SJ, Hancock REW, Koff WC, Kollmann TR, Sadarangani M, Lee AH. Multi-Omic Data Integration Allows Baseline Immune Signatures to Predict Hepatitis B Vaccine Response in a Small Cohort. Front Immunol. 2020; 11:578801. PMID: 33329547.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  6. Ben-Othman R, Cai B, Liu AC, Varankovich N, He D, Blimkie TM, Lee AH, Gill EE, Novotny M, Aevermann B, Drissler S, Shannon CP, McCann S, Marty K, Bjornson G, Edgar RD, Lin DTS, Gladish N, Maclsaac J, Amenyogbe N, Chan Q, Llibre A, Collin J, Landais E, Le K, Reiss SM, Koff WC, Havenar-Daughton C, Heran M, Sangha B, Walt D, Krajden M, Crotty S, Sok D, Briney B, Burton DR, Duffy D, Foster LJ, Mohn WW, Kobor MS, Tebbutt SJ, Brinkman RR, Scheuermann RH, Hancock REW, Kollmann TR, Sadarangani M. Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults. Front Immunol. 2020; 11:580373. PMID: 33250895.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  7. Koff WC. Preface. Vaccine. 2020 06 09; 38(28):4484. PMID: 32402757.
    Citations:    Fields:    
  8. Koff WC, Williams MA. Covid-19 and Immunity in Aging Populations - A New Research Agenda. N Engl J Med. 2020 Aug 27; 383(9):804-805. PMID: 32302079.
    Citations: 60     Fields:    Translation:HumansCellsPHPublic Health
  9. Tsang JS, Dobaño C, VanDamme P, Moncunill G, Marchant A, Othman RB, Sadarangani M, Koff WC, Kollmann TR. Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome? Trends Immunol. 2020 06; 41(6):457-465. PMID: 32340868.
    Citations: 16     Fields:    Translation:HumansPHPublic Health
  10. Cable J, Srikantiah P, Crowe JE, Pulendran B, Hill A, Ginsberg A, Koff W, Mathew A, Ng T, Jansen K, Glenn G, Permar S, Wilson I, Weiner DB, Weissman D, Rappuoli R. Vaccine innovations for emerging infectious diseases-a symposium report. Ann N Y Acad Sci. 2020 02; 1462(1):14-26. PMID: 31659752.
    Citations: 2     Fields:    Translation:HumansAnimalsPHPublic Health
  11. Koff WC, Schenkelberg T. The future of vaccine development. Vaccine. 2020 06 09; 38(28):4485-4486. PMID: 31443989.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  12. Wooden SL, Koff WC. The Human Vaccines Project: Towards a comprehensive understanding of the human immune response to immunization. Hum Vaccin Immunother. 2018; 14(9):2214-2216. PMID: 29847214.
    Citations: 4     Fields:    Translation:Humans
  13. Scheuermann RH, Sinkovits RS, Schenkelberg T, Koff WC. A bioinformatics roadmap for the human vaccines project. Expert Rev Vaccines. 2017 06; 16(6):535-544. PMID: 28434256.
    Citations: 2     Fields:    Translation:Humans
  14. Das S, Boliar S, Mitra N, Samal S, Bansal M, Koff WC, Chakrabarti BK. Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes. Retrovirology. 2016 Nov 21; 13(1):81. PMID: 27871328.
    Citations: 3     Fields:    Translation:HumansCells
  15. Safrit JT, Koff WC. Novel approaches in preclinical HIV vaccine research. Curr Opin HIV AIDS. 2016 11; 11(6):601-606. PMID: 27636502.
    Citations:    Fields:    Translation:Humans
  16. Deshpande S, Patil S, Kumar R, Shrivastava T, Srikrishnan AK, Murugavel KG, Koff WC, Chakrabarti BK, Bhattacharya J. Association of mutations in V3/C3 domain with enhanced sensitivity of HIV-1 clade C primary envelopes to autologous broadly neutralizing plasma antibodies. Retrovirology. 2016 06 15; 13(1):41. PMID: 27307004.
    Citations: 1     Fields:    Translation:HumansCells
  17. Koff WC, Schenkelberg T. Decoding the human immune system to transform the future of global disease prevention and control. Expert Rev Vaccines. 2016 10; 15(10):1235-6. PMID: 27010379.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  18. Kong R, Xu K, Zhou T, Acharya P, Lemmin T, Liu K, Ozorowski G, Soto C, Taft JD, Bailer RT, Cale EM, Chen L, Choi CW, Chuang GY, Doria-Rose NA, Druz A, Georgiev IS, Gorman J, Huang J, Joyce MG, Louder MK, Ma X, McKee K, O'Dell S, Pancera M, Yang Y, Blanchard SC, Mothes W, Burton DR, Koff WC, Connors M, Ward AB, Kwong PD, Mascola JR. Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody. Science. 2016 May 13; 352(6287):828-33. PMID: 27174988.
