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Rosalba Siracusa, M.S.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fusco R, Siracusa R, Genovese T, Cuzzocrea S, Di Paola R. Focus on the Role of NLRP3 Inflammasome in Diseases. Int J Mol Sci. 2020 Jun 13; 21(12). PMID: 32545788.
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  2. Fusco R, Siracusa R, Peritore AF, Gugliandolo E, Genovese T, D'Amico R, Cordaro M, Crupi R, Mandalari G, Impellizzeri D, Cuzzocrea S, Di Paola R. The Role of Cashew (Anacardium occidentale L.) Nuts on an Experimental Model of Painful Degenerative Joint Disease. Antioxidants (Basel). 2020 Jun 10; 9(6). PMID: 32532064.
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  3. Peritore AF, Siracusa R, Fusco R, Gugliandolo E, D'Amico R, Cordaro M, Crupi R, Genovese T, Impellizzeri D, Cuzzocrea S, Di Paola R. Ultramicronized Palmitoylethanolamide and Paracetamol, a New Association to Relieve Hyperalgesia and Pain in a Sciatic Nerve Injury Model in Rat. Int J Mol Sci. 2020 May 15; 21(10). PMID: 32429243.
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  4. Crupi R, Palma E, Siracusa R, Fusco R, Gugliandolo E, Cordaro M, Impellizzeri D, De Caro C, Calzetta L, Cuzzocrea S, Di Paola R. Protective Effect of Hydroxytyrosol Against Oxidative Stress Induced by the Ochratoxin in Kidney Cells: in vitro and in vivo Study. Front Vet Sci. 2020; 7:136. PMID: 32296717.
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  5. Gugliandolo E, Palma E, Peritore AF, Siracusa R, D'Amico R, Fusco R, Licata P, Crupi R. Effect of Artesunate on Leishmania Amazonesis Induced Neuroinflammation and Nociceptive Behavior in Male Balb/C Mice. Animals (Basel). 2020 Mar 27; 10(4). PMID: 32230725.
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  6. Siracusa R, Fusco R, Peritore AF, Cordaro M, D'Amico R, Genovese T, Gugliandolo E, Crupi R, Smeriglio A, Mandalari G, Cuzzocrea S, Di Paola R, Impellizzeri D. The Antioxidant and Anti-Inflammatory Properties of Anacardium occidentale L. Cashew Nuts in a Mouse Model of Colitis. Nutrients. 2020 Mar 20; 12(3). PMID: 32245085.
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  7. D'Amico R, Fusco R, Cordaro M, Siracusa R, Peritore AF, Gugliandolo E, Crupi R, Scuto M, Cuzzocrea S, Di Paola R, Impellizzeri D. Modulation of NLRP3 Inflammasome through Formyl Peptide Receptor 1 (Fpr-1) Pathway as a New Therapeutic Target in Bronchiolitis Obliterans Syndrome. Int J Mol Sci. 2020 Mar 20; 21(6). PMID: 32244997.
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  8. Impellizzeri D, Siracusa R, Cordaro M, Peritore AF, Gugliandolo E, D'amico R, Fusco R, Crupi R, Rizzarelli E, Cuzzocrea S, Vaccaro S, Pulicetta M, Greco V, Sciuto S, Schiavinato A, Messina L, Di Paola R. Protective effect of a new hyaluronic acid -carnosine conjugate on the modulation of the inflammatory response in mice subjected to collagen-induced arthritis. Biomed Pharmacother. 2020 May; 125:110023. PMID: 32092830.
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  9. Cordaro M, Scuto M, Siracusa R, D'amico R, Filippo Peritore A, Gugliandolo E, Fusco R, Crupi R, Impellizzeri D, Pozzebon M, Alfonsi D, Mattei N, Marcolongo G, Evangelista M, Cuzzocrea S, Di Paola R. Effect of N-palmitoylethanolamine-oxazoline on comorbid neuropsychiatric disturbance associated with inflammatory bowel disease. FASEB J. 2020 Mar; 34(3):4085-4106. PMID: 31950563.
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  10. Crupi R, Gugliandolo E, Siracusa R, Impellizzeri D, Cordaro M, Di Paola R, Britti D, Cuzzocrea S. N-acetyl-L-cysteine reduces Leishmania amazonensis-induced inflammation in BALB/c mice. BMC Vet Res. 2020 Jan 13; 16(1):13. PMID: 31931804.
