Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Peter D. Caravan, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R33HL154125 (CARAVAN, PETER D) Aug 15, 2020 - Jul 31, 2022
    Optimization of PET probe for imaging lung fibrogenesis
    Role: Principal Investigator
  2. R01DK121789 (CARAVAN, PETER D) Jul 3, 2019 - May 31, 2023
    Molecular MR Imaging of Hepatic Fibrogenesis
    Role: Principal Investigator
  3. R13EB028131 (CARAVAN, PETER D) Apr 1, 2019 - Mar 31, 2020
    The Future of Molecular MR: A Cellular and Molecular MR Imaging Workshop
    Role: Principal Investigator
  4. S10OD025234 (CARAVAN, PETER D) Mar 15, 2018 - Mar 14, 2019
    Electronics Upgrade for 11.7 T
    Role: Principal Investigator
  5. S10OD023503 (CARAVAN, PETER D) Apr 15, 2017 - Apr 14, 2019
    MRI-Compatible PET Insert for Small Bore Scanner
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dos Santos Ferreira D, Arora G, Gieseck RL, Rotile NJ, Waghorn PA, Tanabe KK, Wynn TA, Caravan P, Fuchs BC. Molecular Magnetic Resonance Imaging of Liver Fibrosis and Fibrogenesis Is Not Altered by Inflammation. Invest Radiol. 2021 Apr 01; 56(4):244-251. PMID: 33109919.
    Citations: 1     Fields:    
  2. Zhou IY, Ramsay IA, Ay I, Pantazopoulos P, Rotile NJ, Wong A, Caravan P, Gale EM. Positron Emission Tomography-Magnetic Resonance Imaging Pharmacokinetics, In Vivo Biodistribution, and Whole-Body Elimination of Mn-PyC3A. Invest Radiol. 2021 Apr 01; 56(4):261-270. PMID: 33136686.
    Citations:    Fields:    
  3. Zhang C, O'Shea A, Parente CA, Amorim BJ, Caravan P, Ferrone CR, Blaszkowsky LS, Soricelli A, Salvatore M, Groshar D, Bernstine H, Domachevsky L, Canamaque LG, Umutlu L, Ken H, Catana C, Mahmood U, Catalano OA. Evaluation of the Diagnostic Performance of Positron Emission Tomography/Magnetic Resonance for the Diagnosis of Liver Metastases. Invest Radiol. 2021 Mar 25. PMID: 33813576.
    Citations:    Fields:    
  4. Waghorn PA, Ferreira DS, Erstad DJ, Rotile NJ, Masia R, Jones CM, Tu C, Sojoodi M, Chen YI, Schlerman F, Wellen J, Martinez RVP, Tanabe KK, Fuchs BC, Caravan P. Quantitative, noninvasive MRI characterization of disease progression in a mouse model of non-alcoholic steatohepatitis. Sci Rep. 2021 Mar 17; 11(1):6105. PMID: 33731798.
    Citations:    Fields:    
  5. Le Fur M, Caravan P. 86Y PET imaging. Methods Enzymol. 2021; 651:313-342. PMID: 33888208.
    Citations:    Fields:    
  6. Shuvaev S, Akam E, Caravan P. Molecular MR Contrast Agents. Invest Radiol. 2021 Jan; 56(1):20-34. PMID: 33074931.
    Citations: 2     Fields:    
  7. Wang H, Wong A, Lewis LC, Nemeth GR, Jordan VC, Bacon JW, Caravan P, Shafaat HS, Gale EM. Rational Ligand Design Enables pH Control over Aqueous Iron Magnetostructural Dynamics and Relaxometric Properties. Inorg Chem. 2020 Dec 07; 59(23):17712-17721. PMID: 33216537.
    Citations:    Fields:    
  8. Nahrendorf M, Hoyer FF, Meerwaldt AE, van Leent MMT, Senders ML, Calcagno C, Robson PM, Soultanidis G, Pérez-Medina C, Teunissen AJP, Toner YC, Ishikawa K, Fish K, Sakurai K, van Leeuwen EM, Klein ED, Sofias AM, Reiner T, Rohde D, Aguirre AD, Wojtkiewicz G, Schmidt S, Iwamoto Y, Izquierdo-Garcia D, Caravan P, Swirski FK, Weissleder R, Mulder WJM. Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor 64Cu-Macrin in Mice, Rabbits, and Pigs. Circ Cardiovasc Imaging. 2020 10; 13(10):e010586. PMID: 33076700.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Shuvaev S, Suturina EA, Rotile NJ, Astashkin A, Ziegler CJ, Ross AW, Walker TL, Caravan P, Taschner IS. Revisiting dithiadiaza macrocyclic chelators for copper-64 PET imaging. Dalton Trans. 2020 Oct 20; 49(40):14088-14098. PMID: 32970072.
    Citations:    Fields:    
  10. King RM, Caroff J, Langan ET, Leporati A, Rodriguez-Rodriguez A, Raskett CM, Gupta S, Puri AS, Caravan P, Gounis MJ, Bogdanov AA. In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling. J Neurointerv Surg. 2021 Mar; 13(3):267-271. PMID: 33020207.
    Citations:    Fields:    Translation:Animals
  11. Le Fur M, Zhou IY, Catalano O, Caravan P. Toward Molecular Imaging of Intestinal Pathology. Inflamm Bowel Dis. 2020 09 18; 26(10):1470-1484. PMID: 32793946.
    Citations: 2     Fields:    
  12. Zhou IY, Tanabe KK, Fuchs BC, Caravan P. Collagen-targeted molecular imaging in diffuse liver diseases. Abdom Radiol (NY). 2020 11; 45(11):3545-3556. PMID: 32737546.
    Citations: 1     Fields:    
  13. Erstad DJ, Sojoodi M, Taylor MS, Jordan VC, Farrar CT, Axtell AL, Rotile NJ, Jones C, Graham-O'Regan KA, Ferreira DS, Michelakos T, Kontos F, Chawla A, Li S, Ghoshal S, Chen YI, Arora G, Humblet V, Deshpande V, Qadan M, Bardeesy N, Ferrone CR, Lanuti M, Tanabe KK, Caravan P, Fuchs BC. Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI. Clin Cancer Res. 2020 09 15; 26(18):5007-5018. PMID: 32611647.
    Citations: 3     Fields:    
  14. Zhou IY, Catalano OA, Caravan P. Advances in functional and molecular MRI technologies in chronic liver diseases. J Hepatol. 2020 11; 73(5):1241-1254. PMID: 32585160.
    Citations: 3     Fields:    
  15. Gupta A, Caravan P, Price WS, Platas-Iglesias C, Gale EM. Applications for Transition-Metal Chemistry in Contrast-Enhanced Magnetic Resonance Imaging. Inorg Chem. 2020 May 18; 59(10):6648-6678. PMID: 32367714.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Zhou IY, Clavijo Jordan V, Rotile NJ, Akam E, Krishnan S, Arora G, Krishnan H, Slattery H, Warner N, Mercaldo N, Farrar CT, Wellen J, Martinez R, Schlerman F, Tanabe KK, Fuchs BC, Caravan P. Advanced MRI of Liver Fibrosis and Treatment Response in a Rat Model of Nonalcoholic Steatohepatitis. Radiology. 2020 07; 296(1):67-75. PMID: 32343209.
