Harvard Catalyst Profiles

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Tomas Leopold Kirchhausen, Ph.D.

Other Positions

Secramine: Specificity and Inhibition of Cell Transformation
Summer, 06/27/05 - 08/19/05

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI163019 (WHELAN, SEAN PJ) Jul 8, 2021 - Jun 30, 2026
    Mechanism and Inhibition of SARS-CoV-2 Entry
    Role: Co-Principal Investigator
  2. R35GM130386 (KIRCHHAUSEN, TOMAS) Mar 1, 2019 - Feb 29, 2024
    Role: Principal Investigator
  3. U19AI109740 (WHELAN, SEAN PJ) Mar 1, 2014 - Feb 28, 2019
    Small molecule inhibitors of enveloped virus entry
    Role: Co-Principal Investigator
  4. R01GM075252 (KIRCHHAUSEN, TOMAS) Sep 10, 2005 - Mar 31, 2019
    Dynamics of Clathrin Coat Formation in Cells
    Role: Principal Investigator
  5. U54AI057159 (KASPER, DENNIS L.) Sep 4, 2003 - Feb 28, 2015
    New England Regional Center of Excellence in Biodefense and Emerging Infectious D
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bakkers MJG, Moon-Walker A, Herlo R, Brusic V, Stubbs SH, Hastie KM, Saphire EO, Kirchhausen TL, Whelan SPJ. CD164 is a host factor for lymphocytic choriomeningitis virus entry. Proc Natl Acad Sci U S A. 2022 03 08; 119(10):e2119676119. PMID: 35235462.
    Citations:    Fields:    
  2. Kreutzberger AJB, Sanyal A, Ojha R, Pyle JD, Vapalahti O, Balistreri G, Kirchhausen T. Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease. J Virol. 2021 10 13; 95(21):e0097521. PMID: 34406858.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  3. Kreutzberger AJB, Sanyal A, Ojha R, Pyle JD, Vapalahti O, Balistreri G, Kirchhausen T. Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease. bioRxiv. 2021 Aug 12. PMID: 34100014.
  4. Chou YY, Upadhyayula S, Houser J, He K, Skillern W, Scanavachi G, Dang S, Sanyal A, Ohashi KG, Di Caprio G, Kreutzberger AJB, Vadakkan TJ, Kirchhausen T. Inherited nuclear pore substructures template post-mitotic pore assembly. Dev Cell. 2021 06 21; 56(12):1786-1803.e9. PMID: 34129835.
    Citations: 1     Fields:    Translation:HumansCells
  5. Emperador-Melero J, Wong MY, Wang SSH, de Nola G, Nyitrai H, Kirchhausen T, Kaeser PS. PKC-phosphorylation of Liprin-a3 triggers phase separation and controls presynaptic active zone structure. Nat Commun. 2021 05 24; 12(1):3057. PMID: 34031393.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  6. Chen YC, Dinavahi SS, Feng Q, Gowda R, Ramisetti S, Xia X, LaPenna KB, Chirasani VR, Cho SH, Hafenstein SL, Battu MB, Berg A, Sharma AK, Kirchhausen T, Dokholyan NV, Amin S, He P, Robertson GP. Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis. Cancer Lett. 2021 05 28; 506:107-119. PMID: 33600895.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Zang R, Case JB, Yutuc E, Ma X, Shen S, Gomez Castro MF, Liu Z, Zeng Q, Zhao H, Son J, Rothlauf PW, Kreutzberger AJB, Hou G, Zhang H, Bose S, Wang X, Vahey MD, Mani K, Griffiths WJ, Kirchhausen T, Fremont DH, Guo H, Diwan A, Wang Y, Diamond MS, Whelan SPJ, Ding S. Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Proc Natl Acad Sci U S A. 2020 12 15; 117(50):32105-32113. PMID: 33239446.
    Citations: 53     Fields:    Translation:HumansCells
  8. Salman MM, Marsh G, Kusters I, Delincé M, Di Caprio G, Upadhyayula S, de Nola G, Hunt R, Ohashi KG, Gray T, Shimizu F, Sano Y, Kanda T, Obermeier B, Kirchhausen T. Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging. Front Bioeng Biotechnol. 2020; 8:573775. PMID: 33117784.
    Citations: 42     
  9. Shipley FB, Dani N, Xu H, Deister C, Cui J, Head JP, Sadegh C, Fame RM, Shannon ML, Flores VI, Kishkovich T, Jang E, Klein EM, Goldey GJ, He K, Zhang Y, Holtzman MJ, Kirchhausen T, Wyart C, Moore CI, Andermann ML, Lehtinen MK. Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface. Neuron. 2020 11 25; 108(4):623-639.e10. PMID: 32961128.
