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profileBruce Palmer Bean, Ph.D.

TitleRobert Winthrop Professor of Neurobiology
InstitutionHarvard Medical School
DepartmentNeurobiology
AddressHarvard Medical School
Neurobiology Rm 301
220 Longwood Ave
Boston MA 02115
Phone617/432-1139
Fax617/734-7557
vCardDownload vCard (login for email)

Collapse Research 
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
P01NS072040     (CLAPHAM, DAVID E.)Aug 1, 2011 - Jul 31, 2016
NIH/NINDS
TRP Channel Mediated Pain Circuitry
Role: Principal Investigator

R01NS064274     (BEAN, BRUCE P)May 1, 2009 - Apr 30, 2014
NIH/NINDS
Selective targeting of sodium channel blockers to pain-sensing neurons
Role: Principal Investigator

R01GM070774     (BEAN, BRUCE P)Apr 1, 2004 - Mar 31, 2009
NIH/NIGMS
Ion channels in suprachiasmatic nucleus neurons
Role: Principal Investigator

P01NS038312     (BEAN, BRUCE P)Dec 1, 1998 - Nov 30, 2004
NIH/NINDS
ACETYLCHOLINE MODULATION OF NEURONAL EXCITABILITY
Role: Principal Investigator

R01NS036855     (BEAN, BRUCE P)Jul 1, 1997 - Jan 31, 2019
NIH/NINDS
Voltage-Dependent Ion Channels Controlling Firing Patterns of Central Neurons
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Liu P, Blair NT, Bean BP. Action potential broadening in capsaicin-sensitive DRG neurons from frequency-dependent reduction of Kv3 current. J Neurosci. 2017 Sep 06. PMID: 28877968.
    View in: PubMed
  2. Yekkirala AS, Roberson DP, Bean BP, Woolf CJ. Breaking barriers to novel analgesic drug development. Nat Rev Drug Discov. 2017 Aug; 16(8):545-564. PMID: 28596533.
    View in: PubMed
  3. Gantz SC, Bean BP. Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling. Neuron. 2017 Mar 22; 93(6):1375-1387.e2. PMID: 28262417.
    View in: PubMed
  4. Jo S, Bean BP. Lacosamide Inhibition of Nav1.7 Voltage-Gated Sodium Channels: Slow Binding to Fast-Inactivated States. Mol Pharmacol. 2017 Apr; 91(4):277-286. PMID: 28119481.
    View in: PubMed
  5. Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R. Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels. Elife. 2016 Apr 13; 5. PMID: 27074662; PMCID: PMC4866826.
  6. Kimm T, Khaliq ZM, Bean BP. Differential Regulation of Action Potential Shape and Burst-Frequency Firing by BK and Kv2 Channels in Substantia Nigra Dopaminergic Neurons. J Neurosci. 2015 Dec 16; 35(50):16404-17. PMID: 26674866; PMCID: PMC4679822.
  7. Bean BP. Pore dilation reconsidered. Nat Neurosci. 2015 Nov; 18(11):1534-5. PMID: 26505561; PMCID: PMC4704107.
  8. Yamada-Hanff J, Bean BP. Activation of Ih and TTX-sensitive sodium current at subthreshold voltages during CA1 pyramidal neuron firing. J Neurophysiol. 2015 Oct; 114(4):2376-89. PMID: 26289465; PMCID: PMC4620139 [Available on 10/01/16].
  9. Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 2015 Jul 15; 87(2):341-54. PMID: 26119026; PMCID: PMC4506220 [Available on 07/15/16].
  10. Kimm T, Bean BP. Inhibition of A-type potassium current by the peptide toxin SNX-482. J Neurosci. 2014 Jul 09; 34(28):9182-9. PMID: 25009251; PMCID: PMC4087201.
  11. Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 2014 Apr 10; 7(1):1-11. PMID: 24703839; PMCID: PMC4023477.
