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Smita Gopinath, Ph.D.

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Biography
Stanford University, Stanford, CAPhD2013Microbiolgy & Immunology
Mount Holyoke College, South Hadley, MAB.A.2006Biology, English
Yale University, New Haven, CT2020Viral Host-Pathogenesis

Overview
We are interested in studying the interactions between the commensal microbiota, pathogens and the host immune response in the one place they must necessarily meet – the mucosa. Studying host-pathogen interactions at the mucosa allows us to exploit the Red Queen Hypothesis (co-evolving organisms locked in competition) as a discovery tool to identify novel pathways and mechanisms by which we resist or tolerate infections. We have multiple projects aimed at studying the mechanisms by which pathogens activate and evade the mucosal immune response and how these interactions are modulated by the microbiota. Our goal is to generate and test new ideas for vaccine and drug candidates to better protect people against infectious disease.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gopinath S, Lu P, Iwasaki A. Cutting Edge: The Use of Topical Aminoglycosides as an Effective Pull in "Prime and Pull" Vaccine Strategy. J Immunol. 2020 04 01; 204(7):1703-1707. PMID: 32122994.
    Citations: 3     Fields:    Translation:AnimalsCells
  2. Gopinath S, Kim MV, Rakib T, Wong PW, van Zandt M, Barry NA, Kaisho T, Goodman AL, Iwasaki A. Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner. Nat Microbiol. 2018 05; 3(5):611-621. PMID: 29632368.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  3. Chernyavskaya Y, Mudbhary R, Zhang C, Tokarz D, Jacob V, Gopinath S, Sun X, Wang S, Magnani E, Madakashira BP, Yoder JA, Hoshida Y, Sadler KC. Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. Development. 2017 08 15; 144(16):2925-2939. PMID: 28698226.
    Citations: 14     Fields:    Translation:AnimalsCells
  4. Shin H, Kumamoto Y, Gopinath S, Iwasaki A. CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2. Nat Commun. 2016 11 09; 7:13346. PMID: 27827367.
    Citations: 28     Fields:    Translation:AnimalsCells
  5. Gopinath S, Kumamoto Y, Iwasaki A. O-linked sugars sound the alarm. Nat Immunol. 2016 Feb; 17(2):119-20. PMID: 26784258.
    Citations:    Fields:    Translation:HumansAnimals
  6. Hotson AN, Gopinath S, Nicolau M, Khasanova A, Finck R, Monack D, Nolan GP. Coordinate actions of innate immune responses oppose those of the adaptive immune system during Salmonella infection of mice. Sci Signal. 2016 Jan 12; 9(410):ra4. PMID: 26758212.
    Citations: 7     Fields:    Translation:AnimalsCells
  7. Gopinath S, Iwasaki A. Cervicovaginal microbiota: simple is better. Immunity. 2015 May 19; 42(5):790-1. PMID: 25992855.
    Citations: 4     Fields:    Translation:HumansCells
  8. Gopinath S, Lichtman JS, Bouley DM, Elias JE, Monack DM. Role of disease-associated tolerance in infectious superspreaders. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15780-5. PMID: 25331868.
    Citations: 29     Fields:    Translation:AnimalsCells
  9. Ng KM, Ferreyra JA, Higginbottom SK, Lynch JB, Kashyap PC, Gopinath S, Naidu N, Choudhury B, Weimer BC, Monack DM, Sonnenburg JL. Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature. 2013 Oct 03; 502(7469):96-9. PMID: 23995682.
    Citations: 328     Fields:    Translation:AnimalsCells
  10. Gopinath S, Hotson A, Johns J, Nolan G, Monack D. The systemic immune state of super-shedder mice is characterized by a unique neutrophil-dependent blunting of TH1 responses. PLoS Pathog. 2013; 9(6):e1003408. PMID: 23754944.
    Citations: 14     Fields:    Translation:AnimalsCells
  11. Gomez JA, Wapinski OL, Yang YW, Bureau JF, Gopinath S, Monack DM, Chang HY, Brahic M, Kirkegaard K. The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-? locus. Cell. 2013 Feb 14; 152(4):743-54. PMID: 23415224.
    Citations: 271     Fields:    Translation:AnimalsCells
  12. Gopinath S, Carden S, Monack D. Shedding light on Salmonella carriers. Trends Microbiol. 2012 Jul; 20(7):320-7. PMID: 22591832.
    Citations: 44     Fields:    Translation:HumansCells
  13. Ruby T, McLaughlin L, Gopinath S, Monack D. Salmonella's long-term relationship with its host. FEMS Microbiol Rev. 2012 May; 36(3):600-15. PMID: 22335190.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  14. McLaughlin LM, Govoni GR, Gerke C, Gopinath S, Peng K, Laidlaw G, Chien YH, Jeong HW, Li Z, Brown MD, Sacks DB, Monack D. The Salmonella SPI2 effector SseI mediates long-term systemic infection by modulating host cell migration. PLoS Pathog. 2009 Nov; 5(11):e1000671. PMID: 19956712.
    Citations: 49     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.