    Citations: 12     Fields:    Translation:Animals
  10. Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020 09 18; 369(6510). PMID: 32943500.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  11. Kang YL, Chou YY, Rothlauf PW, Liu Z, Soh TK, Cureton D, Case JB, Chen RE, Diamond MS, Whelan SPJ, Kirchhausen T. Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2. Proc Natl Acad Sci U S A. 2020 08 25; 117(34):20803-20813. PMID: 32764148.
    Citations: 55     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  12. Bloyet LM, Morin B, Brusic V, Gardner E, Ross RA, Vadakkan T, Kirchhausen T, Whelan SPJ. Oligomerization of the Vesicular Stomatitis Virus Phosphoprotein Is Dispensable for mRNA Synthesis but Facilitates RNA Replication. J Virol. 2020 06 16; 94(13). PMID: 32321813.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Kang YL, Chou YY, Rothlauf PW, Liu Z, Soh TK, Cureton D, Case JB, Chen RE, Diamond MS, Whelan SPJ, Kirchhausen T. Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2. bioRxiv. 2020 Jun 15. PMID: 32511398.
  14. He K, Song E, Upadhyayula S, Dang S, Gaudin R, Skillern W, Bu K, Capraro BR, Rapoport I, Kusters I, Ma M, Kirchhausen T. Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic. J Cell Biol. 2020 03 02; 219(3). PMID: 31962345.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  15. Hoffman DP, Shtengel G, Xu CS, Campbell KR, Freeman M, Wang L, Milkie DE, Pasolli HA, Iyer N, Bogovic JA, Stabley DR, Shirinifard A, Pang S, Peale D, Schaefer K, Pomp W, Chang CL, Lippincott-Schwartz J, Kirchhausen T, Solecki DJ, Betzig E, Hess HF. Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells. Science. 2020 01 17; 367(6475). PMID: 31949053.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  16. Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S. Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling. Cell Rep. 2019 06 04; 27(10):3049-3061.e6. PMID: 31167147.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  17. Calzoni E, Platt CD, Keles S, Kuehn HS, Beaussant-Cohen S, Zhang Y, Pazmandi J, Lanzi G, Pala F, Tahiat A, Artac H, Heredia RJ, Dmytrus J, Reisli I, Uygun V, Uygun D, Bingol A, Basaran E, Djenouhat K, Benhalla N, Bendahmane C, Emiroglu M, Kirchhausen T, Pasham M, Jones J, Wallace JG, Zheng L, Boisson B, Porta F, Rosenzweig SD, Su H, Giliani S, Lenardo M, Geha RS, Boztug K, Chou J, Notarangelo LD. F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects. J Allergy Clin Immunol. 2019 06; 143(6):2317-2321.e12. PMID: 30822429.
    Citations: 6     Fields:    Translation:Humans
  18. Gao R, Asano SM, Upadhyayula S, Pisarev I, Milkie DE, Liu TL, Singh V, Graves A, Huynh GH, Zhao Y, Bogovic J, Colonell J, Ott CM, Zugates C, Tappan S, Rodriguez A, Mosaliganti KR, Sheu SH, Pasolli HA, Pang S, Xu CS, Megason SG, Hess H, Lippincott-Schwartz J, Hantman A, Rubin GM, Kirchhausen T, Saalfeld S, Aso Y, Boyden ES, Betzig E. Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution. Science. 2019 01 18; 363(6424). PMID: 30655415.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  19. Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA. The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Rep. 2018 07 24; 24(4):973-986.e8. PMID: 30044992.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  20. Swinburne IA, Mosaliganti KR, Upadhyayula S, Liu TL, Hildebrand DGC, Tsai TY, Chen A, Al-Obeidi E, Fass AK, Malhotra S, Engert F, Lichtman JW, Kirchhausen T, Betzig E, Megason SG. Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure. Elife. 2018 06 19; 7. PMID: 29916365.
    Citations: 6     Fields:    Translation:Animals
  21. Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E. Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science. 2018 04 20; 360(6386). PMID: 29674564.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  22. Böcking T, Upadhyayula S, Rapoport I, Capraro BR, Kirchhausen T. Reconstitution of Clathrin Coat Disassembly for Fluorescence Microscopy and Single-Molecule Analysis. Methods Mol Biol. 2018; 1847:121-146. PMID: 30129014.
    Citations: 2     Fields:    Translation:Cells
  23. He K, Marsland R, Upadhyayula S, Song E, Dang S, Capraro BR, Wang W, Skillern W, Gaudin R, Ma M, Kirchhausen T. Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic. Nature. 2017 12 21; 552(7685):410-414. PMID: 29236694.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  24. Raaben M, Jae LT, Herbert AS, Kuehne AI, Stubbs SH, Chou YY, Blomen VA, Kirchhausen T, Dye JM, Brummelkamp TR, Whelan SP. NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry. Cell Host Microbe. 2017 Nov 08; 22(5):688-696.e5. PMID: 29120745.
