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Kun Hu, Ph.D.

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Biography
Sun Yat-sen University , Guangzhou, PRCBS07/1995Material Science, Physics
University of Rhode Island, Kingston, RI, USAMS05/1999Quantum Physics
Boston University, Boston, MA, USAPhD02/2005Statistical Physics, Nonlinear Dynamics)
Beth Israel Deaconess Medical Center, Boston, MA, USAPostdoctoral11/2007Gerontology, Cardiovascular Physiology
Brigham & Women's Hospital, Boston, MA, USAPostdoctoral11/2007Circadian Physiology
1995
B.S. Thesis award
2003
Travel Award for Annual Meeting
2005
Travel Award for Annual Meeting
2006
Research Merit Trainee Travel Award
2006
Travel Grant for Workshop "Short-term Cardiovascular-Respiratory Control Mechanisms"
2007
Honorable Mention Abstract award
2008
Investigator Award
2008
Young Investigator
2015
Chair's Research Award (Department of Medicine)
2016
The Thousand Plan for Young Scholars (Selected but withdrawn)
2016
Innovation Discovery Award

Overview
I obtained my doctoral training in statistical physics with a specific focus on nonlinear dynamic analysis and fractal physiology. During the first 5 years of my postdoctoral training, I have essentially involved in human experimental studies in two laboratories: Medical Chronobiology Program under the supervision of Dr. Steven Shea and Dr. Frank Scheer in the Division of Sleep and Circadian Disorders at BWH (sleep/circadian physiology); and SAFE (Syncope and Falls in the Elderly) Laboratory under the supervision of Dr. Vera Novak in the Division of Gerontology at Beth Israel Deaconess Medical Center (BIDMC) (for aging research). Between 2009-2011, I continued my advanced training in sleep/circadian physiology at BWH while learning about animal models involving neural lesions and gene knockouts in Dr. Clifford Saper’s lab in the Department of Neurology at BIDMC and in system biology under the guidance of Prof. Walter Fontana in the Department of System Biology at Harvard University.

With my multidisciplinary training, I have been promoting the application of the concepts/methods derived from statistical physics and nonlinear dynamics in medicine during the last 16 years. To foster such translational research in sleep medicine, I established Medical Biodynamics Program (MBP) in the Division of Sleep Medicine at HMS (https://sleep.hms.harvard.edu/research/labs-divisions/medical-biodynamics-program-mbp). My research over the last decade years has been continuously funded by the NIH (K99 HL102241, R00 HL102241, R01AG048108, RF1AG059867, RF1AG064312). The on-going projects in our group are aimed to understand the physiological impacts of Alzheimer's disease, and to develop cost-efficient, non-invasive biomarkers for predicting and monitoring the progression of the disease.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03AG067985 (GAO , LEI) Sep 15, 2020 - May 31, 2022
    NIH
    Circadian Multiscale Activity Regulation and the Risk for Delirium in Elderly Hospitalized Patients
    Role Description: The goal of this project is to determine whether the multiscale regulation of motor activity can be a sensitive biomarker of delirium in the elderly.
    Role: Mentor
  2. A2020886S (Peng Li) Sep 1, 2020 - Aug 31, 2023
    BrightFocus Foundation
    Circadian regulation, autonomic function and Alzheimer’s disease
    Role Description: Circadian regulation, autonomic function and Alzheimer’s disease BrightFocus Foundation A2020886S Co-In (PI: Peng Li) The goal of this project is to determine the roles of circadian dysregulation and autonomic dysfunction in the development/progression of AD utilizing novel circadian and autonomic measures derived from nonlinear analyses.
    Role: Co-Investigator
  3. K99HL148500 (QIAN, JINGYI) Sep 1, 2020 - Aug 31, 2022
    NIH
    Timing of Physical Activity on Cardiometabolic Health Outcomes
    Role Description: The goal of this project is to study the relationship between timing of physical activity and physical activity-induced cardiometabolic outcomes in humans, with the goal of providing mechanistic insights to design lifestyle interventions to improve the efficacy of physical activity.
    Role: Co-mentor
  4. MRTG-02-15-2020 (Lei Gao) Feb 1, 2020 - Sep 30, 2020
    Foundation in Anesthesia Research and Education (FAER)
    Circadian/Sleep Disturbances and Systemic Inflammation in the Development of Delirium
    Role Description: The goal of this project is to determine the long-term relationship between circadian/sleep disturbance and delirium.
