Harvard Catalyst Profiles

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Steven M. Hersch, M.D., Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U44NS090616 (BROWNSTEIN, MICHAEL J) Sep 1, 2015 - Aug 31, 2019
    Tolerability of SRX246 in Huntington's Disease Patients
    Role: Co-Principal Investigator
  2. U01NS071789 (HERSCH, STEVEN M) Sep 30, 2010 - Aug 31, 2016
    Blood Level of Huntingtin: A Biomarker for Huntington's Disease
    Role: Principal Investigator
  3. P01NS058793 (HERSCH, STEVEN M) Jun 9, 2008 - Feb 28, 2014
    Biomarkers for Huntington's Disease: Accelerating the Development of Therapies
    Role: Principal Investigator
  4. R01FD003359 (HERSCH, STEVEN M) Jul 10, 2007 - Jun 30, 2011
    Role: Principal Investigator
  5. P01NS045242 (HERSCH, STEVEN M) Apr 15, 2003 - Mar 31, 2008
    Transcription and Therapy for HD: from Molecules to Man
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Maibach HT, Brownstein MJ, Hersch SM, Anderson KE, Itzkowitz DE, Damiano EM, Simon NG. The Vasopressin 1a Receptor Antagonist SRX246 Reduces Aggressive Behavior in Huntington's Disease. J Pers Med. 2022 Sep 22; 12(10). PMID: 36294700; PMCID: PMC9605366.
  2. McGarry A, Auinger P, Kieburtz KD, Bredlau AL, Hersch SM, Rosas HD. Suicidality Risk Factors Across the CARE-HD, 2CARE, and CREST-E Clinical Trials in Huntington Disease. Neurol Clin Pract. 2022 Apr; 12(2):131-138. PMID: 35747889; PMCID: PMC9208406.
  3. Langbehn DR, Fine EM, Meier A, Hersch S. Utility of the Huntington's Disease Prognostic Index Score for a Perimanifest Clinical Trial. Mov Disord. 2022 05; 37(5):1040-1046. PMID: 35170086; PMCID: PMC9306552.
    Citations:    Fields:    Translation:Humans
  4. Chan ST, Mercaldo ND, Kwong KK, Hersch SM, Rosas HD. Impaired Cerebrovascular Reactivity in Huntington's Disease. Front Physiol. 2021; 12:663898. PMID: 34366879; PMCID: PMC8334185.
    Citations: 1     
  5. Brownstein MJ, Simon NG, Long JD, Yankey J, Maibach HT, Cudkowicz M, Coffey C, Conwit RA, Lungu C, Anderson KE, Hersch SM, Ecklund DJ, Damiano EM, Itzkowitz DE, Lu S, Chase MK, Shefner JM, McGarry A, Thornell B, Gladden C, Costigan M, O'Suilleabhain P, Marshall FJ, Chesire AM, Deritis P, Adams JL, Hedera P, Lowen K, Rosas HD, Hiller AL, Quinn J, Keith K, Duker AP, Gruenwald C, Molloy A, Jacob C, Factor S, Sperin E, Bega D, Brown ZR, Seeberger LC, Sung VW, Benge M, Kostyk SK, Daley AM, Perlman S, Suski V, Conlon P, Barrett MJ, Lowenhaupt S, Quigg M, Perlmutter JS, Wright BA, Most E, Schwartz GJ, Lamb J, Chuang RS, Singer C, Marder K, Moran JA, Singleton JR, Zorn M, Wall PV, Dubinsky RM, Gray C, Drazinic C. Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington's Disease Patients-A Randomized Phase 2 Clinical Trial. J Clin Med. 2020 Nov 16; 9(11). PMID: 33207828.
    Citations: 2     
  6. Chan ST, Mercaldo ND, Ravina B, Hersch SM, Rosas HD. Association of Dilated Perivascular Spaces and Disease Severity in Patients With Huntington Disease. Neurology. 2021 02 09; 96(6):e890-e894. PMID: 33106388; PMCID: PMC8105900.
    Citations: 3     Fields:    Translation:Humans
  7. Langbehn DR, Hersch S. Clinical Outcomes and Selection Criteria for Prodromal Huntington's Disease Trials. Mov Disord. 2020 12; 35(12):2193-2200. PMID: 32686867.
    Citations: 2     Fields:    Translation:Humans
  8. Stietz MS, Liang X, Wong M, Hersch S, Dong TG. Double Tubular Contractile Structure of the Type VI Secretion System Displays Striking Flexibility and Elasticity. J Bacteriol. 2019 12 06; 202(1). PMID: 31636107; PMCID: PMC6932242.
    Citations: 5     Fields:    Translation:Cells
  9. Blair IA, Farmer J, Hersch S, Larkindale J, Lynch DR, Napierala J, Napierala M, Payne RM, Subramony SH. The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting. Future Sci OA. 2019 Jun 28; 5(6):FSO398. PMID: 31285843; PMCID: PMC6609901.
    Citations: 8     
  10. Kayson E, Eberly S, Anderson KE, Marder K, Shoulson I, Oakes D, Young AB, Biglan K, Hersch S. The Prospective Huntington At-Risk Observational Study (PHAROS): The Emotional Well-Being, Safety and Feasibility of Long-Term Research Participation. J Huntingtons Dis. 2019; 8(4):435-441. PMID: 31381523.
    Citations: 1     Fields:    Translation:Humans
  11. Stephen CD, Hung J, Schifitto G, Hersch SM, Rosas HD. Electrocardiogram Abnormalities Suggest Aberrant Cardiac Conduction in Huntington's Disease. Mov Disord Clin Pract. 2018 May-Jun; 5(3):306-311. PMID: 30363459; PMCID: PMC6174483.
    Citations: 10     
  12. Rosas HD, Wilkens P, Salat DH, Mercaldo ND, Vangel M, Yendiki AY, Hersch SM. Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease. Neuroimage Clin. 2018; 20:236-242. PMID: 30090698.
    Citations: 17     Fields:    Translation:HumansCells
  13. Schobel SA, Palermo G, Auinger P, Long JD, Ma S, Khwaja OS, Trundell D, Cudkowicz M, Hersch S, Sampaio C, Dorsey ER, Leavitt BR, Kieburtz KD, Sevigny JJ, Langbehn DR, Tabrizi SJ. Motor, cognitive, and functional declines contribute to a single progressive factor in early HD. Neurology. 2017 Dec 12; 89(24):2495-2502. PMID: 29142089.
