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Jean-Philippe Desilles, Ph.D., M.D.

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  1. Blanc R, Escalard S, Baharvadhat H, Desilles JP, Boisseau W, Fahed R, Redjem H, Ciccio G, Smajda S, Maier B, Delvoye F, Hebert S, Mazighi M, Piotin M. Recent advances in devices for mechanical thrombectomy. Expert Rev Med Devices. 2020 Jun 25; 1-9. PMID: 32552093.
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  2. Desilles JP, Gregoire C, Le Cossec C, Lambert J, Mophawe O, Losser MR, Lambiotte F, Le Tacon S, Cantier M, Engrand N, Trouiller P, Pottecher J. Efficacy and safety of aerosolized intra-tracheal dornase alfa administration in patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS): a structured summary of a study protocol for a randomised controlled trial. Trials. 2020 Jun 19; 21(1):548. PMID: 32560746.
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  3. Boisseau W, Escalard S, Fahed R, Lapergue B, Smajda S, Maier B, Desilles JP, Delvoye F, Ciccio G, Redjem H, Hebert S, Ben Maacha M, Walker G, Gory B, Richard S, Mazighi M, Piotin M, Blanc R. Direct aspiration stroke thrombectomy: a comprehensive review. J Neurointerv Surg. 2020 Jun 12. PMID: 32532857.
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  4. Escalard S, Maïer B, Redjem H, Delvoye F, Hébert S, Smajda S, Ciccio G, Desilles JP, Mazighi M, Blanc R, Piotin M. Treatment of Acute Ischemic Stroke due to Large Vessel Occlusion With COVID-19: Experience From Paris. Stroke. 2020 May 29; STROKEAHA120030574. PMID: 32466736.
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  5. Sabben C, Desilles JP, Charbonneau F, Savatovsky J, Morvan E, Obadia A, Raynouard I, Fela F, Escalard S, Redjem H, Smajda S, Ciccio G, Blanc R, Fahed R, Le Guerinel C, Engrand N, Ben Maacha M, Labreuche J, Mazighi M, Piotin M, Obadia M. Early successful reperfusion after endovascular therapy reduces malignant middle cerebral artery infarction occurrence in young patients with large diffusion-weighted imaging lesions. Eur J Neurol. 2020 May 20. PMID: 32431009.
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  6. Ducroux C, Desilles JP, Mawhin MA, Delbosc S, Ho-Tin-Noé B, Ollivier V, Di Meglio L, Lapergue B, Michel JB, Amarenco P. Protective Effect of ApoA1 (Apolipoprotein A1)-Milano in a Rat Model of Large Vessel Occlusion Stroke. Stroke. 2020 Jun; 51(6):1886-1890. PMID: 32404037.
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  7. Di Maria F, Kyheng M, Consoli A, Desilles JP, Gory B, Richard S, Rodesch G, Labreuche J, Girot JB, Dargazanli C, Marnat G, Lapergue B, Bourcier R. Identifying the predictors of first-pass effect and its influence on clinical outcome in the setting of endovascular thrombectomy for acute ischemic stroke: Results from a multicentric prospective registry. Int J Stroke. 2020 May 07; 1747493020923051. PMID: 32380902.
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  8. Di Meglio L, Derraz I, Solonomenjanahary M, Daly D, Chodraui Filho S, Ben Maacha M, Labreuche J, Desal H, Consoli A, Lapergue B, Blanc R, Piotin M, Mazighi M, Ho-Tin-Noé B, Desilles JP, Bourcier R. Two-layered susceptibility vessel sign is associated with biochemically quantified thrombus red blood cell content. Eur J Neurol. 2020 Jul; 27(7):1264-1271. PMID: 32243692.
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  9. Maïer B, Dargazanli C, Bourcier R, Kyheng M, Labreuche J, Mosimann PJ, Puccinelli F, Taylor G, Le Guen M, Riem R, Desilles JP, Boisseau W, Fahed R, Redjem H, Smajda S, Ciccio G, Escalard S, Blanc R, Piotin M, Lapergue B, Mazighi M. Effect of Steady and Dynamic Blood Pressure Parameters During Thrombectomy According to the Collateral Status. Stroke. 2020 Apr; 51(4):1199-1206. PMID: 32156204.
