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Vasileios Kokkinos, Ph.D., Ph.D.

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Overview
Dr. Kokkinos received the diploma of Electrical & Computer Engineering and the MSc in Hardware-Software Integrated Systems from the Engineering School of the University of Patras, Greece, in 1998 and 2001. After working in the microelectronics industry, he shifted his interest towards the brain. In the graduate program of the Medical School of the University of Patras, Vasileios received the MSc in Basic Medical Sciences: Neurosciences in 2003, completing a thesis on the neurophysiology of the rat hippocampus. During the same period, he attended the undergraduate program of the Philosophy Department of the University of Patras, from which he graduated in 2005, with a thesis on neuroscience-derived theories of mind on visual perception. In the neurological sciences graduate program at McGill University, he then completed a thesis on the neurophysiology of human eye-head motor coordination, graduating in 2007.

Under the supervision of George K. Kostopoulos, MD, PhD, Dr. Kokkinos then joined the neurophysiology unit of the Medical School of the University of Patras and completed a PhD thesis on the neurophysiology of normal human sleep in 2010. One year of his PhD training (2008-09) was devoted to intense and highly specialized training in epilepsy at the UCL Institute of Neurology, in London. He completed a training/research fellowship on fMRI and EEG-fMRI for presurgical evaluation of epilepsy, under the supervision of John S. Duncan, MD, PhD, and Louis Lemieux, PhD. During the same time, he was accepted in the graduate course on epileptology at King’s College in London, from which he graduated in 2009 with distinction, completing a thesis on invasive electrical cortical stimulation for patients undergoing epilepsy surgery under the supervision of Gonzalo Alarcon, MD, PhD, and Antonio Valentin, MD, PhD. He also attended the research team of the Department of Clinical Neurophysiology and Epilepsies at St. Thomas’ Hospital in London where he was trained in pediatric and adult epileptic EEG by Chrysostomos P. Panayiotopoulos, MD, PhD, and Michalis Koutroumanidis, MD, PhD.

From 2009 to 2016, Dr. Kokkinos was head of neurophysiology and functional neuroimaging of the epilepsy program at St. Luke’s Hospital in Thessaloniki, Greece. His responsibilities in the pediatric and adult epilepsy program included the performance and supervision of procedures during both the non-invasive (video-EEG, MRI, fMRI, EEG-fMRI, DTI-tractography) and the invasive phases (acute and chronic ECoG, cortical electrical stimulation, neuronavigation) of the pre-surgical evaluation and surgical treatment protocol. From 2010 to 2017, Dr. Kokkinos also held a post-doctoral fellowship at the neurophysiology unit of the University of Patras Medical School under the mentorship of Dr. Kostopoulos, focusing on the neurophysiologic relations of sleep and epilepsy. He completed a second PhD thesis on neurophysiological features of focal and generalized epileptic syndromes of childhood in 2016.

In 2017, he joined the Department of Neurological Surgery of the University of Pittsburgh as Instructor. He supported the Comprehensive Epilepsy Program of University of Pittsburgh in surgical sEEG planning, intra-operative coordination and electrode implantation optimization, 3D reconstruction of sEEG implantation, iEEG interpretation and cortical electrical stimulation. He is board-certified for epilepsy surgery neurophysiology (R EEG/PSG/EP T, CNIM, NA-CLTM). Among other works, he discovered and published the first evidence for electrophysiological biomarkers of clinical response to RNS Therapy. He also established the intracranial EEG correlate of the 14&6/sec positive spikes EEG variant, and named it the hippocampal barque. Dr. Kokkinos is Instructor of Neurosurgery at Massachusetts General Hospital and Harvard Medical School since 2019, focused in clinical epilepsy research and providing extensive clinical services to the Epilepsy Surgery Program and the Clinical MEG Program. In 2022, he completed a third PhD thesis on functional neuroimaging for epilepsy and brain tumor surgery.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nascimento FA, Kokkinos V, Emerton BC, Bolden LB, Malik AN, Moura LM, Richardson RM. Laser ablation for refractory mesial temporal lobe epilepsy. Epileptic Disord. 2022 06 01; 24(3):617-620. PMID: 35770756.
    Citations:    Fields:    Translation:Humans
  2. Jiang H, Kokkinos V, Ye S, Urban A, Bagic A, Richardson M, He B. Interictal SEEG Resting-State Connectivity Localizes the Seizure Onset Zone and Predicts Seizure Outcome. Adv Sci (Weinh). 2022 06; 9(18):e2200887. PMID: 35545899; PMCID: PMC9218648.