  12. Liu PW, Bean BP. Kv2 channel regulation of action potential repolarization and firing patterns in superior cervical ganglion neurons and hippocampal CA1 pyramidal neurons. J Neurosci. 2014 Apr 02; 34(14):4991-5002. PMID: 24695716; PMCID: PMC3972724.
  13. Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block. Br J Pharmacol. 2014 Jan; 171(2):438-51. PMID: 24117225; PMCID: PMC3904263.
  14. Jo S, Bean BP. Sidedness of carbamazepine accessibility to voltage-gated sodium channels. Mol Pharmacol. 2014 Feb; 85(2):381-7. PMID: 24319110; PMCID: PMC3913360.
  15. Yamada-Hanff J, Bean BP. Persistent sodium current drives conditional pacemaking in CA1 pyramidal neurons under muscarinic stimulation. J Neurosci. 2013 Sep 18; 33(38):15011-21. PMID: 24048831; PMCID: PMC3776055.
  16. Roberson DP, Gudes S, Sprague JM, Patoski HA, Robson VK, Blasl F, Duan B, Oh SB, Bean BP, Ma Q, Binshtok AM, Woolf CJ. Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci. 2013 Jul; 16(7):910-8. PMID: 23685721; PMCID: PMC3695070.
  17. Puopolo M, Binshtok AM, Yao GL, Oh SB, Woolf CJ, Bean BP. Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314. J Neurophysiol. 2013 Apr; 109(7):1704-12. PMID: 23303863; PMCID: PMC3628012.
  18. Brenneis C, Kistner K, Puopolo M, Segal D, Roberson D, Sisignano M, Labocha S, Ferreirós N, Strominger A, Cobos EJ, Ghasemlou N, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing. J Neurosci. 2013 Jan 02; 33(1):315-26. PMID: 23283344; PMCID: PMC3640269.
  19. Carter BC, Giessel AJ, Sabatini BL, Bean BP. Transient sodium current at subthreshold voltages: activation by EPSP waveforms. Neuron. 2012 Sep 20; 75(6):1081-93. PMID: 22998875; PMCID: PMC3460524.
  20. Liu P, Jo S, Bean BP. Modulation of neuronal sodium channels by the sea anemone peptide BDS-I. J Neurophysiol. 2012 Jun; 107(11):3155-67. PMID: 22442564; PMCID: PMC3378363.
  21. Roberson DP, Binshtok AM, Blasl F, Bean BP, Woolf CJ. Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review. Br J Pharmacol. 2011 Sep; 164(1):48-58. PMID: 21457220; PMCID: PMC3171859.
  22. Bosmans F, Puopolo M, Martin-Eauclaire MF, Bean BP, Swartz KJ. Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors. J Gen Physiol. 2011 Jul; 138(1):59-72. PMID: 21670206; PMCID: PMC3135324.
  23. Jo S, Bean BP. Inhibition of neuronal voltage-gated sodium channels by brilliant blue G. Mol Pharmacol. 2011 Aug; 80(2):247-57. PMID: 21536754; PMCID: PMC3141889.
  24. Carter BC, Bean BP. Incomplete inactivation and rapid recovery of voltage-dependent sodium channels during high-frequency firing in cerebellar Purkinje neurons. J Neurophysiol. 2011 Feb; 105(2):860-71. PMID: 21160003; PMCID: PMC3059179.
  25. Milescu LS, Bean BP, Smith JC. Isolation of somatic Na+ currents by selective inactivation of axonal channels with a voltage prepulse. J Neurosci. 2010 Jun 02; 30(22):7740-8. PMID: 20519549; PMCID: PMC2913474.
  26. Khaliq ZM, Bean BP. Pacemaking in dopaminergic ventral tegmental area neurons: depolarizing drive from background and voltage-dependent sodium conductances. J Neurosci. 2010 May 26; 30(21):7401-13. PMID: 20505107; PMCID: PMC2892804.
  27. Kim HY, Kim K, Li HY, Chung G, Park CK, Kim JS, Jung SJ, Lee MK, Ahn DK, Hwang SJ, Kang Y, Binshtok AM, Bean BP, Woolf CJ, Oh SB. Selectively targeting pain in the trigeminal system. Pain. 2010 Jul; 150(1):29-40. PMID: 20236764; PMCID: PMC4704110.