    Role: Mentor
  5. RF1AG064312 (HU, KUN) Sep 1, 2019 - Mar 31, 2024
    NIH
    Integrative Motor Activity Biomarker for the Risk of Alzheimer's Risk
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Qian J, Walkup MP, Chen SH, Brubaker PH, Bond DS, Richey PA, Jakicic JM, Hu K, Scheer FAJL, Middelbeek RJW. Association of Objectively Measured Timing of Physical Activity Bouts With Cardiovascular Health in Type 2 Diabetes. Diabetes Care. 2021 04; 44(4):1046-1054. PMID: 33597215.
    Citations: 1     Fields:    Translation:Humans
  2. Gao L, Gaba A, Cui L, Yang HW, Saxena R, Scheer FAJL, Akeju O, Rutter MK, Lo MT, Hu K, Li P. Resting Heartbeat Complexity Predicts All-Cause and Cardiorespiratory Mortality in Middle- to Older-Aged Adults From the UK Biobank. J Am Heart Assoc. 2021 02 02; 10(3):e018483. PMID: 33461311.
    Citations: 1     Fields:    Translation:Humans
  3. Arredondo-Amador M, Zambrano C, Kulyté A, Luján J, Hu K, Sánchez de Medina F, Scheer FAJL, Arner P, Ryden M, Martínez-Augustin O, Garaulet M. Circadian Rhythms in Hormone-sensitive Lipase in Human Adipose Tissue: Relationship to Meal Timing and Fasting Duration. J Clin Endocrinol Metab. 2020 12 01; 105(12). PMID: 32725188.
    Citations: 2     Fields:    Translation:Humans
  4. Gao L, Lim ASP, Wong PM, Gaba A, Cui L, Yu L, Buchman AS, Bennett DA, Hu K, Li P. Fragmentation of Rest/Activity Patterns in Community-Based Elderly Individuals Predicts Incident Heart Failure. Nat Sci Sleep. 2020; 12:299-307. PMID: 32581616.
    Citations: 2     
  5. Qian J, Scheer FA, Hu K, Shea SA. The circadian system modulates the rate of recovery of systolic blood pressure after exercise in humans. Sleep. 2020 04 15; 43(4). PMID: 31616941.
    Citations: 4     Fields:    Translation:Humans
  6. Knapen SE, Li P, Riemersma-van der Lek RF, Verkooijen S, Boks MPM, Schoevers RA, Scheer FAJL, Hu K. Fractal biomarker of activity in patients with bipolar disorder. Psychol Med. 2021 07; 51(9):1562-1569. PMID: 32234100.
    Citations: 2     Fields:    
  7. Butler MP, Thosar SS, Smales C, DeYoung PN, Wu H, Hussain MV, Morimoto M, Hu K, Scheer FAJL, Shea SA. Effects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis. Chronobiol Int. 2020 06; 37(6):856-866. PMID: 32192382.
    Citations: 2     Fields:    Translation:Humans
  8. Li P, Lim ASP, Gao L, Hu C, Yu L, Bennett DA, Buchman AS, Hu K. More random motor activity fluctuations predict incident frailty, disability, and mortality. Sci Transl Med. 2019 10 30; 11(516). PMID: 31666398.
    Citations: 11     Fields:    Translation:Humans
  9. Li P, Yu L, Yang J, Lo MT, Hu C, Buchman AS, Bennett DA, Hu K. Interaction between the progression of Alzheimer's disease and fractal degradation. Neurobiol Aging. 2019 11; 83:21-30. PMID: 31585364.
    Citations: 5     Fields:    Translation:Humans
  10. Gao L, Li P, Hu C, To T, Patxot M, Falvey B, Wong PM, Scheer FAJL, Lin C, Lo MT, Hu K. Nocturnal heart rate variability moderates the association between sleep-wake regularity and mood in young adults. Sleep. 2019 05 01; 42(5). PMID: 30722058.
    Citations: 4     Fields:    Translation:Humans
  11. Scheer FAJL, Chellappa SL, Hu K, Shea SA. Impact of mental stress, the circadian system and their interaction on human cardiovascular function. Psychoneuroendocrinology. 2019 05; 103:125-129. PMID: 30682628.