    Citations: 4     Fields:    Translation:Animals
  17. Atanasova I, Sojoodi M, Leitão HS, Shuvaev S, Geraldes CFGC, Masia R, Guimaraes AS, Tanabe KK, Fuchs BC, Caravan P. Molecular Magnetic Resonance Imaging of Fibrin Deposition in the Liver as an Indicator of Tissue Injury and Inflammation. Invest Radiol. 2020 04; 55(4):209-216. PMID: 31895219.
    Citations: 1     Fields:    Translation:Animals
  18. Frenk NE, Montesi SB, Chen T, Liang LL, Zhou I, Seethamraju R, Caravan P, Digumarthy SR. Free-breathing dynamic contrast-enhanced magnetic resonance of interstitial lung fibrosis. Magn Reson Imaging. 2020 06; 69:16-21. PMID: 32126265.
    Citations: 2     Fields:    Translation:Humans
  19. Gholami YH, Josephson L, Akam EA, Caravan P, Wilks MQ, Pan XZ, Maschmeyer R, Kolnick A, El Fakhri G, Normandin MD, Kuncic Z, Yuan H. A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes. Int J Nanomedicine. 2020; 15:31-47. PMID: 32021163.
    Citations: 2     Fields:    
  20. Le Fur M, Rotile NJ, Correcher C, Clavijo Jordan V, Ross AW, Catana C, Caravan P. Yttrium-86 Is a Positron Emitting Surrogate of Gadolinium for Noninvasive Quantification of Whole-Body Distribution of Gadolinium-Based Contrast Agents. Angew Chem Int Ed Engl. 2020 01 20; 59(4):1474-1478. PMID: 31750991.
    Citations: 3     Fields:    Translation:Humans
  21. Akam EA, Abston E, Rotile NJ, Slattery HR, Zhou IY, Lanuti M, Caravan P. Improving the reactivity of hydrazine-bearing MRI probes for in vivo imaging of lung fibrogenesis. Chem Sci. 2020 Jan 07; 11(1):224-231. PMID: 32728411.
    Citations: 4     
  22. Erstad DJ, Ramsay IA, Jordan VC, Sojoodi M, Fuchs BC, Tanabe KK, Caravan P, Gale EM. Tumor Contrast Enhancement and Whole-Body Elimination of the Manganese-Based Magnetic Resonance Imaging Contrast Agent Mn-PyC3A. Invest Radiol. 2019 11; 54(11):697-703. PMID: 31356382.
    Citations: 3     Fields:    Translation:Animals
  23. Rodríguez-Rodríguez A, Shuvaev S, Rotile N, Jones CM, Probst CK, Dos Santos Ferreira D, Graham-O Regan K, Boros E, Knipe RS, Griffith JW, Tager AM, Bogdanov A, Caravan P. Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation. ACS Sens. 2019 09 27; 4(9):2412-2419. PMID: 31397156.
    Citations: 3     Fields:    Translation:Animals
  24. Montesi SB, Izquierdo-Garcia D, Désogère P, Abston E, Liang LL, Digumarthy S, Seethamraju R, Lanuti M, Caravan P, Catana C. Type I Collagen-targeted Positron Emission Tomography Imaging in Idiopathic Pulmonary Fibrosis: First-in-Human Studies. Am J Respir Crit Care Med. 2019 07 15; 200(2):258-261. PMID: 31161770.
    Citations: 9     Fields:    Translation:Humans
  25. Caravan P, Esteban-Gómez D, Rodríguez-Rodríguez A, Platas-Iglesias C. Water exchange in lanthanide complexes for MRI applications. Lessons learned over the last 25 years. Dalton Trans. 2019 Aug 14; 48(30):11161-11180. PMID: 31241112.
    Citations: 4     Fields:    
  26. Montesi SB, Caravan P. Novel Imaging Approaches in Systemic Sclerosis-Associated Interstitial Lung Disease. Curr Rheumatol Rep. 2019 04 25; 21(6):25. PMID: 31025121.
    Citations: 4     Fields:    Translation:Humans
  27. Wang H, Jordan VC, Ramsay IA, Sojoodi M, Fuchs BC, Tanabe KK, Caravan P, Gale EM. Molecular Magnetic Resonance Imaging Using a Redox-Active Iron Complex. J Am Chem Soc. 2019 04 10; 141(14):5916-5925. PMID: 30874437.
    Citations: 15     Fields:    Translation:AnimalsCells
  28. Wahsner J, Désogère P, Abston E, Graham-O'Regan KA, Wang J, Rotile NJ, Schirmer MD, Santos Ferreira DD, Sui J, Fuchs BC, Lanuti M, Caravan P. 68Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis. J Am Chem Soc. 2019 04 10; 141(14):5593-5596. PMID: 30908032.
    Citations: 3     Fields:    Translation:Animals
  29. Li S, Ghoshal S, Sojoodi M, Arora G, Masia R, Erstad DJ, Ferriera DS, Li Y, Wang G, Lanuti M, Caravan P, Or YS, Jiang LJ, Tanabe KK, Fuchs BC. The farnesoid X receptor agonist EDP-305 reduces interstitial renal fibrosis in a mouse model of unilateral ureteral obstruction. FASEB J. 2019 06; 33(6):7103-7112. PMID: 30884252.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  30. Le Fur M, Caravan P. The biological fate of gadolinium-based MRI contrast agents: a call to action for bioinorganic chemists. Metallomics. 2019 02 20; 11(2):240-254. PMID: 30516229.
    Citations: 13     Fields:    Translation:Cells
  31. Montesi SB, Désogère P, Fuchs BC, Caravan P. Molecular imaging of fibrosis: recent advances and future directions. J Clin Invest. 2019 01 02; 129(1):24-33. PMID: 30601139.
    Citations: 24     Fields:    Translation:HumansAnimals
  32. Désogère P, Montesi SB, Caravan P. Molecular Probes for Imaging Fibrosis and Fibrogenesis. Chemistry. 2019 Jan 24; 25(5):1128-1141. PMID: 30014529.
    Citations: 12     Fields:    Translation:HumansAnimals
  33. Murphy AP, Greally E, O'Hogain D, Blamire A, Caravan P, Straub V. Noninvasive quantification of fibrosis in skeletal and cardiac muscle in mdx mice using EP3533 enhanced magnetic resonance imaging. Magn Reson Med. 2019 04; 81(4):2728-2735. PMID: 30394578.
    Citations: 2     Fields:    Translation:Animals
  34. Caravan P, Luchinat C, Sherry AD. In Memoriam: Seymour H. Koenig (1927-2018). Magn Reson Med. 2019 02; 81(2):743-745. PMID: 30346048.
    Citations:    Fields:    
  35. Wahsner J, Gale EM, Rodríguez-Rodríguez A, Caravan P. Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers. Chem Rev. 2019 01 23; 119(2):957-1057. PMID: 30350585.