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  11. Peritore AF, Crupi R, Scuto M, Gugliandolo E, Siracusa R, Impellizzeri D, Cordaro M, D'amico R, Fusco R, Di Paola R, Cuzzocrea S. The Role of Annexin A1 and Formyl Peptide Receptor 2/3 Signaling in Chronic Corticosterone-Induced Depression-Like behaviors and Impairment in Hippocampal-Dependent Memory. CNS Neurol Disord Drug Targets. 2020; 19(1):27-43. PMID: 31914916.
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  12. Akki R, Siracusa R, Cordaro M, Remigante A, Morabito R, Errami M, Marino A. Adaptation to oxidative stress at cellular and tissue level. Arch Physiol Biochem. 2019 Dec 13; 1-11. PMID: 31835914.
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  13. Fusco R, Siracusa R, D'Amico R, Peritore AF, Cordaro M, Gugliandolo E, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R. Melatonin Plus Folic Acid Treatment Ameliorates Reserpine-Induced Fibromyalgia: An Evaluation of Pain, Oxidative Stress, and Inflammation. Antioxidants (Basel). 2019 Dec 06; 8(12). PMID: 31817734.
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  14. Rapa SF, Waltenberger B, Di Paola R, Adesso S, Siracusa R, Peritore AF, D'Amico R, Autore G, Cuzzocrea S, Stuppner H, Marzocco S. Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo. FASEB J. 2020 01; 34(1):1576-1590. PMID: 31914614.
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  15. Crupi R, Impellizzeri D, Gugliandolo E, Cordaro M, Siracusa R, Britti D, Cuzzocrea S, Di Paola R. Effect of Tempol, a Membrane-Permeable Free Radical Scavenger, on In Vitro Model of Eye Inflammation on Rabbit Corneal Cells. J Ocul Pharmacol Ther. 2019 12; 35(10):571-577. PMID: 31825758.
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  16. Cordaro M, Siracusa R, Impellizzeri D, D' Amico R, Peritore AF, Crupi R, Gugliandolo E, Fusco R, Di Paola R, Schievano C, Cuzzocrea S. Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain. Arthritis Res Ther. 2019 11 28; 21(1):254. PMID: 31779692.
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  17. Fusco R, Scuto M, Cordaro M, D'Amico R, Gugliandolo E, Siracusa R, Peritore AF, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R. N-Palmitoylethanolamide-Oxazoline Protects against Middle Cerebral Artery Occlusion Injury in Diabetic Rats by Regulating the SIRT1 Pathway. Int J Mol Sci. 2019 Sep 29; 20(19). PMID: 31569558.
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  18. Siracusa R, Fusco R, Cuzzocrea S. Astrocytes: Role and Functions in Brain Pathologies. Front Pharmacol. 2019; 10:1114. PMID: 31611796.
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  19. Peritore AF, Siracusa R, Crupi R, Cuzzocrea S. Therapeutic Efficacy of Palmitoylethanolamide and Its New Formulations in Synergy with Different Antioxidant Molecules Present in Diets. Nutrients. 2019 Sep 11; 11(9). PMID: 31514292.
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  20. Impellizzeri D, Peritore AF, Cordaro M, Gugliandolo E, Siracusa R, Crupi R, D'Amico R, Fusco R, Evangelista M, Cuzzocrea S, Di Paola R. The neuroprotective effects of micronized PEA (PEA-m) formulation on diabetic peripheral neuropathy in mice. FASEB J. 2019 10; 33(10):11364-11380. PMID: 31344333.
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  21. Campolo M, Siracusa R, Cordaro M, Filippone A, Gugliandolo E, Peritore AF, Impellizzeri D, Crupi R, Paterniti I, Cuzzocrea S. The association of adelmidrol with sodium hyaluronate displays beneficial properties against bladder changes following spinal cord injury in mice. PLoS One. 2019; 14(1):e0208730. PMID: 30653511.
