Harvard Catalyst Profiles

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Siam Oottamasathien, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA227225 (GHANDEHARI, HAMID) Dec 1, 2018 - Nov 30, 2023
    Localized delivery of glycosaminoclycan ethers for the treatment of radiation-induced proctitis
    Role: Co-Investigator
  2. R01DK100868 (OOTTAMASATHIEN, SIAM) Sep 27, 2013 - Sep 26, 2014
    Treatment of Bladder Pain by Novel Glycosaminoglycan Derivatives
    Role: Principal Investigator
  3. R43DK093413 (SAVAGE, JUSTIN RODNEY) Sep 15, 2011 - Aug 30, 2013
    Novel Glycosaminoglycan Derivatives for Treatment of Bladder Inflammation
    Role: Co-Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Steinhauff D, Jensen MM, Griswold E, Jedrzkiewicz J, Cappello J, Oottamasathien S, Ghandehari H. An Oligomeric Sulfated Hyaluronan and Silk-Elastinlike Polymer Combination Protects against Murine Radiation Induced Proctitis. Pharmaceutics. 2022 Jan 12; 14(1). PMID: 35057068; PMCID: PMC8777937.
  2. Steinhauff D, Jensen M, Talbot M, Jia W, Isaacson K, Jedrzkiewicz J, Cappello J, Oottamasathien S, Ghandehari H. Silk-elastinlike copolymers enhance bioaccumulation of semisynthetic glycosaminoglycan ethers for prevention of radiation induced proctitis. J Control Release. 2021 04 10; 332:503-515. PMID: 33691185; PMCID: PMC9620761.
    Citations: 3     Fields:    Translation:HumansAnimals
  3. Jensen MM, Jia W, Schults AJ, Isaacson KJ, Steinhauff D, Green B, Zachary B, Cappello J, Ghandehari H, Oottamasathien S. Temperature-responsive silk-elastinlike protein polymer enhancement of intravesical drug delivery of a therapeutic glycosaminoglycan for treatment of interstitial cystitis/painful bladder syndrome. Biomaterials. 2019 10; 217:119293. PMID: 31276948; PMCID: PMC6638575.
    Citations: 10     Fields:    Translation:AnimalsCells
  4. Tao L, Tian S, Zhang J, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M. Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nat Microbiol. 2019 10; 4(10):1760-1769. PMID: 31160825; PMCID: PMC6754795.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  5. Lau G, Anderson R, Cartwright P, Wallis MC, Schaeffer A, Oottamasathien S, Snow B. Unilateral open extravesical ureteral reimplanation with contralateral dextronomer/hyaluronic acid injection performed as an outpatient therapy. J Pediatr Urol. 2018 12; 14(6):566.e1-566.e5. PMID: 30126744.
    Citations:    Fields:    Translation:Humans
  6. Martin Jensen M, Jia W, Schults AJ, Ye X, Prestwich GD, Oottamasathien S. IL-33 mast cell axis is central in LL-37 induced bladder inflammation and pain in a murine interstitial cystitis model. Cytokine. 2018 10; 110:420-427. PMID: 29784508.
    Citations: 9     Fields:    Translation:AnimalsCells
  7. Oottamasathien S, Hotaling JM, Craig JR, Myers JB, Brant WO. Amniotic therapeutic biomaterials in urology: current and future applications. Transl Androl Urol. 2017 Oct; 6(5):943-950. PMID: 29184795; PMCID: PMC5673810.
    Citations: 5     
  8. Jia W, Schults AJ, Jensen MM, Ye X, Alt JA, Prestwich GD, Oottamasathien S. Bladder pain in an LL-37 interstitial cystitis and painful bladder syndrome model. Am J Clin Exp Urol. 2017; 5(2):10-17. PMID: 29034266; PMCID: PMC5636891.
    Citations: 3     
  9. Schults AJ, Jia W, Ost MC, Oottamasathien S. Combination of Extracorporeal Shockwave Lithotripsy and Ureteroscopy for Large Staghorn Calculi in a Pediatric Patient: Case Report. J Endourol Case Rep. 2017; 3(1):64-66. PMID: 28616590; PMCID: PMC5467141.
    Citations: 1     
  10. Jensen MM, Jia W, Isaacson KJ, Schults A, Cappello J, Prestwich GD, Oottamasathien S, Ghandehari H. Silk-elastinlike protein polymers enhance the efficacy of a therapeutic glycosaminoglycan for prophylactic treatment of radiation-induced proctitis. J Control Release. 2017 Oct 10; 263:46-56. PMID: 28232224.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  11. Anderson RE, Hanson HA, Lowrance WT, Redshaw J, Oottamasathien S, Schaeffer A, Johnstone E, Aston KI, Carrell DT, Cartwright P, Smith KR, Hotaling JM. Childhood Cancer Risk in the Siblings and Cousins of Men with Poor Semen Quality. J Urol. 2017 03; 197(3 Pt 2):898-905. PMID: 28131504; PMCID: PMC5665568.