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  10. Delvoye F, Desilles JP, Mazighi M. Could we apply the criteria of DAWN and DEFUSE-3 trials for slow progressors, beyond 24 h? Acta Neurol Belg. 2020 Jan 18. PMID: 31955392.
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  11. Lefevre E, Robert T, Escalard S, Fahed R, Smajda S, Ciccio G, Desilles JP, Mazighi M, Blanc R, Piotin M. Presence of direct vertebrobasilar perforator feeders in posterior fossa arteriovenous malformations and association with poor outcomes after endovascular treatment. J Neurosurg. 2019 Nov 08; 1-9. PMID: 31703199.
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  12. Di Meglio L, Desilles JP, Ollivier V, Nomenjanahary MS, Di Meglio S, Deschildre C, Loyau S, Olivot JM, Blanc R, Piotin M, Bouton MC, Michel JB, Jandrot-Perrus M, Ho-Tin-Noé B, Mazighi M. Acute ischemic stroke thrombi have an outer shell that impairs fibrinolysis. Neurology. 2019 10 29; 93(18):e1686-e1698. PMID: 31541014.
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  13. Bourcier R, Desilles JP, Consoli A. Letter by Bourcier et al Regarding Article, "Per-Pass Analysis of Thrombus Composition in Patients With Acute Ischemic Stroke Undergoing Mechanical Thrombectomy". Stroke. 2019 10; 50(10):e295. PMID: 31514694.
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  14. Cantier M, Sabben C, Adle-Biassette H, Louedec L, Delbosc S, Desilles JP, Journé C, Diallo D, Ou P, Klein I, Chau F, Lefort A, Iung B, Duval X, Olivot JM, Ho-Tin-Noe B, Michel JB, Sonneville R, Mazighi M. Neurologic Complications of Infective Endocarditis: A Joint Model for a Septic Thromboembolism and Inflammatory Small Vessel Disease. Crit Care Med. 2019 08; 47(8):e685-e692. PMID: 31149963.
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  15. Ciccio G, Robert T, Smajda S, Fahed R, Desilles JP, Redjem H, Escalard S, Mazighi M, Blanc R, Piotin M. Double stent assisted coiling of intracranial bifurcation aneurysms in Y and X configurations with the Neuroform ATLAS stent: immediate and mid term angiographic and clinical follow-up. J Neurointerv Surg. 2019 Dec; 11(12):1239-1242. PMID: 31352373.
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  16. Boisseau W, Fahed R, Lapergue B, Desilles JP, Zuber K, Khoury N, Garcia J, Maïer B, Redjem H, Ciccio G, Smajda S, Escalard S, Taylor G, Mazighi M, Michel P, Gory B, Blanc R. Predictors of Parenchymal Hematoma After Mechanical Thrombectomy: A Multicenter Study Stroke. 2019 09; 50(9):2364-2370. PMID: 31670928.
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  17. Boisseau W, Desilles JP, Fahed R, Kyheng M, Zuber K, Sabben C, Taylor G, Ben Maacha M, Maier B, Botta D, Escalard S, Ciccio G, Smajda S, Redjem H, Piotin M, Mazighi M, Blanc R. Neutrophil count predicts poor outcome despite recanalization after endovascular therapy. Neurology. 2019 07 30; 93(5):e467-e475. PMID: 31239356.
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  18. Weisenburger-Lile D, Blanc R, Kyheng M, Desilles JP, Labreuche J, Piotin M, Mazighi M, Consoli A, Lapergue B, Gory B. Direct Admission versus Secondary Transfer for Acute Stroke Patients Treated with Intravenous Thrombolysis and Thrombectomy: Insights from the Endovascular Treatment in Ischemic Stroke Registry. Cerebrovasc Dis. 2019; 47(3-4):112-120. PMID: 31063998.