    Citations: 32     Fields:    Translation:Humans
  14. Hersch SM, Schifitto G, Oakes D, Bredlau AL, Meyers CM, Nahin R, Rosas HD. The CREST-E study of creatine for Huntington disease: A randomized controlled trial. Neurology. 2017 Aug 08; 89(6):594-601. PMID: 28701493; PMCID: PMC5562960.
    Citations: 27     Fields:    Translation:Humans
  15. Quinti L, Dayalan Naidu S, Träger U, Chen X, Kegel-Gleason K, Llères D, Connolly C, Chopra V, Low C, Moniot S, Sapp E, Tousley AR, Vodicka P, Van Kanegan MJ, Kaltenbach LS, Crawford LA, Fuszard M, Higgins M, Miller JRC, Farmer RE, Potluri V, Samajdar S, Meisel L, Zhang N, Snyder A, Stein R, Hersch SM, Ellerby LM, Weerapana E, Schwarzschild MA, Steegborn C, Leavitt BR, Degterev A, Tabrizi SJ, Lo DC, DiFiglia M, Thompson LM, Dinkova-Kostova AT, Kazantsev AG. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients. Proc Natl Acad Sci U S A. 2017 06 06; 114(23):E4676-E4685. PMID: 28533375; PMCID: PMC5468652.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  16. Chopra V, Quinti L, Khanna P, Paganetti P, Kuhn R, Young AB, Kazantsev AG, Hersch S. LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington's Disease. J Huntingtons Dis. 2016 12 15; 5(4):347-355. PMID: 27983565.
    Citations: 12     Fields:    Translation:AnimalsCells
  17. Biglan KM, Shoulson I, Kieburtz K, Oakes D, Kayson E, Shinaman MA, Zhao H, Romer M, Young A, Hersch S, Penney J, Marder K, Paulsen J, Quaid K, Siemers E, Tanner C, Mallonee W, Suter G, Dubinsky R, Gray C, Nance M, Bundlie S, Radtke D, Kostyk S, Baic C, Caress J, Walker F, Hunt V, O'Neill C, Chouinard S, Factor S, Greenamyre T, Wood-Siverio C, Corey-Bloom J, Song D, Peavy G, Moskowitz C, Wesson M, Samii A, Bird T, Lipe H, Blindauer K, Marshall F, Zimmerman C, Goldstein J, Rosas D, Novak P, Caviness J, Adler C, Duffy A, Wheelock V, Tempkin T, Richman D, Seeberger L, Albin R, Chou KL, Racette B, Perlmutter JS, Perlman S, Bordelon Y, Martin W, Wieler M, Leavitt B, Raymond L, Decolongon J, Clarke L, Jankovic J, Hunter C, Hauser RA, Sanchez-Ramos J, Furtado S, Suchowersky O, Klimek ML, Guttman M, Sethna R, Feigin A, Cox M, Shannon B, Percy A, Dure L, Harrison M, Johnson W, Higgins D, Molho E, Nickerson C, Evans S, Hobson D, Singer C, Galvez-Jimenez N, Shannon K, Comella C, Ross C, Saint-Hilaire MH, Testa C, Rosenblatt A, Hogarth P, Weiner W, Como P, Kumar R, Cotto C, Stout J, Brocht A, Watts A, Eberly S, Weaver C, Foroud T, Gusella J, MacDonald M, Myers R, Fahn S, Shults C. Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials. JAMA Neurol. 2016 Jan; 73(1):102-10. PMID: 26569098.
    Citations: 22     Fields:    Translation:HumansCells
  18. Rosas HD, Doros G, Bhasin S, Thomas B, Gevorkian S, Malarick K, Matson W, Hersch SM. A systems-level "misunderstanding": the plasma metabolome in Huntington's disease. Ann Clin Transl Neurol. 2015 Jul; 2(7):756-68. PMID: 26273688.
    Citations: 20     Fields:    
  19. Narayanan KL, Chopra V, Rosas HD, Malarick K, Hersch S. Rho Kinase Pathway Alterations in the Brain and Leukocytes in Huntington's Disease. Mol Neurobiol. 2016 May; 53(4):2132-40. PMID: 25941073; PMCID: PMC4823347.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  20. Lu Z, Marks E, Chen J, Moline J, Barrows L, Raisbeck M, Volitakis I, Cherny RA, Chopra V, Bush AI, Hersch S, Fox JH. Altered selenium status in Huntington's disease: neuroprotection by selenite in the N171-82Q mouse model. Neurobiol Dis. 2014 Nov; 71:34-42. PMID: 25014023.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  21. Rosas HD, Doros G, Gevorkian S, Malarick K, Reuter M, Coutu JP, Triggs TD, Wilkens PJ, Matson W, Salat DH, Hersch SM. PRECREST: a phase II prevention and biomarker trial of creatine in at-risk Huntington disease. Neurology. 2014 Mar 11; 82(10):850-7. PMID: 24510496; PMCID: PMC3959748.
    Citations: 35     Fields:    Translation:HumansCTClinical Trials
  22. Chen J, Marks E, Lai B, Zhang Z, Duce JA, Lam LQ, Volitakis I, Bush AI, Hersch S, Fox JH. Iron accumulates in Huntington's disease neurons: protection by deferoxamine. PLoS One. 2013; 8(10):e77023. PMID: 24146952.
    Citations: 55     Fields:    Translation:AnimalsCells
  23. Moscovitch-Lopatin M, Goodman RE, Eberly S, Ritch JJ, Rosas HD, Matson S, Matson W, Oakes D, Young AB, Shoulson I, Hersch SM. HTRF analysis of soluble huntingtin in PHAROS PBMCs. Neurology. 2013 Sep 24; 81(13):1134-40. PMID: 23966247; PMCID: PMC3795598.
    Citations: 3     Fields:    Translation:HumansCells
  24. Ramos EM, Latourelle JC, Gillis T, Mysore JS, Squitieri F, Di Pardo A, Di Donato S, Gellera C, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Gusella JF, Lee JM, Alonso I, Sequeiros J, Myers RH, Macdonald ME. Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset. Neurogenetics. 2013 Nov; 14(3-4):173-9. PMID: 23644918.