    Citations: 69     Fields:    Translation:Humans
  36. Wang J, Wang H, Ramsay IA, Erstad DJ, Fuchs BC, Tanabe KK, Caravan P, Gale EM. Manganese-Based Contrast Agents for Magnetic Resonance Imaging of Liver Tumors: Structure-Activity Relationships and Lead Candidate Evaluation. J Med Chem. 2018 10 11; 61(19):8811-8824. PMID: 30204438.
    Citations: 7     Fields:    Translation:HumansAnimals
  37. Vandoorne K, Rohde D, Kim HY, Courties G, Wojtkiewicz G, Honold L, Hoyer FF, Frodermann V, Nayar R, Herisson F, Jung Y, Désogère PA, Vinegoni C, Caravan P, Weissleder R, Sosnovik DE, Lin CP, Swirski FK, Nahrendorf M. Imaging the Vascular Bone Marrow Niche During Inflammatory Stress. Circ Res. 2018 08 03; 123(4):415-427. PMID: 29980569.
    Citations: 10     Fields:    Translation:AnimalsCells
  38. Erstad DJ, Sojoodi M, Taylor MS, Ghoshal S, Razavi AA, Graham-O'Regan KA, Bardeesy N, Ferrone CR, Lanuti M, Caravan P, Tanabe KK, Fuchs BC. Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy. Dis Model Mech. 2018 07 30; 11(7). PMID: 29903803.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  39. Erstad DJ, Farrar CT, Ghoshal S, Masia R, Ferreira DS, Chen YI, Choi JK, Wei L, Waghorn PA, Rotile NJ, Tu C, Graham-O'Regan KA, Sojoodi M, Li S, Li Y, Wang G, Corey KE, Or YS, Jiang L, Tanabe KK, Caravan P, Fuchs BC. Molecular magnetic resonance imaging accurately measures the antifibrotic effect of EDP-305, a novel farnesoid X receptor agonist. Hepatol Commun. 2018 Jul; 2(7):821-835. PMID: 30027140.
    Citations: 12     
  40. Montesi SB, Rao R, Liang LL, Goulart HE, Sharma A, Sharma A, Digumarthy SR, Shea BS, Seethamraju RT, Caravan P, Tager AM. Gadofosveset-enhanced lung magnetic resonance imaging to detect ongoing vascular leak in pulmonary fibrosis. Eur Respir J. 2018 05; 51(5). PMID: 29622569.
    Citations: 6     Fields:    Translation:Humans
  41. Wadghiri YZ, Hoang DM, Leporati A, Gounis MJ, Rodríguez-Rodríguez A, Mazzanti ML, Weaver JP, Wakhloo AK, Caravan P, Bogdanov AA. High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease. Sci Rep. 2018 05 16; 8(1):7687. PMID: 29769642.
    Citations: 4     Fields:    Translation:Humans
  42. Kruger AJ, Fuchs BC, Masia R, Holmes JA, Salloum S, Sojoodi M, Ferreira DS, Rutledge SM, Caravan P, Alatrakchi N, Vig P, Lefebvre E, Chung RT. Prolonged cenicriviroc therapy reduces hepatic fibrosis despite steatohepatitis in a diet-induced mouse model of nonalcoholic steatohepatitis. Hepatol Commun. 2018 May; 2(5):529-545. PMID: 29761169.
    Citations: 14     
  43. Dai L, Jones CM, Chan WTK, Pham TA, Ling X, Gale EM, Rotile NJ, Tai WC, Anderson CJ, Caravan P, Law GL. Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications. Nat Commun. 2018 02 27; 9(1):857. PMID: 29487362.
    Citations: 6     Fields:    Translation:Animals
  44. Wenande E, Tam J, Bhayana B, Schlosser SK, Ishak E, Farinelli WA, Chlopik A, Hoang MP, Pinkhasov OR, Caravan P, Rox Anderson R, Haedersdal M. Laser-assisted delivery of synergistic combination chemotherapy in in vivo skin. J Control Release. 2018 04 10; 275:242-253. PMID: 29454062.
    Citations: 3     Fields:    Translation:Animals
  45. Gale EM, Caravan P. Gadolinium-Free Contrast Agents for Magnetic Resonance Imaging of the Central Nervous System. ACS Chem Neurosci. 2018 03 21; 9(3):395-397. PMID: 29431424.
    Citations: 3     Fields:    Translation:Humans
  46. Boros E, Pinkhasov OR, Caravan P. Metabolite profiling with HPLC-ICP-MS as a tool for in vivo characterization of imaging probes. EJNMMI Radiopharm Chem. 2018; 3(1):2. PMID: 29503859.
  47. Farrar CT, Gale EM, Kennan R, Ramsay I, Masia R, Arora G, Looby K, Wei L, Kalpathy-Cramer J, Bunzel MM, Zhang C, Zhu Y, Akiyama TE, Klimas M, Pinto S, Diyabalanage H, Tanabe KK, Humblet V, Fuchs BC, Caravan P. CM-101: Type I Collagen-targeted MR Imaging Probe for Detection of Liver Fibrosis. Radiology. 2018 05; 287(2):581-589. PMID: 29156148.
    Citations: 16     Fields:    Translation:Animals
  48. Gale EM, Wey HY, Ramsay I, Yen YF, Sosnovik DE, Caravan P. A Manganese-based Alternative to Gadolinium: Contrast-enhanced MR Angiography, Excretion, Pharmacokinetics, and Metabolism. Radiology. 2018 03; 286(3):865-872. PMID: 29117483.
    Citations: 15     Fields:    Translation:Animals
  49. Oliveira BL, Caravan P. Peptide-based fibrin-targeting probes for thrombus imaging. Dalton Trans. 2017 Oct 31; 46(42):14488-14508. PMID: 29051933.
    Citations: 3     Fields:    Translation:HumansAnimals
  50. Waghorn PA, Oliveira BL, Jones CM, Tager AM, Caravan P. High sensitivity HPLC method for determination of the allysine concentration in tissue by use of a naphthol derivative. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Oct 01; 1064:7-13. PMID: 28886479.
    Citations: 3     Fields:    Translation:AnimalsCells
  51. Polasek M, Yang Y, Schühle DT, Yaseen MA, Kim YR, Sung YS, Guimaraes AR, Caravan P. Molecular MR imaging of fibrosis in a mouse model of pancreatic cancer. Sci Rep. 2017 08 14; 7(1):8114. PMID: 28808290.
    Citations: 9     Fields:    Translation:AnimalsCells
  52. Shen S, Lim G, You Z, Ding W, Huang P, Ran C, Doheny J, Caravan P, Tate S, Hu K, Kim H, McCabe M, Huang B, Xie Z, Kwon D, Chen L, Mao J. Gut microbiota is critical for the induction of chemotherapy-induced pain. Nat Neurosci. 2017 Sep; 20(9):1213-1216. PMID: 28714953.
    Citations: 43     Fields:    Translation:AnimalsCells
  53. Waghorn PA, Jones CM, Rotile NJ, Koerner SK, Ferreira DS, Chen HH, Probst CK, Tager AM, Caravan P. Molecular Magnetic Resonance Imaging of Lung Fibrogenesis with an Oxyamine-Based Probe. Angew Chem Int Ed Engl. 2017 08 07; 56(33):9825-9828. PMID: 28677860.
