Harvard Catalyst Profiles

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Bruce Palmer Bean, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS110860 (BEAN, BRUCE P) Feb 1, 2019 - Jan 31, 2024
    State-dependent interaction of antiepileptic drugs with voltage-dependent sodium channels and differential regulation of excitatory and inhibitory central neurons
    Role: Principal Investigator
  2. P01NS072040 (CLAPHAM, DAVID E.) Aug 1, 2011 - May 31, 2017
    TRP Channel Mediated Pain Circuitry
    Role: Principal Investigator
  3. R01NS064274 (BEAN, BRUCE P) May 1, 2009 - Apr 30, 2014
    Selective targeting of sodium channel blockers to pain-sensing neurons
    Role: Principal Investigator
  4. R01GM070774 (BEAN, BRUCE P) Apr 1, 2004 - Mar 31, 2009
    Ion channels in suprachiasmatic nucleus neurons
    Role: Principal Investigator
  5. P01NS038312 (BEAN, BRUCE P) Dec 1, 1998 - Nov 30, 2004
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhang HB, Bean BP. Cannabidiol inhibition of murine primary nociceptors: Tight binding to slow inactivated states of Nav1.8 channels. J Neurosci. 2021 Jun 15. PMID: 34131037.
    Citations:    Fields:    
  2. Tochitsky I, Jo S, Andrews N, Kotoda M, Doyle B, Shim J, Talbot S, Roberson D, Lee J, Haste L, Jordan SM, Levy BD, Bean BP, Woolf CJ. Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker. Br J Pharmacol. 2021 May 14. PMID: 33988876.
    Citations:    Fields:    
  3. Niday Z, Bean BP. BK Channel Regulation of Afterpotentials and Burst Firing in Cerebellar Purkinje Neurons. J Neurosci. 2021 Mar 31; 41(13):2854-2869. PMID: 33593855.
    Citations:    Fields:    
  4. Jo S, Bean BP. Lidocaine Binding Enhances Inhibition of Nav1.7 Channels by the Sulfonamide PF-05089771. Mol Pharmacol. 2020 06; 97(6):377-383. PMID: 32193331.
    Citations:    Fields:    Translation:HumansCells
  5. Talbot S, Doyle B, Huang J, Wang JC, Ahmadi M, Roberson DP, Yekkirala A, Foster SL, Browne LE, Bean BP, Levy BD, Woolf CJ. Vagal sensory neurons drive mucous cell metaplasia. J Allergy Clin Immunol. 2020 06; 145(6):1693-1696.e4. PMID: 31954778.
    Citations: 4     Fields:    Translation:AnimalsCells
  6. Lee S, Jo S, Talbot S, Zhang HB, Kotoda M, Andrews NA, Puopolo M, Liu PW, Jacquemont T, Pascal M, Heckman LM, Jain A, Lee J, Woolf CJ, Bean BP. Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation. Elife. 2019 11 25; 8. PMID: 31765298.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Zheng Y, Liu P, Bai L, Trimmer JS, Bean BP, Ginty DD. Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties. Neuron. 2019 08 21; 103(4):598-616.e7. PMID: 31248728.
    Citations: 33     Fields:    Translation:AnimalsCells
  8. Weyrer C, Turecek J, Niday Z, Liu PW, Nanou E, Catterall WA, Bean BP, Regehr WG. The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation. Cell Rep. 2019 02 26; 26(9):2289-2297.e3. PMID: 30811980.
    Citations: 5     Fields:    Translation:AnimalsCells
  9. Hu W, Bean BP. Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons. Neuron. 2018 Sep 19; 99(6):1355. PMID: 30236286.
    Citations: 4     Fields:    
  10. Hu W, Bean BP. Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons. Neuron. 2018 03 21; 97(6):1315-1326.e3. PMID: 29526554.
    Citations: 15     Fields:    Translation:AnimalsCells
  11. Yekkirala AS, Roberson DP, Bean BP, Woolf CJ. Breaking barriers to novel analgesic drug development. Nat Rev Drug Discov. 2017 11; 16(11):810. PMID: 28983099.
    Citations: 14     Fields:    
  12. Liu PW, Blair NT, Bean BP. Action Potential Broadening in Capsaicin-Sensitive DRG Neurons from Frequency-Dependent Reduction of Kv3 Current. J Neurosci. 2017 10 04; 37(40):9705-9714. PMID: 28877968.
