Harvard Catalyst Profiles

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Zhaohui Sunny Zhou, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM101396 (ZHOU, ZHAOHUI SUNNY) Jun 1, 2012 - Apr 30, 2016
    NIH/NIGMS
    Protein Modification: Isoaspartic Acid
    Role: Principal Investigator
  2. R01AI058146 (ZHOU, ZHAOHUI SUNNY) Jul 1, 2004 - Jun 30, 2010
    NIH/NIAID
    Mechanism and Inhibition for LuxS: A Biodefense Target
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sadiki A, Kercher EM, Lu H, Lang RT, Spring BQ, Zhou ZS. Site-specific Bioconjugation and Convergent Click Chemistry Enhances Antibody-Chromophore Conjugate Binding Efficiency. Photochem Photobiol. 2020 May; 96(3):596-603. PMID: 32080860.
    Citations:    
  2. Moulton KR, Sadiki A, Koleva BN, Ombelets LJ, Tran TH, Liu S, Wang B, Chen H, Micheloni E, Beuning PJ, O'Doherty GA, Zhou ZS. Site-Specific Reversible Protein and Peptide Modification: Transglutaminase-Catalyzed Glutamine Conjugation and Bioorthogonal Light-Mediated Removal. Bioconjug Chem. 2019 06 19; 30(6):1617-1621. PMID: 30945848.
    Citations:    
  3. Yang L, Chumsae C, Kaplan JB, Moulton KR, Wang D, Lee DH, Zhou ZS. Detection of Alkynes via Click Chemistry with a Brominated Coumarin Azide by Simultaneous Fluorescence and Isotopic Signatures in Mass Spectrometry. Bioconjug Chem. 2017 09 20; 28(9):2302-2309. PMID: 28825803.
    Citations:    
  4. Catcott KC, Yan J, Qu W, Wysocki VH, Zhou ZS. Identifying Unknown Enzyme-Substrate Pairs from the Cellular Milieu with Native Mass Spectrometry. Chembiochem. 2017 04 04; 18(7):613-617. PMID: 28140508.
    Citations:    
  5. Zang T, Pottenplackel LP, Handy DE, Loscalzo J, Dai S, Deth RC, Zhou ZS, Ma J. Comparison of Protein N-Homocysteinylation in Rat Plasma under Elevated Homocysteine Using a Specific Chemical Labeling Method. Molecules. 2016 Sep 08; 21(9). PMID: 27617989.
    Citations:    Fields:    Translation:AnimalsCells
  6. Qu W, Catcott KC, Zhang K, Liu S, Guo JJ, Ma J, Pablo M, Glick J, Xiu Y, Kenton N, Ma X, Duclos RI, Zhou ZS. Capturing Unknown Substrates via in Situ Formation of Tightly Bound Bisubstrate Adducts: S-Adenosyl-vinthionine as a Functional Probe for AdoMet-Dependent Methyltransferases. J Am Chem Soc. 2016 Mar 09; 138(9):2877-80. PMID: 26901520.
    Citations:    
  7. Liu S, Moulton KR, Auclair JR, Zhou ZS. Mildly acidic conditions eliminate deamidation artifact during proteolysis: digestion with endoprotease Glu-C at pH 4.5. Amino Acids. 2016 Apr; 48(4):1059-1067. PMID: 26748652.
    Citations:    
  8. Chumsae C, Hossler P, Raharimampionona H, Zhou Y, McDermott S, Racicot C, Radziejewski C, Zhou ZS. When Good Intentions Go Awry: Modification of a Recombinant Monoclonal Antibody in Chemically Defined Cell Culture by Xylosone, an Oxidative Product of Ascorbic Acid. Anal Chem. 2015 Aug 04; 87(15):7529-34. PMID: 26151084.
    Citations:    
  9. Duclos RI, Cleary DC, Catcott KC, Zhou ZS. Synthesis and characterization of Se-adenosyl-L-selenohomocysteine selenoxide. J Sulphur Chem. 2015 Apr 01; 36(2):135-144. PMID: 26005494.
    Citations:    
  10. Chumsae C, Zhou LL, Shen Y, Wohlgemuth J, Fung E, Burton R, Radziejewski C, Zhou ZS. Discovery of a chemical modification by citric acid in a recombinant monoclonal antibody. Anal Chem. 2014 Sep 16; 86(18):8932-6. PMID: 25136741.
    Citations:    
  11. Klaene JJ, Ni W, Alfaro JF, Zhou ZS. Detection and quantitation of succinimide in intact protein via hydrazine trapping and chemical derivatization. J Pharm Sci. 2014 Oct; 103(10):3033-42. PMID: 25043726.
    Citations:    
  12. Hodgson NW, Waly MI, Al-Farsi YM, Al-Sharbati MM, Al-Farsi O, Ali A, Ouhtit A, Zang T, Zhou ZS, Deth RC. Decreased glutathione and elevated hair mercury levels are associated with nutritional deficiency-based autism in Oman. Exp Biol Med (Maywood). 2014 Jun; 239(6):697-706. PMID: 24676906.
