Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Tomas Leopold Kirchhausen, Ph.D.

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Other Positions
Title
Institution
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Mentoring
completed student projects
Secramine: Specificity and Inhibition of Cell Transformation
Summer, 06/27/05 - 08/19/05

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R35GM130386 (KIRCHHAUSEN, TOMAS) Mar 1, 2019 - Feb 29, 2024
    NIH/NIGMS
    VISUALIZATION OF SUBCELLULAR DYNAMICS IN MULTICELLULAR ORGANISMS
    Role: Principal Investigator
  2. U19AI109740 (WHELAN, SEAN PJ) Mar 1, 2014 - Feb 28, 2019
    NIH/NIAID
    Small molecule inhibitors of enveloped virus entry
    Role: Co-Principal Investigator
  3. R01GM075252 (KIRCHHAUSEN, TOMAS) Sep 10, 2005 - Sep 30, 2012
    NIH/NIGMS
    Dynamics of Clathrin Coat Formation in Cells
    Role: Principal Investigator
  4. U54AI057159 (KASPER, DENNIS L.) Sep 4, 2003 - Feb 29, 2008
    NIH/NIAID
    New England Regional Center of Excellence in Biodefense and Emerging Infectious D
    Role: Co-Principal Investigator
  5. P01GM062566 (MITCHISON, TIMOTHY J) Sep 30, 2000 - Aug 31, 2006
    NIH/NIGMS
    CHEMICAL GENETIC APPROACHES TO BASIC CELL BIOLOGY
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bloyet LM, Morin B, Brusic V, Gardner E, Ross RA, Vadakkan T, Kirchhausen T, Whelan SPJ. Oligomerization of the vesicular stomatitis virus phosphoprotein is dispensable for mRNA synthesis but facilitates RNA replication. J Virol. 2020 Apr 22. PMID: 32321813.
    Citations:    
  2. He K, Song E, Upadhyayula S, Dang S, Gaudin R, Skillern W, Bu K, Capraro BR, Rapoport I, Kusters I, Ma M, Kirchhausen T. Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic. J Cell Biol. 2020 Mar 02; 219(3). PMID: 31962345.
    Citations:    
  3. Hoffman DP, Shtengel G, Xu CS, Campbell KR, Freeman M, Wang L, Milkie DE, Pasolli HA, Iyer N, Bogovic JA, Stabley DR, Shirinifard A, Pang S, Peale D, Schaefer K, Pomp W, Chang CL, Lippincott-Schwartz J, Kirchhausen T, Solecki DJ, Betzig E, Hess HF. Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells. Science. 2020 01 17; 367(6475). PMID: 31949053.
    Citations:    
  4. Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S. Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling. Cell Rep. 2019 06 04; 27(10):3049-3061.e6. PMID: 31167147.
    Citations:    
  5. Calzoni E, Platt CD, Keles S, Kuehn HS, Beaussant-Cohen S, Zhang Y, Pazmandi J, Lanzi G, Pala F, Tahiat A, Artac H, Heredia RJ, Dmytrus J, Reisli I, Uygun V, Uygun D, Bingol A, Basaran E, Djenouhat K, Benhalla N, Bendahmane C, Emiroglu M, Kirchhausen T, Pasham M, Jones J, Wallace JG, Zheng L, Boisson B, Porta F, Rosenzweig SD, Su H, Giliani S, Lenardo M, Geha RS, Boztug K, Chou J, Notarangelo LD. F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects. J Allergy Clin Immunol. 2019 Jun; 143(6):2317-2321.e12. PMID: 30822429.
    Citations:    
  6. Gao R, Asano SM, Upadhyayula S, Pisarev I, Milkie DE, Liu TL, Singh V, Graves A, Huynh GH, Zhao Y, Bogovic J, Colonell J, Ott CM, Zugates C, Tappan S, Rodriguez A, Mosaliganti KR, Sheu SH, Pasolli HA, Pang S, Xu CS, Megason SG, Hess H, Lippincott-Schwartz J, Hantman A, Rubin GM, Kirchhausen T, Saalfeld S, Aso Y, Boyden ES, Betzig E. Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution. Science. 2019 01 18; 363(6424). PMID: 30655415.
    Citations:    Fields:    
  7. Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA. The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Rep. 2018 07 24; 24(4):973-986.e8. PMID: 30044992.
    Citations:    Fields:    
  8. Swinburne IA, Mosaliganti KR, Upadhyayula S, Liu TL, Hildebrand DGC, Tsai TY, Chen A, Al-Obeidi E, Fass AK, Malhotra S, Engert F, Lichtman JW, Kirchhausen T, Betzig E, Megason SG. Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure. Elife. 2018 06 19; 7. PMID: 29916365.
    Citations:    Fields:    
  9. Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E. Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science. 2018 04 20; 360(6386). PMID: 29674564.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  10. Böcking T, Upadhyayula S, Rapoport I, Capraro BR, Kirchhausen T. Reconstitution of Clathrin Coat Disassembly for Fluorescence Microscopy and Single-Molecule Analysis. Methods Mol Biol. 2018; 1847:121-146. PMID: 30129014.
    Citations:    Fields:    
  11. He K, Marsland R, Upadhyayula S, Song E, Dang S, Capraro BR, Wang W, Skillern W, Gaudin R, Ma M, Kirchhausen T. Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic. Nature. 2017 12 21; 552(7685):410-414. PMID: 29236694.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  12. Raaben M, Jae LT, Herbert AS, Kuehne AI, Stubbs SH, Chou YY, Blomen VA, Kirchhausen T, Dye JM, Brummelkamp TR, Whelan SP. NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry. Cell Host Microbe. 2017 Nov 08; 22(5):688-696.e5. PMID: 29120745.