    Citations: 13     Fields:    Translation:AnimalsCells
  13. Yekkirala AS, Roberson DP, Bean BP, Woolf CJ. Breaking barriers to novel analgesic drug development. Nat Rev Drug Discov. 2017 Aug; 16(8):545-564. PMID: 28596533.
    Citations: 50     Fields:    Translation:HumansAnimals
  14. Gantz SC, Bean BP. Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling. Neuron. 2017 Mar 22; 93(6):1375-1387.e2. PMID: 28262417.
    Citations: 18     Fields:    Translation:AnimalsCells
  15. Jo S, Bean BP. Lacosamide Inhibition of Nav1.7 Voltage-Gated Sodium Channels: Slow Binding to Fast-Inactivated States. Mol Pharmacol. 2017 04; 91(4):277-286. PMID: 28119481.
    Citations: 6     Fields:    Translation:HumansCells
  16. Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R. Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels. Elife. 2016 04 13; 5. PMID: 27074662.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  17. Kimm T, Khaliq ZM, Bean BP. Differential Regulation of Action Potential Shape and Burst-Frequency Firing by BK and Kv2 Channels in Substantia Nigra Dopaminergic Neurons. J Neurosci. 2015 Dec 16; 35(50):16404-17. PMID: 26674866.
    Citations: 30     Fields:    Translation:AnimalsCells
  18. Bean BP. Pore dilation reconsidered. Nat Neurosci. 2015 Nov; 18(11):1534-5. PMID: 26505561.
    Citations: 5     Fields:    Translation:HumansCells
  19. Yamada-Hanff J, Bean BP. Activation of Ih and TTX-sensitive sodium current at subthreshold voltages during CA1 pyramidal neuron firing. J Neurophysiol. 2015 Oct; 114(4):2376-89. PMID: 26289465.
    Citations: 12     Fields:    Translation:AnimalsCells
  20. Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 2015 Jul 15; 87(2):341-54. PMID: 26119026.
    Citations: 96     Fields:    Translation:AnimalsCells
  21. Kimm T, Bean BP. Inhibition of A-type potassium current by the peptide toxin SNX-482. J Neurosci. 2014 Jul 09; 34(28):9182-9. PMID: 25009251.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  22. Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 2014 Apr 10; 7(1):1-11. PMID: 24703839.
    Citations: 216     Fields:    Translation:HumansCells
  23. Liu PW, Bean BP. Kv2 channel regulation of action potential repolarization and firing patterns in superior cervical ganglion neurons and hippocampal CA1 pyramidal neurons. J Neurosci. 2014 Apr 02; 34(14):4991-5002. PMID: 24695716.
    Citations: 50     Fields:    Translation:AnimalsCells
  24. Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block. Br J Pharmacol. 2014 Jan; 171(2):438-51. PMID: 24117225.
    Citations: 17     Fields:    Translation:AnimalsCells
  25. Jo S, Bean BP. Sidedness of carbamazepine accessibility to voltage-gated sodium channels. Mol Pharmacol. 2014 Feb; 85(2):381-7. PMID: 24319110.
    Citations: 8     Fields:    Translation:HumansCells
  26. Yamada-Hanff J, Bean BP. Persistent sodium current drives conditional pacemaking in CA1 pyramidal neurons under muscarinic stimulation. J Neurosci. 2013 Sep 18; 33(38):15011-21. PMID: 24048831.
    Citations: 33     Fields:    Translation:AnimalsCells
  27. Roberson DP, Gudes S, Sprague JM, Patoski HA, Robson VK, Blasl F, Duan B, Oh SB, Bean BP, Ma Q, Binshtok AM, Woolf CJ. Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci. 2013 Jul; 16(7):910-8. PMID: 23685721.
    Citations: 55     Fields:    Translation:AnimalsCells
  28. Puopolo M, Binshtok AM, Yao GL, Oh SB, Woolf CJ, Bean BP. Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314. J Neurophysiol. 2013 Apr; 109(7):1704-12. PMID: 23303863.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  29. Brenneis C, Kistner K, Puopolo M, Segal D, Roberson D, Sisignano M, Labocha S, Ferreirós N, Strominger A, Cobos EJ, Ghasemlou N, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing. J Neurosci. 2013 Jan 02; 33(1):315-26. PMID: 23283344.