    Citations: 1     Fields:    Translation:Humans
  3. Kokkinos V, Koupparis AM, Koutroumanidis M, Kostopoulos GK. Editorial: Brain Mechanisms Linking Sleep and Epilepsy. Front Hum Neurosci. 2022; 16:922372. PMID: 35620153; PMCID: PMC9128402.
    Citations:    
  4. Kerezoudis P, Kokkinos V. Commentary: Interictal High Gamma Oscillation Regularity as a Marker for Presurgical Epileptogenic Zone Localization. Oper Neurosurg (Hagerstown). 2022 08 01; 23(2):e114-e116. PMID: 35838462.
    Citations:    Fields:    Translation:Humans
  5. Fragkou A, Kakarountas A, Kokkinos V. Low Power EEG Data Encoding for Brain Neurostimulation Implants. Information. 2022; 13(4):194. View Publication.
  6. Sisterson ND, Kokkinos V, Urban A, Li N, Richardson RM. Responsive neurostimulation of the thalamus improves seizure control in idiopathic generalised epilepsy: initial case series. J Neurol Neurosurg Psychiatry. 2022 05; 93(5):491-498. PMID: 35217517; PMCID: PMC9016239.
    Citations: 1     Fields:    Translation:Humans
  7. Kokkinos V, Urban A, Frauscher B, Simon M, Hussein H, Bush A, Williams Z, Bagic AI, Mark Richardson R. Barques are generated in posterior hippocampus and phase reverse over lateral posterior hippocampal surface. Clin Neurophysiol. 2022 04; 136:150-157. PMID: 35168029.
    Citations:    Fields:    Translation:Humans
  8. Astner-Rohracher A, Zimmermann G, Avigdor T, Abdallah C, Barot N, Brázdil M, Doležalová I, Gotman J, Hall JA, Ikeda K, Kahane P, Kalss G, Kokkinos V, Leitinger M, Mindruta I, Minotti L, Mizera MM, Oane I, Richardson M, Schuele SU, Trinka E, Urban A, Whatley B, Dubeau F, Frauscher B. Development and Validation of the 5-SENSE Score to Predict Focality of the Seizure-Onset Zone as Assessed by Stereoelectroencephalography. JAMA Neurol. 2022 01 01; 79(1):70-79. PMID: 34870697; PMCID: PMC8649918.
    Citations:    Fields:    Translation:Humans
  9. Sokolov E, Sisterson ND, Hussein H, Plummer C, Corson D, Antony AR, Mettenburg JM, Ghearing GR, Pan JW, Urban A, Bagic A, Richardson RM, Kokkinos V. Intracranial monitoring contributes to seizure freedom for temporal lobectomy patients with nonconcordant preoperative data. Epilepsia Open. 2022 03; 7(1):36-45. PMID: 34786887; PMCID: PMC8886064.
    Citations: 3     Fields:    Translation:Humans
  10. Hussein H, Kokkinos V, Sisterson ND, Modo M, Richardson RM. Extrapial Hippocampal Resection in Anterior Temporal Lobectomy: Technical Description and Clinical Outcomes in a 62-Patient Case Series. Oper Neurosurg (Hagerstown). 2021 10 13; 21(5):312-323. PMID: 34333663.
    Citations:    Fields:    Translation:Humans
  11. Kokkinos V, Hussein H, Frauscher B, Simon M, Urban A, Bush A, Bagic AI, Richardson RM. Hippocampal spindles and barques are normal intracranial electroencephalographic entities. Clin Neurophysiol. 2021 12; 132(12):3002-3009. PMID: 34715425.
    Citations:    Fields:    Translation:Humans
  12. Neumann WJ, Memarian Sorkhabi M, Benjaber M, Feldmann LK, Saryyeva A, Krauss JK, Contarino MF, Sieger T, Jech R, Tinkhauser G, Pollo C, Palmisano C, Isaias IU, Cummins DD, Little SJ, Starr PA, Kokkinos V, Gerd-Helge S, Herrington T, Brown P, Richardson RM, Kühn AA, Denison T. The sensitivity of ECG contamination to surgical implantation site in brain computer interfaces. Brain Stimul. 2021 Sep-Oct; 14(5):1301-1306. PMID: 34428554; PMCID: PMC8460992.
    Citations: 7     Fields:    Translation:Humans
  13. Yang JC, Harid NM, Nascimento FA, Kokkinos V, Shaughnessy A, Lam AD, Westover MB, Leslie-Mazwi TM, Hochberg LR, Rosenthal ES, Cole AJ, Richardson RM, Cash SS. Responsive neurostimulation for focal motor status epilepticus. Ann Clin Transl Neurol. 2021 06; 8(6):1353-1361. PMID: 33955717; PMCID: PMC8164849.
