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Hye Chang Rhim, M.D.

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Biography
2019
British Association of Sport & Exercise Medicine Annual Conference Poster Presentation First Place
2020
Korean Arthroscopy Society Best Paper Award

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Yoo TK, Rhim HC, Park SH, Park S, Lee JY. Relationship between physical fitness and arterial stiffness in Korean older adults. Medicine (Baltimore). 2022 Sep 23; 101(38):e30617. PMID: 36197273; PMCID: PMC9509115.
    Citations:    Fields:    
  2. Rhim HC, Tenforde A, Mohr L, Hollander K, Vogt L, Groneberg DA, Wilke J. Association between physical activity and musculoskeletal pain: an analysis of international data from the ASAP survey. BMJ Open. 2022 09 19; 12(9):e059525. PMID: 36123076; PMCID: PMC9486184.
    Citations:    Fields:    
  3. Rhim HC, Gureck AE, Jang KM. Acute Obturator Externus Injury in Professional Soccer Players: A Case Series. Medicina (Kaunas). 2022 Aug 23; 58(9). PMID: 36143822; PMCID: PMC9504638.
    Citations:    Fields:    
  4. Park JG, Han SB, Rhim HC, Jeon OH, Jang KM. Anatomy of the anterolateral ligament of the knee joint. World J Clin Cases. 2022 Jul 26; 10(21):7215-7223. PMID: 36158026.
    Citations:    
  5. Yoo TK, Rhim HC, Lee YT, Yoon KJ, Park CH. Relationship between hyperhomocysteinemia and coexisting obesity with low skeletal muscle mass in asymptomatic adult population. Sci Rep. 2022 07 20; 12(1):12439. PMID: 35858996; PMCID: PMC9300668.
    Citations:    Fields:    Translation:Humans
  6. Rahman MA, Rahman MDH, Mamun-Or-Rashid ANM, Hwang H, Chung S, Kim B, Rhim H. Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease. Biomedicines. 2022 Apr 29; 10(5). PMID: 35625764; PMCID: PMC9138936.
    Citations: 1     
  7. Rhim HC, Park CM, Kim DH. Association of social determinants, multimorbidity, and functional status with mortality after hospitalization for pneumonia in South Korea. J Am Geriatr Soc. 2022 08; 70(8):2428-2431. PMID: 35415839.
    Citations:    Fields:    
  8. Rhim HC, Kwon J, Park J, Borg-Stein J, Tenforde AS. A Systematic Review of Systematic Reviews on the Epidemiology, Evaluation, and Treatment of Plantar Fasciitis. Life (Basel). 2021 Nov 24; 11(12). PMID: 34947818.
    Citations: 3     
  9. Lee YM, Lee J, Rhim HC, Park H. A Preliminary Study on Uncovering Medical Students' Unprofessional Behaviors from YouTube Videos. J Korean Med Sci. 2021 Nov 01; 36(42):e296. PMID: 34725980.
    Citations: 2     Fields:    Translation:Humans
  10. Choi SH, Lee RM, Cho HS, Hwang SH, Hwang HI, Rhim H, Kim HC, Kim DG, Cho IH, Nah SY. Visualization of the binding between gintonin, a Panax ginseng-derived LPA receptor ligand, and the LPA receptor subtypes and transactivation of the EGF receptor. J Ginseng Res. 2022 May; 46(3):348-356. PMID: 35600777; PMCID: PMC9120792.
    Citations: 1     
  11. Park CM, Kim W, Lee ES, Rhim HC, Cho KH, Kim JH, Kim DH. Comparison of Frailty Index to Pneumonia Severity Measures in Older Patients With Pneumonia. J Am Med Dir Assoc. 2022 01; 23(1):165-169. PMID: 34624243.
    Citations:    Fields:    Translation:Humans
  12. Rhim HC, Jeon OH, Han SB, Bae JH, Suh DW, Jang KM. Mesenchymal stem cells for enhancing biological healing after meniscal injuries. World J Stem Cells. 2021 Aug 26; 13(8):1005-1029. PMID: 34567422.
    Citations: 2     
  13. Mettler SK, Park J, Özbek O, Mettler LK, Ho PH, Rhim HC, Maathuis MH. The importance of timely contact tracing - A simulation study. Int J Infect Dis. 2021 Jul; 108:309-319. PMID: 33862210.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  14. Lee R, Lee BH, Choi SH, Cho YJ, Cho HS, Kim HC, Rhim H, Cho IH, Rhee MH, Nah SY. Effects of Gintonin-enriched fraction on the gene expression of six lysophosphatidic receptor subtypes. J Ginseng Res. 2021 Sep; 45(5):583-590. PMID: 34803428; PMCID: PMC8587509.
    Citations: 2     
  15. Lee JH, Jang KM, Kim E, Rhim HC, Kim HD. Static and Dynamic Quadriceps Stretching Exercises in Patients With Patellofemoral Pain: A Randomized Controlled Trial. Sports Health. 2021 Sep-Oct; 13(5):482-489. PMID: 33615901.