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  19. Sgreccia A, Duchmann Z, Desilles JP, Lapergue B, Labreuche J, Kyheng M, Bourcier R, Consoli A. Association between acute ischemic stroke etiology and macroscopic aspect of retrieved clots: is a clot's color a warning light for underlying pathologies? J Neurointerv Surg. 2019 Dec; 11(12):1197-1200. PMID: 31053576.
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  20. Panni P, Gory B, Xie Y, Consoli A, Desilles JP, Mazighi M, Labreuche J, Piotin M, Turjman F, Eker OF, Bracard S, Anxionnat R, Richard S, Hossu G, Blanc R, Lapergue B. Acute Stroke With Large Ischemic Core Treated by Thrombectomy. Stroke. 2019 05; 50(5):1164-1171. PMID: 31009354.
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  21. Desilles JP, Mazighi M, Ho-Tin-Noé B. Letter by Desilles et al Regarding Article, "Ischemia-Reperfusion Injury After Endovascular Thrombectomy for Ischemic Stroke". Stroke. 2019 03; 50(3):e98. PMID: 30727828.
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  22. Baharvahdat H, Blanc R, Fahed R, Smajda S, Ciccio G, Desilles JP, Redjem H, Escalard S, Mazighi M, Chauvet D, Robert T, Sasannejad P, Piotin M. Endovascular Treatment for Low-Grade (Spetzler-Martin I-II) Brain Arteriovenous Malformations. AJNR Am J Neuroradiol. 2019 04; 40(4):668-672. PMID: 30792251.
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  23. Khoury N, Dargazanli C, Guenego A, Zuber K, Ekmen A, Charbonnier G, Hebert S, Capron J, Sabben C, Morvan E, Boisseau W, Maier B, Premat K, Clarençon F, Smajda S, Redjem H, Chalumeau V, Boulouis G, Chetrit A, Lecler A, Koskas P, Duron L, Ciccio G, Ducroux C, Escalard S, Desilles JP, Hamdani M, Lapergue B, Mazighi M, Ben Maacha M, Brikci-Nigassa N, Blanc R, Piotin M, Fahed R. Visual assessment of diffusion weighted imaging infarct volume lacks accuracy and reliability. J Neurointerv Surg. 2019 Sep; 11(9):947-954. PMID: 30712012.
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  24. Guenego A, Khoury N, Blanc R, Mazighi M, Smajda S, Redjem H, Ciccio G, Desilles JP, Escalard S, Zuber K, Chamard P, Hamdani M, Brikci-Nigassa N, Ben Maacha M, Piotin M, Fahed R. Gadolinium-Enhanced Extracranial MRA Prior to Mechanical Thrombectomy Is Not Associated With an Improved Procedure Speed. Front Neurol. 2018; 9:1171. PMID: 30687224.
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  25. Godier A, Dupont M, Desilles JP, Le Guerinel C, Taylor G, Perrin M, Martin AC, Gaussem P. Successful Use of Recombinant Activated Factor VII to Reverse Ticagrelor-Induced Bleeding Risk: A Case Report. TH Open. 2018 Jul; 2(3):e346-e349. PMID: 31249959.
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  26. Maïer B, Turc G, Taylor G, Blanc R, Obadia M, Smajda S, Desilles JP, Redjem H, Ciccio G, Boisseau W, Sabben C, Ben Machaa M, Hamdani M, Leguen M, Gayat E, Blacher J, Lapergue B, Piotin M, Mazighi M. Prognostic Significance of Pulse Pressure Variability During Mechanical Thrombectomy in Acute Ischemic Stroke Patients. J Am Heart Assoc. 2018 09 18; 7(18):e009378. PMID: 30371208.
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  27. Di Meglio L, Desilles JP, Mazighi M, Ho-Tin-Noé B. Thrombolysis-resistant intracranial clot. Neurology. 2018 06 05; 90(23):1075. PMID: 29866933.
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  28. Ducroux C, Desilles JP, Ho-Tin-Noe B. Response by Ducroux et al to Letter Regarding Article, "Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke". Stroke. 2018 07; 49(7):e266. PMID: 29866748.