    Citations: 3     Fields:    Translation:Humans
  25. Thomas B, Matson S, Chopra V, Sun L, Sharma S, Hersch S, Rosas HD, Scherzer C, Ferrante R, Matson W. A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease. Anal Biochem. 2013 May 15; 436(2):112-20. PMID: 23416183.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  26. Chopra V, Quinti L, Kim J, Vollor L, Narayanan KL, Edgerly C, Cipicchio PM, Lauver MA, Choi SH, Silverman RB, Ferrante RJ, Hersch S, Kazantsev AG. The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2012 Dec 27; 2(6):1492-7. PMID: 23200855.
    Citations: 75     Fields:    Translation:Animals
  27. Ramos EM, Latourelle JC, Lee JH, Gillis T, Mysore JS, Squitieri F, Di Pardo A, Di Donato S, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Marder K, Gusella JF, Lee JM, Alonso I, Sequeiros J, Myers RH, Macdonald ME. Population stratification may bias analysis of PGC-1a as a modifier of age at Huntington disease motor onset. Hum Genet. 2012 Dec; 131(12):1833-40. PMID: 22825315.
    Citations: 13     Fields:    Translation:HumansCells
  28. Lee JH, Lee JM, Ramos EM, Gillis T, Mysore JS, Kishikawa S, Hadzi T, Hendricks AE, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Squitieri F, Gellera C, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Landwehrmeyer GB, Shoulson I, Myers RH, MacDonald ME, Gusella JF. TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease. Biochem Biophys Res Commun. 2012 Aug 03; 424(3):404-8. PMID: 22771793.
    Citations: 7     Fields:    Translation:HumansCells
  29. Rosas HD, Chen YI, Doros G, Salat DH, Chen NK, Kwong KK, Bush A, Fox J, Hersch SM. Alterations in brain transition metals in Huntington disease: an evolving and intricate story. Arch Neurol. 2012 Jul; 69(7):887-93. PMID: 22393169; PMCID: PMC3652228.
    Citations: 56     Fields:    Translation:Humans
  30. Lee JM, Gillis T, Mysore JS, Ramos EM, Myers RH, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Squitieri F, Griguoli A, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, MacDonald ME, Gusella JF. Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region. Am J Hum Genet. 2012 Mar 09; 90(3):434-44. PMID: 22387017.
    Citations: 31     Fields:    Translation:HumansCells
  31. Lee JM, Ramos EM, Lee JH, Gillis T, Mysore JS, Hayden MR, Warby SC, Morrison P, Nance M, Ross CA, Margolis RL, Squitieri F, Orobello S, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Paulsen JS, Landwehrmeyer GB, Myers RH, MacDonald ME, Gusella JF. CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology. 2012 Mar 06; 78(10):690-5. PMID: 22323755; PMCID: PMC3306163.
    Citations: 140     Fields:    Translation:HumansCells
  32. Biglan KM, Dorsey ER, Evans RV, Ross CA, Hersch S, Shoulson I, Matson W, Kieburtz K. Plasma 8-hydroxy-2'-deoxyguanosine Levels in Huntington Disease and Healthy Controls Treated with Coenzyme Q10. J Huntingtons Dis. 2012; 1(1):65-9. PMID: 25063191.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  33. Hu Y, Chopra V, Chopra R, Locascio JJ, Liao Z, Ding H, Zheng B, Matson WR, Ferrante RJ, Rosas HD, Hersch SM, Scherzer CR. Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17141-6. PMID: 21969577.
    Citations: 44     Fields:    Translation:HumansAnimalsCTClinical Trials
  34. Maxwell MM, Tomkinson EM, Nobles J, Wizeman JW, Amore AM, Quinti L, Chopra V, Hersch SM, Kazantsev AG. The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS. Hum Mol Genet. 2011 Oct 15; 20(20):3986-96. PMID: 21791548.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  35. Rosas HD, Reuter M, Doros G, Lee SY, Triggs T, Malarick K, Fischl B, Salat DH, Hersch SM. A tale of two factors: what determines the rate of progression in Huntington's disease? A longitudinal MRI study. Mov Disord. 2011 Aug 01; 26(9):1691-7. PMID: 21611979.
    Citations: 19     Fields:    Translation:HumansCells
  36. Fox JH, Connor T, Stiles M, Kama J, Lu Z, Dorsey K, Lieberman G, Liebermann G, Sapp E, Cherny RA, Banks M, Volitakis I, DiFiglia M, Berezovska O, Bush AI, Hersch SM. Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein. J Biol Chem. 2011 May 20; 286(20):18320-30. PMID: 21454633.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  37. Moscovitch-Lopatin M, Weiss A, Rosas HD, Ritch J, Doros G, Kegel KB, Difiglia M, Kuhn R, Bilbe G, Paganetti P, Hersch S. Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease. PLoS Curr. 2010 Dec 29; 2:RRN1205. PMID: 21278900.
    Citations: 10     
  38. Weiss A, Grueninger S, Abramowski D, Giorgio FP, Lopatin MM, Rosas HD, Hersch S, Paganetti P. Microtiter plate quantification of mutant and wild-type huntingtin normalized to cell count. Anal Biochem. 2011 Mar 15; 410(2):304-6. PMID: 21134349.
    Citations: 12     Fields:    Translation:HumansCells
  39. Quinti L, Chopra V, Rotili D, Valente S, Amore A, Franci G, Meade S, Valenza M, Altucci L, Maxwell MM, Cattaneo E, Hersch S, Mai A, Kazantsev A. Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model. PLoS Curr. 2010 Sep 02; 2. PMID: 20877454.
    Citations: 19     
  40. Fox JH, Connor T, Chopra V, Dorsey K, Kama JA, Bleckmann D, Betschart C, Hoyer D, Frentzel S, Difiglia M, Paganetti P, Hersch SM. The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease. Mol Neurodegener. 2010 Jun 22; 5:26. PMID: 20569486.
    Citations: 47     Fields:    
  41. Kim J, Amante DJ, Moody JP, Edgerly CK, Bordiuk OL, Smith K, Matson SA, Matson WR, Scherzer CR, Rosas HD, Hersch SM, Ferrante RJ. Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease. Biochim Biophys Acta. 2010 Jul-Aug; 1802(7-8):673-81. PMID: 20460152.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  42. Ebbel EN, Leymarie N, Schiavo S, Sharma S, Gevorkian S, Hersch S, Matson WR, Costello CE. Identification of phenylbutyrate-generated metabolites in Huntington disease patients using parallel liquid chromatography/electrochemical array/mass spectrometry and off-line tandem mass spectrometry. Anal Biochem. 2010 Apr 15; 399(2):152-61. PMID: 20074541.