    Citations: 47     Fields:    Translation:HumansCells
  25. Adell MAY, Migliano SM, Upadhyayula S, Bykov YS, Sprenger S, Pakdel M, Vogel GF, Jih G, Skillern W, Behrouzi R, Babst M, Schmidt O, Hess MW, Briggs JA, Kirchhausen T, Teis D. Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding. Elife. 2017 10 11; 6. PMID: 29019322.
    Citations: 49     Fields:    Translation:AnimalsCells
  26. Paulsen BS, Mandal PK, Frock RL, Boyraz B, Yadav R, Upadhyayula S, Gutierrez-Martinez P, Ebina W, Fasth A, Kirchhausen T, Talkowski ME, Agarwal S, Alt FW, Rossi DJ. Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing. Nat Biomed Eng. 2017 11; 1(11):878-888. PMID: 31015609.
    Citations: 29     Fields:    Translation:HumansCells
  27. Schuler MH, Lewandowska A, Caprio GD, Skillern W, Upadhyayula S, Kirchhausen T, Shaw JM, Cunniff B. Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration. Mol Biol Cell. 2017 Aug 01; 28(16):2159-2169. PMID: 28615318.
    Citations: 52     Fields:    Translation:AnimalsCells
  28. Chou YY, Krupp A, Kaynor C, Gaudin R, Ma M, Cahir-McFarland E, Kirchhausen T. Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9. Sci Rep. 2016 11 14; 6:36921. PMID: 27841295.
    Citations: 9     Fields:    Translation:HumansCells
  29. Hu Y, Kim JH, He K, Wan Q, Kim J, Flach M, Kirchhausen T, Vortkamp A, Winau F. Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion. J Exp Med. 2016 11 14; 213(12):2759-2772. PMID: 27810927.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  30. Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S. Membrane fission by dynamin: what we know and what we need to know. EMBO J. 2016 11 02; 35(21):2270-2284. PMID: 27670760.
    Citations: 162     Fields:    Translation:HumansAnimalsCells
  31. Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV. Seipin is required for converting nascent to mature lipid droplets. Elife. 2016 Aug 26; 5. PMID: 27564575.
    Citations: 122     Fields:    
  32. Aguet F, Upadhyayula S, Gaudin R, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, Megason S, Betzig E, Kirchhausen T. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Mol Biol Cell. 2016 11 07; 27(22):3418-3435. PMID: 27535432.
    Citations: 37     Fields:    Translation:AnimalsCells
  33. Chou YY, Cuevas C, Carocci M, Stubbs SH, Ma M, Cureton DK, Chao L, Evesson F, He K, Yang PL, Whelan SP, Ross SR, Kirchhausen T, Gaudin R. Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. J Virol. 2016 May; 90(9):4494-4510. PMID: 26912630.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  34. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. PMID: 26947396.
    Citations: 66     Fields:    
  35. Reeves PM, Kang YL, Kirchhausen T. Endocytosis of Ligand-Activated Sphingosine 1-Phosphate Receptor 1 Mediated by the Clathrin-Pathway. Traffic. 2016 Jan; 17(1):40-52. PMID: 26481905.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  36. Gaudin R, Kirchhausen T. Superinfection exclusion is absent during acute Junin virus infection of Vero and A549 cells. Sci Rep. 2015 Nov 09; 5:15990. PMID: 26549784.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  37. Li D, Shao L, Chen BC, Zhang X, Zhang M, Moses B, Milkie DE, Beach JR, Hammer JA, Pasham M, Kirchhausen T, Baird MA, Davidson MW, Xu P, Betzig E. ADVANCED IMAGING. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics. Science. 2015 Aug 28; 349(6251):aab3500. PMID: 26315442.
    Citations: 197     Fields:    Translation:AnimalsCells
  38. Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nat Biotechnol. 2015 Aug; 33(8):870-6. PMID: 26192320.
    Citations: 136     Fields:    Translation:HumansCells
  39. Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes. Cell. 2015 May 21; 161(5):1229. PMID: 28910642.
    Citations: 8     Fields:    
  40. Kural C, Akatay AA, Gaudin R, Chen BC, Legant WR, Betzig E, Kirchhausen T. Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells. Mol Biol Cell. 2015 Jun 01; 26(11):2044-53. PMID: 25851602.
    Citations: 17     Fields:    Translation:HumansCells
  41. Ishikawa Y, Maeda M, Pasham M, Aguet F, Tacheva-Grigorova SK, Masuda T, Yi H, Lee SU, Xu J, Teruya-Feldstein J, Ericsson M, Mullally A, Heuser J, Kirchhausen T, Maeda T. Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology. Haematologica. 2015 Apr; 100(4):439-51. PMID: 25552701.