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  29. Ducroux C, Khoury N, Lecler A, Blanc R, Chetrit A, Redjem H, Ciccio G, Smajda S, Escalard S, Desilles JP, Mazighi M, Ben Maacha M, Piotin M, Fahed R. Application of the DAWN clinical imaging mismatch and DEFUSE 3 selection criteria: benefit seems similar but restrictive volume cut-offs might omit potential responders. Eur J Neurol. 2018 08; 25(8):1093-1099. PMID: 29667266.
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  30. Chalumeau V, Blanc R, Redjem H, Ciccio G, Smajda S, Desilles JP, Botta D, Escalard S, Boisseau W, Maïer B, Labreuche J, Obadia M, Piotin M, Mazighi M. Anterior cerebral artery embolism during thrombectomy increases disability and mortality. J Neurointerv Surg. 2018 Nov; 10(11):1057-1062. PMID: 29739828.
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  31. Escalard S, Gory B, Kyheng M, Desilles JP, Redjem H, Ciccio G, Smajda S, Labreuche J, Mazighi M, Piotin M, Blanc R, Lapergue B, Fahed R. Unknown-onset strokes with anterior circulation occlusion treated by thrombectomy after DWI-FLAIR mismatch selection. Eur J Neurol. 2018 05; 25(5):732-738. PMID: 29356273.
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  32. Desilles JP, Syvannarath V, Di Meglio L, Ducroux C, Boisseau W, Louedec L, Jandrot-Perrus M, Michel JB, Mazighi M, Ho-Tin-Noé B. Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion. J Am Heart Assoc. 2018 03 01; 7(5). PMID: 29496683.
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  33. Ducroux C, Di Meglio L, Loyau S, Delbosc S, Boisseau W, Deschildre C, Ben Maacha M, Blanc R, Redjem H, Ciccio G, Smajda S, Fahed R, Michel JB, Piotin M, Salomon L, Mazighi M, Ho-Tin-Noe B, Desilles JP. Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke. Stroke. 2018 03; 49(3):754-757. PMID: 29438080.
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  34. Fahed R, Lecler A, Sabben C, Khoury N, Ducroux C, Chalumeau V, Botta D, Kalsoum E, Boisseau W, Duron L, Cabral D, Koskas P, Benaïssa A, Koulakian H, Obadia M, Maïer B, Weisenburger-Lile D, Lapergue B, Wang A, Redjem H, Ciccio G, Smajda S, Desilles JP, Mazighi M, Ben Maacha M, Akkari I, Zuber K, Blanc R, Raymond J, Piotin M. DWI-ASPECTS (Diffusion-Weighted Imaging-Alberta Stroke Program Early Computed Tomography Scores) and DWI-FLAIR (Diffusion-Weighted Imaging-Fluid Attenuated Inversion Recovery) Mismatch in Thrombectomy Candidates: An Intrarater and Interrater Agreement Study. Stroke. 2018 01; 49(1):223-227. PMID: 29191851.
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  35. Dargazanli C, Arquizan C, Gory B, Consoli A, Labreuche J, Redjem H, Eker O, Decroix JP, Corlobé A, Mourand I, Gaillard N, Ayrignac X, Charif M, Duhamel A, Labeyrie PE, Riquelme C, Ciccio G, Smajda S, Desilles JP, Gascou G, Lefèvre PH, Mantilla-García D, Cagnazzo F, Coskun O, Mazighi M, Riva R, Bourdain F, Labauge P, Rodesch G, Obadia M, Bonafé A, Turjman F, Costalat V, Piotin M, Blanc R, Lapergue B. Mechanical Thrombectomy for Minor and Mild Stroke Patients Harboring Large Vessel Occlusion in the Anterior Circulation: A Multicenter Cohort Study. Stroke. 2017 12; 48(12):3274-3281. PMID: 29089458.