    Citations: 34     Fields:    Translation:AnimalsCells
  30. Carter BC, Giessel AJ, Sabatini BL, Bean BP. Transient sodium current at subthreshold voltages: activation by EPSP waveforms. Neuron. 2012 Sep 20; 75(6):1081-93. PMID: 22998875.
    Citations: 41     Fields:    Translation:AnimalsCells
  31. Liu P, Jo S, Bean BP. Modulation of neuronal sodium channels by the sea anemone peptide BDS-I. J Neurophysiol. 2012 Jun; 107(11):3155-67. PMID: 22442564.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  32. Roberson DP, Binshtok AM, Blasl F, Bean BP, Woolf CJ. Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review. Br J Pharmacol. 2011 Sep; 164(1):48-58. PMID: 21457220.
    Citations: 25     Fields:    Translation:AnimalsCells
  33. Bosmans F, Puopolo M, Martin-Eauclaire MF, Bean BP, Swartz KJ. Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors. J Gen Physiol. 2011 Jul; 138(1):59-72. PMID: 21670206.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  34. Jo S, Bean BP. Inhibition of neuronal voltage-gated sodium channels by brilliant blue G. Mol Pharmacol. 2011 Aug; 80(2):247-57. PMID: 21536754.
    Citations: 34     Fields:    Translation:AnimalsCells
  35. Carter BC, Bean BP. Incomplete inactivation and rapid recovery of voltage-dependent sodium channels during high-frequency firing in cerebellar Purkinje neurons. J Neurophysiol. 2011 Feb; 105(2):860-71. PMID: 21160003.
    Citations: 22     Fields:    Translation:AnimalsCells
  36. Milescu LS, Bean BP, Smith JC. Isolation of somatic Na+ currents by selective inactivation of axonal channels with a voltage prepulse. J Neurosci. 2010 Jun 02; 30(22):7740-8. PMID: 20519549.
    Citations: 22     Fields:    Translation:AnimalsCells
  37. Khaliq ZM, Bean BP. Pacemaking in dopaminergic ventral tegmental area neurons: depolarizing drive from background and voltage-dependent sodium conductances. J Neurosci. 2010 May 26; 30(21):7401-13. PMID: 20505107.
    Citations: 111     Fields:    Translation:AnimalsCells
  38. Kim HY, Kim K, Li HY, Chung G, Park CK, Kim JS, Jung SJ, Lee MK, Ahn DK, Hwang SJ, Kang Y, Binshtok AM, Bean BP, Woolf CJ, Oh SB. Selectively targeting pain in the trigeminal system. Pain. 2010 Jul; 150(1):29-40. PMID: 20236764.
    Citations: 19     Fields:    Translation:AnimalsCells
  39. Cannon SC, Bean BP. Sodium channels gone wild: resurgent current from neuronal and muscle channelopathies. J Clin Invest. 2010 Jan; 120(1):80-3. PMID: 20038809.
    Citations: 8     Fields:    Translation:HumansCells
  40. Carter BC, Bean BP. Sodium entry during action potentials of mammalian neurons: incomplete inactivation and reduced metabolic efficiency in fast-spiking neurons. Neuron. 2009 Dec 24; 64(6):898-909. PMID: 20064395.
    Citations: 90     Fields:    Translation:AnimalsCells
  41. Binshtok AM, Gerner P, Oh SB, Puopolo M, Suzuki S, Roberson DP, Herbert T, Wang CF, Kim D, Chung G, Mitani AA, Wang GK, Bean BP, Woolf CJ. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology. 2009 Jul; 111(1):127-37. PMID: 19512868.
    Citations: 37     Fields:    Translation:AnimalsCells
  42. Bean BP. Inhibition by an excitatory conductance: a paradox explained. Nat Neurosci. 2009 May; 12(5):530-2. PMID: 19396231.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  43. Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, Brenner GJ, Ji RR, Bean BP, Woolf CJ, Samad TA. Nociceptors are interleukin-1beta sensors. J Neurosci. 2008 Dec 24; 28(52):14062-73. PMID: 19109489.
    Citations: 203     Fields:    Translation:AnimalsCells
  44. Gerner P, Binshtok AM, Wang CF, Hevelone ND, Bean BP, Woolf CJ, Wang GK. Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve. Anesthesiology. 2008 Nov; 109(5):872-8. PMID: 18946300.