  28. Cannon SC, Bean BP. Sodium channels gone wild: resurgent current from neuronal and muscle channelopathies. J Clin Invest. 2010 Jan; 120(1):80-3. PMID: 20038809; PMCID: PMC2798702.
  29. Carter BC, Bean BP. Sodium entry during action potentials of mammalian neurons: incomplete inactivation and reduced metabolic efficiency in fast-spiking neurons. Neuron. 2009 Dec 24; 64(6):898-909. PMID: 20064395; PMCID: PMC2810867.
  30. Binshtok AM, Gerner P, Oh SB, Puopolo M, Suzuki S, Roberson DP, Herbert T, Wang CF, Kim D, Chung G, Mitani AA, Wang GK, Bean BP, Woolf CJ. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology. 2009 Jul; 111(1):127-37. PMID: 19512868; PMCID: PMC2761747.
  31. Bean BP. Inhibition by an excitatory conductance: a paradox explained. Nat Neurosci. 2009 May; 12(5):530-2. PMID: 19396231.
    View in: PubMed
  32. Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, Brenner GJ, Ji RR, Bean BP, Woolf CJ, Samad TA. Nociceptors are interleukin-1beta sensors. J Neurosci. 2008 Dec 24; 28(52):14062-73. PMID: 19109489; PMCID: PMC2690713.
  33. Gerner P, Binshtok AM, Wang CF, Hevelone ND, Bean BP, Woolf CJ, Wang GK. Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve. Anesthesiology. 2008 Nov; 109(5):872-8. PMID: 18946300; PMCID: PMC2635105.
  34. Khaliq ZM, Bean BP. Dynamic, nonlinear feedback regulation of slow pacemaking by A-type potassium current in ventral tegmental area neurons. J Neurosci. 2008 Oct 22; 28(43):10905-17. PMID: 18945898; PMCID: PMC2837275.
  35. Binshtok AM, Bean BP, Woolf CJ. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature. 2007 Oct 04; 449(7162):607-10. PMID: 17914397.
    View in: PubMed
  36. Jackson AC, Bean BP. State-dependent enhancement of subthreshold A-type potassium current by 4-aminopyridine in tuberomammillary nucleus neurons. J Neurosci. 2007 Oct 03; 27(40):10785-96. PMID: 17913912.
    View in: PubMed
  37. Bean BP. Neurophysiology: stressful pacemaking. Nature. 2007 Jun 28; 447(7148):1059-60. PMID: 17597746.
    View in: PubMed
  38. Bean BP. The action potential in mammalian central neurons. Nat Rev Neurosci. 2007 Jun; 8(6):451-65. PMID: 17514198.
    View in: PubMed
  39. Puopolo M, Raviola E, Bean BP. Roles of subthreshold calcium current and sodium current in spontaneous firing of mouse midbrain dopamine neurons. J Neurosci. 2007 Jan 17; 27(3):645-56. PMID: 17234596.
    View in: PubMed
  40. Martina M, Metz AE, Bean BP. Voltage-dependent potassium currents during fast spikes of rat cerebellar Purkinje neurons: inhibition by BDS-I toxin. J Neurophysiol. 2007 Jan; 97(1):563-71. PMID: 17065256.
    View in: PubMed
  41. Puopolo M, Bean BP, Raviola E. Spontaneous activity of isolated dopaminergic periglomerular cells of the main olfactory bulb. J Neurophysiol. 2005 Nov; 94(5):3618-27. PMID: 16033943.
    View in: PubMed
  42. Swensen AM, Bean BP. Robustness of burst firing in dissociated purkinje neurons with acute or long-term reductions in sodium conductance. J Neurosci. 2005 Apr 06; 25(14):3509-20. PMID: 15814781.
    View in: PubMed
  43. Bean BP. The molecular machinery of resurgent sodium current revealed. Neuron. 2005 Jan 20; 45(2):185-7. PMID: 15664169.