    Citations: 3     Fields:    Translation:Humans
  12. Yang H, Jeng S, Young HV, Lin C, Wang Y, Hu K, Lo M. A Minimum Arclength Method for Removing Spikes in Empirical Mode Decomposition. IEEE Access. 2019; 7:13284-13294. View Publication.
  13. Wu JQ, Li P, Stavitsky Gilbert K, Hu K, Cronin-Golomb A. Circadian Rest-Activity Rhythms Predict Cognitive Function in Early Parkinson's Disease Independently of Sleep. Mov Disord Clin Pract. 2018 Nov-Dec; 5(6):614-619. PMID: 30637282.
    Citations: 9     
  14. Pittman-Polletta B, Hu K, Kocsis B. Subunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction. Sci Rep. 2018 08 02; 8(1):11588. PMID: 30072757.
    Citations: 7     Fields:    Translation:Animals
  15. Wang YH, Hu K, Lo MT. Uniform Phase Empirical Mode Decomposition: An Optimal Hybridization of Masking Signal and Ensemble Approaches. IEEE Access. 2018; 6:34819-34833. PMID: 31106103.
    Citations: 1     
  16. Li P, Yu L, Lim ASP, Buchman AS, Scheer FAJL, Shea SA, Schneider JA, Bennett DA, Hu K. Fractal regulation and incident Alzheimer's disease in elderly individuals. Alzheimers Dement. 2018 09; 14(9):1114-1125. PMID: 29733807.
    Citations: 11     Fields:    Translation:Humans
  17. Joustra SD, Gu C, Rohling JHT, Pickering L, Klose M, Hu K, Scheer FA, Feldt-Rasmussen U, Jennum PJ, Pereira AM, Biermasz NR, Meijer JH. Decrease in scale invariance of activity fluctuations with aging and in patients with suprasellar tumors. Chronobiol Int. 2018 03; 35(3):368-377. PMID: 29182371.
    Citations: 1     Fields:    Translation:Humans
  18. Lo MT, Bandin C, Yang HW, Scheer FAJL, Hu K, Garaulet M. CLOCK 3111T/C genetic variant influences the daily rhythm of autonomic nervous function: relevance to body weight control. Int J Obes (Lond). 2018 02; 42(2):190-197. PMID: 28736443.
    Citations: 2     Fields:    Translation:Humans
  19. Li P, Morris CJ, Patxot M, Yugay T, Mistretta J, Purvis TE, Scheer FAJL, Hu K. Reduced Tolerance to Night Shift in Chronic Shift Workers: Insight From Fractal Regulation. Sleep. 2017 07 01; 40(7). PMID: 28838129.
    Citations: 10     Fields:    Translation:Humans
  20. Morris CJ, Purvis TE, Mistretta J, Hu K, Scheer FAJL. Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers. J Biol Rhythms. 2017 04; 32(2):154-164. PMID: 28347188.
    Citations: 35     Fields:    Translation:Humans
  21. Li P, To T, Chiang WY, Escobar C, Buijs RM, Hu K. Fractal Regulation in Temporal Activity Fluctuations: A Biomarker for Circadian Control and Beyond. JSM Biomark. 2017; 3(1). PMID: 28553673.
    Citations: 4     
  22. Lin C, Chang YC, Cheng YC, Lai PJ, Yeh CH, Hsieh WH, Hu K, Wu JT, Lee HH, Lo MT, Ho YL. Probing the Fractal Pattern of Heartbeats in Drosophila Pupae by Visible Optical Recording System. Sci Rep. 2016 08 18; 6:31950. PMID: 27535299.
    Citations:    Fields:    Translation:AnimalsCells
  23. Yeh CH, Lo MT, Hu K. Spurious cross-frequency amplitude-amplitude coupling in nonstationary, nonlinear signals. Physica A. 2016 Jul 15; 454:143-150. PMID: 27103757.
    Citations: 8     
  24. Hu K, Riemersma-van der Lek RF, Patxot M, Li P, Shea SA, Scheer FA, Van Someren EJ. Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results From a 3.5-Year, Longitudinal Randomized Controlled Trial. Sci Rep. 2016 06 13; 6:27742. PMID: 27292543.