    Citations: 2     Fields:    Translation:HumansCells
  13. Adell MAY, Migliano SM, Upadhyayula S, Bykov YS, Sprenger S, Pakdel M, Vogel GF, Jih G, Skillern W, Behrouzi R, Babst M, Schmidt O, Hess MW, Briggs JA, Kirchhausen T, Teis D. Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding. Elife. 2017 10 11; 6. PMID: 29019322.
    Citations: 5     Fields:    Translation:AnimalsCells
  14. Paulsen BS, Mandal PK, Frock RL, Boyraz B, Yadav R, Upadhyayula S, Gutierrez-Martinez P, Ebina W, Fasth A, Kirchhausen T, Talkowski ME, Agarwal S, Alt FW, Rossi DJ. Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing. Nat Biomed Eng. 2017 11; 1(11):878-888. PMID: 31015609.
    Citations:    
  15. Schuler MH, Lewandowska A, Caprio GD, Skillern W, Upadhyayula S, Kirchhausen T, Shaw JM, Cunniff B. Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration. Mol Biol Cell. 2017 Aug 01; 28(16):2159-2169. PMID: 28615318.
    Citations: 5     Fields:    Translation:AnimalsCells
  16. Chou YY, Krupp A, Kaynor C, Gaudin R, Ma M, Cahir-McFarland E, Kirchhausen T. Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9. Sci Rep. 2016 11 14; 6:36921. PMID: 27841295.
    Citations: 3     Fields:    Translation:HumansCells
  17. Hu Y, Kim JH, He K, Wan Q, Kim J, Flach M, Kirchhausen T, Vortkamp A, Winau F. Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion. J Exp Med. 2016 11 14; 213(12):2759-2772. PMID: 27810927.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  18. Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S. Membrane fission by dynamin: what we know and what we need to know. EMBO J. 2016 11 02; 35(21):2270-2284. PMID: 27670760.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  19. Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV. Seipin is required for converting nascent to mature lipid droplets. Elife. 2016 Aug 26; 5. PMID: 27564575.
    Citations: 20     Fields:    
  20. Aguet F, Upadhyayula S, Gaudin R, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, Megason S, Betzig E, Kirchhausen T. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Mol Biol Cell. 2016 11 07; 27(22):3418-3435. PMID: 27535432.
    Citations: 10     Fields:    Translation:AnimalsCells
  21. Chou YY, Cuevas C, Carocci M, Stubbs SH, Ma M, Cureton DK, Chao L, Evesson F, He K, Yang PL, Whelan SP, Ross SR, Kirchhausen T, Gaudin R. Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. J Virol. 2016 May; 90(9):4494-4510. PMID: 26912630.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  22. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. PMID: 26947396.
    Citations: 24     Fields:    
  23. Reeves PM, Kang YL, Kirchhausen T. Endocytosis of Ligand-Activated Sphingosine 1-Phosphate Receptor 1 Mediated by the Clathrin-Pathway. Traffic. 2016 Jan; 17(1):40-52. PMID: 26481905.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  24. Gaudin R, Kirchhausen T. Superinfection exclusion is absent during acute Junin virus infection of Vero and A549 cells. Sci Rep. 2015 Nov 09; 5:15990. PMID: 26549784.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  25. Li D, Shao L, Chen BC, Zhang X, Zhang M, Moses B, Milkie DE, Beach JR, Hammer JA, Pasham M, Kirchhausen T, Baird MA, Davidson MW, Xu P, Betzig E. ADVANCED IMAGING. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics. Science. 2015 Aug 28; 349(6251):aab3500. PMID: 26315442.
    Citations: 88     Fields:    Translation:AnimalsCells
  26. Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nat Biotechnol. 2015 Aug; 33(8):870-6. PMID: 26192320.
    Citations: 35     Fields:    Translation:HumansCells
  27. Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes. Cell. 2015 May 21; 161(5):1229. PMID: 28910642.
    Citations: 2     Fields:    
  28. Kural C, Akatay AA, Gaudin R, Chen BC, Legant WR, Betzig E, Kirchhausen T. Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells. Mol Biol Cell. 2015 Jun 01; 26(11):2044-53. PMID: 25851602.
    Citations: 10     Fields:    Translation:HumansCells
  29. Ishikawa Y, Maeda M, Pasham M, Aguet F, Tacheva-Grigorova SK, Masuda T, Yi H, Lee SU, Xu J, Teruya-Feldstein J, Ericsson M, Mullally A, Heuser J, Kirchhausen T, Maeda T. Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology. Haematologica. 2015 Apr; 100(4):439-51. PMID: 25552701.
    Citations: 6     Fields:    Translation:AnimalsCells
  30. Hagemann AI, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S. In vivo analysis of formation and endocytosis of the Wnt/ß-Catenin signaling complex in zebrafish embryos. J Cell Sci. 2014 Dec 15; 127(24):5331. PMID: 25512326.
    Citations:    
  31. Cocucci E, Gaudin R, Kirchhausen T. Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit. Mol Biol Cell. 2014 Nov 05; 25(22):3595-609. PMID: 25232009.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  32. Abdelhakim AH, Salgado EN, Fu X, Pasham M, Nicastro D, Kirchhausen T, Harrison SC. Structural correlates of rotavirus cell entry. PLoS Pathog. 2014 Sep; 10(9):e1004355. PMID: 25211455.
    Citations: 3     Fields:    Translation:AnimalsCells
  33. Hagemann AI, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S. In vivo analysis of formation and endocytosis of the Wnt/ß-catenin signaling complex in zebrafish embryos. J Cell Sci. 2014 Sep 15; 127(Pt 18):3970-82. PMID: 25074807.
    Citations: 15     Fields:    Translation:AnimalsCells
  34. Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes. Cell. 2014 Jun 05; 157(6):1309-23. PMID: 24906149.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  35. Böcking T, Aguet F, Rapoport I, Banzhaf M, Yu A, Zeeh JC, Kirchhausen T. Key interactions for clathrin coat stability. Structure. 2014 Jun 10; 22(6):819-29. PMID: 24815030.