    Citations: 15     Fields:    Translation:Animals
  45. Khaliq ZM, Bean BP. Dynamic, nonlinear feedback regulation of slow pacemaking by A-type potassium current in ventral tegmental area neurons. J Neurosci. 2008 Oct 22; 28(43):10905-17. PMID: 18945898.
    Citations: 26     Fields:    Translation:AnimalsCells
  46. Binshtok AM, Bean BP, Woolf CJ. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature. 2007 Oct 04; 449(7162):607-10. PMID: 17914397.
    Citations: 135     Fields:    Translation:AnimalsCells
  47. Jackson AC, Bean BP. State-dependent enhancement of subthreshold A-type potassium current by 4-aminopyridine in tuberomammillary nucleus neurons. J Neurosci. 2007 Oct 03; 27(40):10785-96. PMID: 17913912.
    Citations: 16     Fields:    Translation:AnimalsCells
  48. Bean BP. Neurophysiology: stressful pacemaking. Nature. 2007 Jun 28; 447(7148):1059-60. PMID: 17597746.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  49. Bean BP. The action potential in mammalian central neurons. Nat Rev Neurosci. 2007 Jun; 8(6):451-65. PMID: 17514198.
    Citations: 524     Fields:    Translation:HumansAnimalsCells
  50. Puopolo M, Raviola E, Bean BP. Roles of subthreshold calcium current and sodium current in spontaneous firing of mouse midbrain dopamine neurons. J Neurosci. 2007 Jan 17; 27(3):645-56. PMID: 17234596.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  51. Martina M, Metz AE, Bean BP. Voltage-dependent potassium currents during fast spikes of rat cerebellar Purkinje neurons: inhibition by BDS-I toxin. J Neurophysiol. 2007 Jan; 97(1):563-71. PMID: 17065256.
    Citations: 24     Fields:    Translation:AnimalsCells
  52. Puopolo M, Bean BP, Raviola E. Spontaneous activity of isolated dopaminergic periglomerular cells of the main olfactory bulb. J Neurophysiol. 2005 Nov; 94(5):3618-27. PMID: 16033943.
    Citations: 26     Fields:    Translation:AnimalsCells
  53. Swensen AM, Bean BP. Robustness of burst firing in dissociated purkinje neurons with acute or long-term reductions in sodium conductance. J Neurosci. 2005 Apr 06; 25(14):3509-20. PMID: 15814781.
    Citations: 87     Fields:    Translation:AnimalsCells
  54. Bean BP. The molecular machinery of resurgent sodium current revealed. Neuron. 2005 Jan 20; 45(2):185-7. PMID: 15664169.
    Citations: 8     Fields:    Translation:Cells
  55. McDonough SI, Mori Y, Bean BP. FPL 64176 modification of Ca(V)1.2 L-type calcium channels: dissociation of effects on ionic current and gating current. Biophys J. 2005 Jan; 88(1):211-23. PMID: 15501945.
    Citations: 22     Fields:    Translation:AnimalsCells
  56. Jackson AC, Yao GL, Bean BP. Mechanism of spontaneous firing in dorsomedial suprachiasmatic nucleus neurons. J Neurosci. 2004 Sep 15; 24(37):7985-98. PMID: 15371499.
    Citations: 67     Fields:    Translation:AnimalsCells
  57. Do MT, Bean BP. Sodium currents in subthalamic nucleus neurons from Nav1.6-null mice. J Neurophysiol. 2004 Aug; 92(2):726-33. PMID: 15056687.
    Citations: 39     Fields:    Translation:AnimalsCells
  58. Blair NT, Bean BP. Role of tetrodotoxin-resistant Na+ current slow inactivation in adaptation of action potential firing in small-diameter dorsal root ganglion neurons. J Neurosci. 2003 Nov 12; 23(32):10338-50. PMID: 14614093.
    Citations: 54     Fields:    Translation:AnimalsCells
  59. Swensen AM, Bean BP. Ionic mechanisms of burst firing in dissociated Purkinje neurons. J Neurosci. 2003 Oct 22; 23(29):9650-63. PMID: 14573545.
    Citations: 98     Fields:    Translation:AnimalsCells
  60. Do MT, Bean BP. Subthreshold sodium currents and pacemaking of subthalamic neurons: modulation by slow inactivation. Neuron. 2003 Jul 03; 39(1):109-20. PMID: 12848936.