    Citations: 131     Fields:    Translation:HumansCells
  19. Koff WC. A shot at AIDS. Curr Opin Biotechnol. 2016 12; 42:147-151. PMID: 27153215.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  20. Stewart-Jones GB, Soto C, Lemmin T, Chuang GY, Druz A, Kong R, Thomas PV, Wagh K, Zhou T, Behrens AJ, Bylund T, Choi CW, Davison JR, Georgiev IS, Joyce MG, Kwon YD, Pancera M, Taft J, Yang Y, Zhang B, Shivatare SS, Shivatare VS, Lee CC, Wu CY, Bewley CA, Burton DR, Koff WC, Connors M, Crispin M, Baxa U, Korber BT, Wong CH, Mascola JR, Kwong PD. Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G. Cell. 2016 May 05; 165(4):813-26. PMID: 27114034.
    Citations: 187     Fields:    Translation:Cells
  21. Romero P, Banchereau J, Bhardwaj N, Cockett M, Disis ML, Dranoff G, Gilboa E, Hammond SA, Hershberg R, Korman AJ, Kvistborg P, Melief C, Mellman I, Palucka AK, Redchenko I, Robins H, Sallusto F, Schenkelberg T, Schoenberger S, Sosman J, Türeci Ö, Van den Eynde B, Koff W, Coukos G. The Human Vaccines Project: A roadmap for cancer vaccine development. Sci Transl Med. 2016 Apr 13; 8(334):334ps9. PMID: 27075624.
    Citations: 60     Fields:    Translation:HumansCells
  22. Safrit JT, Fast PE, Gieber L, Kuipers H, Dean HJ, Koff WC. Status of vaccine research and development of vaccines for HIV-1. Vaccine. 2016 06 03; 34(26):2921-2925. PMID: 26993335.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  23. Patil S, Kumar R, Deshpande S, Samal S, Shrivastava T, Boliar S, Bansal M, Chaudhary NK, Srikrishnan AK, Murugavel KG, Solomon S, Simek M, Koff WC, Goyal R, Chakrabarti BK, Bhattacharya J. Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C-Infected Elite Neutralizer Mediate Autologous Virus Escape through Mutations in the V1 Loop. J Virol. 2016 Jan 13; 90(7):3446-57. PMID: 26763999.
    Citations: 14     Fields:    Translation:HumansCells
  24. de Taeye SW, Ozorowski G, Torrents de la Peña A, Guttman M, Julien JP, van den Kerkhof TL, Burger JA, Pritchard LK, Pugach P, Yasmeen A, Crampton J, Hu J, Bontjer I, Torres JL, Arendt H, DeStefano J, Koff WC, Schuitemaker H, Eggink D, Berkhout B, Dean H, LaBranche C, Crotty S, Crispin M, Montefiori DC, Klasse PJ, Lee KK, Moore JP, Wilson IA, Ward AB, Sanders RW. Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes. Cell. 2015 Dec 17; 163(7):1702-15. PMID: 26687358.
    Citations: 183     Fields:    Translation:AnimalsCells
  25. Sette A, Schenkelberg TR, Koff WC. Deciphering the human antigenome. Expert Rev Vaccines. 2016; 15(2):167-71. PMID: 26629807.
    Citations: 4     Fields:    Translation:Humans
  26. Crowe JE, Koff WC. Deciphering the human immunome. Expert Rev Vaccines. 2015; 14(11):1421-5. PMID: 26485213.
    Citations: 4     Fields:    Translation:Humans
  27. Sanders RW, van Gils MJ, Derking R, Sok D, Ketas TJ, Burger JA, Ozorowski G, Cupo A, Simonich C, Goo L, Arendt H, Kim HJ, Lee JH, Pugach P, Williams M, Debnath G, Moldt B, van Breemen MJ, Isik G, Medina-Ramírez M, Back JW, Koff WC, Julien JP, Rakasz EG, Seaman MS, Guttman M, Lee KK, Klasse PJ, LaBranche C, Schief WR, Wilson IA, Overbaugh J, Burton DR, Ward AB, Montefiori DC, Dean H, Moore JP. HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers. Science. 2015 Jul 10; 349(6244):aac4223. PMID: 26089353.
    Citations: 281     Fields:    Translation:HumansAnimalsCells
  28. Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, Lingwood D, Soto C, Bailer RT, Ernandes MJ, Kong R, Longo NS, Louder MK, McKee K, O'Dell S, Schmidt SD, Tran L, Yang Z, Druz A, Luongo TS, Moquin S, Srivatsan S, Yang Y, Zhang B, Zheng A, Pancera M, Kirys T, Georgiev IS, Gindin T, Peng HP, Yang AS, Mullikin JC, Gray MD, Stamatatos L, Burton DR, Koff WC, Cohen MS, Haynes BF, Casazza JP, Connors M, Corti D, Lanzavecchia A, Sattentau QJ, Weiss RA, West AP, Bjorkman PJ, Scheid JF, Nussenzweig MC, Shapiro L, Mascola JR, Kwong PD. Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell. 2015 Jun 04; 161(6):1280-92. PMID: 26004070.