    Citations: 16     Fields:    Translation:AnimalsCells
  42. Hagemann AI, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S. In vivo analysis of formation and endocytosis of the Wnt/ß-Catenin signaling complex in zebrafish embryos. J Cell Sci. 2014 Dec 15; 127(24):5331. PMID: 25512326.
  43. Cocucci E, Gaudin R, Kirchhausen T. Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit. Mol Biol Cell. 2014 Nov 05; 25(22):3595-609. PMID: 25232009.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  44. Abdelhakim AH, Salgado EN, Fu X, Pasham M, Nicastro D, Kirchhausen T, Harrison SC. Structural correlates of rotavirus cell entry. PLoS Pathog. 2014 Sep; 10(9):e1004355. PMID: 25211455.
    Citations: 13     Fields:    Translation:AnimalsCells
  45. Hagemann AI, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S. In vivo analysis of formation and endocytosis of the Wnt/ß-catenin signaling complex in zebrafish embryos. J Cell Sci. 2014 Sep 15; 127(Pt 18):3970-82. PMID: 25074807.
    Citations: 37     Fields:    Translation:AnimalsCells
  46. Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes. Cell. 2014 Jun 05; 157(6):1309-1323. PMID: 24906149.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  47. Böcking T, Aguet F, Rapoport I, Banzhaf M, Yu A, Zeeh JC, Kirchhausen T. Key interactions for clathrin coat stability. Structure. 2014 Jun 10; 22(6):819-29. PMID: 24815030.
    Citations: 11     Fields:    Translation:AnimalsCells
  48. Kirchhausen T, Owen D, Harrison SC. Molecular structure, function, and dynamics of clathrin-mediated membrane traffic. Cold Spring Harb Perspect Biol. 2014 May 01; 6(5):a016725. PMID: 24789820.
    Citations: 189     Fields:    Translation:HumansAnimalsCells
  49. Carmo-Fonseca M, Kirchhausen T. The timing of pre-mRNA splicing visualized in real-time. Nucleus. 2014 Jan-Feb; 5(1):11-4. PMID: 24637398.
    Citations: 8     Fields:    Translation:Cells
  50. Martin RM, Rino J, Carvalho C, Kirchhausen T, Carmo-Fonseca M. Live-cell visualization of pre-mRNA splicing with single-molecule sensitivity. Cell Rep. 2013 Sep 26; 4(6):1144-55. PMID: 24035393.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  51. Piccinotti S, Kirchhausen T, Whelan SP. Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin. J Virol. 2013 Nov; 87(21):11637-47. PMID: 23966407.
    Citations: 42     Fields:    Translation:AnimalsCells
  52. Tacheva-Grigorova SK, Santos AJ, Boucrot E, Kirchhausen T. Clathrin-mediated endocytosis persists during unperturbed mitosis. Cell Rep. 2013 Aug 29; 4(4):659-68. PMID: 23954786.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  53. Heesters BA, Chatterjee P, Kim YA, Gonzalez SF, Kuligowski MP, Kirchhausen T, Carroll MC. Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation. Immunity. 2013 Jun 27; 38(6):1164-75. PMID: 23770227.
    Citations: 104     Fields:    Translation:AnimalsCells
  54. Martinelli R, Kamei M, Sage PT, Massol R, Varghese L, Sciuto T, Toporsian M, Dvorak AM, Kirchhausen T, Springer TA, Carman CV. Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds. J Cell Biol. 2013 Apr 29; 201(3):449-65. PMID: 23629967.
    Citations: 44     Fields:    Translation:HumansCells
  55. Boulant S, Stanifer M, Kural C, Cureton DK, Massol R, Nibert ML, Kirchhausen T. Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2013 Apr; 24(8):1196-207. PMID: 23427267.
    Citations: 24     Fields:    Translation:AnimalsCells
  56. Lu L, Hannoush RN, Goess BC, Varadarajan S, Shair MD, Kirchhausen T. The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export. Mol Biol Cell. 2013 Apr; 24(7):1020-9. PMID: 23389632.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  57. Kural C, Tacheva-Grigorova SK, Boulant S, Cocucci E, Baust T, Duarte D, Kirchhausen T. Dynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers. Cell Rep. 2012 Nov 29; 2(5):1111-9. PMID: 23103167.
    Citations: 39     Fields:    Translation:AnimalsCells
  58. Kirchhausen T. Bending membranes. Nat Cell Biol. 2012 Sep; 14(9):906-8. PMID: 22945258.
    Citations: 38     Fields:    Translation:Cells
  59. Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M. Small molecule-mediated TGF-ß type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 03; 11(2):242-52. PMID: 22862949.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  60. Cocucci E, Aguet F, Boulant S, Kirchhausen T. The first five seconds in the life of a clathrin-coated pit. Cell. 2012 Aug 03; 150(3):495-507. PMID: 22863004.
