Harvard Catalyst Profiles

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Nabeel El-Bardeesy, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA235412 (MOSTOSLAVSKY, RAUL) Feb 19, 2019 - Jan 31, 2024
    NIH/NCI
    Mechanistic Understanding for the Role of Lin28b in Pancreatic Cancer Progression
    Role: Co-Principal Investigator
  2. R01CA219670 (EL-BARDEESY, NABEEL) Jul 11, 2018 - Jun 30, 2023
    NIH/NCI
    Targeting novel therapeutic vulnerabilities in LKB1 mutant tumors.
    Role: Principal Investigator
  3. R01CA215498 (EL-BARDEESY, NABEEL) Jan 1, 2018 - Dec 31, 2022
    NIH/NCI
    Functions of the LKB1 tumor suppressor in control in metabolism and epigenetics
    Role: Co-Principal Investigator
  4. R01CA136567 (AVRUCH, JOSEPH) Jul 6, 2010 - Apr 30, 2015
    NIH/NCI
    Decoding the MST1 and MST2 kinases in cellular physiology and tumor suppression
    Role: Co-Principal Investigator
  5. R01EB010023 (KELLY, KIMBERLY A.) Jul 1, 2010 - Mar 31, 2014
    NIH/NIBIB
    Development of Molecularly Targeted Imaging Agents for KRAS activity in vivo
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Benhamouche-Trouillet S, O'Loughlin E, Liu CH, Polacheck W, Fitamant J, McKee M, El-Bardeesy N, Chen CS, McClatchey AI. Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis. Development. 2018 04 30; 145(9). PMID: 29712669.
    Citations:    Fields:    Translation:Animals
  2. Hu Y, Zhang Z, Kashiwagi M, Yoshida T, Joshi I, Jena N, Somasundaram R, Emmanuel AO, Sigvardsson M, Fitamant J, El-Bardeesy N, Gounari F, Van Etten RA, Georgopoulos K. Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia. Genes Dev. 2016 09 01; 30(17):1971-90. PMID: 27664237.
    Citations: 11     Fields:    Translation:AnimalsCells
  3. Perera RM, Bardeesy N. Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up. Cancer Discov. 2015 Dec; 5(12):1247-61. PMID: 26534901.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  4. Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R. Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. PLoS Med. 2008 Apr 15; 5(4):e85. PMID: 18416599.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  5. Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, Wong KK. Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. Carcinogenesis. 2008 Apr; 29(4):747-53. PMID: 18283039.
    Citations: 18     Fields:    Translation:AnimalsCells
  6. Gurumurthy S, Hezel AF, Sahin E, Berger JH, Bosenberg MW, Bardeesy N. LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. Cancer Res. 2008 Jan 01; 68(1):55-63. PMID: 18172296.
    Citations: 35     Fields:    Translation:AnimalsCells
  7. Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood. 2008 Mar 15; 111(6):3236-44. PMID: 18096761.
    Citations: 95     Fields:    Translation:AnimalsCells
  8. Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Jänne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK. LKB1 modulates lung cancer differentiation and metastasis. Nature. 2007 Aug 16; 448(7155):807-10. PMID: 17676035.
    Citations: 354     Fields:    Translation:HumansAnimalsCells
  9. Berger JH, Bardeesy N. Modeling INK4/ARF tumor suppression in the mouse. Curr Mol Med. 2007 Feb; 7(1):63-75. PMID: 17311533.
    Citations: 9     Fields:    Translation:HumansAnimals
  10. Bardeesy N, Sharpless NE. RAS unplugged: negative feedback and oncogene-induced senescence. Cancer Cell. 2006 Dec; 10(6):451-3. PMID: 17157783.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  11. Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev. 2006 Nov 15; 20(22):3130-46. PMID: 17114584.
    Citations: 211     Fields:    Translation:AnimalsCells
  12. Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 2006 May 15; 20(10):1218-49. PMID: 16702400.
    Citations: 386     Fields:    Translation:HumansAnimals
  13. Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5947-52. PMID: 16585505.
    Citations: 206     Fields:    Translation:Animals
  14. Ji H, Houghton AM, Mariani TJ, Perera S, Kim CB, Padera R, Tonon G, McNamara K, Marconcini LA, Hezel A, El-Bardeesy N, Bronson RT, Sugarbaker D, Maser RS, Shapiro SD, Wong KK. K-ras activation generates an inflammatory response in lung tumors. Oncogene. 2006 Mar 30; 25(14):2105-12. PMID: 16288213.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  15. Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005 Dec 09; 310(5754):1642-6. PMID: 16308421.