    Citations: 149     Fields:    Translation:HumansCells
  29. Schenkelberg T, Kieny MP, Bianco AE, Koff WC. Building the Human Vaccines Project: strategic management recommendations and summary report of the 15-16 July 2014 business workshop. Expert Rev Vaccines. 2015 May; 14(5):629-36. PMID: 25673514.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  30. He L, Sok D, Azadnia P, Hsueh J, Landais E, Simek M, Koff WC, Poignard P, Burton DR, Zhu J. Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding. Sci Rep. 2014 Oct 27; 4:6778. PMID: 25345460.
    Citations: 43     Fields:    Translation:HumansCells
  31. Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB, Kwong PD, Blanchard SC, Mothes W. Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions. Science. 2014 Nov 07; 346(6210):759-63. PMID: 25298114.
    Citations: 219     Fields:    Translation:HumansCells
  32. Zhou T, Zhu J, Yang Y, Gorman J, Ofek G, Srivatsan S, Druz A, Lees CR, Lu G, Soto C, Stuckey J, Burton DR, Koff WC, Connors M, Kwong PD, Kwon PD. Transplanting supersites of HIV-1 vulnerability. PLoS One. 2014; 9(7):e99881. PMID: 24992528.
    Citations: 34     Fields:    Translation:HumansCells
  33. Koff WC, Gust ID, Plotkin SA. Toward a human vaccines project. Nat Immunol. 2014 Jul; 15(7):589-92. PMID: 24940943.
    Citations: 16     Fields:    Translation:Humans
  34. Falkowska E, Le KM, Ramos A, Doores KJ, Lee JH, Blattner C, Ramirez A, Derking R, van Gils MJ, Liang CH, Mcbride R, von Bredow B, Shivatare SS, Wu CY, Chan-Hui PY, Liu Y, Feizi T, Zwick MB, Koff WC, Seaman MS, Swiderek K, Moore JP, Evans D, Paulson JC, Wong CH, Ward AB, Wilson IA, Sanders RW, Poignard P, Burton DR. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers. Immunity. 2014 May 15; 40(5):657-68. PMID: 24768347.
    Citations: 213     Fields:    Translation:HumansCells
  35. McMichael AJ, Koff WC. Vaccines that stimulate T cell immunity to HIV-1: the next step. Nat Immunol. 2014 Apr; 15(4):319-22. PMID: 24646598.
    Citations: 35     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  36. Zhou T, Zhu J, Wu X, Moquin S, Zhang B, Acharya P, Georgiev IS, Altae-Tran HR, Chuang GY, Joyce MG, Kwon YD, Longo NS, Louder MK, Luongo T, McKee K, Schramm CA, Skinner J, Yang Y, Yang Z, Zhang Z, Zheng A, Bonsignori M, Haynes BF, Scheid JF, Nussenzweig MC, Simek M, Burton DR, Koff WC, Mullikin JC, Connors M, Shapiro L, Nabel GJ, Mascola JR, Kwong PD. Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. Immunity. 2013 Aug 22; 39(2):245-58. PMID: 23911655.
    Citations: 178     Fields:    Translation:HumansCells
  37. Amin MN, McLellan JS, Huang W, Orwenyo J, Burton DR, Koff WC, Kwong PD, Wang LX. Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies. Nat Chem Biol. 2013 Aug; 9(8):521-6. PMID: 23831758.
    Citations: 58     Fields:    Translation:Cells
  38. Koff WC, Burton DR, Johnson PR, Walker BD, King CR, Nabel GJ, Ahmed R, Bhan MK, Plotkin SA. Accelerating next-generation vaccine development for global disease prevention. Science. 2013 May 31; 340(6136):1232910. PMID: 23723240.
    Citations: 113     Fields:    Translation:HumansAnimalsPHPublic Health
  39. Pancera M, Shahzad-Ul-Hussan S, Doria-Rose NA, McLellan JS, Bailer RT, Dai K, Loesgen S, Louder MK, Staupe RP, Yang Y, Zhang B, Parks R, Eudailey J, Lloyd KE, Blinn J, Alam SM, Haynes BF, Amin MN, Wang LX, Burton DR, Koff WC, Nabel GJ, Mascola JR, Bewley CA, Kwong PD. Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. Nat Struct Mol Biol. 2013 Jul; 20(7):804-13. PMID: 23708607.
