Harvard Catalyst Profiles

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Lucas Farnung, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Farnung L, Ochmann M, Garg G, Vos SM, Cramer P. Structure of a backtracked hexasomal intermediate of nucleosome transcription. Mol Cell. 2022 09 01; 82(17):3126-3134.e7. PMID: 35858621.
    Citations:    Fields:    
  2. Filipovski M, Soffers JHM, Vos SM, Farnung L. Structural basis of nucleosome retention during transcription elongation. Science. 2022 06 17; 376(6599):1313-1316. PMID: 35709268; PMCID: PMC9524584.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Farnung L, Vos SM. Assembly of RNA polymerase II transcription initiation complexes. Curr Opin Struct Biol. 2022 04; 73:102335. PMID: 35183822; PMCID: PMC9339144.
    Citations:    Fields:    Translation:AnimalsCells
  4. Žumer K, Maier KC, Farnung L, Jaeger MG, Rus P, Winter G, Cramer P. Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo. Mol Cell. 2021 08 05; 81(15):3096-3109.e8. PMID: 34146481.
    Citations: 4     Fields:    Translation:HumansCells
  5. Oberbeckmann E, Niebauer V, Watanabe S, Farnung L, Moldt M, Schmid A, Cramer P, Peterson CL, Eustermann S, Hopfner KP, Korber P. Ruler elements in chromatin remodelers set nucleosome array spacing and phasing. Nat Commun. 2021 05 28; 12(1):3232. PMID: 34050140; PMCID: PMC8163753.
    Citations: 6     Fields:    Translation:AnimalsCells
  6. Farnung L, Ochmann M, Engeholm M, Cramer P. Structural basis of nucleosome transcription mediated by Chd1 and FACT. Nat Struct Mol Biol. 2021 04; 28(4):382-387. PMID: 33846633; PMCID: PMC8046669.
    Citations: 13     Fields:    Translation:AnimalsCells
  7. Kokic G, Hillen HS, Tegunov D, Dienemann C, Seitz F, Schmitzova J, Farnung L, Siewert A, Höbartner C, Cramer P. Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun. 2021 01 12; 12(1):279. PMID: 33436624.
    Citations: 119     Fields:    Translation:Cells
  8. Farnung L, Ochmann M, Cramer P. Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations. Elife. 2020 06 16; 9. PMID: 32543371.
    Citations: 19     Fields:    Translation:AnimalsCells
  9. Vos SM, Farnung L, Linden A, Urlaub H, Cramer P. Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation. Nat Struct Mol Biol. 2020 07; 27(7):668-677. PMID: 32541898.
    Citations: 18     Fields:    Translation:HumansCells
  10. Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P. Structure of replicating SARS-CoV-2 polymerase. Nature. 2020 08; 584(7819):154-156. PMID: 32438371.
    Citations: 254     Fields:    Translation:Cells
  11. Wang H, Farnung L, Dienemann C, Cramer P. Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding. Nat Struct Mol Biol. 2020 01; 27(1):8-13. PMID: 31819277; PMCID: PMC6955156.
    Citations: 16     Fields:    Translation:HumansCells
  12. Farnung L, Vos SM, Cramer P. Structure of transcribing RNA polymerase II-nucleosome complex. Nat Commun. 2018 12 21; 9(1):5432. PMID: 30575770; PMCID: PMC6303367.
    Citations: 31     Fields:    Translation:AnimalsCells
  13. Zhu F, Farnung L, Kaasinen E, Sahu B, Yin Y, Wei B, Dodonova SO, Nitta KR, Morgunova E, Taipale M, Cramer P, Taipale J. The interaction landscape between transcription factors and the nucleosome. Nature. 2018 10; 562(7725):76-81. PMID: 30250250; PMCID: PMC6173309.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  14. Vos SM, Farnung L, Boehning M, Wigge C, Linden A, Urlaub H, Cramer P. Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature. 2018 08; 560(7720):607-612. PMID: 30135578.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  15. Vos SM, Farnung L, Urlaub H, Cramer P. Structure of paused transcription complex Pol II-DSIF-NELF. Nature. 2018 08; 560(7720):601-606. PMID: 30135580; PMCID: PMC6245578.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  16. Liu X, Farnung L, Wigge C, Cramer P. Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by a-amanitin. J Biol Chem. 2018 05 11; 293(19):7189-7194. PMID: 29550768.
    Citations: 7     Fields:    Translation:AnimalsCells
  17. Malvezzi S, Farnung L, Aloisi CMN, Angelov T, Cramer P, Sturla SJ. Mechanism of RNA polymerase II stalling by DNA alkylation. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):12172-12177. PMID: 29087308; PMCID: PMC5699039.
    Citations: 6     Fields:    Translation:HumansCells
  18. Farnung L, Vos SM, Wigge C, Cramer P. Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature. 2017 10 26; 550(7677):539-542. PMID: 29019976; PMCID: PMC5697743.
    Citations: 83     Fields:    Translation:AnimalsCells
  19. Fitz V, Shin J, Ehrlich C, Farnung L, Cramer P, Zaburdaev V, Grill SW. Nucleosomal arrangement affects single-molecule transcription dynamics. Proc Natl Acad Sci U S A. 2016 Nov 08; 113(45):12733-12738. PMID: 27791062; PMCID: PMC5111697.
    Citations: 5     Fields:    
  20. Bösken CA, Farnung L, Hintermair C, Merzel Schachter M, Vogel-Bachmayr K, Blazek D, Anand K, Fisher RP, Eick D, Geyer M. The structure and substrate specificity of human Cdk12/Cyclin K. Nat Commun. 2014 Mar 24; 5:3505. PMID: 24662513.
    Citations: 75     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.