    Citations:    Fields:    Translation:Humans
  16. Park J, Rhim HC. Association between mental illness and COVID-19 in South Korea. Lancet Psychiatry. 2021 04; 8(4):270. PMID: 33617763.
    Citations:    Fields:    Translation:HumansCells
  17. Park JH, Rhyu IJ, Lim HK, Cha JH, Shin GJ, Rhim HC, Kim DH. Which Approach Is Most Optimal for Needle Electromyographic Examination of the Biceps Femoris Short Head: Medial or Lateral? Ann Rehabil Med. 2021 Feb; 45(1):42-48. PMID: 33557485.
    Citations:    
  18. Park CM, Kim W, Rhim HC, Lee ES, Kim JH, Cho KH, Kim DH. Frailty and hospitalization-associated disability after pneumonia: A prospective cohort study. BMC Geriatr. 2021 02 05; 21(1):111. PMID: 33546614.
    Citations: 6     Fields:    Translation:Humans
  19. Jang M, Choi SH, Choi JH, Oh J, Lee RM, Lee NE, Cho YJ, Rhim H, Kim HC, Cho IH, Nah SY. Ginseng gintonin attenuates the disruptions of brain microvascular permeability and microvascular endothelium junctional proteins in an APPswe/PSEN-1 double-transgenic mouse model of ?lzheimer's disease. Exp Ther Med. 2021 Apr; 21(4):310. PMID: 33717253; PMCID: PMC7885069.
    Citations: 2     
  20. Suh DK, Lee JH, Rhim HC, Cho IY, Han SB, Jang KM. Comparison of muscle strength and neuromuscular control up to 1 year after anterior cruciate ligament reconstruction between patients with dominant leg and non-dominant leg injuries. Knee. 2021 Mar; 29:15-25. PMID: 33524658.
    Citations: 3     Fields:    Translation:Humans
  21. Rhim HC, Lee JH, Lee SJ, Jeon JS, Kim G, Lee KY, Jang KM. Supervised Rehabilitation May Lead to Better Outcome than Home-Based Rehabilitation Up to 1 Year after Anterior Cruciate Ligament Reconstruction. Medicina (Kaunas). 2020 Dec 28; 57(1). PMID: 33379403.
    Citations: 2     Fields:    Translation:Humans
  22. Rhim HC, Cha JH, Cha J, Kim DH. Sonography-guided trigger point injections in abdominal myofascial pain syndrome. Medicine (Baltimore). 2020 Dec 04; 99(49):e23408. PMID: 33285730; PMCID: PMC7717795.
    Citations: 1     Fields:    Translation:Humans
  23. Tenforde AS, Rhim HC. Evidence-Based Physiatry: Treatment of Midportion Achilles Tendinopathy. Am J Phys Med Rehabil. 2020 12; 99(12):1189-1190. PMID: 32889865.
    Citations:    Fields:    Translation:Humans
  24. Rhim HC, Lee SJ, Jeon JS, Kim G, Lee KY, Lee JH, Jang KM. Effectiveness of modeling videos on psychological responses of patients following anterior cruciate ligament reconstruction: A pilot randomized trial. Medicine (Baltimore). 2020 Nov 06; 99(45):e23158. PMID: 33158001; PMCID: PMC7647531.
    Citations:    Fields:    Translation:Humans
  25. Rhim HC, Lee JH, Han SB, Shin KH, Suh DW, Jang KM. Role of the Triceps Surae Muscles in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Matched Case-Control Study. J Clin Med. 2020 Oct 07; 9(10). PMID: 33036346.
    Citations:    
  26. Rhim HC, Han H. Teaching online: foundational concepts of online learning and practical guidelines. Korean J Med Educ. 2020 Sep; 32(3):175-183. PMID: 32894921.
    Citations: 9     Fields:    Translation:Humans
  27. Park J, Park H, Lim JE, Rhim HC, Lee YM. Medical students' perspectives on recommencing clinical rotations during coronavirus disease 2019 at one institution in South Korea. Korean J Med Educ. 2020 Sep; 32(3):223-229. PMID: 32894923.
    Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
  28. Lee JH, Jang KM, Kim E, Rhim HC, Kim HD. Effects of Static and Dynamic Stretching With Strengthening Exercises in Patients With Patellofemoral Pain Who Have Inflexible Hamstrings: A Randomized Controlled Trial. Sports Health. 2021 Jan/Feb; 13(1):49-56. PMID: 32790575.
    Citations: 1     Fields:    Translation:Humans
  29. Rhim HC, Kim SJ, Jeon JS, Nam HW, Jang KM. Prevalence and risk factors of running-related injuries in Korean non-elite runners: a cross-sectional survey study. J Sports Med Phys Fitness. 2021 Mar; 61(3):413-419. PMID: 32744044.
    Citations: 1     Fields:    Translation:Humans
  30. Hwang H, Szucs MJ, Ding LJ, Allen A, Ren X, Haensgen H, Gao F, Rhim H, Andrade A, Pan JQ, Carr SA, Ahmad R, Xu W. Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome. Biol Psychiatry. 2021 02 01; 89(3):256-269. PMID: 33032807; PMCID: PMC9258036.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  31. Rhim HC, Kim MS, Choi S, Tenforde AS. Comparative Efficacy and Tolerability of Nonsurgical Therapies for the Treatment of Midportion Achilles Tendinopathy: A Systematic Review With Network Meta-analysis. Orthop J Sports Med. 2020 Jul; 8(7):2325967120930567. PMID: 32728589; PMCID: PMC7366412.