    Citations:    Fields:    Translation:Humans
  14. Constantino AC, Sisterson ND, Zaher N, Urban A, Richardson RM, Kokkinos V. Expert-Level Intracranial Electroencephalogram Ictal Pattern Detection by a Deep Learning Neural Network. Front Neurol. 2021; 12:603868. PMID: 34012415.
    Citations: 1     
  15. Kokkinos V, Selviaridis P, Seimenis I. Feasibility, Contrast Sensitivity and Network Specificity of Language fMRI in Presurgical Evaluation for Epilepsy and Brain Tumor Surgery. Brain Topogr. 2021 07; 34(4):511-524. PMID: 33837867.
    Citations: 1     Fields:    Translation:Humans
  16. Venkatesh P, Sneider D, Danish M, Sisterson ND, Zaher N, Urban A, Grover P, Richardson RM, Kokkinos V. Quantifying a frequency modulation response biomarker in responsive neurostimulation. J Neural Eng. 2021 03 30; 18(4). PMID: 33691289.
    Citations:    Fields:    Translation:Humans
  17. Kokkinos V, Urban A, Sisterson ND, Li N, Corson D, Richardson RM. Responsive Neurostimulation of the Thalamus Improves Seizure Control in Idiopathic Generalized Epilepsy: A Case Report. Neurosurgery. 2020 10 15; 87(5):E578-E583. PMID: 32023343.
    Citations: 13     Fields:    Translation:Humans
  18. Zaher N, Urban A, Antony A, Plummer C, Bagic A, Richardson RM, Kokkinos V. Ictal Onset Signatures Predict Favorable Outcomes of Laser Thermal Ablation for Mesial Temporal Lobe Epilepsy. Front Neurol. 2020; 11:595454. PMID: 33178129.
    Citations: 2     
  19. Faraji AH, Kokkinos V, Sweat JC, Crammond DJ, Richardson RM. Robotic-Assisted Stereotaxy for Deep Brain Stimulation Lead Implantation in Awake Patients. Oper Neurosurg (Hagerstown). 2020 Sep 15; 19(4):444-452. PMID: 32147722.
    Citations: 7     Fields:    Translation:Humans
  20. Sisterson ND, Kokkinos V. Neuromodulation of Epilepsy Networks. Neurosurg Clin N Am. 2020 Jul; 31(3):459-470. PMID: 32475493.
    Citations: 6     Fields:    Translation:Humans
  21. Kokkinos V, Richardson RM. Preface. Neurosurg Clin N Am. 2020 07; 31(3):xiii-xiv. PMID: 32475495.
    Citations:    Fields:    Translation:Humans
  22. Sisterson ND, Wozny TA, Kokkinos V, Bagic A, Urban AP, Richardson RM. A Rational Approach to Understanding and Evaluating Responsive Neurostimulation. Neuroinformatics. 2020 06; 18(3):365-375. PMID: 31919656; PMCID: PMC7338816.
    Citations: 5     Fields:    Translation:Humans
  23. Kokkinos V. Interpretation of the Intracranial Stereoelectroencephalography Signal. Neurosurg Clin N Am. 2020 Jul; 31(3):421-433. PMID: 32475490.
    Citations:    Fields:    Translation:Humans
  24. Kokkinos V, Richardson RM, Urban A. The Hippocampal Barque: An Epileptiform but Non-epileptic Hippocampal Entity. Front Hum Neurosci. 2020; 14:92. PMID: 32256330; PMCID: PMC7093588.
    Citations:    
  25. Garganis K, Kokkinos V, Zountsas B, Dinopoulos A, Coras R, Blümcke I. Temporal lobe "plus" epilepsy associated with oligodendroglial hyperplasia (MOGHE). Acta Neurol Scand. 2019 Oct; 140(4):296-300. PMID: 31231790.
    Citations: 2     Fields:    Translation:HumansCells
  26. Kokkinos V, Sisterson ND, Wozny TA, Richardson RM. Association of Closed-Loop Brain Stimulation Neurophysiological Features With Seizure Control Among Patients With Focal Epilepsy. JAMA Neurol. 2019 07 01; 76(7):800-808. PMID: 30985902; PMCID: PMC6583077.
    Citations: 20     Fields:    Translation:Humans
  27. Kokkinos V, Zaher N, Antony A, Bagic A, Mark Richardson R, Urban A. The intracranial correlate of the 14&6/sec positive spikes normal scalp EEG variant. Clin Neurophysiol. 2019 09; 130(9):1570-1580. PMID: 31302567.