    Citations: 15     Fields:    Translation:Humans
  43. Rosas HD, Lee SY, Bender AC, Zaleta AK, Vangel M, Yu P, Fischl B, Pappu V, Onorato C, Cha JH, Salat DH, Hersch SM. Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection". Neuroimage. 2010 Feb 15; 49(4):2995-3004. PMID: 19850138.
    Citations: 108     Fields:    Translation:HumansCells
  44. Weiss A, Abramowski D, Bibel M, Bodner R, Chopra V, DiFiglia M, Fox J, Kegel K, Klein C, Grueninger S, Hersch S, Housman D, Régulier E, Rosas HD, Stefani M, Zeitlin S, Bilbe G, Paganetti P. Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease. Anal Biochem. 2009 Dec 01; 395(1):8-15. PMID: 19664996.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  45. Brocklebank D, Gayán J, Andresen JM, Roberts SA, Young AB, Snodgrass SR, Penney JB, Ramos-Arroyo MA, Cha JJ, Rosas HD, Hersch SM, Feigin A, Cherny SS, Wexler NS, Housman DE, Cardon LR. Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications. Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 05; 150B(3):425-9. PMID: 18712713.
    Citations: 6     Fields:    Translation:HumansCells
  46. Rosas HD, Salat DH, Lee SY, Zaleta AK, Hevelone N, Hersch SM. Complexity and heterogeneity: what drives the ever-changing brain in Huntington's disease? Ann N Y Acad Sci. 2008 Dec; 1147:196-205. PMID: 19076442.
    Citations: 21     Fields:    Translation:Humans
  47. Liu W, Kennington LA, Rosas HD, Hersch S, Cha JH, Zamore PD, Aronin N. Linking SNPs to CAG repeat length in Huntington's disease patients. Nat Methods. 2008 Nov; 5(11):951-3. PMID: 18931668; PMCID: PMC2587014.
    Citations: 17     Fields:    Translation:HumansCells
  48. Schiavo S, Ebbel E, Sharma S, Matson W, Kristal BS, Hersch S, Vouros P. Metabolite identification using a nanoelectrospray LC-EC-array-MS integrated system. Anal Chem. 2008 Aug 01; 80(15):5912-23. PMID: 18576668.
    Citations: 14     Fields:    Translation:Humans
  49. Hersch SM, Rosas HD. Neuroprotection for Huntington's disease: ready, set, slow. Neurotherapeutics. 2008 Apr; 5(2):226-36. PMID: 18394565.
    Citations: 15     Fields:    Translation:Humans
  50. Rosas HD, Salat DH, Lee SY, Zaleta AK, Pappu V, Fischl B, Greve D, Hevelone N, Hersch SM. Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity. Brain. 2008 Apr; 131(Pt 4):1057-68. PMID: 18337273; PMCID: PMC2657201.
    Citations: 177     Fields:    Translation:Humans
  51. Stack EC, Dedeoglu A, Smith KM, Cormier K, Kubilus JK, Bogdanov M, Matson WR, Yang L, Jenkins BG, Luthi-Carter R, Kowall NW, Hersch SM, Beal MF, Ferrante RJ. Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice. J Neurosci. 2007 Nov 21; 27(47):12908-15. PMID: 18032664.
    Citations: 34     Fields:    Translation:AnimalsCells
  52. Chopra V, Fox JH, Lieberman G, Dorsey K, Matson W, Waldmeier P, Housman DE, Kazantsev A, Young AB, Hersch S. A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16685-9. PMID: 17925440.
    Citations: 52     Fields:    Translation:AnimalsCells
  53. Erwin C, Hersch S. Monitoring reportable events and unanticipated problems: the PHAROS and PREDICT studies of Huntington disease. IRB. 2007 May-Jun; 29(3):11-6. PMID: 17847637.
    Citations: 2     Fields:    Translation:Humans
  54. Sadri-Vakili G, Bouzou B, Benn CL, Kim MO, Chawla P, Overland RP, Glajch KE, Xia E, Qiu Z, Hersch SM, Clark TW, Yohrling GJ, Cha JH. Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models. Hum Mol Genet. 2007 Jun 01; 16(11):1293-306. PMID: 17409194.
    Citations: 82     Fields:    Translation:AnimalsCells
  55. Fox JH, Kama JA, Lieberman G, Chopra R, Dorsey K, Chopra V, Volitakis I, Cherny RA, Bush AI, Hersch S. Mechanisms of copper ion mediated Huntington's disease progression. PLoS One. 2007 Mar 28; 2(3):e334. PMID: 17396163.
    Citations: 49     Fields:    Translation:HumansAnimals
  56. Kazantsev AG, Hersch SM. Drug targeting of dysregulated transcription in Huntington's disease. Prog Neurobiol. 2007 Nov; 83(4):249-59. PMID: 17379386; PMCID: PMC2110959.
    Citations: 8     Fields:    Translation:HumansCells
  57. Rosas HD, Tuch DS, Hevelone ND, Zaleta AK, Vangel M, Hersch SM, Salat DH. Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measures. Mov Disord. 2006 Sep; 21(9):1317-25. PMID: 16755582.
    Citations: 136     Fields:    Translation:HumansCells
  58. Li JL, Hayden MR, Warby SC, Durr A, Morrison PJ, Nance M, Ross CA, Margolis RL, Rosenblatt A, Squitieri F, Frati L, Gómez-Tortosa E, García CA, Suchowersky O, Klimek ML, Trent RJ, McCusker E, Novelletto A, Frontali M, Paulsen JS, Jones R, Ashizawa T, Lazzarini A, Wheeler VC, Prakash R, Xu G, Djoussé L, Mysore JS, Gillis T, Hakky M, Cupples LA, Saint-Hilaire MH, Cha JH, Hersch SM, Penney JB, Harrison MB, Perlman SL, Zanko A, Abramson RK, Lechich AJ, Duckett A, Marder K, Conneally PM, Gusella JF, MacDonald ME, Myers RH. Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study. BMC Med Genet. 2006 Aug 17; 7:71. PMID: 16914060; PMCID: PMC1586197.
    Citations: 34     Fields:    Translation:HumansCells
  59. Altmann SM, Muryshev A, Fossale E, Maxwell MM, Norflus FN, Fox J, Hersch SM, Young AB, MacDonald ME, Abagyan R, Kazantsev AG. Discovery of bioactive small-molecule inhibitor of poly adp-ribose polymerase: implications for energy-deficient cells. Chem Biol. 2006 Jul; 13(7):765-70. PMID: 16873024.
