Harvard Catalyst Profiles

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Alex John Kreutzberger, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kreutzberger AJB, Sanyal A, Saminathan A, Bloyet LM, Stumpf S, Liu Z, Ojha R, Patjas MT, Geneid A, Scanavachi G, Doyle CA, Somerville E, Correia RBDC, Di Caprio G, Toppila-Salmi S, Mäkitie A, Kiessling V, Vapalahti O, Whelan SPJ, Balistreri G, Kirchhausen T. SARS-CoV-2 requires acidic pH to infect cells. Proc Natl Acad Sci U S A. 2022 09 20; 119(38):e2209514119. PMID: 36048924; PMCID: PMC9499588.
    Citations: 1     Fields:    Translation:HumansCells
  2. Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW. An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion. Sci Immunol. 2022 10 28; 7(76):eadd5446. PMID: 35951767; PMCID: PMC9407951.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  3. Kreutzberger AJB, Sanyal A, Ojha R, Pyle JD, Vapalahti O, Balistreri G, Kirchhausen T. Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease. J Virol. 2021 10 13; 95(21):e0097521. PMID: 34406858; PMCID: PMC8513479.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  4. Kreutzberger AJB, Sanyal A, Ojha R, Pyle JD, Vapalahti O, Balistreri G, Kirchhausen T. Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease. bioRxiv. 2021 Aug 12. PMID: 34100014; PMCID: PMC8183009.
  5. Chou YY, Upadhyayula S, Houser J, He K, Skillern W, Scanavachi G, Dang S, Sanyal A, Ohashi KG, Di Caprio G, Kreutzberger AJB, Vadakkan TJ, Kirchhausen T. Inherited nuclear pore substructures template post-mitotic pore assembly. Dev Cell. 2021 06 21; 56(12):1786-1803.e9. PMID: 34129835; PMCID: PMC8261643.
    Citations: 3     Fields:    Translation:HumansCells
  6. Narahari AK, Kreutzberger AJ, Gaete PS, Chiu YH, Leonhardt SA, Medina CB, Jin X, Oleniacz PW, Kiessling V, Barrett PQ, Ravichandran KS, Yeager M, Contreras JE, Tamm LK, Bayliss DA. ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels. Elife. 2021 01 07; 10. PMID: 33410749; PMCID: PMC7806264.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  7. Zang R, Case JB, Yutuc E, Ma X, Shen S, Gomez Castro MF, Liu Z, Zeng Q, Zhao H, Son J, Rothlauf PW, Kreutzberger AJB, Hou G, Zhang H, Bose S, Wang X, Vahey MD, Mani K, Griffiths WJ, Kirchhausen T, Fremont DH, Guo H, Diwan A, Wang Y, Diamond MS, Whelan SPJ, Ding S. Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Proc Natl Acad Sci U S A. 2020 12 15; 117(50):32105-32113. PMID: 33239446; PMCID: PMC7749331.
    Citations: 63     Fields:    Translation:HumansCells
  8. Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, Kattan I, Harris M, Liang B, Kenworthy AK, Desai BN, Leitinger N, Anantharam A, Castle JD, Tamm LK. Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2. Elife. 2020 11 09; 9. PMID: 33164744.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  9. Bendahmane M, Morales A, Kreutzberger AJB, Schenk NA, Mohan R, Bakshi S, Philippe JM, Zhang S, Kiessling V, Tamm LK, Giovannucci DR, Jenkins PM, Anantharam A. Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos. J Neurochem. 2020 09; 154(6):598-617. PMID: 32058590.
    Citations: 5     Fields:    Translation:AnimalsCells
  10. Kreutzberger AJB, Kiessling V, Stroupe C, Liang B, Preobraschenski J, Ganzella M, Kreutzberger MAB, Nakamoto R, Jahn R, Castle JD, Tamm LK. In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties. Nat Commun. 2019 08 29; 10(1):3904. PMID: 31467284.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  11. Anantharam A, Kreutzberger AJB. Unraveling the mechanisms of calcium-dependent secretion. J Gen Physiol. 2019 04 01; 151(4):417-434. PMID: 30782604; PMCID: PMC6445591.
    Citations: 6     Fields:    Translation:AnimalsCells
  12. Kreutzberger AJB, Ji M, Aaron J, Mihaljevic L, Urban S. Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion. Science. 2019 02 01; 363(6426). PMID: 30705155; PMCID: PMC6368390.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  13. Kiessling V, Kreutzberger AJB, Liang B, Nyenhuis SB, Seelheim P, Castle JD, Cafiso DS, Tamm LK. A molecular mechanism for calcium-mediated synaptotagmin-triggered exocytosis. Nat Struct Mol Biol. 2018 10; 25(10):911-917. PMID: 30291360; PMCID: PMC6176490.