    View in: PubMed
  44. McDonough SI, Mori Y, Bean BP. FPL 64176 modification of Ca(V)1.2 L-type calcium channels: dissociation of effects on ionic current and gating current. Biophys J. 2005 Jan; 88(1):211-23. PMID: 15501945; PMCID: PMC1304999.
  45. Jackson AC, Yao GL, Bean BP. Mechanism of spontaneous firing in dorsomedial suprachiasmatic nucleus neurons. J Neurosci. 2004 Sep 15; 24(37):7985-98. PMID: 15371499.
    View in: PubMed
  46. Do MT, Bean BP. Sodium currents in subthalamic nucleus neurons from Nav1.6-null mice. J Neurophysiol. 2004 Aug; 92(2):726-33. PMID: 15056687.
    View in: PubMed
  47. Blair NT, Bean BP. Role of tetrodotoxin-resistant Na+ current slow inactivation in adaptation of action potential firing in small-diameter dorsal root ganglion neurons. J Neurosci. 2003 Nov 12; 23(32):10338-50. PMID: 14614093.
    View in: PubMed
  48. Swensen AM, Bean BP. Ionic mechanisms of burst firing in dissociated Purkinje neurons. J Neurosci. 2003 Oct 22; 23(29):9650-63. PMID: 14573545.
    View in: PubMed
  49. Do MT, Bean BP. Subthreshold sodium currents and pacemaking of subthalamic neurons: modulation by slow inactivation. Neuron. 2003 Jul 03; 39(1):109-20. PMID: 12848936.
    View in: PubMed
  50. Martina M, Yao GL, Bean BP. Properties and functional role of voltage-dependent potassium channels in dendrites of rat cerebellar Purkinje neurons. J Neurosci. 2003 Jul 02; 23(13):5698-707. PMID: 12843273.
    View in: PubMed
  51. Mitterdorfer J, Bean BP. Potassium currents during the action potential of hippocampal CA3 neurons. J Neurosci. 2002 Dec 01; 22(23):10106-15. PMID: 12451111.
    View in: PubMed
  52. Blair NT, Bean BP. Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons. J Neurosci. 2002 Dec 01; 22(23):10277-90. PMID: 12451128.
    View in: PubMed
  53. McDonough SI, Boland LM, Mintz IM, Bean BP. Interactions among toxins that inhibit N-type and P-type calcium channels. J Gen Physiol. 2002 Apr; 119(4):313-28. PMID: 11929883; PMCID: PMC2311392.
  54. Taddese A, Bean BP. Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron. 2002 Feb 14; 33(4):587-600. PMID: 11856532.
    View in: PubMed
  55. Raman IM, Bean BP. Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms. Biophys J. 2001 Feb; 80(2):729-37. PMID: 11159440; PMCID: PMC1301271.
  56. Bean BP. Modulating modulation. J Gen Physiol. 2000 Mar; 115(3):273-5. PMID: 10694256; PMCID: PMC2217206.
  57. Greif GJ, Sodickson DL, Bean BP, Neer EJ, Mende U. Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking Galpha(o). J Neurophysiol. 2000 Feb; 83(2):1010-8. PMID: 10669512.
    View in: PubMed
  58. Raman IM, Bean BP. Properties of sodium currents and action potential firing in isolated cerebellar Purkinje neurons. Ann N Y Acad Sci. 1999 Apr 30; 868:93-6. PMID: 10414287.
    View in: PubMed
  59. Burgess DL, Biddlecome GH, McDonough SI, Diaz ME, Zilinski CA, Bean BP, Campbell KP, Noebels JL. beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain. Mol Cell Neurosci. 1999 Apr; 13(4):293-311. PMID: 10328888.
    View in: PubMed
  60. Raman IM, Bean BP. Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons. J Neurosci. 1999 Mar 01; 19(5):1663-74. PMID: 10024353.