    Citations: 102     Fields:    Translation:AnimalsCells
  61. Martina M, Yao GL, Bean BP. Properties and functional role of voltage-dependent potassium channels in dendrites of rat cerebellar Purkinje neurons. J Neurosci. 2003 Jul 02; 23(13):5698-707. PMID: 12843273.
    Citations: 49     Fields:    Translation:AnimalsCells
  62. Mitterdorfer J, Bean BP. Potassium currents during the action potential of hippocampal CA3 neurons. J Neurosci. 2002 Dec 01; 22(23):10106-15. PMID: 12451111.
    Citations: 48     Fields:    Translation:AnimalsCells
  63. Blair NT, Bean BP. Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons. J Neurosci. 2002 Dec 01; 22(23):10277-90. PMID: 12451128.
    Citations: 142     Fields:    Translation:AnimalsCells
  64. McDonough SI, Boland LM, Mintz IM, Bean BP. Interactions among toxins that inhibit N-type and P-type calcium channels. J Gen Physiol. 2002 Apr; 119(4):313-28. PMID: 11929883.
    Citations: 23     Fields:    Translation:AnimalsCells
  65. Taddese A, Bean BP. Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron. 2002 Feb 14; 33(4):587-600. PMID: 11856532.
    Citations: 100     Fields:    Translation:AnimalsCells
  66. Raman IM, Bean BP. Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms. Biophys J. 2001 Feb; 80(2):729-37. PMID: 11159440.
    Citations: 91     Fields:    Translation:AnimalsCells
  67. Bean BP. Modulating modulation. J Gen Physiol. 2000 Mar; 115(3):273-5. PMID: 10694256.
    Citations: 2     Fields:    Translation:Cells
  68. Greif GJ, Sodickson DL, Bean BP, Neer EJ, Mende U. Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking Galpha(o). J Neurophysiol. 2000 Feb; 83(2):1010-8. PMID: 10669512.
    Citations: 10     Fields:    Translation:AnimalsCells
  69. Raman IM, Bean BP. Properties of sodium currents and action potential firing in isolated cerebellar Purkinje neurons. Ann N Y Acad Sci. 1999 Apr 30; 868:93-6. PMID: 10414287.
    Citations: 14     Fields:    Translation:AnimalsCells
  70. Burgess DL, Biddlecome GH, McDonough SI, Diaz ME, Zilinski CA, Bean BP, Campbell KP, Noebels JL. beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain. Mol Cell Neurosci. 1999 Apr; 13(4):293-311. PMID: 10328888.
    Citations: 25     Fields:    Translation:AnimalsCells
  71. Raman IM, Bean BP. Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons. J Neurosci. 1999 Mar 01; 19(5):1663-74. PMID: 10024353.
    Citations: 159     Fields:    Translation:AnimalsCells
  72. McDonough SI, Bean BP. Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons. Mol Pharmacol. 1998 Dec; 54(6):1080-7. PMID: 9855637.
    Citations: 46     Fields:    Translation:AnimalsCells
  73. Sodickson DL, Bean BP. Neurotransmitter activation of inwardly rectifying potassium current in dissociated hippocampal CA3 neurons: interactions among multiple receptors. J Neurosci. 1998 Oct 15; 18(20):8153-62. PMID: 9763462.
    Citations: 29     Fields:    Translation:AnimalsCells
  74. Feigenspan A, Gustincich S, Bean BP, Raviola E. Spontaneous activity of solitary dopaminergic cells of the retina. J Neurosci. 1998 Sep 01; 18(17):6776-89. PMID: 9712649.
    Citations: 41     Fields:    Translation:Animals
  75. Bean BP, McDonough SI. Two for T. Neuron. 1998 May; 20(5):825-8. PMID: 9620687.
    Citations: 8     Fields:    Translation:AnimalsCells
  76. McDonough SI, Lampe RA, Keith RA, Bean BP. Voltage-dependent inhibition of N- and P-type calcium channels by the peptide toxin omega-grammotoxin-SIA. Mol Pharmacol. 1997 Dec; 52(6):1095-104. PMID: 9415720.
    Citations: 30     Fields:    Translation:AnimalsCells
  77. Raman IM, Sprunger LK, Meisler MH, Bean BP. Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron. 1997 Oct; 19(4):881-91. PMID: 9354334.
