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Vasileios Kokkinos, Ph.D., Ph.D.

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Overview
Dr. Kokkinos received the diploma of Electrical & Computer Engineering and the MSc in Hardware-Software Integrated Systems from the Engineering School of the University of Patras, Greece, in 1998 and 2001. After working in the microelectronics industry, he shifted his interest towards the brain. In the graduate program of the Medical School of the University of Patras, Vasileios received the MSc in Basic Medical Sciences: Neurosciences in 2003, completing a thesis on the neurophysiology of the rat hippocampus. During the same period, he attended the undergraduate program of the Philosophy Department of the University of Patras, from which he graduated in 2005, with a thesis on neuroscience-derived theories of mind on visual perception. In the neurological sciences graduate program at McGill University, he then completed a thesis on the neurophysiology of human eye-head motor coordination, graduating in 2007.

Under the supervision of George K. Kostopoulos, MD, PhD, Dr. Kokkinos then joined the neurophysiology unit of the Medical School of the University of Patras and completed a PhD thesis on the neurophysiology of normal human sleep in 2010. One year of his PhD training (2008-09) was devoted to intense and highly specialized training in epilepsy at the UCL Institute of Neurology, in London. He completed a training/research fellowship on fMRI and EEG-fMRI for presurgical evaluation of epilepsy, under the supervision of John S. Duncan, MD, PhD, and Louis Lemieux, PhD. During the same time, he was accepted in the graduate course on epileptology at King’s College in London, from which he graduated in 2009 with distinction, completing a thesis on invasive electrical cortical stimulation for patients undergoing epilepsy surgery under the supervision of Gonzalo Alarcon, MD, PhD, and Antonio Valentin, MD, PhD. He also attended the research team of the Department of Clinical Neurophysiology and Epilepsies at St. Thomas’ Hospital in London where he was trained in pediatric and adult epileptic EEG by Chrysostomos P. Panayiotopoulos, MD, PhD, and Michalis Koutroumanidis, MD, PhD.

From 2009 to 2016, Dr. Kokkinos was head of neurophysiology and neuroimaging of the epilepsy program at St. Luke’s Hospital in Thessaloniki, Greece. His responsibilities in the pediatric and adult epilepsy program included the performance and supervision of procedures during both the non-invasive (video-EEG, MRI, fMRI, EEG-fMRI, DTI-tractography) and the invasive phases (acute and chronic ECoG, cortical electrical stimulation, neuronavigation) of the pre-surgical evaluation and surgical treatment protocol. From 2010 to 2017, Dr. Kokkinos also held a post-doctoral fellowship at the neurophysiology unit of the University of Patras Medical School under the mentorship of Dr. Kostopoulos, focusing on the neurophysiologic relations of sleep and epilepsy. He completed a second PhD thesis on neurophysiological features of focal and generalized epileptic syndromes of childhood in 2016.

In 2017, he was recruited by Mark Richardson, MD, PhD to the faculty of the University of Pittsburgh Department of Neurological Surgery as a Research Instructor and lead neurophysiologist for epilepsy research. Among other work, he discovered and published the first evidence for electrophysiological biomarkers of clinical response to RNS Therapy. Dr. Kokkinos is now the Brain Modulation Lab's faculty scientist for epilepsy research, as Instructor of Neurosurgery at Massachusetts General Hospital and Harvard Medical School, where he also provides extensive support to the clinical epilepsy surgery program.