    View in: PubMed
  61. McDonough SI, Bean BP. Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons. Mol Pharmacol. 1998 Dec; 54(6):1080-7. PMID: 9855637.
    View in: PubMed
  62. Sodickson DL, Bean BP. Neurotransmitter activation of inwardly rectifying potassium current in dissociated hippocampal CA3 neurons: interactions among multiple receptors. J Neurosci. 1998 Oct 15; 18(20):8153-62. PMID: 9763462.
    View in: PubMed
  63. Feigenspan A, Gustincich S, Bean BP, Raviola E. Spontaneous activity of solitary dopaminergic cells of the retina. J Neurosci. 1998 Sep 01; 18(17):6776-89. PMID: 9712649.
    View in: PubMed
  64. Bean BP, McDonough SI. Two for T. Neuron. 1998 May; 20(5):825-8. PMID: 9620687.
    View in: PubMed
  65. McDonough SI, Lampe RA, Keith RA, Bean BP. Voltage-dependent inhibition of N- and P-type calcium channels by the peptide toxin omega-grammotoxin-SIA. Mol Pharmacol. 1997 Dec; 52(6):1095-104. PMID: 9415720.
    View in: PubMed
  66. Raman IM, Sprunger LK, Meisler MH, Bean BP. Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron. 1997 Oct; 19(4):881-91. PMID: 9354334.
    View in: PubMed
  67. Raman IM, Bean BP. Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons. J Neurosci. 1997 Jun 15; 17(12):4517-26. PMID: 9169512.
    View in: PubMed
  68. McDonough SI, Mintz IM, Bean BP. Alteration of P-type calcium channel gating by the spider toxin omega-Aga-IVA. Biophys J. 1997 May; 72(5):2117-28. PMID: 9129813; PMCID: PMC1184405.
  69. Sodickson DL, Bean BP. GABAB receptor-activated inwardly rectifying potassium current in dissociated hippocampal CA3 neurons. J Neurosci. 1996 Oct 15; 16(20):6374-85. PMID: 8815916.
    View in: PubMed
  70. McDonough SI, Swartz KJ, Mintz IM, Boland LM, Bean BP. Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIIC. J Neurosci. 1996 Apr 15; 16(8):2612-23. PMID: 8786437.
    View in: PubMed
  71. Cardozo DL, Bean BP. Voltage-dependent calcium channels in rat midbrain dopamine neurons: modulation by dopamine and GABAB receptors. J Neurophysiol. 1995 Sep; 74(3):1137-48. PMID: 7500139.
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  72. Kuo CC, Bean BP. Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons. Mol Pharmacol. 1994 Oct; 46(4):716-25. PMID: 7969051.
    View in: PubMed
  73. Boland LM, Morrill JA, Bean BP. omega-Conotoxin block of N-type calcium channels in frog and rat sympathetic neurons. J Neurosci. 1994 Aug; 14(8):5011-27. PMID: 8046465.
    View in: PubMed
  74. Kuo CC, Bean BP. Na+ channels must deactivate to recover from inactivation. Neuron. 1994 Apr; 12(4):819-29. PMID: 8161454.
    View in: PubMed
  75. Bean B. Taking the beta test. Nature. 1994 Mar 03; 368(6466):15-6. PMID: 8107877.
    View in: PubMed
  76. Sah DW, Bean BP. Inhibition of P-type and N-type calcium channels by dopamine receptor antagonists. Mol Pharmacol. 1994 Jan; 45(1):84-92. PMID: 8302284.
    View in: PubMed
  77. Mintz IM, Bean BP. Block of calcium channels in rat neurons by synthetic omega-Aga-IVA. Neuropharmacology. 1993 Nov; 32(11):1161-9. PMID: 8107970.
    View in: PubMed
  78. Adams ME, Mintz IM, Reily MD, Thanabal V, Bean BP. Structure and properties of omega-agatoxin IVB, a new antagonist of P-type calcium channels. Mol Pharmacol. 1993 Oct; 44(4):681-8. PMID: 8232218.