    Citations: 152     Fields:    Translation:AnimalsCells
  61. Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S. Regulation of ligand-independent Notch signal through intracellular trafficking. Commun Integr Biol. 2012 Jul 01; 5(4):374-6. PMID: 23060962.
    Citations: 13     
  62. Cureton DK, Harbison CE, Cocucci E, Parrish CR, Kirchhausen T. Limited transferrin receptor clustering allows rapid diffusion of canine parvovirus into clathrin endocytic structures. J Virol. 2012 May; 86(9):5330-40. PMID: 22357278.
    Citations: 27     Fields:    Translation:AnimalsCells
  63. Strang BL, Boulant S, Kirchhausen T, Coen DM. Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments. mBio. 2012; 3(1). PMID: 22318319.
    Citations: 24     Fields:    Translation:HumansCells
  64. Kural C, Kirchhausen T. Live-cell imaging of clathrin coats. Methods Enzymol. 2012; 505:59-80. PMID: 22289448.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  65. Lu L, Kirchhausen T. Visualizing the high curvature regions of post-mitotic nascent nuclear envelope membrane. Commun Integr Biol. 2012 Jan 01; 5(1):16-8. PMID: 22482003.
    Citations: 5     
  66. Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S. Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol. 2011 Dec 12; 195(6):1005-15. PMID: 22162134.
    Citations: 50     Fields:    Translation:AnimalsCells
  67. Strang BL, Boulant S, Chang L, Knipe DM, Kirchhausen T, Coen DM. Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis. J Virol. 2012 Feb; 86(4):2089-95. PMID: 22156516.
    Citations: 29     Fields:    Translation:HumansCells
  68. Boulant S, Kural C, Zeeh JC, Ubelmann F, Kirchhausen T. Actin dynamics counteract membrane tension during clathrin-mediated endocytosis. Nat Cell Biol. 2011 Aug 14; 13(9):1124-31. PMID: 21841790.
    Citations: 236     Fields:    Translation:AnimalsCells
  69. Lu L, Ladinsky MS, Kirchhausen T. Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly. J Cell Biol. 2011 Aug 08; 194(3):425-40. PMID: 21825076.
    Citations: 55     Fields:    Translation:HumansCells
  70. Ivanovic T, Boulant S, Ehrlich M, Demidenko AA, Arnold MM, Kirchhausen T, Nibert ML. Recruitment of cellular clathrin to viral factories and disruption of clathrin-dependent trafficking. Traffic. 2011 Sep; 12(9):1179-95. PMID: 21736684.
    Citations: 15     Fields:    Translation:AnimalsCells
  71. Thiery J, Keefe D, Boulant S, Boucrot E, Walch M, Martinvalet D, Goping IS, Bleackley RC, Kirchhausen T, Lieberman J. Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol. 2011 Jun 19; 12(8):770-7. PMID: 21685908.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  72. Boucrot E, Howes MT, Kirchhausen T, Parton RG. Redistribution of caveolae during mitosis. J Cell Sci. 2011 Jun 15; 124(Pt 12):1965-72. PMID: 21625007.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  73. Bai M, Gad H, Turacchio G, Cocucci E, Yang JS, Li J, Beznoussenko GV, Nie Z, Luo R, Fu L, Collawn JF, Kirchhausen T, Luini A, Hsu VW. ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol. 2011 May; 13(5):559-67. PMID: 21499258.
    Citations: 25     Fields:    Translation:Humans
  74. Böcking T, Aguet F, Harrison SC, Kirchhausen T. Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating. Nat Struct Mol Biol. 2011 Mar; 18(3):295-301. PMID: 21278753.
    Citations: 58     Fields:    Translation:AnimalsCells
  75. Yu A, Xing Y, Harrison SC, Kirchhausen T. Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure. 2010 Oct 13; 18(10):1311-20. PMID: 20947020.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  76. Cureton DK, Massol RH, Whelan SP, Kirchhausen T. The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis. PLoS Pathog. 2010 Sep 30; 6(9):e1001127. PMID: 20941355.
    Citations: 82     Fields:    Translation:AnimalsCells
  77. Guan R, Dai H, Han D, Harrison SC, Kirchhausen T. Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding. Structure. 2010 Sep 08; 18(9):1191-8. PMID: 20826345.