    Citations: 12     Fields:    Translation:AnimalsCells
  54. Désogère P, Tapias LF, Rietz TA, Rotile N, Blasi F, Day H, Elliott J, Fuchs BC, Lanuti M, Caravan P. Optimization of a Collagen-Targeted PET Probe for Molecular Imaging of Pulmonary Fibrosis. J Nucl Med. 2017 12; 58(12):1991-1996. PMID: 28611243.
    Citations: 7     Fields:    Translation:Animals
  55. Chen HH, Waghorn PA, Wei L, Tapias LF, Schühle DT, Rotile NJ, Jones CM, Looby RJ, Zhao G, Elliott JM, Probst CK, Mino-Kenudson M, Lauwers GY, Tager AM, Tanabe KK, Lanuti M, Fuchs BC, Caravan P. Molecular imaging of oxidized collagen quantifies pulmonary and hepatic fibrogenesis. JCI Insight. 2017 Jun 02; 2(11). PMID: 28570270.
    Citations: 16     Fields:    
  56. Shea BS, Probst CK, Brazee PL, Rotile NJ, Blasi F, Weinreb PH, Black KE, Sosnovik DE, Van Cott EM, Violette SM, Caravan P, Tager AM. Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis. JCI Insight. 2017 May 04; 2(9). PMID: 28469072.
    Citations: 15     Fields:    
  57. Gale EM, Caravan P, Rao AG, McDonald RJ, Winfeld M, Fleck RJ, Gee MS. Gadolinium-based contrast agents in pediatric magnetic resonance imaging. Pediatr Radiol. 2017 May; 47(5):507-521. PMID: 28409250.
    Citations: 15     Fields:    Translation:Humans
  58. Boros E, Srinivas R, Kim HK, Raitsimring AM, Astashkin AV, Poluektov OG, Niklas J, Horning AD, Tidor B, Caravan P. Intramolecular Hydrogen Bonding Restricts Gd-Aqua-Ligand Dynamics. Angew Chem Int Ed Engl. 2017 05 08; 56(20):5603-5606. PMID: 28398613.
    Citations: 3     Fields:    Translation:Cells
  59. Désogère P, Tapias LF, Hariri LP, Rotile NJ, Rietz TA, Probst CK, Blasi F, Day H, Mino-Kenudson M, Weinreb P, Violette SM, Fuchs BC, Tager AM, Lanuti M, Caravan P. Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models. Sci Transl Med. 2017 04 05; 9(384). PMID: 28381537.
    Citations: 31     Fields:    Translation:HumansAnimals
  60. Dos Santos Ferreira D, Jesus de Oliveira Pinto BL, Kumar V, Cardoso VN, Fernandes SO, Souza CM, Cassali GD, Moore A, Sosnovik DE, Farrar CT, Leite EA, Alves RJ, de Oliveira MC, Guimarães AR, Caravan P. Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice. Nanomedicine. 2017 07; 13(5):1693-1701. PMID: 28343016.
    Citations: 3     Fields:    Translation:Animals
  61. Zhu B, Wei L, Rotile N, Day H, Rietz T, Farrar CT, Lauwers GY, Tanabe KK, Rosen B, Fuchs BC, Caravan P. Combined magnetic resonance elastography and collagen molecular magnetic resonance imaging accurately stage liver fibrosis in a rat model. Hepatology. 2017 03; 65(3):1015-1025. PMID: 28039886.
    Citations: 17     Fields:    Translation:Animals
  62. Gale EM, Jones CM, Ramsay I, Farrar CT, Caravan P. A Janus Chelator Enables Biochemically Responsive MRI Contrast with Exceptional Dynamic Range. J Am Chem Soc. 2016 12 14; 138(49):15861-15864. PMID: 27960350.
    Citations: 11     Fields:    Translation:HumansCells
  63. Ferreira Ddos S, Faria SD, Lopes SC, Teixeira CS, Malachias A, Magalhães-Paniago R, de Souza Filho JD, Oliveira BL, Guimarães AR, Caravan P, Ferreira LA, Alves RJ, Oliveira MC. Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity, and biodistribution evaluation in a mouse model of bone metastasis. Int J Nanomedicine. 2016; 11:3737-51. PMID: 27563241.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  64. Guimaraes AR, Siqueira L, Uppal R, Alford J, Fuchs BC, Yamada S, Tanabe K, Chung RT, Lauwers G, Chew ML, Boland GW, Sahani DV, Vangel M, Hahn PF, Caravan P. T2 relaxation time is related to liver fibrosis severity. Quant Imaging Med Surg. 2016 Apr; 6(2):103-14. PMID: 27190762.
    Citations: 14     
  65. Iki N, Boros E, Nakamura M, Baba R, Caravan P. Gd3TCAS2: An Aquated Gd(3+)-Thiacalix[4]arene Sandwich Cluster with Extremely Slow Ligand Substitution Kinetics. Inorg Chem. 2016 Apr 18; 55(8):4000-5. PMID: 27018719.
    Citations: 1     Fields:    Translation:HumansCells
  66. Boros E, Holland JP, Kenton N, Rotile N, Caravan P. Macrocycle-Based Hydroxamate Ligands for Complexation and Immunoconjugation of 89Zirconium for Positron Emission Tomography (PET) Imaging. Chempluschem. 2016 Mar; 81(3):274-281. PMID: 27630807.
    Citations: 16     
  67. Meimetis LG, Boros E, Carlson JC, Ran C, Caravan P, Weissleder R. Bioorthogonal Fluorophore Linked DFO-Technology Enabling Facile Chelator Quantification and Multimodal Imaging of Antibodies. Bioconjug Chem. 2016 Jan 20; 27(1):257-63. PMID: 26684717.
    Citations: 10     Fields:    Translation:HumansAnimals
  68. Gale EM, Atanasova IP, Blasi F, Ay I, Caravan P. A Manganese Alternative to Gadolinium for MRI Contrast. J Am Chem Soc. 2015 Dec 16; 137(49):15548-57. PMID: 26588204.
    Citations: 38     Fields:    Translation:Cells
  69. Blasi F, Oliveira BL, Rietz TA, Rotile NJ, Naha PC, Cormode DP, Izquierdo-Garcia D, Catana C, Caravan P. Multisite Thrombus Imaging and Fibrin Content Estimation With a Single Whole-Body PET Scan in Rats. Arterioscler Thromb Vasc Biol. 2015 Oct; 35(10):2114-21. PMID: 26272938.
    Citations: 15     Fields:    Translation:Animals
  70. Oliveira BL, Blasi F, Rietz TA, Rotile NJ, Day H, Caravan P. Multimodal Molecular Imaging Reveals High Target Uptake and Specificity of 111In- and 68Ga-Labeled Fibrin-Binding Probes for Thrombus Detection in Rats. J Nucl Med. 2015 Oct; 56(10):1587-92. PMID: 26251420.
    Citations: 7     Fields:    Translation:Animals
  71. Farrar CT, DePeralta DK, Day H, Rietz TA, Wei L, Lauwers GY, Keil B, Subramaniam A, Sinskey AJ, Tanabe KK, Fuchs BC, Caravan P. 3D molecular MR imaging of liver fibrosis and response to rapamycin therapy in a bile duct ligation rat model. J Hepatol. 2015 Sep; 63(3):689-96. PMID: 26022693.