    Citations: 13     Fields:    Translation:AnimalsCells
  14. Kreutzberger AJB, Urban S. Single-Molecule Analyses Reveal Rhomboid Proteins Are Strict and Functional Monomers in the Membrane. Biophys J. 2018 11 06; 115(9):1755-1761. PMID: 30342748; PMCID: PMC6224778.
    Citations: 5     Fields:    Translation:Cells
  15. Hussain SS, Harris MT, Kreutzberger AJB, Inouye CM, Doyle CA, Castle AM, Arvan P, Castle JD. Control of insulin granule formation and function by the ABC transporters ABCG1 and ABCA1 and by oxysterol binding protein OSBP. Mol Biol Cell. 2018 05 15; 29(10):1238-1257. PMID: 29540530; PMCID: PMC5935073.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  16. Kreutzberger AJB, Kiessling V, Liang B, Yang ST, Castle JD, Tamm LK. Asymmetric Phosphatidylethanolamine Distribution Controls Fusion Pore Lifetime and Probability. Biophys J. 2017 Nov 07; 113(9):1912-1915. PMID: 29037600; PMCID: PMC5685784.
    Citations: 15     Fields:    Translation:Cells
  17. Kreutzberger AJB, Kiessling V, Liang B, Seelheim P, Jakhanwal S, Jahn R, Castle JD, Tamm LK. Reconstitution of calcium-mediated exocytosis of dense-core vesicles. Sci Adv. 2017 07; 3(7):e1603208. PMID: 28776026.
    Citations: 25     Fields:    Translation:HumansCells
  18. Yang ST, Kreutzberger AJB, Kiessling V, Ganser-Pornillos BK, White JM, Tamm LK. HIV virions sense plasma membrane heterogeneity for cell entry. Sci Adv. 2017 06; 3(6):e1700338. PMID: 28782011.
    Citations: 31     Fields:    Translation:HumansCells
  19. Zdanowicz R, Kreutzberger A, Liang B, Kiessling V, Tamm LK, Cafiso DS. Complexin Binding to Membranes and Acceptor t-SNAREs Explains Its Clamping Effect on Fusion. Biophys J. 2017 Sep 19; 113(6):1235-1250. PMID: 28456331; PMCID: PMC5607037.
    Citations: 13     Fields:    Translation:AnimalsCells
  20. Kiessling V, Liang B, Kreutzberger AJ, Tamm LK. Planar Supported Membranes with Mobile SNARE Proteins and Quantitative Fluorescence Microscopy Assays to Study Synaptic Vesicle Fusion. Front Mol Neurosci. 2017; 10:72. PMID: 28360838; PMCID: PMC5352703.
    Citations: 10     
  21. Yang ST, Kreutzberger AJB, Lee J, Kiessling V, Tamm LK. The role of cholesterol in membrane fusion. Chem Phys Lipids. 2016 09; 199:136-143. PMID: 27179407; PMCID: PMC4972649.
    Citations: 82     Fields:    Translation:HumansAnimals
  22. Kreutzberger AJ, Liang B, Kiessling V, Tamm LK. Assembly and Comparison of Plasma Membrane SNARE Acceptor Complexes. Biophys J. 2016 May 24; 110(10):2147-50. PMID: 27178662; PMCID: PMC4881159.
    Citations: 13     Fields:    Translation:AnimalsCells
  23. Kreutzberger AJ, Kiessling V, Tamm LK. High cholesterol obviates a prolonged hemifusion intermediate in fast SNARE-mediated membrane fusion. Biophys J. 2015 Jul 21; 109(2):319-29. PMID: 26200867; PMCID: PMC4621810.
    Citations: 25     Fields:    Translation:AnimalsCells
  24. Hernandez JM, Kreutzberger AJ, Kiessling V, Tamm LK, Jahn R. Variable cooperativity in SNARE-mediated membrane fusion. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):12037-42. PMID: 25092301.
    Citations: 48     Fields:    
  25. Kreutzberger AJ, Pokorny A. On the origin of multiphasic kinetics in peptide binding to phospholipid vesicles. J Phys Chem B. 2012 Jan 26; 116(3):951-7. PMID: 22242648.
    Citations: 4     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.