    Citations: 166     Fields:    Translation:HumansCells
  40. Koff WC, Russell ND, Walport M, Feinberg MB, Shiver JW, Karim SA, Walker BD, McGlynn MG, Nweneka CV, Nabel GJ. Accelerating the development of a safe and effective HIV vaccine: HIV vaccine case study for the Decade of Vaccines. Vaccine. 2013 Apr 18; 31 Suppl 2:B204-8. PMID: 23598483.
    Citations: 10     Fields:    Translation:Humans
  41. Zhu J, Ofek G, Yang Y, Zhang B, Louder MK, Lu G, McKee K, Pancera M, Skinner J, Zhang Z, Parks R, Eudailey J, Lloyd KE, Blinn J, Alam SM, Haynes BF, Simek M, Burton DR, Koff WC, Mullikin JC, Mascola JR, Shapiro L, Kwong PD. Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6470-5. PMID: 23536288.
    Citations: 80     Fields:    Translation:HumansCells
  42. Hoffenberg S, Powell R, Carpov A, Wagner D, Wilson A, Kosakovsky Pond S, Lindsay R, Arendt H, Destefano J, Phogat S, Poignard P, Fling SP, Simek M, Labranche C, Montefiori D, Wrin T, Phung P, Burton D, Koff W, King CR, Parks CL, Caulfield MJ. Identification of an HIV-1 clade A envelope that exhibits broad antigenicity and neutralization sensitivity and elicits antibodies targeting three distinct epitopes. J Virol. 2013 May; 87(10):5372-83. PMID: 23468492.
    Citations: 31     Fields:    Translation:HumansCells
  43. Pancera M, Yang Y, Louder MK, Gorman J, Lu G, McLellan JS, Stuckey J, Zhu J, Burton DR, Koff WC, Mascola JR, Kwong PD. N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function. PLoS One. 2013; 8(2):e55701. PMID: 23431362.
    Citations: 23     Fields:    Translation:HumansCells
  44. Zhu J, O'Dell S, Ofek G, Pancera M, Wu X, Zhang B, Zhang Z, Mullikin JC, Simek M, Burton DR, Koff WC, Shapiro L, Mascola JR, Kwong PD. Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics. Front Microbiol. 2012; 3:315. PMID: 23024643.
    Citations: 42     
  45. Champiat S, Raposo RA, Maness NJ, Lehman JL, Purtell SE, Hasenkrug AM, Miller JC, Dean H, Koff WC, Hong MA, Martin JN, Deeks SG, Spotts GE, Pilcher CD, Hecht FM, Kallas EG, Garrison KE, Nixon DF. Influence of HAART on alternative reading frame immune responses over the course of HIV-1 infection. PLoS One. 2012; 7(6):e39311. PMID: 22768072.
    Citations: 11     Fields:    Translation:HumansCells
  46. Doria-Rose NA, Georgiev I, O'Dell S, Chuang GY, Staupe RP, McLellan JS, Gorman J, Pancera M, Bonsignori M, Haynes BF, Burton DR, Koff WC, Kwong PD, Mascola JR. A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies. J Virol. 2012 Aug; 86(15):8319-23. PMID: 22623764.
    Citations: 53     Fields:    Translation:HumansCells
  47. Reynolds MR, Weiler AM, Piaskowski SM, Piatak M, Robertson HT, Allison DB, Bett AJ, Casimiro DR, Shiver JW, Wilson NA, Lifson JD, Koff WC, Watkins DI. A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge. Vaccine. 2012 Jun 22; 30(30):4465-75. PMID: 22569124.
    Citations: 20     Fields:    Translation:AnimalsCells
  48. McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-ul-Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, Georgiev I, Kwon YD, Lee D, Louder MK, Moquin S, Schmidt SD, Yang ZY, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Burton DR, Koff WC, Walker LM, Phogat S, Wyatt R, Orwenyo J, Wang LX, Arthos J, Bewley CA, Mascola JR, Nabel GJ, Schief WR, Ward AB, Wilson IA, Kwong PD. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature. 2011 Nov 23; 480(7377):336-43. PMID: 22113616.
    Citations: 498     Fields:    Translation:Cells
  49. Koff WC. HIV vaccine development: challenges and opportunities towards solving the HIV vaccine-neutralizing antibody problem. Vaccine. 2012 Jun 19; 30(29):4310-5. PMID: 22100891.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  50. Walker LM, Huber M, Doores KJ, Falkowska E, Pejchal R, Julien JP, Wang SK, Ramos A, Chan-Hui PY, Moyle M, Mitcham JL, Hammond PW, Olsen OA, Phung P, Fling S, Wong CH, Phogat S, Wrin T, Simek MD, Koff WC, Wilson IA, Burton DR, Poignard P. Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature. 2011 Sep 22; 477(7365):466-70. PMID: 21849977.