    Citations: 558     Fields:    Translation:HumansAnimalsCells
  16. Bardeesy N, Kim M, Xu J, Kim RS, Shen Q, Bosenberg MW, Wong WH, Chin L. Role of epidermal growth factor receptor signaling in RAS-driven melanoma. Mol Cell Biol. 2005 May; 25(10):4176-88. PMID: 15870287.
    Citations: 15     Fields:    Translation:AnimalsCells
  17. Hezel AF, Bardeesy N, Maser RS. Telomere induced senescence: end game signaling. Curr Mol Med. 2005 Mar; 5(2):145-52. PMID: 15974867.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  18. Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR. Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 2004 Nov 01; 18(21):2614-26. PMID: 15489287.
    Citations: 116     Fields:    Translation:HumansAnimals
  19. Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 2004 Jul; 6(1):91-9. PMID: 15261145.
    Citations: 334     Fields:    Translation:AnimalsCells
  20. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2004 Jul 01; 18(13):1533-8. PMID: 15231735.
    Citations: 179     Fields:    Translation:HumansAnimalsCells
  21. Aguirre AJ, Brennan C, Bailey G, Sinha R, Feng B, Leo C, Zhang Y, Zhang J, Gans JD, Bardeesy N, Cauwels C, Cordon-Cardo C, Redston MS, DePinho RA, Chin L. High-resolution characterization of the pancreatic adenocarcinoma genome. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):9067-72. PMID: 15199222.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  22. Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3329-35. PMID: 14985505.
    Citations: 556     Fields:    Translation:HumansAnimalsCells
  23. Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, DePinho RA. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 2003 Dec 15; 17(24):3112-26. PMID: 14681207.
    Citations: 365     Fields:    Translation:HumansAnimalsCells
  24. Ossipova O, Bardeesy N, DePinho RA, Green JB. LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nat Cell Biol. 2003 Oct; 5(10):889-94. PMID: 12973359.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  25. Bardeesy N, DePinho RA. Pancreatic cancer biology and genetics. Nat Rev Cancer. 2002 Dec; 2(12):897-909. PMID: 12459728.
    Citations: 343     Fields:    Translation:HumansAnimals
  26. Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 2002 Sep 12; 419(6903):162-7. PMID: 12226664.
    Citations: 169     Fields:    Translation:AnimalsCells
  27. Bardeesy N, Morgan J, Sinha M, Signoretti S, Srivastava S, Loda M, Merlino G, DePinho RA. Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia. Mol Cell Biol. 2002 Jan; 22(2):635-43. PMID: 11756558.
    Citations: 19     Fields:    Translation:HumansAnimals
  28. Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature. 2001 Sep 06; 413(6851):86-91. PMID: 11544531.
    Citations: 246     Fields:    Translation:AnimalsCells
  29. Bardeesy N, Sharpless NE, DePinho RA, Merlino G. The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model. Semin Cancer Biol. 2001 Jun; 11(3):201-18. PMID: 11407945.
    Citations: 11     Fields:    Translation:Animals
  30. Martelli F, Hamilton T, Silver DP, Sharpless NE, Bardeesy N, Rokas M, DePinho RA, Livingston DM, Grossman SR. p19ARF targets certain E2F species for degradation. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4455-60. PMID: 11274364.
    Citations: 48     Fields:    Translation:HumansCells
  31. Bardeesy N, Bastian BC, Hezel A, Pinkel D, DePinho RA, Chin L. Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Mol Cell Biol. 2001 Mar; 21(6):2144-53. PMID: 11238948.
    Citations: 50     Fields:    Translation:AnimalsCells
  32. Bardeesy N, Wong KK, DePinho RA, Chin L. Animal models of melanoma: recent advances and future prospects. Adv Cancer Res. 2000; 79:123-56. PMID: 10818679.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  33. Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, Horner JW, Cordon-Cardo C, Yancopoulos GD, DePinho RA. Essential role for oncogenic Ras in tumour maintenance. Nature. 1999 Jul 29; 400(6743):468-72. PMID: 10440378.
    Citations: 229     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.