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  22. Impellizzeri D, Siracusa R, Cordaro M, Crupi R, Peritore AF, Gugliandolo E, D'Amico R, Petrosino S, Evangelista M, Di Paola R, Cuzzocrea S. N-Palmitoylethanolamine-oxazoline (PEA-OXA): A new therapeutic strategy to reduce neuroinflammation, oxidative stress associated to vascular dementia in an experimental model of repeated bilateral common carotid arteries occlusion. Neurobiol Dis. 2019 05; 125:77-91. PMID: 30660740.
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  23. Lunardelli ML, Crupi R, Siracusa R, Cocuzza G, Cordaro M, Martini E, Impellizzeri D, Di Paola R, Cuzzocrea S. Co-ultraPEALut: Role in Preclinical and Clinical Delirium Manifestations. CNS Neurol Disord Drug Targets. 2019; 18(7):530-554. PMID: 31244434.
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  24. Campolo M, Paterniti I, Siracusa R, Filippone A, Esposito E, Cuzzocrea S. TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson's diseases in vivo model. Brain Behav Immun. 2019 02; 76:236-247. PMID: 30550933.
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  25. D'amico R, Fusco R, Gugliandolo E, Cordaro M, Siracusa R, Impellizzeri D, Peritore AF, Crupi R, Cuzzocrea S, Di Paola R. Effects of a new compound containing Palmitoylethanolamide and Baicalein in myocardial ischaemia/reperfusion injury in vivo. Phytomedicine. 2019 Feb 15; 54:27-42. PMID: 30668378.
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  26. Gugliandolo E, D'amico R, Cordaro M, Fusco R, Siracusa R, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R. Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush. J Neuroinflammation. 2018 Sep 14; 15(1):264. PMID: 30217164.
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  27. Siracusa R, Impellizzeri D, Cordaro M, Gugliandolo E, Peritore AF, Di Paola R, Cuzzocrea S. Topical Application of Adelmidrol + Trans-Traumatic Acid Enhances Skin Wound Healing in a Streptozotocin-Induced Diabetic Mouse Model. Front Pharmacol. 2018; 9:871. PMID: 30190675.
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  28. Fusco R, D'amico R, Cordaro M, Gugliandolo E, Siracusa R, Peritore AF, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R. Absence of formyl peptide receptor 1 causes endometriotic lesion regression in a mouse model of surgically-induced endometriosis. Oncotarget. 2018 Jul 31; 9(59):31355-31366. PMID: 30140375.
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  29. Gugliandolo E, D'Amico R, Cordaro M, Fusco R, Siracusa R, Crupi R, Impellizzeri D, Cuzzocrea S, Di Paola R. Neuroprotective Effect of Artesunate in Experimental Model of Traumatic Brain Injury. Front Neurol. 2018; 9:590. PMID: 30108544.
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  30. Impellizzeri D, Siracusa R, Cordaro M, Peritore AF, Gugliandolo E, Mancuso G, Midiri A, Di Paola R, Cuzzocrea S. Therapeutic potential of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice by targeting IL-1ß and IL-18. Biochem Pharmacol. 2018 09; 155:150-161. PMID: 29963998.
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  31. Ostardo E, Impellizzeri D, Cervigni M, Porru D, Sommariva M, Cordaro M, Siracusa R, Fusco R, Gugliandolo E, Crupi R, Schievano C, Inferrera A, Di Paola R, Cuzzocrea S. Adelmidrol + sodium hyaluronate in IC/BPS or conditions associated to chronic urothelial inflammation. A translational study. Pharmacol Res. 2018 08; 134:16-30. PMID: 29800607.
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  32. Paterniti I, Campolo M, Cordaro M, Siracusa R, Filippone A, Esposito E, Cuzzocrea S. Effects of different natural extracts in an experimental model of benign prostatic hyperplasia (BPH). Inflamm Res. 2018 Jul; 67(7):617-626. PMID: 29679313.
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  33. Cordaro M, Siracusa R, Crupi R, Impellizzeri D, Peritore AF, D'Amico R, Gugliandolo E, Di Paola R, Cuzzocrea S. 2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease. Mol Neurobiol. 2018 Dec; 55(12):9251-9266. PMID: 29656363.
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  34. Petrosino S, Cordaro M, Verde R, Schiano Moriello A, Marcolongo G, Schievano C, Siracusa R, Piscitelli F, Peritore AF, Crupi R, Impellizzeri D, Esposito E, Cuzzocrea S, Di Marzo V. Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect. Front Pharmacol. 2018; 9:249. PMID: 29615912.