    Citations: 4     Fields:    Translation:HumansCells
  60. Qiu Z, Norflus F, Singh B, Swindell MK, Buzescu R, Bejarano M, Chopra R, Zucker B, Benn CL, DiRocco DP, Cha JH, Ferrante RJ, Hersch SM. Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective. J Biol Chem. 2006 Jun 16; 281(24):16672-80. PMID: 16595660.
    Citations: 50     Fields:    Translation:AnimalsCells
  61. Hersch SM, Gevorkian S, Marder K, Moskowitz C, Feigin A, Cox M, Como P, Zimmerman C, Lin M, Zhang L, Ulug AM, Beal MF, Matson W, Bogdanov M, Ebbel E, Zaleta A, Kaneko Y, Jenkins B, Hevelone N, Zhang H, Yu H, Schoenfeld D, Ferrante R, Rosas HD. Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG. Neurology. 2006 Jan 24; 66(2):250-2. PMID: 16434666.
    Citations: 101     Fields:    Translation:Humans
  62. Stack EC, Kubilus JK, Smith K, Cormier K, Del Signore SJ, Guelin E, Ryu H, Hersch SM, Ferrante RJ. Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice. J Comp Neurol. 2005 Oct 03; 490(4):354-70. PMID: 16127709.
    Citations: 111     Fields:    Translation:AnimalsCells
  63. Ryu H, Rosas HD, Hersch SM, Ferrante RJ. The therapeutic role of creatine in Huntington's disease. Pharmacol Ther. 2005 Nov; 108(2):193-207. PMID: 16055197.
    Citations: 19     Fields:    Translation:HumansAnimals
  64. Puri BK, Leavitt BR, Hayden MR, Ross CA, Rosenblatt A, Greenamyre JT, Hersch S, Vaddadi KS, Sword A, Horrobin DF, Manku M, Murck H. Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial. Neurology. 2005 Jul 26; 65(2):286-92. PMID: 16043801.
    Citations: 41     Fields:    Translation:HumansCells
  65. Borovecki F, Lovrecic L, Zhou J, Jeong H, Then F, Rosas HD, Hersch SM, Hogarth P, Bouzou B, Jensen RV, Krainc D. Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11023-8. PMID: 16043692; PMCID: PMC1182457.
    Citations: 160     Fields:    Translation:HumansCells
  66. Christie MA, Hersch SM. Demonstration of nondeclarative sequence learning in mice: development of an animal analog of the human serial reaction time task. Learn Mem. 2004 Nov-Dec; 11(6):720-3. PMID: 15537741.
    Citations: 4     Fields:    Translation:HumansAnimals
  67. Norflus F, Nanje A, Gutekunst CA, Shi G, Cohen J, Bejarano M, Fox J, Ferrante RJ, Hersch SM. Anti-inflammatory treatment with acetylsalicylate or rofecoxib is not neuroprotective in Huntington's disease transgenic mice. Neurobiol Dis. 2004 Nov; 17(2):319-25. PMID: 15474369.
    Citations: 16     Fields:    Translation:Animals
  68. Fox JH, Barber DS, Singh B, Zucker B, Swindell MK, Norflus F, Buzescu R, Chopra R, Ferrante RJ, Kazantsev A, Hersch SM. Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation. J Neurochem. 2004 Oct; 91(2):413-22. PMID: 15447674.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  69. Hersch SM, Ferrante RJ. Translating therapies for Huntington's disease from genetic animal models to clinical trials. NeuroRx. 2004 Jul; 1(3):298-306. PMID: 15717031.
    Citations: 26     Fields:    Translation:HumansAnimals
  70. Rosas HD, Feigin AS, Hersch SM. Using advances in neuroimaging to detect, understand, and monitor disease progression in Huntington's disease. NeuroRx. 2004 Apr; 1(2):263-72. PMID: 15717027.
    Citations: 18     Fields:    Translation:Humans
  71. Wexler NS, Lorimer J, Porter J, Gomez F, Moskowitz C, Shackell E, Marder K, Penchaszadeh G, Roberts SA, Gayán J, Brocklebank D, Cherny SS, Cardon LR, Gray J, Dlouhy SR, Wiktorski S, Hodes ME, Conneally PM, Penney JB, Gusella J, Cha JH, Irizarry M, Rosas D, Hersch S, Hollingsworth Z, MacDonald M, Young AB, Andresen JM, Housman DE, De Young MM, Bonilla E, Stillings T, Negrette A, Snodgrass SR, Martinez-Jaurrieta MD, Ramos-Arroyo MA, Bickham J, Ramos JS, Marshall F, Shoulson I, Rey GJ, Feigin A, Arnheim N, Acevedo-Cruz A, Acosta L, Alvir J, Fischbeck K, Thompson LM, Young A, Dure L, O'Brien CJ, Paulsen J, Brickman A, Krch D, Peery S, Hogarth P, Higgins DS, Landwehrmeyer B. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3498-503. PMID: 14993615; PMCID: PMC373491.
    Citations: 251     Fields:    Translation:HumansCells
  72. Hersch S, Fink K, Vonsattel JP, Friedlander RM. Minocycline is protective in a mouse model of Huntington's disease. Ann Neurol. 2003 Dec; 54(6):841; author reply 842-3. PMID: 14681897.
    Citations: 11     Fields:    Translation:Animals
  73. Ferrante RJ, Kubilus JK, Lee J, Ryu H, Beesen A, Zucker B, Smith K, Kowall NW, Ratan RR, Luthi-Carter R, Hersch SM. Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J Neurosci. 2003 Oct 15; 23(28):9418-27. PMID: 14561870; PMCID: PMC6740577.
    Citations: 259     Fields:    Translation:AnimalsCells
  74. Li JL, Hayden MR, Almqvist EW, Brinkman RR, Durr A, Dodé C, Morrison PJ, Suchowersky O, Ross CA, Margolis RL, Rosenblatt A, Gómez-Tortosa E, Cabrero DM, Novelletto A, Frontali M, Nance M, Trent RJ, McCusker E, Jones R, Paulsen JS, Harrison M, Zanko A, Abramson RK, Russ AL, Knowlton B, Djoussé L, Mysore JS, Tariot S, Gusella MF, Wheeler VC, Atwood LD, Cupples LA, Saint-Hilaire M, Cha JH, Hersch SM, Koroshetz WJ, Gusella JF, MacDonald ME, Myers RH. A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study. Am J Hum Genet. 2003 Sep; 73(3):682-7. PMID: 12900792; PMCID: PMC1180695.
