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Sheng Tony Hui, Ph.D.

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University of California San DiegoPhD2014Biophysics
Hong Kong Baptist UniversityMPhil2005Physics
Hong Kong Baptist UniversityBSc2002Physics

The Hui laboratory aims to answer fundamental questions of energy metabolism and the related diseases: How do individual tissues coordinate their metabolism to achieve overall energy balance of the body? Why can this balance be disrupted by certain perturbations, exhibiting as metabolic diseases (e.g., high-fat diet induces obesity and cancer causes cachexia)? What manipulations can we do to restore the energy balance thus reversing and preventing these diseases?

To answer these questions, we take the approach of in vivo flux quantification by integrating animal experiments, mass spectrometry, and quantitative modeling. Fluxes are the most fundamental functional property of metabolism. Their systematic quantitation holds the potential to transform the field of mammalian physiology. This approach, however, poses two key challenges: (i) need for diverse expertise: animal experiments, analytical chemistry, and mathematical modeling; and (ii) multiple time and length scales involved, from enzymes and their reaction kinetics up to the level of tissue and animal physiology. The lab is unique in having the combination of mathematical and biological skills to successfully tackle these challenges.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00DK117066 (HUI, SHENG) Apr 1, 2020 - Dec 31, 2022
    Coordination of energy metabolism across individual tissues in mammals
    Role: Principal Investigator
  2. K99DK117066 (HUI, SHENG) Apr 1, 2018 - Mar 31, 2020
    Coordination of energy metabolism across individual tissues in mammals
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hui S, Cowan AJ, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz JD. Quantitative Fluxomics of Circulating Metabolites. Cell Metab. 2020 10 06; 32(4):676-688.e4. PMID: 32791100; PMCID: PMC7544659.
    Citations: 41     Fields:    Translation:AnimalsCells
  2. Jang C, Hui S, Zeng X, Cowan AJ, Wang L, Chen L, Morscher RJ, Reyes J, Frezza C, Hwang HY, Imai A, Saito Y, Okamoto K, Vaspoli C, Kasprenski L, Zsido GA, Gorman JH, Gorman RC, Rabinowitz JD. Metabolite Exchange between Mammalian Organs Quantified in Pigs. Cell Metab. 2019 09 03; 30(3):594-606.e3. PMID: 31257152; PMCID: PMC6726553.
    Citations: 50     Fields:    Translation:Animals
  3. Neinast MD, Jang C, Hui S, Murashige DS, Chu Q, Morscher RJ, Li X, Zhan L, White E, Anthony TG, Rabinowitz JD, Arany Z. Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids. Cell Metab. 2019 02 05; 29(2):417-429.e4. PMID: 30449684; PMCID: PMC6365191.
    Citations: 111     Fields:    Translation:AnimalsCells
  4. Jang C, Hui S, Lu W, Cowan AJ, Morscher RJ, Lee G, Liu W, Tesz GJ, Birnbaum MJ, Rabinowitz JD. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab. 2018 02 06; 27(2):351-361.e3. PMID: 29414685; PMCID: PMC6032988.
    Citations: 155     Fields:    Translation:Animals
  5. Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Yanxiang Guo J, White E, Rabinowitz JD. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017 11 02; 551(7678):115-118. PMID: 29045397.
    Citations: 398     Fields:    Translation:AnimalsCells
  6. Basan M, Hui S, Okano H, Zhang Z, Shen Y, Williamson JR, Hwa T. Overflow metabolism in Escherichia coli results from efficient proteome allocation. Nature. 2015 Dec 03; 528(7580):99-104. PMID: 26632588.
    Citations: 200     Fields:    Translation:Cells
  7. Hui S, Silverman JM, Chen SS, Erickson DW, Basan M, Wang J, Hwa T, Williamson JR. Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria. Mol Syst Biol. 2015 Feb 12; 11(1):784. PMID: 25678603.
    Citations: 108     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.