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profileCharles R. Vanderburg, Ph.D.

TitleInstructor in Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Department of Neurology, 2725D
114 16th Street
Charlestown MA 02129
Phone617/726-6389
Fax617/724-2659
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Following fellowships at Harvard Medical School and Massachusetts General Hospital, Dr. Vanderburg joined the Harvard NeuroDiscovery Center as the director of the Advanced Tissue Resource Center at the MassGeneral Institute for Neurodegenerative Disease. Dr. Vanderburg has published on a wide range of neurological disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, autism, and bipolar disorder. His current research focus is on the microgenomic and microproteomic profiling of human neuropathological tissue specimens and their derivatives, including miRNAs and exosomes. With a focus on developing artifact-control methodologies for such specimens, the lab is actively investigating novel bioinformatic strategies and technologies.


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R21MH086079     (DELALLE, IVANA)Jul 15, 2010 - Aug 31, 2013
NIH/NIMH
Exosomal and cell-class specific miRNA profiles in bipolar disorder and schizophr
Role: Co-Principal Investigator
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in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Harvard NeuroDiscovery Center - Advanced Tissue Resource Center (HMS) - Core services (5), Instruments (11), Primers (45) and Protocols (9)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Marquié M, Verwer EE, Meltzer AC, Kim SJW, Agüero C, Gonzalez J, Makaretz SJ, Siao Tick Chong M, Ramanan P, Amaral AC, Normandin MD, Vanderburg CR, Gomperts SN, Johnson KA, Frosch MP, Gómez-Isla T. Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case. Acta Neuropathol Commun. 2017 Oct 19; 5(1):75. PMID: 29047416.
    View in: PubMed
  2. DiVincenzo MJ, Frydman GH, Kowaleski MP, Vanderburg CR, Lai B, Oura TJ, Jennings SH. Metallosis in a Dog as a Long-Term Complication Following Total Hip Arthroplasty. Vet Pathol. 2017 Sep; 54(5):828-831. PMID: 28651457.
    View in: PubMed
  3. Frydman GH, Marini RP, Bakthavatchalu V, Biddle KE, Muthupalani S, Vanderburg CR, Lai B, Bendapudi PK, Tompkins RG, Fox JG. Local and Systemic Changes Associated with Long-term, Percutaneous, Static Implantation of Titanium Alloys in Rhesus Macaques (Macaca mulatta). Comp Med. 2017 Mar 01; 67(2):165-175. PMID: 28381317.
    View in: PubMed
  4. Choi JL, Kao PF, Itriago E, Zhan Y, Kozubek JA, Hoss AG, Banigan MG, Vanderburg CR, Rezvani AH, Latourelle JC, Cabral H, Delalle I. miR-149 and miR-29c as candidates for bipolar disorder biomarkers. Am J Med Genet B Neuropsychiatr Genet. 2017 Apr; 174(3):315-323. PMID: 28190298.
    View in: PubMed
  5. Chen X, Chen H, Cai W, Maguire M, Ya B, Zuo F, Logan R, Li H, Robinson K, Vanderburg CR, Yu Y, Wang Y, Fisher DE, Schwarzschild MA. The melanoma-linked "redhead" MC1R influences dopaminergic neuron survival. Ann Neurol. 2017 Mar; 81(3):395-406. PMID: 28019657.
    View in: PubMed
  6. Beheshti A, Vanderburg C, McDonald JT, Ramkumar C, Kadungure T, Zhang H, Gartenhaus RB, Evens AM. A Circulating microRNA Signature Predicts Age-Based Development of Lymphoma. PLoS One. 2017; 12(1):e0170521. PMID: 28107482.
    View in: PubMed
  7. Marquié M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Antón-Fernández A, Klunk WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S, DeVos SL, Oakley DH, Gomperts SN, Growdon JH, Domoto-Reilly K, Lucente D, Dickerson BC, Frosch MP, Hyman BT, Johnson KA, Gómez-Isla T. Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies. Ann Neurol. 2017 Jan; 81(1):117-128. PMID: 27997036.
    View in: PubMed
  8. Frydman GH, Bendapudi PK, Marini RP, Vanderburg CR, Tompkins RG, Fox JG. Coagulation Biomarkers in Healthy Chinese-Origin Rhesus Macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2016; 55(3):252-9. PMID: 27177557; PMCID: PMC4865685 [Available on 11/01/16].