    Citations: 9     Fields:    Translation:Humans
  12. Pulsipher A, Qin X, Thomas AJ, Prestwich GD, Oottamasathien S, Alt JA. Prevention of sinonasal inflammation by a synthetic glycosaminoglycan. Int Forum Allergy Rhinol. 2017 02; 7(2):177-184. PMID: 27863138; PMCID: PMC5299046.
    Citations: 9     Fields:    Translation:Animals
  13. Alt JA, Qin X, Pulsipher A, Orb Q, Orlandi RR, Zhang J, Schults A, Jia W, Presson AP, Prestwich GD, Oottamasathien S. Topical cathelicidin (LL-37) an innate immune peptide induces acute olfactory epithelium inflammation in a mouse model. Int Forum Allergy Rhinol. 2015 Dec; 5(12):1141-50. PMID: 26346056.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  14. Summers SJ, Elliott S, McAdams S, Oottamasathien S, Brant WO, Presson AP, Fleck J, West J, Myers JB. Urologic problems in spina bifida patients transitioning to adult care. Urology. 2014 Aug; 84(2):440-4. PMID: 25065990.
    Citations: 16     Fields:    Translation:Humans
  15. Lee WY, Savage JR, Zhang J, Jia W, Oottamasathien S, Prestwich GD. Prevention of anti-microbial peptide LL-37-induced apoptosis and ATP release in the urinary bladder by a modified glycosaminoglycan. PLoS One. 2013; 8(10):e77854. PMID: 24204996; PMCID: PMC3813730.
    Citations: 19     Fields:    Translation:HumansAnimals
  16. Roundy LM, Jia W, Zhang J, Ye X, Prestwich GD, Oottamasathien S. LL-37 induced cystitis and the receptor for advanced glycation end-products (RAGE) pathway. Adv Biosci Biotechnol. 2013 Aug 01; 4(8B):1-8. PMID: 24883227.
    Citations: 5     
  17. Wallis MC, Oottamasathien S, Wicher C, Hadley D, Snow BW, Cartwright PC. Padded self-adhesive strap immobilization following newborn bladder exstrophy closure: the Utah straps. J Urol. 2013 Dec; 190(6):2216-20. PMID: 23810641.
    Citations: 1     Fields:    Translation:Humans
  18. Oottamasathien S, Jia W, Roundy LM, Zhang J, Wang L, Ye X, Hill AC, Savage J, Lee WY, Hannon AM, Milner S, Prestwich GD. Physiological relevance of LL-37 induced bladder inflammation and mast cells. J Urol. 2013 Oct; 190(4 Suppl):1596-1602. PMID: 23313203; PMCID: PMC3947931.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  19. Gabrielsen JS, Laciak RJ, Frank EL, McFadden M, Bates CS, Oottamasathien S, Hamilton BD, Wallis MC. Pediatric urinary stone composition in the United States. J Urol. 2012 Jun; 187(6):2182-7. PMID: 22503021.
    Citations: 11     Fields:    Translation:Humans
  20. Oottamasathien S, Jia W, McCoard L, Slack S, Zhang J, Skardal A, Job K, Kennedy TP, Dull RO, Prestwich GD. A murine model of inflammatory bladder disease: cathelicidin peptide induced bladder inflammation and treatment with sulfated polysaccharides. J Urol. 2011 Oct; 186(4 Suppl):1684-92. PMID: 21855919; PMCID: PMC3887035.
    Citations: 22     Fields:    Translation:Animals
  21. Pohl JF, Comstock JM, Oottamasathien S. Metastatic Crohn's disease of the penis in a pediatric patient. Inflamm Bowel Dis. 2011 Apr; 17(4):1056. PMID: 20645314.
    Citations:    Fields:    Translation:Humans
  22. Willis HL, Snow BW, Cartwright PC, Wallis MC, Oottamasathien S, deVries C. Parameatal urethral cysts in prepubertal males. J Urol. 2011 Mar; 185(3):1042-5. PMID: 21247599.
    Citations: 9     Fields:    Translation:Humans
  23. Skardal A, Zhang J, McCoard L, Oottamasathien S, Prestwich GD. Dynamically crosslinked gold nanoparticle - hyaluronan hydrogels. Adv Mater. 2010 Nov 09; 22(42):4736-40. PMID: 20730818.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  24. Skardal A, Zhang J, McCoard L, Xu X, Oottamasathien S, Prestwich GD. Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting. Tissue Eng Part A. 2010 Aug; 16(8):2675-85. PMID: 20387987.