    Citations: 27     Fields:    Translation:AnimalsCells
  78. Harrison SC, Kirchhausen T. Structural biology: Conservation in vesicle coats. Nature. 2010 Aug 26; 466(7310):1048-9. PMID: 20739998.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  79. Utskarpen A, Massol R, van Deurs B, Lauvrak SU, Kirchhausen T, Sandvig K. Shiga toxin increases formation of clathrin-coated pits through Syk kinase. PLoS One. 2010 Jul 27; 5(7):e10944. PMID: 20668539.
    Citations: 22     Fields:    Translation:HumansCells
  80. Boucrot E, Saffarian S, Zhang R, Kirchhausen T. Roles of AP-2 in clathrin-mediated endocytosis. PLoS One. 2010 May 12; 5(5):e10597. PMID: 20485680.
    Citations: 59     Fields:    Translation:HumansCells
  81. Anitei M, Stange C, Parshina I, Baust T, Schenck A, Raposo G, Kirchhausen T, Hoflack B. Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN. Nat Cell Biol. 2010 Apr; 12(4):330-40. PMID: 20228810.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  82. Smits P, Bolton AD, Funari V, Hong M, Boyden ED, Lu L, Manning DK, Dwyer ND, Moran JL, Prysak M, Merriman B, Nelson SF, Bonafé L, Superti-Furga A, Ikegawa S, Krakow D, Cohn DH, Kirchhausen T, Warman ML, Beier DR. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. N Engl J Med. 2010 Jan 21; 362(3):206-16. PMID: 20089971.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  83. Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, Kirchhausen T, Lieberman J. Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood. 2010 Feb 25; 115(8):1582-93. PMID: 20038786.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  84. Xing Y, Böcking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SC. Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly. EMBO J. 2010 Feb 03; 29(3):655-65. PMID: 20033059.
    Citations: 58     Fields:    Translation:AnimalsCells
  85. Kirchhausen T. Imaging endocytic clathrin structures in living cells. Trends Cell Biol. 2009 Nov; 19(11):596-605. PMID: 19836955.
    Citations: 85     Fields:    Translation:HumansAnimals
  86. Saffarian S, Cocucci E, Kirchhausen T. Distinct dynamics of endocytic clathrin-coated pits and coated plaques. PLoS Biol. 2009 Sep; 7(9):e1000191. PMID: 19809571.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  87. Lu L, Ladinsky MS, Kirchhausen T. Cisternal organization of the endoplasmic reticulum during mitosis. Mol Biol Cell. 2009 Aug; 20(15):3471-80. PMID: 19494040.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  88. Cureton DK, Massol RH, Saffarian S, Kirchhausen TL, Whelan SP. Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization. PLoS Pathog. 2009 Apr; 5(4):e1000394. PMID: 19390604.
    Citations: 174     Fields:    Translation:Cells
  89. Shulman Z, Shinder V, Klein E, Grabovsky V, Yeger O, Geron E, Montresor A, Bolomini-Vittori M, Feigelson SW, Kirchhausen T, Laudanna C, Shakhar G, Alon R. Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity. 2009 Mar 20; 30(3):384-96. PMID: 19268609.
    Citations: 108     Fields:    Translation:HumansCells
  90. Ambrogio C, Voena C, Manazza AD, Martinengo C, Costa C, Kirchhausen T, Hirsch E, Inghirami G, Chiarle R. The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation. Cancer Res. 2008 Nov 01; 68(21):8899-907. PMID: 18974134.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  91. Boucrot E, Kirchhausen T. Mammalian cells change volume during mitosis. PLoS One. 2008 Jan 23; 3(1):e1477. PMID: 18213385.
    Citations: 39     Fields:    Translation:AnimalsCells
  92. Kirchhausen T, Macia E, Pelish HE. Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods Enzymol. 2008; 438:77-93. PMID: 18413242.
    Citations: 181     Fields:    Translation:HumansAnimalsCells
  93. Nieland TJ, Shaw JT, Jaipuri FA, Duffner JL, Koehler AN, Banakos S, Zannis VI, Kirchhausen T, Krieger M. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 08; 47(1):460-72. PMID: 18067275.
    Citations: 18     Fields:    Translation:HumansCells
  94. Veiga E, Guttman JA, Bonazzi M, Boucrot E, Toledo-Arana A, Lin AE, Enninga J, Pizarro-Cerdá J, Finlay BB, Kirchhausen T, Cossart P. Invasive and adherent bacterial pathogens co-Opt host clathrin for infection. Cell Host Microbe. 2007 Nov 15; 2(5):340-51. PMID: 18005755.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  95. Saffarian S, Kirchhausen T. Differential evanescence nanometry: live-cell fluorescence measurements with 10-nm axial resolution on the plasma membrane. Biophys J. 2008 Mar 15; 94(6):2333-42. PMID: 17993495.
    Citations: 57     Fields:    Translation:AnimalsCells
  96. Rapoport I, Boll W, Yu A, Böcking T, Kirchhausen T. A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction. Mol Biol Cell. 2008 Jan; 19(1):405-13. PMID: 17978091.