    Citations: 7     
  32. Lee R, Lee NE, Choi SH, Nam SM, Kim HC, Rhim H, Cho IH, Hwang SH, Nah SY. Effects of gintonin-enriched fraction on hippocampal gene expressions. Integr Med Res. 2021 Jun; 10(2):100475. PMID: 33134079; PMCID: PMC7588706.
    Citations: 2     
  33. Choi SH, Lee R, Nam SM, Kim DG, Cho IH, Kim HC, Cho Y, Rhim H, Nah SY. Ginseng gintonin, aging societies, and geriatric brain diseases. Integr Med Res. 2021 Mar; 10(1):100450. PMID: 32817818; PMCID: PMC7426447.
    Citations: 8     
  34. Nam SM, Choi JH, Choi SH, Cho HJ, Cho YJ, Rhim H, Kim HC, Cho IH, Kim DG, Nah SY. Ginseng gintonin alleviates neurological symptoms in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis through lysophosphatidic acid 1 receptor. J Ginseng Res. 2021 May; 45(3):390-400. PMID: 34025132; PMCID: PMC8134849.
    Citations: 1     
  35. Park J, Rhim HC. Consequences of coronavirus disease 2019 on international medical graduates and students applying to residencies in the United States. Korean J Med Educ. 2020 06; 32(2):91-95. PMID: 32312022.
    Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
  36. Kim MS, Rhim HC, Park A, Kim H, Han KM, Patkar AA, Pae CU, Han C. Comparative efficacy and acceptability of pharmacological interventions for the treatment and prevention of delirium: A systematic review and network meta-analysis. J Psychiatr Res. 2020 06; 125:164-176. PMID: 32302794.
    Citations: 8     Fields:    Translation:Humans
  37. Rhim HC, Kim SJ, Park J, Jang KM. Effect of citrulline on post-exercise rating of perceived exertion, muscle soreness, and blood lactate levels: A systematic review and meta-analysis. J Sport Health Sci. 2020 12; 9(6):553-561. PMID: 33308806.
    Citations: 6     Fields:    Translation:Humans
  38. Choi SH, Lee NE, Cho HJ, Lee RM, Rhim H, Kim HC, Han M, Lee EH, Park J, Nah SY. Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors. J Ginseng Res. 2021 Mar; 45(2):264-272. PMID: 33841007; PMCID: PMC8020287.
    Citations: 2     
  39. Rhim H, Kim YH, Kim MG, Jang KM, Suh SW. Magnetic Resonance Imaging Findings of Knees and Spines in Recreational Runners who Completed 1000 Marathons. Cureus. 2019 Dec 14; 11(12):e6382. PMID: 31938660.
    Citations: 1     
  40. Lee NE, Park SD, Hwang H, Choi SH, Lee RM, Nam SM, Choi JH, Rhim H, Cho IH, Kim HC, Hwang SH, Nah SY. Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study. J Ginseng Res. 2020 Jan; 44(1):168-177. PMID: 32095099; PMCID: PMC7033365.
    Citations: 4     
  41. Rhim HC, Kim MS, Park YJ, Choi WS, Park HK, Kim HG, Kim A, Paick SH. The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis. J Sex Med. 2019 02; 16(2):223-234. PMID: 30770070.
    Citations: 8     Fields:    Translation:Humans
  42. Nam SM, Hwang H, Seo M, Chang BJ, Kim HJ, Choi SH, Rhim H, Kim HC, Cho IH, Nah SY. Gintonin Attenuates D-Galactose-Induced Hippocampal Senescence by Improving Long-Term Hippocampal Potentiation, Neurogenesis, and Cognitive Functions. Gerontology. 2018; 64(6):562-575. PMID: 30138913.
    Citations: 11     Fields:    Translation:AnimalsCells
  43. Choi SH, Kim HJ, Cho HJ, Park SD, Lee NE, Hwang SH, Cho IH, Hwang H, Rhim H, Kim HC, Nah SY. Gintonin, a Ginseng-Derived Exogenous Lysophosphatidic Acid Receptor Ligand, Protects Astrocytes from Hypoxic and Re-oxygenation Stresses Through Stimulation of Astrocytic Glycogenolysis. Mol Neurobiol. 2019 May; 56(5):3280-3294. PMID: 30117105.
    Citations: 8     Fields:    Translation:AnimalsCells
  44. Kim Y, Kim H, Lee J, Lee JK, Min SJ, Seong J, Rhim H, Tae J, Lee HJ, Choo H. Discovery of ß-Arrestin Biased Ligands of 5-HT7R. J Med Chem. 2018 08 23; 61(16):7218-7233. PMID: 30028132.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  45. Kim HJ, Jung SW, Kim SY, Cho IH, Kim HC, Rhim H, Kim M, Nah SY. Panax ginseng as an adjuvant treatment for Alzheimer's disease. J Ginseng Res. 2018 Oct; 42(4):401-411. PMID: 30337800; PMCID: PMC6190533.
