Harvard Catalyst Profiles

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Yuka Okusha, D.D.S.

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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Okusha Y, Murshid A, Calderwood SK. Proteotoxic stress-induced autophagy is regulated by the NRF2 pathway via extracellular vesicles. Cell Stress Chaperones. 2023 Feb 11. PMID: 36773174.
    Citations:    Fields:    
  2. Eguchi T, Okusha Y, Lu Y, Ono K, Taha EA, Fukuoka S. Comprehensive Method for Exosome Isolation and Proteome Analysis for Detection of CCN Factors in/on Exosomes. Methods Mol Biol. 2023; 2582:59-76. PMID: 36370344.
    Citations:    Fields:    Translation:Cells
  3. Eguchi T, Lu Y, Taha EA, Okusha Y. Transfection, Spinfection, Exofection, and Luciferase Assays for Analysis of CCN Genes Expression Mechanism. Methods Mol Biol. 2023; 2582:103-126. PMID: 36370347.
    Citations: 1     Fields:    Translation:Cells
  4. Okusha Y, Eguchi T. Protocol for CRISPR/Cas Genome Editing for Investigating Cell Communication Network. Methods Mol Biol. 2023; 2582:157-167. PMID: 36370349.
    Citations:    Fields:    
  5. Ono K, Okusha Y, Tran MT, Umemori K, Eguchi T. Western Blot Protocols for Analysis of CCN Proteins and Fragments in Exosomes, Vesicle-Free Fractions, and Cells. Methods Mol Biol. 2023; 2582:39-57. PMID: 36370343.
    Citations:    Fields:    Translation:Cells
  6. Prince TL, Lang BJ, Okusha Y, Eguchi T, Calderwood SK. Cdc37 as a Co-chaperone to Hsp90. Subcell Biochem. 2023; 101:141-158. PMID: 36520306.
    Citations:    Fields:    Translation:Cells
  7. Tran MT, Okusha Y, Htike K, Sogawa C, Eguchi T, Kadowaki T, Sakai E, Tsukuba T, Okamoto K. HSP90 drives the Rab11a-mediated vesicular transport of the cell surface receptors in osteoclasts. Cell Biochem Funct. 2022 Dec; 40(8):838-855. PMID: 36111708.
    Citations:    Fields:    Translation:HumansCells
  8. Okusha Y, Guerrero-Gimenez ME, Lang BJ, Borges TJ, Stevenson MA, Truman AW, Calderwood SK. MicroRNA-570 targets the HSP chaperone network, increases proteotoxic stress and inhibits mammary tumor cell migration. Sci Rep. 2022 09 16; 12(1):15582. PMID: 36114410; PMCID: PMC9481609.
    Citations: 1     Fields:    Translation:HumansCells
  9. Okusha Y, Lang BJ, Murshid A, Borges TJ, Holton KM, Clark-Matott J, Doshi S, Ikezu T, Calderwood SK. Publisher Correction: Extracellular Hsp90a stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress. Cell Stress Chaperones. 2022 Sep; 27(5):479-483. PMID: 35831741; PMCID: PMC9485317.
    Citations:    Fields:    
  10. Okusha Y, Lang BJ, Murshid A, Borges TJ, Holton KM, Clark-Matott J, Doshi S, Ikezu T, Calderwood SK. Extracellular Hsp90a stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress. Cell Stress Chaperones. 2022 09; 27(5):461-478. PMID: 35689138; PMCID: PMC9485360.
    Citations:    Fields:    
  11. Feng Y, Tran MT, Lu Y, Htike K, Okusha Y, Sogawa C, Eguchi T, Kadowaki T, Sakai E, Tsukuba T, Okamoto K. Rab34 plays a critical role as a bidirectional regulator of osteoclastogenesis. Cell Biochem Funct. 2022 Apr; 40(3):263-277. PMID: 35285960.
    Citations:    Fields:    Translation:AnimalsCells
  12. Lang BJ, Prince TL, Okusha Y, Bunch H, Calderwood SK. Heat shock proteins in cell signaling and cancer. Biochim Biophys Acta Mol Cell Res. 2022 03; 1869(3):119187. PMID: 34906617.
    Citations:    Fields:    Translation:HumansAnimalsCells
  13. Calderwood SK, Borges TJ, Eguchi T, Lang BJ, Murshid A, Okusha Y, Prince TL. Extracellular Hsp90 and protection of neuronal cells through Nrf2. Biochem Soc Trans. 2021 11 01; 49(5):2299-2306. PMID: 34415306.