    Citations: 857     Fields:    Translation:HumansCells
  51. Wu X, Zhou T, Zhu J, Zhang B, Georgiev I, Wang C, Chen X, Longo NS, Louder M, McKee K, O'Dell S, Perfetto S, Schmidt SD, Shi W, Wu L, Yang Y, Yang ZY, Yang Z, Zhang Z, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Simek M, Burton DR, Koff WC, Doria-Rose NA, Connors M, Mullikin JC, Nabel GJ, Roederer M, Shapiro L, Kwong PD, Mascola JR. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science. 2011 Sep 16; 333(6049):1593-602. PMID: 21835983.
    Citations: 498     Fields:    Translation:HumansCells
  52. Reynolds MR, Sacha JB, Weiler AM, Borchardt GJ, Glidden CE, Sheppard NC, Norante FA, Castrovinci PA, Harris JJ, Robertson HT, Friedrich TC, McDermott AB, Wilson NA, Allison DB, Koff WC, Johnson WE, Watkins DI. The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge. J Virol. 2011 Sep; 85(18):9637-40. PMID: 21734037.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  53. Excler JL, Rida W, Priddy F, Gilmour J, McDermott AB, Kamali A, Anzala O, Mutua G, Sanders EJ, Koff W, Berkley S, Fast P. AIDS vaccines and preexposure prophylaxis: is synergy possible? AIDS Res Hum Retroviruses. 2011 Jun; 27(6):669-80. PMID: 21043994.
    Citations: 18     Fields:    Translation:HumansAnimals
  54. Excler JL, Parks CL, Ackland J, Rees H, Gust ID, Koff WC. Replicating viral vectors as HIV vaccines: summary report from the IAVI-sponsored satellite symposium at the AIDS vaccine 2009 conference. Biologicals. 2010 Jul; 38(4):511-21. PMID: 20537552.
    Citations: 12     Fields:    Translation:Humans
  55. Reynolds MR, Weiler AM, Piaskowski SM, Kolar HL, Hessell AJ, Weiker M, Weisgrau KL, León EJ, Rogers WE, Makowsky R, McDermott AB, Boyle R, Wilson NA, Allison DB, Burton DR, Koff WC, Watkins DI. Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge. J Virol. 2010 Sep; 84(18):9190-9. PMID: 20592091.
    Citations: 50     Fields:    Translation:AnimalsCells
  56. Pejchal R, Walker LM, Stanfield RL, Phogat SK, Koff WC, Poignard P, Burton DR, Wilson IA. Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11483-8. PMID: 20534513.
    Citations: 125     Fields:    Translation:HumansCells
  57. Koff WC. Accelerating HIV vaccine development. Nature. 2010 Mar 11; 464(7286):161-2. PMID: 20220821.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  58. Moser JM, Sassano ER, Leistritz del C, Eatrides JM, Phogat S, Koff W, Drake DR. Optimization of a dendritic cell-based assay for the in vitro priming of naïve human CD4+ T cells. J Immunol Methods. 2010 Feb 28; 353(1-2):8-19. PMID: 19925804.
    Citations: 27     Fields:    Translation:HumansCells
  59. Hessell AJ, Rakasz EG, Tehrani DM, Huber M, Weisgrau KL, Landucci G, Forthal DN, Koff WC, Poignard P, Watkins DI, Burton DR. Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L. J Virol. 2010 Feb; 84(3):1302-13. PMID: 19906907.
    Citations: 195     Fields:    Translation:HumansCells
  60. Walker LM, Phogat SK, Chan-Hui PY, Wagner D, Phung P, Goss JL, Wrin T, Simek MD, Fling S, Mitcham JL, Lehrman JK, Priddy FH, Olsen OA, Frey SM, Hammond PW, Kaminsky S, Zamb T, Moyle M, Koff WC, Poignard P, Burton DR. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science. 2009 Oct 09; 326(5950):285-9. PMID: 19729618.
    Citations: 1046     Fields:    Translation:HumansCells
  61. Hessell AJ, Rakasz EG, Poignard P, Hangartner L, Landucci G, Forthal DN, Koff WC, Watkins DI, Burton DR. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathog. 2009 May; 5(5):e1000433. PMID: 19436712.
    Citations: 306     Fields:    Translation:HumansAnimalsCells
  62. Simek MD, Rida W, Priddy FH, Pung P, Carrow E, Laufer DS, Lehrman JK, Boaz M, Tarragona-Fiol T, Miiro G, Birungi J, Pozniak A, McPhee DA, Manigart O, Karita E, Inwoley A, Jaoko W, Dehovitz J, Bekker LG, Pitisuttithum P, Paris R, Walker LM, Poignard P, Wrin T, Fast PE, Burton DR, Koff WC. Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm. J Virol. 2009 Jul; 83(14):7337-48. PMID: 19439467.