    Citations: 6     Fields:    Translation:AnimalsCells
  36. Kirchhausen T, Owen D, Harrison SC. Molecular structure, function, and dynamics of clathrin-mediated membrane traffic. Cold Spring Harb Perspect Biol. 2014 May 01; 6(5):a016725. PMID: 24789820.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  37. Carmo-Fonseca M, Kirchhausen T. The timing of pre-mRNA splicing visualized in real-time. Nucleus. 2014 Jan-Feb; 5(1):11-4. PMID: 24637398.
    Citations:    Fields:    Translation:Cells
  38. Martin RM, Rino J, Carvalho C, Kirchhausen T, Carmo-Fonseca M. Live-cell visualization of pre-mRNA splicing with single-molecule sensitivity. Cell Rep. 2013 Sep 26; 4(6):1144-55. PMID: 24035393.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  39. Piccinotti S, Kirchhausen T, Whelan SP. Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin. J Virol. 2013 Nov; 87(21):11637-47. PMID: 23966407.
    Citations: 17     Fields:    Translation:AnimalsCells
  40. Tacheva-Grigorova SK, Santos AJ, Boucrot E, Kirchhausen T. Clathrin-mediated endocytosis persists during unperturbed mitosis. Cell Rep. 2013 Aug 29; 4(4):659-68. PMID: 23954786.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  41. Heesters BA, Chatterjee P, Kim YA, Gonzalez SF, Kuligowski MP, Kirchhausen T, Carroll MC. Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation. Immunity. 2013 Jun 27; 38(6):1164-75. PMID: 23770227.
    Citations: 55     Fields:    Translation:AnimalsCells
  42. Martinelli R, Kamei M, Sage PT, Massol R, Varghese L, Sciuto T, Toporsian M, Dvorak AM, Kirchhausen T, Springer TA, Carman CV. Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds. J Cell Biol. 2013 Apr 29; 201(3):449-65. PMID: 23629967.
    Citations: 27     Fields:    Translation:HumansCells
  43. Boulant S, Stanifer M, Kural C, Cureton DK, Massol R, Nibert ML, Kirchhausen T. Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2013 Apr; 24(8):1196-207. PMID: 23427267.
    Citations: 11     Fields:    Translation:AnimalsCells
  44. Lu L, Hannoush RN, Goess BC, Varadarajan S, Shair MD, Kirchhausen T. The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export. Mol Biol Cell. 2013 Apr; 24(7):1020-9. PMID: 23389632.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  45. Kural C, Tacheva-Grigorova SK, Boulant S, Cocucci E, Baust T, Duarte D, Kirchhausen T. Dynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers. Cell Rep. 2012 Nov 29; 2(5):1111-9. PMID: 23103167.
    Citations: 26     Fields:    Translation:AnimalsCells
  46. Kirchhausen T. Bending membranes. Nat Cell Biol. 2012 Sep; 14(9):906-8. PMID: 22945258.
    Citations: 26     Fields:    Translation:Cells
  47. Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M. Small molecule-mediated TGF-ß type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 03; 11(2):242-52. PMID: 22862949.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  48. Cocucci E, Aguet F, Boulant S, Kirchhausen T. The first five seconds in the life of a clathrin-coated pit. Cell. 2012 Aug 03; 150(3):495-507. PMID: 22863004.
    Citations: 93     Fields:    Translation:AnimalsCells
  49. Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S. Regulation of ligand-independent Notch signal through intracellular trafficking. Commun Integr Biol. 2012 Jul 01; 5(4):374-6. PMID: 23060962.
    Citations: 8     
  50. Cureton DK, Harbison CE, Cocucci E, Parrish CR, Kirchhausen T. Limited transferrin receptor clustering allows rapid diffusion of canine parvovirus into clathrin endocytic structures. J Virol. 2012 May; 86(9):5330-40. PMID: 22357278.
    Citations: 15     Fields:    Translation:AnimalsCells
  51. Strang BL, Boulant S, Kirchhausen T, Coen DM. Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments. mBio. 2012; 3(1). PMID: 22318319.
    Citations: 16     Fields:    Translation:HumansCells
  52. Kural C, Kirchhausen T. Live-cell imaging of clathrin coats. Methods Enzymol. 2012; 505:59-80. PMID: 22289448.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  53. Lu L, Kirchhausen T. Visualizing the high curvature regions of post-mitotic nascent nuclear envelope membrane. Commun Integr Biol. 2012 Jan 01; 5(1):16-8. PMID: 22482003.
    Citations: 2     
  54. Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S. Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol. 2011 Dec 12; 195(6):1005-15. PMID: 22162134.
    Citations: 35     Fields:    Translation:AnimalsCells
  55. Strang BL, Boulant S, Chang L, Knipe DM, Kirchhausen T, Coen DM. Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis. J Virol. 2012 Feb; 86(4):2089-95. PMID: 22156516.
    Citations: 17     Fields:    Translation:HumansCells
  56. Boulant S, Kural C, Zeeh JC, Ubelmann F, Kirchhausen T. Actin dynamics counteract membrane tension during clathrin-mediated endocytosis. Nat Cell Biol. 2011 Aug 14; 13(9):1124-31. PMID: 21841790.
    Citations: 141     Fields:    Translation:AnimalsCells
  57. Lu L, Ladinsky MS, Kirchhausen T. Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly. J Cell Biol. 2011 Aug 08; 194(3):425-40. PMID: 21825076.
    Citations: 40     Fields:    Translation:HumansCells
  58. Ivanovic T, Boulant S, Ehrlich M, Demidenko AA, Arnold MM, Kirchhausen T, Nibert ML. Recruitment of cellular clathrin to viral factories and disruption of clathrin-dependent trafficking. Traffic. 2011 Sep; 12(9):1179-95. PMID: 21736684.