    Citations: 1     Fields:    Translation:HumansCells
  14. Tran MT, Okusha Y, Feng Y, Sogawa C, Eguchi T, Kadowaki T, Sakai E, Tsukuba T, Okamoto K. A novel role of HSP90 in regulating osteoclastogenesis by abrogating Rab11b-driven transport. Biochim Biophys Acta Mol Cell Res. 2021 09; 1868(10):119096. PMID: 34242681.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Lang BJ, Guerrero ME, Prince TL, Okusha Y, Bonorino C, Calderwood SK. The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response. Arch Toxicol. 2021 06; 95(6):1943-1970. PMID: 34003342.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  16. Sogawa C, Eguchi T, Namba Y, Okusha Y, Aoyama E, Ohyama K, Okamoto K. Gel-Free 3D Tumoroids with Stem Cell Properties Modeling Drug Resistance to Cisplatin and Imatinib in Metastatic Colorectal Cancer. Cells. 2021 02 06; 10(2). PMID: 33562088.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Tran MT, Okusha Y, Feng Y, Morimatsu M, Wei P, Sogawa C, Eguchi T, Kadowaki T, Sakai E, Okamura H, Naruse K, Tsukuba T, Okamoto K. The Inhibitory Role of Rab11b in Osteoclastogenesis through Triggering Lysosome-Induced Degradation of c-Fms and RANK Surface Receptors. Int J Mol Sci. 2020 Dec 08; 21(24). PMID: 33302495.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Okusha Y, Tran MT, Itagaki M, Sogawa C, Eguchi T, Okui T, Kadowaki T, Sakai E, Tsukuba T, Okamoto K. Rab11A Functions as a Negative Regulator of Osteoclastogenesis through Dictating Lysosome-Induced Proteolysis of c-fms and RANK Surface Receptors. Cells. 2020 10 31; 9(11). PMID: 33142674; PMCID: PMC7692573.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  19. Ono K, Sogawa C, Kawai H, Tran MT, Taha EA, Lu Y, Oo MW, Okusha Y, Okamura H, Ibaragi S, Takigawa M, Kozaki KI, Nagatsuka H, Sasaki A, Okamoto K, Calderwood SK, Eguchi T. Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer. J Extracell Vesicles. 2020 May 31; 9(1):1769373. PMID: 33144925; PMCID: PMC7580842.
    Citations: 14     Fields:    
  20. Taha EA, Sogawa C, Okusha Y, Kawai H, Oo MW, Elseoudi A, Lu Y, Nagatsuka H, Kubota S, Satoh A, Okamoto K, Eguchi T. Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles. Cancers (Basel). 2020 05 16; 12(5). PMID: 32429403; PMCID: PMC7281240.
    Citations: 12     
  21. Okusha Y, Eguchi T, Tran MT, Sogawa C, Yoshida K, Itagaki M, Taha EA, Ono K, Aoyama E, Okamura H, Kozaki KI, Calderwood SK, Takigawa M, Okamoto K. Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer. Cancers (Basel). 2020 Apr 04; 12(4). PMID: 32260433; PMCID: PMC7226423.
    Citations: 9     
  22. Eguchi T, Sogawa C, Ono K, Matsumoto M, Tran MT, Okusha Y, Lang BJ, Okamoto K, Calderwood SK. Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells. Cells. 2020 03 19; 9(3). PMID: 32204513.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  23. Sogawa C, Eguchi T, Tran MT, Ishige M, Trin K, Okusha Y, Taha EA, Lu Y, Kawai H, Sogawa N, Takigawa M, Calderwood SK, Okamoto K, Kozaki KI. Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3. Cancers (Basel). 2020 Feb 24; 12(2). PMID: 32102440; PMCID: PMC7072357.
    Citations: 14     
  24. Sogawa C, Eguchi T, Okusha Y, Ono K, Ohyama K, Iizuka M, Kawasaki R, Hamada Y, Takigawa M, Sogawa N, Okamoto K, Kozaki KI. A Reporter System Evaluates Tumorigenesis, Metastasis, ß-catenin/MMP Regulation, and Druggability. Tissue Eng Part A. 2019 10; 25(19-20):1413-1425. PMID: 30734664.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  25. Hasegawa K, Okui T, Shimo T, Ibaragi S, Kawai H, Ryumon S, Kishimoto K, Okusha Y, Monsur Hassan NM, Sasaki A. Lactate Transporter Monocarboxylate Transporter 4 Induces Bone Pain in Head and Neck Squamous Cell Carcinoma. Int J Mol Sci. 2018 Oct 25; 19(11). PMID: 30366393.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  26. Namba Y, Sogawa C, Okusha Y, Kawai H, Itagaki M, Ono K, Murakami J, Aoyama E, Ohyama K, Asaumi JI, Takigawa M, Okamoto K, Calderwood SK, Kozaki KI, Eguchi T. Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells. Front Oncol. 2018; 8:376. PMID: 30364132; PMCID: PMC6191470.
    Citations: 22     
  27. Okusha Y, Eguchi T, Sogawa C, Okui T, Nakano K, Okamoto K, Kozaki KI. The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells. J Cell Biochem. 2018 09; 119(9):7363-7376. PMID: 29761931.
    Citations: 12     Fields:    Translation:AnimalsCells
  28. Eguchi T, Sogawa C, Okusha Y, Uchibe K, Iinuma R, Ono K, Nakano K, Murakami J, Itoh M, Arai K, Fujiwara T, Namba Y, Murata Y, Ohyama K, Shimomura M, Okamura H, Takigawa M, Nakatsura T, Kozaki KI, Okamoto K, Calderwood SK. Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment. PLoS One. 2018; 13(2):e0191109. PMID: 29415026.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  29. Morisawa A, Okui T, Shimo T, Ibaragi S, Okusha Y, Ono M, Nguyen TTH, Hassan NMM, Sasaki A. Ammonium tetrathiomolybdate enhances the antitumor effects of cetuximab via the suppression of osteoclastogenesis in head and neck squamous carcinoma. Int J Oncol. 2018 Mar; 52(3):989-999. PMID: 29328370.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  30. Okusha Y, Hirai Y, Maezawa H, Hisadome K, Inoue N, Yamazaki Y, Funahashi M. Effects of intraperitoneally administered L-histidine on food intake, taste, and visceral sensation in rats. J Physiol Sci. 2017 Jul; 67(4):467-474. PMID: 27535568.
    Citations: 2     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.