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  36. Blanc R, Fahed R, Roux P, Smajda S, Ciccio G, Desilles JP, Redjem H, Mazighi M, Baharvahdat H, Piotin M. Augmented 3D venous navigation for neuroendovascular procedures. J Neurointerv Surg. 2018 Jul; 10(7):649-652. PMID: 29021314.
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  37. Maïer B, Gory B, Taylor G, Labreuche J, Blanc R, Obadia M, Abrivard M, Smajda S, Desilles JP, Redjem H, Ciccio G, Lukaszewicz AC, Turjman F, Riva R, Labeyrie PE, Duhamel A, Blacher J, Piotin M, Lapergue B, Mazighi M. Mortality and Disability According to Baseline Blood Pressure in Acute Ischemic Stroke Patients Treated by Thrombectomy: A Collaborative Pooled Analysis. J Am Heart Assoc. 2017 10 10; 6(10). PMID: 29018023.
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  38. Cantier M, Mazighi M, Klein I, Desilles JP, Wolff M, Timsit JF, Sonneville R. Neurologic Complications of Infective Endocarditis: Recent Findings. Curr Infect Dis Rep. 2017 Sep 19; 19(11):41. PMID: 28929294.
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  39. Desilles JP, Syvannarath V, Ollivier V, Journé C, Delbosc S, Ducroux C, Boisseau W, Louedec L, Di Meglio L, Loyau S, Jandrot-Perrus M, Potier L, Michel JB, Mazighi M, Ho-Tin-Noé B. Exacerbation of Thromboinflammation by Hyperglycemia Precipitates Cerebral Infarct Growth and Hemorrhagic Transformation. Stroke. 2017 07; 48(7):1932-1940. PMID: 28526762.
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  40. Blanc R, Redjem H, Ciccio G, Smajda S, Desilles JP, Orng E, Taylor G, Drumez E, Fahed R, Labreuche J, Mazighi M, Lapergue B, Piotin M. Predictors of the Aspiration Component Success of a Direct Aspiration First Pass Technique (ADAPT) for the Endovascular Treatment of Stroke Reperfusion Strategy in Anterior Circulation Acute Stroke. Stroke. 2017 06; 48(6):1588-1593. PMID: 28428348.
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  41. Dargazanli C, Consoli A, Gory B, Blanc R, Labreuche J, Preda C, Bourdain F, Decroix JP, Redjem H, Ciccio G, Mazighi M, Smajda S, Desilles JP, Riva R, Labeyrie PE, Coskun O, Rodesch G, Turjman F, Piotin M, Lapergue B. Is Reperfusion Useful in Ischaemic Stroke Patients Presenting with a Low National Institutes of Health Stroke Scale and a Proximal Large Vessel Occlusion of the Anterior Circulation? Cerebrovasc Dis. 2017; 43(5-6):305-312. PMID: 28384632.
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  42. Desilles JP, Consoli A, Redjem H, Coskun O, Ciccio G, Smajda S, Labreuche J, Preda C, Ruiz Guerrero C, Decroix JP, Rodesch G, Mazighi M, Blanc R, Piotin M, Lapergue B. Successful Reperfusion With Mechanical Thrombectomy Is Associated With Reduced Disability and Mortality in Patients With Pretreatment Diffusion-Weighted Imaging-Alberta Stroke Program Early Computed Tomography Score =6. Stroke. 2017 04; 48(4):963-969. PMID: 28235960.
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  43. Dargazanli C, Consoli A, Barral M, Labreuche J, Redjem H, Ciccio G, Smajda S, Desilles JP, Taylor G, Preda C, Coskun O, Rodesch G, Piotin M, Blanc R, Lapergue B. Impact of Modified TICI 3 versus Modified TICI 2b Reperfusion Score to Predict Good Outcome following Endovascular Therapy. AJNR Am J Neuroradiol. 2017 Jan; 38(1):90-96. PMID: 27811134.
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  44. Desilles JP, Loyau S, Syvannarath V, Gonzalez-Valcarcel J, Cantier M, Louedec L, Lapergue B, Amarenco P, Ajzenberg N, Jandrot-Perrus M, Michel JB, Ho-Tin-Noe B, Mazighi M. Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke. Stroke. 2015 Nov; 46(11):3241-8. PMID: 26443832.