    Citations: 147     Fields:    Translation:AnimalsCells
  78. Raman IM, Bean BP. Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons. J Neurosci. 1997 Jun 15; 17(12):4517-26. PMID: 9169512.
    Citations: 235     Fields:    Translation:AnimalsCells
  79. McDonough SI, Mintz IM, Bean BP. Alteration of P-type calcium channel gating by the spider toxin omega-Aga-IVA. Biophys J. 1997 May; 72(5):2117-28. PMID: 9129813.
    Citations: 21     Fields:    Translation:AnimalsCells
  80. Sodickson DL, Bean BP. GABAB receptor-activated inwardly rectifying potassium current in dissociated hippocampal CA3 neurons. J Neurosci. 1996 Oct 15; 16(20):6374-85. PMID: 8815916.
    Citations: 85     Fields:    Translation:Animals
  81. McDonough SI, Swartz KJ, Mintz IM, Boland LM, Bean BP. Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIIC. J Neurosci. 1996 Apr 15; 16(8):2612-23. PMID: 8786437.
    Citations: 48     Fields:    Translation:AnimalsCells
  82. Cardozo DL, Bean BP. Voltage-dependent calcium channels in rat midbrain dopamine neurons: modulation by dopamine and GABAB receptors. J Neurophysiol. 1995 Sep; 74(3):1137-48. PMID: 7500139.
    Citations: 36     Fields:    Translation:Animals
  83. Kuo CC, Bean BP. Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons. Mol Pharmacol. 1994 Oct; 46(4):716-25. PMID: 7969051.
    Citations: 50     Fields:    Translation:AnimalsCells
  84. Boland LM, Morrill JA, Bean BP. omega-Conotoxin block of N-type calcium channels in frog and rat sympathetic neurons. J Neurosci. 1994 Aug; 14(8):5011-27. PMID: 8046465.
    Citations: 58     Fields:    Translation:AnimalsCells
  85. Kuo CC, Bean BP. Na+ channels must deactivate to recover from inactivation. Neuron. 1994 Apr; 12(4):819-29. PMID: 8161454.
    Citations: 136     Fields:    Translation:AnimalsCells
  86. Bean B. Taking the beta test. Nature. 1994 Mar 03; 368(6466):15-6. PMID: 8107877.
    Citations: 1     Fields:    Translation:AnimalsCells
  87. Sah DW, Bean BP. Inhibition of P-type and N-type calcium channels by dopamine receptor antagonists. Mol Pharmacol. 1994 Jan; 45(1):84-92. PMID: 8302284.
    Citations: 12     Fields:    Translation:AnimalsCells
  88. Mintz IM, Bean BP. Block of calcium channels in rat neurons by synthetic omega-Aga-IVA. Neuropharmacology. 1993 Nov; 32(11):1161-9. PMID: 8107970.
    Citations: 21     Fields:    Translation:AnimalsCells
  89. Adams ME, Mintz IM, Reily MD, Thanabal V, Bean BP. Structure and properties of omega-agatoxin IVB, a new antagonist of P-type calcium channels. Mol Pharmacol. 1993 Oct; 44(4):681-8. PMID: 8232218.
    Citations: 17     Fields:    Translation:AnimalsCells
  90. Kuo CC, Bean BP. G-protein modulation of ion permeation through N-type calcium channels. Nature. 1993 Sep 16; 365(6443):258-62. PMID: 8396731.
    Citations: 19     Fields:    Translation:AnimalsCells
  91. Mintz IM, Bean BP. GABAB receptor inhibition of P-type Ca2+ channels in central neurons. Neuron. 1993 May; 10(5):889-98. PMID: 8388225.
    Citations: 62     Fields:    Translation:AnimalsCells
  92. Boland LM, Bean BP. Modulation of N-type calcium channels in bullfrog sympathetic neurons by luteinizing hormone-releasing hormone: kinetics and voltage dependence. J Neurosci. 1993 Feb; 13(2):516-33. PMID: 7678856.
    Citations: 63     Fields:    Translation:AnimalsCells
  93. Swartz KJ, Merritt A, Bean BP, Lovinger DM. Protein kinase C modulates glutamate receptor inhibition of Ca2+ channels and synaptic transmission. Nature. 1993 Jan 14; 361(6408):165-8. PMID: 8380626.