    Citations: 1     Fields:    Translation:Humans
  28. Kokkinos V, Vulliémoz S, Koupparis AM, Koutroumanidis M, Kostopoulos GK, Lemieux L, Garganis K. A hemodynamic network involving the insula, the cingulate, and the basal forebrain correlates with EEG synchronization phases of sleep instability. Sleep. 2019 04 01; 42(4). PMID: 30566659.
    Citations: 3     Fields:    Translation:Humans
  29. Boumpa E, Gkogkidis A, Charalampou I, Ntaliani A, Kakarountas A, Kokkinos V. An Acoustic-Based Smart Home System for People Suffering from Dementia. Technologies. 2019; 1(7):29. View Publication.
  30. Sisterson ND, Wozny TA, Kokkinos V, Constantino A, Richardson RM. Closed-Loop Brain Stimulation for Drug-Resistant Epilepsy: Towards an Evidence-Based Approach to Personalized Medicine. Neurotherapeutics. 2019 01; 16(1):119-127. PMID: 30378004.
    Citations: 18     Fields:    Translation:Humans
  31. Blumcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfäfflin M, Elger C, Widman G, Schramm J, Becker A, Braun KP, Leijten F, Baayen JC, Aronica E, Chassoux F, Hamer H, Stefan H, Rössler K, Thom M, Walker MC, Sisodiya SM, Duncan JS, McEvoy AW, Pieper T, Holthausen H, Kudernatsch M, Meencke HJ, Kahane P, Schulze-Bonhage A, Zentner J, Heiland DH, Urbach H, Steinhoff BJ, Bast T, Tassi L, Lo Russo G, Özkara C, Oz B, Krsek P, Vogelgesang S, Runge U, Lerche H, Weber Y, Honavar M, Pimentel J, Arzimanoglou A, Ulate-Campos A, Noachtar S, Hartl E, Schijns O, Guerrini R, Barba C, Jacques TS, Cross JH, Feucht M, Mühlebner A, Grunwald T, Trinka E, Winkler PA, Gil-Nagel A, Toledano Delgado R, Mayer T, Lutz M, Zountsas B, Garganis K, Rosenow F, Hermsen A, von Oertzen TJ, Diepgen TL, Avanzini G. Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. N Engl J Med. 2017 10 26; 377(17):1648-1656. PMID: 29069555.
    Citations: 145     Fields:    Translation:Humans
  32. Kokkinos V, Koupparis AM, Koutroumanidis M, Kostopoulos GK. Spatiotemporal propagation patterns of generalized ictal spikes in childhood absence epilepsy. Clin Neurophysiol. 2017 09; 128(9):1553-1562. PMID: 28709121.
    Citations: 4     Fields:    Translation:Humans
  33. Kokkinos V, Kallifatidis A, Kapsalaki EZ, Papanikolaou N, Garganis K. Thin isotropic FLAIR MR images at 1.5T increase the yield of focal cortical dysplasia transmantle sign detection in frontal lobe epilepsy. Epilepsy Res. 2017 05; 132:1-7. PMID: 28279892.
    Citations: 5     Fields:    Translation:Humans
  34. Sakellariou D, Koupparis AM, Kokkinos V, Koutroumanidis M, Kostopoulos GK. Connectivity Measures in EEG Microstructural Sleep Elements. Front Neuroinform. 2016; 10:5. PMID: 26924980; PMCID: PMC4756166.
    Citations: 3     
  35. Koupparis AM, Kokkinos V, Kostopoulos GK. Semi-automatic sleep EEG scoring based on the hypnospectrogram. J Neurosci Methods. 2014 Jan 15; 221:189-95. PMID: 24459717.
    Citations: 5     Fields:    Translation:Humans
  36. Garganis K, Kokkinos V, Zountsas B. EEG-fMRI findings in late seizure recurrence following temporal lobectomy: A possible contribution of area tempestas. Epilepsy Behav Case Rep. 2013; 1:157-60. PMID: 25667852; PMCID: PMC4150631.
    Citations: 1     
  37. Kokkinos V, Koupparis AM, Kostopoulos GK. An intra-K-complex oscillation with independent and labile frequency and topography in NREM sleep. Front Hum Neurosci. 2013; 7:163. PMID: 23637656.
    Citations: 8     
  38. Kokkinos V, Koupparis AM, Tsiptsios D, Kostopoulos GK, Koutroumanidis M. Spatiotemporal profiles of focal and generalised spikes in childhood absence epilepsy. Epileptic Disord. 2013 Mar; 15(1):14-26. PMID: 23702456.