    Citations: 12     Fields:    Translation:Humans
  25. Lo MT, Chiang WY, Hsieh WH, Escobar C, Buijs RM, Hu K. Interactive Effects of Dorsomedial Hypothalamic Nucleus and Time-Restricted Feeding on Fractal Motor Activity Regulation. Front Physiol. 2016; 7:174. PMID: 27242548.
    Citations: 7     
  26. Huang NE, Hu K, Yang AC, Chang HC, Jia D, Liang WK, Yeh JR, Kao CL, Juan CH, Peng CK, Meijer JH, Wang YH, Long SR, Wu Z. On Holo-Hilbert spectral analysis: a full informational spectral representation for nonlinear and non-stationary data. Philos Trans A Math Phys Eng Sci. 2016 Apr 13; 374(2065):20150206. PMID: 26953180.
    Citations: 10     Fields:    
  27. Morris CJ, Purvis TE, Hu K, Scheer FA. Circadian misalignment increases cardiovascular disease risk factors in humans. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1402-11. PMID: 26858430.
    Citations: 133     Fields:    Translation:Humans
  28. Chen MC, Chiang WY, Yugay T, Patxot M, Özçivit IB, Hu K, Lu J. Anterior Insula Regulates Multiscale Temporal Organization of Sleep and Wake Activity. J Biol Rhythms. 2016 Apr; 31(2):182-93. PMID: 26825619.
    Citations: 8     Fields:    Translation:Animals
  29. Yeh CH, Hung CY, Wang YH, Hsu WT, Chang YC, Yeh JR, Lee PL, Hu K, Kang JH, Lo MT. Novel application of a Wii remote to measure spasticity with the pendulum test: Proof of concept. Gait Posture. 2016 Jan; 43:70-5. PMID: 26669955.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  30. Holmes ML, Manor B, Hsieh WH, Hu K, Lipsitz LA, Li L. Tai Chi training reduced coupling between respiration and postural control. Neurosci Lett. 2016 Jan 01; 610:60-5. PMID: 26518241.
    Citations: 3     Fields:    Translation:Humans
  31. Wang JL, Lim AS, Chiang WY, Hsieh WH, Lo MT, Schneider JA, Buchman AS, Bennett DA, Hu K, Saper CB. Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans. Ann Neurol. 2015 Aug; 78(2):317-22. PMID: 25921596.
    Citations: 59     Fields:    Translation:HumansCells
  32. Lo MT, Chang YC, Lin C, Young HW, Lin YH, Ho YL, Peng CK, Hu K. Outlier-resilient complexity analysis of heartbeat dynamics. Sci Rep. 2015 Mar 06; 5:8836. PMID: 25744292.
    Citations: 6     Fields:    Translation:Humans
  33. Gu C, Coomans CP, Hu K, Scheer FA, Stanley HE, Meijer JH. Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2320-4. PMID: 25675516.
    Citations: 17     Fields:    Translation:HumansAnimals
  34. Hsieh WH, Escobar C, Yugay T, Lo MT, Pittman-Polletta B, Salgado-Delgado R, Scheer FA, Shea SA, Buijs RM, Hu K. Simulated shift work in rats perturbs multiscale regulation of locomotor activity. J R Soc Interface. 2014 Jul 06; 11(96). PMID: 24829282.
    Citations: 13     Fields:    Translation:Animals
  35. Wang Y, Yeh C, Young HV, Hu K, Lo M. On the computational complexity of the empirical mode decomposition algorithm. Physica A. 2014; 400:159-167. View Publication.
  36. Pittman-Polletta B, Hsieh WH, Kaur S, Lo MT, Hu K. Detecting phase-amplitude coupling with high frequency resolution using adaptive decompositions. J Neurosci Methods. 2014 Apr 15; 226:15-32. PMID: 24452055.
    Citations: 10     Fields:    Translation:Animals
  37. Zhou J, Manor B, Liu D, Hu K, Zhang J, Fang J. The complexity of standing postural control in older adults: a modified detrended fluctuation analysis based upon the empirical mode decomposition algorithm. PLoS One. 2013; 8(5):e62585. PMID: 23650518.
    Citations: 9     Fields:    Translation:Humans
  38. Pittman-Polletta BR, Scheer FA, Butler MP, Shea SA, Hu K. The role of the circadian system in fractal neurophysiological control. Biol Rev Camb Philos Soc. 2013 Nov; 88(4):873-94. PMID: 23573942.