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  1. Kokkinos V, Richardson RM. Preface. Neurosurg Clin N Am. 2020 Jul; 31(3):xiii-xiv. PMID: 32475495.
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  2. Sisterson ND, Kokkinos V. Neuromodulation of Epilepsy Networks. Neurosurg Clin N Am. 2020 Jul; 31(3):459-470. PMID: 32475493.
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  3. Sisterson ND, Wozny TA, Kokkinos V, Bagic A, Urban AP, Richardson RM. A Rational Approach to Understanding and Evaluating Responsive Neurostimulation. Neuroinformatics. 2020 Jun; 18(3):365-375. PMID: 31919656.
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  4. Kokkinos V. Interpretation of the Intracranial Stereoelectroencephalography Signal. Neurosurg Clin N Am. 2020 Jul; 31(3):421-433. PMID: 32475490.
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  5. Kokkinos V, Richardson RM, Urban A. The Hippocampal Barque: An Epileptiform but Non-epileptic Hippocampal Entity. Front Hum Neurosci. 2020; 14:92. PMID: 32256330.
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  6. Faraji AH, Kokkinos V, Sweat JC, Crammond DJ, Richardson RM. Robotic-Assisted Stereotaxy for Deep Brain Stimulation Lead Implantation in Awake Patients. Oper Neurosurg (Hagerstown). 2020 Mar 06. PMID: 32147722.
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  7. Kokkinos V, Urban A, Sisterson ND, Li N, Corson D, Richardson RM. Responsive Neurostimulation of the Thalamus Improves Seizure Control in Idiopathic Generalized Epilepsy: A Case Report. Neurosurgery. 2020 Feb 05. PMID: 32023343.
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  8. Garganis K, Kokkinos V, Zountsas B, Dinopoulos A, Coras R, Blümcke I. Temporal lobe "plus" epilepsy associated with oligodendroglial hyperplasia (MOGHE). Acta Neurol Scand. 2019 Oct; 140(4):296-300. PMID: 31231790.
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  9. Kokkinos V, Sisterson ND, Wozny TA, Richardson RM. Association of Closed-Loop Brain Stimulation Neurophysiological Features With Seizure Control Among Patients With Focal Epilepsy. JAMA Neurol. 2019 07 01; 76(7):800-808. PMID: 30985902.
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  10. Kokkinos V, Zaher N, Antony A, Bagic A, Mark Richardson R, Urban A. The intracranial correlate of the 14&6/sec positive spikes normal scalp EEG variant. Clin Neurophysiol. 2019 09; 130(9):1570-1580. PMID: 31302567.
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  11. Kokkinos V, Vulliémoz S, Koupparis AM, Koutroumanidis M, Kostopoulos GK, Lemieux L, Garganis K. A hemodynamic network involving the insula, the cingulate, and the basal forebrain correlates with EEG synchronization phases of sleep instability. Sleep. 2019 04 01; 42(4). PMID: 30566659.
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  12. Boumpa E, Gkogkidis A, Charalampou I, Ntaliani A, Kakarountas A, Kokkinos V. An Acoustic-Based Smart Home System for People Suffering from Dementia. Technologies. 2019; 1(7):29. View Publication.
  13. Sisterson ND, Wozny TA, Kokkinos V, Constantino A, Richardson RM. Closed-Loop Brain Stimulation for Drug-Resistant Epilepsy: Towards an Evidence-Based Approach to Personalized Medicine. Neurotherapeutics. 2019 01; 16(1):119-127. PMID: 30378004.
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  14. Blumcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfäfflin M, Elger C, Widman G, Schramm J, Becker A, Braun KP, Leijten F, Baayen JC, Aronica E, Chassoux F, Hamer H, Stefan H, Rössler K, Thom M, Walker MC, Sisodiya SM, Duncan JS, McEvoy AW, Pieper T, Holthausen H, Kudernatsch M, Meencke HJ, Kahane P, Schulze-Bonhage A, Zentner J, Heiland DH, Urbach H, Steinhoff BJ, Bast T, Tassi L, Lo Russo G, Özkara C, Oz B, Krsek P, Vogelgesang S, Runge U, Lerche H, Weber Y, Honavar M, Pimentel J, Arzimanoglou A, Ulate-Campos A, Noachtar S, Hartl E, Schijns O, Guerrini R, Barba C, Jacques TS, Cross JH, Feucht M, Mühlebner A, Grunwald T, Trinka E, Winkler PA, Gil-Nagel A, Toledano Delgado R, Mayer T, Lutz M, Zountsas B, Garganis K, Rosenow F, Hermsen A, von Oertzen TJ, Diepgen TL, Avanzini G. Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. N Engl J Med. 2017 10 26; 377(17):1648-1656. PMID: 29069555.
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  15. Kokkinos V, Koupparis AM, Koutroumanidis M, Kostopoulos GK. Spatiotemporal propagation patterns of generalized ictal spikes in childhood absence epilepsy. Clin Neurophysiol. 2017 09; 128(9):1553-1562. PMID: 28709121.
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  16. Kokkinos V, Kallifatidis A, Kapsalaki EZ, Papanikolaou N, Garganis K. Thin isotropic FLAIR MR images at 1.5T increase the yield of focal cortical dysplasia transmantle sign detection in frontal lobe epilepsy. Epilepsy Res. 2017 05; 132:1-7. PMID: 28279892.
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  17. Sakellariou D, Koupparis AM, Kokkinos V, Koutroumanidis M, Kostopoulos GK. Connectivity Measures in EEG Microstructural Sleep Elements. Front Neuroinform. 2016; 10:5. PMID: 26924980.