    Citations: 39     
  46. Rahman MA, Kim H, Lee KH, Yun HM, Hong JH, Kim Y, Choo H, Park M, Rhim H. 5-Hydroxytryptamine 6 Receptor (5-HT6R)-Mediated Morphological Changes via RhoA-Dependent Pathways. Mol Cells. 2017 Jul 31; 40(7):495-502. PMID: 28681593; PMCID: PMC5547219.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  47. Yang YR, Song S, Hwang H, Jung JH, Kim SJ, Yoon S, Hur JH, Park JI, Lee C, Nam D, Seo YK, Kim JH, Rhim H, Suh PG. Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation. Sci Rep. 2017 04 03; 7:44921. PMID: 28368052; PMCID: PMC5377249.
    Citations: 11     Fields:    Translation:AnimalsCells
  48. Kim HJ, Park SD, Lee RM, Lee BH, Choi SH, Hwang SH, Rhim H, Kim HC, Nah SY. Gintonin attenuates depressive-like behaviors associated with alcohol withdrawal in mice. J Affect Disord. 2017 06; 215:23-29. PMID: 28314177.
    Citations: 13     Fields:    Translation:Animals
  49. Lee BH, Choi SH, Kim HJ, Park SD, Rhim H, Kim HC, Hwang SH, Nah SY. Gintonin absorption in intestinal model systems. J Ginseng Res. 2018 Jan; 42(1):35-41. PMID: 29348720; PMCID: PMC5766688.
    Citations: 6     
  50. Kim HJ, Kim DJ, Shin EJ, Lee BH, Choi SH, Hwang SH, Rhim H, Cho IH, Kim HC, Nah SY. Effects of gintonin-enriched fraction on hippocampal cell proliferation in wild-type mice and an APPswe/PSEN-1 double Tg mouse model of Alzheimer's disease. Neurochem Int. 2016 12; 101:56-65. PMID: 27765516.
    Citations: 19     Fields:    Translation:AnimalsCells
  51. Kim Y, Park H, Lee J, Tae J, Kim HJ, Min SJ, Rhim H, Choo H. 5-HT7 receptor modulators: Amino groups attached to biphenyl scaffold determine functional activity. Eur J Med Chem. 2016 Nov 10; 123:180-190. PMID: 27475109.
    Citations: 1     Fields:    Translation:HumansCells
  52. Lim BJ, Shin JI, Choi SE, Rhim H, Lee JS, Kim PK, Jeong HJ, Kim JH. The significance of tubulointerstitial lesions in childhood Henoch-Schönlein nephritis. Pediatr Nephrol. 2016 11; 31(11):2087-93. PMID: 27234910.
    Citations: 8     Fields:    Translation:Humans
  53. Lee BH, Choi SH, Kim HJ, Jung SW, Hwang SH, Pyo MK, Rhim H, Kim HC, Kim HK, Lee SM, Nah SY. Differential Effects of Quercetin and Quercetin Glycosides on Human a7 Nicotinic Acetylcholine Receptor-Mediated Ion Currents. Biomol Ther (Seoul). 2016 Jul 01; 24(4):410-7. PMID: 27098860; PMCID: PMC4930285.
    Citations: 3     
  54. Kim Y, Yeom M, Tae J, Rhim H, Choo H. Novel N-acyl-carbazole derivatives as 5-HT7R antagonists. Eur J Med Chem. 2016 Mar 03; 110:302-10. PMID: 26852005.
    Citations:    Fields:    Translation:HumansAnimalsCells
  55. Park M, Kim CH, Jo S, Kim EJ, Rhim H, Lee CJ, Kim JJ, Cho J. Chronic Stress Alters Spatial Representation and Bursting Patterns of Place Cells in Behaving Mice. Sci Rep. 2015 Nov 09; 5:16235. PMID: 26548337; PMCID: PMC4637823.
    Citations: 12     Fields:    Translation:AnimalsCells
  56. Kim D, Lim S, Haque MM, Ryoo N, Hong HS, Rhim H, Lee DE, Chang YT, Lee JS, Cheong E, Kim DJ, Kim YK. Identification of disulfide cross-linked tau dimer responsible for tau propagation. Sci Rep. 2015 Oct 15; 5:15231. PMID: 26470054; PMCID: PMC4606741.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  57. Yang Y, Kim J, Kim HY, Ryoo N, Lee S, Kim Y, Rhim H, Shin YK. Amyloid-ß Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a. Cell Rep. 2015 Aug 25; 12(8):1244-51. PMID: 26279571; PMCID: PMC4955600.
    Citations: 25     Fields:    Translation:AnimalsCells
  58. Kang B, Oh JA, Lee JY, Rhim H, Yune TY, Park Choo HY. 3-Benzamides and 3,4,5-trimethoxyphenyl amines as calcium channel blockers. Bioorg Med Chem. 2015 Sep 15; 23(18):6166-72. PMID: 26296911.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  59. Choi SH, Hong MK, Kim HJ, Ryoo N, Rhim H, Nah SY, Kang LW. Structure of ginseng major latex-like protein 151 and its proposed lysophosphatidic acid-binding mechanism. Acta Crystallogr D Biol Crystallogr. 2015 May; 71(Pt 5):1039-50. PMID: 25945569.