    Citations: 25     Fields:    Translation:Animals
  39. Hu K, Harper DG, Shea SA, Stopa EG, Scheer FA. Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia. Sci Rep. 2013; 3:2229. PMID: 23863985.
    Citations: 30     Fields:    Translation:HumansCells
  40. Hu K, Meijer JH, Shea SA, vanderLeest HT, Pittman-Polletta B, Houben T, van Oosterhout F, Deboer T, Scheer FA. Fractal patterns of neural activity exist within the suprachiasmatic nucleus and require extrinsic network interactions. PLoS One. 2012; 7(11):e48927. PMID: 23185285.
    Citations: 18     Fields:    Translation:AnimalsCells
  41. Aoi MC, Hu K, Lo MT, Selim M, Olufsen MS, Novak V. Impaired cerebral autoregulation is associated with brain atrophy and worse functional status in chronic ischemic stroke. PLoS One. 2012; 7(10):e46794. PMID: 23071639.
    Citations: 20     Fields:    Translation:Humans
  42. Hu K, Lo MT, Peng CK, Liu Y, Novak V. A nonlinear dynamic approach reveals a long-term stroke effect on cerebral blood flow regulation at multiple time scales. PLoS Comput Biol. 2012; 8(7):e1002601. PMID: 22807666.
    Citations: 13     Fields:    Translation:Humans
  43. Manor BD, Hu K, Peng CK, Lipsitz LA, Novak V. Posturo-respiratory synchronization: effects of aging and stroke. Gait Posture. 2012 Jun; 36(2):254-9. PMID: 22475726.
    Citations: 7     Fields:    Translation:HumansCells
  44. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Feb 22; 483(7387):96-9. PMID: 22367544.
    Citations: 144     Fields:    Translation:AnimalsCells
  45. Rissanen SM, Kankaanpää M, Tarvainen MP, Novak V, Novak P, Hu K, Manor B, Airaksinen O, Karjalainen PA. Analysis of EMG and acceleration signals for quantifying the effects of deep brain stimulation in Parkinson's disease. IEEE Trans Biomed Eng. 2011 Sep; 58(9):2545-53. PMID: 21672674.
    Citations: 9     Fields:    Translation:Humans
  46. Shea SA, Hilton MF, Hu K, Scheer FA. Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening. Circ Res. 2011 Apr 15; 108(8):980-4. PMID: 21474818.
    Citations: 58     Fields:    Translation:Humans
  47. Hu K, Scheer FA, Laker M, Smales C, Shea SA. Endogenous circadian rhythm in vasovagal response to head-up tilt. Circulation. 2011 Mar 08; 123(9):961-70. PMID: 21339480.
    Citations: 31     Fields:    Translation:Humans
  48. Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hilton MF, Shea SA. Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20541-6. PMID: 21059915.
    Citations: 101     Fields:    Translation:Humans
  49. Manor B, Costa MD, Hu K, Newton E, Starobinets O, Kang HG, Peng CK, Novak V, Lipsitz LA. Physiological complexity and system adaptability: evidence from postural control dynamics of older adults. J Appl Physiol (1985). 2010 Dec; 109(6):1786-91. PMID: 20947715.
    Citations: 79     Fields:    Translation:Humans
  50. Lin LY, Lo MT, Ko PC, Lin C, Chiang WC, Liu YB, Hu K, Lin JL, Chen WJ, Ma MH. Detrended fluctuation analysis predicts successful defibrillation for out-of-hospital ventricular fibrillation cardiac arrest. Resuscitation. 2010 Mar; 81(3):297-301. PMID: 20071067.
    Citations: 17     Fields:    Translation:Humans
  51. Novak V, Hu K, Desrochers L, Novak P, Caplan L, Lipsitz L, Selim M. Cerebral flow velocities during daily activities depend on blood pressure in patients with chronic ischemic infarctions. Stroke. 2010 Jan; 41(1):61-6. PMID: 19959536.
    Citations: 13     Fields:    Translation:Humans
  52. Lo MT, Novak V, Peng CK, Liu Y, Hu K. Nonlinear phase interaction between nonstationary signals: a comparison study of methods based on Hilbert-Huang and Fourier transforms. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Jun; 79(6 Pt 1):061924. PMID: 19658541.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  53. Novak V, Haertle M, Zhao P, Hu K, Munshi M, Novak P, Abduljalil A, Alsop D. White matter hyperintensities and dynamics of postural control. Magn Reson Imaging. 2009 Jul; 27(6):752-9. PMID: 19250785.
