Associate Professor of Computational Biology and Bioinformatics
Harvard T.H. Chan School of Public Health
Harvard School of Public Health
655 Huntington Ave
Boston MA 02115
2008 - 2010
Claudia Adams Barr Award
2010 - 2011
Career Incubator Award
We develop computational method to analyze and integrate various data-types. Our long-term goal is to characterize the structure and dynamics of gene regulatory networks in order to mechanistic insights into the maintenance of cell-type identity. We apply this knowledge to investigate the etiology of cancer and other diseases.
Current research topics involving new statistical methodologies include: 1) targeting mechanisms for epigenetic factors; 2) multi-level spatial organization of chromatin states; 3) gene regulatory network reconstruction; 4) single cell level gene expression;.
Application areas include: 1) role of epigenetics in cancer and other diseases. 2) cancer pathways and networks; 3) stem cells maintenance and cell differentiation
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