    Citations: 14     Fields:    Translation:AnimalsCells
  60. Huang M, Suk DH, Cho NC, Bhattarai D, Kang SB, Kim Y, Pae AN, Rhim H, Keum G. Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists. Bioorg Med Chem Lett. 2015 Apr 01; 25(7):1546-51. PMID: 25765911.
    Citations: 1     Fields:    Translation:HumansCells
  61. Choi SH, Lee BH, Kim HJ, Jung SW, Kim HS, Shin HC, Lee JH, Kim HC, Rhim H, Hwang SH, Ha TS, Kim HJ, Cho H, Nah SY. Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites. Mol Cells. 2014 Sep; 37(9):656-63. PMID: 25234465; PMCID: PMC4179134.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  62. Kim HJ, Kang S, Kim HJ, Choi SH, Shin S, Lee HH, Rhim H, Shin KH. Effect of acute and chronic electroconvulsive shock on 5-hydroxytrypamine 6 receptor immunoreactivity in rat hippocampus. Exp Neurobiol. 2014 Sep; 23(3):231-7. PMID: 25258570; PMCID: PMC4174614.
    Citations:    
  63. Kim Y, Tae J, Lee K, Rhim H, Choo IH, Cho H, Park WK, Keum G, Choo H. Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression. Bioorg Med Chem. 2014 Sep 01; 22(17):4587-96. PMID: 25127461.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  64. Jang SJ, Choi HW, Choi DL, Cho S, Rim HK, Choi HE, Kim KS, Huang M, Rhim H, Lee KT, Lee JY. In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. Bioorg Med Chem Lett. 2013 Dec 15; 23(24):6656-62. PMID: 24220170.
    Citations: 12     Fields:    Translation:HumansCells
  65. Kim J, Kim Y, Tae J, Yeom M, Moon B, Huang XP, Roth BL, Lee K, Rhim H, Choo IH, Chong Y, Keum G, Nam G, Choo H. Aryl biphenyl-3-ylmethylpiperazines as 5-HT7 receptor antagonists. ChemMedChem. 2013 Nov; 8(11):1855-64. PMID: 24039134.
    Citations:    Fields:    Translation:Cells
  66. Hayat F, Cho S, Rhim H, Indu Viswanath AN, Pae AN, Lee JY, Choo DJ, Choo HY. Design and synthesis of novel series of 5-HT6 receptor ligands having indole, a central aromatic core and 1-amino-4 methyl piperazine as a positive ionizable group. Bioorg Med Chem. 2013 Sep 01; 21(17):5573-82. PMID: 23810425.
    Citations:    Fields:    Translation:HumansCells
  67. Kim Y, Kim J, Tae J, Roth BL, Rhim H, Keum G, Nam G, Choo H. Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor. Bioorg Med Chem. 2013 May 01; 21(9):2568-76. PMID: 23541835.
    Citations: 1     Fields:    Translation:HumansCells
  68. Shin TJ, Kim HJ, Kwon BJ, Choi SH, Kim HB, Hwang SH, Lee BH, Lee SM, Zukin RS, Park JH, Kim HC, Rhim H, Lee JH, Nah SY. Gintonin, a ginseng-derived novel ingredient, evokes long-term potentiation through N-methyl-D-aspartic acid receptor activation: involvement of LPA receptors. Mol Cells. 2012 Dec; 34(6):563-72. PMID: 23161173; PMCID: PMC3887827.
    Citations: 21     Fields:    Translation:AnimalsCells
  69. Lee JW, Kang HS, Lee JY, Lee EJ, Rhim H, Yoon JH, Seo SR, Chung KC. The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7. Biochem Biophys Res Commun. 2012 Apr 06; 420(2):404-10. PMID: 22426484.
    Citations: 9     Fields:    Translation:HumansCells
  70. Lee S, Kim Y, Back SK, Choi HW, Lee JY, Jung HH, Ryu JH, Suh HW, Na HS, Kim HJ, Rhim H, Kim JI. Analgesic effect of highly reversible ?-conotoxin FVIA on N type Ca2+ channels. Mol Pain. 2010 Dec 21; 6:97. PMID: 21172037; PMCID: PMC3025903.
    Citations: 17     Fields:    Translation:Animals
  71. Lee BH, Choi SH, Shin TJ, Pyo MK, Hwang SH, Kim BR, Lee SM, Lee JH, Kim HC, Park HY, Rhim H, Nah SY. Quercetin enhances human a7 nicotinic acetylcholine receptor-mediated ion current through interactions with Ca(2+) binding sites. Mol Cells. 2010 Sep; 30(3):245-53. PMID: 20803082.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  72. Shin TJ, Choi SH, Lee BH, Pyo MK, Hwang SH, Kim BR, Lee SM, Han YS, Lee JH, Park JH, Kim HC, Rhim H, Nah SY. Effects of quercetin on human a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated ion currents. Biol Pharm Bull. 2010; 33(9):1615-9. PMID: 20823584.