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  35. Crupi R, Impellizzeri D, Cordaro M, Siracusa R, Casili G, Evangelista M, Cuzzocrea S. N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice. Mol Neurobiol. 2018 Nov; 55(11):8455-8472. PMID: 29552727.
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  36. Akki R, Siracusa R, Morabito R, Remigante A, Campolo M, Errami M, La Spada G, Cuzzocrea S, Marino A. Neuronal-like differentiated SH-SY5Y cells adaptation to a mild and transient H2 O2 -induced oxidative stress. Cell Biochem Funct. 2018 Mar; 36(2):56-64. PMID: 29431194.
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  37. Impellizzeri D, Cordaro M, Bruschetta G, Siracusa R, Crupi R, Esposito E, Cuzzocrea S. N-Palmitoylethanolamine-Oxazoline as a New Therapeutic Strategy to Control Neuroinflammation: Neuroprotective Effects in Experimental Models of Spinal Cord and Brain Injury. J Neurotrauma. 2017 09 15; 34(18):2609-2623. PMID: 28095731.
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  38. Paterniti I, Impellizzeri D, Cordaro M, Siracusa R, Bisignano C, Gugliandolo E, Carughi A, Esposito E, Mandalari G, Cuzzocrea S. The Anti-Inflammatory and Antioxidant Potential of Pistachios (Pistacia vera L.) In Vitro and In Vivo. Nutrients. 2017 Aug 22; 9(8). PMID: 28829406.
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  39. Cordaro M, Impellizzeri D, Siracusa R, Gugliandolo E, Fusco R, Inferrera A, Esposito E, Di Paola R, Cuzzocrea S. Effects of a co-micronized composite containing palmitoylethanolamide and polydatin in an experimental model of benign prostatic hyperplasia. Toxicol Appl Pharmacol. 2017 08 15; 329:231-240. PMID: 28610993.
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  40. Siracusa R, Impellizzeri D, Cordaro M, Crupi R, Esposito E, Petrosino S, Cuzzocrea S. Anti-Inflammatory and Neuroprotective Effects of Co-UltraPEALut in a Mouse Model of Vascular Dementia. Front Neurol. 2017; 8:233. PMID: 28634464.
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  41. Petrosino S, Campolo M, Impellizzeri D, Paterniti I, Allarà M, Gugliandolo E, D'Amico R, Siracusa R, Cordaro M, Esposito E, Di Marzo V, Cuzzocrea S. 2-Pentadecyl-2-Oxazoline, the Oxazoline of Pea, Modulates Carrageenan-Induced Acute Inflammation. Front Pharmacol. 2017; 8:308. PMID: 28611664.
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  42. Paterniti I, Campolo M, Siracusa R, Cordaro M, Di Paola R, Calabrese V, Navarra M, Cuzzocrea S, Esposito E. Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease. PLoS One. 2017; 12(4):e0174470. PMID: 28369131.
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  43. Siracusa R, Paterniti I, Cordaro M, Crupi R, Bruschetta G, Campolo M, Cuzzocrea S, Esposito E. Neuroprotective Effects of Temsirolimus in Animal Models of Parkinson's Disease. Mol Neurobiol. 2018 03; 55(3):2403-2419. PMID: 28357809.
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  44. Bertolino B, Crupi R, Impellizzeri D, Bruschetta G, Cordaro M, Siracusa R, Esposito E, Cuzzocrea S. Beneficial Effects of Co-Ultramicronized Palmitoylethanolamide/Luteolin in a Mouse Model of Autism and in a Case Report of Autism. CNS Neurosci Ther. 2017 Jan; 23(1):87-98. PMID: 27701827.
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  45. Cordaro M, Impellizzeri D, Gugliandolo E, Siracusa R, Crupi R, Esposito E, Cuzzocrea S. Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease. Mol Pharmacol. 2016 Nov; 90(5):549-561. PMID: 27625036.