    Citations: 22     Fields:    Translation:Animals
  72. Blasi F, Oliveira BL, Rietz TA, Rotile NJ, Day H, Naha PC, Cormode DP, Izquierdo-Garcia D, Catana C, Caravan P. Radiation Dosimetry of the Fibrin-Binding Probe 64Cu-FBP8 and Its Feasibility for PET Imaging of Deep Vein Thrombosis and Pulmonary Embolism in Rats. J Nucl Med. 2015 Jul; 56(7):1088-93. PMID: 25977464.
    Citations: 9     Fields:    Translation:Animals
  73. Boros E, Gale EM, Caravan P. MR imaging probes: design and applications. Dalton Trans. 2015 Mar 21; 44(11):4804-4818. PMID: 25376893.
    Citations: 27     Fields:    Translation:HumansAnimals
  74. Boros E, Caravan P. Probing the structure-relaxivity relationship of bis-hydrated Gd(DOTAla) derivatives. Inorg Chem. 2015 Mar 02; 54(5):2403-10. PMID: 25693053.
    Citations: 3     Fields:    Translation:Cells
  75. Motola DL, Caravan P, Chung RT, Fuchs BC. Noninvasive Biomarkers of Liver Fibrosis: Clinical Applications and Future Directions. Curr Pathobiol Rep. 2014 Dec 01; 2(4):245-256. PMID: 25396099.
    Citations: 14     
  76. Gale EM, Mukherjee S, Liu C, Loving GS, Caravan P. Structure-redox-relaxivity relationships for redox responsive manganese-based magnetic resonance imaging probes. Inorg Chem. 2014 Oct 06; 53(19):10748-61. PMID: 25226090.
    Citations: 12     Fields:    Translation:Cells
  77. Zhu J, Gale EM, Atanasova I, Rietz TA, Caravan P. Hexameric Mn(II) dendrimer as MRI contrast agent. Chemistry. 2014 Oct 27; 20(44):14507-13. PMID: 25224391.
    Citations: 8     Fields:    Translation:Animals
  78. Boros E, Karimi S, Kenton N, Helm L, Caravan P. Gd(DOTAlaP): exploring the boundaries of fast water exchange in gadolinium-based magnetic resonance imaging contrast agents. Inorg Chem. 2014 Jul 07; 53(13):6985-94. PMID: 24922178.
    Citations: 7     Fields:    Translation:AnimalsCells
  79. Blasi F, Oliveira BL, Rietz TA, Rotile NJ, Day H, Looby RJ, Ay I, Caravan P. Effect of Chelate Type and Radioisotope on the Imaging Efficacy of 4 Fibrin-Specific PET Probes. J Nucl Med. 2014 Jul; 55(7):1157-63. PMID: 24790217.
    Citations: 11     Fields:    Translation:Animals
  80. Ay I, Blasi F, Rietz TA, Rotile NJ, Kura S, Brownell AL, Day H, Oliveira BL, Looby RJ, Caravan P. In vivo molecular imaging of thrombosis and thrombolysis using a fibrin-binding positron emission tomographic probe. Circ Cardiovasc Imaging. 2014 Jul; 7(4):697-705. PMID: 24777937.
    Citations: 16     Fields:    Translation:Animals
  81. Fuchs BC, Hoshida Y, Fujii T, Wei L, Yamada S, Lauwers GY, McGinn CM, DePeralta DK, Chen X, Kuroda T, Lanuti M, Schmitt AD, Gupta S, Crenshaw A, Onofrio R, Taylor B, Winckler W, Bardeesy N, Caravan P, Golub TR, Tanabe KK. Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. Hepatology. 2014 Apr; 59(4):1577-90. PMID: 24677197.
    Citations: 119     Fields:    Translation:HumansAnimalsCells
  82. Pierre VC, Allen MJ, Caravan P. Contrast agents for MRI: 30+ years and where are we going? J Biol Inorg Chem. 2014 Feb; 19(2):127-31. PMID: 24414380.
    Citations: 24     Fields:    
  83. Kolodziej AF, Zhang Z, Overoye-Chan K, Jacques V, Caravan P. Peptide optimization and conjugation strategies in the development of molecularly targeted magnetic resonance imaging contrast agents. Methods Mol Biol. 2014; 1088:185-211. PMID: 24146405.
    Citations: 10     Fields:    Translation:HumansCells
  84. Andronesi OC, Bhat H, Reuter M, Mukherjee S, Caravan P, Rosen BR. Whole brain mapping of water pools and molecular dynamics with rotating frame MR relaxation using gradient modulated low-power adiabatic pulses. Neuroimage. 2014 Apr 01; 89:92-109. PMID: 24345390.
    Citations: 6     Fields:    Translation:HumansCells
  85. Boros E, Rybak-Akimova E, Holland JP, Rietz T, Rotile N, Blasi F, Day H, Latifi R, Caravan P. Pycup--a bifunctional, cage-like ligand for (64)Cu radiolabeling. Mol Pharm. 2014 Feb 03; 11(2):617-29. PMID: 24294970.
    Citations: 10     Fields:    Translation:Animals
  86. Loving GS, Caravan P. Activation and retention: a magnetic resonance probe for the detection of acute thrombosis. Angew Chem Int Ed Engl. 2014 Jan 20; 53(4):1140-3. PMID: 24338877.
    Citations: 7     Fields:    Translation:HumansCells
  87. Caravan P, Yang Y, Zachariah R, Schmitt A, Mino-Kenudson M, Chen HH, Sosnovik DE, Dai G, Fuchs BC, Lanuti M. Molecular magnetic resonance imaging of pulmonary fibrosis in mice. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):1120-6. PMID: 23927643.
    Citations: 38     Fields:    Translation:HumansAnimals
  88. Gale EM, Zhu J, Caravan P. Direct measurement of the Mn(II) hydration state in metal complexes and metalloproteins through 17O NMR line widths. J Am Chem Soc. 2013 Dec 11; 135(49):18600-8. PMID: 24088013.
    Citations: 13     Fields:    
  89. Gale EM, Kenton N, Caravan P. [Gd(CyPic3A)(H2O)2]-: a stable, bis(aquated) and high-relaxivity Gd(III) complex. Chem Commun (Camb). 2013 Sep 21; 49(73):8060-2. PMID: 23903523.
    Citations: 6     Fields:    
  90. Fuchs BC, Wang H, Yang Y, Wei L, Polasek M, Schühle DT, Lauwers GY, Parkar A, Sinskey AJ, Tanabe KK, Caravan P. Molecular MRI of collagen to diagnose and stage liver fibrosis. J Hepatol. 2013 Nov; 59(5):992-8. PMID: 23838178.
    Citations: 54     Fields:    Translation:Animals
  91. Polasek M, Caravan P. Is macrocycle a synonym for kinetic inertness in Gd(III) Complexes? Effect of coordinating and noncoordinating substituents on inertness and relaxivity of Gd(III) chelates with DO3A-like ligands. Inorg Chem. 2013 Apr 01; 52(7):4084-96. PMID: 23517079.