    Citations:    Fields:    Translation:HumansAnimalsCells
  73. Lee KY, Shim S, Kim IS, Oh H, Kim S, Ahn JP, Park SH, Rhim H, Choi HJ. Coupling of semiconductor nanowires with neurons and their interfacial structure. Nanoscale Res Lett. 2009 Dec 04; 5(2):410-5. PMID: 20672083; PMCID: PMC2894234.
    Citations: 5     
  74. Choi SH, Lee JH, Pyo MK, Lee BH, Shin TJ, Hwang SH, Kim BR, Lee SM, Oh JW, Kim HC, Bae CS, Rhim H, Nah SY. Mutations Leu427, Asn428, and Leu431 residues within transmembrane domain-I-segment 6 attenuate ginsenoside-mediated L-type Ca(2+) channel current inhibitions. Biol Pharm Bull. 2009 Jul; 32(7):1224-30. PMID: 19571390.
    Citations: 12     Fields:    Translation:AnimalsCells
  75. Lee BH, Choi SH, Pyo MK, Shin TJ, Hwang SH, Kim BR, Lee SM, Lee JH, Lee JH, Lee HS, Choe H, Han KH, Kim HC, Rhim H, Yong JH, Nah SY. A role for Leu247 residue within transmembrane domain 2 in ginsenoside-mediated alpha7 nicotinic acetylcholine receptor regulation. Mol Cells. 2009 May 31; 27(5):591-9. PMID: 19466608.
    Citations: 3     Fields:    Translation:AnimalsCells
  76. Lee BH, Choi SH, Pyo MK, Shin TJ, Hwang SH, Kim BR, Lee JH, Rhim H, Kim HC, Nah SY. A role for the Val291 residue within the transmembrane domain 2 in diltiazem- and TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester]-mediated 5-hydroxytryptamine type 3A receptor regulations. Biol Pharm Bull. 2009 May; 32(5):861-7. PMID: 19420755.
    Citations: 1     Fields:    Translation:AnimalsCells
  77. Lee BH, Choi MJ, Jo MN, Seo HJ, Nah SY, Cho YS, Nam G, Pae AN, Rhim H, Choo H. Quinazolindione derivatives as potent 5-HT3A receptor antagonists. Bioorg Med Chem. 2009 Jul 01; 17(13):4793-6. PMID: 19447040.
    Citations: 3     Fields:    Translation:AnimalsCells
  78. Lee JH, Choi SH, Lee BH, Shin TJ, Pyo MK, Hwang SH, Kim BR, Lee SM, Bae DH, Rhim H, Nah SY. The effects of ginsenoside Rg(3) on human Kv1.4 channel currents without the N-terminal rapid inactivation domain. Biol Pharm Bull. 2009 Apr; 32(4):614-8. PMID: 19336893.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  79. Lee JY, Moon JS, Eu YJ, Lee CW, Yang ST, Lee SK, Jung HH, Kim HH, Rhim H, Seong JY, Kim JI. Molecular interaction between kisspeptin decapeptide analogs and a lipid membrane. Arch Biochem Biophys. 2009 May 15; 485(2):109-14. PMID: 19275876.
    Citations: 2     Fields:    Translation:AnimalsCells
  80. Heo JH, Seo HN, Choe YJ, Kim S, Oh CR, Kim YD, Rhim H, Choo DJ, Kim J, Lee JY. T-type Ca2+ channel blockers suppress the growth of human cancer cells. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):3899-901. PMID: 18585035.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  81. Oh DY, Yoon JM, Moon MJ, Hwang JI, Choe H, Lee JY, Kim JI, Kim S, Rhim H, O'Dell DK, Walker JM, Na HS, Lee MG, Kwon HB, Kim K, Seong JY. Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. J Biol Chem. 2008 Jul 25; 283(30):21054-64. PMID: 18499677; PMCID: PMC2475705.
    Citations: 58     Fields:    Translation:HumansCells
  82. Lee BH, Pyo MK, Lee JH, Choi SH, Shin TJ, Lee SM, Lim Y, Han YS, Paik HD, Cho SG, Yun-Choi HS, Rhim H, Nah SY. Differential regulations of quercetin and its glycosides on ligand-gated ion channels. Biol Pharm Bull. 2008 Apr; 31(4):611-7. PMID: 18379051.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  83. Lee JH, Choi SH, Lee BH, Yoon IS, Shin TJ, Pyo MK, Lee SM, Rhim H, Park MH, Park TY, Nah SY. Modifications of aliphatic side chain of 20(S)-ginsenoside RG3 cause an enhancement or loss of brain Na+ channel current inhibitions. Biol Pharm Bull. 2008 Mar; 31(3):480-6. PMID: 18310914.
    Citations: 3     Fields:    Translation:AnimalsCells
  84. Lee JH, Choi SH, Kwon OS, Shin TJ, Lee JH, Lee BH, Yoon IS, Pyo MK, Rhim H, Lim YH, Shim YH, Ahn JY, Kim HC, Chitwood DJ, Lee SM, Nah SY. Effects of ginsenosides, active ingredients of Panax ginseng, on development, growth, and life span of Caenorhabditis elegans. Biol Pharm Bull. 2007 Nov; 30(11):2126-34. PMID: 17978487.