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  18. Koupparis AM, Kokkinos V, Kostopoulos GK. Semi-automatic sleep EEG scoring based on the hypnospectrogram. J Neurosci Methods. 2014 Jan 15; 221:189-95. PMID: 24459717.
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  19. Garganis K, Kokkinos V, Zountsas B. EEG-fMRI findings in late seizure recurrence following temporal lobectomy: A possible contribution of area tempestas. Epilepsy Behav Case Rep. 2013; 1:157-60. PMID: 25667852.
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  20. Kokkinos V, Koupparis AM, Kostopoulos GK. An intra-K-complex oscillation with independent and labile frequency and topography in NREM sleep. Front Hum Neurosci. 2013; 7:163. PMID: 23637656.
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  21. Kokkinos V, Koupparis AM, Tsiptsios D, Kostopoulos GK, Koutroumanidis M. Spatiotemporal profiles of focal and generalised spikes in childhood absence epilepsy. Epileptic Disord. 2013 Mar; 15(1):14-26. PMID: 23702456.
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  22. Koupparis AM, Kokkinos V, Kostopoulos GK. Spindle power is not affected after spontaneous K-complexes during human NREM sleep. PLoS One. 2013; 8(1):e54343. PMID: 23326604.
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  23. Kokkinos V, Alarcón G, Selway RP, Valentín A. Role of single pulse electrical stimulation (SPES) to guide electrode implantation under general anaesthesia in presurgical assessment of epilepsy. Seizure. 2013 Apr; 22(3):198-204. PMID: 23298606.
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  24. Garganis K, Kokkinos V, Zountsas B. Surgical outcome in neocortical resections of type IIId focal cortical dysplasia with accompanying medial temporal pathology. Epilepsy Behav Case Rep. 2013; 1:29-31. PMID: 25688051.
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  25. Garganis K, Kokkinos V, Zountsas B. Extratemporal surface EEG features do not preclude successful surgical outcomes in drug-resistant epilepsy patients with unitemporal MRI lesions. Epileptic Disord. 2012 Sep; 14(3):275-89. PMID: 22944009.
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  26. Koutroumanidis M, Tsiptsios D, Kokkinos V, Kostopoulos GK. Focal and generalized EEG paroxysms in childhood absence epilepsy: topographic associations and distinctive behaviors during the first cycle of non-REM sleep. Epilepsia. 2012 May; 53(5):840-9. PMID: 22360352.
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  27. Kokkinos V, Zountsas B, Kontogiannis K, Garganis K. Epileptogenic networks in two patients with hypothalamic hamartoma. Brain Topogr. 2012 Jul; 25(3):327-31. PMID: 22207194.
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  28. Garganis K, Kokkinos V, Zountsas B. Limited resection of focal cortical dysplasia and associated epileptogenic cortex may lead to positive surgical outcome. Epileptic Disord. 2011 Dec; 13(4):422-9. PMID: 22258048.
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  29. Kokkinos V, Garganis K, Kontogiannis K, Zountsas B. Hemispherotomy or lobectomy? The role of presurgical neuroimaging in a young case of a large porencephalic cyst with intractable epilepsy. Pediatr Neurosurg. 2011; 47(3):204-9. PMID: 22122950.
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  30. Kokkinos V, Koupparis A, Stavrinou M, Garganis K, Kostopoulos G . Sleep spindle alterations following-up a childhood absence epilepsy case. Epileptologia. 2011; 2(19):73-83.
  31. Kokkinos V, Kostopoulos GK. Human non-rapid eye movement stage II sleep spindles are blocked upon spontaneous K-complex coincidence and resume as higher frequency spindles afterwards. J Sleep Res. 2011 Mar; 20(1 Pt 1):57-72. PMID: 20477951.
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  32. Chaudhary UJ, Kokkinos V, Carmichael DW, Rodionov R, Gasston D, Duncan JS, Lemieux L. Implementation and evaluation of simultaneous video-electroencephalography and functional magnetic resonance imaging. Magn Reson Imaging. 2010 Oct; 28(8):1192-9. PMID: 20233646.
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  33. Kokkinos V, Koutroumanidis M, Tsatsou K, Koupparis A, Tsiptsios D, Panayiotopoulos CP. Multifocal spatiotemporal distribution of interictal spikes in Panayiotopoulos syndrome. Clin Neurophysiol. 2010 Jun; 121(6):859-69. PMID: 20188626.
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  34. Koutroumanidis M, Tsiptsios D, Kokkinos V, Lysitsas K, Tsiropoulos I. Generalized spike-wave discharges and seizures with focal ictal transformation: mechanisms in absence (CAE) and myoclonic (JME) IGEs. Epilepsia. 2009 Oct; 50(10):2326-9. PMID: 19785670.
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  35. Kokkinos V, Koupparis A, Stavrinou ML, Kostopoulos GK. The hypnospectrogram: an EEG power spectrum based means to concurrently overview the macroscopic and microscopic architecture of human sleep. J Neurosci Methods. 2009 Dec 15; 185(1):29-38. PMID: 19747945.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.