    Citations: 100     Fields:    Translation:AnimalsCells
  25. Wicher C, Hadley D, Ludlow D, Oottamasathien S, Wallis MC, Devries C, Snow BW, Cartwright PC. 250 consecutive unilateral extravesical ureteral reimplantations in an outpatient setting. J Urol. 2010 Jul; 184(1):311-4. PMID: 20488495.
    Citations: 6     Fields:    Translation:Humans
  26. Thomas JC, Oottamasathien S, Makari JH, Honea L, Sharif-Afshar AR, Wang Y, Adams C, Wills ML, Bhowmick NA, Adams MC, Brock JW, Hayward SW, Matusik RJ, Pope JC. Temporal-spatial protein expression in bladder tissue derived from embryonic stem cells. J Urol. 2008 Oct; 180(4 Suppl):1784-9. PMID: 18721943.
    Citations: 9     Fields:    Translation:AnimalsCells
  27. Matusik RJ, Jin RJ, Sun Q, Wang Y, Yu X, Gupta A, Nandana S, Case TC, Paul M, Mirosevich J, Oottamasathien S, Thomas J. Prostate epithelial cell fate. Differentiation. 2008 Jul; 76(6):682-98. PMID: 18462434.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  28. Oottamasathien S, Williams K, Franco OE, Wills ML, Thomas JC, Sharif-Afshar AR, DeMarco RT, Brock JW, Bhowmick NA, Hayward SW, Pope JC. Urothelial inhibition of transforming growth factor-beta in a bladder tissue recombination model. J Urol. 2007 Oct; 178(4 Pt 2):1643-9. PMID: 17707033.
    Citations:    Fields:    Translation:AnimalsCells
  29. Oottamasathien S, Thomas JC, Adams MC, DeMarco RT, Brock JW, Pope JC. Testicular tumours in children: a single-institutional experience. BJU Int. 2007 May; 99(5):1123-6. PMID: 17437431.
    Citations: 11     Fields:    Translation:Humans
  30. Oottamasathien S, Wang Y, Williams K, Franco OE, Wills ML, Thomas JC, Saba K, Sharif-Afshar AR, Makari JH, Bhowmick NA, DeMarco RT, Hipkens S, Magnuson M, Brock JW, Hayward SW, Pope JC, Matusik RJ. Directed differentiation of embryonic stem cells into bladder tissue. Dev Biol. 2007 Apr 15; 304(2):556-66. PMID: 17289017; PMCID: PMC1994155.
    Citations: 31     Fields:    Translation:AnimalsCells
  31. Oottamasathien S, Wills ML, Brock JW, Pope JC. Primary extrarenal nephroblastomatosis. Urology. 2007 Jan; 69(1):184.e3-4. PMID: 17270650.
    Citations: 4     Fields:    Translation:Humans
  32. Oottamasathien S, Williams K, Franco OE, Thomas JC, Saba K, Bhowmick NA, Staack A, Demarco RT, Brock JW, Hayward SW, Pope JC. Bladder tissue formation from cultured bladder urothelium. Dev Dyn. 2006 Oct; 235(10):2795-801. PMID: 16804891.
    Citations: 10     Fields:    Translation:AnimalsCells
  33. Brant WO, Rajimwale A, Lovell MA, Travers SH, Furness PD, Sorensen M, Oottamasathien S, Koyle MA. Gonadoblastoma and Turner syndrome. J Urol. 2006 May; 175(5):1858-60. PMID: 16600779.
    Citations: 11     Fields:    Translation:Humans
  34. Koyle MA, Oottamasathien S, Barqawi A, Rajimwale A, Furness PD. Laparoscopic Palomo varicocele ligation in children and adolescents: results of 103 cases. J Urol. 2004 Oct; 172(4 Pt 2):1749-52; discussion 1752. PMID: 15371805.
    Citations: 8     Fields:    Translation:Humans
  35. Oottamasathien S, Crawford ED. Recent advances in hormonal therapy for advanced prostate cancer. Oncology (Williston Park). 2003 Aug; 17(8):1047-52; discussion 1054-8. PMID: 12966672.
    Citations:    Fields:    Translation:Humans
  36. Oottamasathien S, Crawford ED. Should routine screening for prostate-specific antigen be recommended? Arch Intern Med. 2003 Mar 24; 163(6):661-2; discussion 666. PMID: 12639195.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.