    Citations: 17     Fields:    Translation:AnimalsCells
  85. Lee JH, Lee BH, Choi SH, Yoon IS, Pyo MK, Shin TJ, Choi WS, Lim Y, Rhim H, Won KH, Lim YW, Choe H, Kim DH, Kim YI, Nah SY. Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. Mol Pharmacol. 2008 Mar; 73(3):619-26. PMID: 17959711.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  86. Lee BH, Lee JH, Yoon IS, Lee JH, Choi SH, Shin TJ, Pyo MK, Choi WS, Lee SM, Lim Y, Rhim H, Nah SY. Mutations of arginine 222 in pre-transmembrane domain I of mouse 5-HT(3A) receptor abolish 20(R)- but not 20(S)-ginsenoside Rg(3) inhibition of 5-HT-mediated ion currents. Biol Pharm Bull. 2007 Sep; 30(9):1721-6. PMID: 17827728.
    Citations: 4     Fields:    Translation:AnimalsCells
  87. Lee BH, Lee JH, Yoon IS, Lee JH, Choi SH, Pyo MK, Jeong SM, Choi WS, Shin TJ, Lee SM, Rhim H, Park YS, Han YS, Paik HD, Cho SG, Kim CH, Lim YH, Nah SY. Human glycine alpha1 receptor inhibition by quercetin is abolished or inversed by alpha267 mutations in transmembrane domain 2. Brain Res. 2007 Aug 03; 1161:1-10. PMID: 17603028.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  88. Lee JH, Shin EJ, Jeong SM, Lee BH, Yoon IS, Lee JH, Choi SH, Kim YH, Pyo MK, Lee SM, Chae JS, Rhim H, Oh JW, Kim HC, Nah SY. Effects of dextrorotatory morphinans on brain Na+ channels expressed in Xenopus oocytes. Eur J Pharmacol. 2007 Jun 14; 564(1-3):7-17. PMID: 17346698.
    Citations: 1     Fields:    Translation:AnimalsCells
  89. Lee BH, Lee JH, Lee SM, Jeong SM, Yoon IS, Lee JH, Choi SH, Pyo MK, Rhim H, Kim HC, Jang CG, Lee BC, Park CS, Nah SY. Identification of ginsenoside interaction sites in 5-HT3A receptors. Neuropharmacology. 2007 Mar; 52(4):1139-50. PMID: 17257631.
    Citations: 8     Fields:    Translation:AnimalsCells
  90. Kim JH, Cho SY, Lee JH, Jeong SM, Yoon IS, Lee BH, Lee JH, Pyo MK, Lee SM, Chung JM, Kim S, Rhim H, Oh JW, Nah SY. Neuroprotective effects of ginsenoside Rg3 against homocysteine-induced excitotoxicity in rat hippocampus. Brain Res. 2007 Mar 09; 1136(1):190-9. PMID: 17239831.
    Citations: 25     Fields:    Translation:AnimalsCells
  91. Kim JH, Cho SY, Kang CW, Yoon IS, Lee JH, Jeong SM, Lee BH, Lee JH, Pyo MK, Choi SH, Quan SF, Lee JH, Choi CB, Rhim H, Nah SY. Ginseng saponins diminish adverse vascular effects associated with chronic methionine-induced hyperhomocysteinemia. Biol Pharm Bull. 2006 Dec; 29(12):2425-31. PMID: 17142976.
    Citations: 1     Fields:    Translation:Animals
  92. Park JH, Choi JK, Lee E, Lee JK, Rhim H, Seo SH, Kim Y, Doddareddy MR, Pae AN, Kang J, Roh EJ. Lead discovery and optimization of T-type calcium channel blockers. Bioorg Med Chem. 2007 Feb 01; 15(3):1409-19. PMID: 17150365.
    Citations: 3     Fields:    Translation:AnimalsCells
  93. Yoon IS, Jeong SM, Lee SN, Lee JH, Kim JH, Pyo MK, Lee JH, Lee BH, Choi SH, Rhim H, Choe H, Nah SY. Cloning and heterologous expression of a Ca2+-activated chloride channel isoform from rat brain. Biol Pharm Bull. 2006 Nov; 29(11):2168-73. PMID: 17077509.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  94. Doddareddy MR, Choo H, Cho YS, Rhim H, Koh HY, Lee JH, Jeong SW, Pae AN. 3D pharmacophore based virtual screening of T-type calcium channel blockers. Bioorg Med Chem. 2007 Jan 15; 15(2):1091-105. PMID: 17074493.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  95. Choi JY, Seo HN, Lee MJ, Park SJ, Park SJ, Jeon JY, Kang JH, Pae AN, Rhim H, Lee JY. Synthesis and biological evaluation of novel T-type calcium channel blockers. Bioorg Med Chem Lett. 2007 Jan 15; 17(2):471-5. PMID: 17064894.