    Citations: 19     Fields:    Translation:HumansCells
  54. Zhao P, Alsop DC, Abduljalil A, Selim M, Lipsitz L, Novak P, Caplan L, Hu K, Novak V. Vasoreactivity and peri-infarct hyperintensities in stroke. Neurology. 2009 Feb 17; 72(7):643-9. PMID: 19221298.
    Citations: 26     Fields:    Translation:Humans
  55. Hu K, Lo MT, Peng CK, Novak V, Schmidt EA, Kumar A, Czosnyka M. Nonlinear pressure-flow relationship is able to detect asymmetry of brain blood circulation associated with midline shift. J Neurotrauma. 2009 Feb 11; 26(2):227-33. PMID: 19196074.
    Citations: 11     Fields:    Translation:Humans
  56. Hu K, Van Someren EJ, Shea SA, Scheer FA. Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2490-4. PMID: 19202078.
    Citations: 77     Fields:    Translation:Humans
  57. Shea SA, Hu K, Scheer FA. Endogenous circadian rhythm of activity in humans. Sleep. 2008; 31:A46.
  58. Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hahn M, Laker MD, Patel Y, Smales C, Shea SA. Influence of endogenous circadian system, physical exercise, and their interaction on cardiovascular risk factors. Sleep. 2008; 31:A46.
  59. Hu K, Van Someren E, Shea SA, Scheer FA. Reduction of scale-invariant activity control with aging and Alzheimer's disease: Possible involvement of the circadian pacemaker in multiscale regulation of human activity. Sleep. 2008; 31:A46-A47.
  60. Hu K, Scheer FA, Buijs RM, Shea SA. The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats. Cardiovasc Res. 2008 Oct 01; 80(1):62-8. PMID: 18539630.
    Citations: 11     Fields:    Translation:HumansAnimals
  61. Hu K, Scheer FA, Evoniuk H, Kelly E, Laker M, Smales C, Shea SA. Influences of postural tilt stress and the circadian system on cardiovascular risk factors. Sleep. 2008; 31:A25.
  62. Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Doamekpor LA, Laker MD, Patel Y, Smales C, Shea SA . Additive influences of the endogenous circadian system and mental stress on cardiovascular risk factors. Sleep. 2008; 31:A51-A52.
  63. Hu K, Scheer FA, Buijs RM, Shea SA. The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours. J Biol Rhythms. 2008 Jun; 23(3):265-73. PMID: 18487418.
    Citations: 14     Fields:    Translation:Animals
  64. Hu K, Peng CK, Huang NE, Wu Z, Lipsitz LA, Cavallerano J, Novak V. Altered Phase Interactions between Spontaneous Blood Pressure and Flow Fluctuations in Type 2 Diabetes Mellitus: Nonlinear Assessment of Cerebral Autoregulation. Physica A. 2008 Apr 01; 387(10):2279-2292. PMID: 18432311.
    Citations: 24     
  65. Hu K, Peng CK, Czosnyka M, Zhao P, Novak V. Nonlinear assessment of cerebral autoregulation from spontaneous blood pressure and cerebral blood flow fluctuations. Cardiovasc Eng. 2008 Mar; 8(1):60-71. PMID: 18080758.
    Citations: 31     Fields:    Translation:Humans
  66. Lo M-T, Hu K., Liu Y, Peng CK, Novak V. Multimodal Pressure Flow Analysis Enables Assessment of Cerebral Autoregulation Dynamics During Baseline Resting Conditions. Journal on Advances in Signal Processing. 2008; 785243.
  67. Lo MT, Hu K, Liu Y, Peng CK, Novak V. Multimodal Pressure Flow Analysis: Application of Hilbert Huang Transform in Cerebral Blood Flow Regulation. EURASIP J Adv Signal Process. 2008; 2008:785243. PMID: 18725996.
    Citations: 20     
  68. Ivanov PCh, Hu K, Hilton MF, Shea SA, Stanley HE. Endogenous circadian rhythm in human motor activity uncoupled from circadian influences on cardiac dynamics. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20702-7. PMID: 18093917.