    Citations: 12     Fields:    Translation:AnimalsCells
  59. Thiery J, Keefe D, Boulant S, Boucrot E, Walch M, Martinvalet D, Goping IS, Bleackley RC, Kirchhausen T, Lieberman J. Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol. 2011 Jun 19; 12(8):770-7. PMID: 21685908.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  60. Boucrot E, Howes MT, Kirchhausen T, Parton RG. Redistribution of caveolae during mitosis. J Cell Sci. 2011 Jun 15; 124(Pt 12):1965-72. PMID: 21625007.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  61. Bai M, Gad H, Turacchio G, Cocucci E, Yang JS, Li J, Beznoussenko GV, Nie Z, Luo R, Fu L, Collawn JF, Kirchhausen T, Luini A, Hsu VW. ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol. 2011 May; 13(5):559-67. PMID: 21499258.
    Citations: 14     Fields:    Translation:Humans
  62. Böcking T, Aguet F, Harrison SC, Kirchhausen T. Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating. Nat Struct Mol Biol. 2011 Mar; 18(3):295-301. PMID: 21278753.
    Citations: 37     Fields:    Translation:AnimalsCells
  63. Yu A, Xing Y, Harrison SC, Kirchhausen T. Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure. 2010 Oct 13; 18(10):1311-20. PMID: 20947020.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  64. Cureton DK, Massol RH, Whelan SP, Kirchhausen T. The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis. PLoS Pathog. 2010 Sep 30; 6(9):e1001127. PMID: 20941355.
    Citations: 48     Fields:    Translation:AnimalsCells
  65. Guan R, Dai H, Han D, Harrison SC, Kirchhausen T. Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding. Structure. 2010 Sep 08; 18(9):1191-8. PMID: 20826345.
    Citations: 20     Fields:    Translation:AnimalsCells
  66. Harrison SC, Kirchhausen T. Structural biology: Conservation in vesicle coats. Nature. 2010 Aug 26; 466(7310):1048-9. PMID: 20739998.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  67. Utskarpen A, Massol R, van Deurs B, Lauvrak SU, Kirchhausen T, Sandvig K. Shiga toxin increases formation of clathrin-coated pits through Syk kinase. PLoS One. 2010 Jul 27; 5(7):e10944. PMID: 20668539.
    Citations: 11     Fields:    Translation:HumansCells
  68. Boucrot E, Saffarian S, Zhang R, Kirchhausen T. Roles of AP-2 in clathrin-mediated endocytosis. PLoS One. 2010 May 12; 5(5):e10597. PMID: 20485680.
    Citations: 44     Fields:    Translation:HumansCells
  69. Anitei M, Stange C, Parshina I, Baust T, Schenck A, Raposo G, Kirchhausen T, Hoflack B. Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN. Nat Cell Biol. 2010 Apr; 12(4):330-40. PMID: 20228810.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  70. Smits P, Bolton AD, Funari V, Hong M, Boyden ED, Lu L, Manning DK, Dwyer ND, Moran JL, Prysak M, Merriman B, Nelson SF, Bonafé L, Superti-Furga A, Ikegawa S, Krakow D, Cohn DH, Kirchhausen T, Warman ML, Beier DR. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. N Engl J Med. 2010 Jan 21; 362(3):206-16. PMID: 20089971.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  71. Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, Kirchhausen T, Lieberman J. Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood. 2010 Feb 25; 115(8):1582-93. PMID: 20038786.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  72. Xing Y, Böcking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SC. Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly. EMBO J. 2010 Feb 03; 29(3):655-65. PMID: 20033059.
    Citations: 39     Fields:    Translation:AnimalsCells
  73. Kirchhausen T. Imaging endocytic clathrin structures in living cells. Trends Cell Biol. 2009 Nov; 19(11):596-605. PMID: 19836955.
    Citations: 62     Fields:    Translation:HumansAnimals
  74. Saffarian S, Cocucci E, Kirchhausen T. Distinct dynamics of endocytic clathrin-coated pits and coated plaques. PLoS Biol. 2009 Sep; 7(9):e1000191. PMID: 19809571.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  75. Lu L, Ladinsky MS, Kirchhausen T. Cisternal organization of the endoplasmic reticulum during mitosis. Mol Biol Cell. 2009 Aug; 20(15):3471-80. PMID: 19494040.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  76. Cureton DK, Massol RH, Saffarian S, Kirchhausen TL, Whelan SP. Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization. PLoS Pathog. 2009 Apr; 5(4):e1000394. PMID: 19390604.
    Citations: 119     Fields:    Translation:Cells
  77. Shulman Z, Shinder V, Klein E, Grabovsky V, Yeger O, Geron E, Montresor A, Bolomini-Vittori M, Feigelson SW, Kirchhausen T, Laudanna C, Shakhar G, Alon R. Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity. 2009 Mar 20; 30(3):384-96. PMID: 19268609.
    Citations: 81     Fields:    Translation:HumansCells
  78. Ambrogio C, Voena C, Manazza AD, Martinengo C, Costa C, Kirchhausen T, Hirsch E, Inghirami G, Chiarle R. The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation. Cancer Res. 2008 Nov 01; 68(21):8899-907. PMID: 18974134.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  79. Boucrot E, Kirchhausen T. Mammalian cells change volume during mitosis. PLoS One. 2008 Jan 23; 3(1):e1477. PMID: 18213385.
    Citations: 31     Fields:    Translation:AnimalsCells
  80. Kirchhausen T, Macia E, Pelish HE. Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods Enzymol. 2008; 438:77-93. PMID: 18413242.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  81. Nieland TJ, Shaw JT, Jaipuri FA, Duffner JL, Koehler AN, Banakos S, Zannis VI, Kirchhausen T, Krieger M. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 08; 47(1):460-72. PMID: 18067275.