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  79. Kuo CC, Bean BP. G-protein modulation of ion permeation through N-type calcium channels. Nature. 1993 Sep 16; 365(6443):258-62. PMID: 8396731.
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  80. Mintz IM, Bean BP. GABAB receptor inhibition of P-type Ca2+ channels in central neurons. Neuron. 1993 May; 10(5):889-98. PMID: 8388225.
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  81. Boland LM, Bean BP. Modulation of N-type calcium channels in bullfrog sympathetic neurons by luteinizing hormone-releasing hormone: kinetics and voltage dependence. J Neurosci. 1993 Feb; 13(2):516-33. PMID: 7678856.
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  82. Swartz KJ, Merritt A, Bean BP, Lovinger DM. Protein kinase C modulates glutamate receptor inhibition of Ca2+ channels and synaptic transmission. Nature. 1993 Jan 14; 361(6408):165-8. PMID: 8380626.
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  83. Swartz KJ, Bean BP. Inhibition of calcium channels in rat CA3 pyramidal neurons by a metabotropic glutamate receptor. J Neurosci. 1992 Nov; 12(11):4358-71. PMID: 1359036.
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  84. Hillyard DR, Monje VD, Mintz IM, Bean BP, Nadasdi L, Ramachandran J, Miljanich G, Azimi-Zoonooz A, McIntosh JM, Cruz LJ, et al. A new Conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron. 1992 Jul; 9(1):69-77. PMID: 1352986.
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  85. Mintz IM, Adams ME, Bean BP. P-type calcium channels in rat central and peripheral neurons. Neuron. 1992 Jul; 9(1):85-95. PMID: 1321648.
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  86. Bean BP. Pharmacology and electrophysiology of ATP-activated ion channels. Trends Pharmacol Sci. 1992 Mar; 13(3):87-90. PMID: 1374198.
    View in: PubMed
  87. Mintz IM, Venema VJ, Swiderek KM, Lee TD, Bean BP, Adams ME. P-type calcium channels blocked by the spider toxin omega-Aga-IVA. Nature. 1992 Feb 27; 355(6363):827-9. PMID: 1311418.
    View in: PubMed
  88. Bean BP. Whole-cell recording of calcium channel currents. Methods Enzymol. 1992; 207:181-93. PMID: 1326702.
    View in: PubMed
  89. Mintz IM, Venema VJ, Adams ME, Bean BP. Inhibition of N- and L-type Ca2+ channels by the spider venom toxin omega-Aga-IIIA. Proc Natl Acad Sci U S A. 1991 Aug 01; 88(15):6628-31. PMID: 1713686; PMCID: PMC52141.
  90. Bean BP. Pharmacology of calcium channels in cardiac muscle, vascular muscle, and neurons. Am J Hypertens. 1991 Jul; 4(7 Pt 2):406S-411S. PMID: 1654934.
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  91. Regan LJ, Sah DW, Bean BP. Ca2+ channels in rat central and peripheral neurons: high-threshold current resistant to dihydropyridine blockers and omega-conotoxin. Neuron. 1991 Feb; 6(2):269-80. PMID: 1847065.
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  92. Bean B. Calcium channels. Gating for the physiologist. Nature. 1990 Nov 15; 348(6298):192-3. PMID: 1978254.
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  93. Friel DD, Bean BP. Dual control by ATP and acetylcholine of inwardly rectifying K+ channels in bovine atrial cells. Pflugers Arch. 1990 Mar; 415(6):651-7. PMID: 2336344.
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  94. Bean BP, Friel DD. ATP-activated channels in excitable cells. Ion Channels. 1990; 2:169-203. PMID: 1715204.
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  95. Bean BP. ATP-activated channels in rat and bullfrog sensory neurons: concentration dependence and kinetics. J Neurosci. 1990 Jan; 10(1):1-10. PMID: 1688928.
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  96. Bean BP, Williams CA, Ceelen PW. ATP-activated channels in rat and bullfrog sensory neurons: current-voltage relation and single-channel behavior. J Neurosci. 1990 Jan; 10(1):11-9. PMID: 1688930.