    Citations: 48     Fields:    Translation:Humans
  69. Hu K, Scheer FA, Ivanov PCh, Buijs RM, Shea SA. The suprachiasmatic nucleus functions beyond circadian rhythm generation. Neuroscience. 2007 Nov 09; 149(3):508-17. PMID: 17920204.
    Citations: 47     Fields:    Translation:HumansAnimals
  70. Last D, Alsop DC, Abduljalil AM, Marquis RP, de Bazelaire C, Hu K, Cavallerano J, Novak V. Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity. Diabetes Care. 2007 May; 30(5):1193-9. PMID: 17290035.
    Citations: 98     Fields:    Translation:Humans
  71. Hu K, Peng CK, Czosnyka M, Novak V . Assessment of impairment of dynamic cerebral autoregulation after traumatic brain injury using multimodal pressure flow analysis. Neurology. 2007; 68(12):A392 Suppl.1.
  72. Hu K, Peng CK, Huang N, Wu Z, Lipsitz LA, Novak V. Assessment Of Impaired Cerebral Blood Flow Regulation in Type 2 Diabetes Mellitus Using Multimodal Pressure Flow Analysis. Diabetes. 2007; 56:A585 Suppl. 1.
  73. Shea SA, Hu K, Buijs RM, Scheer FAJL. Lesioning the suprachiasmatic nucleus abolishes ultradian rhythms of locomotor activity in rats. SLEEP. 2007; 30:A58 168 Suppl. S.
  74. Selim MH, Jones RN, Hu K, Novak P, Novak V. Gender differences in cerebral hemodynamics in patients with diabetes, hypertension, and stroke: A transcranial Doppler ultrasound study. Stroke. 2007; 38:567.
  75. Hu K, Scheer FAJL, Buijs RM, Shea SA. Effect of lesioning the suprachiasmatic nucleus on fractal pattern of heart rate fluctuations. SLEEP. 2007; 30:A64 186 Suppl. S.
  76. Novak V, Hu K, Vyas M, Lipsitz LA. Cardiolocomotor coupling in young and elderly people. J Gerontol A Biol Sci Med Sci. 2007 Jan; 62(1):86-92. PMID: 17301044.
    Citations: 12     Fields:    Translation:Humans
  77. Zhao P, Haertle M, Hu K, Larose S, Abdulajlil A, Alsop D, Novak V. Effects of white matter hyperintensities on balance in elderly with type 2 diabetes and hypertension. Diabetes. 2007; 56:A171 Suppl. 1.
  78. Novak V, Last D, Alsop DC, Abduljalil AM, Hu K, Lepicovsky L, Cavallerano J, Lipsitz LA. Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes. Diabetes Care. 2006 Jul; 29(7):1529-34. PMID: 16801574.
    Citations: 66     Fields:    Translation:Humans
  79. Xu L, Chen Z, Hu K, Stanley HE, Ivanov PCh. Spurious detection of phase synchronization in coupled nonlinear oscillators. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jun; 73(6 Pt 2):065201. PMID: 16906897.
    Citations: 19     Fields:    
  80. Chen Z, Hu K, Stanley HE, Novak V, Ivanov PCh. Cross-correlation of instantaneous phase increments in pressure-flow fluctuations: applications to cerebral autoregulation. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Mar; 73(3 Pt 1):031915. PMID: 16605566.
    Citations: 20     Fields:    Translation:HumansCTClinical Trials
  81. Hu K, Scheer FAJL, Ivanov PCh, Buijs RM, Shea SA. Intrinsic scale-invariant patterns of locomotor activity: Influence of the circadian pacemaker across a wide range of time scales - Spanning 4-24 hours. Sleep. 2006; 29:A64 190 Suppl. S.
  82. Hu K, Peng CK, Last D, Novak V. Age and gender effects on postural control dynamics assessed by stabilogram-diffusion analysis. Diabetes. 2006; 55:A579.
  83. Hu K, Hilton MF, Ayers R, Ivanov PCh, Shea SA. An endogenous circadian rhythm in an index of cardiac vulnerability confirmed with a constant routine protocol. Sleep. 2006; 29:A68 202 Suppl. S.
  84. Robles CA, Hu K, Last D, Lepicovsky L, Novak P, Novak V. Effects of type 2 diabetes mellitus on foot pressure distribution during walking. Diabetes. 2006; 55:A543.