    Citations: 12     Fields:    Translation:HumansCells
  82. Veiga E, Guttman JA, Bonazzi M, Boucrot E, Toledo-Arana A, Lin AE, Enninga J, Pizarro-Cerdá J, Finlay BB, Kirchhausen T, Cossart P. Invasive and adherent bacterial pathogens co-Opt host clathrin for infection. Cell Host Microbe. 2007 Nov 15; 2(5):340-51. PMID: 18005755.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  83. Saffarian S, Kirchhausen T. Differential evanescence nanometry: live-cell fluorescence measurements with 10-nm axial resolution on the plasma membrane. Biophys J. 2008 Mar 15; 94(6):2333-42. PMID: 17993495.
    Citations: 45     Fields:    Translation:AnimalsCells
  84. Rapoport I, Boll W, Yu A, Böcking T, Kirchhausen T. A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction. Mol Biol Cell. 2008 Jan; 19(1):405-13. PMID: 17978091.
    Citations: 21     Fields:    Translation:AnimalsCells
  85. Jiang S, Zhou X, Kirchhausen T, Wong ST. Tracking molecular particles in live cells using fuzzy rule-based system. Cytometry A. 2007 Aug; 71(8):576-84. PMID: 17542029.
    Citations: 3     Fields:    Translation:Animals
  86. Jiang S, Zhou X, Kirchhausen T, Wong ST. Detection of molecular particles in live cells via machine learning. Cytometry A. 2007 Aug; 71(8):563-75. PMID: 17431884.
    Citations: 7     Fields:    Translation:AnimalsCells
  87. Li J, Peters PJ, Bai M, Dai J, Bos E, Kirchhausen T, Kandror KV, Hsu VW. An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol. 2007 Jul 30; 178(3):453-64. PMID: 17664335.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  88. Kirchhausen T. Making COPII coats. Cell. 2007 Jun 29; 129(7):1251-2. PMID: 17604713.
    Citations: 3     Fields:    Translation:AnimalsCells
  89. Wang J, Sun HQ, Macia E, Kirchhausen T, Watson H, Bonifacino JS, Yin HL. PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal. Mol Biol Cell. 2007 Jul; 18(7):2646-55. PMID: 17494868.
    Citations: 58     Fields:    Translation:HumansCells
  90. Boucrot E, Kirchhausen T. Endosomal recycling controls plasma membrane area during mitosis. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):7939-44. PMID: 17483462.
    Citations: 115     Fields:    Translation:HumansCells
  91. Ma YM, Boucrot E, Villén J, Affar el B, Gygi SP, Göttlinger HG, Kirchhausen T. Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. J Biol Chem. 2007 Mar 30; 282(13):9805-12. PMID: 17261583.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  92. Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X, Kirchhausen T. Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling. Dev Cell. 2007 Jan; 12(1):129-41. PMID: 17199046.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  93. Xu B, Pelish H, Kirchhausen T, Hammond GB. Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading. Org Biomol Chem. 2006 Nov 21; 4(22):4149-57. PMID: 17312971.
    Citations: 12     Fields:    Translation:AnimalsCells
  94. Newton AJ, Kirchhausen T, Murthy VN. Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17955-60. PMID: 17093049.
    Citations: 97     Fields:    Translation:AnimalsCells
  95. Falcone S, Cocucci E, Podini P, Kirchhausen T, Clementi E, Meldolesi J. Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events. J Cell Sci. 2006 Nov 15; 119(Pt 22):4758-69. PMID: 17077125.
    Citations: 68     Fields:    Translation:HumansCells
  96. Cheng Y, Boll W, Kirchhausen T, Harrison SC, Walz T. Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol. 2007 Jan 19; 365(3):892-9. PMID: 17095010.
    Citations: 35     Fields:    Translation:AnimalsCells
  97. Boucrot E, Saffarian S, Massol R, Kirchhausen T, Ehrlich M. Role of lipids and actin in the formation of clathrin-coated pits. Exp Cell Res. 2006 Dec 10; 312(20):4036-48. PMID: 17097636.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  98. Fotin A, Kirchhausen T, Grigorieff N, Harrison SC, Walz T, Cheng Y. Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. J Struct Biol. 2006 Dec; 156(3):453-60. PMID: 16908193.
    Citations: 15     Fields:    Translation:Cells
  99. Massol RH, Boll W, Griffin AM, Kirchhausen T. A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10265-10270. PMID: 16798879.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  100. Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006 Jun; 10(6):839-50. PMID: 16740485.
    Citations: 686     Fields:    Translation:HumansCells
  101. Goess BC, Hannoush RN, Chan LK, Kirchhausen T, Shair MD. Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors. J Am Chem Soc. 2006 Apr 26; 128(16):5391-403. PMID: 16620111.
    Citations: 12     Fields:    Translation:Cells
  102. Pelish HE, Ciesla W, Tanaka N, Reddy K, Shair MD, Kirchhausen T, Lencer WI. The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells. Biochem Pharmacol. 2006 Jun 14; 71(12):1720-6. PMID: 16677615.
    Citations: 6     Fields:    Translation:HumansCells
  103. Pelish HE, Peterson JR, Salvarezza SB, Rodriguez-Boulan E, Chen JL, Stamnes M, Macia E, Feng Y, Shair MD, Kirchhausen T. Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol. 2006 Jan; 2(1):39-46. PMID: 16408091.
    Citations: 58     Fields:    Translation:AnimalsCells
  104. Keefe D, Shi L, Feske S, Massol R, Navarro F, Kirchhausen T, Lieberman J. Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity. 2005 Sep; 23(3):249-62. PMID: 16169498.
    Citations: 87     Fields:    Translation:HumansCells
  105. McNeil PL, Kirchhausen T. An emergency response team for membrane repair. Nat Rev Mol Cell Biol. 2005 Jun; 6(6):499-505. PMID: 15928713.
    Citations: 131     Fields:    Translation:AnimalsCells
  106. Paleotti O, Macia E, Luton F, Klein S, Partisani M, Chardin P, Kirchhausen T, Franco M. The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes. J Biol Chem. 2005 Jun 03; 280(22):21661-6. PMID: 15802264.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  107. Massol RH, Larsen JE, Kirchhausen T. Possible role of deep tubular invaginations of the plasma membrane in MHC-I trafficking. Exp Cell Res. 2005 May 15; 306(1):142-9. PMID: 15878340.