    Citations: 314     Fields:    Translation:HumansCells
  63. Reynolds MR, Weiler AM, Weisgrau KL, Piaskowski SM, Furlott JR, Weinfurter JT, Kaizu M, Soma T, León EJ, MacNair C, Leaman DP, Zwick MB, Gostick E, Musani SK, Price DA, Friedrich TC, Rakasz EG, Wilson NA, McDermott AB, Boyle R, Allison DB, Burton DR, Koff WC, Watkins DI. Macaques vaccinated with live-attenuated SIV control replication of heterologous virus. J Exp Med. 2008 Oct 27; 205(11):2537-50. PMID: 18838548.
    Citations: 96     Fields:    Translation:AnimalsCells
  64. Koff WC, Parks CL, Berkhout B, Ackland J, Noble S, Gust ID. Replicating viral vectors as HIV vaccines Summary Report from IAVI Sponsored Satellite Symposium, International AIDS Society Conference, July 22, 2007. Biologicals. 2008 Sep; 36(5):277-86. PMID: 18555698.
    Citations: 7     Fields:    Translation:HumansAnimals
  65. Watkins DI, Burton DR, Kallas EG, Moore JP, Koff WC. Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans. Nat Med. 2008 Jun; 14(6):617-21. PMID: 18535579.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  66. Excler JL, Rida W, Priddy F, Fast P, Koff W. A strategy for accelerating the development of preventive AIDS vaccines. AIDS. 2007 Nov 12; 21(17):2259-63. PMID: 18090273.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  67. Berkley SF, Koff WC. Scientific and policy challenges to development of an AIDS vaccine. Lancet. 2007 Jul 07; 370(9581):94-101. PMID: 17617277.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  68. Phogat SK, Kaminsky SM, Koff WC. HIV-1 rational vaccine design: molecular details of b12-gp120 complex structure. Expert Rev Vaccines. 2007 Jun; 6(3):319-21. PMID: 17542747.
    Citations: 3     Fields:    
  69. Koff WC, Johnson PR, Watkins DI, Burton DR, Lifson JD, Hasenkrug KJ, McDermott AB, Schultz A, Zamb TJ, Boyle R, Desrosiers RC. HIV vaccine design: insights from live attenuated SIV vaccines. Nat Immunol. 2006 Jan; 7(1):19-23. PMID: 16357854.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  70. Burton DR, Desrosiers RC, Johnson PR, Koff WC. An AIDS vaccine: no time to give up. Lancet. 2004 Nov 27-Dec 3; 364(9449):1938. PMID: 15567008.
    Citations: 2     Fields:    Translation:HumansAnimals
  71. Emini EA, Koff WC. AIDS/HIV. Developing an AIDS vaccine: need, uncertainty, hope. Science. 2004 Jun 25; 304(5679):1913-4. PMID: 15218131.
    Citations: 17     Fields:    Translation:HumansCells
  72. Finstad CL, Wang CY, Kowalski J, Zhang M, Li ML, Li XM, Xia WG, Bosland MC, Murthy KK, Walfield AM, Koff WC, Zamb TJ. Synthetic luteinizing hormone releasing hormone (LHRH) vaccine for effective androgen deprivation and its application to prostate cancer immunotherapy. Vaccine. 2004 Mar 12; 22(9-10):1300-13. PMID: 15003660.
    Citations: 4     Fields:    Translation:HumansAnimals
  73. Burton DR, Desrosiers RC, Doms RW, Koff WC, Kwong PD, Moore JP, Nabel GJ, Sodroski J, Wilson IA, Wyatt RT. HIV vaccine design and the neutralizing antibody problem. Nat Immunol. 2004 Mar; 5(3):233-6. PMID: 14985706.
    Citations: 371     Fields:    Translation:HumansCells
  74. Lambert JS, Keefer M, Mulligan MJ, Schwartz D, Mestecky J, Weinhold K, Smith C, Hsieh R, Moldoveanu Z, Fast P, Forrest B, Koff W. A Phase I safety and immunogenicity trial of UBI microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects. Vaccine. 2001 Apr 30; 19(23-24):3033-42. PMID: 11311997.
    Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
  75. Seth A, Yasutomi Y, Jacoby H, Callery JC, Kaminsky SM, Koff WC, Nixon DF, Letvin NL. Evaluation of a lipopeptide immunogen as a therapeutic in HIV type 1-seropositive individuals. AIDS Res Hum Retroviruses. 2000 Mar 01; 16(4):337-43. PMID: 10716371.
    Citations: 5     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  76. Wang CY, Sawyer LS, Murthy KK, Fang X, Walfield AM, Ye J, Wang JJ, Chen PD, Li ML, Salas MT, Shen M, Gauduin MC, Boyle RW, Koup RA, Montefiori DC, Mascola JR, Koff WC, Hanson CV. Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10367-72. PMID: 10468614.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  77. Singh M, Li XM, Wang H, McGee JP, Zamb T, Koff W, Wang CY, O'Hagan DT. Controlled release microparticles as a single dose diphtheria toxoid vaccine: immunogenicity in small animal models. Vaccine. 1998 Feb; 16(4):346-52. PMID: 9607054.