    Citations: 33     Fields:    Translation:AnimalsCells
  94. Swartz KJ, Bean BP. Inhibition of calcium channels in rat CA3 pyramidal neurons by a metabotropic glutamate receptor. J Neurosci. 1992 Nov; 12(11):4358-71. PMID: 1359036.
    Citations: 18     Fields:    Translation:AnimalsCells
  95. Hillyard DR, Monje VD, Mintz IM, Bean BP, Nadasdi L, Ramachandran J, Miljanich G, Azimi-Zoonooz A, McIntosh JM, Cruz LJ, et al. A new Conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron. 1992 Jul; 9(1):69-77. PMID: 1352986.
    Citations: 94     Fields:    Translation:AnimalsCells
  96. Mintz IM, Adams ME, Bean BP. P-type calcium channels in rat central and peripheral neurons. Neuron. 1992 Jul; 9(1):85-95. PMID: 1321648.
    Citations: 166     Fields:    Translation:AnimalsCells
  97. Bean BP. Pharmacology and electrophysiology of ATP-activated ion channels. Trends Pharmacol Sci. 1992 Mar; 13(3):87-90. PMID: 1374198.
    Citations: 83     Fields:    Translation:AnimalsCells
  98. Mintz IM, Venema VJ, Swiderek KM, Lee TD, Bean BP, Adams ME. P-type calcium channels blocked by the spider toxin omega-Aga-IVA. Nature. 1992 Feb 27; 355(6363):827-9. PMID: 1311418.
    Citations: 176     Fields:    Translation:AnimalsCells
  99. Bean BP. Whole-cell recording of calcium channel currents. Methods Enzymol. 1992; 207:181-93. PMID: 1326702.
    Citations: 10     Fields:    Translation:Cells
  100. Mintz IM, Venema VJ, Adams ME, Bean BP. Inhibition of N- and L-type Ca2+ channels by the spider venom toxin omega-Aga-IIIA. Proc Natl Acad Sci U S A. 1991 Aug 01; 88(15):6628-31. PMID: 1713686.
    Citations: 21     Fields:    Translation:AnimalsCells
  101. Bean BP. Pharmacology of calcium channels in cardiac muscle, vascular muscle, and neurons. Am J Hypertens. 1991 Jul; 4(7 Pt 2):406S-411S. PMID: 1654934.
    Citations: 2     Fields:    Translation:AnimalsCells
  102. Regan LJ, Sah DW, Bean BP. Ca2+ channels in rat central and peripheral neurons: high-threshold current resistant to dihydropyridine blockers and omega-conotoxin. Neuron. 1991 Feb; 6(2):269-80. PMID: 1847065.
    Citations: 83     Fields:    Translation:AnimalsCells
  103. Bean B. Calcium channels. Gating for the physiologist. Nature. 1990 Nov 15; 348(6298):192-3. PMID: 1978254.
    Citations: 5     Fields:    Translation:Cells
  104. Friel DD, Bean BP. Dual control by ATP and acetylcholine of inwardly rectifying K+ channels in bovine atrial cells. Pflugers Arch. 1990 Mar; 415(6):651-7. PMID: 2336344.
    Citations: 13     Fields:    Translation:Animals
  105. Bean BP, Friel DD. ATP-activated channels in excitable cells. Ion Channels. 1990; 2:169-203. PMID: 1715204.
    Citations: 30     Fields:    Translation:HumansAnimals
  106. Bean BP. ATP-activated channels in rat and bullfrog sensory neurons: concentration dependence and kinetics. J Neurosci. 1990 Jan; 10(1):1-10. PMID: 1688928.
    Citations: 70     Fields:    Translation:AnimalsCells
  107. Bean BP, Williams CA, Ceelen PW. ATP-activated channels in rat and bullfrog sensory neurons: current-voltage relation and single-channel behavior. J Neurosci. 1990 Jan; 10(1):11-9. PMID: 1688930.
    Citations: 37     Fields:    Translation:AnimalsCells
  108. Bean BP. Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature. 1989 Jul 13; 340(6229):153-6. PMID: 2567963.
    Citations: 231     Fields:    Translation:AnimalsCells
  109. Bean BP, Rios E. Nonlinear charge movement in mammalian cardiac ventricular cells. Components from Na and Ca channel gating. J Gen Physiol. 1989 Jul; 94(1):65-93. PMID: 2553859.
