Harvard Catalyst Profiles

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Gregory Michael Findlay, M.D.,Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Segarra-Fas A, Espejo-Serrano C, Bustos F, Zhou H, Wang F, Toth R, Macartney T, Bach I, Nardocci G, Findlay GM. An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations. Sci Signal. 2022 07 12; 15(742):eabm5995. PMID: 35857630; PMCID: PMC7613676.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Bustos F, Mathur S, Espejo-Serrano C, Toth R, Hastie CJ, Virdee S, Findlay GM. Activity-based probe profiling of RNF12 E3 ubiquitin ligase function in Tonne-Kalscheuer syndrome. Life Sci Alliance. 2022 11; 5(11). PMID: 35764390; PMCID: PMC9240097.
    Citations:    Fields:    Translation:HumansCells
  3. Bustos F, Findlay GM. Therapeutic validation and targeting of signalling networks that are dysregulated in intellectual disability. FEBS J. 2022 Feb 24. PMID: 35212144.
    Citations:    Fields:    
  4. Cornejo F, Cortés BI, Findlay GM, Cancino GI. LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain. Front Cell Dev Biol. 2021; 9:659951. PMID: 34966732.
  5. Brown HA, Williams CAC, Zhou H, Rios-Szwed D, Fernandez-Alonso R, Mansoor S, McMulkin L, Toth R, Gourlay R, Peltier J, Dieguez-Martinez N, Trost M, Lizcano JM, Stavridis MP, Findlay GM. An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells. Biochem J. 2021 12 10; 478(23):4119-4136. PMID: 34780645.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Findlay GM. Linking genome variants to disease: scalable approaches to test the functional impact of human mutations. Hum Mol Genet. 2021 10 01; 30(R2):R187-R197. PMID: 34338757; PMCID: PMC8490018.
    Citations: 2     Fields:    Translation:Humans
  7. Bustos F, Espejo-Serrano C, Segarra-Fas A, Toth R, Eaton AJ, Kernohan KD, Wilson MJ, Riley LG, Findlay GM. A novel RLIM/RNF12 variant disrupts protein stability and function to cause severe Tonne-Kalscheuer syndrome. Sci Rep. 2021 05 05; 11(1):9560. PMID: 33953269; PMCID: PMC8100121.
    Citations: 2     Fields:    Translation:HumansCells
  8. Mullin NP, Varghese J, Colby D, Richardson JM, Findlay GM, Chambers I. Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal. FEBS Lett. 2021 01; 595(1):14-25. PMID: 33107035; PMCID: PMC7839479.
    Citations:    Fields:    Translation:AnimalsCells
  9. Bustos F, Segarra-Fas A, Nardocci G, Cassidy A, Antico O, Davidson L, Brandenburg L, Macartney TJ, Toth R, Hastie CJ, Moran J, Gourlay R, Varghese J, Soares RF, Montecino M, Findlay GM. Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling. Dev Cell. 2020 12 07; 55(5):629-647.e7. PMID: 33080171; PMCID: PMC7725506.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  10. Fernandez-Alonso R, Bustos F, Budzyk M, Kumar P, Helbig AO, Hukelmann J, Lamond AI, Lanner F, Zhou H, Petsalaki E, Findlay GM. Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation. Nat Commun. 2020 03 13; 11(1):1357. PMID: 32170114.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  11. Alexander J, Findlay GM, Kircher M, Shendure J. Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement. BMC Biol. 2019 11 18; 17(1):90. PMID: 31739790; PMCID: PMC6862751.
    Citations: 4     Fields:    Translation:AnimalsCells
  12. Heap RE, Segarra-Fas A, Blain AP, Findlay GM, Trost M. Profiling embryonic stem cell differentiation by MALDI TOF mass spectrometry: development of a reproducible and robust sample preparation workflow. Analyst. 2019 Oct 22; 144(21):6371-6381. PMID: 31566633.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Shendure J, Findlay GM, Snyder MW. Genomic Medicine-Progress, Pitfalls, and Promise. Cell. 2019 03 21; 177(1):45-57. PMID: 30901547; PMCID: PMC6531313.
    Citations: 38     Fields:    Translation:Humans
  14. Findlay GM, Daza RM, Martin B, Zhang MD, Leith AP, Gasperini M, Janizek JD, Huang X, Starita LM, Shendure J. Accurate classification of BRCA1 variants with saturation genome editing. Nature. 2018 10; 562(7726):217-222. PMID: 30209399.
    Citations: 228     Fields:    Translation:HumansCells
  15. Bustos F, Segarra-Fas A, Chaugule VK, Brandenburg L, Branigan E, Toth R, Macartney T, Knebel A, Hay RT, Walden H, Findlay GM. RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation. Cell Rep. 2018 05 08; 23(6):1599-1611. PMID: 29742418.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  16. Gasperini M, Findlay GM, McKenna A, Milbank JH, Lee C, Zhang MD, Cusanovich DA, Shendure J. CRISPR/Cas9-Mediated Scanning for Regulatory Elements Required for HPRT1 Expression via Thousands of Large, Programmed Genomic Deletions. Am J Hum Genet. 2017 Aug 03; 101(2):192-205. PMID: 28712454.
    Citations: 63     Fields:    Translation:HumansCells
  17. Fernandez-Alonso R, Davidson L, Hukelmann J, Zengerle M, Prescott AR, Lamond A, Ciulli A, Sapkota GP, Findlay GM. Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification. EMBO Rep. 2017 07; 18(7):1108-1122. PMID: 28588073; PMCID: PMC5494510.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  18. Williams CAC, Gray NS, Findlay GM. A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening. J Vis Exp. 2017 05 12; (123). PMID: 28570543; PMCID: PMC5607952.