    Citations: 11     Fields:    
  92. Loving GS, Mukherjee S, Caravan P. Redox-activated manganese-based MR contrast agent. J Am Chem Soc. 2013 Mar 27; 135(12):4620-3. PMID: 23510406.
    Citations: 36     Fields:    Translation:Cells
  93. Boros E, Caravan P. Structure-relaxivity relationships of serum albumin targeted MRI probes based on a single amino acid Gd complex. J Med Chem. 2013 Feb 28; 56(4):1782-6. PMID: 23391162.
    Citations: 8     Fields:    Translation:Cells
  94. Ciesienski KL, Yang Y, Ay I, Chonde DB, Loving GS, Rietz TA, Catana C, Caravan P. Fibrin-targeted PET probes for the detection of thrombi. Mol Pharm. 2013 Mar 04; 10(3):1100-10. PMID: 23327109.
    Citations: 21     Fields:    Translation:Animals
  95. Sosnovik DE, Caravan P. Molecular MRI of the Cardiovascular System in the Post-NSF Era. Curr Cardiovasc Imaging Rep. 2013 Feb 01; 6(1):61-68. PMID: 23504765.
  96. Boros E, Polasek M, Zhang Z, Caravan P. Gd(DOTAla): a single amino acid Gd-complex as a modular tool for high relaxivity MR contrast agent development. J Am Chem Soc. 2012 Dec 05; 134(48):19858-68. PMID: 23157602.
    Citations: 21     Fields:    Translation:HumansCells
  97. Uppal R, Medarova Z, Farrar CT, Dai G, Moore A, Caravan P. Molecular imaging of fibrin in a breast cancer xenograft mouse model. Invest Radiol. 2012 Oct; 47(10):553-8. PMID: 22960948.
    Citations: 13     Fields:    Translation:Animals
  98. Sosnovik DE, Nahrendorf M, Caravan P. Science to practice: how will myocardial inflammation be imaged with MR imaging? Radiology. 2012 Aug; 264(2):309-11. PMID: 22821689.
    Citations:    Fields:    Translation:AnimalsCells
  99. Uppal R, Ciesienski KL, Chonde DB, Loving GS, Caravan P. Discrete bimodal probes for thrombus imaging. J Am Chem Soc. 2012 Jul 04; 134(26):10799-802. PMID: 22698259.
    Citations: 9     Fields:    Translation:Humans
  100. Polasek M, Fuchs BC, Uppal R, Schühle DT, Alford JK, Loving GS, Yamada S, Wei L, Lauwers GY, Guimaraes AR, Tanabe KK, Caravan P. Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models. J Hepatol. 2012 Sep; 57(3):549-55. PMID: 22634342.
    Citations: 41     Fields:    Translation:Animals
  101. Caravan P, Zhang Z. Structure - relaxivity relationships among targeted MR contrast agents. Eur J Inorg Chem. 2012 Apr; 2012(12):1916-1923. PMID: 22745568.
    Citations: 13     
  102. Yang Y, Schühle DT, Dai G, Alford JK, Caravan P. 1H chemical shift magnetic resonance imaging probes with high sensitivity for multiplex imaging. Contrast Media Mol Imaging. 2012 Mar-Apr; 7(2):276-9. PMID: 22434641.
    Citations: 4     Fields:    
  103. Moriggi L, Yaseen MA, Helm L, Caravan P. Serum albumin targeted, pH-dependent magnetic resonance relaxation agents. Chemistry. 2012 Mar 19; 18(12):3675-86. PMID: 22328098.
    Citations: 11     Fields:    Translation:HumansCells
  104. Kolodziej AF, Nair SA, Graham P, McMurry TJ, Ladner RC, Wescott C, Sexton DJ, Caravan P. Fibrin specific peptides derived by phage display: characterization of peptides and conjugates for imaging. Bioconjug Chem. 2012 Mar 21; 23(3):548-56. PMID: 22263840.
    Citations: 31     Fields:    Translation:Cells
  105. Huang S, Chen HH, Yuan H, Dai G, Schuhle DT, Mekkaoui C, Ngoy S, Liao R, Caravan P, Josephson L, Sosnovik DE. Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium. Circ Cardiovasc Imaging. 2011 Nov; 4(6):729-37. PMID: 21836081.
    Citations: 26     Fields:    Translation:AnimalsCells
  106. Frullano L, Caravan P. Strategies for the preparation of bifunctional gadolinium(III) chelators. Curr Org Synth. 2011 Aug 01; 8(4):535-565. PMID: 22375102.
    Citations: 5     
  107. Zhang Z, Kolodziej AF, Greenfield MT, Caravan P. Heteroditopic binding of magnetic resonance contrast agents for increased relaxivity. Angew Chem Int Ed Engl. 2011 Mar 07; 50(11):2621-4. PMID: 21370351.
    Citations: 13     Fields:    Translation:HumansCells
  108. Uppal R, Catana C, Ay I, Benner T, Sorensen AG, Caravan P. Bimodal thrombus imaging: simultaneous PET/MR imaging with a fibrin-targeted dual PET/MR probe--feasibility study in rat model. Radiology. 2011 Mar; 258(3):812-20. PMID: 21177389.
    Citations: 33     Fields:    Translation:Animals
  109. Dumas S, Jacques V, Sun WC, Troughton JS, Welch JT, Chasse JM, Schmitt-Willich H, Caravan P. High relaxivity magnetic resonance imaging contrast agents. Part 1. Impact of single donor atom substitution on relaxivity of serum albumin-bound gadolinium complexes. Invest Radiol. 2010 Oct; 45(10):600-12. PMID: 20808235.
    Citations: 28     Fields:    Translation:HumansCells
  110. Jacques V, Dumas S, Sun WC, Troughton JS, Greenfield MT, Caravan P. High-relaxivity magnetic resonance imaging contrast agents. Part 2. Optimization of inner- and second-sphere relaxivity. Invest Radiol. 2010 Oct; 45(10):613-24. PMID: 20808234.
    Citations: 31     Fields:    Translation:HumansCells
  111. Lobbes MB, Heeneman S, Passos VL, Welten R, Kwee RM, van der Geest RJ, Wiethoff AJ, Caravan P, Misselwitz B, Daemen MJ, van Engelshoven JM, Leiner T, Kooi ME. Gadofosveset-enhanced magnetic resonance imaging of human carotid atherosclerotic plaques: a proof-of-concept study. Invest Radiol. 2010 May; 45(5):275-81. PMID: 20351652.
    Citations: 19     Fields:    Translation:Humans
  112. Uppal R, Ay I, Dai G, Kim YR, Sorensen AG, Caravan P. Molecular MRI of intracranial thrombus in a rat ischemic stroke model. Stroke. 2010 Jun; 41(6):1271-7. PMID: 20395615.
    Citations: 27     Fields:    Translation:Animals
  113. Frullano L, Catana C, Benner T, Sherry AD, Caravan P. Bimodal MR-PET agent for quantitative pH imaging. Angew Chem Int Ed Engl. 2010 Mar 22; 49(13):2382-4. PMID: 20191650.
    Citations: 43     Fields:    Translation:Cells
  114. Wang Y, Spiller M, Caravan P. Evidence for weak protein binding of commercial extracellular gadolinium contrast agents. Magn Reson Med. 2010 Mar; 63(3):609-16. PMID: 20146229.