    Citations: 7     Fields:    Translation:AnimalsCells
  96. Kim EJ, Sung JY, Lee HJ, Rhim H, Hasegawa M, Iwatsubo T, Min do S, Kim J, Paik SR, Chung KC. Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. J Biol Chem. 2006 Nov 03; 281(44):33250-7. PMID: 16959772.
    Citations: 42     Fields:    Translation:HumansCells
  97. Ku IW, Cho S, Doddareddy MR, Jang MS, Keum G, Lee JH, Chung BY, Kim Y, Rhim H, Kang SB. Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers. Bioorg Med Chem Lett. 2006 Oct 01; 16(19):5244-8. PMID: 16876404.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  98. Lee JY, Park SJ, Park SJ, Lee MJ, Rhim H, Seo SH, Kim KS. Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers. Bioorg Med Chem Lett. 2006 Oct 01; 16(19):5014-7. PMID: 16876410.
    Citations: 7     Fields:    Translation:HumansCells
  99. Lee E, Kim S, Chung KC, Choo MK, Kim DH, Nam G, Rhim H. 20(S)-ginsenoside Rh2, a newly identified active ingredient of ginseng, inhibits NMDA receptors in cultured rat hippocampal neurons. Eur J Pharmacol. 2006 Apr 24; 536(1-2):69-77. PMID: 16563373.
    Citations: 25     Fields:    Translation:AnimalsCells
  100. Park SJ, Park SJ, Lee MJ, Rhim H, Kim Y, Lee JH, Chung BY, Lee JY. Synthesis and SAR studies of a novel series of T-type calcium channel blockers. Bioorg Med Chem. 2006 May 15; 14(10):3502-11. PMID: 16434203.
    Citations: 6     Fields:    Translation:HumansCells
  101. Um JW, Min DS, Rhim H, Kim J, Paik SR, Chung KC. Parkin ubiquitinates and promotes the degradation of RanBP2. J Biol Chem. 2006 Feb 10; 281(6):3595-603. PMID: 16332688.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  102. Lee JH, Jeong SM, Kim JH, Lee BH, Yoon IS, Lee JH, Choi SH, Kim DH, Rhim H, Kim SS, Kim JI, Jang CG, Song JH, Nah SY. Characteristics of ginsenoside Rg3-mediated brain Na+ current inhibition. Mol Pharmacol. 2005 Oct; 68(4):1114-26. PMID: 16014805.
    Citations: 13     Fields:    Translation:Animals
  103. Kim JH, Kim S, Yoon IS, Lee JH, Jang BJ, Jeong SM, Lee JH, Lee BH, Han JS, Oh S, Kim HC, Park TK, Rhim H, Nah SY. Protective effects of ginseng saponins on 3-nitropropionic acid-induced striatal degeneration in rats. Neuropharmacology. 2005 Apr; 48(5):743-56. PMID: 15814108.
    Citations: 19     Fields:    Translation:Animals
  104. Jeong SM, Lee JH, Kim JH, Lee BH, Yoon IS, Lee JH, Kim DH, Rhim H, Kim Y, Nah SY. Stereospecificity of ginsenoside Rg3 action on ion channels. Mol Cells. 2004 Dec 31; 18(3):383-9. PMID: 15650337.
    Citations: 18     Fields:    Translation:AnimalsCells
  105. Lee YS, Lee BH, Park SJ, Kang SB, Rhim H, Park JY, Lee JH, Jeong SW, Lee JY. 3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers. Bioorg Med Chem Lett. 2004 Jul 05; 14(13):3379-84. PMID: 15177437.
    Citations: 7     Fields:    Translation:AnimalsCells
  106. Jeong SM, Lee JH, Kim S, Rhim H, Lee BH, Kim JH, Oh JW, Lee SM, Nah SY. Ginseng saponins induce store-operated calcium entry in Xenopus oocytes. Br J Pharmacol. 2004 Jun; 142(3):585-93. PMID: 15148256; PMCID: PMC1574966.
    Citations: 6     Fields:    Translation:AnimalsCells
  107. Lee JH, Jeong SM, Lee BH, Noh HS, Kim BK, Kim JI, Rhim H, Kim HC, Kim KM, Nah SY. Prevention of ginsenoside-induced desensitization of Ca2+-activated Cl- current by microinjection of inositol hexakisphosphate in Xenopus laevis oocytes: involvement of GRK2 and beta-arrestin I. J Biol Chem. 2004 Mar 12; 279(11):9912-21. PMID: 14699097.
    Citations: 11     Fields:    Translation:AnimalsCells
  108. Choi S, Lee JH, Oh S, Rhim H, Lee SM, Nah SY. Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. Mol Cells. 2003 Feb 28; 15(1):108-13. PMID: 12661769.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  109. Yune TY, Chang MJ, Kim SJ, Lee YB, Shin SW, Rhim H, Kim YC, Shin ML, Oh YJ, Han CT, Markelonis GJ, Oh TH. Increased production of tumor necrosis factor-alpha induces apoptosis after traumatic spinal cord injury in rats. J Neurotrauma. 2003 Feb; 20(2):207-19. PMID: 12675973.
    Citations: 34     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.