    Citations: 7     Fields:    Translation:HumansCells
  108. Nieland TJ, Ehrlich M, Krieger M, Kirchhausen T. Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI. Biochim Biophys Acta. 2005 May 01; 1734(1):44-51. PMID: 15866482.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  109. Kirchhausen T, Boll W, van Oijen A, Ehrlich M. Single-molecule live-cell imaging of clathrin-based endocytosis. Biochem Soc Symp. 2005; (72):71-6. PMID: 15649131.
    Citations: 5     Fields:    Translation:AnimalsCells
  110. Benedito AB, Lehtinen M, Massol R, Lopes UG, Kirchhausen T, Rao A, Bonni A. The transcription factor NFAT3 mediates neuronal survival. J Biol Chem. 2005 Jan 28; 280(4):2818-25. PMID: 15537643.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  111. Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 02; 432(7017):573-9. PMID: 15502812.
    Citations: 150     Fields:    Translation:AnimalsCells
  112. Fotin A, Cheng Y, Grigorieff N, Walz T, Harrison SC, Kirchhausen T. Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature. 2004 Dec 02; 432(7017):649-53. PMID: 15502813.
    Citations: 47     Fields:    Translation:AnimalsCells
  113. Heldwein EE, Macia E, Wang J, Yin HL, Kirchhausen T, Harrison SC. Crystal structure of the clathrin adaptor protein 1 core. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14108-13. PMID: 15377783.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  114. Ehrlich M, Boll W, Van Oijen A, Hariharan R, Chandran K, Nibert ML, Kirchhausen T. Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell. 2004 Sep 03; 118(5):591-605. PMID: 15339664.
    Citations: 294     Fields:    Translation:AnimalsCells
  115. Cerny J, Feng Y, Yu A, Miyake K, Borgonovo B, Klumperman J, Meldolesi J, McNeil PL, Kirchhausen T. The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep. 2004 Sep; 5(9):883-8. PMID: 15332114.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  116. Boll W, Ehrlich M, Collier RJ, Kirchhausen T. Effects of dynamin inactivation on pathways of anthrax toxin uptake. Eur J Cell Biol. 2004 Jul; 83(6):281-8. PMID: 15511085.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  117. Nieland TJ, Feng Y, Brown JX, Chuang TD, Buckett PD, Wang J, Xie XS, McGraw TE, Kirchhausen T, Wessling-Resnick M. Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic. Traffic. 2004 Jul; 5(7):478-92. PMID: 15180825.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  118. Feng Y, Jadhav AP, Rodighiero C, Fujinaga Y, Kirchhausen T, Lencer WI. Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep. 2004 Jun; 5(6):596-601. PMID: 15153932.
    Citations: 34     Fields:    Translation:AnimalsCells
  119. Massol RH, Larsen JE, Fujinaga Y, Lencer WI, Kirchhausen T. Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways. Mol Biol Cell. 2004 Aug; 15(8):3631-41. PMID: 15146065.
    Citations: 30     Fields:    Translation:AnimalsCells
  120. Nieland TJ, Chroni A, Fitzgerald ML, Maliga Z, Zannis VI, Kirchhausen T, Krieger M. Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide. J Lipid Res. 2004 Jul; 45(7):1256-65. PMID: 15102890.
    Citations: 26     Fields:    Translation:HumansCells
  121. Chandran K, Parker JS, Ehrlich M, Kirchhausen T, Nibert ML. The delta region of outer-capsid protein micro 1 undergoes conformational change and release from reovirus particles during cell entry. J Virol. 2003 Dec; 77(24):13361-75. PMID: 14645591.
    Citations: 51     Fields:    Translation:AnimalsCells
  122. Larsen JE, Massol RH, Nieland TJ, Kirchhausen T. HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity. Mol Biol Cell. 2004 Jan; 15(1):323-31. PMID: 14617802.
    Citations: 17     Fields:    Translation:HumansCells
  123. Boes M, Bertho N, Cerny J, Op den Brouw M, Kirchhausen T, Ploegh H. T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner. J Immunol. 2003 Oct 15; 171(8):4081-8. PMID: 14530329.
    Citations: 24     Fields:    Translation:AnimalsCells
  124. Wang YJ, Wang J, Sun HQ, Martinez M, Sun YX, Macia E, Kirchhausen T, Albanesi JP, Roth MG, Yin HL. Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell. 2003 Aug 08; 114(3):299-310. PMID: 12914695.
    Citations: 170     Fields:    Translation:HumansAnimalsCells
  125. Yarrow JC, Feng Y, Perlman ZE, Kirchhausen T, Mitchison TJ. Phenotypic screening of small molecule libraries by high throughput cell imaging. Comb Chem High Throughput Screen. 2003 Jun; 6(4):279-86. PMID: 12769670.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  126. Feng Y, Yu S, Lasell TK, Jadhav AP, Macia E, Chardin P, Melancon P, Roth M, Mitchison T, Kirchhausen T. Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6469-74. PMID: 12738886.
    Citations: 43     Fields:    Translation:Cells
  127. Legesse-Miller A, Massol RH, Kirchhausen T. Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission. Mol Biol Cell. 2003 May; 14(5):1953-63. PMID: 12802067.
    Citations: 59     Fields:    Translation:AnimalsCells
  128. Nieland TJ, Penman M, Dori L, Krieger M, Kirchhausen T. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15422-7. PMID: 12438696.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  129. Boes M, Cerny J, Massol R, Op den Brouw M, Kirchhausen T, Chen J, Ploegh HL. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature. 2002 Aug 29; 418(6901):983-8. PMID: 12198548.
    Citations: 125     Fields:    Translation:AnimalsCells
  130. Boll W, Rapoport I, Brunner C, Modis Y, Prehn S, Kirchhausen T. The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites. Traffic. 2002 Aug; 3(8):590-600. PMID: 12121421.