    Citations: 60     Fields:    Translation:HumansCells
  75. Hersch SM. Huntington's disease: prospects for neuroprotective therapy 10 years after the discovery of the causative genetic mutation. Curr Opin Neurol. 2003 Aug; 16(4):501-6. PMID: 12869810.
    Citations: 5     Fields:    Translation:Humans
  76. Dedeoglu A, Kubilus JK, Yang L, Ferrante KL, Hersch SM, Beal MF, Ferrante RJ. Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice. J Neurochem. 2003 Jun; 85(6):1359-67. PMID: 12787055; PMCID: PMC2866522.
    Citations: 49     Fields:    Translation:Animals
  77. Apostol BL, Kazantsev A, Raffioni S, Illes K, Pallos J, Bodai L, Slepko N, Bear JE, Gertler FB, Hersch S, Housman DE, Marsh JL, Thompson LM. A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5950-5. PMID: 12730384; PMCID: PMC156307.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  78. Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Hum Mol Genet. 2002 Nov 01; 11(23):2815-28. PMID: 12393793.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  79. Dedeoglu A, Kubilus JK, Jeitner TM, Matson SA, Bogdanov M, Kowall NW, Matson WR, Cooper AJ, Ratan RR, Beal MF, Hersch SM, Ferrante RJ. Therapeutic effects of cystamine in a murine model of Huntington's disease. J Neurosci. 2002 Oct 15; 22(20):8942-50. PMID: 12388601; PMCID: PMC6757687.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  80. Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen KE, Staal R, Tieu K, Schmitz Y, Yuan CA, Rocha M, Jackson-Lewis V, Hersch S, Sulzer D, Przedborski S, Burke R, Hen R. Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14524-9. PMID: 12376616; PMCID: PMC137916.
    Citations: 217     Fields:    Translation:HumansAnimalsCells
  81. Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. J Neurosci. 2002 Sep 15; 22(18):7862-72. PMID: 12223539; PMCID: PMC6758089.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  82. Meade CA, Deng YP, Fusco FR, Del Mar N, Hersch S, Goldowitz D, Reiner A. Cellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic mice. J Comp Neurol. 2002 Jul 29; 449(3):241-69. PMID: 12115678.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  83. Dunah AW, Jeong H, Griffin A, Kim YM, Standaert DG, Hersch SM, Mouradian MM, Young AB, Tanese N, Krainc D. Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. Science. 2002 Jun 21; 296(5576):2238-43. PMID: 11988536.
    Citations: 238     Fields:    Translation:HumansAnimalsCells
  84. Wheeler VC, Gutekunst CA, Vrbanac V, Lebel LA, Schilling G, Hersch S, Friedlander RM, Gusella JF, Vonsattel JP, Borchelt DR, MacDonald ME. Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice. Hum Mol Genet. 2002 Mar 15; 11(6):633-40. PMID: 11912178.
    Citations: 75     Fields:    Translation:AnimalsCells
  85. Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH, van der Kouwe A, Jenkins BG, Dale AM, Fischl B. Regional and progressive thinning of the cortical ribbon in Huntington's disease. Neurology. 2002 Mar 12; 58(5):695-701. PMID: 11889230.
    Citations: 417     Fields:    Translation:Humans
  86. Ferrante RJ, Andreassen OA, Dedeoglu A, Ferrante KL, Jenkins BG, Hersch SM, Beal MF. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J Neurosci. 2002 Mar 01; 22(5):1592-9. PMID: 11880489; PMCID: PMC6758854.
    Citations: 125     Fields:    Translation:HumansAnimals
  87. Kiechle T, Dedeoglu A, Kubilus J, Kowall NW, Beal MF, Friedlander RM, Hersch SM, Ferrante RJ. Cytochrome C and caspase-9 expression in Huntington's disease. Neuromolecular Med. 2002; 1(3):183-95. PMID: 12095160.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  88. Hersch SM, Rosas HD. 10 most commonly asked questions about Huntington's disease. Neurologist. 2001 Nov; 7(6):364-8. PMID: 14649632.
    Citations:    Fields:    
  89. Hersch SM, Rosas HD. Neuroprotective therapy for Huntington's disease: new prospects and challenges. Expert Rev Neurother. 2001 Sep; 1(1):111-8. PMID: 19811052.
    Citations:    Fields:    
  90. Alcantara AA, Mrzljak L, Jakab RL, Levey AI, Hersch SM, Goldman-Rakic PS. Muscarinic m1 and m2 receptor proteins in local circuit and projection neurons of the primate striatum: anatomical evidence for cholinergic modulation of glutamatergic prefronto-striatal pathways. J Comp Neurol. 2001 Jun 11; 434(4):445-60. PMID: 11343292.
    Citations: 42     Fields:    Translation:AnimalsCells
  91. Andreassen OA, Dedeoglu A, Ferrante RJ, Jenkins BG, Ferrante KL, Thomas M, Friedlich A, Browne SE, Schilling G, Borchelt DR, Hersch SM, Ross CA, Beal MF. Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiol Dis. 2001 Jun; 8(3):479-91. PMID: 11447996.
    Citations: 77     Fields:    Translation:AnimalsCells
  92. Yi H, Leunissen J, Shi G, Gutekunst C, Hersch S. A novel procedure for pre-embedding double immunogold-silver labeling at the ultrastructural level. J Histochem Cytochem. 2001 Mar; 49(3):279-84. PMID: 11181730.
    Citations: 38     Fields:    Translation:AnimalsCells
  93. Freeman TB, Cicchetti F, Hauser RA, Deacon TW, Li XJ, Hersch SM, Nauert GM, Sanberg PR, Kordower JH, Saporta S, Isacson O. Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13877-82. PMID: 11106399; PMCID: PMC17669.
    Citations: 48     Fields:    Translation:Humans
  94. Thomas TM, Smith Y, Levey AI, Hersch SM. Cortical inputs to m2-immunoreactive striatal interneurons in rat and monkey. Synapse. 2000 Sep 15; 37(4):252-61. PMID: 10891862.
    Citations: 36     Fields:    Translation:AnimalsCells
  95. Gutekunst CA, Norflus F, Hersch SM. Recent advances in Huntington's disease. Curr Opin Neurol. 2000 Aug; 13(4):445-50. PMID: 10970063.