  9. Beheshti A, Neuberg D, McDonald JT, Vanderburg CR, Evens AM. The Impact of Age and Sex in DLBCL: Systems Biology Analyses Identify Distinct Molecular Changes and Signaling Networks. Cancer Inform. 2015; 14:141-8. PMID: 26691437; PMCID: PMC4676434.
  10. Marquié M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, Frosch MP, Hyman BT, Gómez-Isla T. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol. 2015 Nov; 78(5):787-800. PMID: 26344059; PMCID: PMC4900162 [Available on 11/01/16].
  11. Clarke MS, Sundaresan A, Vanderburg CR, Banigan MG, Pellis NR. A three-dimensional tissue culture model of bone formation utilizing rotational co-culture of human adult osteoblasts and osteoclasts. Acta Biomater. 2013 Aug; 9(8):7908-16. PMID: 23664885.
    View in: PubMed
  12. Wong HK, Veremeyko T, Patel N, Lemere CA, Walsh DM, Esau C, Vanderburg C, Krichevsky AM. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Hum Mol Genet. 2013 Aug 01; 22(15):3077-92. PMID: 23585551.
    View in: PubMed
  13. Banigan MG, Kao PF, Kozubek JA, Winslow AR, Medina J, Costa J, Schmitt A, Schneider A, Cabral H, Cagsal-Getkin O, Vanderburg CR, Delalle I. Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients. PLoS One. 2013; 8(1):e48814. PMID: 23382797; PMCID: PMC3559697.
  14. Hu B, Jiang G, Pang C, Wang S, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Deng Y, Huang X. Assessment of gene order computing methods for Alzheimer's disease. BMC Med Genomics. 2013; 6 Suppl 1:S8. PMID: 23369541; PMCID: PMC3552676.
  15. Vanderburg CR, Clarke MS. Laser capture microdissection of metachromatically stained skeletal muscle allows quantification of fiber type specific gene expression. Mol Cell Biochem. 2013 Mar; 375(1-2):159-70. PMID: 23196635.
    View in: PubMed
  16. Danzer KM, Kranich LR, Ruf WP, Cagsal-Getkin O, Winslow AR, Zhu L, Vanderburg CR, McLean PJ. Exosomal cell-to-cell transmission of alpha synuclein oligomers. Mol Neurodegener. 2012 Aug 24; 7:42. PMID: 22920859; PMCID: PMC3483256.
  17. Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I. Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology. J Neuropathol Exp Neurol. 2012 Jul; 71(7):654-64. PMID: 22710966; PMCID: PMC3398703.
  18. Arboleda-Velasquez JF, Manent J, Lee JH, Tikka S, Ospina C, Vanderburg CR, Frosch MP, Rodríguez-Falcón M, Villen J, Gygi S, Lopera F, Kalimo H, Moskowitz MA, Ayata C, Louvi A, Artavanis-Tsakonas S. Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):E128-35. PMID: 21555590; PMCID: PMC3102344.
  19. Unni VK, Ebrahimi-Fakhari D, Vanderburg CR, McLean PJ, Hyman BT. Studying protein degradation pathways in vivo using a cranial window-based approach. Methods. 2011 Mar; 53(3):194-200. PMID: 21187150; PMCID: PMC3057351.
  20. Kao PF, Davis DA, Banigan MG, Vanderburg CR, Seshadri S, Delalle I. Modulators of cytoskeletal reorganization in CA1 hippocampal neurons show increased expression in patients at mid-stage Alzheimer's disease. PLoS One. 2010 Oct 13; 5(10):e13337. PMID: 20967212; PMCID: PMC2954170.
  21. Cho HH, Cahill CM, Vanderburg CR, Scherzer CR, Wang B, Huang X, Rogers JT. Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1. J Biol Chem. 2010 Oct 08; 285(41):31217-32. PMID: 20558735; PMCID: PMC2951196.
  22. Pang CY, Hu W, Hu BQ, Shi Y, Vanderburg CR, Rogers JT, Huang X. A special local clustering algorithm for identifying the genes associated with Alzheimer's disease. IEEE Trans Nanobioscience. 2010 Mar; 9(1):44-50. PMID: 20089478; PMCID: PMC3008360.
  23. Kwiatkowski TJ, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science. 2009 Feb 27; 323(5918):1205-8. PMID: 19251627.
    View in: PubMed
  24. Kong W, Mou X, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Huang X. Independent component analysis of Alzheimer's DNA microarray gene expression data. Mol Neurodegener. 2009 Jan 28; 4:5. PMID: 19173745.