    Citations: 31     Fields:    Translation:AnimalsCells
  97. Jiang S, Zhou X, Kirchhausen T, Wong ST. Tracking molecular particles in live cells using fuzzy rule-based system. Cytometry A. 2007 Aug; 71(8):576-84. PMID: 17542029.
    Citations: 4     Fields:    Translation:Animals
  98. Jiang S, Zhou X, Kirchhausen T, Wong ST. Detection of molecular particles in live cells via machine learning. Cytometry A. 2007 Aug; 71(8):563-75. PMID: 17431884.
    Citations: 9     Fields:    Translation:AnimalsCells
  99. Li J, Peters PJ, Bai M, Dai J, Bos E, Kirchhausen T, Kandror KV, Hsu VW. An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol. 2007 Jul 30; 178(3):453-64. PMID: 17664335.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  100. Kirchhausen T. Making COPII coats. Cell. 2007 Jun 29; 129(7):1251-2. PMID: 17604713.
    Citations: 4     Fields:    Translation:AnimalsCells
  101. Wang J, Sun HQ, Macia E, Kirchhausen T, Watson H, Bonifacino JS, Yin HL. PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal. Mol Biol Cell. 2007 Jul; 18(7):2646-55. PMID: 17494868.
    Citations: 76     Fields:    Translation:HumansCells
  102. Boucrot E, Kirchhausen T. Endosomal recycling controls plasma membrane area during mitosis. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):7939-44. PMID: 17483462.
    Citations: 143     Fields:    Translation:HumansCells
  103. Ma YM, Boucrot E, Villén J, Affar EB, Gygi SP, Göttlinger HG, Kirchhausen T. Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. J Biol Chem. 2007 Mar 30; 282(13):9805-9812. PMID: 17261583.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  104. Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X, Kirchhausen T. Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling. Dev Cell. 2007 Jan; 12(1):129-41. PMID: 17199046.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  105. Xu B, Pelish H, Kirchhausen T, Hammond GB. Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading. Org Biomol Chem. 2006 Nov 21; 4(22):4149-57. PMID: 17312971.
    Citations: 13     Fields:    Translation:AnimalsCells
  106. Newton AJ, Kirchhausen T, Murthy VN. Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17955-60. PMID: 17093049.
    Citations: 118     Fields:    Translation:AnimalsCells
  107. Falcone S, Cocucci E, Podini P, Kirchhausen T, Clementi E, Meldolesi J. Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events. J Cell Sci. 2006 Nov 15; 119(Pt 22):4758-69. PMID: 17077125.
    Citations: 96     Fields:    Translation:HumansCells
  108. Cheng Y, Boll W, Kirchhausen T, Harrison SC, Walz T. Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol. 2007 Jan 19; 365(3):892-9. PMID: 17095010.
    Citations: 56     Fields:    Translation:AnimalsCells
  109. Boucrot E, Saffarian S, Massol R, Kirchhausen T, Ehrlich M. Role of lipids and actin in the formation of clathrin-coated pits. Exp Cell Res. 2006 Dec 10; 312(20):4036-48. PMID: 17097636.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  110. Fotin A, Kirchhausen T, Grigorieff N, Harrison SC, Walz T, Cheng Y. Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. J Struct Biol. 2006 Dec; 156(3):453-60. PMID: 16908193.
    Citations: 17     Fields:    Translation:Cells
  111. Massol RH, Boll W, Griffin AM, Kirchhausen T. A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10265-10270. PMID: 16798879.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  112. Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006 Jun; 10(6):839-50. PMID: 16740485.
    Citations: 947     Fields:    Translation:HumansCells
  113. Goess BC, Hannoush RN, Chan LK, Kirchhausen T, Shair MD. Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors. J Am Chem Soc. 2006 Apr 26; 128(16):5391-403. PMID: 16620111.
    Citations: 15     Fields:    Translation:Cells
  114. Pelish HE, Ciesla W, Tanaka N, Reddy K, Shair MD, Kirchhausen T, Lencer WI. The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells. Biochem Pharmacol. 2006 Jun 14; 71(12):1720-6. PMID: 16677615.
    Citations: 6     Fields:    Translation:HumansCells
  115. Pelish HE, Peterson JR, Salvarezza SB, Rodriguez-Boulan E, Chen JL, Stamnes M, Macia E, Feng Y, Shair MD, Kirchhausen T. Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol. 2006 Jan; 2(1):39-46. PMID: 16408091.
    Citations: 75     Fields:    Translation:AnimalsCells
  116. Keefe D, Shi L, Feske S, Massol R, Navarro F, Kirchhausen T, Lieberman J. Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity. 2005 Sep; 23(3):249-62. PMID: 16169498.