    Citations: 4     Fields:    Translation:AnimalsCells
  78. Singh M, Hioe C, Qiu H, Li XM, Wang CY, Koff W, Zamb T, Nixon DF. CTL induction using synthetic peptides delivered in emulsions--critical role of the formulation procedure. Vaccine. 1997 Nov; 15(16):1773-8. PMID: 9364682.
    Citations:    Fields:    Translation:AnimalsCells
  79. Ishii N, Fukushima J, Kaneko T, Okada E, Tani K, Tanaka SI, Hamajima K, Xin KQ, Kawamoto S, Koff W, Nishioka K, Yasuda T, Okuda K. Cationic liposomes are a strong adjuvant for a DNA vaccine of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses. 1997 Nov 01; 13(16):1421-8. PMID: 9359662.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  80. Singh M, McGee JP, Li XM, Koff W, Zamb T, Wang CY, O'Hagan DT. Biodegradable microparticles with an entrapped branched octameric peptide as a controlled-release HIV-1 vaccine. J Pharm Sci. 1997 Nov; 86(11):1229-33. PMID: 9383731.
    Citations: 3     Fields:    Translation:AnimalsPHPublic Health
  81. Okuda K, Xin KO, Tsuji T, Bukawa H, Tanaka S, Koff WC, Tani K, Okuda K, Honma K, Kawamoto S, Hamajima K, Fukushima J. DNA vaccination followed by macromolecular multicomponent peptide vaccination against HIV-1 induces strong antigen-specific immunity. Vaccine. 1997 Jul; 15(10):1049-56. PMID: 9269046.
    Citations: 2     Fields:    Translation:AnimalsCells
  82. Li D, Forrest BD, Li Z, Xue P, Hanson CV, Duan S, Cheng H, Li M, Wang CY, Koff WC. International clinical trials of HIV vaccines: II. phase I trial of an HIV-1 synthetic peptide vaccine evaluating an accelerated immunization schedule in Yunnan, China. Asian Pac J Allergy Immunol. 1997 Jun; 15(2):105-13. PMID: 9346275.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  83. Singh M, Li XM, Wang H, McGee JP, Zamb T, Koff W, Wang CY, O'Hagan DT. Immunogenicity and protection in small-animal models with controlled-release tetanus toxoid microparticles as a single-dose vaccine. Infect Immun. 1997 May; 65(5):1716-21. PMID: 9125552.
    Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
  84. Tsuji T, Hamajima K, Fukushima J, Xin KQ, Ishii N, Aoki I, Ishigatsubo Y, Tani K, Kawamoto S, Nitta Y, Miyazaki J, Koff WC, Okubo T, Okuda K. Enhancement of cell-mediated immunity against HIV-1 induced by coinnoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12. J Immunol. 1997 Apr 15; 158(8):4008-13. PMID: 9103472.
    Citations: 24     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  85. Singh M, Li XM, McGee JP, Zamb T, Koff W, Wang CY, O'Hagan DT. Controlled release microparticles as a single dose hepatitis B vaccine: evaluation of immunogenicity in mice. Vaccine. 1997 Apr; 15(5):475-81. PMID: 9160514.
    Citations: 8     Fields:    Translation:AnimalsPHPublic Health
  86. Phanuphak P, Teeratakulpixarn S, Sarangbin S, Nookhai S, Ubolyam S, Sirivichayakul S, Leesavan A, Forrest BD, Hanson CV, Li M, Wang CY, Koff WC. International clinical trials of HIV vaccines: I. Phase I trial of an HIV-1 synthetic peptide vaccine in Bangkok, Thailand. Asian Pac J Allergy Immunol. 1997 Mar; 15(1):41-8. PMID: 9251847.
    Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
  87. Nixon DF, Hioe C, Chen PD, Bian Z, Kuebler P, Li ML, Qiu H, Li XM, Singh M, Richardson J, McGee P, Zamb T, Koff W, Wang CY, O'Hagan D. Synthetic peptides entrapped in microparticles can elicit cytotoxic T cell activity. Vaccine. 1996 Nov; 14(16):1523-30. PMID: 9014294.
    Citations: 20     Fields:    Translation:AnimalsCells
  88. Koff WC, Schultz AM. Progress and challenges toward an AIDS vaccine: Brother, can you spare a paradigm? J Clin Immunol. 1996 May; 16(3):127-33. PMID: 8734355.
    Citations: 1     Fields:    Translation:HumansAnimalsPHPublic Health
  89. Hioe CE, Qiu H, Chend PD, Bian Z, Li ML, Li J, Singh M, Kuebler P, McGee P, O'Hagan D, Zamb T, Koff W, Allsopp C, Wang CY, Nixon DF. Comparison of adjuvant formulations for cytotoxic T cell induction using synthetic peptides. Vaccine. 1996 Apr; 14(5):412-8. PMID: 8735553.