    Citations: 13     Fields:    Translation:Cells
  115. Uppal R, Caravan P. Targeted probes for cardiovascular MRI. Future Med Chem. 2010 Mar; 2(3):451-70. PMID: 20539821.
    Citations: 13     Fields:    Translation:Cells
  116. Zhang Z, Kolodziej AF, Qi J, Nair SA, Wang X, Case AW, Greenfield MT, Graham PB, McMurry TJ, Caravan P. Effect of Peptide-Chelate Architecture on Metabolic Stability of Peptide-based MRI Contrast Agents. New J Chem. 2010 Feb 12; 2010(34):611-616. PMID: 20526382.
    Citations: 11     
  117. Ciesienski KL, Caravan P. Molecular MRI of Thrombosis. Curr Cardiovasc Imaging Rep. 2010; 4(1):77-84. PMID: 21253438.
    Citations: 16     
  118. Aime S, Caravan P. Biodistribution of gadolinium-based contrast agents, including gadolinium deposition. J Magn Reson Imaging. 2009 Dec; 30(6):1259-67. PMID: 19938038.
    Citations: 140     Fields:    Translation:HumansAnimals
  119. Sherry AD, Caravan P, Lenkinski RE. Primer on gadolinium chemistry. J Magn Reson Imaging. 2009 Dec; 30(6):1240-8. PMID: 19938036.
    Citations: 88     Fields:    Translation:HumansAnimals
  120. Vymazal J, Spuentrup E, Cardenas-Molina G, Wiethoff AJ, Hartmann MG, Caravan P, Parsons EC. Thrombus imaging with fibrin-specific gadolinium-based MR contrast agent EP-2104R: results of a phase II clinical study of feasibility. Invest Radiol. 2009 Nov; 44(11):697-704. PMID: 19809344.
    Citations: 56     Fields:    Translation:HumansCTClinical Trials
  121. Kraitchman DL, Caravan P. Magnetic resonance labeling of stem cells: is positive tracking a plus or a minus? JACC Cardiovasc Imaging. 2009 Sep; 2(9):1123-5. PMID: 19761993.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  122. Caravan P. Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of action. Acc Chem Res. 2009 Jul 21; 42(7):851-62. PMID: 19222207.
    Citations: 84     Fields:    Translation:HumansCells
  123. Sosnovik DE, Caravan P. Molecular MRI of Atherosclerotic Plaque With Targeted Contrast Agents. Curr Cardiovasc Imaging Rep. 2009 Apr 01; 2(2):87-94. PMID: 20019886.
    Citations: 4     
  124. Spuentrup E, Ruhl KM, Botnar RM, Wiethoff AJ, Buhl A, Jacques V, Greenfield MT, Krombach GA, Günther RW, Vangel MG, Caravan P. Molecular magnetic resonance imaging of myocardial perfusion with EP-3600, a collagen-specific contrast agent: initial feasibility study in a swine model. Circulation. 2009 Apr 07; 119(13):1768-75. PMID: 19307474.
    Citations: 24     Fields:    Translation:AnimalsCells
  125. Caravan P, Farrar CT, Frullano L, Uppal R. Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agents. Contrast Media Mol Imaging. 2009 Mar-Apr; 4(2):89-100. PMID: 19177472.
    Citations: 126     Fields:    
  126. Caravan P, Das B, Deng Q, Dumas S, Jacques V, Koerner SK, Kolodziej A, Looby RJ, Sun WC, Zhang Z. A lysine walk to high relaxivity collagen-targeted MRI contrast agents. Chem Commun (Camb). 2009 Jan 28; (4):430-2. PMID: 19137175.
    Citations: 12     Fields:    Translation:Cells
  127. Woods M, Caravan P, Geraldes CF, Greenfield MT, Kiefer GE, Lin M, McMillan K, Prata MI, Santos AC, Sun X, Wang J, Zhang S, Zhao P, Sherry AD. The effect of the amide substituent on the biodistribution and tolerance of lanthanide(III) DOTA-tetraamide derivatives. Invest Radiol. 2008 Dec; 43(12):861-70. PMID: 19002058.
    Citations: 9     Fields:    Translation:Animals
  128. Helm PA, Caravan P, French BA, Jacques V, Shen L, Xu Y, Beyers RJ, Roy RJ, Kramer CM, Epstein FH. Postinfarction myocardial scarring in mice: molecular MR imaging with use of a collagen-targeting contrast agent. Radiology. 2008 Jun; 247(3):788-96. PMID: 18403626.
    Citations: 65     Fields:    Translation:Animals
  129. Overoye-Chan K, Koerner S, Looby RJ, Kolodziej AF, Zech SG, Deng Q, Chasse JM, McMurry TJ, Caravan P. EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus. J Am Chem Soc. 2008 May 07; 130(18):6025-39. PMID: 18393503.
    Citations: 83     Fields:    Translation:HumansCells
  130. Ali MM, Woods M, Caravan P, Opina AC, Spiller M, Fettinger JC, Sherry AD. Synthesis and relaxometric studies of a dendrimer-based pH-responsive MRI contrast agent. Chemistry. 2008; 14(24):7250-8. PMID: 18601236.
    Citations: 34     Fields:    
  131. Nair SA, Kolodziej AF, Bhole G, Greenfield MT, McMurry TJ, Caravan P. Monovalent and bivalent fibrin-specific MRI contrast agents for detection of thrombus. Angew Chem Int Ed Engl. 2008; 47(26):4918-21. PMID: 18496805.
    Citations: 31     Fields:    Translation:AnimalsCells
  132. Tyeklar Z, Dunham SU, Midelfort K, Scott DM, Sajiki H, Ong K, Lauffer RB, Caravan P, McMurry TJ. Structural, kinetic, and thermodynamic characterization of the interconverting isomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agent. Inorg Chem. 2007 Aug 06; 46(16):6621-31. PMID: 17625838.
    Citations: 4     Fields:    
  133. Caravan P, Parigi G, Chasse JM, Cloutier NJ, Ellison JJ, Lauffer RB, Luchinat C, McDermid SA, Spiller M, McMurry TJ. Albumin binding, relaxivity, and water exchange kinetics of the diastereoisomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agent. Inorg Chem. 2007 Aug 06; 46(16):6632-9. PMID: 17625839.
    Citations: 56     Fields:    Translation:Cells
  134. Kalman FK, Woods M, Caravan P, Jurek P, Spiller M, Tircsó G, Kiraly R, Brücher E, Sherry AD. Potentiometric and relaxometric properties of a gadolinium-based MRI contrast agent for sensing tissue pH. Inorg Chem. 2007 Jun 25; 46(13):5260-70. PMID: 17539632.
    Citations: 42     Fields:    
  135. Zech SG, Eldredge HB, Lowe MP, Caravan P. Protein binding to lanthanide(III) complexes can reduce the water exchange rate at the lanthanide. Inorg Chem. 2007 Apr 30; 46(9):3576-84. PMID: 17425306.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  136. Caravan P, Das B, Dumas S, Epstein FH, Helm PA, Jacques V, Koerner S, Kolodziej A, Shen L, Sun WC, Zhang Z. Collagen-targeted MRI contrast agent for molecular imaging of fibrosis. Angew Chem Int Ed Engl. 2007; 46(43):8171-3. PMID: 17893943.