    Citations:    
  13. Liu M, Zhang Z, Cheetham J, Ren D, Zhou ZS. Discovery and characterization of a photo-oxidative histidine-histidine cross-link in IgG1 antibody utilizing ¹8O-labeling and mass spectrometry. Anal Chem. 2014 May 20; 86(10):4940-8. PMID: 24738698.
    Citations:    
  14. Chumsae C, Gifford K, Lian W, Liu H, Radziejewski CH, Zhou ZS. Arginine modifications by methylglyoxal: discovery in a recombinant monoclonal antibody and contribution to acidic species. Anal Chem. 2013 Dec 03; 85(23):11401-9. PMID: 24168114.
    Citations:    
  15. Liu M, Zhang Z, Zang T, Spahr C, Cheetham J, Ren D, Zhou ZS. Discovery of undefined protein cross-linking chemistry: a comprehensive methodology utilizing 18O-labeling and mass spectrometry. Anal Chem. 2013 Jun 18; 85(12):5900-8. PMID: 23634697.
    Citations:    
  16. Dai S, Ni W, Patananan AN, Clarke SG, Karger BL, Zhou ZS. Integrated proteomic analysis of major isoaspartyl-containing proteins in the urine of wild type and protein L-isoaspartate O-methyltransferase-deficient mice. Anal Chem. 2013 Feb 19; 85(4):2423-30. PMID: 23327623.
    Citations:    
  17. Gui S, Wooderchak-Donahue WL, Zang T, Chen D, Daly MP, Zhou ZS, Hevel JM. Substrate-induced control of product formation by protein arginine methyltransferase 1. Biochemistry. 2013 Jan 08; 52(1):199-209. PMID: 23214442.
    Citations:    
  18. Tiana S, Yu Q, Xin L, Zhou ZS, Upur H. Chemical fingerprinting by RP-RRLC-DAD and principal component analysis of Ziziphora clinopodioides from different locations. Nat Prod Commun. 2012 Sep; 7(9):1181-4. PMID: 23074902.
    Citations:    
  19. Liu M, Cheetham J, Cauchon N, Ostovic J, Ni W, Ren D, Zhou ZS. Protein isoaspartate methyltransferase-mediated 18O-labeling of isoaspartic acid for mass spectrometry analysis. Anal Chem. 2012 Jan 17; 84(2):1056-62. PMID: 22132761.
    Citations:    
  20. Kong P, Tyler BM, Richardson PA, Lee BW, Zhou ZS, Hong C. Zoospore interspecific signaling promotes plant infection by Phytophthora. BMC Microbiol. 2010 Dec 07; 10:313. PMID: 21138563.
    Citations:    
  21. Chen T, Nayak N, Majee SM, Lowenson J, Schäfermeyer KR, Eliopoulos AC, Lloyd TD, Dinkins R, Perry SE, Forsthoefel NR, Clarke SG, Vernon DM, Zhou ZS, Rejtar T, Downie AB. Substrates of the Arabidopsis thaliana protein isoaspartyl methyltransferase 1 identified using phage display and biopanning. J Biol Chem. 2010 Nov 26; 285(48):37281-92. PMID: 20870712.
    Citations:    
  22. Ni W, Dai S, Karger BL, Zhou ZS. Analysis of isoaspartic Acid by selective proteolysis with Asp-N and electron transfer dissociation mass spectrometry. Anal Chem. 2010 Sep 01; 82(17):7485-91. PMID: 20712325.
    Citations:    
  23. Liu M, Ronk M, Ren D, Ostovic J, Cauchon N, Zhou ZS, Cheetham J. Structure elucidation of highly polar basic degradants by on-line hydrogen/deuterium exchange hydrophilic interaction chromatography coupled to tandem mass spectrometry. J Chromatogr A. 2010 May 28; 1217(22):3598-611. PMID: 20417519.
    Citations:    
  24. Lee BW, Sun HG, Zang T, Kim BJ, Alfaro JF, Zhou ZS. Enzyme-catalyzed transfer of a ketone group from an S-adenosylmethionine analogue: a tool for the functional analysis of methyltransferases. J Am Chem Soc. 2010 Mar 24; 132(11):3642-3. PMID: 20196537.
    Citations:    
  25. Wang Z, Rejtar T, Zhou ZS, Karger BL. Desulfurization of cysteine-containing peptides resulting from sample preparation for protein characterization by mass spectrometry. Rapid Commun Mass Spectrom. 2010 Feb; 24(3):267-75. PMID: 20049891.
    Citations:    
  26. Kong P, Lee BW, Zhou ZS, Hong C. Zoosporic plant pathogens produce bacterial autoinducer-2 that affects Vibrio harveyi quorum sensing. FEMS Microbiol Lett. 2010 Feb; 303(1):55-60. PMID: 20002192.