    Citations: 1     Fields:    Translation:AnimalsCells
  19. Fernandez-Alonso R, Bustos F, Williams CAC, Findlay GM. Protein Kinases in Pluripotency-Beyond the Usual Suspects. J Mol Biol. 2017 05 19; 429(10):1504-1520. PMID: 28456524.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  20. Findlay GM, David L, Beyer TA. Molecular Mechanisms of Stem Cell Pluripotency and Cell Fate Specification. J Mol Biol. 2017 05 19; 429(10):1439-1440. PMID: 28302388.
    Citations:    Fields:    Translation:HumansAnimalsCells
  21. Aguet F, Upadhyayula S, Gaudin R, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, Megason S, Betzig E, Kirchhausen T. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Mol Biol Cell. 2016 11 07; 27(22):3418-3435. PMID: 27535432; PMCID: PMC5221578.
    Citations: 40     Fields:    Translation:AnimalsCells
  22. Williams CA, Fernandez-Alonso R, Wang J, Toth R, Gray NS, Findlay GM. Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity. Cell Rep. 2016 08 16; 16(7):1820-8. PMID: 27498864; PMCID: PMC4987282.
    Citations: 21     Fields:    Translation:AnimalsCells
  23. McKenna A, Findlay GM, Gagnon JA, Horwitz MS, Schier AF, Shendure J. Whole-organism lineage tracing by combinatorial and cumulative genome editing. Science. 2016 Jul 29; 353(6298):aaf7907. PMID: 27229144.
    Citations: 234     Fields:    Translation:AnimalsCells
  24. Birnbaum RY, Patwardhan RP, Kim MJ, Findlay GM, Martin B, Zhao J, Bell RJ, Smith RP, Ku AA, Shendure J, Ahituv N. Systematic dissection of coding exons at single nucleotide resolution supports an additional role in cell-specific transcriptional regulation. PLoS Genet. 2014 Oct; 10(10):e1004592. PMID: 25340400.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  25. Kumar A, Dougherty M, Findlay GM, Geisheker M, Klein J, Lazar J, Machkovech H, Resnick J, Resnick R, Salter AI, Talebi-Liasi F, Arakawa C, Baudin J, Bogaard A, Salesky R, Zhou Q, Smith K, Clark JI, Shendure J, Horwitz MS. Genome sequencing of idiopathic pulmonary fibrosis in conjunction with a medical school human anatomy course. PLoS One. 2014; 9(9):e106744. PMID: 25192356; PMCID: PMC4156421.
    Citations: 4     Fields:    Translation:Humans
  26. Findlay GM, Boyle EA, Hause RJ, Klein JC, Shendure J. Saturation editing of genomic regions by multiplex homology-directed repair. Nature. 2014 Sep 04; 513(7516):120-3. PMID: 25141179.
    Citations: 152     Fields:    Translation:HumansCells
  27. Yasui N, Findlay GM, Gish GD, Hsiung MS, Huang J, Tucholska M, Taylor L, Smith L, Boldridge WC, Koide A, Pawson T, Koide S. Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation. Mol Cell. 2014 Jun 19; 54(6):1034-1041. PMID: 24910098; PMCID: PMC4090938.
    Citations: 14     Fields:    Translation:AnimalsCells
  28. Saliba AE, Vonkova I, Ceschia S, Findlay GM, Maeda K, Tischer C, Deghou S, van Noort V, Bork P, Pawson T, Ellenberg J, Gavin AC. A quantitative liposome microarray to systematically characterize protein-lipid interactions. Nat Methods. 2014 Jan; 11(1):47-50. PMID: 24270602.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  29. Sharma S, Quintana A, Findlay GM, Mettlen M, Baust B, Jain M, Nilsson R, Rao A, Hogan PG. An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry. Nature. 2013 Jul 11; 499(7457):238-42. PMID: 23792561.
    Citations: 114     Fields:    Translation:HumansCells
  30. Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T. Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell. 2013 Feb 28; 152(5):1008-20. PMID: 23452850.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  31. Sharma S, Findlay GM, Bandukwala HS, Oberdoerffer S, Baust B, Li Z, Schmidt V, Hogan PG, Sacks DB, Rao A. Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11381-6. PMID: 21709260.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  32. Yan L, Mieulet V, Burgess D, Findlay GM, Sully K, Procter J, Goris J, Janssens V, Morrice NA, Lamb RF. PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR. Mol Cell. 2010 Mar 12; 37(5):633-42. PMID: 20227368.
    Citations: 63     Fields:    Translation:HumansCells
  33. Findlay GM, Pawson T. How is SOS activated? Let us count the ways. Nat Struct Mol Biol. 2008 Jun; 15(6):538-40. PMID: 18523461.
    Citations: 9     Fields:    Translation:Cells
  34. Findlay GM, Yan L, Procter J, Mieulet V, Lamb RF. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem J. 2007 Apr 01; 403(1):13-20. PMID: 17253963; PMCID: PMC1828895.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  35. Yan L, Findlay GM, Jones R, Procter J, Cao Y, Lamb RF. Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase. J Biol Chem. 2006 Jul 21; 281(29):19793-7. PMID: 16728407.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  36. Findlay GM, Harrington LS, Lamb RF. TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation? Curr Opin Genet Dev. 2005 Feb; 15(1):69-76. PMID: 15661536.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  37. Harrington LS, Findlay GM, Lamb RF. Restraining PI3K: mTOR signalling goes back to the membrane. Trends Biochem Sci. 2005 Jan; 30(1):35-42. PMID: 15653324.
    Citations: 152     Fields:    Translation:HumansAnimalsCells
  38. Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol. 2004 Jul 19; 166(2):213-23. PMID: 15249583; PMCID: PMC2172316.
    Citations: 478     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.