    Citations: 83     Fields:    Translation:HumansAnimals
  137. Raitsimring AM, Astashkin AV, Baute D, Goldfarb D, Poluektov OG, Lowe MP, Zech SG, Caravan P. Determination of the hydration number of gadolinium(III) complexes by high-field pulsed 17O ENDOR spectroscopy. Chemphyschem. 2006 Jul 17; 7(7):1590-7. PMID: 16810729.
    Citations: 8     Fields:    
  138. Caravan P. Strategies for increasing the sensitivity of gadolinium based MRI contrast agents. Chem Soc Rev. 2006 Jun; 35(6):512-23. PMID: 16729145.
    Citations: 235     Fields:    Translation:Cells
  139. Eldredge HB, Spiller M, Chasse JM, Greenwood MT, Caravan P. Species dependence on plasma protein binding and relaxivity of the gadolinium-based MRI contrast agent MS-325. Invest Radiol. 2006 Mar; 41(3):229-43. PMID: 16481905.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  140. Zech SG, Sun WC, Jacques V, Caravan P, Astashkin AV, Raitsimring AM. Probing the water coordination of protein-targeted MRI contrast agents by pulsed ENDOR spectroscopy. Chemphyschem. 2005 Dec 09; 6(12):2570-7. PMID: 16294353.
    Citations: 13     Fields:    Translation:Cells
  141. Zhang Z, Greenfield MT, Spiller M, McMurry TJ, Lauffer RB, Caravan P. Multilocus binding increases the relaxivity of protein-bound MRI contrast agents. Angew Chem Int Ed Engl. 2005 Oct 21; 44(41):6766-9. PMID: 16173108.
    Citations: 22     Fields:    Translation:HumansCells
  142. Caravan P, Amedio JC, Dunham SU, Greenfield MT, Cloutier NJ, McDermid SA, Spiller M, Zech SG, Looby RJ, Raitsimring AM, McMurry TJ, Lauffer RB. When are two waters worse than one? Doubling the hydration number of a Gd-DTPA derivative decreases relaxivity. Chemistry. 2005 Oct 07; 11(20):5866-74. PMID: 16052656.
    Citations: 8     Fields:    Translation:Cells
  143. Troughton JS, Greenfield MT, Greenwood JM, Dumas S, Wiethoff AJ, Wang J, Spiller M, McMurry TJ, Caravan P. Synthesis and evaluation of a high relaxivity manganese(II)-based MRI contrast agent. Inorg Chem. 2004 Oct 04; 43(20):6313-23. PMID: 15446878.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  144. Zhou X, Caravan P, Clarkson RB, Westlund PO. On the philosophy of optimizing contrast agents. An analysis of 1H NMRD profiles and ESR lineshapes of the Gd(III)complex MS-325+HSA. J Magn Reson. 2004 Mar; 167(1):147-60. PMID: 14987609.
    Citations: 5     Fields:    Translation:Humans
  145. Caravan P, Greenwood JM, Welch JT, Franklin SJ. Gadolinium-binding helix-turn-helix peptides: DNA-dependent MRI contrast agents. Chem Commun (Camb). 2003 Oct 21; (20):2574-5. PMID: 14594287.
    Citations: 12     Fields:    Translation:Cells
  146. Caravan P, Astashkin AV, Raitsimring AM. The gadolinium(III)-water hydrogen distance in MRI contrast agents. Inorg Chem. 2003 Jun 30; 42(13):3972-4. PMID: 12817950.
    Citations: 13     Fields:    
  147. Caravan P, Cloutier NJ, Greenfield MT, McDermid SA, Dunham SU, Bulte JW, Amedio JC, Looby RJ, Supkowski RM, Horrocks WD, McMurry TJ, Lauffer RB. The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates. J Am Chem Soc. 2002 Mar 27; 124(12):3152-62. PMID: 11902904.
    Citations: 98     Fields:    Translation:HumansCells
  148. Caravan P, Greenfield MT, Li X, Sherry AD. The Gd(3+) complex of a fatty acid analogue of DOTP binds to multiple albumin sites with variable water relaxivities. Inorg Chem. 2001 Dec 17; 40(26):6580-7. PMID: 11735466.
    Citations: 13     Fields:    Translation:HumansCells
  149. Caravan P, Greenfield MT, Bulte JW. Molecular factors that determine Curie spin relaxation in dysprosium complexes. Magn Reson Med. 2001 Nov; 46(5):917-22. PMID: 11675643.
    Citations: 8     Fields:    Translation:Humans
  150. Nivorozhkin AL, Kolodziej AF, Caravan P, Greenfield MT, Lauffer RB, McMurry TJ. Enzyme-Activated Gd(3+) Magnetic Resonance Imaging Contrast Agents with a Prominent Receptor-Induced Magnetization Enhancement We thank Dr. Shrikumar Nair for helpful discussions. Angew Chem Int Ed Engl. 2001 Aug 03; 40(15):2903-2906. PMID: 11500904.
    Citations: 21     Fields:    
  151. Nivorozhkin AL, Kolodziej AF, Caravan P, Greenfield MT, Lauffer RB, McMurry TJ. Enzyme-Activated Gd3+ Magnetic Resonance Imaging Contrast Agents with a Prominent Receptor-Induced Magnetization Enhancement. Angew Chem Int Ed Engl. 2001 Aug 03; 40(15):2903-2906. PMID: 29711998.
    Citations: 6     Fields:    
  152. Caravan P, Comuzzi C, Crooks W, McMurry TJ, Choppin GR, Woulfe SR. Thermodynamic stability and kinetic inertness of MS-325, a new blood pool agent for magnetic resonance imaging. Inorg Chem. 2001 Apr 23; 40(9):2170-6. PMID: 11304163.
    Citations: 9     Fields:    
  153. Caravan P, Ellison JJ, McMurry TJ, Lauffer RB. Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications. Chem Rev. 1999 Sep 08; 99(9):2293-352. PMID: 11749483.
    Citations: 597     Fields:    
  154. Yuen VG, Caravan P, Gelmini L, Glover N, McNeill JH, Setyawati IA, Zhou Y, Orvig C. Glucose-lowering properties of vanadium compounds: comparison of coordination complexes with maltol or kojic acid as ligands. J Inorg Biochem. 1997 Nov 01; 68(2):109-16. PMID: 9336969.
    Citations: 10     Fields:    Translation:Animals
  155. Caravan P, Mehrkhodavandi P, Orvig C. Cationic Lanthanide Complexes of N,N'-Bis(2-pyridylmethyl)ethylenediamine-N,N'-diacetic Acid (H(2)bped). Inorg Chem. 1997 Mar 26; 36(7):1316-1321. PMID: 11669707.
    Citations: 3     Fields:    
  156. Caravan P, Rettig SJ, Orvig C. Effect of Pyridyl Donors in the Chelation of Aluminum(III), Gallium(III), and Indium(III). Inorg Chem. 1997 Mar 26; 36(7):1306-1315. PMID: 11669706.
    Citations: 5     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.