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  45. Labeyrie MA, Lenck S, Bresson D, Desilles JP, Bisdorff A, Saint-Maurice JP, Houdart E. Parent artery occlusion in large, giant, or fusiform aneurysms of the carotid siphon: clinical and imaging results. AJNR Am J Neuroradiol. 2015 Jan; 36(1):140-5. PMID: 25082818.
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  46. Hyafil F, Klein I, Desilles JP, Mazighi M, Le Guludec D, Amarenco P. Rupture of nonstenotic carotid plaque as a cause of ischemic stroke evidenced by multimodality imaging. Circulation. 2014 Jan 07; 129(1):130-1. PMID: 24396017.
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  47. Olivot JM, Mosimann PJ, Labreuche J, Inoue M, Meseguer E, Desilles JP, Rouchaud A, Klein IF, Straka M, Bammer R, Mlynash M, Amarenco P, Albers GW, Mazighi M. Impact of diffusion-weighted imaging lesion volume on the success of endovascular reperfusion therapy. Stroke. 2013 Aug; 44(8):2205-11. PMID: 23760215.
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  48. Desilles JP, Meseguer E, Labreuche J, Lapergue B, Sirimarco G, Gonzalez-Valcarcel J, Lavallée P, Cabrejo L, Guidoux C, Klein I, Amarenco P, Mazighi M. Diabetes mellitus, admission glucose, and outcomes after stroke thrombolysis: a registry and systematic review. Stroke. 2013 Jul; 44(7):1915-23. PMID: 23704108.
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  49. Lapergue B, Dang BQ, Desilles JP, Ortiz-Munoz G, Delbosc S, Loyau S, Louedec L, Couraud PO, Mazighi M, Michel JB, Meilhac O, Amarenco P. High-density lipoprotein-based therapy reduces the hemorrhagic complications associated with tissue plasminogen activator treatment in experimental stroke. Stroke. 2013 Mar; 44(3):699-707. PMID: 23422087.
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  50. Desilles JP, Rouchaud A, Labreuche J, Meseguer E, Laissy JP, Serfaty JM, Lapergue B, Klein IF, Guidoux C, Cabrejo L, Sirimarco G, Lavallée PC, Schouman-Claeys E, Amarenco P, Mazighi M. Blood-brain barrier disruption is associated with increased mortality after endovascular therapy. Neurology. 2013 Feb 26; 80(9):844-51. PMID: 23365060.
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  51. Meseguer E, Mazighi M, Lapergue B, Labreuche J, Sirimarco G, Gonzalez-Valcarcel J, Lavallée PC, Cabrejo L, Guidoux C, Klein IF, Olivot JM, Rouchaud A, Desilles JP, Amarenco P. Outcomes after thrombolysis in AIS according to prior statin use: a registry and review. Neurology. 2012 Oct 23; 79(17):1817-23. PMID: 23091074.
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  52. Mazighi M, Meseguer E, Labreuche J, Serfaty JM, Laissy JP, Lavallée PC, Cabrejo L, Guidoux C, Lapergue B, Klein IF, Olivot JM, Rouchaud A, Desilles JP, Schouman-Claeys E, Amarenco P. Dramatic recovery in acute ischemic stroke is associated with arterial recanalization grade and speed. Stroke. 2012 Nov; 43(11):2998-3002. PMID: 22935403.
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  53. Gobert F, Cho TH, Desilles JP, Hermier M, Mechtouff L, Derex L, Nighoghossian N. Magnetic resonance imaging-based intravenous thrombolysis 6 hours after onset of minor cerebellar stroke. Arch Neurol. 2011 May; 68(5):678. PMID: 21555649.
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  54. Desilles JP, Cho TH, Hermier M, Mechtouff-Cimarelli L, Derex L, Nighoghossian N. Magnetic resonance imaging-guided thrombolysis in minor stroke. Int J Stroke. 2011 Apr; 6(2):178. PMID: 21371285.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.