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Sheng Tony Hui, Ph.D.

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Biography
University of California San DiegoPhD2014Biophysics
Hong Kong Baptist UniversityMPhil2005Physics
Hong Kong Baptist UniversityBSc2002Physics

Overview
The Hui laboratory aims to answer fundamental questions of energy metabolism and the related diseases: How do individual tissues coordinate their metabolism to achieve overall energy balance of the body? Why can this balance be disrupted by certain perturbations, exhibiting as metabolic diseases (e.g., high-fat diet induces obesity and cancer causes cachexia)? What manipulations can we do to restore the energy balance thus reversing and preventing these diseases?

To answer these questions, we take the approach of in vivo flux quantification by integrating animal experiments, mass spectrometry, and quantitative modeling. Fluxes are the most fundamental functional property of metabolism. Their systematic quantitation holds the potential to transform the field of mammalian physiology. This approach, however, poses two key challenges: (i) need for diverse expertise: animal experiments, analytical chemistry, and mathematical modeling; and (ii) multiple time and length scales involved, from enzymes and their reaction kinetics up to the level of tissue and animal physiology. The lab is unique in having the combination of mathematical and biological skills to successfully tackle these challenges.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00DK117066 (HUI, SHENG) Apr 1, 2020 - Dec 31, 2022
    NIH
    Coordination of energy metabolism across individual tissues in mammals
    Role: Principal Investigator
  2. K99DK117066 (HUI, SHENG) Apr 1, 2018 - Mar 31, 2020
    NIH
    Coordination of energy metabolism across individual tissues in mammals
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.