    Citations: 27     Fields:    Translation:AnimalsCells
  131. Schaefer AW, Kamei Y, Kamiguchi H, Wong EV, Rapoport I, Kirchhausen T, Beach CM, Landreth G, Lemmon SK, Lemmon V. L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1. J Cell Biol. 2002 Jun 24; 157(7):1223-32. PMID: 12082080.
    Citations: 50     Fields:    Translation:AnimalsCells
  132. Kirchhausen T. Clathrin adaptors really adapt. Cell. 2002 May 17; 109(4):413-6. PMID: 12086597.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  133. Kirchhausen T. Single-handed recognition of a sorting traffic motif by the GGA proteins. Nat Struct Biol. 2002 Apr; 9(4):241-4. PMID: 11914729.
    Citations: 7     Fields:    Translation:AnimalsCells
  134. Lederkremer GZ, Cheng Y, Petre BM, Vogan E, Springer S, Schekman R, Walz T, Kirchhausen T. Structure of the Sec23p/24p and Sec13p/31p complexes of COPII. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10704-9. PMID: 11535824.
    Citations: 34     Fields:    Translation:Cells
  135. Pelish HE, Westwood NJ, Feng Y, Kirchhausen T, Shair MD. Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product. J Am Chem Soc. 2001 Jul 11; 123(27):6740-1. PMID: 11439080.
    Citations: 22     Fields:    Translation:Cells
  136. Kirchhausen T. Three ways to make a vesicle. Nat Rev Mol Cell Biol. 2000 Dec; 1(3):187-98. PMID: 11252894.
    Citations: 153     Fields:    Translation:HumansAnimalsCells
  137. Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol. 2000 Jun 29; 10(13):758-65. PMID: 10898977.
    Citations: 74     Fields:    Translation:AnimalsCells
  138. Farr GW, Furtak K, Rowland MB, Ranson NA, Saibil HR, Kirchhausen T, Horwich AL. Multivalent binding of nonnative substrate proteins by the chaperonin GroEL. Cell. 2000 Mar 03; 100(5):561-73. PMID: 10721993.
    Citations: 51     Fields:    Translation:AnimalsCells
  139. ter Haar E, Harrison SC, Kirchhausen T. Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin. Proc Natl Acad Sci U S A. 2000 Feb 01; 97(3):1096-100. PMID: 10655490.
    Citations: 100     Fields:    Translation:AnimalsCells
  140. Kirchhausen T. Clathrin. Annu Rev Biochem. 2000; 69:699-727. PMID: 10966473.
    Citations: 165     Fields:    Translation:HumansAnimalsCells
  141. Jones AT, Spiro DJ, Kirchhausen T, Melançon P, Wessling-Resnick M. Studies on the inhibition of endosome fusion by GTPgammaS-bound ARF. J Cell Sci. 1999 Oct; 112 ( Pt 20):3477-85. PMID: 10504296.
    Citations: 1     Fields:    Translation:HumansCells
  142. Schneider H, Martin M, Agarraberes FA, Yin L, Rapoport I, Kirchhausen T, Rudd CE. Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J Immunol. 1999 Aug 15; 163(4):1868-79. PMID: 10438921.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  143. Musacchio A, Smith CJ, Roseman AM, Harrison SC, Kirchhausen T, Pearse BM. Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography. Mol Cell. 1999 Jun; 3(6):761-70. PMID: 10394364.
    Citations: 27     Fields:    Translation:Cells
  144. Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 1999 Apr 16; 97(2):221-31. PMID: 10219243.
    Citations: 400     Fields:    Translation:AnimalsCells
  145. Kirchhausen T. Cell biology. Boa constrictor or rattlesnake? Nature. 1999 Apr 08; 398(6727):470-1. PMID: 10206640.
    Citations: 5     Fields:    Translation:Cells
  146. Kirchhausen T. Adaptors for clathrin-mediated traffic. Annu Rev Cell Dev Biol. 1999; 15:705-32. PMID: 10611976.
    Citations: 132     Fields:    Translation:HumansAnimalsCells
  147. ter Haar E, Musacchio A, Harrison SC, Kirchhausen T. Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker. Cell. 1998 Nov 13; 95(4):563-73. PMID: 9827808.
    Citations: 49     Fields:    Translation:AnimalsCells
  148. Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Curr Biol. 1998 Nov 05; 8(22):1239-42. PMID: 9811611.
    Citations: 96     Fields:    Translation:HumansCells
  149. Kirchhausen T. Vesicle formation: dynamic dynamin lives up to its name. Curr Biol. 1998 Nov 05; 8(22):R792-4. PMID: 9811595.
    Citations: 3     Fields:    Translation:AnimalsCells
  150. Sanderfoot AA, Ahmed SU, Marty-Mazars D, Rapoport I, Kirchhausen T, Marty F, Raikhel NV. A putative vacuolar cargo receptor partially colocalizes with AtPEP12p on a prevacuolar compartment in Arabidopsis roots. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):9920-5. PMID: 9707576.
    Citations: 71     Fields:    Translation:AnimalsCells
  151. DeTulleo L, Kirchhausen T. The clathrin endocytic pathway in viral infection. EMBO J. 1998 Aug 17; 17(16):4585-93. PMID: 9707418.
    Citations: 95     Fields:    Translation:HumansCells
  152. Kamiguchi H, Long KE, Pendergast M, Schaefer AW, Rapoport I, Kirchhausen T, Lemmon V. The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway. J Neurosci. 1998 Jul 15; 18(14):5311-21. PMID: 9651214.
    Citations: 51     Fields:    Translation:AnimalsCells
  153. Kirchhausen T. Wiskott-Aldrich syndrome: a gene, a multifunctional protein and the beginnings of an explanation. Mol Med Today. 1998 Jul; 4(7):300-4. PMID: 9743991.