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  97. Bean BP. Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature. 1989 Jul 13; 340(6229):153-6. PMID: 2567963.
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  98. Bean BP, Rios E. Nonlinear charge movement in mammalian cardiac ventricular cells. Components from Na and Ca channel gating. J Gen Physiol. 1989 Jul; 94(1):65-93. PMID: 2553859; PMCID: PMC2228930.
  99. Bean B. More than a Ca2+ channel? Trends Neurosci. 1989 Apr; 12(4):128-30. PMID: 2470169.
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  100. Bean BP. Classes of calcium channels in vertebrate cells. Annu Rev Physiol. 1989; 51:367-84. PMID: 2540697.
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  101. Bean BP. Multiple types of calcium channels in heart muscle and neurons. Modulation by drugs and neurotransmitters. Ann N Y Acad Sci. 1989; 560:334-45. PMID: 2568109.
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  102. Huettner JE, Bean BP. Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc Natl Acad Sci U S A. 1988 Feb; 85(4):1307-11. PMID: 2448800; PMCID: PMC279756.
  103. Friel DD, Bean BP. Two ATP-activated conductances in bullfrog atrial cells. J Gen Physiol. 1988 Jan; 91(1):1-27. PMID: 3257791; PMCID: PMC2216125.
  104. Triggle DJ, Lazdunski M, Bean BP. [Calcium channels and calcium antagonists]. Med Monatsschr Pharm. 1986 Dec; 9(12):363-4. PMID: 2433568.
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  105. Bean BP, Sturek M, Puga A, Hermsmeyer K. Calcium channels in muscle cells isolated from rat mesenteric arteries: modulation by dihydropyridine drugs. Circ Res. 1986 Aug; 59(2):229-35. PMID: 2427250.
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  106. Tsien RW, Bean BP, Hess P, Lansman JB, Nilius B, Nowycky MC. Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists. J Mol Cell Cardiol. 1986 Jul; 18(7):691-710. PMID: 2427730.
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  107. Bean BP. Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology. J Gen Physiol. 1985 Jul; 86(1):1-30. PMID: 2411846; PMCID: PMC2228774.
  108. Bean BP. Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc Natl Acad Sci U S A. 1984 Oct; 81(20):6388-92. PMID: 6093100; PMCID: PMC391929.
  109. Cohen CJ, Bean BP, Tsien RW. Maximal upstroke velocity as an index of available sodium conductance. Comparison of maximal upstroke velocity and voltage clamp measurements of sodium current in rabbit Purkinje fibers. Circ Res. 1984 Jun; 54(6):636-51. PMID: 6329543.
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  110. Bean BP, Nowycky MC, Tsien RW. Beta-adrenergic modulation of calcium channels in frog ventricular heart cells. Nature. 1984 Jan 26-Feb 1; 307(5949):371-5. PMID: 6320002.
    View in: PubMed
  111. Bean BP, Cohen CJ, Tsien RW. Lidocaine block of cardiac sodium channels. J Gen Physiol. 1983 May; 81(5):613-42. PMID: 6306139; PMCID: PMC2216565.
  112. Tsien RW, Bean BP, Hess P, Nowycky M. Calcium channels: mechanisms of beta-adrenergic modulation and ion permeation. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:201-12. PMID: 6327154.
    View in: PubMed
  113. Cohen CJ, Bean BP, Colatsky TJ, Tsien RW. Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating. J Gen Physiol. 1981 Oct; 78(4):383-411. PMID: 6270235; PMCID: PMC2228621.
  114. Bean BP. Sodium channel inactivation in the crayfish giant axon. Must channels open before inactivating? Biophys J. 1981 Sep; 35(3):595-614. PMID: 6268217; PMCID: PMC1327551.
  115. Bean BP, Shrager P, Goldstein DA. Modification of sodium and potassium channel gating kinetics by ether and halothane. J Gen Physiol. 1981 Mar; 77(3):233-53. PMID: 6265590; PMCID: PMC2215432.
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