  85. Hessert MJ, Vyas M, Leach J, Hu K, Lipsitz LA, Novak V. Foot pressure distribution during walking in young and old adults. BMC Geriatr. 2005 May 19; 5:8. PMID: 15943881.
    Citations: 27     Fields:    Translation:Humans
  86. Xu L, Ivanov PCh, Hu K, Chen Z, Carbone A, Stanley HE. Quantifying signals with power-law correlations: a comparative study of detrended fluctuation analysis and detrended moving average techniques. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 May; 71(5 Pt 1):051101. PMID: 16089515.
    Citations: 32     Fields:    
  87. Hu K, Ivanov PCh, Chen Z, Stanley HE, Hilton MF, Shea SA. Circadian rhythms and fractal fluctuations in forearm motion. APS March Meeting, March 24, 2005; Los Angeles, CA. APS March Meeting, Los Angeles, CA. 2005; V22.00008.
  88. Chen Z, Hu K, Carpena P, Bernaola-Galvan P, Stanley HE, Ivanov PCh. Effect of nonlinear filters on detrended fluctuation analysis. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jan; 71(1 Pt 1):011104. PMID: 15697577.
    Citations: 25     Fields:    Translation:HumansAnimals
  89. Hu Kun. Statistical physics approaches to understanding physiological fluctuations. 2005.
  90. Hu K, Ivanov PCh, Hilton MF, Chen Z, Ayers RT, Stanley HE, Shea SA. Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18223-7. PMID: 15611476.
    Citations: 48     Fields:    Translation:Humans
  91. Angelini L, de Tommaso M, Guido M, Hu K, Ivanov PCh, Marinazzo D, Nardulli G, Nitti L, Pellicoro M, Pierro C, Stramaglia S. Steady-state visual evoked potentials and phase synchronization in migraine patients. Phys Rev Lett. 2004 Jul 16; 93(3):038103. PMID: 15323876.
    Citations: 21     Fields:    Translation:Humans
  92. Hu K, Ivanov PCh, Chen Z, Hilton MF, Stanley HE, Shea SA. Non-random fluctuations and multi-scale dynamics regulation of human activity. Physica A. 2004 Jun; 337(1-2):307-18. PMID: 15759365.
    Citations: 65     Translation:Humans
  93. Stramaglia S, Angelini L, Pellicoro M, Hu K, Ivanov PCh. EEG synchronization and migraine. APS March Meeting; Montreal, Quebec, Canada. 2004; W9.001.
  94. Ivanov PCh, Chen Z, Hu K, Stanley HE. Multiscale aspects of cardiac control. Physica A. 2004; 344:685-704.
  95. Ivanov PCh, Hu K, Dammers J, Fieseler T, Tass PA. Detection of hierarchies and complex networks in cerebral synchronization patterns. APS March Meeting, Austin, TX. 2003; N15.012.
  96. Hu K, Ivanov PCh, Chen Z, Hilton MF, Stanley HE, Shea SA. Novel multiscale regulation in human motor activity. Noise in Complex Systems and Stochastic Dynamics. 2003; 5110:235-43.
  97. Chen Z, Ivanov PCh, Hu K, Stanley HE, Novak V. Synchronization patterns in cerebral blood flow and peripheral blood pressure after a minor stroke. Noise in Complex Systems and Stochastic Dynamics. 2003; 5114:498-506.
  98. Chen Z, Ivanov PCh, Hu K, Stanley HE. Effect of nonstationarities on detrended fluctuation analysis. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Apr; 65(4 Pt 1):041107. PMID: 12005806.
    Citations: 114     Fields:    Translation:CellsPHPublic Health
  99. Hu K, Ivanov PC, Chen Z, Carpena P, Stanley HE. Effect of trends on detrended fluctuation analysis. Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Jul; 64(1 Pt 1):011114. PMID: 11461232.
    Citations: 120     Fields:    
  100. Xu XH, Fu RT, Hu K, Sun X, Yonemitsu K. Off-diagonal interactions and spin-density waves in polymers. Physical Review B. 1998; 58(14):9039-46.
  101. Karbach M, Hu K, Muller G, Tobochnik J. Computer simulations ---Introduction to the Bethe ansatz II. Computers in Physics. 1998; 12(6):565-73.
  102. Sun X, Xu XH, Hu K, Yonemitsu K. Effect of electron correlation on competition between BOW and SDW in polymer. Physics Letters A. 1998; 239(3):191-5.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.