    Citations: 5     Fields:    Translation:Humans
  154. Rapoport I, Chen YC, Cupers P, Shoelson SE, Kirchhausen T. Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site. EMBO J. 1998 Apr 15; 17(8):2148-55. PMID: 9545228.
    Citations: 77     Fields:    Translation:AnimalsCells
  155. Cupers P, Jadhav AP, Kirchhausen T. Assembly of clathrin coats disrupts the association between Eps15 and AP-2 adaptors. J Biol Chem. 1998 Jan 23; 273(4):1847-50. PMID: 9442014.
    Citations: 16     Fields:    Translation:AnimalsCells
  156. Tong X, Boll W, Kirchhausen T, Howley PM. Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1. J Virol. 1998 Jan; 72(1):476-82. PMID: 9420248.
    Citations: 16     Fields:    Translation:AnimalsCells
  157. Cupers P, ter Haar E, Boll W, Kirchhausen T. Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15. J Biol Chem. 1997 Dec 26; 272(52):33430-4. PMID: 9407139.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  158. Kirchhausen T, Bonifacino JS, Riezman H. Linking cargo to vesicle formation: receptor tail interactions with coat proteins. Curr Opin Cell Biol. 1997 Aug; 9(4):488-95. PMID: 9261055.
    Citations: 108     Fields:    Translation:AnimalsCells
  159. Kirchhausen T, Pines J, Toldo L, Lafont F. Membranes and sorting. Membrane permeability. Curr Opin Cell Biol. 1997 Jul 01; 9(4):473. PMID: 9261064.
    Citations: 3     Fields:    
  160. Clairmont KB, Boll W, Ericsson M, Kirchhausen T. A role for the hinge/ear domain of the beta chains in the incorporation of AP complexes into clathrin-coated pits and coated vesicles. Cell Mol Life Sci. 1997 Jul; 53(7):611-9. PMID: 9284964.
    Citations: 5     Fields:    Translation:AnimalsCells
  161. Rapoport I, Miyazaki M, Boll W, Duckworth B, Cantley LC, Shoelson S, Kirchhausen T. Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes. EMBO J. 1997 May 01; 16(9):2240-50. PMID: 9171339.
    Citations: 61     Fields:    Translation:AnimalsCells
  162. Tebar F, Sorkina T, Sorkin A, Ericsson M, Kirchhausen T. Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits. J Biol Chem. 1996 Nov 15; 271(46):28727-30. PMID: 8910509.
    Citations: 69     Fields:    Translation:AnimalsCells
  163. Boll W, Ohno H, Songyang Z, Rapoport I, Cantley LC, Bonifacino JS, Kirchhausen T. Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes. EMBO J. 1996 Nov 01; 15(21):5789-95. PMID: 8918456.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  164. Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ. Identification of Itk/Tsk Src homology 3 domain ligands. J Biol Chem. 1996 Oct 11; 271(41):25646-56. PMID: 8810341.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  165. Bonifacino JS, Marks MS, Ohno H, Kirchhausen T. Mechanisms of signal-mediated protein sorting in the endocytic and secretory pathways. Proc Assoc Am Physicians. 1996 Jul; 108(4):285-95. PMID: 8863342.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  166. Kirchhausen T, Rosen FS. Disease mechanism: unravelling Wiskott-Aldrich syndrome. Curr Biol. 1996 Jun 01; 6(6):676-8. PMID: 8793292.
    Citations: 9     Fields:    Translation:Humans
  167. Kolluri R, Tolias KF, Carpenter CL, Rosen FS, Kirchhausen T. Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5615-8. PMID: 8643625.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  168. Spiro DJ, Boll W, Kirchhausen T, Wessling-Resnick M. Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro. Mol Biol Cell. 1996 Mar; 7(3):355-67. PMID: 8868465.
    Citations: 58     Fields:    Translation:HumansCells
  169. Shih W, Gallusser A, Kirchhausen T. A clathrin-binding site in the hinge of the beta 2 chain of mammalian AP-2 complexes. J Biol Chem. 1995 Dec 29; 270(52):31083-90. PMID: 8537368.
    Citations: 68     Fields:    Translation:AnimalsCells
  170. Boll W, Gallusser A, Kirchhausen T. Role of the regulatory domain of the EGF-receptor cytoplasmic tail in selective binding of the clathrin-associated complex AP-2. Curr Biol. 1995 Oct 01; 5(10):1168-78. PMID: 8548289.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  171. Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS. Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science. 1995 Sep 29; 269(5232):1872-5. PMID: 7569928.
    Citations: 317     Fields:    Translation:AnimalsCells
  172. Rad MR, Phan HL, Kirchrath L, Tan PK, Kirchhausen T, Hollenberg CP, Payne GS. Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions. J Cell Sci. 1995 Apr; 108 ( Pt 4):1605-15. PMID: 7615679.
    Citations: 29     Fields:    Translation:AnimalsCells
  173. Speelman BA, Allen K, Grounds TL, Neutra MR, Kirchhausen T, Wilson JM. Molecular characterization of an apical early endosomal glycoprotein from developing rat intestinal epithelial cells. J Biol Chem. 1995 Jan 27; 270(4):1583-8. PMID: 7829488.
    Citations: 5     Fields:    Translation:AnimalsCells
  174. Sorkin A, McKinsey T, Shih W, Kirchhausen T, Carpenter G. Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2. J Biol Chem. 1995 Jan 13; 270(2):619-25. PMID: 7822287.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  175. Stepp JD, Pellicena-Palle A, Hamilton S, Kirchhausen T, Lemmon SK. A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein. Mol Biol Cell. 1995 Jan; 6(1):41-58. PMID: 7749194.
    Citations: 45     Fields:    Translation:AnimalsCells
  176. Søgaard M, Tani K, Ye RR, Geromanos S, Tempst P, Kirchhausen T, Rothman JE, Söllner T. A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell. 1994 Sep 23; 78(6):937-48. PMID: 7923363.
    Citations: 160     Fields: