Associate Professor of Medicine
Brigham and Women's Hospital
FAS - Harvard
Northwest Lab Building
52 Oxford Street
Cambridge MA 02138
|Sun Yat-sen University , Guangzhou, PRC||BS||07/1995||Material Science, Physics|
|University of Rhode Island, Kingston, RI, USA||MS||05/1999||Quantum Physics|
|Boston University, Boston, MA, USA||PhD||02/2005||Statistical Physics, Nonlinear Dynamics)|
|Beth Israel Deaconess Medical Center, Boston, MA, USA||Postdoctoral||11/2007||Gerontology, Cardiovascular Physiology|
|Brigham & Women's Hospital, Boston, MA, USA||Postdoctoral||11/2007||Circadian Physiology|
Travel Award for Annual Meeting
Travel Award for Annual Meeting
Research Merit Trainee Travel Award
Travel Grant for Workshop "Short-term Cardiovascular-Respiratory Control Mechanisms"
Honorable Mention Abstract award
Chair's Research Award (Department of Medicine)
The Thousand Plan for Young Scholars (Selected but withdrawn)
Innovation Discovery Award
I obtained my doctoral training in statistical physics with a specific focus on nonlinear dynamic analysis and fractal physiology. During the first 5 years of my postdoctoral training, I have essentially involved in human experimental studies in two laboratories: Medical Chronobiology Program under the supervision of Dr. Steven Shea and Dr. Frank Scheer in the Division of Sleep and Circadian Disorders at BWH (sleep/circadian physiology); and SAFE (Syncope and Falls in the Elderly) Laboratory under the supervision of Dr. Vera Novak in the Division of Gerontology at Beth Israel Deaconess Medical Center (BIDMC) (for aging research). Between 2009-2011, I continued my advanced training in sleep/circadian physiology at BWH while learning about animal models involving neural lesions and gene knockouts in Dr. Clifford Saper’s lab in the Department of Neurology at BIDMC and in system biology under the guidance of Prof. Walter Fontana in the Department of System Biology at Harvard University.
With my multidisciplinary training, I have been promoting the application of the concepts/methods derived from statistical physics and nonlinear dynamics in medicine during the last 16 years. To foster such translational research in sleep medicine, I established Medical Biodynamics Program (MBP) in the Division of Sleep Medicine at HMS (https://sleep.hms.harvard.edu/research/labs-divisions/medical-biodynamics-program-mbp). My research over the last decade years has been continuously funded by the NIH (K99 HL102241, R00 HL102241, R01AG048108, RF1AG059867, RF1AG064312). The on-going projects in our group are aimed to understand the physiological impacts of Alzheimer's disease, and to develop cost-efficient, non-invasive biomarkers for predicting and monitoring the progression of the disease.
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
to make corrections and additions.
(GAO , LEI)
Sep 15, 2020 - May 31, 2022
Circadian Multiscale Activity Regulation and the Risk for Delirium in Elderly Hospitalized Patients
Role Description: The goal of this project is to determine whether the multiscale regulation of motor activity can be a sensitive biomarker of delirium in the elderly.
Sep 1, 2020 - Aug 31, 2023
Circadian regulation, autonomic function and Alzheimer’s disease
Role Description: Circadian regulation, autonomic function and Alzheimer’s disease
BrightFocus Foundation A2020886S
Co-In (PI: Peng Li)
The goal of this project is to determine the roles of circadian dysregulation and autonomic dysfunction in the development/progression of AD utilizing novel circadian and autonomic measures derived from nonlinear analyses.
Sep 1, 2020 - Aug 31, 2022
Timing of Physical Activity on Cardiometabolic Health Outcomes
Role Description: The goal of this project is to study the relationship between timing of physical activity and physical activity-induced cardiometabolic outcomes in humans, with the goal of providing mechanistic insights to design lifestyle interventions to improve the efficacy of physical activity.
Feb 1, 2020 - Sep 30, 2020
Foundation in Anesthesia Research and Education (FAER)
Circadian/Sleep Disturbances and Systemic Inflammation in the Development of Delirium
Role Description: The goal of this project is to determine the long-term relationship between circadian/sleep disturbance and delirium.
Sep 1, 2019 - Mar 31, 2024
Integrative Motor Activity Biomarker for the Risk of Alzheimer's Risk
Role: Principal Investigator
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