    Citations: 3     Fields:    Translation:AnimalsCells
  90. Gorse GJ, Keefer MC, Belshe RB, Matthews TJ, Forrest BD, Hsieh RH, Koff WC, Hanson CV, Dolin R, Weinhold KJ, Frey SE, Ketter N, Fast PE. A dose-ranging study of a prototype synthetic HIV-1MN V3 branched peptide vaccine. The National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group. J Infect Dis. 1996 Feb; 173(2):330-9. PMID: 8568293.
    Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
  91. Koff WC. The next steps toward a global AIDS vaccine. Science. 1994 Nov 25; 266(5189):1335-7. PMID: 7973724.
    Citations: 3     Fields:    Translation:Humans
  92. Koff WC, Glass MJ. Future directions in HIV vaccine development. AIDS Res Hum Retroviruses. 1992 Aug; 8(8):1313-5. PMID: 1466948.
    Citations: 1     Fields:    Translation:Humans
  93. Petricciani JC, Koff WC, Ada GL. Efficacy trials for HIV/AIDS vaccines. AIDS Res Hum Retroviruses. 1992 Aug; 8(8):1527-9. PMID: 1466997.
    Citations:    Fields:    Translation:HumansCells
  94. Ada G, Koff W, Petricciani J. The next steps in HIV vaccine development. AIDS Res Hum Retroviruses. 1992 Aug; 8(8):1317-9. PMID: 1466949.
    Citations:    Fields:    Translation:HumansAnimals
  95. Haubrich RH, Takeda A, Koff W, Smith G, Ennis FA. Studies of antibody-dependent enhancement of human immunodeficiency virus (HIV) type 1 infection mediated by Fc receptors using sera from recipients of a recombinant gp160 experimental HIV-1 vaccine. J Infect Dis. 1992 Mar; 165(3):545-8. PMID: 1538159.
    Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
  96. Karzon DT, Bolognesi DP, Koff WC. Development of a vaccine for the prevention of AIDS, a critical appraisal. Vaccine. 1992; 10(14):1039-52. PMID: 1281948.
    Citations: 4     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  97. Koff WC. The prospects for AIDS vaccines. Hosp Pract (Off Ed). 1991 Apr 15; 26(4):99-106. PMID: 2010483.
    Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
  98. Koff WC. HIV vaccine development: current status and future challenges. Biotechnol Ther. 1991; 2(1-2):195-203. PMID: 1845121.
    Citations:    Fields:    Translation:HumansAnimalsCells
  99. Schultz AM, Koff WC. Prospects for an AIDS vaccine. Semin Immunol. 1990 Sep; 2(5):351-9. PMID: 2134018.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  100. Glass MW, Schultz AM, Mathieson BJ, Lawrence D, Wescott S, Koff WC. Second annual meeting of the National Cooperative Vaccine Development Groups for AIDS. 15-18 October 1989; Fort Lauderdale, Florida. Vaccine. 1990 Aug; 8(4):413-4. PMID: 2396478.
    Citations:    Fields:    Translation:HumansAnimals
  101. Koff WC, Schultz AM. AIDS vaccines 1990: a brief update. AIDS. 1990; 4 Suppl 1:S179-84. PMID: 2152563.
    Citations:    Fields:    Translation:Humans
  102. Porter JP, Glass MJ, Koff WC. Ethical considerations in AIDS vaccine testing. IRB. 1989 May-Jun; 11(3):1-4. PMID: 11650206.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  103. Muul LM, Glass MJ, Wescott SL, Burkhardt AL, Koff WC, Strober WG. The role of mucosal immunity in development of an acquired immunodeficiency syndrome (AIDS) vaccine: workshop summary. Reg Immunol. 1989 May-Jun; 2(3):188-92. PMID: 2701579.
    Citations:    Fields:    Translation:HumansAnimalsCells
  104. Koff WC, Fauci AS. Human trials of AIDS vaccines: current status and future directions. AIDS. 1989; 3 Suppl 1:S125-9. PMID: 2558684.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  105. Koff WC, Hoth DF. Development and testing of AIDS vaccines. Science. 1988 Jul 22; 241(4864):426-32. PMID: 3293212.
    Citations: 17     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  106. Koff WC, Elm JL, Halstead SB. Suppression of dengue virus replication in vitro by rimantadine hydrochloride. Am J Trop Med Hyg. 1981 Jan; 30(1):184-9. PMID: 7212165.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  107. Koff WC, Elm JL, Halstead SB. Inhibition of dengue virus replication by amantadine hydrochloride. Antimicrob Agents Chemother. 1980 Jul; 18(1):125-9. PMID: 7416739.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  108. Koff WC, Knight V. Inhibition of influenza virus uncoating by rimantadine hydrochloride. J Virol. 1979 Jul; 31(1):261-3. PMID: 501798.
    Citations: 22     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.