    View in: PubMed
  25. Ferland RJ, Batiz LF, Neal J, Lian G, Bundock E, Lu J, Hsiao YC, Diamond R, Mei D, Banham AH, Brown PJ, Vanderburg CR, Joseph J, Hecht JL, Folkerth R, Guerrini R, Walsh CA, Rodriguez EM, Sheen VL. Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia. Hum Mol Genet. 2009 Feb 01; 18(3):497-516. PMID: 18996916; PMCID: PMC2722192.
  26. Kong W, Vanderburg CR, Gunshin H, Rogers JT, Huang X. A review of independent component analysis application to microarray gene expression data. Biotechniques. 2008 Nov; 45(5):501-20. PMID: 19007336; PMCID: PMC3005719.
  27. Ingelsson M, Ramasamy K, Cantuti-Castelvetri I, Skoglund L, Matsui T, Orne J, Kowa H, Raju S, Vanderburg CR, Augustinack JC, de Silva R, Lees AJ, Lannfelt L, Growdon JH, Frosch MP, Standaert DG, Irizarry MC, Hyman BT. No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain. Acta Neuropathol. 2006 Oct; 112(4):439-49. PMID: 16802167.
    View in: PubMed
  28. Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, Rogers JT, Huang X. Metal exposure and Alzheimer's pathogenesis. J Struct Biol. 2006 Jul; 155(1):45-51. PMID: 16503166.
    View in: PubMed
  29. Lee J, Fukumoto H, Orne J, Klucken J, Raju S, Vanderburg CR, Irizarry MC, Hyman BT, Ingelsson M. Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Exp Neurol. 2005 Jul; 194(1):91-6. PMID: 15899246.
    View in: PubMed
  30. Carterson AJ, Höner zu Bentrup K, Ott CM, Clarke MS, Pierson DL, Vanderburg CR, Buchanan KL, Nickerson CA, Schurr MJ. A549 lung epithelial cells grown as three-dimensional aggregates: alternative tissue culture model for Pseudomonas aeruginosa pathogenesis. Infect Immun. 2005 Feb; 73(2):1129-40. PMID: 15664956; PMCID: PMC547019.
  31. Clarke MS, Vanderburg CR, Feeback DL. The effect of acute microgravity on mechanically-induced membrane damage and membrane-membrane fusion events. J Gravit Physiol. 2001 Dec; 8(2):37-47. PMID: 12365449.
    View in: PubMed
  32. Nickerson CA, Goodwin TJ, Terlonge J, Ott CM, Buchanan KL, Uicker WC, Emami K, LeBlanc CL, Ramamurthy R, Clarke MS, Vanderburg CR, Hammond T, Pierson DL. Three-dimensional tissue assemblies: novel models for the study of Salmonella enterica serovar Typhimurium pathogenesis. Infect Immun. 2001 Nov; 69(11):7106-20. PMID: 11598087; PMCID: PMC100098.
  33. Clarke MS, Vanderburg CR, Bamman MM, Caldwell RW, Feeback DL. In situ localization of cholesterol in skeletal muscle by use of a monoclonal antibody. J Appl Physiol (1985). 2000 Aug; 89(2):731-41. PMID: 10926660.
    View in: PubMed
  34. Sun D, Vanderburg CR, Odierna GS, Hay ED. TGFbeta3 promotes transformation of chicken palate medial edge epithelium to mesenchyme in vitro. Development. 1998 Jan; 125(1):95-105. PMID: 9389667.
    View in: PubMed
  35. Vanderburg CR, Hay ED. E-cadherin transforms embryonic corneal fibroblasts to stratified epithelium with desmosomes. Acta Anat (Basel). 1996; 157(2):87-104. PMID: 9142332.
    View in: PubMed
  36. Clarke MS, Vanderburg CR, Hay ED, McNeil PL. Cytoplasmic loading of dyes, protein and plasmid DNA using an impact-mediated procedure. Biotechniques. 1994 Dec; 17(6):1118-25. PMID: 7532978.
    View in: PubMed
  37. Vanderburg CR, Nathanson MA. Posttranscriptional control of embryonic rat skeletal muscle protein synthesis. Control at the level of translation by endogenous RNA. J Cell Biol. 1988 Sep; 107(3):1085-98. PMID: 3417774; PMCID: PMC2115291.
  38. Nathanson MA, Bush EW, Vanderburg C. Transcriptional-translational regulation of muscle-specific protein synthesis and its relationship to chondrogenic stimuli. J Biol Chem. 1986 Jan 25; 261(3):1477-86. PMID: 2868001.
    View in: PubMed
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