    Citations:    
  27. Zang T, Dai S, Chen D, Lee BW, Liu S, Karger BL, Zhou ZS. Chemical methods for the detection of protein N-homocysteinylation via selective reactions with aldehydes. Anal Chem. 2009 Nov 01; 81(21):9065-71. PMID: 19874060.
    Citations:    
  28. Zang T, Lee BW, Cannon LM, Ritter KA, Dai S, Ren D, Wood TK, Zhou ZS. A naturally occurring brominated furanone covalently modifies and inactivates LuxS. Bioorg Med Chem Lett. 2009 Nov 01; 19(21):6200-4. PMID: 19775890.
    Citations: 19     Fields:    Translation:Animals
  29. Sadler JM, Mosley SL, Dorgan KM, Zhou ZS, Seley-Radtke KL. Synthetic strategies toward carbocyclic purine-pyrimidine hybrid nucleosides. Bioorg Med Chem. 2009 Aug 01; 17(15):5520-5. PMID: 19592260.
    Citations:    
  30. Wooderchak WL, Zhou ZS, Hevel J. Assays for S-adenosylmethionine (AdoMet/SAM)-dependent methyltransferases. Curr Protoc Toxicol. 2008 Nov; Chapter 4:Unit4.26. PMID: 23045008.
    Citations:    
  31. Wooderchak WL, Zang T, Zhou ZS, Acuña M, Tahara SM, Hevel JM. Substrate profiling of PRMT1 reveals amino acid sequences that extend beyond the "RGG" paradigm. Biochemistry. 2008 Sep 09; 47(36):9456-66. PMID: 18700728.
    Citations:    
  32. Alfaro JF, Gillies LA, Sun HG, Dai S, Zang T, Klaene JJ, Kim BJ, Lowenson JD, Clarke SG, Karger BL, Zhou ZS. Chemo-enzymatic detection of protein isoaspartate using protein isoaspartate methyltransferase and hydrazine trapping. Anal Chem. 2008 May 15; 80(10):3882-9. PMID: 18419136.
    Citations:    
  33. Biastoff S, Teuber M, Zhou ZS, Dräger B. Colorimetric activity measurement of a recombinant putrescine N-methyltransferase from Datura stramonium. Planta Med. 2006 Oct; 72(12):1136-41. PMID: 16924584.
    Citations:    
  34. Mosley SL, Bakke BA, Sadler JM, Sunkara NK, Dorgan KM, Zhou ZS, Seley-Radtke KL. Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase. Bioorg Med Chem. 2006 Dec 01; 14(23):7967-71. PMID: 16904326.
    Citations:    
  35. Dorgan KM, Wooderchak WL, Wynn DP, Karschner EL, Alfaro JF, Cui Y, Zhou ZS, Hevel JM. An enzyme-coupled continuous spectrophotometric assay for S-adenosylmethionine-dependent methyltransferases. Anal Biochem. 2006 Mar 15; 350(2):249-55. PMID: 16460659.
    Citations:    
  36. Alfaro JF, Zhang T, Wynn DP, Karschner EL, Zhou ZS. Synthesis of LuxS inhibitors targeting bacterial cell-cell communication. Org Lett. 2004 Sep 02; 6(18):3043-6. PMID: 15330583.
    Citations:    
  37. Hendricks CL, Ross JR, Pichersky E, Noel JP, Zhou ZS. An enzyme-coupled colorimetric assay for S-adenosylmethionine-dependent methyltransferases. Anal Biochem. 2004 Mar 01; 326(1):100-5. PMID: 14769341.
    Citations:    
  38. Wan W, Zhao G, Al-Saad K, Siems WF, Zhou ZS. Rapid screening for S-adenosylmethionine-dependent methylation products by enzyme-transferred isotope patterns analysis. Rapid Commun Mass Spectrom. 2004; 18(3):319-24. PMID: 14755618.
    Citations:    
  39. Zhao G, Wan W, Mansouri S, Alfaro JF, Bassler BL, Cornell KA, Zhou ZS. Chemical synthesis of S-ribosyl-L-homocysteine and activity assay as a LuxS substrate. Bioorg Med Chem Lett. 2003 Nov 17; 13(22):3897-900. PMID: 14592470.
    Citations:    
  40. Cannon LM, Butler FN, Wan W, Zhou ZS. A stereospecific colorimetric assay for (S,S)-adenosylmethionine quantification based on thiopurine methyltransferase-catalyzed thiol methylation. Anal Biochem. 2002 Sep 15; 308(2):358-63. PMID: 12419350.
    Citations: 8     Fields:    Translation:HumansCells
  41. Zhou ZS, Flohr A, Hilvert D. An Antibody-Catalyzed Allylic Sulfoxide-Sulfenate Rearrangement. J Org Chem. 1999 Oct 29; 64(22):8334-8341. PMID: 11674756.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.