    Citations: 3     Fields:    Translation:HumansAnimals
  96. Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L, Farrell LA, Hersch SM, Hobbs W, Vonsattel JP, Cha JH, Friedlander RM. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med. 2000 Jul; 6(7):797-801. PMID: 10888929.
    Citations: 303     Fields:    Translation:AnimalsCells
  97. Ferrante RJ, Andreassen OA, Jenkins BG, Dedeoglu A, Kuemmerle S, Kubilus JK, Kaddurah-Daouk R, Hersch SM, Beal MF. Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci. 2000 Jun 15; 20(12):4389-97. PMID: 10844007; PMCID: PMC6772461.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  98. Wheeler VC, White JK, Gutekunst CA, Vrbanac V, Weaver M, Li XJ, Li SH, Yi H, Vonsattel JP, Gusella JF, Hersch S, Auerbach W, Joyner AL, MacDonald ME. Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice. Hum Mol Genet. 2000 Mar 01; 9(4):503-13. PMID: 10699173.
    Citations: 159     Fields:    Translation:AnimalsCells
  99. Kuemmerle S, Gutekunst CA, Klein AM, Li XJ, Li SH, Beal MF, Hersch SM, Ferrante RJ. Huntington aggregates may not predict neuronal death in Huntington's disease. Ann Neurol. 1999 Dec; 46(6):842-9. PMID: 10589536.
    Citations: 115     Fields:    Translation:HumansCells
  100. Hackam AS, Hodgson JG, Singaraja R, Zhang T, Gan L, Gutekunst CA, Hersch SM, Hayden MR. Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin. Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29; 354(1386):1047-55. PMID: 10434304; PMCID: PMC1692613.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  101. Taylor AK, Tassone F, Dyer PN, Hersch SM, Harris JB, Greenough WT, Hagerman RJ. Tissue heterogeneity of the FMR1 mutation in a high-functioning male with fragile X syndrome. Am J Med Genet. 1999 May 28; 84(3):233-9. PMID: 10331599.
    Citations: 28     Fields:    Translation:HumansCells
  102. Hodgson JG, Agopyan N, Gutekunst CA, Leavitt BR, LePiane F, Singaraja R, Smith DJ, Bissada N, McCutcheon K, Nasir J, Jamot L, Li XJ, Stevens ME, Rosemond E, Roder JC, Phillips AG, Rubin EM, Hersch SM, Hayden MR. A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron. 1999 May; 23(1):181-92. PMID: 10402204.
    Citations: 267     Fields:    Translation:AnimalsCells
  103. Gutekunst CA, Li SH, Yi H, Mulroy JS, Kuemmerle S, Jones R, Rye D, Ferrante RJ, Hersch SM, Li XJ. Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology. J Neurosci. 1999 Apr 01; 19(7):2522-34. PMID: 10087066; PMCID: PMC6786077.
    Citations: 307     Fields:    Translation:HumansCells
  104. Li SH, Gutekunst CA, Hersch SM, Li XJ. Association of HAP1 isoforms with a unique cytoplasmic structure. J Neurochem. 1998 Nov; 71(5):2178-85. PMID: 9798945.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  105. Klement IA, Skinner PJ, Kaytor MD, Yi H, Hersch SM, Clark HB, Zoghbi HY, Orr HT. Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell. 1998 Oct 02; 95(1):41-53. PMID: 9778246.
    Citations: 284     Fields:    Translation:AnimalsCells
  106. Gutekunst CA, Li SH, Yi H, Ferrante RJ, Li XJ, Hersch SM. The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. J Neurosci. 1998 Oct 01; 18(19):7674-86. PMID: 9742138; PMCID: PMC6793025.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  107. Li SH, Hosseini SH, Gutekunst CA, Hersch SM, Ferrante RJ, Li XJ. A human HAP1 homologue. Cloning, expression, and interaction with huntingtin. J Biol Chem. 1998 Jul 24; 273(30):19220-7. PMID: 9668110.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  108. Li SH, Gutekunst CA, Hersch SM, Li XJ. Interaction of huntingtin-associated protein with dynactin P150Glued. J Neurosci. 1998 Feb 15; 18(4):1261-9. PMID: 9454836; PMCID: PMC6792727.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  109. Ordway JM, Tallaksen-Greene S, Gutekunst CA, Bernstein EM, Cearley JA, Wiener HW, Dure LS, Lindsey R, Hersch SM, Jope RS, Albin RL, Detloff PJ. Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse. Cell. 1997 Dec 12; 91(6):753-63. PMID: 9413985.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  110. Hersch SM, Yi H, Heilman CJ, Edwards RH, Levey AI. Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra. J Comp Neurol. 1997 Nov 17; 388(2):211-27. PMID: 9368838.
    Citations: 75     Fields:    Translation:AnimalsCells
  111. Ferrante RJ, Gutekunst CA, Persichetti F, McNeil SM, Kowall NW, Gusella JF, MacDonald ME, Beal MF, Hersch SM. Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum. J Neurosci. 1997 May 01; 17(9):3052-63. PMID: 9096140; PMCID: PMC6573626.
    Citations: 41     Fields:    Translation:Humans
  112. Feng Y, Gutekunst CA, Eberhart DE, Yi H, Warren ST, Hersch SM. Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes. J Neurosci. 1997 Mar 01; 17(5):1539-47. PMID: 9030614; PMCID: PMC6573369.
    Citations: 195     Fields:    Translation:HumansAnimalsCells
  113. Gilmor ML, Nash NR, Roghani A, Edwards RH, Yi H, Hersch SM, Levey AI. Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles. J Neurosci. 1996 Apr 01; 16(7):2179-90. PMID: 8601799; PMCID: PMC6578528.
    Citations: 67     Fields:    Translation:AnimalsCells
  114. Bradley SR, Levey AI, Hersch SM, Conn PJ. Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies. J Neurosci. 1996 Mar 15; 16(6):2044-56. PMID: 8604049; PMCID: PMC6578504.
    Citations: 49     Fields:    Translation:AnimalsCells
  115. Gutekunst CA, Levey AI, Heilman CJ, Whaley WL, Yi H, Nash NR, Rees HD, Madden JJ, Hersch SM. Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8710-4. PMID: 7568002; PMCID: PMC41036.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  116. Hersch SM, Ciliax BJ, Gutekunst CA, Rees HD, Heilman CJ, Yung KK, Bolam JP, Ince E, Yi H, Levey AI. Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents. J Neurosci. 1995 Jul; 15(7 Pt 2):5222-37. PMID: 7623147; PMCID: PMC6577913.