    Citations: 1     Fields:    Translation:Humans
  39. Koupparis AM, Kokkinos V, Kostopoulos GK. Spindle power is not affected after spontaneous K-complexes during human NREM sleep. PLoS One. 2013; 8(1):e54343. PMID: 23326604.
    Citations: 2     Fields:    Translation:Humans
  40. Kokkinos V, Alarcón G, Selway RP, Valentín A. Role of single pulse electrical stimulation (SPES) to guide electrode implantation under general anaesthesia in presurgical assessment of epilepsy. Seizure. 2013 Apr; 22(3):198-204. PMID: 23298606.
    Citations: 4     Fields:    Translation:Humans
  41. Garganis K, Kokkinos V, Zountsas B. Surgical outcome in neocortical resections of type IIId focal cortical dysplasia with accompanying medial temporal pathology. Epilepsy Behav Case Rep. 2013; 1:29-31. PMID: 25688051; PMCID: PMC4150647.
    Citations: 1     
  42. Garganis K, Kokkinos V, Zountsas B. Extratemporal surface EEG features do not preclude successful surgical outcomes in drug-resistant epilepsy patients with unitemporal MRI lesions. Epileptic Disord. 2012 Sep; 14(3):275-89. PMID: 22944009.
    Citations:    Fields:    Translation:Humans
  43. Koutroumanidis M, Tsiptsios D, Kokkinos V, Kostopoulos GK. Focal and generalized EEG paroxysms in childhood absence epilepsy: topographic associations and distinctive behaviors during the first cycle of non-REM sleep. Epilepsia. 2012 May; 53(5):840-9. PMID: 22360352.
    Citations: 6     Fields:    Translation:Humans
  44. Kokkinos V, Zountsas B, Kontogiannis K, Garganis K. Epileptogenic networks in two patients with hypothalamic hamartoma. Brain Topogr. 2012 Jul; 25(3):327-31. PMID: 22207194.
    Citations: 5     Fields:    Translation:Humans
  45. Garganis K, Kokkinos V, Zountsas B. Limited resection of focal cortical dysplasia and associated epileptogenic cortex may lead to positive surgical outcome. Epileptic Disord. 2011 Dec; 13(4):422-9. PMID: 22258048.
    Citations: 1     Fields:    Translation:Humans
  46. Kokkinos V, Garganis K, Kontogiannis K, Zountsas B. Hemispherotomy or lobectomy? The role of presurgical neuroimaging in a young case of a large porencephalic cyst with intractable epilepsy. Pediatr Neurosurg. 2011; 47(3):204-9. PMID: 22122950.
    Citations: 6     Fields:    Translation:Humans
  47. Kokkinos V, Koupparis A, Stavrinou M, Garganis K, Kostopoulos G . Sleep spindle alterations following-up a childhood absence epilepsy case. Epileptologia. 2011; 2(19):73-83.
  48. Kokkinos V, Kostopoulos GK. Human non-rapid eye movement stage II sleep spindles are blocked upon spontaneous K-complex coincidence and resume as higher frequency spindles afterwards. J Sleep Res. 2011 Mar; 20(1 Pt 1):57-72. PMID: 20477951.
    Citations: 13     Fields:    Translation:Humans
  49. Chaudhary UJ, Kokkinos V, Carmichael DW, Rodionov R, Gasston D, Duncan JS, Lemieux L. Implementation and evaluation of simultaneous video-electroencephalography and functional magnetic resonance imaging. Magn Reson Imaging. 2010 Oct; 28(8):1192-9. PMID: 20233646.
    Citations: 3     Fields:    Translation:Humans
  50. Kokkinos V, Koutroumanidis M, Tsatsou K, Koupparis A, Tsiptsios D, Panayiotopoulos CP. Multifocal spatiotemporal distribution of interictal spikes in Panayiotopoulos syndrome. Clin Neurophysiol. 2010 Jun; 121(6):859-69. PMID: 20188626.
    Citations: 2     Fields:    Translation:Humans
  51. Koutroumanidis M, Tsiptsios D, Kokkinos V, Lysitsas K, Tsiropoulos I. Generalized spike-wave discharges and seizures with focal ictal transformation: mechanisms in absence (CAE) and myoclonic (JME) IGEs. Epilepsia. 2009 Oct; 50(10):2326-9. PMID: 19785670.
    Citations: 4     Fields:    Translation:Humans
  52. Kokkinos V, Koupparis A, Stavrinou ML, Kostopoulos GK. The hypnospectrogram: an EEG power spectrum based means to concurrently overview the macroscopic and microscopic architecture of human sleep. J Neurosci Methods. 2009 Dec 15; 185(1):29-38. PMID: 19747945.
    Citations: 5     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.