    Citations: 54     Fields:    Translation:AnimalsCells
  110. Bean B. More than a Ca2+ channel? Trends Neurosci. 1989 Apr; 12(4):128-30. PMID: 2470169.
    Citations: 4     Fields:    Translation:Animals
  111. Bean BP. Classes of calcium channels in vertebrate cells. Annu Rev Physiol. 1989; 51:367-84. PMID: 2540697.
    Citations: 203     Fields:    Translation:AnimalsCells
  112. Bean BP. Multiple types of calcium channels in heart muscle and neurons. Modulation by drugs and neurotransmitters. Ann N Y Acad Sci. 1989; 560:334-45. PMID: 2568109.
    Citations: 15     Fields:    Translation:AnimalsCells
  113. Huettner JE, Bean BP. Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc Natl Acad Sci U S A. 1988 Feb; 85(4):1307-11. PMID: 2448800.
    Citations: 187     Fields:    Translation:AnimalsCells
  114. Friel DD, Bean BP. Two ATP-activated conductances in bullfrog atrial cells. J Gen Physiol. 1988 Jan; 91(1):1-27. PMID: 3257791.
    Citations: 44     Fields:    Translation:Animals
  115. Triggle DJ, Lazdunski M, Bean BP. [Calcium channels and calcium antagonists]. Med Monatsschr Pharm. 1986 Dec; 9(12):363-4. PMID: 2433568.
    Citations:    Fields:    Translation:Humans
  116. Bean BP, Sturek M, Puga A, Hermsmeyer K. Calcium channels in muscle cells isolated from rat mesenteric arteries: modulation by dihydropyridine drugs. Circ Res. 1986 Aug; 59(2):229-35. PMID: 2427250.
    Citations: 103     Fields:    Translation:Animals
  117. Tsien RW, Bean BP, Hess P, Lansman JB, Nilius B, Nowycky MC. Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists. J Mol Cell Cardiol. 1986 Jul; 18(7):691-710. PMID: 2427730.
    Citations: 142     Fields:    Translation:AnimalsCells
  118. Bean BP. Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology. J Gen Physiol. 1985 Jul; 86(1):1-30. PMID: 2411846.
    Citations: 230     Fields:    Translation:Animals
  119. Bean BP. Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc Natl Acad Sci U S A. 1984 Oct; 81(20):6388-92. PMID: 6093100.
    Citations: 217     Fields:    Translation:Animals
  120. Cohen CJ, Bean BP, Tsien RW. Maximal upstroke velocity as an index of available sodium conductance. Comparison of maximal upstroke velocity and voltage clamp measurements of sodium current in rabbit Purkinje fibers. Circ Res. 1984 Jun; 54(6):636-51. PMID: 6329543.
    Citations: 43     Fields:    Translation:Animals
  121. Bean BP, Nowycky MC, Tsien RW. Beta-adrenergic modulation of calcium channels in frog ventricular heart cells. Nature. 1984 Jan 26-Feb 1; 307(5949):371-5. PMID: 6320002.
    Citations: 122     Fields:    Translation:Animals
  122. Bean BP, Cohen CJ, Tsien RW. Lidocaine block of cardiac sodium channels. J Gen Physiol. 1983 May; 81(5):613-42. PMID: 6306139.
    Citations: 193     Fields:    Translation:Animals
  123. Tsien RW, Bean BP, Hess P, Nowycky M. Calcium channels: mechanisms of beta-adrenergic modulation and ion permeation. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:201-12. PMID: 6327154.
    Citations: 16     Fields:    Translation:AnimalsCells
  124. Cohen CJ, Bean BP, Colatsky TJ, Tsien RW. Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating. J Gen Physiol. 1981 Oct; 78(4):383-411. PMID: 6270235.
    Citations: 62     Fields:    Translation:Animals
  125. Bean BP. Sodium channel inactivation in the crayfish giant axon. Must channels open before inactivating? Biophys J. 1981 Sep; 35(3):595-614. PMID: 6268217.
    Citations: 55     Fields:    Translation:AnimalsCells
  126. Bean BP, Shrager P, Goldstein DA. Modification of sodium and potassium channel gating kinetics by ether and halothane. J Gen Physiol. 1981 Mar; 77(3):233-53. PMID: 6265590.
    Citations: 22     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.