    Citations: 126     Fields:    Translation:HumansCells
  117. McNeil PL, Kirchhausen T. An emergency response team for membrane repair. Nat Rev Mol Cell Biol. 2005 Jun; 6(6):499-505. PMID: 15928713.
    Citations: 181     Fields:    Translation:AnimalsCells
  118. Paleotti O, Macia E, Luton F, Klein S, Partisani M, Chardin P, Kirchhausen T, Franco M. The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes. J Biol Chem. 2005 Jun 03; 280(22):21661-6. PMID: 15802264.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  119. Massol RH, Larsen JE, Kirchhausen T. Possible role of deep tubular invaginations of the plasma membrane in MHC-I trafficking. Exp Cell Res. 2005 May 15; 306(1):142-9. PMID: 15878340.
    Citations: 8     Fields:    Translation:HumansCells
  120. Nieland TJ, Ehrlich M, Krieger M, Kirchhausen T. Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI. Biochim Biophys Acta. 2005 May 01; 1734(1):44-51. PMID: 15866482.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  121. Kirchhausen T, Boll W, van Oijen A, Ehrlich M. Single-molecule live-cell imaging of clathrin-based endocytosis. Biochem Soc Symp. 2005; (72):71-6. PMID: 15649131.
    Citations: 6     Fields:    Translation:AnimalsCells
  122. Benedito AB, Lehtinen M, Massol R, Lopes UG, Kirchhausen T, Rao A, Bonni A. The transcription factor NFAT3 mediates neuronal survival. J Biol Chem. 2005 Jan 28; 280(4):2818-25. PMID: 15537643.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  123. Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 02; 432(7017):573-9. PMID: 15502812.
    Citations: 201     Fields:    Translation:AnimalsCells
  124. Fotin A, Cheng Y, Grigorieff N, Walz T, Harrison SC, Kirchhausen T. Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature. 2004 Dec 02; 432(7017):649-53. PMID: 15502813.
    Citations: 68     Fields:    Translation:AnimalsCells
  125. Heldwein EE, Macia E, Wang J, Yin HL, Kirchhausen T, Harrison SC. Crystal structure of the clathrin adaptor protein 1 core. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14108-13. PMID: 15377783.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  126. Ehrlich M, Boll W, Van Oijen A, Hariharan R, Chandran K, Nibert ML, Kirchhausen T. Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell. 2004 Sep 03; 118(5):591-605. PMID: 15339664.
    Citations: 378     Fields:    Translation:AnimalsCells
  127. Cerny J, Feng Y, Yu A, Miyake K, Borgonovo B, Klumperman J, Meldolesi J, McNeil PL, Kirchhausen T. The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep. 2004 Sep; 5(9):883-8. PMID: 15332114.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  128. Boll W, Ehrlich M, Collier RJ, Kirchhausen T. Effects of dynamin inactivation on pathways of anthrax toxin uptake. Eur J Cell Biol. 2004 Jul; 83(6):281-8. PMID: 15511085.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  129. Nieland TJ, Feng Y, Brown JX, Chuang TD, Buckett PD, Wang J, Xie XS, McGraw TE, Kirchhausen T, Wessling-Resnick M. Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic. Traffic. 2004 Jul; 5(7):478-92. PMID: 15180825.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  130. Feng Y, Jadhav AP, Rodighiero C, Fujinaga Y, Kirchhausen T, Lencer WI. Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep. 2004 Jun; 5(6):596-601. PMID: 15153932.
    Citations: 44     Fields:    Translation:AnimalsCells
  131. Massol RH, Larsen JE, Fujinaga Y, Lencer WI, Kirchhausen T. Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways. Mol Biol Cell. 2004 Aug; 15(8):3631-41. PMID: 15146065.
    Citations: 35     Fields:    Translation:AnimalsCells
  132. Nieland TJ, Chroni A, Fitzgerald ML, Maliga Z, Zannis VI, Kirchhausen T, Krieger M. Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide. J Lipid Res. 2004 Jul; 45(7):1256-65. PMID: 15102890.
    Citations: 39     Fields:    Translation:HumansCells
  133. Chandran K, Parker JS, Ehrlich M, Kirchhausen T, Nibert ML. The delta region of outer-capsid protein micro 1 undergoes conformational change and release from reovirus particles during cell entry. J Virol. 2003 Dec; 77(24):13361-75. PMID: 14645591.
    Citations: 61     Fields:    Translation:AnimalsCells
  134. Larsen JE, Massol RH, Nieland TJ, Kirchhausen T. HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity. Mol Biol Cell. 2004 Jan; 15(1):323-31. PMID: 14617802.
    Citations: 18     Fields:    Translation:HumansCells