    Citations: 147     Fields:    Translation:AnimalsCells
  117. Yung KK, Bolam JP, Smith AD, Hersch SM, Ciliax BJ, Levey AI. Immunocytochemical localization of D1 and D2 dopamine receptors in the basal ganglia of the rat: light and electron microscopy. Neuroscience. 1995 Apr; 65(3):709-30. PMID: 7609871.
    Citations: 149     Fields:    Translation:AnimalsCells
  118. Ciliax BJ, Heilman C, Demchyshyn LL, Pristupa ZB, Ince E, Hersch SM, Niznik HB, Levey AI. The dopamine transporter: immunochemical characterization and localization in brain. J Neurosci. 1995 Mar; 15(3 Pt 1):1714-23. PMID: 7534339; PMCID: PMC6578165.
    Citations: 152     Fields:    Translation:HumansAnimalsCells
  119. Levey AI, Edmunds SM, Hersch SM, Wiley RG, Heilman CJ. Light and electron microscopic study of m2 muscarinic acetylcholine receptor in the basal forebrain of the rat. J Comp Neurol. 1995 Jan 16; 351(3):339-56. PMID: 7706546.
    Citations: 36     Fields:    Translation:AnimalsCells
  120. Hersch SM, Levey AI. Diverse pre- and post-synaptic expression of m1-m4 muscarinic receptor proteins in neurons and afferents in the rat neostriatum. Life Sci. 1995; 56(11-12):931-8. PMID: 10188795.
    Citations: 20     Fields:    Translation:AnimalsCells
  121. Hersch S, Jones R, Koroshetz W, Quaid K. The neurogenetics genie: testing for the Huntington's disease mutation. Neurology. 1994 Aug; 44(8):1369-73. PMID: 7914682.
    Citations: 5     Fields:    Translation:Humans
  122. Hersch SM, Gutekunst CA, Rees HD, Heilman CJ, Levey AI. Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies. J Neurosci. 1994 May; 14(5 Pt 2):3351-63. PMID: 8182478; PMCID: PMC6577507.
    Citations: 149     Fields:    Translation:Animals
  123. Levey AI, Hersch SM, Rye DB, Sunahara RK, Niznik HB, Kitt CA, Price DL, Maggio R, Brann MR, Ciliax BJ. Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies. Proc Natl Acad Sci U S A. 1993 Oct 01; 90(19):8861-5. PMID: 8415621; PMCID: PMC47460.
    Citations: 183     Fields:    Translation:HumansCells
  124. Green RC, Goldstein FC, Auchus AP, Presley R, Clark WS, Van Tuyl L, Green J, Hersch SM, Karp HR. Treatment trial of oxiracetam in Alzheimer's disease. Arch Neurol. 1992 Nov; 49(11):1135-6. PMID: 1444879.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  125. Kamei S, Hersch SM, Kurata T, Takei Y. Coxsackie B antigen in the central nervous system of a patient with fatal acute encephalitis: immunohistochemical studies of formalin-fixed paraffin-embedded tissue. Acta Neuropathol. 1990; 80(2):216-21. PMID: 2167606.
    Citations: 10     Fields:    Translation:HumansCells
  126. Kamei S, Hersch SM, Takasu T, Takei Y. [Acquired immunodeficiency syndrome presenting with neurological symptoms]. Nihon Naika Gakkai Zasshi. 1989 Mar; 78(3):426-7. PMID: 2732602.
    Citations:    Fields:    Translation:Humans
  127. Cipolloni PB, Hersch SM, White EL. The use of lectin transport in the mouse central nervous system as an anterograde axonal marker for electron microscopy. Neurosci Lett. 1985 Jul 04; 58(1):43-7. PMID: 2995873.
    Citations: 4     Fields:    Translation:AnimalsCells
  128. White EL, Benshalom G, Hersch SM. Thalamocortical and other synapses involving nonspiny multipolar cells of mouse SmI cortex. J Comp Neurol. 1984 Nov 01; 229(3):311-20. PMID: 6501606.
    Citations: 9     Fields:    Translation:AnimalsCells
  129. Hersch SM, White EL. A quantitative study of the thalamocortical and other synapses in layer IV of pyramidal cells projecting from mouse SmI cortex to the caudate-putamen nucleus. J Comp Neurol. 1982 Nov 01; 211(3):217-25. PMID: 7174891.
    Citations: 11     Fields:    Translation:AnimalsCells
  130. White EL, Hersch SM. A quantitative study of thalamocortical and other synapses involving the apical dendrites of corticothalamic projection cells in mouse SmI cortex. J Neurocytol. 1982 Feb; 11(1):137-57. PMID: 6174701.
    Citations: 24     Fields:    Translation:AnimalsCells
  131. Hersch SM, White EL. Thalamocortical synapses with corticothalamic projection neurons in mouse SmI cortex: electron microscopic demonstration of a monosynaptic feedback loop. Neurosci Lett. 1981 Jul 17; 24(3):207-10. PMID: 6168974.
    Citations: 7     Fields:    Translation:AnimalsCells
  132. White EL, Hersch SM. Thalamocortical synapses of pyramidal cells which project from SmI to MsI cortex in the mouse. J Comp Neurol. 1981 May 01; 198(1):167-81. PMID: 7229139.
    Citations: 9     Fields:    Translation:AnimalsCells
  133. Hersch SM, White EL. Thalamocortical synapses involving identified neurons in mouse primary somatosensory cortex: a terminal degeneration and golgi/EM study. J Comp Neurol. 1981 Jan 10; 195(2):253-63. PMID: 6166640.
    Citations: 7     Fields:    Translation:AnimalsCells
  134. Hersch SM, White EL. Quantification of synapses formed with apical dendrites of Golgi-impregnated pyramidal cells: variability in thalamocortical inputs, but consistency in the ratios of asymmetrical to symmetrical synapses. Neuroscience. 1981; 6(6):1043-51. PMID: 7279213.
    Citations: 14     Fields:    Translation:AnimalsCells
  135. White EL, Hersch SM, Rock MP. Synaptic sequences in mouse SmI cortex involving pyramidal cells labeled by retrograde filling with horseradish peroxidase. Neurosci Lett. 1980 Sep; 19(2):149-54. PMID: 7052523.
    Citations: 2     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.