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Simona Sara Dalin, Ph.D.

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Department
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Biography
Massachusetts Institute of Technology, Cambridge, MAPhD02/2020Biology
Brandeis University, Waltham, MABS05/2011Biology and Mathematics

Overview
Chemotherapy resistance is a major obstacle to curing cancer patients. I use computational and experimental tools to better understand chemotherapy resistance, with the ultimate goal of improving treatments for patients. I am a postdoc with Rameen Beroukhim and Gaddy Getz at Dana Farber and the Broad Institute. My current work focuses on the contribution of genomic structural variation to chemotherapy resistance.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dalin S, Grauman-Boss B, Lauffenburger DA, Hemann MT. Collateral responses to classical cytotoxic chemotherapies are heterogeneous and sensitivities are sparse. Sci Rep. 2022 03 31; 12(1):5453. PMID: 35361803; PMCID: PMC8971507.
    Citations:    Fields:    Translation:Humans
  2. Mueller HS, Fowler CE, Dalin S, Moiso E, Udomlumleart T, Garg S, Hemann MT, Lees JA. Acquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel. Proc Natl Acad Sci U S A. 2021 08 24; 118(34). PMID: 34408017; PMCID: PMC8403834.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Dalin S, Sullivan MR, Lau AN, Grauman-Boss B, Mueller HS, Kreidl E, Fenoglio S, Luengo A, Lees JA, Vander Heiden MG, Lauffenburger DA, Hemann MT. Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance. Cancer Res. 2019 11 15; 79(22):5723-5733. PMID: 31484670.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  4. Granit RZ, Masury H, Condiotti R, Fixler Y, Gabai Y, Glikman T, Dalin S, Winter E, Nevo Y, Carmon E, Sella T, Sonnenblick A, Peretz T, Lehmann U, Paz K, Piccioni F, Regev A, Root DE, Ben-Porath I. Regulation of Cellular Heterogeneity and Rates of Symmetric and Asymmetric Divisions in Triple-Negative Breast Cancer. Cell Rep. 2018 09 18; 24(12):3237-3250. PMID: 30232005.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  5. Pirhaji L, Milani P, Dalin S, Wassie BT, Dunn DE, Fenster RJ, Avila-Pacheco J, Greengard P, Clish CB, Heiman M, Lo DC, Fraenkel E. Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements. Nat Commun. 2017 09 20; 8(1):623. PMID: 28931805.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  6. Soltis AR, Motola S, Vernia S, Ng CW, Kennedy NJ, Dalin S, Matthews BJ, Davis RJ, Fraenkel E. Hyper- and hypo- nutrition studies of the hepatic transcriptome and epigenome suggest that PPARa regulates anaerobic glycolysis. Sci Rep. 2017 03 14; 7(1):174. PMID: 28282965.
    Citations: 9     Fields:    Translation:AnimalsCells
  7. Sun D, Dalin S, Hemann MT, Lauffenburger DA, Zhao B. Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations. Sci Rep. 2016 11 07; 6:36198. PMID: 27819268; PMCID: PMC5098152.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. Tuncbag N, Milani P, Pokorny JL, Johnson H, Sio TT, Dalin S, Iyekegbe DO, White FM, Sarkaria JN, Fraenkel E. Network Modeling Identifies Patient-specific Pathways in Glioblastoma. Sci Rep. 2016 06 29; 6:28668. PMID: 27354287.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  9. Wilson JL, Dalin S, Gosline S, Hemann M, Fraenkel E, Lauffenburger DA. Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia. Integr Biol (Camb). 2016 07 11; 8(7):761-74. PMID: 27315426.
    Citations: 1     Fields:    Translation:HumansCells
  10. Gosline SJ, Gurtan AM, JnBaptiste CK, Bosson A, Milani P, Dalin S, Matthews BJ, Yap YS, Sharp PA, Fraenkel E. Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements. Cell Rep. 2016 Jan 12; 14(2):310-9. PMID: 26748710.
    Citations: 46     Fields:    Translation:HumansCells
  11. Ng CW, Yildirim F, Yap YS, Dalin S, Matthews BJ, Velez PJ, Labadorf A, Housman DE, Fraenkel E. Extensive changes in DNA methylation are associated with expression of mutant huntingtin. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2354-9. PMID: 23341638.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.