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  46. Di Paola R, Cordaro M, Crupi R, Siracusa R, Campolo M, Bruschetta G, Fusco R, Pugliatti P, Esposito E, Cuzzocrea S. Protective Effects of Ultramicronized Palmitoylethanolamide (PEA-um) in Myocardial Ischaemia and Reperfusion Injury in VIVO. Shock. 2016 08; 46(2):202-13. PMID: 26844976.
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  47. Di Paola R, Impellizzeri D, Fusco R, Cordaro M, Siracusa R, Crupi R, Esposito E, Cuzzocrea S. Ultramicronized palmitoylethanolamide (PEA-um(®)) in the treatment of idiopathic pulmonary fibrosis. Pharmacol Res. 2016 09; 111:405-412. PMID: 27402190.
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  48. Impellizzeri D, Bruschetta G, Cordaro M, Crupi R, Siracusa R, Esposito E, Cuzzocrea S. Erratum to: Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain. J Neuroinflammation. 2016 May 31; 13(1):129. PMID: 27245980.
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  49. Cordaro M, Paterniti I, Siracusa R, Impellizzeri D, Esposito E, Cuzzocrea S. KU0063794, a Dual mTORC1 and mTORC2 Inhibitor, Reduces Neural Tissue Damage and Locomotor Impairment After Spinal Cord Injury in Mice. Mol Neurobiol. 2017 05; 54(4):2415-2427. PMID: 26960330.
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  50. Crupi R, Impellizzeri D, Bruschetta G, Cordaro M, Paterniti I, Siracusa R, Cuzzocrea S, Esposito E. Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord Injury. Front Pharmacol. 2016; 7:47. PMID: 27014061.
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  51. Paterniti I, Di Paola R, Campolo M, Siracusa R, Cordaro M, Bruschetta G, Tremolada G, Maestroni A, Bandello F, Esposito E, Zerbini G, Cuzzocrea S. Palmitoylethanolamide treatment reduces retinal inflammation in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2015 Dec 15; 769:313-23. PMID: 26607470.
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  52. Impellizzeri D, Talero E, Siracusa R, Alcaide A, Cordaro M, Maria Zubelia J, Bruschetta G, Crupi R, Esposito E, Cuzzocrea S, Motilva V. Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice. Br J Nutr. 2015 Sep 28; 114(6):853-65. PMID: 26334388.
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  53. Siracusa R, Paterniti I, Bruschetta G, Cordaro M, Impellizzeri D, Crupi R, Cuzzocrea S, Esposito E. The Association of Palmitoylethanolamide with Luteolin Decreases Autophagy in Spinal Cord Injury. Mol Neurobiol. 2016 08; 53(6):3783-3792. PMID: 26143261.
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  54. Impellizzeri D, Bruschetta G, Ahmad A, Crupi R, Siracusa R, Di Paola R, Paterniti I, Prosdocimi M, Esposito E, Cuzzocrea S. Effects of palmitoylethanolamide and silymarin combination treatment in an animal model of kidney ischemia and reperfusion. Eur J Pharmacol. 2015 Sep 05; 762:136-49. PMID: 25981305.
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  55. Cordaro M, Impellizzeri D, Paterniti I, Bruschetta G, Siracusa R, De Stefano D, Cuzzocrea S, Esposito E. Neuroprotective Effects of Co-UltraPEALut on Secondary Inflammatory Process and Autophagy Involved in Traumatic Brain Injury. J Neurotrauma. 2016 Jan 01; 33(1):132-46. PMID: 25046306.
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  56. Siracusa R, Paterniti I, Impellizzeri D, Cordaro M, Crupi R, Navarra M, Cuzzocrea S, Esposito E. The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson's Disease Model. CNS Neurol Disord Drug Targets. 2015; 14(10):1350-65. PMID: 26295827.
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  57. Impellizzeri D, Bruschetta G, Cordaro M, Crupi R, Siracusa R, Esposito E, Cuzzocrea S. Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain. J Neuroinflammation. 2014 Aug 28; 11:136. PMID: 25164769.
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  58. Paterniti I, Cordaro M, Campolo M, Siracusa R, Cornelius C, Navarra M, Cuzzocrea S, Esposito E. Neuroprotection by association of palmitoylethanolamide with luteolin in experimental Alzheimer's disease models: the control of neuroinflammation. CNS Neurol Disord Drug Targets. 2014; 13(9):1530-41. PMID: 25106636.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.